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https://www.readbyqxmd.com/read/28728256/-single-center-retrospective-study-of-184-children-with-inflammatory-bowel-disease-seen-from-2000-2014
#1
D X Guan, F H Yu, G L Wang, J Zhou, D Y Wang, X L Nie, X W Xu
Objective: To investigate the clinical data of children with inflammatory bowel disease (IBD) retrospectively, including Crohn's disease (CD) and ulcerative colitis (UC) and identify the clinical characteristics and trends of change. Method: Clinical data of hospitalized patients diagnosed as IBD in Beijing Children's Hospital from January 2000 to December 2014 were collected and retrospectively analyzed. Patients were divided into six groups based on type of disease and year of admission: Group A1(CD, 2000-2004) included 12 patients, Group B1(CD, 2005-2009) included 11, Group C1(CD, 2010-2014) included 51; Group A2(UC, 2000-2004) included 17, Group B2(UC, 2005-2009) included 25, Group C2(UC, 2010-2014) included 68...
July 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28727664/effect-of-self-efficacy-intervention-on-quality-of-life-of-patients-with-intestinal-stoma
#2
Shujuan Xu, Zhiyun Zhang, Aimei Wang, Jiangyun Zhu, Hongzhi Tang, Xiaoli Zhu
Colorectal carcinoma is one of the most common malignancies worldwide and the most prevalent cause of cancer mortality in China. The Miles operation and permanent colostomy are effective treatment. However, these affect the quality of life of patients as they alter normal defecation. Self-efficacy is used to define an individuals' assessments of their ability to perform a specific behavior successfully. It is regarded as an important belief that can predict health behaviors. The aim of this study was to explore the effect of a self-efficacy intervention on the quality of life of patients with a permanent colostomy...
July 19, 2017: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/28723961/dysfunctional-gpr40-ffar1-signaling-exacerbates-pain-behavior-in-mice
#3
Kazuo Nakamoto, Fuka Aizawa, Kei Miyagi, Takuya Yamashita, Mitsumasa Mankura, Yutaka Koyama, Fumiyo Kasuya, Akira Hirasawa, Takashi Kurihara, Atsuro Miyata, Shogo Tokuyama
We previously showed that activation of G protein-coupled receptor 40/free fatty acid receptor 1 (GPR40/FFAR1) signaling modulates descending inhibition of pain. In this study, we investigated the involvement of fatty acid-GPR40/FFAR1 signaling in the transition from acute to chronic pain. We used GPR40/FFAR1-knockout (GPR40KO) mice and wild-type (WT) mice. A plantar incision was performed, and mechanical allodynia and thermal hyperalgesia were evaluated with a von Frey filament test and plantar test, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28716269/dopamine-agonist-withdrawal-syndrome-daws-in-a-tertiary-parkinson-disease-treatment-center
#4
Shnehal Patel, Xiomara Garcia, Mohammad Edrees Mohammad, Xin Xin Yu, Katelyn Vlastaris, Kaley O'Donnell, Kathryn Sutton, Hubert H Fernandez
INTRODUCTION: Dopamine agonists are a mainstay of treatment for patients with Parkinson disease (PD). However, side effects limit their use, often necessitating dose change. Upon withdrawal, patients may experience dopamine agonist withdrawal syndrome (DAWS). To date, there is no established protocol for the prevention or treatment of DAWS. METHODS: We performed a retrospective chart review of PD patients who were taking a dopamine agonist. RESULTS: In our large cohort of 313 PD patients who were on a dopamine agonist, we found that 39...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28713483/the-treadmill-exercise-protects-against-dopaminergic-neuron-loss-and-brain-oxidative-stress-in-parkinsonian-rats
#5
Roberta Oliveira da Costa, Carlos Vinicius Jataí Gadelha-Filho, Ayane Edwiges Moura da Costa, Mariana Lima Feitosa, Dayane Pessoa de Araújo, Jalles Dantas de Lucena, Pedro Everson Alexandre de Aquino, Francisco Arnaldo Viana Lima, Kelly Rose Tavares Neves, Glauce Socorro de Barros Viana
Parkinson's disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments. The objectives were to support data on exercise benefits to PD. Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise. The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6-OHDA injection. Those from no-exercise groups stayed on the treadmill for the same period and, afterwards, were subjected to behavioral tests and euthanized for neurochemical and immunohistochemical assays...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28708753/effectiveness-of-preoperative-intranasal-dexmedetomidine-compared-with-oral-midazolam-for-the-prevention-of-emergence-delirium-in-the-pediatric-patient-undergoing-general-anesthesia-a-systematic-review
#6
James FitzSimons, Laura S Bonanno, Stephanie Pierce, Jennifer Badeaux
BACKGROUND: Emergence delirium is defined as a cognitive disturbance during emergence from general anesthesia resulting in hallucinations, delusions and confusion manifested by agitation, restlessness, involuntary physical movement and extreme flailing in bed. Postoperative emergence delirium develops in 12% to 18% of all children undergoing general anesthesia for surgery. This post-anesthetic phenomenon changes cognitive and psychomotor behavior, and puts pediatric patients and health care personnel at risk of injury...
July 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28689321/underestimated-risk-of-cancer-in-solitary-thyroid-nodules-%C3%A2-3%C3%A2-cm-reported-as-benign
#7
Sohail Bakkar, Anello Marcello Poma, Caterina Corsini, Mario Miccoli, Carlo Enrico Ambrosini, Paolo Miccoli
BACKGROUND: The study aims to assess the risk of cancer in solitary thyroid nodules ≥30 mm in size reported as Bethesda II, and its implications. METHOD: The clinical records of 202 patients, who underwent thyroid lobectomy for solitary nodules measuring ≥30 mm, reported as Bethesda II on preoperative FNAC between Jan 2015 and Apr 2016 were reviewed. Data collected included nodule size and consistency, and final histopathology results. The risk of cancer and the recommended management according to ATA guidelines were the outcomes of interest...
July 8, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28685530/early-and-late-behavioral-changes-in-sciatic-nerve-injury-may-be-modulated-by-nerve-growth-factor-and-substance-p-in-rats-a-chronic-constriction-injury-long-term-evaluation
#8
J T Da Silva, B G Evangelista, R A G Venega, M E Oliveira, M Chacur
Chronic constriction injury (CCI) simulates the symptoms of chronic nerve compression, which is characterized by allodynia and hyperalgesia. Nerve growth factor (NGF) is released after nerve injury by immune and Schwann cells and transported in retrograde fashion to the dorsal root ganglion (DRG), resulting in increased synthesis of Substance P (SP) and the triggering of neuropathic pain. Here we performed long-term evaluation of allodynia and hyperalgesia in a CCI model, and evaluated the effects of NGF and SP on the peripheral and central nervous systems...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28685361/bariatric-surgery-promising-in-migraine-control-a-controlled-trial-on-weight-loss-and-its-effect-on-migraine-headache
#9
Soodeh Razeghi Jahromi, Maryam Abolhasani, Zeinab Ghorbani, Solmaz Sadre-Jahani, Zahra Alizadeh, Mohammad Talebpour, Alipasha Meysamie, Mansoureh Togha
INTRODUCTION: There is evidence that substantial weight loss through bariatric surgery (BS) may result in short-term improvement of migraine severity. However, it still remains to be seen whether smaller amounts of weight loss have a similar effect on migraine headache. This study has been designed to compare the effects of weight reduction through BS and non-surgical modifications. MATERIALS AND METHODS: Migraine characteristics were assessed at 1 month before (T0), 1 month (T1), and 6 months (T2) after BS (vertical sleeve gastrectomy (VSG) (n = 25) or behavioral therapy (BT) (n = 26) in obese women (aged 18-60 years) with migraine headache...
July 6, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28685029/does-gastric-bypass-surgery-change-body-weight-set-point
#10
REVIEW
Z Hao, M B Mumphrey, C D Morrison, H Münzberg, J Ye, H R Berthoud
The relatively stable body weight during adulthood is attributed to a homeostatic regulatory mechanism residing in the brain which uses feedback from the body to control energy intake and expenditure. This mechanism guarantees that if perturbed up or down by design, body weight will return to pre-perturbation levels, defined as the defended level or set point. The fact that weight re-gain is common after dieting suggests that obese subjects defend a higher level of body weight. Thus, the set point for body weight is flexible and likely determined by the complex interaction of genetic, epigenetic and environmental factors...
December 2016: International Journal of Obesity Supplements
https://www.readbyqxmd.com/read/28684640/early-sepsis-does-not-stimulate-reactive-oxygen-species-production-and-does-not-reduce-cardiac-function-despite-an-increased-inflammation-status
#11
Thibault Léger, Alice Charrier, Clarisse Moreau, Isabelle Hininger-Favier, Evangelia Mourmoura, Jean-Paul Rigaudière, Elodie Pitois, Damien Bouvier, Vincent Sapin, Bruno Pereira, Kasra Azarnoush, Luc Demaison
If it is sustained for several days, sepsis can trigger severe abnormalities of cardiac function which leads to death in 50% of cases. This probably occurs through activation of toll-like receptor-9 by bacterial lipopolysaccharides and overproduction of proinflammatory cytokines such as TNF-α and IL-1β In contrast, early sepsis is characterized by the development of tachycardia. This study aimed at determining the early changes in the cardiac function during sepsis and at finding the mechanism responsible for the observed changes...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28684004/tavr-vs-savr-rising-expectations-and-changing-indications-for-surgery-in-response-to-partner-ii
#12
Cristiano Spadaccio, Francesco Nappi, Jean-Louis Sablayrolles, Fraser W H Sutherland
Despite the criticisms and concerns raised on the data published in the PARTNER II trial and related analyses, we are undeniably witnessing a revolution in the management of aortic valve disease, in which conventional full sternotomy surgical aortic valve replacement (SAVR), with all related complications and clinical burden, will soon become a nonviable option. Several of the findings described in the PARTNER II trial, although considerable as points of incongruence and study biases in comparison with SAVR, could be taken as lessons to found a new course in SAVR and redesign the respective roles of surgery and interventional procedures in aortic disease...
April 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28683064/murine-chronic-lymph-node-window-for-longitudinal-intravital-lymph-node-imaging
#13
Eelco F J Meijer, Han-Sin Jeong, Ethel R Pereira, Thomas A Ruggieri, Cedric Blatter, Benjamin J Vakoc, Timothy P Padera
Chronic imaging windows in mice have been developed to allow intravital microscopy of many different organs and have proven to be of paramount importance in advancing our knowledge of normal and disease processes. A model system that allows long-term intravital imaging of lymph nodes would facilitate the study of cell behavior in lymph nodes during the generation of immune responses in a variety of disease settings and during the formation of metastatic lesions in cancer-bearing mice. We describe a chronic lymph node window (CLNW) surgical preparation that allows intravital imaging of the inguinal lymph node in mice...
August 2017: Nature Protocols
https://www.readbyqxmd.com/read/28678112/prosthesis-and-hybrid-strategy-consideration-for-treating-2-level-cervical-disc-degeneration-in-hybrid-surgery
#14
Yang Li, Guy R Fogel, Zhenhua Liao, Rajnesh Tyagi, Weiqiang Liu
STUDY DESIGN: Biomechanical analysis using a validated nonlinear finite element (FE) model. OBJECTIVE: To combine the strategy of two-level hybrid surgery (HS) to explore how prostheses affect cervical biomechanics. SUMMARY OF BACKGROUND DATA: Few FE studies have explored differences in biomechanical behavior between combined and stand-alone structured prostheses with HS. No FE studies have considered whether the prosthesis type and hybrid strategy influence two-level HS...
July 3, 2017: Spine
https://www.readbyqxmd.com/read/28663075/a-comparison-of-perceived-and-calculated-weight-status-classification-congruence-between-pre-and-post-bariatric-surgery-patients
#15
Megan Ferriby, Keeley Pratt, Sabrena Noria, Bradley Needleman
BACKGROUND: One prominent reason patients undergo bariatric surgery is to reduce their excess weight and body mass index. Weight status classifications (WSCs), based on calculated body mass index, organize patients into distinct groups (underweight, healthy weight, overweight, class I obesity, class II obesity, and class III obesity) for treatment recommendations, including surgery for patients with obesity. Bariatric patients' perceptions of their WSC is important to consider, because patients who accurately perceive their WSC presurgery have greater motivation for health behavior changes; alternatively, incongruence between perceived and calculated WSC could deter motivation and ultimately their health changes postsurgery...
May 15, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28651707/behavioral-regression-in-2-patients-with-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder-after-oral-surgery-performed-with-a-general-anesthetic
#16
Seth Matton, Gerardo P Romeo
BACKGROUND AND OVERVIEW: Routine dental care for people with autism spectrum disorders can be complex. There is little published on postoperative behavioral changes associated with use of general anesthetics in this population. CASE DESCRIPTION: The authors describe postoperative behavioral changes in 2 patients with autism spectrum disorder and attention deficit hyperactivity disorder that the patients' caretakers described as regression. In both cases, behaviors representative of autism spectrum disorder and attention deficit hyperactivity disorder worsened after uncomplicated oral surgery after receipt of a general anesthetic in the operating room...
July 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28643887/personality-dopamine-and-parkinson-s-disease-insights-from-subthalamic-stimulation
#17
Eugénie Lhommée, François Boyer, Maxime Wack, Pierre Pélissier, Hélène Klinger, Emmanuelle Schmitt, Amélie Bichon, Valérie Fraix, Stéphan Chabardès, Patrick Mertens, Anna Castrioto, Andrea Kistner, Emmanuel Broussolle, Stéphane Thobois, Paul Krack
BACKGROUND: Subthalamic stimulation improves the motor and neuropsychiatric symptoms of Parkinson's disease. However, the impact of this treatment on impulse control and personality is the subject of heavy debate. The objective of this study was to investigate personality changes after subthalamic stimulation. METHODS: Using Cloninger's biosocial model, we assessed personality in 73 Parkinson's disease patients before and 12 months after subthalamic stimulation accompanied by a drastic reduction in dopaminergic medication...
June 23, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28638356/how-can-smoking-cessation-be-induced-before-surgery-a-systematic-review-and-meta-analysis-of-behavior-change-techniques-and-other-intervention-characteristics
#18
REVIEW
Andrew Prestwich, Sally Moore, Alwyn Kotze, Luke Budworth, Rebecca Lawton, Ian Kellar
Background: Smokers who continue to smoke up to the point of surgery are at increased risk of a range of complications during and following surgery. Objective: To identify whether behavioral and/or pharmacological interventions increase the likelihood that smokers quit prior to elective surgery and which intervention components are associated with larger effects. Design: Systematic review with meta-analysis. Data sources: MEDLINE, Embase, and Embase Classic, CINAHL, CENTRAL. Study selection: Studies testing the effect of smoking reduction interventions delivered at least 24 h before elective surgery were included...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28625002/changes-in-dietary-intake-and-eating-behavior-in-adolescents-after-bariatric-surgery-an-ancillary-study-to-the-teen-labs-consortium
#19
David B Sarwer, Rebecca J Dilks, Jacqueline C Spitzer, Robert I Berkowitz, Thomas A Wadden, Renee H Moore, Jesse L Chittams, Mary L Brandt, Mike K Chen, Anita P Courcoulas, Carroll M Harmon, Michael A Helmrath, Marc P Michalsky, Stavra A Xanthakos, Meg H Zeller, Todd M Jenkins, Thomas H Inge
BACKGROUND: A growing number of studies suggest that bariatric surgery is safe and effective for adolescents with severe obesity. However, surprisingly little is known about changes in dietary intake and eating behavior of adolescents who undergo bariatric surgery. OBJECTIVE: Investigate changes in dietary intake and eating behavior of adolescents with obesity who underwent bariatric surgery (n = 119) or lifestyle modification (LM) (n = 169). SETTING: University-based health systems METHODS: A prospective investigation of 288 participants (219 female and 69 male) prior to bariatric surgery or LM and again 6, 12, and 24 months (surgery patients only) after treatment...
June 17, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28618128/sexual-life-after-mastectomy-in-breast-cancer-survivors-a-qualitative-study
#20
Nasrin Fouladi, Farhad Pourfarzi, Negin Dolattorkpour, Sara Alimohammadi, Elham Mehrara
BACKGROUND: Mastectomy is a highly frequent form of breast cancer treatment in Iran, and exual dysfunction after mastectomy has been reported in the majority of breast cancer survivors in Iran. In this qualitative study, an attempt was made to examine the stages that patients go through in their sexual lives after mastectomy. METHOD AND MATERIALS: Using purposeful sampling, 30 married women, who had undergone surgery and had completed an adjuvant treatment period, participated in the study...
June 15, 2017: Psycho-oncology
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