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https://www.readbyqxmd.com/read/29786131/ca19-9-on-postoperative-surveillance-in-pancreatic-ductal-adenocarcinoma-predicting-recurrence-and-changing-prognosis-over-time
#1
Caroline J Rieser, Mazen Zenati, Ahmad Hamad, Amr I Al Abbas, Nathan Bahary, Amer H Zureikat, Herbert J Zeh, Melissa E Hogg
BACKGROUND: Serum carbohydrate antigen 19-9 (CA19-9) correlates with response to therapy and overall survival (OS) for patients with pancreatic ductal adenocarcinoma (PDAC). This study aimed to define the chronologic relationship between CA19-9 elevation and radiographic recurrence to develop a model that can predict the risk of recurrence (RFS) and prognosis during interval surveillance for patients with resected PDAC. METHODS: A retrospective review examined patients undergoing surgery for pancreatic adenocarcinoma from January 2010 to May 2016...
May 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29778746/betulinic-acid-a-natural-pde-inhibitor-restores-hippocampal-camp-cgmp-and-bdnf-improve-cerebral-blood-flow-and-recover-memory-deficits-in-permanent-bccao-induced-vascular-dementia-in-rats
#2
Madhu Kaundal, Saima Zameer, Abul Kalam Najmi, Suhel Parvez, Mohd Akhtar
Vascular dementia (VaD) is the second most common form of senile dementia, embraces memory deficits, neuroinflammation, executive function damage, mood and behavioral changes and abnormal cerebral blood flow. The purpose of the study was to explore the therapeutic potential of betulinic acid in bilateral common carotid artery occlusion (BCCAO) induced VaDin experimental rats.VaD was induced by BCCAO in rats and betulinic acid (10 and 15mg/kg/day po) was administered 1 week after surgery. The cerebral blood pressure of the animal was recorded before and after the treatment using Laser Doppler flow meter...
May 17, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29777950/acceptance-and-commitment-therapy-for-prevention-of-chronic-post-surgical-pain-and-opioid-use-in-at-risk-veterans-a-pilot-randomized-controlled-study
#3
Lilian Dindo, M Bridget Zimmerman, Katherine Hadlandsmyth, Barbara StMarie, Jennie Embree, James Marchman, Toni Tripp-Reimer, Barbara Rakel
High levels of pain, significant anxiety, and/or depressive symptoms prior to surgery put patients at elevated risk forchronic pain and prolonged opioid use following surgery. The purpose of this preliminary study was to assess the efficacy of a one-day Acceptance and Commitment Therapy (ACT) workshop in "at-risk" Veterans for the prevention of chronic pain and opioid use following orthopedic surgery. In a randomized controlled trial, 88 at-risk Veterans undergoing orthopedic surgery were assigned to Treatment as Usual (TAU; N =44) or TAU plus a 1-day ACT workshop (N = 44)...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29775977/-rehabilitation-after-traumatic-fracture-of-thoracic-and-lumbar-spine
#4
Hartmut Bork, Stefan Simmel, Eckhardt Böhle, Ulrich Ernst, Klaus Fischer, Bernd Fromm, Jean-Jacques Glaesener, Bernhard Greitemann, P Krause, S Panning, V Pullwitt, J Schmidt, Andreas Veihelmann, Lutz Vogt
On the basis of the S2-k guideline "Rehabilitation after traumatic fractures of the thoracic und lumbar spine without neurologic disorder", this article gives an overview of target-oriented rehabilitation of patients with minor fractures or those with column stability and unstable spinal fractures which are stabilised by surgery. To obtain early social and job related reintegration, outpatient or inpatient rehabilitation has to start immediately after treatment in hospital. Rehabilitation must be orientated towards the biopsychosocial model of ICF and has to be adapted for the patient...
May 18, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29773324/comparison-of-pitch-strength-with-perceptual-and-other-acoustic-metric-outcome-measures-following-medialization-laryngoplasty
#5
Adam D Rubin, Cristina Jackson-Menaldi, Lisa M Kopf, Katherine Marks, Jean Skeffington, Mark D Skowronski, Rahul Shrivastav, Eric J Hunter
INTRODUCTION: The diagnoses of voice disorders, as well as treatment outcomes, are often tracked using visual (eg, stroboscopic images), auditory (eg, perceptual ratings), objective (eg, from acoustic or aerodynamic signals), and patient report (eg, Voice Handicap Index and Voice-Related Quality of Life) measures. However, many of these measures are known to have low to moderate sensitivity and specificity for detecting changes in vocal characteristics, including vocal quality. OBJECTIVE: The objective of this study was to compare changes in estimated pitch strength (PS) with other conventionally used acoustic measures based on the cepstral peak prominence (smoothed cepstral peak prominence, cepstral spectral index of dysphonia, and acoustic voice quality index), and clinical judgments of voice quality (GRBAS [grade, roughness, breathiness, asthenia, strain] scale) following laryngeal framework surgery...
May 14, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29765576/a-trend-analysis-of-surgical-operations-under-a-global-payment-system-in-tehran-iran-2005-2015
#6
Faranak Behzadi Goudari, Arash Rashidian, Mohammad Arab, Mahmood Mahmoudi, Ebrahim Jaafaripooyan
Background: Global payment system is a first example of per-case payment system that contains 60 commonly used surgical operations for which payment is based on the average cost per case in Iran. Objective: The aim of the study was to determine the amount of reduction, increase or no change in the trend of global operations. Methods: In this retrospective longitudinal study, data on the 60 primary global surgery codes was gathered from Tehran Health Insurance Organization within the ten-year period of 2005-2015 separately, for each month...
March 2018: Electronic Physician
https://www.readbyqxmd.com/read/29761422/computational-pre-surgical-planning-of-arterial-patch-reconstruction-parametric-limits-and-in-vitro-validation
#7
S Samaneh Lashkarinia, Senol Piskin, Tijen A Bozkaya, Ece Salihoglu, Can Yerebakan, Kerem Pekkan
Surgical treatment of congenital heart disease (CHD) involves complex vascular reconstructions utilizing artificial and native surgical materials. A successful surgical reconstruction achieves an optimal hemodynamic profile through the graft in spite of the complex post-operative vessel growth pattern and the altered pressure loading. This paper proposes a new in silico patient-specific pre-surgical planning framework for patch reconstruction and investigates its computational feasibility. The proposed protocol is applied to the patch repair of main pulmonary artery (MPA) stenosis in the Tetralogy of Fallot CHD template...
May 14, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29761007/behavioral-changes-induced-through-adenosine-a2a-receptor-ligands-in-a-rat-depression-model-induced-by-olfactory-bulbectomy
#8
Karla Margarita Padilla, Andres Quintanar-Setephano, Fabian López-Vallejo, Laura Cristina Berumen, Ricardo Miledi, Guadalupe García-Alcocer
Background: Major depressive disorders are characterized by their severity and long-lasting symptoms, which make such disorders highly disabling illnesses. Unfortunately, 50% of major depressive patients experience relapses, perhaps partly because drug research has been performed only in animal models that screen for antidepressant drugs that appear to only ameliorate acute depression symptoms. The bilateral olfactory bulbectomy (OBX) animal model presents the advantage of mimicking the symptoms of chronic depression by means of brain surgery...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29759259/1-300-days-and-counting-a-risk-model-approach-to-preventing-retained-foreign-objects-rfos
#9
Erika G Duggan, Jimmy Fernandez, Mary May Saulan, Dave L Mayers, Mira Nikolaj, Tamara M Strah, Lystra M Swift, Larissa Temple
BACKGROUND: A retained foreign object (RFO) is a devastating surgical complication that typically results in additional surgeries, increased length of stay, and risk of infections and is potentially fatal. Memorial Sloan Kettering Cancer Center (MSKCC) convened a multidisciplinary task force to undertake an improvement initiative to reduce the frequency of RFO incidents. METHODS: A needs assessment was undertaken using focus group interviews, review of past RFOs, and operating room (OR) observations, and a comprehensive intervention plan was initiated...
May 2018: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/29746881/binge-eating-and-other-eating-related-problems-in-adolescents-undergoing-gastric-bypass-results-from-a-swedish-nationwide-study-amos
#10
Kajsa Järvholm, Torsten Olbers, Markku Peltonen, Claude Marcus, Jovanna Dahlgren, Carl-Erik Flodmark, Pia Henfridsson, Eva Gronowitz, Jan Karlsson
Bariatric surgery is established as a treatment option for adolescents with severe obesity. Little is known about binge eating (BE) and other eating-related problems in adolescents undergoing bariatric surgery. BE, emotional eating, uncontrolled eating, and cognitive restraint were assessed at baseline, and one and two years after gastric bypass using questionnaires in 82 adolescents (mean age 16.9 years, 67% girls). BE was assessed with the Binge Eating Scale (BES) and other eating-related problems with the Three Factor Eating Questionnaire...
May 7, 2018: Appetite
https://www.readbyqxmd.com/read/29741674/evaluating-the-effects-of-general-anesthesia-on-sleep-in-children-undergoing-elective-surgery-an-observational-case-control-study
#11
S Selvadurai, J T Maynes, C McDonnell, S L Cushing, E J Propst, A Lorenzo, A Lim, L J Meltzer, Zihang Lu, R L Horner, I Narang
Study Objectives: Previous research has suggested that general anesthetics can disturb postoperative sleep patterns by affecting the sleep-wake cycle. The objective was to identify the effects of general anesthetics on sleep quality and related behavioral changes in children. Methods: This was a prospective, observational case-control study with children, aged 18 months to 8 years, undergoing general anesthesia for elective surgery. Subjects wore an actigraph for seven days on three occasions: prior to surgery, the immediate postoperative period, and three months after surgery...
May 7, 2018: Sleep
https://www.readbyqxmd.com/read/29740114/significantly-increased-low-shear-rate-viscosity-blood-elastic-modulus-and-rbc-aggregation-in-adults-following-cardiac-surgery
#12
Yi-Fan Wu, Po-Shun Hsu, Chien-Sung Tsai, Pin-Cheng Pan, Yeng-Long Chen
Open heart surgeries are common for treating ischemic and heart valve disease. During cardiac surgery, cardiopulmonary bypass (CPB) can temporarily take over the function of heart and lungs. However, elevated red blood cell (RBC) aggregation may lead to the common side-effects such as microinfarction. We investigated blood physical properties changes and the correlation between blood microstructure, viscoelastic response and biochemical changes following surgery with CPB. We examined shear-rate dependent blood viscosity, elasticity and RBC aggregate size in the pre-surgery disease state, post-surgery state and long-term recovery state of cardiac surgical patients...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29733457/age-related-changes-in-the-gut-microbiota-influence-systemic-inflammation-and-stroke-outcome
#13
Monica S Spychala, Venugopal Reddy Venna, Michal Jandzinski, Sarah J Doran, David J Durgan, Bhanu Priya Ganesh, Nadim J Ajami, Nagireddy Putluri, Joerg Graf, Robert M Bryan, Louise D McCullough
Objective Chronic systemic inflammation contributes to the pathogenesis of many age-related diseases. Although not well understood, alterations in the gut microbiota, or dysbiosis, may be responsible for age-related inflammation. Methods Using stroke as a disease model, we tested the hypothesis that a youthful microbiota, when established in aged mice, produces positive outcomes following ischemic stroke. Conversely, an aged microbiota, when established in young mice, produces negative outcomes after stroke...
May 7, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29729893/memantine-ameliorates-depressive-like-behaviors-by-regulating-hippocampal-cell-proliferation-and-neuroprotection-in-olfactory-bulbectomized-mice
#14
Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Shogo Kadota, Jinichi Isono, Takayo Odaira, Wakana Sakuma, Yuichiro Arai, Takeshi Tadano, Koichi Tan-No
Our previous study suggested that the non-competitive N-methyl-d-aspartate receptor antagonist memantine (MEM) inhibits dopamine (DA) reuptake and turnover by inhibiting brain monoamine oxidase. Clinical studies have reported that MEM may improve depressive symptoms; however, specific mechanisms underlying this effect are unclear. We performed emotional behavior, tail suspension, and forced swimming tests to examine whether MEM has antidepressant effects in olfactory bulbectomized (OBX) mice, an animal model of depression...
May 3, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29725829/involvement-of-acute-neuroinflammation-in-postoperative-delirium-like-cognitive-deficits-in-rats
#15
Takashi Kawano, Daiki Yamanaka, Bun Aoyama, Hiroki Tateiwa, Marie Shigematsu-Locatelli, Atsushi Nishigaki, Hideki Iwata, Fabricio M Locatelli, Masataka Yokoyama
PURPOSE: The purpose of this study was to investigate the age-, time-, and brain region-dependent postoperative neuroinflammatory trajectory, and its association with neurocognitive outcomes in rats. METHODS: Adult and aged rats were randomly assigned to one of three groups: control, isoflurane anesthesia alone, and isoflurane anesthesia with abdominal surgery. On either postoperative day 2 (early phase) or 7 (late phase), all rats were tested for trace and context fear memory retention after acquisition of trace fear conditioning...
May 3, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29721450/multibody-modelling-of-ligamentous-and-bony-stabilizers-in-the-human-elbow
#16
REVIEW
Mara Terzini, Elisabetta Maria Zanetti, Alberto Luigi Audenino, Giovanni Putame, Laura Gastaldi, Stefano Pastorelli, Elisa Panero, Arman Sard, Cristina Bignardi
The elbow ligamentous and bony structures play essential roles in the joint stability. Nevertheless, the contribution of different structures to joint stability is not yet clear and a comprehensive experimental investigation into the ligament and osseous constraints changes in relation to joint motions would be uphill and somehow unattainable, due to the impossibility of obtaining all the possible configurations on the same specimen. Therefore, a predictive tool of the joint behavior after the loss of retentive structures would be helpful in designing reconstructive surgeries and in pre-operative planning...
October 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/29717927/food-intake-and-eating-behavior-after-bariatric-surgery
#17
Werd Al-Najim, Neil G Docherty, Carel W le Roux
Obesity is an escalating global chronic disease. Bariatric surgery is a very efficacious treatment for obesity and its comorbidities. Alterations to gastrointestinal anatomy during bariatric surgery result in neurological and physiological changes affecting hypothalamic signaling, gut hormones, bile acids, and gut microbiota, which coalesce to exert a profound influence on eating behavior. A thorough understanding of the mechanisms underlying eating behavior is essential in the management of patients after bariatric surgery...
July 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29709550/is-the-behavior-of-disc-replacement-adjacent-to-fusion-affected-by-the-location-of-the-fused-level-in-hybrid-surgery
#18
Ting-Kui Wu, Yang Meng, Bei-Yu Wang, Ying Hong, Xin Rong, Chen Ding, Hua Chen, Hao Liu
BACKGROUND: Context: Hybrid surgery (HS), consisting of cervical disc arthroplasty (CDA) at the mobile level, along with anterior cervical discectomy and fusion (ACDF) at the spondylotic level, could be a promising treatment for patients with multilevel cervical degenerative disc disease (DDD). An advantage of this technique is that it utilizes an optimal procedure according to the status of each level. However, information is lacking regarding the influence of the relative location of the replacement and the fusion segment in vivo...
April 27, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29705622/impact-of-resective-epilepsy-surgery-on-health-related-quality-of-life-in-children-with-and-without-low-intellectual-ability
#19
Lauryn Conway, Elysa Widjaja, Mary Lou Smith
OBJECTIVE: The current study examined pre- and postoperative health-related quality of life (HRQL) across children with and without low intellectual ability. We also aimed to clarify the literature on postsurgical change by assessing domain-specific HRQL pre- and postoperatively in children with drug-resistant epilepsy. METHOD: All patients (n=111) underwent resective epilepsy surgery between 1996 and 2016 at the Hospital for Sick Children in Toronto, comparing baseline and 1-year follow-up HRQL with the Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-76)...
April 26, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29702720/patients-screening-positive-for-body-dysmorphic-disorder-show-no-significant-health-related-quality-of-life-gain-after-functional-septorhinoplasty-at-a-tertiary-referral-center
#20
Olcay C Bulut, Frank Wallner, Dare Oladokun, Peter K Plinkert, Ingo Baumann, Ralph Hohenberger
Body dysmorphic disorder (BDD) is a psychiatric disorder defined by an excessive concern about one's physical appearance, especially regarding slight or imagined abnormities of the body. This study was conducted to compare postoperative quality of life (QOL) changes after primary septorhinoplasty among patients screening positive and those screening negative for BDD. Two common instruments for the screening of BDD were used namely the Dysmorphic Concern Questionnaire (DCQ) and the BDD Concern Questionnaire (BDDQ)...
April 27, 2018: Facial Plastic Surgery: FPS
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