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dapsone adverse reactions

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https://www.readbyqxmd.com/read/27871602/hepatotoxicity-due-to-red-bush-tea-consumption-a-case-report
#1
Shamantha Reddy, Pragnyadipta Mishra, Sana Qureshi, Singh Nair, Tracey Straker
Many conventional drugs used today, including isoniazid, dapsone, and acetaminophen, are well recognized culprits of hepatotoxicity. With increasing use of complementary and alternative medical therapies, several herbal medicines, such as Ma-Huang, kava, and chaparral leaf, have been implicated as hepatotoxins. Hepatotoxicity may be the most frequent adverse reaction to these herbal remedies when taken in excessive quantities. A myriad of liver dysfunctions may occur including transient liver enzyme abnormalities due to acute and chronic hepatitis...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27720019/pharmacogenomics-and-adverse-drug-reactions-primetime-and-not-ready-for-primetime-tests
#2
David A Khan
Adverse drug reactions (ADRs) are a relatively common cause of morbidity and mortality. Many factors can contribute to ADRs, including genetics. The degree to which genetics contributes to ADRs is not entirely clear and varies by drug, as well as the type of ADR. Pharmacogenetics and, more recently, pharmacogenomics have been applied to the field of ADRs for both predictable ADRs and hypersensitivity drug reactions. Evaluations for glucose-6-phosphate dehydrogenase and thiopurine S-methyltransferase are commonplace clinical tests to reduce hematologic problems associated with drugs, such as dapsone and azathioprine, respectively...
October 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26999988/early-onset-dapsone-induced-photosensitive-dermatitis-a-rare-side-effect-of-a-common-drug
#3
S Karjigi, S C Murthy, H Kallappa, M R Kusuma, Y N K Reddy
Dapsone, a potent anti-inflammatory compound, is mainly used in the treatment of leprosy, dermatitis herpetiformis, erythema elevatum diutinum and other dermatoses. Cutaneous adverse reactions range from acneiform eruptions to toxic epidermal necrolysis. A 30-year-old, married women who was treated with paucibacillary multi drug therapy, developed itchy skin lesions over the both forearms, 'V ' area of the neck and upper back after one week of the drug administration which worsened on exposure to sunlights...
July 2015: Indian Journal of Leprosy
https://www.readbyqxmd.com/read/25156688/fulminant-hepatitis-linked-to-dapsone-hypersensitivity-syndrome-requiring-urgent-living-donor-liver-transplantation-a-case-report
#4
Angelica Garcia, Nam-Joon Yi, Kyoung Bun Lee, Jeong-Moo Lee, Young Rok Choi, Suk-Won Suh, Tae You, Kwang-Woong Lee, June Dong Park, Hyoung Jin Kang, Joon Gon Kim, Eun Kyeong Kang, Geun Hong, Kyung-Suk Suh
Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT...
November 2014: Pediatric Transplantation
https://www.readbyqxmd.com/read/24791243/mononucleosis-like-drug-rash-an-interesting-case-presentation
#5
Reshma T Vishnani, Ram H Malkani, Afsha A Topal, H G Desai
Dapsone hypersensitivity syndrome (DHS) is a rare adverse effect of the commonly prescribed drug dapsone. We present a case of a 35-year-old male who was referred to us from the gastroenterologist with complaints of rash, nausea, vomiting, and jaundice since 2 days with a provisional differential diagnosis of infectious mononucleosis or viral exanthema. On enquiry patient gave history of taking dapsone a week prior for refractory urticaria. After thorough investigations we diagnosed him with DHS. This syndrome occurs in a relatively small proportion of patients, but it is associated with considerable morbidity and mortality...
January 2014: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/24787710/paediatric-pharmacovigilance-use-of-pharmacovigilance-data-mining-algorithms-for-signal-detection-in-a-safety-dataset-of-a-paediatric-clinical-study-conducted-in-seven-african-countries
#6
Dan K Kajungu, Annette Erhart, Ambrose Otau Talisuna, Quique Bassat, Corine Karema, Carolyn Nabasumba, Michael Nambozi, Halidou Tinto, Peter Kremsner, Martin Meremikwu, Umberto D'Alessandro, Niko Speybroeck
BACKGROUND: Pharmacovigilance programmes monitor and help ensuring the safe use of medicines which is critical to the success of public health programmes. The commonest method used for discovering previously unknown safety risks is spontaneous notifications. In this study we examine the use of data mining algorithms to identify signals from adverse events reported in a phase IIIb/IV clinical trial evaluating the efficacy and safety of several Artemisinin-based combination therapies (ACTs) for treatment of uncomplicated malaria in African children...
2014: PloS One
https://www.readbyqxmd.com/read/24738653/drug-reaction-with-eosinophilia-and-systemic-symptoms-manifestations-treatment-and-outcome-in-17-patients
#7
Sheikh Javeed Sultan, Farah Sameem, Mohd Ashraf
BACKGROUND: Drug-induced hypersensitivity syndrome (DIHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare type of adverse drug reaction with complex clinical features involving multiple systems of the body. OBJECTIVES: This study was designed to evaluate the clinical features, course, response to treatment, and outcome of DRESS. METHODS: The study involved a retrospective analysis of data collected over a period of four years in 17 patients with DRESS...
2015: International Journal of Dermatology
https://www.readbyqxmd.com/read/24175945/comparative-safety-of-artemether-lumefantrine-and-other-artemisinin-based-combinations-in-children-a-systematic-review
#8
REVIEW
Oluwaseun Egunsola, Kazeem A Oshikoya
BACKGROUND: The purpose of the study was to compare the safety of artemether-lumefantrine (AL) with other artemisinin-based combinations in children. METHODS: A search of EMBASE (from 1974 to April 2013), MEDLINE (from 1946 to April 2013) and the Cochrane library of registered controlled trials for randomized controlled trials (RCTs) which compared AL with other artemisinin-based combinations was done. Only studies involving children ≤ 17 years old in which safety of AL was an outcome measure were included...
2013: Malaria Journal
https://www.readbyqxmd.com/read/24097714/prevalence-of-adverse-drug-reactions-with-commonly-prescribed-drugs-in-different-hospitals-of-kathmandu-valley
#9
N Jha, O Bajracharya, T Namgyal
Objectives: To study the prevalence of adverse drug reactions (ADRs) in five different hospitals of Kathmandu Valley. Materials and Methods: An analytical cross sectional study was designed from May 2007 to September 2007 in which prevalence of ADR was calculated. A total of 37 cases of ADRs were taken from 4287 patients and 10% of the remaining population without ADRs i.e. 425 out of 4250 patients was selected randomly. ADRs were analyzed as per the structured questionnaires designed by Canadian adverse drug reaction monitoring program...
October 2007: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/24026795/acute-generalised-exanthematous-pustulosis-induced-by-pneumocystis-jirovecii-pneumonia-prophylaxis-with-dapsone
#10
A Vas, P Laws, Am Marsland, O McQuillan
We describe the case of HIV-1 infected patient presenting to hospital with a severe cutaneous adverse drug reaction shortly after commencing dapsone therapy as Pneumocystis jirovecii pneumonia prophylaxis. To the best of our knowledge, acute generalised exanthematous pustulosis has not been reported as a reaction to dapsone in the setting of HIV.
September 2013: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/24014920/nevirapine-induced-rash-with-eosinophilia-and-systemic-symptoms-dress
#11
Shaman Gill, Amitabh Sagar, S Shankar, Velu Nair
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is an adverse reaction commonly occurring with antiepileptic agents. It was earlier referred to by various names such as dilantin hypersensitivity syndrome and anticonvulsant hypersensitivity syndrome. It is characterized by the triad of fever, skin eruption, and systemic involvement. DRESS syndrome has also been reported with a number of other drugs including allopurinol, minocycline, terbinafine, sulfonamides, azathioprine, dapsone, and antiretroviral agents such as abacavir and nevirapine...
July 2013: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/23855313/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-an-original-multisystem-adverse-drug-reaction-results-from-the-prospective-regiscar-study
#12
MULTICENTER STUDY
S H Kardaun, P Sekula, L Valeyrie-Allanore, Y Liss, C Y Chu, D Creamer, A Sidoroff, L Naldi, M Mockenhaupt, J C Roujeau
BACKGROUND: Cases of severe drug hypersensitivity, demonstrating a variable spectrum of cutaneous and systemic involvement, are reported under various names, especially drug reaction with eosinophilia and systemic symptoms (DRESS). Case definition and overlap with other severe cutaneous adverse reactions (SCAR) are debated. OBJECTIVES: To analyse the spectrum of signs and symptoms of DRESS and distribution of causative drugs in a large multicentre series. PATIENTS AND METHODS: RegiSCAR, a multinational registry of SCAR, prospectively enrolled 201 potential cases from 2003 to mid-2009...
November 2013: British Journal of Dermatology
https://www.readbyqxmd.com/read/23484334/efficacy-of-single-dose-chemotherapy-rifampicin-ofloxacin-and-minocycline-rom-in-pb-leprosy-patients-with-2-to-5-skin-lesions-india-randomised-double-blind-trial
#13
RANDOMIZED CONTROLLED TRIAL
P Manickam, B Nagaraju, V Selvaraj, S Balasubramanyam, V N Mahalingam, S M Mehendale, V K Pannikar, M D Gupte
UNLABELLED: We conducted randomized double-blind trial for single-dose of Rifampicin, Ofloxacin and Minocycline (ROM) compared to WHO-PB-MDT among paucibacillary (PB) leprosy patients with 2-5 skin lesions. We enrolled 1526 patients from five centres (ROM=762; WHO-PB-MDT=764) and followed them for 36 months posttreatment during 1998-2003. We generated information on clearance of skin lesions and relapse rates per 100 person-years (PY) for all the five centres. At base-line, the patients in the two arms were comparable...
July 2012: Indian Journal of Leprosy
https://www.readbyqxmd.com/read/23323115/cervical-lymphadenopathy-mimicking-angioimmunoblastic-t-cell-lymphoma-after-dapsone-induced-hypersensitivity-syndrome
#14
Min Young Rim, Junshik Hong, Inku Yo, Hyeonsu Park, Dong Hae Chung, Jeong Yeal Ahn, Sanghui Park, Jinny Park, Yun Soo Kim, Jae Hoon Lee
A 36-year-old woman presented with erythematous confluent macules on her whole body with fever and chills associated with jaundice after 8 months of dapsone therapy. Her symptoms had developed progressively, and a physical examination revealed bilateral cervical lymphadenopathy and splenomegaly. Excisional biopsy of a cervical lymph node showed effacement of the normal architecture with atypical lymphoid hyperplasia and proliferation of high endothelial venules compatible with angioimmunoblastic T-cell lymphoma...
December 2012: Korean Journal of Pathology
https://www.readbyqxmd.com/read/23130233/an-unusual-case-of-dapsone-syndrome
#15
Mary Grace
Dapsone, a potent antiparasitic and anti-inflammatory compound, is mainly used in the treatment of leprosy and a variety of blistering skin diseases. It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome. We report an unusual case of dapsone hypersensitivity, manifesting as bone marrow suppression and peripheral pancytopenia in addition to fever, rash, and hepatosplenomegaly.
July 2011: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/22960836/oxidative-stress-and-leukocyte-migration-inhibition-response-in-cutaneous-adverse-drug-reactions
#16
Prashant Verma, Sambit Nath Bhattacharya, Basu Deb Banerjee, Naresh Khanna
BACKGROUND: Cutaneous adverse drug reactions (CADRs) may either be immunological or non-immunological. The precise mechanisms, however, are largely obscure. Other concomitant mechanisms may amplify and/or contribute to the severity and duration of a reaction. One such mechanism could be oxidative stress, a state of imbalance between reactive oxygen species, and their subsequent detoxification by antioxidants. AIMS: (a) to assess the oxidative stress status in the blood of cutaneous drug reaction patients by assaying for reduced glutathione (GSH) and malondialdehyde (MDA) levels, (b) to determine the leukocyte migration inhibition (LMI) response in these patients in response to the suspected drug (s), and (c) to look for the association between oxidative stress parameters and LMI...
September 2012: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/22508198/alternative-procedure-to-allow-continuation-of-dapsone-therapy-despite-serious-adverse-reaction-in-a-case-of-dapsone-sensitive-erythema-elevatum-diutinum
#17
REVIEW
Julien Seneschal, Stéphanie Guillet, Khaled Ezzedine, Alain Taïeb, Brigitte Milpied
Dapsone has potent anti-inflammatory effects and remains an effective therapy in a variety of skin disorders: cutaneous vasculitis, neutrophilic dermatoses and blistering disorders. However it may cause a severe idiosyncratic reaction compatible with drug-induced DRESS (drug reaction with eosinophilia and systemic symptoms) leading to the discontinuation of the treatment despite its effectiveness. We report a 68-year-old woman who was successfully treated with dapsone for erythema elevatum diutinum. However she developed a hypersensitivity syndrome compatible with DRESS with fever, skin rash and acute hepatitis confirmed in vitro by the presence of circulating dapsone- specific T cells...
2012: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/22496476/artemether-lumefantrine-an-option-for-malaria
#18
REVIEW
Kayla R Stover, S Travis King, Jessica Robinson
OBJECTIVE: To review the pharmacology, pharmacokinetics, safety, and efficacy of artemether-lumefantrine for the treatment of Plasmodium falciparum malaria. DATA SOURCES: English-language articles indexed in PubMed (1947-November 2011) were identified, using the search terms artemether-lumefantrine, artemether-lumefantrine AND malaria, Coartem, and Coartem AND malaria. STUDY SELECTION AND DATA EXTRACTION: Available English-language articles were reviewed...
April 2012: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/22307940/hypersensitivity-reactions-to-dapsone-a-systematic-review
#19
REVIEW
Maria Lorenz, Gottfried Wozel, Jochen Schmitt
Dapsone is widely used in the treatment of leprosy and several chronic inflammatory dermatological conditions. Hypersensitivity reactions to dapsone are potentially fatal adverse drug reactions with unknown prevalence and risk factors. We performed a systematic review covering all reported cases of hypersensitivity reactions, in order to systematically summarize the published evidence on prevalence, clinical course and fatality rate. Articles were identified through standardized search strategies. Included studies were reviewed for hypersensitivity characteristics and odds ratios were calculated in univariate and multivariate regression models to assess the risk factors for fatal outcome...
March 2012: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/21829418/dapsone-hypersensitivity-syndrome-causing-disseminated-intravascular-coagulation
#20
Melanie Clare Figtree, Spiros Miyakis, Kumiko Tanaka, Linda Martin, Pam Konecny, Steven Krilis
Dapsone hypersensitivity syndrome is an idiosyncratic reaction to this drug and can present with different clinical manifestations of varying severity. We describe a patient with disseminated intravascular coagulation (DIC) as an adverse reaction to dapsone. To the best of our knowledge, this is the first time it has been described in the literature. She presented with fever, rash and abdominal pain; she also had marked eosinophilia and features suggestive of oxidative haemolysis. Her course was complicated by DIC, splenic infarction and gastrointestinal bleeding...
2009: BMJ Case Reports
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