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https://www.readbyqxmd.com/read/29050130/-evaluation-of-a-high-intensity-fluorescent-fluorophage-method-for-diagnosis-of-drug-resistance-in-tuberculosis
#1
J J Luo, X Yu, Y F Ma, L P Zhao, Y Y Shang, Y Y Fu, H R Huang
Objective: To evaluate the high-intensity green fluorescent protein fluorophage Φ(2)GFP10 method for drug susceptibility testing of tuberculosis for isoniazid(INH), rifampin(RIF), and streptomycin(SM). Methods: A total of 128 clinical M. tuberculosis strains were isolated from patients with suspected drug-resistant tuberculosis visiting Beijing Chest Hospital (Beijing, China) from April to June 2014.All of the isolates were tested by the phage assay, while conventional drug susceptibility tests were performing on Lwenstein-Jensen culture medium as reference...
October 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29049821/mainstreaming-latent-tuberculosis-infection-testing-and-treatment-in-the-united-states-who-and-how
#2
Jennifer Flood, Pennan M Barry
No abstract text is available yet for this article.
October 16, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29049814/cost-effectiveness-of-testing-and-treatment-for-latent-tuberculosis-infection-in-residents-born-outside-the-united-states-with-and-without-medical-comorbidities-in-a-simulation-model
#3
Abriana Tasillo, Joshua A Salomon, Thomas A Trikalinos, C Robert Horsburgh, Suzanne M Marks, Benjamin P Linas
Importance: Testing for and treating latent tuberculosis infection (LTBI) is among the main strategies to achieve TB elimination in the United States. The best approach to testing among non-US born residents, particularly those with comorbid conditions, is uncertain. Objective: To estimate health outcomes, costs, and cost-effectiveness of LTBI testing and treatment among non-US born residents with and without medical comorbidities. Design, Setting, and Participants: Decision analytic tree and Markov cohort simulation model among non-US born residents with no comorbidities, with diabetes, with HIV infection, or with end-stage renal disease (ESRD) using a health care sector perspective with 3% annual discounting...
October 16, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29049400/spoligotyping-and-whole-genome-sequencing-analysis-of-lineage-1-strains-of-mycobacterium-tuberculosis-in-da-nang-vietnam
#4
Minako Hijikata, Naoto Keicho, Le Van Duc, Shinji Maeda, Nguyen Thi Le Hang, Ikumi Matsushita, Seiya Kato
BACKGROUND: Spacer oligonucleotide typing (spoligotyping), a widely used, classical genotyping method for Mycobacterium tuberculosis complex (MTBC), is a PCR-based dot-blot hybridization technique to detect the genetic diversity of the direct repeat (DR) region. Of the seven major MTBC lineages in the world, lineage 1 (Indo-Oceanic) mostly corresponds to the East African-Indian (EAI) spoligotype family in East Africa and Southeast Asia. OBJECTIVES: We investigated the genomic features of Vietnamese lineage 1 strains, comparing spoligotype patterns using whole-genome sequencing (WGS) data...
2017: PloS One
https://www.readbyqxmd.com/read/29049397/the-transcriptional-regulator-lysg-rv1985c-of-mycobacterium-tuberculosis-activates-lyse-rv1986-in-a-lysine-dependent-manner
#5
Marie Schneefeld, Tobias Busche, Robert Geffers, Jörn Kalinowski, Franz-Christoph Bange
The Mycobacterium tuberculosis protein encoded by the Rv1986 gene is a target for memory T cells in patients with tuberculosis, and shows strong similarities to a lysine exporter LysE of Corynebacterium glutamicum. During infection, the pathogen Mycobacterium tuberculosis adapts its metabolism to environmental changes. In this study, we found that the expression of Rv1986 is controlled by Rv1985c. Rv1985c is located directly upstream of Rv1986 with an overlapping promoter region between both genes. Semiquantitative reverse transcription PCR using an isogenic mutant of Mycobacterium tuberculosis lacking Rv1985c showed that in the presence of lysine, Rv1985c protein positively upregulated the expression of Rv1986...
2017: PloS One
https://www.readbyqxmd.com/read/29049243/rare-case-of-pulmonary-lymphomatoid-granulomatosis-in-conjunction-with-tuberculosis-a-case-report
#6
Young Woo Ha, Chul Hwan Kim, Yong Park, Jang Wook Sohn, Min Ja Kim, Young Kyung Yoon
RATIONALE: Lymphomatoid granulomatosis is a very rare Epstein-Barr virus-driven lymphoproliferative disease. This disease has high mortality owing to its low incidence in conjunction with nonspecific presentations, which contribute to delays in diagnosis. PATIENT: An 87-year-old male had a week-long history of intermittent fever and general weakness. A chest radiograph showed multifocal patchy consolidations with nodular lesions. DIAGNOSES: Open lung biopsy using video-assisted thoracic surgery resulted in a diagnosis of grade III lymphomatoid granulomatosis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048873/insights-into-mycobacteria-interactions-with-the-host-innate-immune-system-from-a-novel-array-of-synthetic-mycobacterial-glycans
#7
Ruixiang Blake Zheng, Sabine A F Jégouzo, Maju Joe, Yu Bai, Huu-Anh Tran, Ke Shen, Jörn Saupe, Li Xia, Md Faiaz Ahmed, Yu-Hsuan Liu, Pratap Subhashrao Patil, Ashish Tripathi, Shang-Cheng Hung, Maureen E Taylor, Todd L Lowary, Kurt Drickamer
An array of homogenous glycans representing all the major carbohydrate structures present in the cell wall of the human pathogen Mycobacterium tuberculosis and other mycobacteria has been probed with a panel of glycan-binding receptors expressed on cells of the mammalian innate immune system. The results provide an overview of interactions between mycobacterial glycans and receptors that mediate uptake and survival in macrophages, dendritic cells and sinusoidal endothelial cells. A subset of the wide variety of glycan structures present on mycobacterial surfaces interact with cells of the innate immune system through the receptors tested...
October 19, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29048512/excellent-treatment-outcomes-in-children-treated-for-tuberculosis-under-routine-operational-conditions-in-cape-town-south-africa
#8
Muhammad Osman, Kevin Lee, Karen Du Preez, Rory Dunbar, Anneke C Hesseling, James A Seddon
Background: Tuberculosis (TB) remains a leading cause of death in children globally. It is recognized that human immunodeficiency virus (HIV) infection increases the risk of developing TB, but our understanding of the impact of HIV on risk of mortality for children treated for TB is limited. We aimed to identify predictors of mortality in children treated for drug-susceptible TB. Methods: A retrospective analysis of all children (<15 years of age) routinely treated between 2005 and 2012 for drug-susceptible TB in Cape Town was conducted using the programmatic electronic TB treatment database...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29048475/in-vitro-infection-with-mycobacterium-tuberculosis-induces-a-distinct-immunological-pattern-in-blood-from-healthy-relatives-of-tuberculosis-patients
#9
Javier Juan-García, Silvia García-García, José Manuel Guerra-Laso, Sara Raposo-García, Cristina Diez-Tascón, Teresa Nebreda-Mayoral, Eduardo López-Fidalgo, Ramiro López-Medrano, Araceli Fernández-Maraña, Octavio Miguel Rivero-Lezcano
Part of the susceptibility to tuberculosis has a genetic basis, which is clear in primary immunodeficiencies, but is less evident in apparently immunocompetent subjects. Immune responses were analysed in blood samples from tuberculosis patients and their healthy first-degree relatives who were infected in vitro with mycobacteria (either Mycobacterium tuberculosis or M. bovis BCG). The antimicrobial activity against M. tuberculosis in blood from relatives was significantly lower than that observed in healthy controls...
October 10, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29048297/polyclonal-pulmonary-tuberculosis-infections-and-risk-for-multidrug-resistance-lima-peru
#10
Ruvandhi R Nathavitharana, Cynthia X Shi, Leonid Chindelevitch, Roger Calderon, Zibiao Zhang, Jerome T Galea, Carmen Contreras, Rosa Yataco, Leonid Lecca, Mercedes C Becerra, Megan B Murray, Ted Cohen
Because within-host Mycobacterium tuberculosis diversity complicates diagnosis and treatment of tuberculosis (TB), we measured diversity prevalence and associated factors among 3,098 pulmonary TB patients in Lima, Peru. The 161 patients with polyclonal infection were more likely than the 115 with clonal or the 2,822 with simple infections to have multidrug-resistant TB.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29047424/drug-resistant-tuberculosis-among-children-china-2006-2015
#11
Ning-Ning Tao, Xiao-Chun He, Xian-Xin Zhang, Yao Liu, Chun-Bao Yu, Huai-Chen Li
Microbial drug resistance has become a major public health concern worldwide. To acquire epidemiologic data on drug-resistant tuberculosis (DR TB) among children, a major cause of illness and death for this population, we conducted a retrospective study of 2006-2015 data from 36 TB prevention and control institutions in Shandong Province, China. A total of 14,223 new TB cases, among which children (<18 years of age) accounted for only 5.5%, were caused by culture-confirmed Mycobacterium tuberculosis. Among children with TB, 18...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29047275/excipient-free-pulmonary-delivery-and-macrophage-targeting-of-clofazimine-via-air-jet-micronization
#12
Ashlee D Brunaugh, Syed Umer Jan, Silvia Ferrati, Hugh D C Smyth
Clofazimine (CFZ) is highly active against mycobacterium, including resistant Mycobacterium tuberculosis, but its therapeutic efficacy via the oral route is limited by severe adverse effects, poor aqueous solubility, and slow onset of action. Pulmonary delivery of CFZ is an attractive alternative to target mycobacterium-harboring alveolar macrophages. This study explores the use of air jet milling to develop a respirable, cost-effective CFZ formulation. Jet milled CFZ was readily dispersed from an off-the-shelf dry powder inhaler without the need for additional excipients or carrier particles...
October 19, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29046753/melioidosis-the-great-mimicker
#13
Mandeep Singh, Mehvish Mahmood
Melioidosis is an infectious disease endemic in Northern Australia and South East Asia. It is associated with high degrees of morbidity and mortality. On average, around five cases are diagnosed annually in the USA. Diagnosis remains a challenge, as it mimics many other conditions, especially tuberculosis, hence its other name, the 'great mimicker.' The present case involves a recent traveler to the Philippines, who presented with episodic fevers and weight loss to his primary care physician. Blood cultures ordered grew Burkholderia pseudomallei...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29046674/tbvac2020-advancing-tuberculosis-vaccines-from-discovery-to-clinical-development
#14
REVIEW
Stefan H E Kaufmann, Hazel M Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H M Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A W Verreck, Ann Williams
TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The project builds on previous collaborations from 1998 onwards funded through the EC framework programs FP5, FP6, and FP7. It has succeeded in attracting new partners from outstanding laboratories from all over the world, now totaling 40 institutions. Next to the development of novel vaccines, TB biomarker development is also considered an important asset to facilitate rational vaccine selection and development...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29046413/prediction-of-local-transmission-of-mycobacterium-tuberculosis-isolates-of-a-predominantly-beijing-lineage-using-a-variable-number-tandem-repeat-vntr-typing-method-incorporating-a-consensus-set-of-hypervariable-loci
#15
Yoshiro Murase, Kiyohiko Izumi, Akihiro Ohkado, Akio Aono, Kinuyo Chikamatsu, Hiroyuki Yamada, Yuriko Igarashi, Akiko Takaki, Satoshi Mitarai
Strain genotyping based on the variable-number tandem repeat (VNTR) is widely applied for identifying the transmission of Mycobacterium tuberculosis A consensus set of four hypervariable loci (1982, 3232, 3820, and 4120) has been proposed to improve the discrimination of Beijing lineage strains. Herein, we evaluated the utility of these four hypervariable loci for tracing local tuberculosis transmission in 981 cases over a 14-month period in Japan (2010--2011). We used six different VNTR systems, with or without the four hypervariable loci...
October 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29046306/a-novel-yeast-based-therapeutic-vaccine-for-tuberculosis-gi-19007
#16
Thomas H King, Crystal A Shanley, Zhimin Guo, Donald Bellgrau, Timothy Rodell, Synthia Furney, Marcela Henao-Tamayo, Ian M Orme
As yet, very few vaccine candidates with activity in animals against Mycobacterium tuberculosis infection have been tested as therapeutic "post-exposure" vaccines. We recently described two pools of mycobacterial proteins with this activity and here we describe further studies in which four of these proteins (Rv1738, Rv2032, Rv3130, and Rv3841) were generated as a fusion polypeptide, and then delivered in a novel yeast-based platform ("Tarmogen®") which itself has immunostimulatory properties including activation of Toll-like receptors...
October 18, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/29046251/mycobacterium-tuberculosis-esat6-induces-ifn-%C3%AE-gene-expression-in-macrophages-via-tlrs-mediated-signaling
#17
Ah-Ra Jang, Joo-Hee Choi, Sung Jae Shin, Jong-Hwan Park
Mycobacterium tuberculosis is a highly virulent bacterium that causes tuberculosis. It infects about one third of the world's population. Type I interferons (IFNs) play a detrimental role in host defense against M. tuberculosis infection. Proteins secreted by M. tuberculosis through ESX-1 secretion system contribute to type I IFNs production. However, the precise mechanism by which 6-kDa early secretory antigen target (ESAT6), one of ESX-1-mediated secretory proteins, induces type I IFNs production in host cells is currently unclear...
October 15, 2017: Cytokine
https://www.readbyqxmd.com/read/29046010/-differential-diagnosis-of-mediastinal-and-hilar-lymphadenopathy-with-focus-on-occupational-diseases
#18
H Lux, L Barreira Cavalcante, X Baur
Hilar and mediastinal lymphadenopathy may represent a diagnostic challenge in clinical practice. This article is intended to facilitate differential diagnosis by a systematic description of relevant pathologies, notably with occupational etiology. Clinical findings of relevant diseases, i. e. of tuberculosis, chronic beryllium disease, sarcoidosis, lung cancer, malignant lymphoma, Epstein-Barr virus infection, and histoplasmosis are compared.Case history, imaging and laboratory tests have important diagnostic impact...
October 18, 2017: Pneumologie
https://www.readbyqxmd.com/read/29045910/immunogenicity-and-protective-efficacy-of-multistage-vaccine-candidates-mtb8-4-hspx-and-hspx-mtb8-4-against-mycobacterium-tuberculosis-infection-in-mice
#19
Wanbo Liu, Jingjing Li, Hongxia Niu, Xiaofa Lin, Ruiying Li, Yue Wang, Qi Xin, Hongjuan Yu, Yumin Wu, Bingdong Zhu, Jiying Tan
In this study, Mtb8.4 and HspX, which are expressed at proliferating and dormant stages of Mycobacterium tuberculosis (M. tuberculosis), respectively, were chosen to construct two fusion proteins, Mtb8.4-HspX (8.4H) and HspX-Mtb8.4 (H8.4), and we investigated whether the antigen dose and protein sequential order could impact the immunogenicity and protective efficacy of these fusion protein vaccines against M. tuberculosis. C57BL/6 mice were vaccinated with new constructions containing a fusion protein with adjuvant of N, N'-dimethyl-N, N'-dioctadecylammonium bromide (DDA) or a mixed adjuvant composed of DDA, polyribocytidylic acid and gelatin (DPG), and the antigen specific immune responses and protective efficacy against M...
October 15, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29045278/angulated-stents-a-novel-stent-improvisation-to-manage-difficult-post-tuberculosis-bronchial-stenosis
#20
Chee Kiang Tay, Byeong-Ho Jeong, Hojoong Kim
Post-tuberculosis bronchostenosis (PTBS), a complication of endobronchial tuberculosis is currently treated by bronchial stenting. However, in cases of angulated bronchial stenoses, difficulty is often encountered in stent insertion and maintenance, resulting in stent migration, granulation tissue overgrowth, and restenosis. To accommodate the angulated alignment of the stenosis, we devised an "angulated stent"-a novel improvisation of the conventional stent via splicing and suturing to achieve a resultant angulated shape...
October 18, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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