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HPV Vitamin A

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https://www.readbyqxmd.com/read/27730031/evolving-role-of-immunotherapy-in-the-treatment-of-refractory-warts
#1
Devinder M Thappa, Minu J Chiramel
Cutaneous and genital warts are common dermatological conditions caused by the human papilloma virus (HPV). Although it is a benign condition, it causes disfigurement, has a tendency to koebnerize, and can be transmitted to others. This makes adequate and timely treatment important. There are several conventional treatments available with variable response. Topical and systemic immunotherapy has now found a significant place in the treatment of warts because of its nondestructive action, ease of use, and promising results...
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27588159/worldwide-cutaneous-malignant-melanoma-incidences-analyzed-by-sex-age-and-skin-type-over-time-1955-2007-is-hpv-infection-of-androgenic-hair-follicular-melanocytes-a-risk-factor-for-developing-melanoma-exclusively-in-people-of-european-ancestry
#2
Stephen J Merrill, Madhan Subramanian, Dianne E Godar
The cutaneous malignant melanoma (CMM) incidence has been increasing in an exponential manner in certain populations around the world for over 7 decades. To help illuminate the etiology, we performed worldwide temporal (1955-2007) CMM incidence analysis by sex, age (0-14, 15-29, 30-49, 50-69, 70-85+), and skin type on 6 continents using data from the International Agency for Research on Cancer. We observe an exponential increase in the CMM incidence over time and an increase of about 2 orders of magnitude between age groups 0-14 and 15-29 exclusively in European-ancestry populations around the world independent of skin type (I-III or III-IV)...
January 2016: Dermato-endocrinology
https://www.readbyqxmd.com/read/27244952/optimal-dose-of-vitamin-d3-400-i-u-for-average-adults-has-a-significant-anti-cancer-effect-while-widely-used-2000-i-u-or-higher-promotes-cancer-marked-reduction-of-taurine-1%C3%AE-25-oh-2d3-was-found-in-various-cancer-tissues-and-oral-intake-of-optimal-dose-of-taurine
#3
Yoshiaki Omura, Dominic Lu, Marilyn K Jones, Abdallah Nihrane, Harsha Duvvi, Dario Yapor, Yasuhiro Shimotsuura, Motomu Ohki
During the past 10 years, the author had found that the optimal dose of Vitamin D3 400 I.U. has safe & effective anticancer effects, while commonly used 2000-5000 I.U. of Vit. D3 often creates a 2-3 time increase in cancer markers. We examined the concentration of Taurine in normal internal organs and in cancer using Bi-Digital O-Ring Test. We found that Taurine levels in normal tissue are 4-6ng. But, the amount of Taurine of average normal value of 5.0-5.25ng was strikingly reduced to 0.0025-0.0028ng in this study of several examples in adenocarcinomas of the esophagus, stomach, pancreas, colon, prostate, and lung, as well as breast cancer...
2016: Acupuncture & Electro-therapeutics Research
https://www.readbyqxmd.com/read/27207583/decreased-rar%C3%AE-expression-induces-abundant-inflammation-and-cervical-precancerous-lesions
#4
M E Albino-Sanchez, J Vazquez-Hernandez, R Ocadiz-Delgado, N Serafin-Higuera, I León-Galicia, E Garcia-Villa, R Hernandez-Pando, P Gariglio
It is well known that vitamin A and its receptors protect against cancer development and that Retinoid Acid Receptor β (RARβ) is epigenetically silenced during tumoral progression. Cervical Cancer (CC) has been causally linked to high risk human papillomavirus (HR-HPV) infection. However, host factors are important in determining the outcome of persistent HR-HPV infection as most cervical precancerous lesions containing HR-HPVs do not progress to invasive carcinomas. Increasing evidence suggests that low diet in vitamin A and their receptors participate in the development of CC...
August 1, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27091196/vitamin-k3-induces-antiproliferative-effect-in-cervical-epithelial-cells-transformed-by-hpv-16-siha-cells-through-the-increase-in-reactive-oxygen-species-production
#5
Natália de Carvalho Scharf Santana, Natália Alves Lima, Vânia Cristina Desoti, Danielle Lazarin Bidóia, Patrícia de Souza Bonfim Mendonça, Bianca Altrão Ratti, Tânia Ueda Nakamura, Celso Vataru Nakamura, Marcia Edilaine Lopes Consolaro, Valdecir Farias Ximenes, Sueli de Oliveira Silva
PURPOSE: Cervical cancer is characterized as an important public health problem. According to latest estimates, cancer of the cervix is the fourth most common cancer among women. Due to its high prevalence, the search for new and efficient drugs to treat this infection is continuous. The progression of HPV-associated cervical cancer involves the expression of two viral proteins, E6 and E7, which are rapidly degraded by the ubiquitin-proteasome system through the increase in reactive oxygen species generation...
October 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/26946790/-2015-literature-findings-in-general-internal-medicine
#6
REVIEW
David Barras, Élodie Saillen, Éric Mercier, Sophie Zürcher, Alexandre Gouveia, André Liaudet, Sophie Guinand, Olivier Pasche, Roane Keller, Patrick Bodenmann
Benzodiazepines are associated with the risk of developing Alzheimer's disease. Systematic dosage and vitamin D substitution have no place in times of immediate post-menopause. Topical placebos challenge analgesics in the treatment of knee osteoarthritis. Palliative chemotherapy does not improve life-quality at the end of life. Restrictive transfusion thresholds entail no risk. Spirometry should always be performed before the initiation of a long-term bronchodilator therapy. Practitioners continue to overprescribe antibiotics for infections of the upper respiratory tract...
January 20, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/26878091/longitudinal-biobanks-based-study-on-the-joint-effects-of-infections-nutrition-and-hormones-on-risk-of-prostate-cancer
#7
Sonja Lumme, Leena Tenkanen, Hilde Langseth, Randi Gislefoss, Matti Hakama, Pär Stattin, Göran Hallmans, Herman Adlercreutz, Pekka Saikku, Ulf-Håkan Stenman, Pentti Tuohimaa, Tapio Luostarinen, Joakim Dillner
Background To evaluate the individual and combined effects of enterolactone, vitamin D, free testosterone, Chlamydia trachomatis and HPV-18 on the risk of prostate cancer in a large population-based biochemical material that combined three Nordic serum sample banks. Material and methods A joint cohort of 209 000 healthy men was followed using cancer registry linkages. From this cohort altogether 699 incident cases of prostate cancer were identified. Four controls were selected by incidence density sampling and matching for country, age and date of the blood sampling...
July 2016: Acta Oncologica
https://www.readbyqxmd.com/read/26827959/metabolism-and-action-of-25-hydroxy-19-nor-vitamin-d%C3%A2-in-human-prostate-cells
#8
Eiji Munetsuna, Atsushi Kittaka, Tai C Chen, Toshiyuki Sakaki
Since the discovery of 1α,25(OH)2D3 in the early 1970s, it has been widely accepted that this metabolite is responsible for the biological actions of vitamin D. Likewise, we have assumed that 25(OH)-19-nor-D3-dependent growth inhibition of human prostate PZ-HPV-7 cells was the result of its subsequent conversion to 1α,25(OH)2-19-nor-D3, catalyzed by CYP27B1 within the prostate cells. However, further in vitro studies in a reconstituted system using recombinant CYP27B1 revealed that 25(OH)-19-nor-D3 was hardly converted to 1α,25(OH)2-19-nor-D3 by the enzyme...
2016: Vitamins and Hormones
https://www.readbyqxmd.com/read/26413188/exponentially-increasing-incidences-of-cutaneous-malignant-melanoma-in-europe-correlate-with-low-personal-annual-uv-doses-and-suggests-2-major-risk-factors
#9
Stephen J Merrill, Samira Ashrafi, Madhan Subramanian, Dianne E Godar
For several decades the incidence of cutaneous malignant melanoma (CMM) steadily increased in fair-skinned, indoor-working people around the world. Scientists think poor tanning ability resulting in sunburns initiate CMM, but they do not understand why the incidence continues to increase despite the increased use of sunscreens and formulations offering more protection. This paradox, along with lower incidences of CMM in outdoor workers, although they have significantly higher annual UV doses than indoor workers have, perplexes scientists...
January 2015: Dermato-endocrinology
https://www.readbyqxmd.com/read/25834528/feasibility-of-delivering-hpv-vaccine-to-girls-aged-10-to-15-years-in-uganda
#10
Emmanuel Mugisha, D Scott LaMontagne, Anne R Katahoire, Daniel Murokora, Edward Kumakech, Rachel Seruyange, Vivien Davis Tsu
BACKGROUND: Cervical cancer is a leading cause of mortality among women in Uganda. The availability of the human papillomavirus (HPV) vaccine presents an opportunity to prevent cervical cancer. The Government of Uganda conducted a demonstration project exploring the feasibility of two delivery strategies. OBJECTIVE: To explore the feasibility of two HPV vaccine delivery strategies: 1) a stand-alone school-based strategy that selected girls based on their enrolment in grade 5 (known as the "grade-based" strategy; and 2) an age-based strategy that delivered the HPV vaccine based on the girls' age (10-year-olds)...
March 2015: African Health Sciences
https://www.readbyqxmd.com/read/25712051/fenretinide-perturbs-focal-adhesion-kinase-in-premalignant-and-malignant-human-oral-keratinocytes-fenretinide-s-chemopreventive-mechanisms-include-ecm-interactions
#11
Byungdo B Han, Suyang Li, Meng Tong, Andrew S Holpuch, Richard Spinney, Daren Wang, Michael B Border, Zhongfa Liu, Sachin Sarode, Ping Pei, Steven P Schwendeman, Susan R Mallery
The membrane-associated protein, focal adhesion kinase (FAK), modulates cell-extracellular matrix interactions and also conveys prosurvival and proliferative signals. Notably, increased intraepithelial FAK levels accompany transformation of premalignant oral intraepithelial neoplasia (OIN) to oral squamous cell carcinoma (OSCC). OIN chemoprevention is a patient-centric, optimal strategy to prevent OSCC's comorbidities and mortality. The cancer chemopreventive and synthetic vitamin A derivative, fenretinide, has demonstrated protein-binding capacities, for example, mTOR- and retinol-binding protein interactions...
May 2015: Cancer Prevention Research
https://www.readbyqxmd.com/read/25547101/is-there-a-role-for-antioxidants-in-the-prevention-of-infection-associated-carcinogenesis-and-in-the-treatment-of-infection-driven-tumors
#12
Chiara De Luca, Zaira Kharaeva, Liudmila Korkina
Causative connections between infections and cancer are ascertained for several types of viruses, bacteria, and parasites. The mechanisms of cancer induction in chronically infected inflamed tissues strongly implicate oxygen- and nitrogen-centered reactive species, and an impairment of redox-sensitive molecular pathways involved in the tumorigenic transformation, tumor growth, altered immune defense, and in the mechanisms of tumor cell death and survival. Here, we briefly reviewed mechanistic data on carcinogenesis and tumor progression of three major infection-associated tumors, human papillomavirus-induced cervical cancer, hepatitis B virus-positive hepatocarcinoma, and Helicobacter pylori-positive gastric cancer...
December 29, 2014: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/25496269/is-there-a-role-for-antioxidants-in-the-prevention-of-infection-associated-carcinogenesis-and-in-the-treatment-of-infection-driven-tumors
#13
Chiara De Luca, Zaira Kharaeva, Liudmila Korkina
Causative connections between infections and cancer are ascertained for several types of viruses, bacteria, and parasites. The mechanisms of cancer induction in chronically infected inflamed tissues strongly implicate oxygen- and nitrogen-centered reactive species, and an impairment of redox-sensitive molecular pathways involved in the tumorigenic transformation, tumor growth, altered immune defense, and in the mechanisms of tumor cell death and survival. Here, we briefly reviewed mechanistic data on carcinogenesis and tumor progression of three major infection-associated tumors, human papillomavirus-induced cervical cancer, hepatitis B virus-positive hepatocarcinoma, and Helicobacter pylori-positive gastric cancer...
2015: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/25447808/pathophysiology-of-ocular-surface-squamous-neoplasia
#14
REVIEW
Stephen Gichuhi, Shin-ichi Ohnuma, Mandeep S Sagoo, Matthew J Burton
The incidence of ocular surface squamous neoplasia (OSSN) is strongly associated with solar ultraviolet (UV) radiation, HIV and human papilloma virus (HPV). Africa has the highest incidence rates in the world. Most lesions occur at the limbus within the interpalpebral fissure particularly the nasal sector. The nasal limbus receives the highest intensity of sunlight. Limbal epithelial crypts are concentrated nasally and contain niches of limbal epithelial stem cells in the basal layer. It is possible that these are the progenitor cells in OSSN...
December 2014: Experimental Eye Research
https://www.readbyqxmd.com/read/25422218/folate-deficiency-and-fhit-hypermethylation-and-hpv-16-infection-promote-cervical-cancerization
#15
COMPARATIVE STUDY
Li-Xia Bai, Jin-Tao Wang, Ling Ding, Shi-Wen Jiang, Hui-Jie Kang, Chen-Fei Gao, Xiao Chen, Chen Chen, Qin Zhou
Fragile histidine triad (FHIT) is a suppressor gene related to cervical cancer through CpG island hypermethylation. Folate is a water-soluble B-vitamin and an important cofactor in one-carbon metabolism. It may play an essential role in cervical lesions through effects on DNA methylation. The purpose of this study was to observe effects of folate and FHIT methylation and HPV 16 on cervical cancer progression. In this study, DNA methylation of FHIT, serum folate level and HPV16 status were measured using methylation-specific polymerase chain reaction (MSP), radioimmunoassay (RIA) and polymerase chain reaction (PCR), respectively, in 310 women with a diagnosis of normal cervix (NC, n=109), cervical intraepithelial neoplasia (CIN, n=101) and squamous cell carcinoma of the cervix (SCC, n=101)...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25411259/lack-of-association-between-serum-25-hydroxyvitamin-d-levels-and-cervical-human-papillomavirus-infection-in-systemic-lupus-erythematosus
#16
M García-Carrasco, C Mendoza-Pinto, P Munguía-Realpozo, A Rodríguez-Gallegos, V Vallejo-Ruiz, M Muñoz-Guarneros, S Méndez-Martínez, P Soto-Santillán, E Pezzat-Said, J Reyes-Leyva, A López-Colombo, A Ruiz-Argüelles, R Cervera
Our objective was to evaluate whether vitamin D deficiency is associated with cervical human papilloma virus (HPV) infection in women with SLE. This is a cross-sectional study of 67 women with SLE. A structured questionnaire was administered to ascertain the possible risk factors associated with cervical HPV infection. A gynaecological evaluation and cervical cytology screening were made. HPV detection and genotyping was made by PCR and linear array assay. Serum 25 hydroxyvitamin D levels were quantified by chemiluminescence immunoassay...
May 2015: Lupus
https://www.readbyqxmd.com/read/25145486/folate-and-vitamin-b12-may-play-a-critical-role-in-lowering-the-hpv-16-methylation-associated-risk-of-developing-higher-grades-of-cin
#17
Chandrika J Piyathilake, Maurizio Macaluso, Michelle M Chambers, Suguna Badiga, Nuzhat R Siddiqui, Walter C Bell, Jeffrey C Edberg, Edward E Partridge, Ronald D Alvarez, Gary L Johanning
We previously reported that a higher degree of methylation of CpG sites in the promoter (positions 31, 37, 43, 52, and 58) and enhancer site 7862 of human papillomavirus (HPV) 16 was associated with a lower likelihood of being diagnosed with HPV 16-associated CIN 2+. The purpose of this study was to replicate our previous findings and, in addition, to evaluate the influence of plasma concentrations of folate and vitamin B12 on the degree of HPV 16 methylation (HPV 16m). The study included 315 HPV 16-positive women diagnosed with either CIN 2+ or ≤CIN 1...
November 2014: Cancer Prevention Research
https://www.readbyqxmd.com/read/24848140/serum-one-carbon-metabolites-and-risk-of-cervical-cancer
#18
Sujata Pathak, Deepti Bajpai, Ayan Banerjee, Neerja Bhatla, Sunesh Kumar Jain, Hiremagular N Jayaram, Neeta Singh
Most cases of cervical cancer are associated with human papilloma virus (HPV) infection of high risk types. In folate deficiency, heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) interferes with HPV16 viral capsid protein synthesis. We aimed to study the importance of 1-carbon metabolism in cervical carcinogenesis by examining serum vitamin B12 (cobalamin), homocysteine, folate levels, and the RNA and protein expression of HPV16 L1, L2, E6, E7, and to correlate them with hnRNP-E1 expression and HPV infection in normals, squamous intraepithelial lesions (SILs), and cervical cancer subjects...
2014: Nutrition and Cancer
https://www.readbyqxmd.com/read/24643189/management-of-human-papillomavirus-related-gynecological-malignancies
#19
Viola A Heinzelmann-Schwarz, André B Kind, Francis Jacob
Human papillomavirus (HPV) infections affect women in every age group and in various benign, premalignant as well as malignant gynecological conditions. As a benign condition, condylomata acuminata of the whole female genital tract can be observed, transmitted by low risk HPV types 6 and 11, whilst dysplastic changes of the vulva appear as vulvar intraepithelial neoplasia, of the vagina as vaginal intraepithelial neoplasia and of the cervix as cervical intraepithelial neoplasia, and are caused by high risk HPV types most notably 16 and 18...
2014: Current Problems in Dermatology
https://www.readbyqxmd.com/read/24535953/potent-antiproliferative-effects-of-25-hydroxy-16-ene-23-yne-vitamin-d%C3%A2-that-resists-the-catalytic-activity-of-both-cyp27b1-and-cyp24a1
#20
Steve Y Rhieu, Andrew J Annalora, Erika LaPorta, JoEllen Welsh, Toshimasa Itoh, Keiko Yamamoto, Toshiyuki Sakaki, Tai C Chen, Milan R Uskokovic, G Satyanarayana Reddy
The potency of 25-hydroxyvitamin D3 (25(OH)D3) is increased by several fold through its metabolism into 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) by cytochrome P450 27B1 (CYP27B1). Thus, the pivotal role of 1α-hydroxylation in the activation of vitamin D compounds is well known. Here, we examined the metabolism of 25-hydroxy-16-ene-23-yne-vitamin D3 (25(OH)-16-ene-23-yne-D3), a synthetic analog of 25(OH)D3 in a cell-free system and demonstrated that 25(OH)-16-ene-23-yne-D3 is neither activated by CYP27B1 nor inactivated by cytochrome P450 24A1 (CYP24A1)...
August 2014: Journal of Cellular Biochemistry
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