keyword
https://read.qxmd.com/read/36986338/preventing-persistence-of-hpv-infection-with-natural-molecules
#1
REVIEW
Antonio Simone Laganà, Vito Chiantera, Sandro Gerli, Sara Proietti, Elisa Lepore, Vittorio Unfer, Jose Carugno, Alessandro Favilli
Human papillomavirus (HPV) infection is one the most common sexually transmitted infections worldwide. In most cases, the infection is temporary and asymptomatic; however, when persistent, it may lead to lesions that can evolve into cancer in both women and men. Nowadays, prophylactic vaccination is the primary preventive strategy for HPV infections, but vaccines do not cover all types of HPV strains. Scientific research has uncovered the beneficial role of some natural supplements in preventing persistent HPV infections or treating HPV-related lesions...
March 6, 2023: Pathogens
https://read.qxmd.com/read/36537109/injectable-catechin-based-supramolecular-hydrogel-for-highly-efficient-application-in-hpv-associated-oscc
#2
JOURNAL ARTICLE
Shangxue Lei, Xiaopei Hu, Shaojuan Song, Yuting Zhang, Hang Zhao, Xiaoping Xu, Hongxia Dan
Catechins are a group of natural polyphenols extracted from green tea. Notably, they have been proven to have excellent anti-HPV and anti-tumour properties and to be effective against some HPV-related diseases, showing great potential in the treatment of HPV-associated oral squamous cell carcinoma (HPV+ OSCC). However, the poor bioavailability, short half-lives, and stability issues of catechins hamper their clinical application. To overcome these shortcomings of catechins, we innovatively synthesised an injectable supramolecular hydrogel, namely catechin-phenylenebisboronic acid-isoguanosine (CPBisoG), with catechin (one of the simplest catechins) and isoguanosine (isoG), another natural product with self-assembly ability, via dynamic phenylborate diester bonds...
December 20, 2022: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/35770917/green-tea-polyphenols-cause-apoptosis-and-autophagy-in-hpv-16-subgene-immortalized-human-cervical-epithelial-cells-via-the-activation-of-the-nrf2-pathway
#3
JOURNAL ARTICLE
Yi Tang, Quan Chen, Jiaoquan Chen, Ziyin Mo, Huaping Li, Liqian Peng, Yanan Ke, Bihua Liang, Runxiang Li, Huilan Zhu
Infection with human papillomavirus (HPV) is relatively common and certain high-risk HPV strains can induce epithelial dysplasia, increasing the risk of cervical cancer. Green tea polyphenol (GTP) preparations exhibit diverse anti-inflammatory, antioxidative, and antitumor properties In Vitro and In Vivo. Topical GTP application has been recommended as a treatment for genital warts, but the effect of GTP treatment on HPV infection and HPV-associated cancer remains to be established. The present study aimed to explore the mechanism by which GTP affected HPV type 16 (HPV-16)-positive immortalized human cervical epithelial cells...
June 30, 2022: Nutrition and Cancer
https://read.qxmd.com/read/33920477/the-major-constituent-of-green-tea-epigallocatechin-3-gallate-egcg-inhibits-the-growth-of-hpv18-infected-keratinocytes-by-stimulating-proteasomal-turnover-of-the-e6-and-e7-oncoproteins
#4
JOURNAL ARTICLE
Jason K W Yap, Sean T Kehoe, Ciaran B J Woodman, Christopher W Dawson
Epigallocatechin-3-gallate (EGCG), the primary bioactive polyphenol in green tea, has been shown to inhibit the growth of human papilloma virus (HPV)-transformed keratinocytes. Here, we set out to examine the consequences of EGCG treatment on the growth of HPV18-immortalised foreskin keratinocytes (HFK-HPV18) and an authentic HPV18-positive vulvar intraepithelial neoplasia (VIN) clone, focusing on its ability to influence cell proliferation and differentiation and to impact on viral oncogene expression and virus replication...
April 11, 2021: Pathogens
https://read.qxmd.com/read/32498451/applications-of-a-standardized-green-tea-catechin-preparation-for-viral-warts-and-human-papilloma-virus-related-and-unrelated-cancers
#5
REVIEW
Noriyuki Miyoshi, Hiroki Tanabe, Takuji Suzuki, Koichi Saeki, Yukihiko Hara
Most cell-based and animal experiments have shown that green tea catechins (GTC) exhibit various health benefits. In human experimental and epidemiological studies, there are conflicting results, and more precise investigations are required. One of the most effective ways to prove beneficial health effects in humans might be clinical intervention studies. Polyphenon® E was developed as a standardized GTC preparation, which was approved by Food and Drug Administration of US in 2006 as a medication to treat genital warts (Veregen® or sinecatechins)...
June 2, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/32457393/structural-dynamic-studies-on-identification-of-egcg-analogues-for-the-inhibition-of-human-papillomavirus-e7
#6
JOURNAL ARTICLE
Murali Aarthy, Umesh Panwar, Sanjeev Kumar Singh
High risk human papillomaviruses are highly associated with the cervical carcinoma and the other genital tumors. Development of cervical cancer passes through the multistep process initiated from benign cyst to increasingly severe premalignant dysplastic lesions in an epithelium. Replication of this virus occurs in the fatal differentiating epithelium and involves in the activation of cellular DNA replication proteins. The oncoprotein E7 of human papillomavirus expressed in the lower epithelial layers constrains the cells into S-phase constructing an environment favorable for genome replication and cell proliferation...
May 26, 2020: Scientific Reports
https://read.qxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#7
REVIEW
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
June 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/29346317/liposomal-tricurin-a-synergistic-combination-of-curcumin-epicatechin-gallate-and-resveratrol-repolarizes-tumor-associated-microglia-macrophages-and-eliminates-glioblastoma-gbm-and-gbm-stem-cells
#8
JOURNAL ARTICLE
Sumit Mukherjee, Juliet N E Baidoo, Samay Sampat, Andrew Mancuso, Lovena David, Leah S Cohen, Shuiqin Zhou, Probal Banerjee
Glioblastoma (GBM) is a deadly brain tumor with a current mean survival of 12-15 months. Despite being a potent anti-cancer agent, the turmeric ingredient curcumin (C) has limited anti-tumor efficacy in vivo due to its low bioavailability. We have reported earlier a strategy involving the use two other polyphenols, epicatechin gallate (E) from green tea and resveratrol (R) from red grapes at a unique, synergistic molar ratio with C (C:E:R: 4:1:12.5, termed TriCurin) to achieve superior potency against HPV+ tumors than C alone at C:E:R (μM): 32:8:100 (termed 32 μM+ TriCurin)...
January 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/28977833/unique-synergistic-formulation-of-curcumin-epicatechin-gallate-and-resveratrol-tricurin-suppresses-hpv-e6-eliminates-hpv-cancer-cells-and-inhibits-tumor-progression
#9
JOURNAL ARTICLE
Sumit Mukherjee, Priya Ranjan Debata, Rahman Hussaini, Kaushiki Chatterjee, Juliet N E Baidoo, Samay Sampat, Anita Szerszen, Joseph P Navarra, Jimmie Fata, Elena Severinova, Probal Banerjee, Mario R Castellanos
Curcumin (from curry) (C) is highly potent against cervical cancer cells (CCC), but poor bioavailability has limited its clinical use. Similar natural polyphenols resveratrol (from grapes) (R), and epicatechin gallate (from green tea) (E) also display activity against CCC. By treating CCC (HeLa) with C, E, or R, or combinations of these compounds, we computed combination indices and observed a strong synergism among C, E, and R at the unique molar ratio 4:1:12.5. This combination, named as TriCurin, rapidly down regulated HPV18 E6 and NF-kB expression while concomitantly inducing the tumor suppressor protein p53 in HeLa cells...
September 22, 2017: Oncotarget
https://read.qxmd.com/read/28947951/tricurin-a-novel-formulation-of-curcumin-epicatechin-gallate-and-resveratrol-inhibits-the-tumorigenicity-of-human-papillomavirus-positive-head-and-neck-squamous-cell-carcinoma
#10
JOURNAL ARTICLE
Longzhu Piao, Sumit Mukherjee, Qing Chang, Xiujie Xie, Hong Li, Mario R Castellanos, Probal Banerjee, Hassan Iqbal, Ryan Ivancic, Xueqian Wang, Theodoros N Teknos, Quintin Pan
Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with about 600,000 new cases diagnosed in the last year. The incidence of human papillomavirus-positive head and neck squamous cell carcinoma (HPV-positive HNSCC) has rapidly increased over the past 30 years prompting the suggestion that an epidemic may be on the horizon. Therefore, there is a clinical need to develop alternate therapeutic strategies to manage the growing number of HPV-positive HNSCC patients. TriCurin is a composition of three food-derived polyphenols in unique stoichiometric proportions consisting of curcumin from the spice turmeric, resveratrol from red grapes, and epicatechin gallate from green tea...
September 1, 2017: Oncotarget
https://read.qxmd.com/read/28416754/unique-synergistic-formulation-of-curcumin-epicatechin-gallate-and-resveratrol-tricurin-suppresses-hpv-e6-eliminates-hpv-cancer-cells-and-inhibits-tumor-progression
#11
JOURNAL ARTICLE
Sumit Mukherjee, Priya Ranjan Debata, Rahman Hussaini, Kaushiki Chatterjee, Juliet N E Baidoo, Samay Sampat, Anita Szerszen, Joseph P Navarra, Jimmie Fata, Elena Severinova, Probal Banerjee, Mario R Castellanos
Curcumin (from curry) (C) is highly potent against cervical cancer cells (CCC), but poor bioavailability has limited its clinical use. Similar natural polyphenols resveratrol (from grapes) (R), and epicatechin gallate (from green tea) (E) also display activity against CCC. By treating CCC (HeLa) with C, E, or R, or combinations of these compounds, we computed combination indices and observed a strong synergism among C, E, and R at the unique molar ratio 4:1:12.5. This combination, named as TriCurin, rapidly down regulated HPV18 E6 and NF-kB expression while concomitantly inducing the tumor suppressor protein p53 in HeLa cells...
March 29, 2017: Oncotarget
https://read.qxmd.com/read/27437871/tricurin-a-novel-formulation-of-curcumin-epicatechin-gallate-and-resveratrol-inhibits-the-tumorigenicity-of-human-papillomavirus-positive-head-and-neck-squamous-cell-carcinoma
#12
Longzhu Piao, Sumit Mukherjee, Qing Chang, Xiujie Xie, Hong Li, Mario R Castellanos, Probal Banerjee, Hassan Iqbal, Ryan Ivancic, Xueqian Wang, Theodoros N Teknos, Quintin Pan
Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with about 600,000 new cases diagnosed in the last year. The incidence of human papillomavirus-positive head and neck squamous cell carcinoma (HPV-positive HNSCC) has rapidly increased over the past 30 years prompting the suggestion that an epidemic may be on the horizon. Therefore, there is a clinical need to develop alternate therapeutic strategies to manage the growing number of HPV-positive HNSCC patients. TriCurin is a composition of three food-derived polyphenols in unique stoichiometric proportions consisting of curcumin from the spice turmeric, resveratrol from red grapes, and epicatechin gallate from green tea...
July 16, 2016: Oncotarget
https://read.qxmd.com/read/25814698/immunomodulators-in-warts-unexplored-or-ineffective
#13
REVIEW
Surabhi Sinha, Vineet Relhan, Vijay K Garg
Cutaneous warts are known to be recurrent and often resistant to therapy. Resistant warts may reflect a localized or systemic cell mediated immune (CMI) deficiency to HPV. Many modalities of treatment are in use; most of the provider-administered therapies are destructive and cause scarring, such as cryotherapy, chemical cauterisation, curettage, electrodessication and laser removal. Most patient-applied agents like podophyllotoxin have the risk of application-site reactions and recurrence. Thus immunotherapy is a promising modality which could lead to resolution of warts without any physical changes or scarring and in addition would augment the host response against the causative agent, thereby leading to complete resolution and decreased recurrences...
March 2015: Indian Journal of Dermatology
https://read.qxmd.com/read/25807215/sinecatechins-10-ointment-a-green-tea-extract-for-the-treatment-of-external-genital-warts
#14
COMPARATIVE STUDY
Aditya K Gupta, Deanne Daigle
External genital warts (EGWs) resulting from the human papilloma virus (HPV) are a common sexually transmitted infection and cause significant impairments in patient quality of life and sexual well-being. Therapeutic options for EGWs can be provider-assisted, but many patients opt for treatment that can be applied at home. Sinecatechins 10% ointment is a new botanically based patient-administered therapy for EGWs. It is comprised of >85% catechins, green tea polyphenols that have been shown to possess antioxidant, antiproliferative, antiviral, and antitumor properties...
January 2015: Skin Therapy Letter
https://read.qxmd.com/read/25774455/expression-patterns-of-immune-associated-genes-in-external-genital-and-perianal-warts-treated-with-sinecatechins
#15
JOURNAL ARTICLE
Hung Q Doan, Harrison P Nguyen, Peter Rady, Stephen K Tyring
The role of human papillomavirus (HPV) in human disease includes external genital and perianal warts (EGW), with some HPV genotypes having oncogenic potential (i.e., HPV-16 and -18). While green-tea extracts have antitumor and antiproliferative effects in vitro, the mechanism of action of sinecatechins in the treatment of EGW is not well understood. To investigate the role of immune-regulated genes further, an open-label, single institution, prospective study was conducted enrolling patients with clinically diagnosed EGW...
May 2015: Viral Immunology
https://read.qxmd.com/read/24643181/genitoanal-human-papillomavirus-infection-and-associated-neoplasias
#16
JOURNAL ARTICLE
Gerd Gross
Human papillomavirus (HPV) infection is the most common sexually transmitted virus infection; about 40 out of 150 known HPV genotypes have been associated with genitoanal lesions in the female and male. They have been divided into low-risk (LR) and high-risk (HR) HPV types according to the association of each HPV genotype with genitoanal benign warts, genitoanal cancer and precursor lesions. For the most part, genitoanal HPV infection is equally common in men and in women. Genitoanal HPVs are predominantly transmitted by sexual intercourse...
2014: Current Problems in Dermatology
https://read.qxmd.com/read/24388920/results-of-a-phase-ii-randomized-double-blind-placebo-controlled-trial-of-polyphenon-e-in-women-with-persistent-high-risk-hpv-infection-and-low-grade-cervical-intraepithelial-neoplasia
#17
RANDOMIZED CONTROLLED TRIAL
Francisco A R Garcia, Terri Cornelison, Tomas Nuño, David L Greenspan, John W Byron, Chiu-Hsieh Hsu, David S Alberts, H-H Sherry Chow
OBJECTIVE: In vitro data and pilot data suggest that green tea catechins may possess chemopreventive activity for cervical cancer and precursor lesions. We conducted a randomized, double-blind, placebo-controlled trial of Polyphenon E (decaffeinated and enriched green tea catechin extract) in women with persistent human papillomavirus (HPV) infection and low-grade cervical intraepithelial neoplasia (CIN1) to evaluate the potential of Polyphenon E for cervical cancer prevention. METHODS: Ninety-eight eligible women were randomized to receive either Polyphenon E (containing 800 mg epigallocatechin gallate) or placebo once daily for 4 months...
February 2014: Gynecologic Oncology
https://read.qxmd.com/read/24011309/update-on-the-treatment-of-genital-warts
#18
REVIEW
Noah Scheinfeld
This review summarizes new treatments from the last seven years employed for the treatment of genital warts caused by human papillomavirus (HPV). Imquimod 3.75% is a new agent with fewer side effects and perhaps a better dosing schedule than imquimod 5%, but is not more effective. Sinecatechins/Polyphenon E 15%, a novel extract from green tea can be effective against genital warts but requires three times a day dosing and is not more effective than existing treatments; the treatment course is 12-16 weeks. Photodynamic therapy combined with other destructive modalities might increase the cure rate for genital warts...
June 15, 2013: Dermatology Online Journal
https://read.qxmd.com/read/23399786/naturopathic-management-of-females-with-cervical-atypia-a-delphi-process-to-explore-current-practice
#19
JOURNAL ARTICLE
Cynthia Ann Leaver, Claiborne Miller-Davis, Gwenyth R Wallen
BACKGROUND: Human papillomavirus is the most significant factor contributing to cervical cancer. Naturopathic doctors (NDs) implement an integrative approach to treat cervical atypia. This study explored practice consensus and variance among NDs. METHODS: A purposefully selected panel of six NDs participated in a modified Delphi study to validate practice. Three electronic web-based surveys were completed over nine months. RESULTS: Local and systemic treatments were included in all ND protocols...
2013: Integrative Medicine Insights
https://read.qxmd.com/read/23135094/green-tea-catechins-biologic-properties-proposed-mechanisms-of-action-and-clinical-implications
#20
REVIEW
Ted Rosen
Botanical products, including and especially green tea leaves, have a wide range of both reputed and demonstrated health benefits and have been used medicinally for thousands of years. This paper focuses on green tea catechins, principally reviewing their known biologic properties and potential mechanisms of action (MOAs). The primary objective is to discuss the proposed antiviral, antiproliferative, and immunostimulatory activity of catechins based on strong evidence from in vitro and in vivo studies conducted to date, including two preclinical in vitro studies with sinecatechins, a proprietary mixture of catechins...
November 2012: Journal of Drugs in Dermatology: JDD
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