keyword
MENU ▼
Read by QxMD icon Read
search

Tuberculosis and HIV Coinfection

keyword
https://www.readbyqxmd.com/read/29666702/an-evaluation-of-treatment-outcomes-in-a-cohort-of-clients-on-the-dots-strategy-2012-2016
#1
Ato Kwamena Tetteh, Edward Agyarko, Joseph Otchere, Langbong Bimi, Irene Ayi
We present, for the first time, an evaluation of treatment outcomes in a cohort at a TB referral centre in the Central Region of Ghana. Of the 213 clients placed on DOTS, 59.2% (126/213) were sputum smear-positive. An overall cure rate of 90.2% (51.6% cured + 37.6% completed) and a death rate of 8.5% (18/213) were estimated. Of the number of clients who died, 5.7% (12/213) were males ( χ 2 = 2.891, p = 0.699; LR = 3.004, p = 0.699). Deaths were only recorded among clients who were > 19 years old ( χ 2 = 40...
2018: Tuberculosis Research and Treatment
https://www.readbyqxmd.com/read/29652971/-factors-associated-to-survival-in-patients-with-hiv-tb-in-the-department-of-infectious-diseases-of-the-arzobispo-loayza-national-hospital-per%C3%A3%C2%BA-since-2004-to-2012
#2
Brenda Gamboa-Acuña, Rayza Guillén-Zambrano, Grecia Lizzetti-Mendoza, Alonso Soto, Aldo Lucchetti-Rodríguez
Background The main cause of death in HIV patients is tuberculosis (TB). However, few Latin American studies have evaluated the prognosis of patients with coinfection. Aim To determine the factors associated with survival in patients with HIV-TB coinfection treated at a Peruvian referral hospital. Methods A retrospective cohort study was performed based on clinical records of patients treated at the Department of Infectious Diseases in the Arzobispo Loayza National Hospital from 2004 to 2012. Survival was assessed using the Kaplan-Meier estimator and Cox Proportional Hazard Model...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29610143/characterization-of-the-antigenic-heterogeneity-of-lipoarabinomannan-the-major-surface-glycolipid-of-mycobacterium-tuberculosis-and-complexity-of-antibody-specificities-toward-this-antigen
#3
Alok Choudhary, Deendayal Patel, William Honnen, Zhong Lai, Raja Sekhar Prattipati, Ruixiang Blake Zheng, Ying-Chao Hsueh, Maria Laura Gennaro, Alfred Lardizabal, Blanca I Restrepo, Moncerrato Garcia-Viveros, Maju Joe, Yu Bai, Ke Shen, Kamar Sahloul, John S Spencer, Delphi Chatterjee, Tobias Broger, Todd L Lowary, Abraham Pinter
Lipoarabinomannan (LAM), the major antigenic glycolipid of Mycobacterium tuberculosis , is an important immunodiagnostic target for detecting tuberculosis (TB) infection in HIV-1-coinfected patients, and is believed to mediate a number of functions that promote infection and disease development. To probe the human humoral response against LAM during TB infection, several novel LAM-specific human mAbs were molecularly cloned from memory B cells isolated from infected patients and grown in vitro. The fine epitope specificities of these Abs, along with those of a panel of previously described murine and phage-derived LAM-specific mAbs, were mapped using binding assays against LAM Ags from several mycobacterial species and a panel of synthetic glycans and glycoconjugates that represented diverse carbohydrate structures present in LAM...
April 2, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29601253/the-current-status-challenges-and-future-developments-of-new-tuberculosis-vaccines
#4
Wenping Gong, Yan Liang, Xueqiong Wu
Mycobacterium tuberculosis complex causes tuberculosis (TB), one of the top 10 causes of death worldwide. TB results in more fatalities than multi-drug resistant (MDR) HIV strain related coinfection. Vaccines play a key role in the prevention and control of infectious diseases. Unfortunately, the only licensed preventive vaccine against TB, bacilli Calmette-Guérin (BCG), is ineffective for prevention of pulmonary TB in adults. Therefore, it is very important to develop novel vaccines for TB prevention and control...
March 30, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29581940/training-social-workers-to-enhance-patient-centered-care-for-drug-resistant-tb-hiv-in-south-africa
#5
J R Zelnick, B Seepamore, A Daftary, K R Amico, X Bhengu, G Friedland, N Padayatchi, K Naidoo, M R O'Donnell
KwaZulu-Natal, South Africa, is the epicenter of an epidemic of drug-resistant tuberculosis (DR-TB) and human immunodeficiency virus (HIV) co-infection, characterized by low rates of medication adherence and retention in care. Social workers may have a unique role to play in improving DR-TB-HIV outcomes. We designed, implemented and evaluated a model-based pilot training course on patient-centered care, treatment literacy in DR-TB and HIV coinfection, patient support group facilitation, and self-care. Ten social workers participated in a 1-day training course...
March 21, 2018: Public Health Action
https://www.readbyqxmd.com/read/29580884/mycobacterium-tuberculosis
#6
Anastasia Koch, Valerie Mizrahi
In this infographic, the genetics, phylogeny, physiology, and pathogenesis mechanisms of Mycobacterium tuberculosis are shown. Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), the leading cause of death due to a single infectious agent, claiming 1.7 million lives in 2016. Of the deaths attributable to TB in 2016, 22% occurred in people coinfected with HIV, and close to 5% of the 10.4 million incident cases of this disease were resistant to at least two of the first-line TB drugs. In this infographic, we describe the fundamental features of the genetics, phylogeny, and physiology of this member of the phylum Actinobacteria, which is associated increasingly with drug resistance mediated by mutations and rearrangements in its single, circular chromosome...
March 23, 2018: Trends in Microbiology
https://www.readbyqxmd.com/read/29570492/when-do-coinfections-matter
#7
Andrew J McArdle, Anna Turkova, Aubrey J Cunnington
PURPOSE OF REVIEW: Advances in diagnostic methods mean that coinfections are increasingly being detected in clinical practice, yet their significance is not always obvious. In parallel, basic science studies are increasingly investigating interactions between pathogens to try to explain real-life observations and elucidate biological mechanisms. RECENT FINDINGS: Coinfections may be insignificant, detrimental, or even beneficial, and these outcomes can occur through multiple levels of interactions which include modulation of the host response, altering the performance of diagnostic tests, and drug-drug interactions during treatment...
March 22, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29564278/thrombocytopenia-in-hiv-patients-coinfected-with-tuberculosis
#8
A S Sandhya, Brijesh Prajapat
Thrombocytopenia is one of the most common hematological manifestations seen in HIV patients with approximately 40% of the patients developing thrombocytopenia during their course of illness. Opportunistic infection like tuberculosis is a rare but curative cause of thrombocytopenia in these patients. Clinically, it is a challenge to determine the exact cause and decide the treatment of thrombocytopenia in these patients as both infections can lead to significant thrombocytopenia by varied mechanisms. The treatment options are limited by drug antitubercular treatment highly active antiretroviral therapy (ATT and HAART)-induced thrombocytopenia...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29545471/economic-burden-of-hiv-and-tb-hiv-coinfection-in-a-middle-income-country-a-costing-analysis-alongside-a-pragmatic-clinical-trial-in-brazil
#9
Noemia Teixeira de Siqueira-Filha, Maria de Fatima Militao de Albuquerque, Laura Cunha Rodrigues, Rosa Legood, Andreia Costa Santos
OBJECTIVE: The objective of this study was to measure the costs of people living with HIV (PLHIV) as well as active tuberculosis (TB/HIV), latent tuberculosis infection (LTBI/HIV) or without TB (HIV/AIDS). METHODS: We analysed the costs through the entire pathway of care during the prediagnosis and treatment periods from the Brazilian public health system perspective. We applied a combination of bottom-up and top-down approaches to capture and estimate direct medical and non-medical costs...
March 15, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29523319/major-genotype-families-and-epidemic-clones-of-mycobacterium-tuberculosis-in-omsk-region-western-siberia-russia-marked-by-a-high-burden-of-tuberculosis-hiv-coinfection
#10
Oksana Pasechnik, Anna Vyazovaya, Stanislav Vitriv, Marina Tatarintseva, Aleksey Blokh, Vladimir Stasenko, Igor Mokrousov
This population-based study characterized Mycobacterium tuberculosis isolates from HIV-positive and HIV-negative tuberculosis (TB) patients in the Omsk region in Western Siberia, Russia. We sought to gain insight into the major genotype families and epidemic and endemic clones of M. tuberculosis in the area with a high burden and adverse trend of TB/HIV coinfection. The study collection included M. tuberculosis isolates from 207 newly-diagnosed patients with pulmonary TB; 55 (26.5%) of patients were HIV-infected...
January 2018: Tuberculosis
https://www.readbyqxmd.com/read/29511357/childhood-tuberculosis-in-nigeria-disease-presentation-and-treatment-outcomes
#11
Chidubem L Ogbudebe, Victor Adepoju, Christy Ekerete-Udofia, Ebere Abu, Ginika Egesemba, Nkem Chukwueme, Mustapha Gidado
Objectives: Understanding the factors that influence tuberculosis (TB) treatment outcomes in children is key to designing interventions to address them. This study aimed to determine the case category distribution of childhood TB in Nigeria and assess which clinical and demographic factors are associated with different treatment outcomes in childhood TB. Materials and methods: This was a retrospective cohort study involving a review of medical records of children (0-14 years) with TB in 3 states in Nigeria in 2015...
2018: Health Services Insights
https://www.readbyqxmd.com/read/29507814/hiv-tb-coinfection-among-57-million-pregnant-women-obstetric-complications-alcohol-use-drug-abuse-and-depression
#12
Dorian Fernandez, Imoleayo Salami, Janelle Davis, Florence Mbah, Aisha Kazeem, Abreah Ash, Justin Babino, Laquiesha Carter, Jason L Salemi, Kiara K Spooner, Omonike A Olaleye, Hamisu M Salihu
Objective: HIV and tuberculosis represent diseases of major public health importance worldwide. Very little is known about HIV-TB coinfection among pregnant women, especially from industrialized settings. In this study, we examined the association between TB, HIV, and HIV-TB coinfection among pregnant mothers and obstetric complications, alcohol use, drug abuse, and depression. Method: We examined inpatient hospital discharges in the United States from January 1, 2002, through December 31, 2014...
2018: Journal of Pregnancy
https://www.readbyqxmd.com/read/29496619/the-association-between-arv-and-tb-drug-resistance-on-tb-treatment-outcome-among-kazakh-tb-hiv-patients
#13
Kathryn Mishkin, Kamiar Alaei, Elmira Alikeyeva, Christopher Paynter, Altyn Aringazina, Arash Alaei
INTRODUCTION: TB drug resistance poses a serious threat to the public health of Kazakhstan. This paper presents findings related to TB treatment outcome and drug resistant status among people coinfected with HIV and TB in Kazakhstan. METHODS: Cohort study using data were provided by the Kazakhstan Ministry of Health's National Tuberculosis Program for 2014 and 2015. Chi-square and logistical regression were performed to understand factors associated with drug resistant TB status and TB treatment outcome...
February 26, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29493093/highlights-of-the-2017-european-aids-clinical-society-eacs-guidelines-for-the-treatment-of-adult-hiv-positive-persons-version-9-0
#14
L Ryom, C Boesecke, M Bracchi, J Ambrosioni, A Pozniak, J Arribas, G Behrens, Pgm Mallon, M Puoti, A Rauch, J M Miro, O Kirk, C Marzolini, J D Lundgren, M Battegay
BACKGROUND: The European AIDS Clinical Society (EACS) Guidelines have since 2005 provided multidisciplinary recommendations for the care of HIV-positive persons in geographically diverse areas. GUIDELINE HIGHLIGHTS: Major revisions have been made in all sections of the 2017 Guidelines: antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Newly added are also a summary of the main changes made, and direct video links to the EACS online course on HIV Management...
March 1, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29490165/the-immune-response-to-mycobacterium-tuberculosis-in-hiv-1-coinfected-persons
#15
Hanif Esmail, Catherine Riou, Elsa du Bruyn, Rachel Pei-Jen Lai, Yolande X R Harley, Graeme Meintjes, Katalin A Wilkinson, Robert J Wilkinson
Globally, about 36.7 million people were living with HIV infection at the end of 2015. The most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis-389,000 deaths per annum are attributable to HIV tuberculosis, 75% of those occurring in Africa. HIV-1 infection increases the risk of tuberculosis by a factor of up to 26 and alters its clinical presentation, complicates diagnosis and treatment, and worsens outcome. Although HIV-1-induced depletion of CD4+ T cells underlies all these effects, more widespread immune deficits also contribute to susceptibility and pathogenesis...
February 28, 2018: Annual Review of Immunology
https://www.readbyqxmd.com/read/29447374/spectrum-of-pediatric-tuberculosis-in-a-tertiary-care-setting-in-south-india
#16
Betsy Rebecca, Anila Chacko, Valsan Verghese, Winsley Rose
Background: Pediatric tuberculosis (TB) is often underdiagnosed with poor estimate of its true burden. Availability of Xpert MTB/RIF assay enhances diagnostic capacity of pediatric TB. Methods: A 3-year retrospective review of hospital records was done for all children diagnosed with confirmed and unconfirmed TB. Comparison was made between intrathoracic, single-site extrathoracic and disseminated TB. Results: In total, 274 children had TB with 130 (47...
February 13, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29432596/high-turnover-of-tissue-macrophages-contributes-to-tuberculosis-reactivation-in-simian-immunodeficiency-virus-infected-rhesus-macaques
#17
Marcelo J Kuroda, Chie Sugimoto, Yanhui Cai, Kristen M Merino, Smriti Mehra, Mariluz Araínga, Chad J Roy, Cecily C Midkiff, Xavier Alvarez, Elizabeth S Didier, Deepak Kaushal
Background: Tuberculosis (TB) and human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) profoundly affect the immune system and synergistically accelerate disease progression. It is believed that CD4+ T-cell depletion by HIV is the major cause of immunodeficiency and reactivation of latent TB. Previous studies demonstrated that blood monocyte turnover concurrent with tissue macrophage death from virus infection better predicted AIDS onset than CD4+ T-cell depletion in macaques infected with simian immunodeficiency virus (SIV)...
February 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29432590/mycobacterium-tuberculosis-and-hiv-coinfection-brings-fire-and-fury-to-macrophages
#18
Nargis Khan, Maziar Divangahi
No abstract text is available yet for this article.
February 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29362063/management-of-coinfections-in-patients-with-human-immunodeficiency-virus
#19
REVIEW
Sabra S Custer
In addition to chronic use of antiretrovirals to maintain suppression of human immunodeficiency virus (HIV), many persons living with HIV are coinfected with tuberculosis, hepatitis B, or hepatitis C. These coinfections can be successfully treated or managed alongside HIV infection. Clinicians should follow practice guidelines to appropriately screen patients with HIV for these coinfections and initiate treatment when necessary. The most significant concern when treating any of these coinfections is to avoid drug-drug interactions with the patient's antiretrovirals...
March 2018: Nursing Clinics of North America
https://www.readbyqxmd.com/read/29339504/complement-pathway-gene-activation-and-rising-circulating-immune-complexes-characterize-early-disease-in-hiv-associated-tuberculosis
#20
Hanif Esmail, Rachel P Lai, Maia Lesosky, Katalin A Wilkinson, Christine M Graham, Stuart Horswell, Anna K Coussens, Clifton E Barry, Anne O'Garra, Robert J Wilkinson
The transition between latent and active tuberculosis (TB) occurs before symptom onset. Better understanding of the early events in subclinical disease will facilitate the development of diagnostics and interventions that improve TB control. This is particularly relevant in the context of HIV-1 coinfection where progression of TB is more likely. In a recent study using [18 F]-fluoro-2-deoxy-d-glucose positron emission/computed tomography (FDG-PET/CT) on 35 asymptomatic, HIV-1-infected adults, we identified 10 participants with radiographic evidence of subclinical disease, significantly more likely to progress than the 25 participants without...
January 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
4847
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"