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https://www.readbyqxmd.com/read/29141219/preventive-inhibition-of-liver-tumorigenesis-by-systemic-activation-of-innate-immune-functions
#1
Jin Lee, Rui Liao, Gaowei Wang, Bi-Huei Yang, Xiaolin Luo, Nissi M Varki, Shuang-Jian Qiu, Bing Ren, Wenxian Fu, Gen-Sheng Feng
Liver cancer has become the second most deadly malignant disease, with no efficient targeted or immune therapeutic agents available yet. While dissecting the roles of cytoplasmic signaling molecules in hepatocarcinogenesis using an inducible mouse gene targeting system, Mx1-cre, we identified a potent liver tumor-inhibitory effect of synthetic double-stranded RNA (dsRNA), polyinosinic-polycytidylic acid (pIC), an inducer of the Mx1-cre system. Injection of pIC at the pre-cancer stage robustly suppressed liver tumorigenesis either induced by chemical carcinogens or by Pten loss and associated hepatosteatosis...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29031897/smart-electrical-bi-layers-lipopeptides-novel-peptidic-chains-like-zigzag-map-esterified-with-phospho-glyceride-as-mono-layer-moieties-capable-in-forming-a-meso-sphere-envelop-with-scaffold-ability-to-cellular-impurities
#2
REVIEW
Sami Saadi, Nazamid Saari, Abdulkarim Sabo Mohammed, Hasanah Mohd Ghazali, Farooq Anwar
Cell impurities are an emerging nucleating molecular barriers having the capability in disordering the metabolic chain reactions of proteolysis, glycolysis and lipolysis. Their massive effects induced by copolymer crystal growth in compaction with metal and mineral transients are extended as well as in damaging DNA and mRNA structure motif and other molecular assembly e.g. histones structure unites. Their polycrystalline packing modes, polydispersity and their tendency to surface and interface adhesion prompted us in structuring scaffold biomaterials enriched with biopeptides, layered by phospho-glycerides ester-forms...
October 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28970571/local-disorder-in-na0-5bi0-5tio3-piezoceramic-determined-by-3d-electron-diffuse-scattering
#3
Alexandra Neagu, Cheuk-Wai Tai
Local structural distortions in Na0.5Bi0.5TiO3-based solid solutions have been proved to play a crucial role in understanding and tuning their enhanced piezoelectric properties near the morphotropic phase boundary. In this work all local structural disorders in a lead-free ternary system, namely 85%Na0.5Bi0.5TiO3-10%Bi0.5K0.5TiO3-5%BaTiO3, were mapped in reciprocal space by 3D electron diffraction. Furthermore, a comprehensive model of the local disorder was developed by analysing the intensity and morphology of the observed weak diffuse scattering...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28334810/bimodal-regulation-of-dishevelled-function-by-vangl2-during-morphogenesis
#4
Hwa-Seon Seo, Raymond Habas, Chenbei Chang, Jianbo Wang
Convergent extension (CE) is a fundamental morphogenetic mechanism that underlies numerous processes in vertebrate development, and its disruption can lead to human congenital disorders such as neural tube closure defects. The dynamic, oriented cell intercalation during CE is regulated by a group of core proteins identified originally in flies to coordinate epithelial planar cell polarity (PCP). The existing model explains how core PCP proteins, including Van Gogh (Vang) and Dishevelled (Dvl), segregate into distinct complexes on opposing cell cortex to coordinate polarity among static epithelial cells...
June 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/27709267/timap-repression-by-tgf%C3%AE-and-hdac3-associated-smad-signaling-regulates-macrophage-m2-phenotypic-phagocytosis
#5
Jun Yang, Shasha Yin, Fangfang Bi, Lin Liu, Tian Qin, Hongwei Wang, Wangsen Cao
TIMAP (TGFβ-inhibited membrane-associated protein) is an endothelium-enriched TGFβ downstream protein and structurally belongs to the targeting subunit of myosin phosphatase; however, the mechanism of TGFβ repressing TIMAP and its functional relevance to TGFβ bioactivity remain largely unknown. Here, we report that TIMAP is reduced in TGFβ-elevated mouse fibrotic kidney and highly expressed in macrophages. TGFβ repression of TIMAP is associated with HDAC3 upregulation and its recruitment by Smad2/3 at the Smad binding element on TIMAP promoter, whereas specific HDAC3 inhibition reversed the TIMAP repression, suggesting that TGFβ transcriptionally downregulates TIMAP through HDAC3-associated Smad signaling...
March 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/27661388/the-effect-of-chemical-variations-on-the-structural-polarity-of-relaxor-ferroelectrics-studied-by-resonance-raman-spectroscopy
#6
A Rohrbeck, G de la Flor, M I Aroyo, M Gospodinov, U Bismayer, B Mihailova
Resonance Raman spectroscopy was applied to doped PbSc0.5Ta0.5O3 and PbSc0.5Nb0.5O3 relaxor ferroelectrics, to better understand the effect of composition disorder on the mesoscopic-scale polar order in complex perovskite-type (ABO3) ferroelectrics. The excitation photon energy used was 3.8 eV, which is slightly above the energy gap and corresponds to the maximum of the optical dielectric permittivity. Group-theory analysis reveals that the resonance Raman scattering (RRS) observed under these conditions is allowed only in polar crystal classes...
November 30, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27626290/polar-nature-of-ch3nh3-3bi2i9-perovskite-like-hybrids
#7
Machteld E Kamminga, Alessandro Stroppa, Silvia Picozzi, Mikhail Chislov, Irina A Zvereva, Jacob Baas, Auke Meetsma, Graeme R Blake, Thomas T M Palstra
High-quality single crystals of perovskite-like (CH3NH3)3Bi2I9 hybrids have been synthesized, using a layered-solution crystal-growth technique. The large dielectric constant is strongly affected by the polar ordering of its constituents. Progressive dipolar ordering of the methylammonium cation upon cooling below 300 K gradually converts the hexagonal structure (space group P63/mmc) into a monoclinic phase (C2/c) at 160 K. A well-pronounced, ferrielectric phase transition at 143 K is governed by in-plane ordering of the bismuth lone pair that breaks inversion symmetry and results in a polar phase (space group P21)...
January 3, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/27165848/novel-optically-active-lead-free-relaxor-ferroelectric-ba0-6bi0-2li0-2-tio3
#8
Hitesh Borkar, Vaibhav Rao, Soma Dutta, Arun Barvat, Prabir Pal, M Tomar, Vinay Gupta, J F Scott, Ashok Kumar
We discovered a near-room-temperature lead-free relaxor-ferroelectric (Ba0.6Bi0.2Li0.2)TiO3 (BBLT) having A-site compositionally disordered ABO3 perovskite structure. Microstructure-property relations revealed that the chemical inhomogeneities and development of local polar nano-regions (PNRs) are responsible for dielectric dispersion as a function of probe frequencies and temperatures. Rietveld analysis indicates mixed crystal structure with 80% tetragonal structure (space group P4mm) and 20% orthorhombic structure (space group Amm2), which is confirmed by the high resolution transmission electron diffraction (HRTEM)...
July 6, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/26297858/absolute-polarity-determination-of-teeth-cementum-by-phase-sensitive-second-harmonic-generation-microscopy
#9
Hanane Aboulfadl, Jürg Hulliger
The absolute sign of local polarity in relation to the biological growth direction has been investigated for teeth cementum using phase sensitive second harmonic generation microscopy (PS-SHGM) and a crystal of 2-cyclooctylamino-5-nitropyridine (COANP) as a nonlinear optic (NLO) reference material. A second harmonic generation (SHG) response was found in two directions of cementum: radial (acellular extrinsic fibers that are oriented more or less perpendicular to the root surface) and circumferential (cellular intrinsic fibers that are oriented more or less parallel to the surface)...
October 2015: Journal of Structural Biology
https://www.readbyqxmd.com/read/26239525/origin-of-anomalous-giant-dielectric-performance-in-novel-perovskite-bi-0-5-x-laxna-0-5-x-lixti-1-y-myo3-m-mg2-ga3
#10
Xiao Liu, Huiqing Fan, Jing Shi, Qiang Li
Dielectric properties and dielectric relaxation behaviors of A/B sites co-substituted Bi0.5Na0.5TiO3 perovskite-type ferroelectrics are reported. The Bi(0.5-x)LaxNa(0.5-x)LixTi(1-y)MyO3 (M = Mg(2+), Ga(3+)) exhibits anomalous giant dielectric permittivity (ε') of ~10(5) under a heterogeneous constitution with easily discernible grain and grain boundary conductivity. The lone pairs substitution theory as well as extrinsic disorders are used to clarify the significant structural evolution and the origin of the dielectric performance...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26025403/oligodendrocyte-progenitor-cells-differentiation-of-nuclear-transferred-mouse-embryonic-stem-cells
#11
M Salehi, A Ardeshirylajimi, M Mossahebi-Mohammadi, Z Kondori, M Jorjani
Central nervous system (CNS) injuries cause to variable disorders in people around the world without any decisive treatment. Use of embryonic stem cells (ESCs) would be helpful in repairing of neural system damages. Somatic cell nuclear transfer (SCNT) is a way for implanting ESCs with lowest possible rejection. In the present study, mouse nuclear transfers ESCs (ntESCs) ability in differentiation to oligodendrocyte progenitor cells (OPCs) was investigated by morphological study, RT—PCR and flow cytometry analysis...
2015: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/24967993/structure-property-relationships-of-novel-microwave-dielectric-ceramics-with-low-sintering-temperatures-na-0-5x-bi-0-5x-ca-1-x-moo-4
#12
Jing Guo, Di Zhou, Yong Li, Tao Shao, Ze-Ming Qi, Biao-Bing Jin, Hong Wang
A novel series of microwave dielectric ceramics (Na0.5xBi0.5xCa1-x)MoO4 (0 ≤ x ≤ 0.6) was synthesized by the solid state reaction method. The crystal structures, microstructures, dielectric responses, and vibrational properties were investigated using X-ray diffraction, scanning electron microscopy, a microwave network analyzer, and terahertz, Raman and infrared spectroscopies. All the samples could be sintered well below 850 °C and a scheelite solid solution could be formed without any secondary phase...
August 21, 2014: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/24475060/the-real-world-mental-health-needs-of-heart-failure-patients-are-not-reflected-by-the-depression-randomized-controlled-trial-evidence
#13
Phillip J Tully, Gary Wittert, Terina Selkow, Harald Baumeister
INTRODUCTION: International depression screening guidelines in heart failure (HF) are partly based on depression treatment efficacy from randomized controlled trials (RCTs). Our aim was to test the external validity of depression RCT criteria in a sample of real-world HF patients. METHODS: HF patients admitted to 3 hospitals in South Australia were referred to a HF psychologist if not already receiving current psychiatric management by psychologist or psychiatrist elsewhere...
2014: PloS One
https://www.readbyqxmd.com/read/23544846/optoelectronic-and-ferroelectric-properties-of-cerium-doped-na-0-5-bi-0-5-ti-0-99-fe-0-01-o3-nanocrystalline-films-on-111-pt-tio2-sio2-si-a-composition-dependent-study
#14
Si Zhang, Meijie Han, Jinzhong Zhang, Yawei Li, Zhigao Hu, Junhao Chu
The optical and ferroelectric properties of (Na0.5Bi0.5)1-xCex(Ti0.99Fe0.01)O3 (NBCTFx; 0 ≤ x ≤ 0.10) nanocrystalline films deposited on platinized silicon (Pt/TiO2/SiO2/Si) substrates using a sol-gel method were investigated. The microstructure, surface, and cross-sectional morphology and compositions of the films were analyzed by X-ray diffraction, scanning electron microscopy, and X-ray photoelectron spectroscopy, respectively. The X-ray diffraction patterns indicate that all films are polycrystalline and show the single perovskite structure...
April 24, 2013: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/23160112/-long-term-treatment-of-bipolar-disorder-how-should-we-use-lithium-salts
#15
COMPARATIVE STUDY
Claudia Del Grande, Matteo Muti, Laura Musetti, Irene Pergentini, Martina Corsi, Milo Turri, Ilaria Soldani, Giovanni Umberto Corsini, Liliana Dell'Osso
UNLABELLED: Despite the great quantity of evidence supporting the efficacy of lithium in the maintenance treatment of bipolar disorder (BD), its use has often been limited because of issues about the management of this compound. W aimed to evaluate the use of lithium in common clinical practice and to identify possible relationships between the trend over time of serum lithium levels and clinical course of the illness. METHODS: 98 patients with bipolar I and bipolar II disorder (DSM-IV-TR) on maintenance treatment with lithium salts were recruited and followed up in a naturalistic trial at the Day Hospital of Psychiatric Clinic of Pisa...
November 2012: Rivista di Psichiatria
https://www.readbyqxmd.com/read/22427713/open-ended-and-open-door-treatment-groups-for-young-people-with-mental-illness
#16
Rachel Miller, Susan E Mason
The concept of open-ended groups is expanded to include an open-door model (OEOD) wherein members with severe mental illnesses, including schizophrenia disorders and bi-polar, can join, leave, and re-enter groups as their life circumstances dictate their availability and willingness for treatment. This model is grounded on the work of Schopler and Galinsky's (1984/2006) and Galinsky and Schopler's (1989) theses on the value and processes of open-ended groups and includes perspectives on mutual aid and group development...
2012: Social Work with Groups
https://www.readbyqxmd.com/read/22356424/local-structure-of-a-pure-bi-a-site-polar-perovskite-revealed-by-pair-distribution-function-analysis-and-reverse-monte-carlo-modeling-correlated-off-axis-displacements-in-a-rhombohedral-material
#17
Samantha Y Chong, Robert J Szczecinski, Craig A Bridges, Matthew G Tucker, John B Claridge, Matthew J Rosseinsky
Perovskite oxides with Bi(3+) on the A site are of interest as candidate replacements for lead-based piezoelectric ceramics. Current understanding of the chemical factors permitting the synthesis of ambient-pressure-stable perovskite oxides with Bi(3+) on the A site is limited to information derived from average structures. The local structure of the lead-free ferroelectric perovskite Bi(Ti(3/8)Fe(2/8)Mg(3/8))O(3) is studied by reverse Monte Carlo (RMC) modeling of neutron scattering data. The resultant model is consistent with the structure derived from diffraction but reveals key extra structural features due to correlated local displacements that are inaccessible from the average unit cell...
April 4, 2012: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/22111122/-advanced-imaging-methods-as-a-basis-for-more-reliable-classification-and-better-treatment-for-patients-with-depressive-symptoms-an-example-for-conceptual-change-in-the-psychiatric-diagnostic-method
#18
EDITORIAL
Tali Vishne
The current editorial study focuses on the idea of using advanced imaging methods in order to better classify and treat patients with depression and other psychiatric illnesses. The editorial is based on the review of Heymann and Bonne, published in this issue of the journal, showing differences between bi-polar and uni-polar depression using functional neuroimaging methods. This example, although not applicable yet in clinical practice, is the basis for future advances in psychiatric classification, together with clinical subtyping, and more biological markers, including genetic profiling...
October 2011: Harefuah
https://www.readbyqxmd.com/read/22049111/magnetic-and-electronic-properties-of-bi-0-75-ca-0-25-mno-3
#19
J L García-Muñoz, C Frontera, P Beran, N Bellido, J S Lord, C Ritter, I Margiolaki
The magnetic, structural and electronic properties of Bi(0.75)Ca(0.25)MnO(3) have been investigated in comparison with those of Bi(0.75)Sr(0.25)MnO(3). Magnetometry, diffraction and muon spin relaxation (μSR) data confirm different structural, magnetic and electronic transitions in the two compounds. The anisotropic changes of cell parameters across the structural transition in Bi(0.75)Ca(0.25)MnO(3) (275 K) differ markedly from the lattice anomalies in Bi(0.75)Sr(0.25)MnO(3) (600 K) and also from those in Bi(0...
October 10, 2007: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/21690933/crystal-structure-and-relaxor-type-transition-in-srbi-2-ta-2-o-9-doped-with-praseodymium
#20
J Mata, A Durán, E Martínez, R Escamilla, J Heiras, J M Siqueiros
The effects of Pr substitution in the structure and ferroelectric response for the Sr(1-x)Pr(x)Bi(2)Ta(2)O(9) (SBT-Pr) compound have been studied. Rietveld refinement of the x-ray diffraction patterns indicates that the Pr ion progressively replaces the Sr site in the A 2(1)am space group structure. The solubility of Pr in solid solution is around 15%. The replacement induces a change in the crystal structure and, as a consequence, the dielectric properties are affected. The ferroelectric transition at T(m)∼558 K is shifted to lower temperatures, T(m)∼413 K for x = 0...
November 22, 2006: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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