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imaging in kawasaki disease

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https://www.readbyqxmd.com/read/29920397/unusual-clinical-sequalae-of-kawasaki-disease-symptomatic-extracranial-internal-carotid-stenosis-in-young-adult-a-case-report
#1
Shigeomi Yokoya, Aiko Tamura, Akihiko Hino, Masamichi Bamba, Toshikazu Kato, Hidesato Takezawa, Yukihiro Goto, Hideki Oka, Akihiro Fujii
BACKGROUND: Kawasaki disease (KD) is an acute systemic vasculitis that primarily affects the coronary artery, but does not commonly affect the carotid artery. Cerebral infarction (CI) with internal carotid artery stenosis (ICS) in patients with KD had never been reported. We report a patient with CI as a remote phase complication of KD. CASE PRESENTATION: A 32-year-old man presented with impaired consciousness. Magnetic resonance imaging scan (MRI) and digital subtraction angiogram (DSA) confirmed CI and ICS...
June 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29913529/a-pilot-study-evaluating-cerebral-vasculitis-in-kawasaki-s-disease
#2
Jung Sook Yeom, Young Hye Cho, Chung Mo Koo, Jin Su Jun, Ji Sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Hyang-Ok Woo, Hee-Shang Youn
Cerebral vasculitis is thought to be a possible underlying mechanism of severe neurological complications of Kawasaki's disease (KD), such as cerebral infarct or aneurysm rupture. To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD ( n  = 7) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [ n  = 5], enteroviral meningitis [ n  = 10], nonspecific viral illness without central nervous system involvement [ n  = 10])...
June 18, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29874997/pathological-roles-of-iron-in-cardiovascular-disease
#3
Motoi Kobayashi, Tomohiro Suhara, Yuichi Baba, Nicholas K Kawasaki, Jason K Higa, Takashi Matsui
Iron is an essential mineral required for a variety of vital biological functions. Despite being vital for life, iron also has potentially toxic aspects. Iron has been investigated as a risk factor for coronary artery disease (CAD), however iron's toxicity in CAD patients still remains controversial. One possible mechanism behind the toxicity of iron is "ferroptosis", a newly described form of iron-dependent cell death. Ferroptosis is an iron-dependent form of regulated cell death that is distinct from apoptosis, necroptosis, and other types of cell death...
June 4, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29778491/-national-consensus-on-the-cardiological-treatment-and-follow-up-of-kawasaki-disease
#4
Ana Barrios Tascón, Fernando Centeno Malfaz, Henar Rojo Sombrero, Elisa Fernández-Cooke, Judith Sánchez-Manubens, Javier Pérez-Lescure Picarzo
Kawasaki disease is a self-limiting acute vasculitis that affects small and medium-sized vessels, and is the most common cause of acquired heart disease in children in our environment. Up to 25% of untreated patients develop coronary aneurysms. It is suspected that an infectious agent may be the trigger of the disease, but the causative agent is still unknown. Based on the previous evidence, recommendations are proposed for the diagnosis, treatment of acute disease, and the long-term management of these patients, in order to unify criteria...
May 16, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29772369/sciatic-neuralgia-caused-by-may-thurner-syndrome-case-report
#5
Kazuaki Yamamoto, Gakuji Gondo, Hidemitsu Ogino, Tsuyoshi Watanabe, Masahiko Tanaka, Satoshi Tanaka, Taisuke Kawasaki
BACKGROUND: Sciatic neuralgia (SN) is a type of pain commonly associated with lumbosacral radiculopathy. May-Thurner syndrome (MTS) is a disease characterized by venous congestion in the left common iliac vein (LCIV) due to right common iliac artery compression. In this report, the authors describe a case of MTS with SN as the first presenting symptom. CASE DESCRIPTION: A 53-year-old man gradually developed left SN; however, radiological examination showed no causal findings...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29707843/children-with-kawasaki-disease-present-elevated-stiffness-of-great-arteries-phase-contrast-mri-study
#6
Michal Schäfer, Uyen Truong, D Dunbar Ivy, Brian Fonseca, Ladonna Malone, Michael DiMaria, Alex J Barker, Daniel Vargas, Kendall S Hunter, Pei-Ni Jone, Lorna P Browne
BACKGROUND: Patients with diagnosed Kawasaki disease (KD) are known to develop extracardiac vascular lesions and are prone to accelerated stiffening of medium-size arteries. PURPOSE: To noninvasively evaluate great vessel (central aorta and main pulmonary artery (MPA)) stiffness using phase-contrast MRI (PC-MRI). STUDY TYPE: Retrospective review. SUBJECTS: Thirty-three patients with previously diagnosed KD and 15 control subjects underwent PC-MRI evaluation...
April 29, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29564349/computed-tomography-coronary-angiography-is-the-way-forward-for-evaluation-of-children-with-kawasaki-disease
#7
REVIEW
Manphool Singhal, Pankaj Gupta, Surjit Singh, Niranjan Khandelwal
Kawasaki disease (KD) is an acute idiopathic vasculitis affecting infants and children. Coronary artery abnormalities and myocarditis are the major cardiovascular complications of KD. Coronary artery abnormalities develop in 15-25% of untreated KD. Two-dimensional transthoracic echocardiography has hitherto been considered the modality of choice for evaluation of children with KD. There are, however, several limitations inherent to echocardiography - including limited evaluation of distal vessels, left circumflex artery and poor acoustic window in growing children...
October 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29564347/aneurysmal-coronary-artery-disease-an-overview
#8
REVIEW
Mohamed S ElGuindy, Ahmed M ElGuindy
Aneurysmal coronary artery disease (ACAD) comprises both coronary artery aneurysms (CAA) and coronary artery ectasia (CAE). The reported prevalence of ACAD varies widely from 0.2 to 10%, with male predominance and a predilection for the right coronary artery (RCA). Atherosclerosis is the commonest cause of ACAD in adults, while Kawasaki disease is the commonest cause in children and adolescents, as well as in the Far East. Most patients are asymptomatic, but when symptoms do exist, they are usually related to myocardial ischemia...
October 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29564343/remote-sensing-observation-of-annual-dust-cycles-and-possible-causality-of-kawasaki-disease-outbreaks-in-japan
#9
Hesham El-Askary, Nick LaHaye, Erik Linstead, William A Sprigg, Magdi Yacoub
Kawasaki disease (KD) is a rare vascular disease that, if left untreated, can result in irreparable cardiac damage in children. While the symptoms of KD are well-known, as are best practices for treatment, the etiology of the disease and the factors contributing to KD outbreaks remain puzzling to both medical practitioners and scientists alike. Recently, a fungus known as Candida, originating in the farmlands of China, has been blamed for outbreaks in China and Japan, with the hypothesis that it can be transported over long ranges via different wind mechanisms...
October 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29540277/stent-less-percutaneous-coronary-intervention-using-rotational-atherectomy-and-drug-coated-balloon-a-case-series-and-a-mini-review
#10
REVIEW
Jun Shiraishi, Nariko Koshi, Yuki Matsubara, Tetsuro Nishimura, Akira Shikuma, Keisuke Shoji, Daisuke Ito, Masayoshi Kimura, Eigo Kishita, Yusuke Nakagawa, Masayuki Hyogo, Takahisa Sawada
BACKGROUND: Experiences of rotational atherectomy (RA) followed by drug-coated balloon (DCB) dilation alone (RA/DCB) for de novo coronary artery lesion have been limited. CASE SERIES: Case 1 (65 year-old male) with silent myocardial ischemia and hemodialysis had old anterior myocardial infarction and intact LM/LCx, and underwent RA/DCB against a diffuse calcified lesion in the proximal LAD and a tandem lesion in the proximal RCA. Case 2 (88 year-old female) with post-infarction unstable angina had severe thrombocytopenia and anemia due to myelodysplastic syndrome (platelet 6000/μL, hemoglobin 8...
February 12, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29532436/serial-evaluation-of-myocardial-function-using-the-myocardial-performance-index-in-kawasaki-disease
#11
Eun Song Song, Somy Yoon, Joo Hyun Cho, Eun Mi Yang, Hwa Jin Cho, Young Youn Choi, Jae Sook Ma, Gwang Hyeon Eom, Young Kuk Cho
BACKGROUND: Kawasaki disease (KD) is known as systemic vasculitis, and more than half of the patients with KD have myocarditis, which can induce ventricular dysfunction. In this study, we evaluate left ventricular (LV) dysfunction in patients with KD based on the myocardial performance index (MPI) using pulse Doppler (PD) and tissue Doppler imaging (TDI), from the acute to convalescent phases. METHODS: We retrospectively studied 89 children diagnosed with KD from January 2010 to August 2012...
March 12, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29514171/optical-coherence-tomography-verified-morphological-correlates-of-high-intensity-coronary-plaques-on-non-contrast-t1-weighted-magnetic-resonance-imaging-in-patients-with-stable-coronary-artery-disease
#12
Tomoaki Kanaya, Teruo Noguchi, Fumiyuki Otsuka, Yasuhide Asaumi, Yu Kataoka, Yoshiaki Morita, Hiroyuki Miura, Kazuhiro Nakao, Masashi Fujino, Tomohiro Kawasaki, Kunihiro Nishimura, Teruo Inoue, Jagat Narula, Satoshi Yasuda
Aims: Coronary high-intensity plaques (HIPs) with a high plaque-to-myocardial signal intensity ratio (PMR) on non-contrast T1-weighted imaging in patients with stable coronary artery disease (CAD) are associated with future coronary events. To characterize the morphological substrate of HIP, we performed a correlative optical coherence tomography (OCT) study. Methods and results: We examined 137 lesions in 105 patients with stable angina pectoris or silent myocardial ischaemia scheduled for percutaneous coronary intervention (PCI) using a 3 T magnetic resonance scanner...
March 5, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29488043/evaluation-of-kawasaki-s-disease-associated-coronary-artery-aneurysms-with-3d-ct-cinematic-rendering
#13
Steven P Rowe, Stefan L Zimmerman, Pamela T Johnson, Elliot K Fishman
Kawasaki's disease (KD) is a vasculitis that predominantly affects children and can lead to the development of coronary artery aneurysms. These aneurysms can subsequently thrombose and occlude, which may lead to chest pain and other signs and symptoms of acute coronary syndrome in young patients. Coronary CT angiography, including 3D visualization techniques, is a common modality used in the follow-up of KD patients. In this series of three patients, we present the typical coronary artery imaging findings that can appear in these patients, with an emphasis on the use of the novel 3D technique of cinematic rendering (CR)...
February 27, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29426687/coronary-manifestations-of-kawasaki-disease-in-computed-tomography-coronary-angiography
#14
Yong Geng Goh, Ching Ching Ong, Grace Tan, Chong Ri Liang, Sanah Merchant Soomar, Chee Wen Terence Lim, Swee Chye Quek, Li San Lynette Teo
Coronary arteritis in Kawasaki disease can lead to serious complications such myocardial infarction and sudden death. The identification of coronary manifestations with a method that is minimally invasive and of low radiation exposure is therefore important in paediatric patients with Kawasaki disease. Coronary CT angiography can be an attractive alternative to invasive coronary angiography. This paper describes imaging techniques for coronary CT angiography in pediatric patients and demonstrates the spectrum of cardiovascular manifestations in patients with Kawasaki disease...
December 11, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29350882/cardiac-function-on-3-d-speckle-tracking-imaging-and-cytokines-in-kawasaki-disease
#15
Masataka Kato, Mamoru Ayusawa, Hirofumi Watanabe, Akiko Komori, Yuriko Abe, Takahiro Nakamura, Hiroshi Kamiyama, Shori Takahashi
BACKGROUND: Serum N-terminal pro-brain natriuretic peptide (NT-proBNP) tends to rise in acute phase Kawasaki disease (KD), but the cause of NT-proBNP elevation has not been clarified. In a previous study, cardiac function evaluated on 2-D echocardiography (2D-E) such as ejection fraction was normal, but this does not reflect subtle changes in cardiac dysfunction, and hence the association between cardiac function and NT-proBNP elevation is still controversial. The aim of this study was therefore to elucidate the influence of cardiac function on NT-proBNP elevation, by evaluating cardiac function via strain on 3-D speckle tracking imaging (3D-STI), in acute and subacute KD patients...
April 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29320324/spectrum-of-coronary-artery-aneurysms-from-the-radiologic-pathology-archives
#16
Jean Jeudy, Charles S White, Seth J Kligerman, Jonathan L Killam, Allen P Burke, Jacob W Sechrist, Amar B Shah, Rydhwana Hossain, Aletta Ann Frazier
Advances in medical diagnosis reveal that coronary artery aneurysms (CAAs) may develop in several clinical scenarios and manifest variable symptoms, imaging appearances, and outcomes. Aneurysms are pathologically classified into three groups: atherosclerotic, inflammatory, and noninflammatory. The last category is associated with congenital, inherited, and connective tissue disorders. Overlap exists among the groups, because secondary atherosclerotic change may be present in an aneurysm of any cause. Atherosclerosis is the most common cause of CAAs in adults, and inflammation is considered the underlying mechanism...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29305035/clinical-utility-of-left-atrial-strain-in-children-in-the-acute-phase-of-kawasaki-disease
#17
Soo Jung Kang, Yoo Won Kwon, Seo Jung Hwang, Hyo Jin Kim, Bo Kyeong Jin, Dong Keon Yon
BACKGROUND: We aimed to evaluate the diagnostic utility of peak left atrial longitudinal strain (PALS) during left ventricular (LV) systole to differentiate children in the acute phase of Kawasaki disease (aKD) from controls. We also aimed to compare the diagnostic utility of PALS with those of conventional echocardiographic indices of diastolic function. METHODS: Retrospectively measured PALS, LV longitudinal peak systolic strain, and strain rate obtained via velocity vector imaging were compared in a derivation cohort comprising 95 aKD and 67 controls...
March 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29239297/dynamic-flow-imaging-using-320-detector-row-ct-and-motion-coherence-analysis-in-coronary-aneurysms-associated-with-kawasaki-disease
#18
Yamato Shimomiya, Michinobu Nagao, Yuzo Yamasaki, Takashi Shirasaka, Masatoshi Kondo, Tsukasa Kojima, Akihiro Nishie, Kenichiro Yamamura, Hiroshi Honda
Introduction We propose a new dynamic flow imaging using 320-detector row CT, and investigate the assessment of coronary flow in aneurysms of Kawasaki disease in adulthood. METHODS: Six patients with Kawasaki disease and coronary aneurysms associated (26.7 years old) and six controls were enrolled. Dynamic coronary CT angiography with 320-row CT was continuously performed at mid-diastole throughout 15-25 cardiac cycles with prospective Electrocardiogram gating after injection of contrast media...
March 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29239028/recovery-of-myocardial-mechanics-in-kawasaki-disease-demonstrated-by-speckle-tracking-and-tissue-doppler-methods
#19
Emine Azak, Ibrahim Ilker Cetin, Hazım A Gursu, Ayse Esin Kibar, Murat Surucu, Ali Orgun, Utku Pamuk
AIM: To investigate myocardial deformation and function during treatment for Kawasaki disease (KD) in children. METHODS: We performed speckle tracking echocardiography (STE) and tissue Doppler imaging (TDI) in 15 children with KD and 15 healthy children during treatment for KD. STE was performed for longitudinal and circumferential strain (S) and strain rate (SR) at the left ventricle (LV) and for longitudinal S and SR at the right ventricle (RV). TDI was performed at the base of interventricular septum (IVS), LV, and RV...
March 2018: Echocardiography
https://www.readbyqxmd.com/read/29232024/myocardial-perfusion-reserve-index-in-children-with-kawasaki-disease
#20
Richard M Friesen, Michal Schäfer, Pei-Ni Jone, Nana Appiawiah, Daniel Vargas, Brian Fonseca, Michael V DiMaria, Uyen Truong, LaDonna Malone, Lorna P Browne
BACKGROUND: Coronary artery lesions in patients with Kawasaki disease (KD) can impair myocardial perfusion, yet evaluation of perfusion defects by cardiac magnetic resonance (MR) in children is often qualitative. PURPOSE: In this study we aimed to use a quantitative method of myocardial perfusion using stress cardiac MR-derived myocardial perfusion reserve index (MPRI) in children with KD and compare MPRI with ventricular mechanical performance evaluated by cardiac MR strain analysis...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
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