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imaging in kawasaki disease

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https://www.readbyqxmd.com/read/28487777/severe-dilatation-of-coronary-artery-ostium-complicating-sinus-of-valsalva-aneurysm-differential-diagnosis-and-review-of-the-literature
#1
Paul Bamford, Nicholas Collins
Coronary artery dilatation may be due to various aetiologies including congenital anomalies, atherosclerotic coronary disease, and Kawasakis disease. We describe a case characterised by apparent severe dilatation of the right coronary artery ostium in an asymptomatic male. Subsequent imaging and surgical intervention documented the presence of a sinus of Valsalva aneurysm extending into the ostium of the right coronary artery. This represents an unusual manifestation of a sinus of Valsalva aneurysm. The underlying pathophysiology, differential diagnosis, role of surgical management, and outcomes are discussed...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28469927/clinical-course-of-pituitary-function-and-image-in-igg4-related-hypophysitis
#2
Takatoshi Anno, Fumiko Kawasaki, Maiko Takai, Ryo Shigemoto, Yuki Kan, Hideaki Kaneto, Tomoatsu Mune, Kohei Kaku, Niro Okimoto
A 76-year-old man had a hypopituitarism including adrenal insufficiency, hypogonadism and hypothyroidism. Based on various findings including the swelling of the pituitary gland, increase of serum IgG4 level and abundant IgG4-positive plasma cell infiltration in immunostaining of the pituitary gland, we diagnosed this subject as IgG4-related hypophysitis. In general, a high-dose glucocorticoid treatment is effective for IgG4-related disease. His clinical symptom, laboratory data and adrenal insufficiency were almost improved without any therapy...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28427379/novel-mutation-identified-in-severe-early-onset-tumor-necrosis-factor-receptor-associated-periodic-syndrome-a-case-report
#3
Suhas M Radhakrishna, Amy Grimm, Lori Broderick
BACKGROUND: Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) is the second most common heritable autoinflammatory disease, typically presenting in pre-school aged children with fever episodes lasting 1-3 weeks. Systemic symptoms can include rash, myalgia, ocular inflammation, and serositis. CASE PRESENTATION: Here we report an unusual presentation of TRAPS in a 7 month old girl who presented with only persistent fever. She was initially diagnosed with incomplete Kawasaki Disease and received IVIG and infliximab; however, her fevers quickly recurred...
April 20, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28271012/deep-feature-learning-for-automatic-tissue-classification-of-coronary-artery-using-optical-coherence-tomography
#4
Atefeh Abdolmanafi, Luc Duong, Nagib Dahdah, Farida Cheriet
Kawasaki disease (KD) is an acute childhood disease complicated by coronary artery aneurysms, intima thickening, thrombi, stenosis, lamellar calcifications, and disappearance of the media border. Automatic classification of the coronary artery layers (intima, media, and scar features) is important for analyzing optical coherence tomography (OCT) images recorded in pediatric patients. OCT has been known as an intracoronary imaging modality using near-infrared light which has recently been used to image the inner coronary artery tissues of pediatric patients, providing high spatial resolution (ranging from 10 to 20 μm)...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28239546/functional-hemispherotomy-in-rasmussen-syndrome-in-the-absence-of-classic-mri-findings
#5
Yasunori Nagahama, Charuta Joshi, Brian Dlouhy, Angela Y Wu, Taylor J Abel, Gary Baumbach, Hiroto Kawasaki
A 7-year-old previously healthy girl presented with a left-sided focal seizure without impaired consciousness and subsequently developed epilepsia partialis continua. Initial MRI was normal, and the subsequent images only showed a focal T2/FLAIR hyperintense area without cortical atrophy. She was diagnosed with Rasmussen syndrome by pathology and promptly treated with functional hemispherotomy. Rasmussen syndrome is a rare progressive neurological disorder, the only definitive cure for which is hemispheric disconnection...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28193446/usefulness-of-calcium-scoring-as-a-screening-examination-in-patients-with-a-history-of-kawasaki-disease
#6
Andrew M Kahn, Matthew J Budoff, Lori B Daniels, Jun Oyamada, John B Gordon, Jane C Burns
Subsets of patients with a remote history of Kawasaki disease (KD) have coronary artery aneurysms with associated risks of late morbidity. In a pilot study, we previously showed that computed tomography (CT) coronary artery calcium (CAC) scoring detects late CAC in patients with aneurysms and a remote history of KD. We performed CT calcium volume scoring in 166 subjects (median age 19.5 years) with a remote history of KD (median interval from KD to CT 15.1 years). Coronary arteries were classified as normal (n = 100), transiently dilated (n = 23), persistently dilated (n = 10), remodeled aneurysm (n = 9), or aneurysm (n = 24) based on echocardiography...
April 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28169555/aspiration-thrombectomy-and-intracoronary-tirofiban-via-guideliner-%C3%A2-catheter-for-a-thrombosed-aneurysmal-vessel
#7
James Fry, Ali Naqvi, Amit Bahia, Arnold Seto
A 52-year-old Asian male with no traditional risk factors for coronary artery disease presented with acute coronary syndrome. Coronary angiography showed complete thrombotic occlusion of the left circumflex with a large thrombus burden in the setting of diffuse aneurysmal enlargement of the coronary arteries consistent with antecedent Kawasaki disease. Manual thrombectomy with adjunctive intracoronary tirofiban was performed utilizing the GuideLiner catheter. Stent implantation was deferred. Follow-up imaging 48 h later showed preserved coronary flow and decreased thrombus burden...
February 7, 2017: Future Cardiology
https://www.readbyqxmd.com/read/28073668/drug-eluting-stenting-for-femoropopliteal-lesions-followed-by-cilostazol-treatment-reduces-stent-restenosis-in-patients-with-symptomatic-peripheral-artery-disease
#8
RANDOMIZED CONTROLLED TRIAL
Kan Zen, Mitsuyoshi Takahara, Osamu Iida, Yoshimitsu Soga, Daizo Kawasaki, Shinsuke Nanto, Hiroyoshi Yokoi, Satoaki Matoba
BACKGROUND: Cilostazol improves clinical endovascular therapy outcomes for femoropopliteal (FP) lesions in patients with symptomatic peripheral arterial disease, but whether it also has clinical benefits for patients after drug-eluting stent implantation remains unclear. METHODS: This study is a subanalysis of the ZilvEr PTX for tHe Femoral ArterY and Proximal Popliteal ArteRy (ZEPHYR) study, a prospective multicenter study investigating FP lesions treated with the Zilver (Cook Medical, Bloomington, Ind) paclitaxel-eluting stent...
March 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28041803/development-of-radioiodinated-acridine-derivatives-for-in-vivo-imaging-of-prion-deposits-in-the-brain
#9
Masao Kawasaki, Takeshi Fuchigami, Nobuya Kobashi, Takehiro Nakagaki, Kazunori Sano, Ryuichiro Atarashi, Sakura Yoshida, Mamoru Haratake, Noriyuki Nishida, Morio Nakayama
Prion diseases are caused by deposition of abnormal prion protein aggregates (PrP(Sc)) in the central nervous system. This study aimed to develop in vivo imaging probes that can detect cerebral PrP(Sc) deposits. We synthesized several quinacrine-based acridine (AC) derivatives with 2,9-substitution and radioiodinated them. The AC derivatives were evaluated as prion-imaging probes using recombinant mouse prion protein (rMoPrP) aggregates and brain sections of mouse-adapted bovine spongiform encephalopathy (mBSE)-infected mice...
December 19, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28032809/rationale-and-methodology-for-a-community-based-study-of-diabetic-retinopathy-in-an-indonesian-population-with-type-2-diabetes-mellitus-the-jogjakarta-eye-diabetic-study-in-the-community
#10
Muhammad B Sasongko, Angela N Agni, Firman S Wardhana, Satya P Kotha, Prateek Gupta, Tri W Widayanti, Supanji, Felicia Widyaputri, Rifa Widyaningrum, Tien Y Wong, Ryo Kawasaki, Jie Jin Wang, Suhardjo Pawiroranu
PURPOSE: There are no available data about diabetic retinopathy (DR) in the Indonesian population. This report summarizes the rationale and study design of the Jogjakarta Eye Diabetic Study in the Community (JOGED.COM), a community-based study to estimate the prevalence and risk factors of DR in persons with type 2 diabetes in Jogjakarta, Indonesia. METHODS: The JOGED.COM aimed to examine a cross-sectional sample of 1200 persons with type 2 diabetes aged 30 years and older residing in the study area...
February 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28000002/stress-perfusion-magnetic-resonance-imaging-to-detect-coronary-artery-lesions-in-children
#11
Chodchanok Vijarnsorn, Michelle Noga, Daryl Schantz, Dion Pepelassis, Edythe B Tham
BACKGROUND: Stress perfusion cardiovascular magnetic resonance (CMR) is used widely in adult ischemic heart disease, but data in children is limited. We sought to evaluate feasibility, accuracy and prognostic value of stress CMR in children with suspected coronary artery disease (CAD). METHODS: Stress CMR was reviewed from two pediatric centers over 5 years using a standard pharmacologic protocol. Wall motion abnormalities, perfusion deficits and late enhancement were correlated with coronary angiogram (CAG) when available, and clinical status at 1 year follow-up for major adverse cardiovascular events (MACE; coronary revascularization, non-fatal myocardial infarction and death due to CAD) was recorded...
December 20, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27872783/multimodality-cardiac-imaging-in-a-patient-with-kawasaki-disease-and-giant-aneurysms
#12
Ranjini Srinivasan, Rachel Weller, Anjali Chelliah, Andrew J Einstein
Kawasaki disease is a well-known cause of acquired cardiac disease in the pediatric and adult population, most prevalent in Japan but also seen commonly in the United States. In the era of intravenous immunoglobulin (IVIG) treatment, the morbidity associated with this disease has decreased, but it remains a serious illness. Here we present the case of an adolescent, initially diagnosed with Kawasaki disease as an infant, that progressed to giant aneurysm formation and calcification of the coronary arteries...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27857465/unusual-imaging-presentation-of-infantile-atypical-kawasaki-disease
#13
Nishith Kumar, Mahesh Kumar Mittal, Mukul Sinha, Arpita Gupta, Brij Bhushan Thukral
Kawasaki disease is a systemic medium vessel vasculitis of unknown etiology affecting children under 5 years of age. There are no specific diagnostic tests, and thus, the diagnosis of the disease is primarily made on the basis of clinical criteria. Unusual presentations of Kawasaki disease have been variably reported from different parts of the world. However, presentation of the disease in the form of peripheral thromboembolism and florid non-coronary aneurysms has rarely been described This report describes the imaging findings in infantile atypical Kawasaki disease with aneurysms of multiple medium-sized arteries, including coronary arteries, emphasizing the detection of clinically silent aneurysms in the disease...
July 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27789453/utility-of-a-multiparametric-quantitative-mri-model-that-assesses-myelin-and-edema-for-evaluating-plaques-periplaque-white-matter-and-normal-appearing-white-matter-in-patients-with-multiple-sclerosis-a-feasibility-study
#14
A Hagiwara, M Hori, K Yokoyama, M Y Takemura, C Andica, K K Kumamaru, M Nakazawa, N Takano, H Kawasaki, S Sato, N Hamasaki, A Kunimatsu, S Aoki
BACKGROUND AND PURPOSE: T1 and T2 values and proton density can now be quantified on the basis of a single MR acquisition. The myelin and edema in a voxel can also be estimated from these values. The purpose of this study was to evaluate a multiparametric quantitative MR imaging model that assesses myelin and edema for characterizing plaques, periplaque white matter, and normal-appearing white matter in patients with MS. MATERIALS AND METHODS: We examined 3T quantitative MR imaging data from 21 patients with MS...
October 27, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27630399/absolute-and-relative-reliability-of-lumbar-interspinous-process-ultrasound-imaging-measurements
#15
Ryosuke Tozawa, Munenori Katoh, Hidefumi Aramaki, Tsubasa Kawasaki, Yuichi Nishikawa, Tsuneo Kumamoto, Osamu Fujinawa
[Purpose] The intra- and inter-examiner reliabilities of lumbar interspinous process distances measured by ultrasound imaging were examined. [Subjects and Methods] The subjects were 10 males who had no history of orthopedic diseases or dysfunctions. Ten lumbar interspinous images from 360 images captured from 10 subjects were selected. The 10 images were measured by nine examiners. The lumbar interspinous process distance measurements were performed five times by each examiner. In addition, four of the nine examiners measured the distances again after 4 days for test-retest analysis...
August 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27576457/combined-blood-pool-and-extracellular-contrast-agents-for-pediatric-and-young-adult-cardiovascular-magnetic-resonance-imaging
#16
Joyce T Johnson, Joshua D Robinson, Jie Deng, Cynthia K Rigsby
BACKGROUND: A comprehensive cardiac magnetic resonance (cardiac MR) study including both late gadolinium enhancement (LGE) and MR angiography may be indicated for patients with a history of acquired or congenital heart disease. OBJECTIVE: To study the novel use of an extracellular agent for assessment of LGE combined with a blood pool contrast agent for detailed MR angiography evaluation to yield a comprehensive cardiac MR study in these patients. MATERIALS AND METHODS: We reviewed clinical cardiac MR studies utilizing extracellular and blood pool contrast agents and noted demographics, clinical data and adverse events...
December 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27394424/myocardial-layers-specific-strain-analysis-for-the-acute-phase-of-infant-kawasaki-disease
#17
Lucy Youngmin Eun, Ji Hong Kim, Jo Won Jung, Jae Young Choi
Recently, the prevalence of infant Kawasaki disease (KD) has increased. However, the myocardial functional analysis of infant KD can be difficult and rarely reported. The purpose of this study was to investigate layer specific myocardial strain analysis for better assessment of the acute period in infant KD. The study retrospectively reviewed the echocardiographic data of 25 infant patients with KD at the acute phase. With advanced imaging, pulsed tissue Doppler velocity data, myocardial strain with three layers specific analysis was performed...
December 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27371760/asymptomatic-kawasaki-disease-in-a-3-month-old-infant
#18
Helene Pinches, Katherine Dobbins, Sarah Cantrell, Joseph May, Joseph Lopreiato
Kawasaki disease (KD) is the leading cause of acquired heart disease in children in the United States. It is a systemic vasculitis characterized by diffuse inflammation of medium and small blood vessels. If untreated it can lead to myocardial infarction, ischemic heart disease, or sudden death. Early recognition and treatment decrease the incidence of coronary consequences, resulting in improved clinical outcomes. Incomplete KD is much less likely to fulfill major clinical diagnostic criteria. Infants <12 months of age are more likely to have an incomplete presentation, and children <6 months of age are more likely to develop cardiac complications...
August 2016: Pediatrics
https://www.readbyqxmd.com/read/27363224/-relationship-between-coronary-plaque-stability-evaluated-by-intravascular-ultrasound-and-laboratory-parameters
#19
REVIEW
Masanori Kawasaki, Masamitsu Iwasa, Hiromitsu Kanamori, Yoshihisa Yamada, Toshiki Tanaka, Hiroaki Ushikoshi, Yasushi Ohno, Atsushi Mikami, Kazuhiko Nishigaki, Shinya Minatoguchi
Tissue characteristics of coronary plaque have been reported to be associated with cardiovascular events. The stabilization of vulnerable tissue components such as the lipid pool rather than regression of the plaque volume is considered to be of major benefit in the reduction of cardiovascular events. Conventional echocardiography, especially intravascular ultrasound imaging (IVUS), is widely used to determine calcification and the three layers of the arterial wall. However, differentiation of the lipid pool from fibrous tissue using the echo intensity is difficult...
March 2016: Rinsho Byori. the Japanese Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27342599/picosecond-pulsed-infrared-laser-tuned-to-amide-i-band-dissociates-polyglutamine-fibrils-in-cells
#20
Takayasu Kawasaki, Gaku Ohori, Tomoyuki Chiba, Koichi Tsukiyama, Kazuhiro Nakamura
Amyloid fibrils are causal substances for serious neurodegenerative disorders and amyloidosis. Among them, polyglutamine fibrils seen in multiple polyglutamine diseases are toxic to neurons. Although much efforts have been made to explore the treatments of polyglutamine diseases, there are no effective drugs to block progression of the diseases. We recently found that a free electron laser (FEL), which has an oscillation wavelength at the amide I band (C = O stretch vibration mode) and picosecond pulse width, was effective for conversion of the fibril forms of insulin, lysozyme, and calcitonin peptide into their monomer forms...
September 2016: Lasers in Medical Science
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