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imaging in kawasaki disease

Ryosuke Tozawa, Munenori Katoh, Hidefumi Aramaki, Tsubasa Kawasaki, Yuichi Nishikawa, Tsuneo Kumamoto, Osamu Fujinawa
[Purpose] The intra- and inter-examiner reliabilities of lumbar interspinous process distances measured by ultrasound imaging were examined. [Subjects and Methods] The subjects were 10 males who had no history of orthopedic diseases or dysfunctions. Ten lumbar interspinous images from 360 images captured from 10 subjects were selected. The 10 images were measured by nine examiners. The lumbar interspinous process distance measurements were performed five times by each examiner. In addition, four of the nine examiners measured the distances again after 4 days for test-retest analysis...
August 2016: Journal of Physical Therapy Science
Joyce T Johnson, Joshua D Robinson, Jie Deng, Cynthia K Rigsby
BACKGROUND: A comprehensive cardiac magnetic resonance (cardiac MR) study including both late gadolinium enhancement (LGE) and MR angiography may be indicated for patients with a history of acquired or congenital heart disease. OBJECTIVE: To study the novel use of an extracellular agent for assessment of LGE combined with a blood pool contrast agent for detailed MR angiography evaluation to yield a comprehensive cardiac MR study in these patients. MATERIALS AND METHODS: We reviewed clinical cardiac MR studies utilizing extracellular and blood pool contrast agents and noted demographics, clinical data and adverse events...
August 30, 2016: Pediatric Radiology
Lucy Youngmin Eun, Ji Hong Kim, Jo Won Jung, Jae Young Choi
: Recently, the prevalence of infant Kawasaki disease (KD) has increased. However, the myocardial functional analysis of infant KD can be difficult and rarely reported. The purpose of this study was to investigate layer specific myocardial strain analysis for better assessment of the acute period in infant KD. The study retrospectively reviewed the echocardiographic data of 25 infant patients with KD at the acute phase. With advanced imaging, pulsed tissue Doppler velocity data, myocardial strain with three layers specific analysis was performed...
July 9, 2016: Pediatric Cardiology
Helene Pinches, Katherine Dobbins, Sarah Cantrell, Joseph May, Joseph Lopreiato
Kawasaki disease (KD) is the leading cause of acquired heart disease in children in the United States. It is a systemic vasculitis characterized by diffuse inflammation of medium and small blood vessels. If untreated it can lead to myocardial infarction, ischemic heart disease, or sudden death. Early recognition and treatment decrease the incidence of coronary consequences, resulting in improved clinical outcomes. Incomplete KD is much less likely to fulfill major clinical diagnostic criteria. Infants <12 months of age are more likely to have an incomplete presentation, and children <6 months of age are more likely to develop cardiac complications...
August 2016: Pediatrics
Masanori Kawasaki, Masamitsu Iwasa, Hiromitsu Kanamori, Yoshihisa Yamada, Toshiki Tanaka, Hiroaki Ushikoshi, Yasushi Ohno, Atsushi Mikami, Kazuhiko Nishigaki, Shinya Minatoguchi
Tissue characteristics of coronary plaque have been reported to be associated with cardiovascular events. The stabilization of vulnerable tissue components such as the lipid pool rather than regression of the plaque volume is considered to be of major benefit in the reduction of cardiovascular events. Conventional echocardiography, especially intravascular ultrasound imaging (IVUS), is widely used to determine calcification and the three layers of the arterial wall. However, differentiation of the lipid pool from fibrous tissue using the echo intensity is difficult...
March 2016: Rinsho Byori. the Japanese Journal of Clinical Pathology
Takayasu Kawasaki, Gaku Ohori, Tomoyuki Chiba, Koichi Tsukiyama, Kazuhiro Nakamura
Amyloid fibrils are causal substances for serious neurodegenerative disorders and amyloidosis. Among them, polyglutamine fibrils seen in multiple polyglutamine diseases are toxic to neurons. Although much efforts have been made to explore the treatments of polyglutamine diseases, there are no effective drugs to block progression of the diseases. We recently found that a free electron laser (FEL), which has an oscillation wavelength at the amide I band (C = O stretch vibration mode) and picosecond pulse width, was effective for conversion of the fibril forms of insulin, lysozyme, and calcitonin peptide into their monomer forms...
September 2016: Lasers in Medical Science
Hiroyuki Watanabe, Azusa Kawasaki, Kohei Sano, Masahiro Ono, Hideo Saji
In vivo imaging of β-amyloid (Aβ) aggregates consisting of Aβ(1-40) and Aβ(1-42) peptides by positron emission tomography (PET) contributes to the diagnosis and therapy for Alzheimer's disease (AD). Because (64)Cu (t1/2=12.7h) is a radionuclide for PET with a longer physical half-life than (11)C (t1/2=20min) and (18)F (t1/2=110min), it is an attractive radionuclide for the development of Aβ imaging probes that are suitable for routine use. In the present study, we designed and synthesized two novel (64)Cu labeled benzofuran derivatives and evaluated their utility as PET imaging probes for Aβ aggregates...
August 15, 2016: Bioorganic & Medicinal Chemistry
Hideyuki Hakui, Takahisa Yamada, Shunsuke Tamaki, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Masashi Ishimi, Yoshihiro Sato, Masahiro Seo, Tatsuhisa Ozaki, Iyo Ikeda, Eiji Fukuhara, Yasushi Sakata, Masatake Fukunami
Liver dysfunction has a prognostic impact on the outcomes of patients with advanced heart failure (HF). The model for end-stage liver disease (MELD) score is a robust system for rating liver dysfunction, and a high score has been shown to be associated with a poor prognosis in ambulatory patients with HF. In addition, cardiac metaiodobenzylguanidine (MIBG) imaging provides prognostic information in patients with chronic HF (CHF). However, the long-term predictive value of combining the MELD score and cardiac MIBG imaging in patients with CHF has not been elucidated...
June 15, 2016: American Journal of Cardiology
Benjamin Frank, Jesse Davidson, Suhong Tong, Blake Martin, Heather Heizer, Marsha S Anderson, Mary P Glode, Samuel R Dominguez, Pei-Ni Jone
BACKGROUND: Kawasaki Disease (KD), a systemic vasculitis of medium sized vessels, is the most common cause of acquired heart disease among children in the developed world. Some KD patients demonstrate echocardiographic evidence of depressed myocardial mechanics. However, the incidence, etiology, and reversibility of abnormal mechanics in KD patients remain undefined. METHODS AND RESULTS: We retrospectively studied 41 KD patients and measured myocardial strain and strain rate by velocity vector imaging from pre-treatment and convalescent echocardiograms...
April 2016: Journal of Clinical & Experimental Cardiology
Masanori Abe, Ryuji Fukazawa, Shunichi Ogawa, Makoto Watanabe, Yoshimitsu Fukushima, Tomonari Kiriyama, Hiromitsu Hayashi, Yasuhiko Itoh
BACKGROUND: The coronary arterial lesions of Kawasaki disease are mainly dilative lesions, aneurysms, and stenotic lesions formed before, after, and between aneurysms; these lesions develop in multiple branches resulting in complex coronary hemodynamics. Diagnosis of myocardial ischemia and infarction and evaluation of the culprit coronary arteries and regions is critical to evaluating the treatment and prognosis of patients. This study used hybrid imaging, in which multidetector computed tomographic (CT) images for coronary CT angiography (CCTA) and stress myocardial perfusion single-photon emission CT (SPECT) images were fused...
2016: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Jun Shiraishi, Yuki Matsubara, Takashi Yanagiuchi, Akira Shikuma, Keisuke Shoji, Marie Nishikawa, Daisuke Ito, Masayoshi Kimura, Eigo Kishita, Yusuke Nakagawa, Masayuki Hyogo, Takahisa Sawada, Yoshio Kohno
Rotational atherectomy with/without low-pressure balloon dilation has been a mainstay of interventional treatment for stenosis due to the coronary sequelae of Kawasaki disease (KD). Here, we report a restenosis case of probable coronary sequelae of KD treated with rotational atherectomy with low-pressure 2.5-mm balloon dilation 6 months previously. Under the guidance of optical frequency domain imaging, we performed rotational atherectomy followed by 2.5-mm drug-coated balloon (DCB) dilation for an atherosclerotic restenosis at the inlet of a calcified aneurysm in the proximal left anterior descending coronary artery...
May 25, 2016: International Heart Journal
A Dehaene, A Jacquier, C Falque, G Gorincour, J Y Gaubert
Acquired coronary diseases include aneurysms, fistulae, dissections, and stenosis. Aneurysms may occur secondarily to Kawasaki disease, a childhood vasculitis, the prognosis of which depends on the coronary involvement, or they may be degenerative, infectious, inflammatory, or traumatic in origin. Fistulae develop between the coronary arterial system and a pulmonary or bronchial artery, or cardiac cavity. Dissections may occur spontaneously or may be post-traumatic. These coronary abnormalities may be found incidentally or may present as complications, infarction or rupture...
May 2016: Diagnostic and Interventional Imaging
Taiki Nozaki, Yuka Morita, Daisuke Hasegawa, Akari Makidono, Yuri Yoshimoto, Jay Starkey, Isao Kusakawa, Atsushi Manabe, Yukihisa Saida
BACKGROUND: Differentiating Kawasaki disease (KD) from cervical lymphadenitis (CL) is clinically difficult yet essential given the treatments and outcomes differ significantly. Research regarding differentiating between KD and CL using US and CT is limited. The purpose of this study is to investigate imaging findings that may differentiate KD from CL, comparing cervical US and CT findings in patients with KD and CL. METHODS: We retrospectively reviewed cervical US images of 25 KD patients and 25 CL patients and CT images of 14 KD patients, and 14 CL patients...
April 21, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Kenichi Suga, Miki Inoue, Akemi Ono, Tomomasa Terada, Masami Kawahito, Kazuhiro Mori
Severe-type Kawasaki disease (KD) complicated by serious myocarditis and encephalopathy can be successfully treated without abnormality of the coronary arteries by steroid pulse treatment and intravenous immunoglobulin (IVIg). A 4-year-old Japanese girl was diagnosed with KD due to a 6-day history of fever, rash, flushed lips, conjunctival hyperemia, palmar edema, and cervical lymphadenopathy. The day after initiation of IVIg and aspirin, cardiac gallop rhythm was identified. Cardiac ultrasonography revealed severe left ventricular dysfunction...
2016: Journal of Medical Investigation: JMI
Xin Jiang, Shusheng Liao, Bin Xiong, Lei Zheng, Huijia Zhu, Xuelian Zhu, Xianda Ni, Xiangwu Zheng, Bin Chen
The coincidence of 3 different rare coronary artery anomalies is extremely rare, and has not been reported so far.We report multiple imaging findings of a giant coronary artery aneurysm, which has a fistulous connection to the right ventricle associated with anomalous origin of the anterior descending coronary artery from the right coronary artery in a 67-year-old woman who suffered with a 20-year history of progressively chest distress on exertion and a history of untreated Kawasaki disease in her childhood...
March 2016: Medicine (Baltimore)
Béatrice Miltner, Alain Poncelet, Stéphane Moniotte
No abstract text is available yet for this article.
March 2016: Annals of Thoracic Surgery
Kensuke Fujii, Toshikatsu Nitta, Hiroshi Kawasaki, Jun Kataoka, Tomo Tominaga, Yoshihiro Inoue, Eiji Kadota, Takashi Ishibashi, Kazuhisa Uchiyama
We herein report a case of anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm (IPMN). A 68-year-old Japanese woman was admitted to our hospital complaining of fatigue. Computed tomography revealed an irregular mass in the pancreatic head, which displayed high-signal intensity on diffusion-weighted magnetic resonance imaging. Accordingly, the patient was diagnosed with pancreatic cancer and underwent pancreaticoduodenectomy. The histopathological findings revealed intraductal papillary proliferative changes involving the main and branch ducts of the pancreatic head...
January 2016: Molecular and Clinical Oncology
Zhen Li, Zhou Tan, Shiying Hao, Bo Jin, Xiaohong Deng, Guang Hu, Xiaodan Liu, Jie Zhang, Hua Jin, Min Huang, John T Kanegaye, Adriana H Tremoulet, Jane C Burns, Jianmin Wu, Harvey J Cohen, Xuefeng B Ling
OBJECTIVES: Kawasaki disease (KD) is an acute pediatric vasculitis of infants and young children with unknown etiology and no specific laboratory-based test to identify. A specific molecular diagnostic test is urgently needed to support the clinical decision of proper medical intervention, preventing subsequent complications of coronary artery aneurysms. We used a simple and low-cost colorimetric sensor array to address the lack of a specific diagnostic test to differentiate KD from febrile control (FC) patients with similar rash/fever illnesses...
2016: PloS One
Abdel-Naser Ghareep, Maryam Alkuwari, Francis Willington, Wojciech Szmigielski
BACKGROUND: Kawasaki Disease (KD) is a rare acute febrile illness due to multi-organ vasculitis. It most often affects children under five years of age. Coronary artery aneurysms are seen in about 25% of children with KD. Selective invasive coronary angiography was considered to be the gold standard for diagnosis and follow-up of coronary artery aneurysms, thrombosis and stenosis in patients with KD. Echocardiography is a non-invasive tool for imaging of this condition but it does have some limitations...
2015: Polish Journal of Radiology
Kiyofumi Yamada, Masanori Kawasaki, Shinichi Yoshimura, Manabu Shirakawa, Kazutaka Uchida, Seigo Shindo, Shuji Nishida, Yasuhiro Iwamoto, Shigehiro Nakahara, Yoshikazu Sato
BACKGROUND: Carotid atherosclerotic disease is recognized as an important risk factor for brain ischemic events. However, high-grade stenosis does not always cause ischemic strokes, whereas moderate-grade stenosis may often cause ischemic strokes. It has been reported that there is an association between carotid intraplaque hemorrhage (IPH) and new cerebral ischemic events. The purpose of this study was to elucidate the relationship between high-intensity signals (HIS) on maximum intensity projection (MIP) images from routine 3-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) and prior ischemic strokes in the patients with moderate carotid stenosis...
2016: Cerebrovascular Diseases
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