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Pick's Disease

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https://www.readbyqxmd.com/read/29032655/microglial-involvement-in-the-development-of-olfactory-dysfunction
#1
REVIEW
Yoojin Seo, Hyung-Sik Kim, Kyung-Sun Kang
Olfaction is one of the oldest and important senses for life. Olfactory impairment is the most common clinical manifestation among elderly, and its prevalence is sharply increased with aging. Importantly, growing evidence has shown that olfactory dysfunction is the first sign of neurodegeneration, indicating the importance of olfactory assessment as an early diagnostic marker for the detection of neurological disorders. In this review, we described the nature of olfactory dysfunction and the advantage of animal models in olfaction study with brief introduction of olfactory behavior tests widely used in this field...
October 13, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29031695/-hesitant-compliers-qualitative-analysis-of-concerned-fully-vaccinating-parents
#2
Stephanie L Enkel, Katie Attwell, Thomas L Snelling, Hayley E Christian
OBJECTIVE: Some parents are hesitant about vaccines and yet still vaccinate their children. Vaccine behaviours are not fixed and parents who are concerned but nonetheless adherent to standard schedules could switch to an unconventional schedule, delaying or cherry-picking vaccines. There is a need to better understand vaccine hesitancy in specific contexts, acknowledging cultural and geographical variation, to ensure interventions targeting hesitancy are well directed and received. METHODS: To identify the behaviours, knowledge and attitudes of 'hesitant compliers' in Perth, Western Australia, nine one-on-one in-depth interviews were conducted with vaccinating parents of children (<5 years) who were identified as being hesitant...
October 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29030789/foreign-bodies-in-sigmoid-colon-diverticulosis
#3
REVIEW
Ellen Ross, Patricia McKenna, John H Anderson
This review addresses the management of sigmoid colon diverticular disease associated with foreign bodies. In addition, two novel cases are presented. One case describes the management of diverticular bleeding secondary to a chicken bone and the other case reports retrieval of a retained EndoRings™ Device. The review identified 40 relevant publications including 50 subjects. Foreign bodies within sigmoid diverticular disease may be associated with inflammation, perforation, abscess and fistula. In current practice, diagnosis is often achieved with CT scan...
October 13, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29029145/blood-meal-source-characterization-using-illumina-sequencing-in-the-chagas-disease-vector-rhodnius-pallescens-hemiptera-reduviidae-in-panam%C3%A3
#4
Troy J Kieran, Nicole L Gottdenker, Christina P Varian, Azael Saldaña, Nicolas Means, Darlisha Owens, Jose E Calzada, Travis C Glenn
Accurate blood meal identification is critical to understand hematophagous vector-host relationships. This study describes a customizable Next-Generation Sequencing (NGS) approach to identify blood meals from Rhodnius pallescens (Hemiptera: Reduviidae) triatomines using multiple barcoded primers and existing software to pick operational taxonomic units and match sequences for blood meal identification. We precisely identified all positive control samples using this method and further examined 74 wild-caught R...
October 4, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29026097/chemosensing-of-honeybee-parasite-varroa-destructor-transcriptomic-analysis
#5
Nurit Eliash, Nitin K Singh, Starlin Thangarajan, Noa Sela, Dena Leshkowitz, Yosi Kamer, Ilia Zaidman, Ada Rafaeli, Victoria Soroker
Chemosensing is a primary sense in nature, however little is known about its mechanism in Chelicerata. As a model organism we used the mite Varroa destructor, a key parasite of honeybees. Here we describe a transcriptomic analysis of two physiological stages for the Varroa foreleg, the site of primary olfactory organ. The transcriptomic analysis revealed transcripts of chemosensory related genes belonging to several groups. These include Niemann-Pick disease protein, type C2 (NPC2), gustatory receptors (GRs), ionotropic receptors (IRs), sensory neuron membrane proteins (SNMPs) and odorant binding proteins (OBP)...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28991491/nanowire-aptasensors-for-electrochemical-detection-of-cell-secreted-cytokines
#6
Ying Liu, Ali Rahimian, Sergiy Krylyuk, Tam Vu, Bruno Crulhas, Gulnaz Stybayeva, Meruyert Imanbekova, Dong-Sik Shin, Albert Davydov, Alexander Revzin
Cytokines are small proteins secreted by immune cells in response to pathogens/infections; therefore, these proteins can be used in diagnosing infectious diseases. For example, release of a cytokine interferon (IFN)-γ from T-cells is used for blood-based diagnosis of tuberculosis (TB). Our lab has previously developed an atpamer-based electrochemical biosensor for rapid and sensitive detection of IFN-γ. In this study, we explored the use of silicon nanowires (NWs) as a way to create nanostructured electrodes with enhanced sensitivity for IFN-γ...
October 9, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28988886/the-ceramide-activated-protein-phosphatase-sit4-impairs-sphingolipid-dynamics-mitochondrial-function-and-lifespan-in-a-yeast-model-of-niemann-pick-type-c1
#7
Rita Vilaça, Ivo Barros, Nabil Matmati, Elísio Silva, Telma Martins, Vítor Teixeira, Yusuf A Hannun, Vítor Costa
The Niemann-Pick type C is a rare neurodegenerative disease that results from loss-of-function point mutations in NPC1 or NPC2, which affect the homeostasis of sphingolipids and sterols in human cells. We have previously shown that yeast lacking Ncr1, the orthologue of human NPC1 protein, display a premature ageing phenotype and higher sensitivity to oxidative stress associated with mitochondrial dysfunctions and accumulation of long chain bases. In this study, a lipidomic analysis revealed specific changes in the levels of ceramide species in ncr1Δ cells, including decreases in dihydroceramides and increases in phytoceramides...
October 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28987182/tauopathies
#8
Gabor G Kovacs
Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain. The spectrum of tau pathologies expands beyond the traditionally discussed disease forms like Pick disease, progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease. Emerging entities and pathologies include globular glial tauopathies, primary age-related tauopathy, which includes neurofibrillary tangle dementia, chronic traumatic encephalopathy (CTE), and aging-related tau astrogliopathy...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28984110/neuronal-cytoplasmic-inclusions-in-tau-tdp-43-and-fus-molecular-subtypes-of-frontotemporal-lobar-degeneration-share-similar-spatial-patterns
#9
Richard A Armstrong
The 'prion-like' transfer of pathogenic proteins may play a role in the pathogenesis of frontotemporal lobar degeneration (FTLD). Propagation of such proteins along anatomical pathways may give rise to specific spatial patterns of the 'signature' neuronal cytoplasmic inclusions (NCI) characteristic of these disorders. Hence, the spatial patterns of the NCI were compared in three molecular subtypes of FTLD: (1) two variants of FTLD-tau, viz. cortico-basal degeneration (CBD) and Pick's disease (PiD), (2) FTLD with transactive response (TAR) DNA-binding protein 43(TDP-43)-immunoreactive inclusions (FTLD-TDP), and (3) FTLD with 'fused in sarcoma' (FUS)-immunoreactive inclusions (FTLD-FUS)...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28977750/a-data-independent-mass-spectrometry-approach-for-screening-and-identification-of-dna-adducts
#10
Jingshu Guo, Peter W Villalta, Robert J Turesky
Long-term exposures to environmental toxicants and endogenous electrophiles are causative factors for human diseases including cancer. DNA adducts reflect the internal exposure to genotoxicants and can serve as biomarkers for risk assessment. Liquid chromatography-multistage mass spectrometry (LC-MSn) is the most common method for biomonitoring DNA adducts, generally targeting single exposures and measuring up to several adducts. However, the data often provide limited evidence for a role of a chemical in the etiology of cancer...
October 4, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28969124/improving-the-diagnosis-of-scrub-typhus-by-combining-groel-based-polymerase-chain-reaction-and-igm-elisa
#11
Karthikeyan Anitha Patricia, Sugeerappa Laxmanappa Hoti, Reba Kanungo, Purushothaman Jambulingam, Nair Shashikala, Ashok C Naik
INTRODUCTION: Scrub typhus, an acute febrile illness, caused by Orientia tsutsugamushi, is an important cause of pyrexia of unknown origin in regions of endemicity. This disease is mostly underdiagnosed or misdiagnosed, the reasons for this being a combination of factors which include clinical manifestations that can mimic other infections, lack of easy and reliable diagnostic methods and variation among strains in endemic areas. Hence, easy and reliable methods of diagnosis will contribute to rapid identification and treatment of the infection...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28957010/causes-of-normal-mortality-in-commercial-egg-laying-chickens
#12
Richard M Fulton
In a large population of animals, it is normal to have some die each day from causes not related to disease, which is often referred to as natural causes. In poultry production, this phenomenon is commonly referred to as daily mortality. In egg-producing chickens, many of the natural causes of death are associated with making an egg. The causes of normal mortality in commercial egg-laying chicken flocks have been described very little to date. A commercial chicken egg farm, housing approximately two million single-comb white leghorn chickens (Gallus gallus domesticus) in 16 egg-producing flocks, was visited on a monthly basis to monitor bird health, body conditioning, skeletal integrity, and causes of daily mortality in an attempt to provide early detection of health abnormalities...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28952845/identification-of-movement-strategies-during-the-sit-to-walk-movement-in-patients-with-knee-osteoarthritis
#13
Dimitrios-Sokratis Komaris, Cheral Govind, Andrew Murphy, Alistair Ewen, Philip Riches
Patients with osteoarthritis of the knee commonly alter their movement to compensate for lower limb weakness and alleviate joint pain. Movement alterations may lead to weight-bearing asymmetries, and potentially in the progression of the disease. This study presents a novel numerical procedure for the identification of sit-to-walk strategies and differences in movement habits between control adults and persons with knee osteoarthritis. Ten control and twelve participants with osteoarthritis performed the sit-to-walk task in a motion capture laboratory...
September 27, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28951965/niemann-pick-disease-type-c-in-the-newborn-period-a-single-center-experience
#14
Ersin Gumus, Goknur Haliloglu, Asuman Nur Karhan, Hulya Demir, Figen Gurakan, Meral Topcu, Aysel Yuce
Niemann-Pick disease type C (NPC) is a neurovisceral lysosomal storage disorder with a great variation in clinical spectrum and age at presentation. Clinical features of 10 NPC patients who presented in the newborn period between 1993 and 2015 at our center were retrospectively analyzed. Males and females were equally distributed; there was a history of parental consanguinity (n = 8) and first-degree relative with NPC (n = 3). Patients were symptomatic between 1 and 10 days (mean 3.6 ± 2.6 days). Age at diagnosis was between 1 and 30 days (mean 14...
September 27, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28948412/rapid-fecal-calprotectin-test-and-symptom-index-in-monitoring-the-disease-activity-in-colonic-inflammatory-bowel-disease
#15
Anna-Maija Puolanne, Kaija-Leena Kolho, Henrik Alfthan, Ari Ristimäki, Harri Mustonen, Martti Färkkilä
BACKGROUND: Fecal calprotectin is a reliable surrogate marker for inflammatory activity in inflammatory bowel disease (IBD). AIMS: For the noninvasive monitoring of the activity of colonic inflammation, we validated a symptom index suitable for ulcerative colitis and colonic Crohn's disease. By combining the symptom index with a rapid semi-quantitative calprotectin test, we constructed a new activity index based on the highest AUCs, using histological remission as a reference...
September 25, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28934750/frontotemporal-dementia-caused-by-the-p301l-mutation-in-the-mapt-gene-clinicopathological-features-of-13-cases-from-the-same-geographical-origin-in-barcelona-spain
#16
Sergi Borrego-Écija, Joana Morgado, Leire Palencia-Madrid, Oriol Grau-Rivera, Ramón Reñé, Isabel Hernández, Consuelo Almenar, Mircea Balasa, Anna Antonell, José Luis Molinuevo, Albert Lladó, Marian Martínez de Pancorbo, Ellen Gelpi, Raquel Sánchez-Valle
BACKGROUND/AIMS: We identified and studied 13 patients carrying the P301L mutation in the MAPT gene from the same area (Baix Llobregat County) in Barcelona, Spain. METHODS: The demographic and clinical features were reviewed retrospectively. Detailed neuropathological characterization was obtained in 9 subjects. To investigate the origin of the P301L mutation in these families, 20 single nucleotide polymorphisms (SNPs) in the MAPT gene were analyzed. RESULTS: The mean age at disease onset was 51 years and the mean disease duration was 7 years...
September 22, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28927263/molecular-and-cellular-basis-of-neurodegeneration-in-alzheimer-s-disease
#17
Sangyun Jeong
The most common form of senile dementia is Alzheimer's disease (AD), which is characterized by the extracellular deposition of amyloid beta-peptide (Abeta) plaques and the intracellular formation of neurofibrillary tangles (NFTs) in the cerebral cortex. Tau abnormalities are commonly observed in many neurodegenerative diseases including AD, Parkinson's disease, and Pick's disease. Interestingly, tau-mediated formation of NFTs in AD brains shows better correlation with cognitive impairment than Abeta plaque accumulation; pathological tau alone is sufficient to elicit frontotemporal dementia, but it does not cause AD...
September 20, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28923401/pharmacological-blockade-of-cholesterol-trafficking-by-cepharanthine-in-endothelial-cells-suppresses-angiogenesis-and-tumor-growth
#18
Junfang Lyu, Eun Ju Yang, Sarah A Head, Nana Ai, Baoyuan Zhang, Changjie Wu, Ruo-Jing Li, Yifan Liu, Chen Yang, Yongjun Dang, Ho Jeong Kwon, Wei Ge, Jun O Liu, Joong Sup Shim
Cholesterol is an important modulator of membrane protein function and signaling in endothelial cells, thus making it an emerging target for anti-angiogenic agents. In this study, we employed a phenotypic screen that detects intracellular cholesterol distribution in endothelial cells (HUVEC) and identified 13 existing drugs as cholesterol trafficking inhibitors. Cepharanthine, an approved drug for anti-inflammatory and cancer management use, was amongst the candidates, which was selected for in-depth mechanistic studies to link cholesterol trafficking and angiogenesis...
November 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28918065/the-role-of-epigenetics-in-lysosomal-storage-disorders-uncharted-territory
#19
REVIEW
Shahzeb Hassan, Ellen Sidransky, Nahid Tayebi
The study of the contribution of epigenetic mechanisms, including DNA methylation, histone modifications, and microRNAs, to human disease has enhanced our understanding of different cellular processes and diseased states, as well as the effect of environmental factors on phenotypic outcomes. Epigenetic studies may be particularly relevant in evaluating the clinical heterogeneity observed in monogenic disorders. The lysosomal storage disorders are Mendelian disorders characterized by a wide spectrum of associated phenotypes, ranging from neonatal presentations to symptoms that develop in late adulthood...
August 1, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28916146/chinese-sacbrood-virus-infection-in-asian-honey-bees-apis-cerana-cerana-and-host-immune-responses-to-the-virus-infection
#20
Liu Shan, Wang Liuhao, Guo Jun, Tang Yujie, Chen Yanping, Wu Jie, Li Jilian
Chinese Sacbrood virus (CSBV) is a positive-stranded RNAvirus that infects both the European honey bee (Apis mellifera) and the Asian honey bee (A. cerana). However, CSBV has much more devastating effects on Asian honey bees than on European honey bees, posing a serious threat to the agricultural and natural ecosystems that rely on A. cerana for pollination service. Using quantitative RT-PCR method, we conducted studies to examine the CSBV infection in Asian honey bee colonies and immune responses of individual bees in response to CSBV infection...
September 12, 2017: Journal of Invertebrate Pathology
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