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https://www.readbyqxmd.com/read/28339959/increased-evoked-potentials-and-behavioral-indices-in-response-to-pain-among-individuals-with-intellectual-disability
#1
Tali Benromano, Chaim G Pick, Yelena Granovsky, Ruth Defrin
Objective.:  Previous studies on the sensitivity and reactivity to pain of individuals with intellectual disability (ID) are inconsistent. The inconsistency may result from the reliance on self-reports and facial expressions of pain that are subject to internal and external biases. The aim was therefore to evaluate the reactivity to pain of individuals with ID by recording pain-evoked potentials (EPs), here for the first time, and testing their association with behavioral pain indices...
March 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339382/menopausal-symptom-relief-and-side-effects-experienced-by-women-using-compounded-bioidentical-hormone-replacement-therapy-and-synthetic-conjugated-equine-estrogen-and-or-progestin-hormone-replacement-therapy-part-2
#2
Laura J Deleruyelle
The use of compounded bioidentical hormone replacement therapy by menopausal women has become a popular alternative to traditional synthetic conjugated equine estrogen and progestin hormone replacement therapy due to safety concerns raised by recent studies. However, due to the lack of randomized, large-scale trials to evaluate the efficacy and side-effect profile of compounded bioidentical hormone replacement therapy many healthcare providers are reluctant to prescribe such therapy. The purpose of this study was to compare women's menopausal symptom relief and side effects experienced when using compounded bioidentical hormone replacement therapy and traditional hormone replacement therapy...
November 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28339370/menopausal-symptom-relief-and-side-effects-experienced-by-women-using-bioidentical-hormone-replacement-therapy-and-synthetic-conjugated-equine-estrogen-and-or-progestin-hormone-replacement-therapy-part-1
#3
Laura J Deleruyelle
The use of compounded bioidentical hormone replacement therapy by menopausal women has become a popular alternative to traditional synthetic conjugated equine estrogen and progestin hormone replacement therapy due to safety concerns raised by recent studies. However, due to the lack of randomized, large-scale trials to evaluate the efficacy and side-effect profile of compounded bioidentical hormone replacement therapy many healthcare providers are reluctant to prescribe such therapy. The purpose of this study was to compare women's menopausal symptom relief and side effects experienced when using compounded bioidentical hormone replacement therapy and traditional hormone replacement therapy...
September 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28338313/ultimate-control-of-rate-dependent-adhesion-for-reversible-transfer-process-via-thin-elastomeric-layer
#4
Chan Kim, Min-Ah Yoon, Bongkyun Jang, Jae-Hyun Kim, Hak-Joo Lee, Kwang-Seop Kim
Adhesion between a stamp with an elastomeric layer and various devices or substrates is crucial to successfully fabricate flexible electronics using a transfer process. Although various transfer processes using stamps with different adhesion strengths have been suggested, the controllable range of adhesion is still limited to a narrow range. To precisely transfer devices onto selected substrates, however, the difference in adhesion between the picking and placing processes should be large enough to achieve a high yield...
March 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28337429/investigating-cardiac-motion-patterns-using-synthetic-high-resolution-3d-cardiovascular-magnetic-resonance-images-and-statistical-shape-analysis
#5
Benedetta Biffi, Jan L Bruse, Maria A Zuluaga, Hopewell N Ntsinjana, Andrew M Taylor, Silvia Schievano
Diagnosis of ventricular dysfunction in congenital heart disease is more and more based on medical imaging, which allows investigation of abnormal cardiac morphology and correlated abnormal function. Although analysis of 2D images represents the clinical standard, novel tools performing automatic processing of 3D images are becoming available, providing more detailed and comprehensive information than simple 2D morphometry. Among these, statistical shape analysis (SSA) allows a consistent and quantitative description of a population of complex shapes, as a way to detect novel biomarkers, ultimately improving diagnosis and pathology understanding...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28336668/lysosomal-cholesterol-activates-mtorc1-via-an-slc38a9-niemann-pick-c1-signaling-complex
#6
Brian M Castellano, Ashley M Thelen, Ofer Moldavski, McKenna Feltes, Reini E N van der Welle, Laurel Mydock-McGrane, Xuntian Jiang, Robert J van Eijkeren, Oliver B Davis, Sharon M Louie, Rushika M Perera, Douglas F Covey, Daniel K Nomura, Daniel S Ory, Roberto Zoncu
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that becomes activated at the lysosome in response to nutrient cues. Here, we identify cholesterol, an essential building block for cellular growth, as a nutrient input that drives mTORC1 recruitment and activation at the lysosomal surface. The lysosomal transmembrane protein, SLC38A9, is required for mTORC1 activation by cholesterol through conserved cholesterol-responsive motifs. Moreover, SLC38A9 enables mTORC1 activation by cholesterol independently from its arginine-sensing function...
March 24, 2017: Science
https://www.readbyqxmd.com/read/28335886/neoscope-a-randomised-phase-ii-study-of-induction-chemotherapy-followed-by-oxaliplatin-capecitabine-or-carboplatin-paclitaxel-based-pre-operative-chemoradiation-for-resectable-oesophageal-adenocarcinoma
#7
Somnath Mukherjee, Christopher Nicholas Hurt, Sarah Gwynne, David Sebag-Montefiore, Ganesh Radhakrishna, Simon Gollins, Maria Hawkins, Heike I Grabsch, Gareth Jones, Stephen Falk, Ricky Sharma, Andrew Bateman, Rajarshi Roy, Ruby Ray, Jo Canham, Gareth Griffiths, Tim Maughan, Tom Crosby
BACKGROUND: Oxaliplatin-capecitabine (OxCap) and carboplatin-paclitaxel (CarPac) based neo-adjuvant chemoradiotherapy (nCRT) have shown promising activity in localised, resectable oesophageal cancer. PATIENTS AND METHODS: A non-blinded, randomised (1:1 via a centralised computer system), 'pick a winner' phase II trial. Patients with resectable oesophageal adenocarcinoma ≥ cT3 and/or ≥ cN1 were randomised to OxCapRT (oxaliplatin 85 mg/m(2) day 1, 15, 29; capecitabine 625 mg/m(2) bd on days of radiotherapy) or CarPacRT (carboplatin AUC2; paclitaxel 50 mg/m(2) day 1, 8, 15, 22, 29)...
March 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28333776/transcanal-endoscopic-ear-surgery-for-middle-ear-cholesteatoma
#8
Eran Glikson, Ruth Yousovich, Jobran Mansour, Michael Wolf, Lela Migirov, Yisgav Shapira
OBJECTIVE: To evaluate the clinical parameters, outcomes, and complications of transcanal endoscopic ear surgeries for middle ear cholesteatoma. STUDY DESIGN: Retrospective study. SETTING: Tertiary university-affiliated medical center. PATIENTS: Adult patients (age >18) who underwent transcanal endoscopic ear surgeries for cholesteatoma, between March 2009 and March 2015. INTERVENTION: Transcanal endoscopic surgery was indicated when the cholesteatoma did not extend posterior to the anterior limb of the lateral semicircular canal...
March 22, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28333405/use-of-nanofractional-radiofrequency-for-the-treatment-of-acne-scars-in-indian-skin
#9
Apratim Goel, Vallari Gatne
BACKGROUND: Pitted acne scars of all types remain notoriously challenging to treat with no satisfactory treatment modality, particularly true for darker Fitzpatrick skin types such as Indian skin. AIM: Nanofractional radiofrequency has been shown to be an effective treatment modality for the cosmetic improvement of acne scars. METHODS: Twenty healthy male and female Indian patients aged 16-60 years with Fitzpatrick skin types IV-V and moderate-to-severe acne scar lesions received 1-3 treatments with a nanofractional radiofrequency device (Venus Viva) at baseline and at 3- to 6 week intervals and were evaluated with photographs at each treatment visit and up to 6 months after the final treatment session...
March 23, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28332184/primary-cilium-alterations-and-expression-changes-of-patched1-proteins-in-niemann-pick-type-c-disease
#10
Patrizia Formichi, Carla Battisti, Maria Margherita De Santi, Raffaella Guazzo, Sergio Antonio Tripodi, Elena Radi, Benedetta Rossi, Ermelinda Tarquini, Antonio Federico
Niemann-Pick type C disease (NPC) is a disorder characterized by abnormal intracellular accumulation of unesterified cholesterol and glycolipids. Two distinct disease-causing genes have been isolated, NPC1 and NPC2. The NPC1 protein is involved in the sorting and recycling of cholesterol and glycosphingolipids in the late endosomal/lysosomal system. It has extensive homology with the Patched 1 (Ptc1) receptor, a transmembrane protein localized in the primary cilium and involved in the Hedgehog signaling (Shh) pathway...
March 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28332104/exhaustive-mathematical-analysis-of-simple-clinical-measurements-for-childhood-pneumonia-diagnosis
#11
Keegan Kosasih, Udantha Abeyratne
BACKGROUND: Pneumonia is the leading cause of mortality for children below 5 years of age. The majority of these occur in poor countries with limited access to diagnosis. The World Health Organization (WHO) criterion for pneumonia is the de facto method for diagnosis. It is designed targeting a high sensitivity and uses easy to measure parameters. The WHO criterion has poor specificity. METHODS: We propose a method using common measurements (including the WHO parameters) to diagnose pneumonia at high sensitivity and specificity...
March 22, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28329414/a-protocol-for-the-development-of-a-critical-thinking-assessment-tool-for-nurses-using-a-delphi-technique
#12
Elisabeth Jacob, Christine Duffield, Darren Jacob
AIM: The aim of this study is to develop an assessment tool to measure the critical thinking ability of nurses. BACKGROUND: As an increasing number of complex patients are admitted to hospitals, the importance of nurses recognising changes in health status and picking up on deterioration is more important. To detect early signs of complication requires critical thinking skills. Registered nurses are expected to commence their clinical careers with the necessary critical thinking skills to ensure safe nursing practice...
March 22, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28327092/metax-a-flexible-and-comprehensive-software-for-processing-metabolomics-data
#13
Bo Wen, Zhanlong Mei, Chunwei Zeng, Siqi Liu
BACKGROUND: Non-targeted metabolomics based on mass spectrometry enables high-throughput profiling of the metabolites in a biological sample. The large amount of data generated from mass spectrometry requires intensive computational processing for annotation of mass spectra and identification of metabolites. Computational analysis tools that are fully integrated with multiple functions and are easily operated by users who lack extensive knowledge in programing are needed in this research field...
March 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28325559/new-evidence-of-the-relative-protective-effects-of-neurodegenerative-diseases-and-cancer-against-each-other
#14
A Robles Bayón, F Gude Sampedro
BACKGROUND: Cancer and degenerative diseases share some pathogenic mechanisms which act in opposition to one another to produce either uncontrolled cell proliferation or cell death. According to several studies, patients with Alzheimer disease have a lower risk of neoplasia, and vice versa. This study describes the prevalence of tumours (active or successfully treated) in a series of patients with and without a dementing degenerative disease treated at a cognitive neurology unit. PATIENTS AND METHOD: We analysed the frequency and topography of tumours and the presence or absence of a neurodegenerative disease in a group of 1,164 patients...
March 18, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28325386/-identifying-a-child-in-danger-during-a-consultation-in-the-emergency-department
#15
REVIEW
Patricia Vasseur
Child abuse is a public health issue. Many abused children present physical injuries which could be picked up in emergency departments. Caregivers must therefore be particularly vigilant from the moment the child arrives. Some reluctance to report potential abuse, notably due to denial or to being overly cautious can place the child in irreversible danger.
March 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28323685/ipsilateral-tremor-like-grasp-reaction-in-a-patient-with-ischemic-stroke
#16
Yuichiro Inatomi, Makoto Nakajima, Toshiro Yonehara, Yukio Ando
Reports of involuntary ipsilateral movements after a stroke are rare, and none have described a patient with both an instinctive grasp reaction and tremor-like movement ipsilateral to the acute stroke lesion. We here report such a patient. A 76-year-old right-handed woman with a past history of left thalamic hemorrhage developed left hemiparesis, an instinctive grasp reaction, and a peculiar involuntary movement of her right arm. This involuntary movement was stereotyped and sometimes rhythmical, with a groping or picking-like action...
March 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28322747/quantitation-of-the-rates-of-hepatic-and-intestinal-cholesterol-synthesis-in-lysosomal-acid-lipase-deficient-mice-before-and-during-treatment-with-ezetimibe
#17
Jen-Chieh Chuang, Adam M Lopez, Stephen D Turley
Esterified cholesterol (EC) and triglycerides, contained within lipoproteins taken up by cells, are hydrolysed by lysosomal acid lipase (LAL) in the late endosomal/lysosomal (E/L) compartment. The resulting unesterified cholesterol (UC) is transported via Niemann-Pick type C2 and C1 into the cytosolic compartment where it enters a putative pool of metabolically active cholesterol that is utilized in accordance with cellular needs. Loss-of-function mutations in LIPA, the gene encoding LAL, result in dramatic increases in tissue concentrations of EC, a hallmark feature of Wolman Disease and Cholesteryl Ester Storage Disease (CESD)...
March 16, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28322308/optimising-reliability-of-mouse-performance-in-behavioural-testing-the-major-role-of-non-aversive-handling
#18
Kelly Gouveia, Jane L Hurst
Handling laboratory animals during test procedures is an important source of stress that may impair reliability of test responses. Picking up mice by the tail is aversive, stimulating stress and anxiety. Responses among anxious animals can be confounded further by neophobia towards novel test environments and avoidance of test stimuli in open areas. However, handling stress can be reduced substantially by using a handling tunnel, or cupping mice without restraint on the open hand. Here we establish whether non-aversive handling, brief prior familiarisation with the test arena and alternative stimulus placement could significantly improve performance of mice in behavioural tests...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321440/neuronify-an-educational-simulator-for-neural-circuits
#19
Svenn-Arne Dragly, Milad Hobbi Mobarhan, Andreas Våvang Solbrå, Simen Tennøe, Anders Hafreager, Anders Malthe-Sørenssen, Marianne Fyhn, Torkel Hafting, Gaute T Einevoll
Educational software (apps) can improve science education by providing an interactive way of learning about complicated topics that are hard to explain with text and static illustrations. However, few educational apps are available for simulation of neural networks. Here, we describe an educational app, Neuronify, allowing the user to easily create and explore neural networks in a plug-and-play simulation environment. The user can pick network elements with adjustable parameters from a menu, i.e., synaptically connected neurons modelled as integrate-and-fire neurons and various stimulators (current sources, spike generators, visual, and touch) and recording devices (voltmeter, spike detector, and loudspeaker)...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28320351/the-prevalence-and-factors-associated-for-anti-tuberculosis-treatment-non-adherence-among-pulmonary-tuberculosis-patients-in-public-health-care-facilities-in-south-ethiopia-a-cross-sectional-study
#20
Tadele Teshome Woimo, Wondwossen Kassahun Yimer, Temesgen Bati, Hailay Abrha Gesesew
BACKGROUND: Evidence exists pointing out how non-adherence to treatment remains a major hurdle to efficient tuberculosis control in developing countries. Many tuberculosis (Tb) patients do not complete their six-month course of anti-tuberculosis medications and are not aware of the importance of sputum re-examinations, thereby putting themselves at risk of developing multidrug-resistant and extensively drug-resistant forms of tuberculosis and relapse. However, there is a dearth of publications about non-adherence towards anti-Tb medication in these settings...
March 20, 2017: BMC Public Health
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