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https://www.readbyqxmd.com/read/29691902/3d-printed-functional-and-biological-materials-on-moving-freeform-surfaces
#1
Zhijie Zhu, Shuang-Zhuang Guo, Tessa Hirdler, Cindy Eide, Xiaoxiao Fan, Jakub Tolar, Michael C McAlpine
Conventional 3D printing technologies typically rely on open-loop, calibrate-then-print operation procedures. An alternative approach is adaptive 3D printing, which is a closed-loop method that combines real-time feedback control and direct ink writing of functional materials in order to fabricate devices on moving freeform surfaces. Here, it is demonstrated that the changes of states in the 3D printing workspace in terms of the geometries and motions of target surfaces can be perceived by an integrated robotic system aided by computer vision...
April 25, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29691198/direct-observation-of-medicaid-beneficiary-attempts-to-fill-prescriptions-for-nicotine-replacement-medications
#2
Kimber P Richter, Elena Shergina, Amanda Grodie, Justin K Massey, Edward F Ellerbeck, Amanda Applegate, Babalola Faseru
OBJECTIVES: Although many states have expanded Medicaid coverage of cessation medications, utilization remains low. Anecdotal reports suggest that beneficiaries are at times denied coverage of cessation medications at the pharmacy counter. We conducted an observational community-wide case study of Medicaid beneficiary attempts to fill over-the-counter nicotine replacement therapy at pharmacies. METHODS: We recruited tobacco-using beneficiaries from a Federally Qualified Health Center, whose providers wrote paper prescriptions for nicotine patches...
April 21, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29691055/multiwall-carbon-nanotube-zirconium-oxide-nanocomposite-hollow-fiber-solid-phase-microextraction-for-determination-of-polyaromatic-hydrocarbons-in-water-coffee-and-tea-samples
#3
Mahnaz Nozohour Yazdi, Yadollah Yamini, Hamid Asiabi
The purpose of this study was to evaluate the application of hollow fiber solid-phase microextraction (HF-SPME) followed by HPLC-UV to determine the ultra-trace amounts of polycyclic aromatic hydrocarbons (PAHs) as model analytes in complex coffee and tea samples. HF-SPME can be effectively used as an alternative to the direct immersion SPME (DI-SPME) method in complex matrices. The DI-SPME method suffers from serious limitation in dirty and complicated matrices with low sample clean-up, while the HF-SPME method has high clean-up and selectivity due to the high porosity of hollow fiber that can pick out analyte from complicated matrices...
April 17, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29690360/the-larva-and-pupa-of-potamyia-flavata-banks-1934-trichoptera-hydropsychidae-description-life-cycle-and-notes-on-its-biology
#4
Witwisitpong Maneechan, Phassawat Kruttha, Taeng On Prommi
The immature and adult stages of Potamyia flavata Banks 1934 were sampled in seven sampling sites in streams of western Thailand. The samples were collected in February, May, and December 2015 using hand picking. A total of 2,133 individuals of larvae were collected. The larva and pupa of Po. flavata are described and illustrated. Larvae have five instars. The head capsule width of the first to the fifth instar larvae were 0.20-0.29, 0.30-0.39, 0.40-0.59, 0.60-0.79, and 0.80-1.15 mm, respectively. Gut content analysis revealed that larvae are omnivorous filterers...
March 14, 2018: Zootaxa
https://www.readbyqxmd.com/read/29689209/collective-behaviour-physiology-determines-position
#5
Jens Krause, Frank Seebacher
An animal's position within a group affects feeding - front positions generally offer richer pickings. However, a new study shows that position can be influenced by feeding because big meals reduce scope for locomotion.
April 23, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29687233/starting-or-finishing-sooner-sequencing-preferences-in-object-transfer-tasks
#6
Lisa R Fournier, Alexandra M Stubblefield, Brian P Dyre, David A Rosenbaum
When tasks are performed, other tasks are postponed, at least implicitly. Little is known about how task sequencing is determined. We examined task sequencing in object transfer tasks for which either task could easily or logically come before the other. The task was to transfer ping pong balls from two buckets into a bowl. To perform the task, participants walked down a corridor, picked up one of two buckets (their choice), carried it to the end of the corridor, transferred the balls from the bucket into a bowl, carried the bucket back to the start position, and then did the same with the other remaining bucket...
April 23, 2018: Psychological Research
https://www.readbyqxmd.com/read/29686301/endocannabinoids-in-caenorhabditis-elegans-are-essential-for-the-mobilization-of-cholesterol-from-internal-reserves
#7
Celina Galles, Gastón M Prez, Sider Penkov, Sebastian Boland, Exequiel O J Porta, Silvia G Altabe, Guillermo R Labadie, Ulrike Schmidt, Hans-Joachim Knölker, Teymuras V Kurzchalia, Diego de Mendoza
Proper cholesterol transport is crucial for the functionality of cells. In C. elegans, certain cholesterol derivatives called dafachronic acids (DAs) govern the entry into diapause. In their absence, worms form a developmentally arrested dauer larva. Thus, cholesterol transport to appropriate places for DA biosynthesis warrants the reproductive growth. Recently, we discovered a novel class of glycosphingolipids, PEGCs, required for cholesterol mobilization/transport from internal storage pools. Here, we identify other components involved in this process...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29686101/coupling-maldi-tof-mass-spectrometry-protein-and-specialized-metabolite-analyses-to-rapidly-discriminate-bacterial-function
#8
Chase M Clark, Maria S Costa, Laura M Sanchez, Brian T Murphy
For decades, researchers have lacked the ability to rapidly correlate microbial identity with bacterial metabolism. Since specialized metabolites are critical to bacterial function and survival in the environment, we designed a data acquisition and bioinformatics technique (IDBac) that utilizes in situ matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) to analyze protein and specialized metabolite spectra recorded from single bacterial colonies picked from agar plates...
April 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29686047/neural-representations-of-sensorimotor-memory-and-digit-position-based-load-force-adjustments-before-the-onset-of-dexterous-object-manipulation
#9
Michelle Marneweck, Deborah A Barany, Marco Santello, Scott T Grafton
Anticipatory load forces for dexterous object manipulation in humans are modulated based on visual object properties cues, sensorimotor memories of previous experiences with the object, and, when digit positioning varies from trial-to-trial, the integrating of this sensed variability with force modulation. Studies of the neural representations encoding these anticipatory mechanisms have not considered these mechanisms separately from each other or from feedback mechanisms emerging after lift onset. Representational similarity analyses of fMRI data were used to identify neural representations of sensorimotor memories and the sensing and integration of digit position...
April 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29685064/neuroanatomical-correlates-of-impulsive-action-in-excoriation-skin-picking-disorder
#10
Austin W Blum, Samuel R Chamberlain, Michael D Harries, Brian L Odlaug, Sarah A Redden, Jon E Grant
Excoriation (skin-picking) disorder (SPD) has similarities to obsessive-compulsive disorder (OCD) and is included within the obsessive-compulsive and related disorders (OCRD) diagnostic class in DSM-5. Separate neuroimaging and neurocognitive studies suggest that people affected by SPD find it difficult to inhibit dominant motor responses due to a failure of "top-down" control mechanisms. No study has examined the neural correlates of SPD in participants with varying degrees of impulsive motor behavior...
April 24, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29682683/using-matrix-frame-to-present-road-traffic-injury-pattern
#11
Chien-Hsing Wang, Wan-Hua Hsieh, Fu-Wen Liang, Tsung-Hsueh Lu
BACKGROUND: Although many epidemiological studies have presented road traffic injuries (RTIs) according to the victim's mode of transport, very few have mentioned the mode of transport of the victim's counterparts. We sought to use matrix frame to present the pattern of RTIs based on the International Classification of Diseases, Tenth Revision (ICD-10) codes. METHODS: Patients admitted to Hualien Tzu Chi Hospital, Taiwan, for RTIs from January 1, 2013 to December 31, 2016 were included...
April 23, 2018: Injury Epidemiology
https://www.readbyqxmd.com/read/29682664/liquid-marble-coalescence-via-vertical-collision
#12
Jing Jin, Chin Hong Ooi, Dzung Viet Dao, Nam-Trung Nguyen
The coalescence process of liquid marbles is vital to their promising roles as reactors or mixers in digital microfluidics. However, the underlying mechanisms and critical conditions of liquid marble coalescence are not well understood. This paper studies the coalescence process of two equally-sized liquid marbles via vertical collision aided by dielectrophoretic handling. A liquid marble was picked up using the dielectrophoretic force and then dropped vertically onto another liquid marble resting on a hydrophobic powder bed...
April 23, 2018: Soft Matter
https://www.readbyqxmd.com/read/29679959/uptake-of-methanol-on-mixed-hno-3-h-2-o-clusters-an-absolute-pickup-cross-section
#13
A Pysanenko, J Lengyel, M Fárník
The uptake of atmospheric oxidized organics on acid clusters is relevant for atmospheric new particle formation. We investigate the pickup of methanol (CH3 OH) on mixed nitric acid-water clusters (HNO3 )M (H2 O)N by a combination of mass spectrometry and cluster velocity measurements in a molecular beam. The mass spectra of the mixed clusters exhibit (HNO3 )m (H2 O)n H+ series with m = 0-3 and n = 0-12. In addition, CH3 OH·(HNO3 )m (H2 O)n H+ series with very similar patterns appear in the spectra after the methanol pickup...
April 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29678888/bovine-spastic-syndrome-a-review
#14
REVIEW
Victoria Goeckmann, Sophie Rothammer, Ivica Medugorac
Bovine spastic syndrome (BSS) was described for the first time in 1941. The disease occurs in various-maybe even all-cattle breeds and is a chronic-progressive neuromuscular disorder that commonly affects cattle of at least three years of age. Typical clinical signs of the disease are clonic-tonic cramps of the hindlimbs that occur in attacks. Since BSS does not recover, affected animals can only be treated symptomatically by improving welfare conditions and management factors, or with physical therapy or drugs...
April 20, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29676235/current-and-promising-therapies-in-autosomal-recessive-ataxias
#15
Vincent Picher-Martel, Nicolas Dupre
BACKGROUND & OBJECTIVE: Ataxia is clinically characterized by unsteady gait and imbalance. Cerebellar disorders may arise from many causes such as metabolic diseases, stroke or genetic mutations. The genetic causes are classified by mode of inheritance and include autosomal dominant, X-linked and autosomal recessive ataxias. Many years have passed since the description of Friedreich's ataxia, the most common autosomal recessive ataxia, and mutations in many other genes have now been described...
April 18, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29675608/gun-theft-and-crime
#16
Philip J Cook
Some law enforcement officials and other observers have asserted that theft is the primary source of guns to crime. In fact, the role of theft in supplying the guns used in robbery, assault, and murder is unknown, and current evidence provides little guidance about whether an effective program to reduce gun theft would reduce gun violence. The current article analyzes publicly available national data on gun theft together with a unique data set for Chicago. The results tend to support a conclusion that stolen guns play only a minor role in crime...
April 19, 2018: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/29675214/controllable-extension-of-hairpin-structured-flaps-to-allow-low-background-cascade-invasive-reaction-for-a-sensitive-dna-logic-sensor-for-mutation-detection
#17
Yun-Long Liu, Hai-Ping Wu, Qiang Zhou, Qin-Xin Song, Jian-Zhong Rui, Xiao-Xiang Guan, Guo-Hua Zhou, Bing-Jie Zou
A DNA logic sensor was constructed for gene mutation analysis based on a novel signal amplification cascade by controllably extending a hairpin-structured flap to bridge two invasive reactions. The detection limit was as low as 0.07 fM, and the analytical specificity is high enough to unambiguously pick up 0.02% mutants from a large amount of wild-type DNA. Gene mutations related to the personalized medicine of gefitinib, a typical tyrosine kinase inhibitor, were analyzed by the DNA logic sensor with only a 15 minute response time...
February 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674797/adverse-drug-reactions-at-adverse-drug-reaction-monitoring-center-in-raipur-analysis-of-spontaneous-reports-during-1-year
#18
Preeti Singh, Manju Agrawal, Rajesh Hishikar, Usha Joshi, Basant Maheshwari, Ajay Halwai
BACKGROUND: India is a developing country and adverse drug reactions (ADRs) influence most of the diseases in our population, and monitoring is required due to the paucity of ADRs. The present study was done to analyze the ADRs at the ADR monitoring center (AMC) of tertiary care hospital in Raipur during 1 year. MATERIALS AND METHODS: Study of ADR monitoring of outpatient and inpatient was a prospective and observational study carried out between September 2015 and August 2016...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674167/neuraminidase-as-an-influenza-vaccine-antigen-a-low-hanging-fruit-ready-for-picking-to-improve-vaccine-effectiveness
#19
REVIEW
Maryna C Eichelberger, David M Morens, Jeffery K Taubenberger
Neuraminidase (NA) plays an essential role in influenza virus replication, facilitating multicycle infection predominantly by releasing virions from infected cells. NA-inhibiting antibodies provide resistance to disease and NA-specific antibodies contribute to vaccine efficacy. The primary reason NA vaccine content and immunogenicity was not routinely measured in the past, was the lack of suitable assays to quantify NA and NA-specific antibodies. These are now available and with recent appreciation of its contribution to immunity, NA content of seasonal and pandemic vaccines is being considered...
April 16, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29672980/using-disruptive-insertional-mutagenesis-to-identify-the-in-situ-structure-function-landscape-of-the-shigella-translocator-protein-ipab
#20
Michael L Barta, Shoichi Tachiyama, Meenakumari Muthuramalingam, Olivia Arizmendi, Cecilia E Villanueva, Kasra X Ramyar, Brian V Geisbrecht, Scott Lovell, Kevin P Battaile, Wendy L Picking, William D Picking
Bacterial type III secretion systems (T3SS) are used to inject proteins into mammalian cells to subvert cellular functions. The Shigella T3SS apparatus (T3SA) is comprised of a basal body, cytoplasmic sorting platform and exposed needle with needle "tip complex" (TC). TC maturation occurs when the translocator protein IpaB is recruited to the needle tip where both IpaD and IpaB control secretion induction. IpaB insertion into the host membrane is the first step of translocon pore formation and secretion induction...
April 19, 2018: Protein Science: a Publication of the Protein Society
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