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https://www.readbyqxmd.com/read/29228030/logistic-regression-analysis-of-conventional-ultrasonography-strain-elastosonography-and-contrast-enhanced-ultrasound-characteristics-for-the-differentiation-of-benign-and-malignant-thyroid-nodules
#1
Tiantian Pang, Leidan Huang, Yingyuan Deng, Tianfu Wang, Siping Chen, Xuehao Gong, Weixiang Liu
The aim of the study is to screen the significant sonographic features by logistic regression analysis and fit a model to diagnose thyroid nodules. A total of 525 pathological thyroid nodules were retrospectively analyzed. All the nodules underwent conventional ultrasonography (US), strain elastosonography (SE), and contrast -enhanced ultrasound (CEUS). Those nodules' 12 suspicious sonographic features were used to assess thyroid nodules. The significant features of diagnosing thyroid nodules were picked out by logistic regression analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29227331/unravelling-new-pathways-of-sterol-metabolism-lessons-learned-from-in-born-errors-and-cancer
#2
Yuqin Wang, William J Griffiths
PURPOSE OF REVIEW: To update researchers of recently discovered metabolites of cholesterol and of its precursors and to suggest relevant metabolic pathways. RECENT FINDINGS: Patients suffering from inborn errors of sterol biosynthesis, transport and metabolism display unusual metabolic pathways, which may be major routes in the diseased state but minor in the healthy individual. Although quantitatively minor, these pathways may still be important in healthy individuals...
December 11, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29226369/safety-of-biologics-in-psoriasis
#3
REVIEW
Masahiro Kamata, Yayoi Tada
The advent of biologics brought a paradigm shift in ways to treat psoriatic patients because they have dramatic efficacy. At the same time, safety concerns about biologics have been raised. In this paper, we focus on the safety profile of biologics for psoriasis. As of 2017, six biologics are available in Japan. Two tumor necrosis factor-α inhibitors; infliximab and adalimumab, one anti-interleukin (IL)-12/23p40 antibody; ustekinumab, and IL-17 inhibitors; secukinumab, ixekizumab and brodalumab. Secukinumab and ixekizumab are anti-IL-17A antibodies...
December 10, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29225959/effect-of-removing-the-barrier-of-transportation-costs-on-surgical-utilisation-in-guinea-madagascar-and-the-republic-of-congo
#4
Mark G Shrime, Mirjam Hamer, Swagoto Mukhopadhyay, Lauren M Kunz, Nathan H Claus, Kirsten Randall, Joannita H Jean-Baptiste, Pierre H Maevatombo, Melissa P S Toh, Jasmin R Biddell, Ria Bos, Michelle White
Background: 81 million people face impoverishment from surgical costs every year. The majority of this impoverishment is attributable to the non-medical costs of care-for transportation, for food and for lodging. Of these, transportation is the largest, but because it is not viewed as an actual medical cost, it is frequently unaddressed. This paper examines the effect on surgical utilisation of paying for transportation. Methods: A hierarchical logistic regression was performed on 2692 patients presenting for surgical care to a non-governmental organisation operating in the Republic of the Congo, Guinea and Madagascar...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29225015/symptomatic-focal-knee-chondral-injuries-in-national-football-league-combine-players-are-associated-with-poorer-performance-and-less-volume-of-play
#5
Matthew T Provencher, Jorge Chahla, Mark E Cinque, George Sanchez, Nicholas I Kennedy, Daniel B Haber, Ashley J Tisosky, Brendin R Beaulieu-Jones, Mark D Price, James M Whalen, Gilbert Moatshe, Robert F LaPrade
PURPOSE: To (1) describe the magnetic resonance imaging (MRI) characteristics of knee chondral injuries identified at the National Football League (NFL) Combine and (2) assess in-game performance of prospective NFL players with previously untreated knee chondral injuries and compare it with matched controls. METHODS: All players with knee chondral injuries identified at the NFL Combine (2009-2015) were retrospectively reviewed. Players with prior knee surgery were excluded...
December 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29224156/multiplexed-and-sensitive-dna-methylation-testing-using-methylation-sensitive-restriction-enzymes-msre-qpcr
#6
Gabriel Beikircher, Walter Pulverer, Manuela Hofner, Christa Noehammer, Andreas Weinhaeusel
DNA methylation is a chemically stable key-player in epigenetics. In the vertebrate genome the 5-methyl cytosine (5mC) has been found almost exclusively in the CpG dinucleotide context. CpG dinucleotides are enriched in CpG islands very frequently located within or close to gene promoters. Analyses of DNA methylation changes in human diagnostics have been conducted classically using methylation-sensitive restriction enzymes (MSRE). Since the discovery of bisulfite conversion-based sequencing and PCR assays, MSRE-based PCR assays have been less frequently used, although especially in the field of cancer epigenetics MSRE-based genome-wide discovery and targeted screening applications have been and are still performed successfully...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29223359/in-niemann-pick-c1-mouse-models-glial-only-expression-of-the-normal-gene-extends-survival-much-further-than-do-changes-in-genetic-background-or-treatment-with-hydroxypropyl-beta-cyclodextrin
#7
Craig A Marshall, Dawn E Watkins-Chow, Giampiero Palladino, Gail Deutsch, Keshav Chandran, William J Pavan, Robert P Erickson
The Npc1nmf164 allele of Npc1 provides a mouse model for Niemann-Pick disease type C1 (NPC1), a genetic disease known to have a widely variable phenotype. The transfer of the Npc1nmf164 mutation from the C57BL/6J inbred strain to the BALB/cJ inbred strain increased the mean lifespan from 117.8days to 153.1days, confirming that the severity of the NPC1 phenotype is strongly influenced by genetic background. The transfer of another Npc1 allele, Npc1nih, to this background also extended survival of the homozygotes indicating that the modifying effect of BALB/cJ is not limited to a single allele of Npc1...
December 6, 2017: Gene
https://www.readbyqxmd.com/read/29219458/detection-of-microwave-transitions-between-ortho-and-para-states-in-a-free-isolated-molecule
#8
Hideto Kanamori, Zeinab T Dehghani, Asao Mizoguchi, Yasuki Endo
Microwave transitions between the ortho and para states of the S_{2}Cl_{2} molecule in a free isolated condition are observed for the first time. In the theoretical treatment, we derive eigenfunctions of an effective Hamiltonian including the ortho-para interaction to calculate the intensities and frequencies of forbidden ortho-para transitions in the cm-wave region and pick up some promising candidates for the spectroscopic detection. In the experiment, transitions of the S_{2}Cl_{2} molecule under a supersonic jet condition are observed with a Fourier transform microwave spectrometer...
October 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29218847/potential-exposure-to-australian-bat-lyssavirus-is-unlikely-to-prevent-future-bat-handling-among-adults-in-south-east-queensland
#9
M K Young, S Banu, B J McCall, S Vlack, H Carroll, S Bennett, R Davison, D Francis
Despite ongoing public health messages about the risks associated with bat contact, the number of potential exposures to Australian bat lyssavirus (ABLV) due to intentional handling by members of the general public in Queensland has remained high. We sought to better understand the reasons for intentional handling among these members of the public who reported their potential exposure to inform future public health messages. We interviewed adults who resided in a defined geographic area in South East Queensland and notified potential exposure to ABLV due to intentional handling of bats by telephone between 1 January 2012 and 31 December 2013...
December 8, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29218843/potential-of-saprophage-diptera-to-acquire-culturable-livestock-associated-antibiotic-resistant-bacteria
#10
S M Russell, V A Chittick, D T Sangweme, E C Lampert
The increasing prevalence of antibiotic resistance among bacteria is one of the most intractable challenges in 21st-century public health. Dipterans that associate with livestock, livestock waste products and cadavers have the potential to acquire livestock-associated antibiotic-resistant bacteria (LA-ARB) and transmit them to humans. In this study, piglet cadavers were used to attract saprophage dipterans from the environment and those dipterans were sampled for the presence of LA-ARB. In the first trial, culturable microbes resistant to both aminoglycoside and β-lactam antibiotics were found in all cadavers and masses of dipteran larvae, and in three-quarters of adult dipterans...
December 8, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29218753/neuronal-responses-to-the-scratching-and-caressing-of-one-s-own-skin-in-patients-with-skin-picking-disorder
#11
Anne Schienle, Sonja Übel, Albert Wabnegger
Skin-picking disorder (SPD) is a common mental disorder. The predominant symptom involves the repeated scratching and picking of one's own skin. This behavior causes severe tissue damage (sores, scars, and infections), often leading to disfigurement. Besides physical injury, SPD is associated with clinically significant distress and impairment in important areas of functioning. The neurobiological mechanisms of SPD are still poorly understood. In this study, 30 SPD patients and 31 control participants (35 women, 26 men) with a mean age of 34 years were instructed to either scratch or gently stroke a small skin area on their arms during functional magnetic resonance imaging...
December 7, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29217709/bradford-c-berk-picking-good-questions
#12
Sandra J Ackerman
No abstract text is available yet for this article.
December 8, 2017: Circulation Research
https://www.readbyqxmd.com/read/29217520/alex-azar-critics-cry-revolving-door-as-trump-picks-pharma-executive-for-top-us-health-job
#13
Liz Seegert
No abstract text is available yet for this article.
December 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29216772/proteomic-cinderella-customized-analysis-of-bulky-ms-ms-data-in-one-night
#14
Olga Kiseleva, Ekaterina Poverennaya, Alexander Shargunov, Andrey Lisitsa
Proteomic challenges, stirred up by the advent of high-throughput technologies, produce large amount of MS data. Nowadays, the routine manual search does not satisfy the "speed" of modern science any longer. In our work, the necessity of single-thread analysis of bulky data emerged during interpretation of HepG2 proteome profiling results for proteoforms searching. We compared the contribution of each of the eight search engines (X!Tandem, MS-GF[Formula: see text], MS Amanda, MyriMatch, Comet, Tide, Andromeda, and OMSSA) integrated in an open-source graphical user interface SearchGUI ( http://searchgui...
November 13, 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/29216122/delay-line-coherent-pulse-stacking
#15
Henrik Tünnermann, Akira Shirakawa
Ultrafast fiber amplifiers are usually limited in terms of pulse energy and peak power due to fiber damage and nonlinearities. On the other hand, fiber amplifiers are very energy efficient. To take advantage of this efficiency, but still scale the pulse energy, coherent combining and pulse stacking have become the method of choice. Here we show how to directly and symmetrically stack up the pulses from an oscillator chain, using delay lines and phase preshaping of a 48 MHz, 1.5 μm master oscillator. This method avoids the need for high-power low-loss dumpers as in passive stack and dump cavities and, compared to divided pulse amplification (DPA), it eliminates the need for splitting pulses and pulse picking and, thus, optimally utilizes the available seed power...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29215752/familial-tauopathy-with-p364s-mapt-mutation-clinical-course-neuropathology-and-ultrastructure-of-neuronal-tau-inclusions
#16
Peter Štrafela, Jerica Pleško, Jožef Magdič, Blaž Koritnik, Andrej Zupan, Damjan Glavač, Mara Bresjanac, Mara Popović
AIMS: This report presents the clinical course, neuropathology and ultrastructure of neuronal tau inclusions of four Slovene relatives with P364S MAPT mutation. METHODS: The clinical history of three out of four P364S MAPT mutation carriers was taken. After formalin fixation, thorough sampling of the central nervous system was followed by paraffin embedding, H&E, Gallyas, Bielschowsky, and immunostaining with AT8, anti-3R, anti-4R tau, anti-Amyloid-β, anti-TDP43, and anti-alpha-synuclein antibodies...
December 7, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29214754/utility-of-conventional-culture-and-maldi-tof-ms-for-identification-of-microbial-communities-in-bronchoalveolar-lavage-fluid-in-comparison-with-the-gs-junior-next-generation-sequencing-system
#17
Ji Yeon Sung, Younjee Hwang, Mi Hwa Shin, Moo Suk Park, Sang Hoon Lee, Dongeun Yong, Kyungwon Lee
BACKGROUND: Diverse microbiota exist in the lower respiratory tract. Although next generation sequencing (NGS) is the most widely used microbiome analysis technique, it is difficult to implement NGS in clinical microbiology laboratories. Therefore, we evaluated the performance of conventional culture methods together with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in identifying microbiota in bronchoalveolar lavage (BAL) fluid. METHODS: BAL fluid samples (n=27) were obtained from patients undergoing diagnostic bronchoscopy for lung mass evaluation...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29214445/auxin-enhances-grafting-success-in-carya-cathayensis-chinese-hickory
#18
R M Saravana Kumar, Liu Xiao Gao, Hu Wei Yuan, Dong Bin Xu, Zhao Liang, Shen Chen Tao, Wen Bin Guo, Dao Liang Yan, Bing Song Zheng, Johan Edqvist
Application of auxin to root stock and scion increases the success rate of grafting in Chinese hickory. The nuts of the Chinese hickory (Carya cathayensis) tree are considered both delicious and healthy. The popularity and high demand result is that the hickory nuts are of very high economical value for horticulture. This is particularly true for the Zhejiang province in eastern China where this tree is widely cultivated. However, there are several difficulties surrounding the hickory cultivation, such as for example long vegetative growth, tall trees, labour-intensive nut picking, and slow variety improvements...
December 6, 2017: Planta
https://www.readbyqxmd.com/read/29213187/the-role-of-the-whitefly-bemisia-tabaci-gennadius-and-farmer-practices-in-the-spread-of-cassava-brown-streak-ipomoviruses
#19
Midatharahally N Maruthi, Simon C Jeremiah, Ibrahim U Mohammed, James P Legg
Cassava brown streak disease (CBSD) is arguably the most dangerous current threat to cassava, which is Africa's most important food security crop. CBSD is caused by two RNA viruses: Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV). The roles of the whitefly Bemisia tabaci (Gennadius) and farmer practices in the spread of CBSD were investigated in a set of field and laboratory experiments. The virus was acquired and transmitted by B. tabaci within a short time (5-10 min each for virus acquisition and inoculation), and was retained for up to 48 hr...
December 2017: Journal of Phytopathology (1986)
https://www.readbyqxmd.com/read/29212933/characterization-of-an-influenza-virus-pseudotyped-with-ebolavirus-glycoprotein
#20
Julie Xiao, Pramila Rijal, Lisa Schimanski, Arun Kumar Tharkeshwar, Edward Wright, Wim Annaert, Alain Townsend
We have produced a new Ebola virus pseudotype: E-S-FLU, which can be handled in biosafety level-1/2 containment for laboratory analysis. E-S-FLU is a single cycle influenza virus coated with Ebolavirus glycoprotein, and it encodes enhanced green fluorescence protein as a reporter that replaces the influenza haemagglutinin. MDCK-SIAT1 cells were transduced to express Ebolavirus glycoprotein as a stable transmembrane protein for E-S-FLU production. Infection of cells by E-S-FLU was dependent on Niemann-Pick C1 protein, which is the well-characterized receptor for Ebola virus entry at the late endosome/lysosome membrane...
December 6, 2017: Journal of Virology
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