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Retinol homocysteine

Nina Rica Wium Geiker, Mette Veller, Louise Kjoelbaek, Jette Jakobsen, Christian Ritz, Anne Raben, Arne Astrup, Janne Kunchel Lorenzen, Lesli H Larsen, Susanne Bügel
Background: Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12 , D and E status and the degree of inflammation. Methods: Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2 , completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12 , D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED...
2018: Nutrition & Metabolism
Øivind Midttun, Adrian McCann, Ove Aarseth, Marit Krokeide, Gry Kvalheim, Klaus Meyer, Per Magne Ueland
Targeted metabolic profiling characterized by complementary platforms, multiplexing and low volume consumption are increasingly used for studies using biobank material. Using liquid-liquid extraction, we developed a sample workup suitable for quantification of 6 fat- and 26 water-soluble biomarkers. 50μL of serum/plasma was mixed with dithioerythritol, ethanol and isooctane/chloroform. The organic layer was used for analysis of the fat-soluble vitamins all-trans retinol (A), 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, α-tocopherol (E), γ-tocopherol (E) and phylloquinone (K1) by LC-MS/MS...
October 7, 2016: Analytical Chemistry
Manjeswori Ulak, Ram K Chandyo, Andrew L Thorne-Lyman, Sigrun Henjum, Per M Ueland, Øivind Midttun, Prakash S Shrestha, Wafaie W Fawzi, Lauren Graybill, Tor A Strand
Vitamin deficiencies are known to be common among infants residing in low- and middle-income countries but relatively few studies have assessed several biochemical parameters simultaneously. The objective of the study was to describe the status of vitamins (A, D, E, B₆, B12 and folate) in breastfed infants. We measured the plasma concentrations of trans retinol, 25 hydroxy vitamin D, α-tocopherol, pyridoxal 5'-phosphate, cobalamin, folate, methylmalonic acid, homocysteine, hemoglobin and C-reactive protein from 467 randomly selected infants...
March 8, 2016: Nutrients
María Navarro-Solera, Joaquín Carrasco-Luna, Gonzalo Pin-Arboledas, Rebeca González-Carrascosa, José M Soriano, Pilar Codoñer-Franch
OBJECTIVE: The aim of the present study was to evaluate the influence of sleep duration on cardiovascular risk factors in obese children. METHODS: Cross-sectional analysis of 90 obese children ages 7 to 16 years. Anthropometric and clinical evaluation with specification of dietary and lifestyle habits was carried out during an office visit. Sleep duration was evaluated by the BEARS (B = bedtime issues, E = excessive daytime sleepiness, A = night awakening, R = regularity and duration of sleep, S = snoring) questionnaire on children's sleep characteristics...
November 2015: Journal of Pediatric Gastroenterology and Nutrition
Felipe R Bruniera, Felipe M Ferreira, Luiz R M Savioli, Marcelo R Bacci, David Feder, Edimar C Pereira, Mavilde L G Pedreira, Maria A S Peterlini, Fábio F Perazzo, Ligia A Azzalis, Paulo C P Rosa, Virginia B C Junqueira, Monica A Sato, Fernando L A Fonseca
Vancomycin (VCM) is indicated in combat against Gram-positive infections, but it is not considered a first-choice drug because of its adverse effects. It is believed that oxidative stress is the primary mechanism of endothelial injury and the consequent VCM toxicity, which varies from phlebitis to nephrotoxicity. Moreover, dose recommendations, dilution, rates and types of infusion are still controversial. The aim of this study was to determine the effect of different VCM dilutions in endothelial, liver and kidney injuries by biochemical parameters and histopathological analysis...
December 2014: Anais da Academia Brasileira de Ciências
Yves Ingenbleek, Larry H Bernstein
Lean body mass (LBM) encompasses all metabolically active organs distributed into visceral and structural tissue compartments and collecting the bulk of N and K stores of the human body. Transthyretin (TTR) is a plasma protein mainly secreted by the liver within a trimolecular TTR-RBP-retinol complex revealing from birth to old age strikingly similar evolutionary patterns with LBM in health and disease. TTR is also synthesized by the choroid plexus along distinct regulatory pathways. Chronic dietary methionine (Met) deprivation or cytokine-induced inflammatory disorders generates LBM downsizing following differentiated physiopathological processes...
2015: Journal of Alzheimer's Disease: JAD
Valentina Bollati, Chiara Favero, Benedetta Albetti, Letizia Tarantini, Alice Moroni, Hyang-Min Byun, Valeria Motta, Diana Misaela Conti, Amedea Silvia Tirelli, Luisella Vigna, Pier Alberto Bertazzi, Angela Cecilia Pesatori
The aim of the present study was to evaluate the potential association between dietary nutrients and alterations in DNA methylation in a set of five candidate genes, including CD14, Et-1, iNOS, HERV-w and TNFα, in a population of overweight/obese subjects. We evaluated possible associations between gene methylation and clinical blood parameters, including total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C and HDL-C), triglyceride and homocysteine levels. We employed validated methods to assess anthropometric, clinical and dietary data, as well as pyrosequencing to evaluate DNA methylation of the five candidate genes in 165 overweight/obese subjects...
October 2014: Nutrients
May A Beydoun, Alyssa A Gamaldo, Jose A Canas, Hind A Beydoun, Mauli T Shah, Jessica M McNeely, Alan B Zonderman
BACKGROUND: The associations between nutritional biomarkers and measures of sleep quantity and quality remain unclear. METHODS: Cross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2005-2006 were used. We selected 2,459 adults aged 20-85, with complete data on key variables. Five sleep measures were constructed as primary outcomes: (A) Sleep duration; (B) Sleep disorder; (C) Three factors obtained from factor analysis of 15 items and labeled as "Poor sleep-related daytime dysfunction" (Factor 1), "Sleepiness" (Factor 2) and "Sleep disturbance" (Factor 3)...
2014: PloS One
Melissa J Morine, Jacqueline Pontes Monteiro, Carolyn Wise, Candee Teitel, Lisa Pence, Anna Williams, Baitang Ning, Beverly McCabe-Sellers, Catherine Champagne, Jerome Turner, Beatrice Shelby, Margaret Bogle, Richard D Beger, Corrado Priami, Jim Kaput
The discovery of vitamins and clarification of their role in preventing frank essential nutrient deficiencies occurred in the early 1900s. Much vitamin research has understandably focused on public health and the effects of single nutrients to alleviate acute conditions. The physiological processes for maintaining health, however, are complex systems that depend upon interactions between multiple nutrients, environmental factors, and genetic makeup. To analyze the relationship between these factors and nutritional health, data were obtained from an observational, community-based participatory research program of children and teens (age 6-14) enrolled in a summer day camp in the Delta region of Arkansas...
July 2014: Genes & Nutrition
Oivind Midttun, Mary K Townsend, Ottar Nygård, Shelley S Tworoger, Paul Brennan, Mattias Johansson, Per Magne Ueland
Knowledge of stability during sample transportation and changes in biomarker concentrations within person over time are paramount for proper design and interpretation of epidemiologic studies based on a single measurement of biomarker status. Therefore, we investigated stability and intraindividual vs. interindividual variation in blood concentrations of biomarkers related to vitamin status, one-carbon metabolism, and the kynurenine pathway. Whole blood (EDTA and heparin, n = 12) was stored with an icepack for 24 or 48 h, and plasma concentrations of 38 biomarkers were determined...
May 2014: Journal of Nutrition
Scott F Dowell, James J Sejvar, Lul Riek, Katelijn A H Vandemaele, Margaret Lamunu, Annette C Kuesel, Erich Schmutzhard, William Matuja, Sudhir Bunga, Jennifer Foltz, Thomas B Nutman, Andrea S Winkler, Anthony K Mbonye
An epidemic illness characterized by head nodding associated with onchocerciasis has been described in eastern Africa since the early 1960s; we summarize published reports and recent studies. Onset of nodding occurs in previously healthy 5-15-year-old children and is often triggered by eating or cold temperatures and accompanied by cognitive impairment. Its incidence has increased in Uganda and South Sudan over the past 10 years. Four case-control studies identified modest and inconsistent associations. There were nonspecific lesions seen by magnetic resonance imaging, no cerebrospinal fluid inflammation, and markedly abnormal electroencephalography results...
2013: Emerging Infectious Diseases
Laura E Tomedi, Chung-Chou H Chang, P K Newby, Rhobert W Evans, James F Luther, Katherine L Wisner, Lisa M Bodnar
OBJECTIVE: Pre-pregnancy obesity has been associated with adverse birth outcomes. Poor essential fatty acid (EFA) and micronutrient status during pregnancy may contribute to these associations. We assessed the associations between pre-pregnancy BMI and nutritional patterns of maternal micronutrient and EFA status during mid-pregnancy. DESIGN: A cross-sectional analysis from a prospective cohort study. Women provided non-fasting blood samples at ≥ 20 weeks’ gestation that were assayed for red cell EFA; plasma folate, homocysteine and ascorbic acid; and serum retinol, 25-hydroxyvitamin D, a-tocopherol, soluble transferrin receptors and carotenoids...
August 2013: Public Health Nutrition
Max Leenders, Martine M Ros, Ivonne Sluijs, Hendriek C Boshuizen, Carla H van Gils, Eugène H J M Jansen, H Bas Bueno-de-Mesquita
Many epidemiological studies assess nutritional status based on single blood measurements, without verifying if these remain reliable over repeated measurements. This study assessed the reliability over a period of 2 to 5 yr of plasma carotenoids, vitamin C, retinol, tocopherols, and serum compounds involved in 1-carbon metabolism in a subsample of Dutch participants of European Prospective Investigation into Cancer and Nutrition (EPIC). Blood samples from 38 men from MORGEN-EPIC and 35 women from Prospect-EPIC were collected between 1993 and 1997 and again after 2 to 5 yr...
2013: Nutrition and Cancer
Iveta Garaiova, Jana Muchová, Zuzana Nagyová, Csilla Mišľanová, Stanislav Oravec, Andrej Dukát, Duolao Wang, Sue F Plummer, Zdeňka Ďuračková
BACKGROUND: Assessment of cardiovascular disease (CVD) risk factors can predict clinical manifestations of atherosclerosis in adulthood. In this pilot study with hypercholesterolemic children and adolescents, we investigated the effects of a combination of plant sterols, fish oil and B vitamins on the levels of four independent risk factors for CVD; LDL-cholesterol, triacylglycerols, C-reactive protein and homocysteine. METHODS: Twenty five participants (mean age 16 y, BMI 23 kg/m2) received daily for a period of 16 weeks an emulsified preparation comprising plant sterols esters (1300 mg), fish oil (providing 1000 mg eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA)) and vitamins B12 (50 μg), B6 (2...
2013: Nutrition Journal
Jorge Romaní, Assumpta Caixàs, Victoria Ceperuelo-Mallafré, José Manuel Carrascosa, Miquel Ribera, Mercedes Rigla, Joan Vendrell, Jesús Luelmo
Psoriasis has been related to metabolic syndrome (MS). Adipocytokines produced by white adipose tissue may be involved in the pathogenesis of psoriasis and its association with MS. Our objectives were to characterize the profile of a number of different inflammatory and atherogenic markers, vitamins, adipokines and cytokines and their potential involvement in MS in patients with moderate-to-severe psoriasis without joint involvement compared to anthropometrically matched controls, and to evaluate correlation with severity of the skin disease and changes after narrow-band UVB (NB-UVB) phototherapy...
March 2013: Archives of Dermatological Research
Kwok Leung Ong, Kerry-Anne Rye, Rachel O'Connell, Alicia J Jenkins, Chris Brown, Aimin Xu, David R Sullivan, Philip J Barter, Anthony C Keech
CONTEXT: Fenofibrate is a peroxisome proliferator-activated receptor (PPAR)-α agonist that showed beneficial effects on total cardiovascular risk in patients with type 2 diabetes in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. OBJECTIVE: This study aimed to investigate the long-term effect of fenofibrate therapy on three novel biomarkers of cardiovascular risk, namely adipocyte-fatty acid-binding protein (A-FABP), fibroblast growth factor 21 (FGF21), and retinol-binding protein 4 (RBP4), which are all downstream targets of PPAR-α or PPAR-γ, in patients with type 2 diabetes...
December 2012: Journal of Clinical Endocrinology and Metabolism
Andrew J Clifford, Kehui Chen, Laura McWade, Gonzalo Rincon, Seung-Hyun Kim, Dirk M Holstege, Janel E Owens, Bitao Liu, Hans-Georg Müller, Juan F Medrano, James G Fadel, Alanna J Moshfegh, David J Baer, Janet A Novotny
Using linear regression models, we studied the main and 2-way interaction effects of the predictor variables gender, age, BMI, and 64 folate/vitamin B-12/homocysteine (Hcy)/lipid/cholesterol-related single nucleotide polymorphisms (SNP) on log-transformed plasma Hcy normalized by RBC folate measurements (nHcy) in 373 healthy Caucasian adults (50% women). Variable selection was conducted by stepwise Akaike information criterion or least angle regression and both methods led to the same final model. Significant predictors (where P values were adjusted for false discovery rate) included type of blood sample [whole blood (WB) vs...
September 2012: Journal of Nutrition
Kilmer S McCully
Hyperhomocysteinemia was first associated with degenerative disease by observation of accelerated arteriosclerosis in children with inherited disorders of cystathionine synthase, methionine synthase, and methylene tetrohydrofolate reductase. The metabolic blockade of sulfate synthesis from homocysteine thiolactone in malignant cells is ascribed to a deficiency of a chemopreventive derivative of homocysteine thiolactone that occurs in normal cells. Its chemical structure was elucidated by the organic synthesis of thioretinamide from retinoic acid and homocysteine thiolactone...
2011: Annals of Clinical and Laboratory Science
Lisa M Bodnar, Katherine L Wisner, James F Luther, Robert W Powers, Rhobert W Evans, Marcia J Gallaher, P K Newby
OBJECTIVE: Major depressive disorder (MDD) during pregnancy increases the risk of adverse maternal and infant outcomes. Maternal nutritional status may be a modifiable risk factor for antenatal depression. We evaluated the association between patterns in mid-pregnancy nutritional biomarkers and MDD. DESIGN: Prospective cohort study. SETTING: Pittsburgh, Pennsylvania, USA. SUBJECTS: Women who enrolled at ≤20 weeks' gestation and had a diagnosis of MDD made with the Structured Clinical Interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th edition) at 20-, 30- and 36-week study visits...
June 2012: Public Health Nutrition
L Brazionis, K Z Walker, C Itsiopoulos, K O'Dea
BACKGROUND AND AIMS: Vitamin A affects inflammation and immune function and is thus a factor of interest in relation to cardiovascular disease (CVD). As vitamin A circulates in the plasma in the form of retinol, this study aims to describe the relationship between plasma retinol and the 5-year incidence of CVD mortality. METHODS AND RESULTS: Community-dwelling adults (n = 441, 45% with type 2 diabetes) were recruited in Melbourne, assessed at baseline and followed for 5 years...
October 2012: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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