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tilt optical disc

Youngkyo Kwun, Gyule Han, Yoon-Jung Choy, Jong Chul Han, Changwon Kee
PURPOSE OF THE STUDY: The purpose of the study was to evaluate the optic disc characteristics associated with visual field (VF) progression in normal tension glaucoma (NTG) eyes with tilted optic discs. METHODS: Sixty-six eyes of 66 NTG patients with tilted optic disc were included in this cross-sectional study, who were examined by at least 5 Humphrey 30-2 VFs. Glaucomatous VF progression was evaluated using pointwise linear regression. Optic nerve heads were scanned with enhanced-depth imaging optical coherence tomography (EDI-OCT), and evaluated for the focal lamina cribrosa (LC) defects and LC thicknesses...
October 14, 2016: Journal of Glaucoma
Takehiro Yamashita, Taiji Sakamoto, Naoya Yoshihara, Hiroto Terasaki, Minoru Tanaka, Yuya Kii, Kumiko Nakao
PURPOSE: To determine the correlations between the retinal nerve fiber layer thickness (RNFLT) and the axial length, peripapillary retinal tilt (PRT), and optic disc size, and retinal artery position. METHODS: A prospective, observational cross-sectional study of 119 healthy right eyes of 119 volunteers. All participants underwent comprehensive ophthalmologic examinations including peripapillary RNFLT imaging and measurements of the axial length. The RNFLT was determined by the TOPCON 3D OCT-1000, MARK II...
October 6, 2016: Journal of Glaucoma
Jong Rak Lee, Jiyun Lee, Jong-Eun Lee, Jin Young Lee, Michael S Kook
PURPOSE: To compare global and regional visual field (VF) progression rates and determine clinical factors associated with rapid VF progression in myopic patients with open-angle glaucoma (OAG) with different disc tilt directions. METHODS: The medical records of 182 eyes from 182 myopic OAG patients with progressive VF deterioration during follow-up were analyzed. The rates of change in the mean thresholds of the global and regional VF areas of the horizontal and vertical disc tilt (HDT and VDT) groups were compared using a linear mixed model after controlling for confounding covariates...
October 6, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Edita Dervisevic, Suzana Pavljasevic, Almir Dervisevic, Sanja Sefic Kasumovic
INTRODUCTION: Glaucoma is the most common optic neuropathy which is characterized by progressive loss of retinal ganglion cells, the excavation of the optic nerve head, associated with defects in the visual field. It is not a disease, but the final result of united and yet completely unidentified cellular and subcellular processes and effects of many factors responsible for changes in retinal ganglion cells leading to their accelerated apoptosis. METHODS: This is a prospective-retrospective, comparative, randomized clinical trial that included 150 patients, 97 were female and 53 male...
June 2016: Medical Archives
Yu Sawada, Masanori Hangai, Makoto Ishikawa, Takeshi Yoshitomi
PURPOSE: To examine the association of myopia with the visual field (VF) defects in open-angle glaucoma (OAG) using paired eyes to eliminate the effect of unknown confounding factors that are diverse among individuals. METHODS: One hundred eighteen eyes of 59 subjects with myopia (spherical equivalent [SE] ≥ -2 diopter [D] and axial length ≥ 24.0 mm) whose intra-ocular pressure between paired eyes was similar and the mean deviation (MD) of the Humphrey VF test differed by more than 6 dB were included...
2016: PloS One
Takehiro Yamashita, Taiji Sakamoto, Naoya Yoshihara, Hiroto Terasaki, Minoru Tanaka, Yuya Kii, Kumiko Nakao
PURPOSE: Eyes with a peripapillary nerve fiber elevation (pNFE) are those with a discrepancy between the optic disc margin in a color fundus photograph and the Bruch's membrane opening in an optical coherent tomographic (OCT) cross-sectional image. The purpose of this study was to determine the prevalence of pNFE in young healthy eyes, and to compare the axial length and optic disc tilt between pNFE and non-pNFE groups. METHODS: This was a prospective, observational, cross-sectional study of 117 right eyes...
August 1, 2016: Investigative Ophthalmology & Visual Science
Jong Eun Lee, Jiyun Lee, Jin Young Lee, Michael S Kook
PURPOSE OF THE STUDY: The purpose of the study was to compare patterns of damage in young myopic glaucomatous-appearing patients with horizontal disc tilt (HDT) to a control group of patients with vertical disc tilt (VDT). PATIENTS AND METHODS: We consecutively enrolled 104 eyes of 104 young, myopic, glaucomatous-appearing patients without or with early visual field (VF) defects. The eyes were divided into those with HDT or VDT. The clinical characteristics of the peripapillary retinal nerve fiber layer (pRNFL) and VF damage were compared between groups after matching for age, refractive error, and neural rim area using spectral-domain optical coherence tomography and standard automated perimetry 24-2 VF testing...
August 22, 2016: Journal of Glaucoma
Nasrin Moghadas Sharif, Nasser Shoeibi, Asieh Ehsaei, Edward A H Mallen
PURPOSE: The purpose of this study was to compare retinal thickness and biometric parameters between highly myopic eyes with and without tilted optic discs. METHODS: A total of 60 eyes from 60 highly myopic individuals (defined as a mean spherical equivalent refraction of -6.00 D or greater and axial length ≥26 mm) underwent detailed ophthalmic examination. Twenty-one eyes (13 females and 8 males; mean age: 29 ± 7 years) with tilted optic discs were recruited and compared with 39 eyes (23 females and 16 males; mean age: 28 ± 6 years) of control subjects without tilted optic discs using spectral domain optical coherence tomography (OCT) and the Lenstar biometer...
August 22, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Eun Ji Lee, Kyoung Min Lee, Hyunjoong Kim, Tae-Woo Kim
PURPOSE: To compare the diagnostic ability of the new spectral-domain optical coherence tomography (SD-OCT) algorithm for measuring circumpapillary retinal nerve fiber layer (RNFL) thickness centered on Bruch's membrane opening (BMO), with the conventional circumpapillary RNFL thickness measurement centered on the optic disc. METHODS: In 75 eyes with primary open-angle glaucoma (POAG) and 71 healthy control eyes, circumpapillary RNFL thickness was measured with SD-OCT, first by centering the scan circle on the optic disc (RNFLDi), and then on the BMO (RNFLBMO)...
August 1, 2016: Investigative Ophthalmology & Visual Science
Yung Ju Yoo, Eun Ji Lee, Tae-Woo Kim
PURPOSE: To investigate intereye differences in the parapapillary atrophy (PPA) microstructure in unilateral primary open-angle glaucoma (POAG). METHODS: Bilateral optic nerves from 172 unilateral POAG patients having clinical PPA shown in infrared fundus imaging were scanned using spectral-domain optical coherence tomography (SD-OCT). Based on the extent of Bruch's membrane (BM) within the PPA area, the PPA was divided into β-zone (area with BM) and γ-zone (area devoid of BM)...
August 1, 2016: Investigative Ophthalmology & Visual Science
Tomoko Miyake, Shota Kojima, Tetsuya Sugiyama, Mari Ueki, Jun Sugasawa, Hidehiro Oku, Kensuke Tajiri, Yuka Shigemura, Koichi Ueda, Atsuko Harada, Mami Yamasaki, Takumi Yamanaka, Hidetsuna Utsunomiya, Tsunehiko Ikeda
INTRODUCTION: The incidence of facial cleft is rare and ranges between 1.43 and 4.85 per 100,000 births. To date, there have been few reports of detailed ophthalmologic examinations performed in cases of facial cleft. Here, we report a case of optic-nerve hypoplasia and anterior segment abnormality associated with facial cleft. CASE REPORT: A 9-day-old female infant was delivered by cesarian section at 34 weeks of gestational age (the second baby of twins) and weighed 2,276 g upon presentation...
2016: International Medical Case Reports Journal
Jong Chul Han, Eun Jung Lee, Seung Hoon Kim, Changwon Kee
PURPOSE: To understand the long-term characteristics of visual field (VF) progression in myopic open-angle glaucoma (OAG) according to the morphology of optic disc tilt. DESIGN: Retrospective, comparative, longitudinal cohort study. METHODS: Myopic OAG eyes were divided into temporally tilted disc and inferiorly tilted disc groups according to optic disc torsional degrees. Kaplan-Meier survival analysis was used to compare the survival rates between nonmyopic OAG, myopic OAG with temporally tilted disc, and myopic OAG with inferiorly tilted disc...
September 2016: American Journal of Ophthalmology
Yuri Fujino, Takehiro Yamashita, Hiroshi Murata, Ryo Asaoka
PURPOSE: To investigate whether correcting the circumpapillary retinal nerve fiber layer (cpRNFL) thickness profile, using retinal artery position and papillomacular bundle tilt, can improve the structure-function relationship in glaucoma patients. METHODS: Spectral-domain optical coherence tomography (SD-OCT) and visual field measurements were conducted in 142 eyes of 90 subjects with open angle glaucoma. The SD-OCT cpRNFL thickness profile was corrected for retinal artery position and/or papillomacular tilt in all twelve 30° sectors of the optic disc, and the structure-function relationship against corresponding 30° sectorial retinal sensitivity was investigated by using linear mixed model...
June 1, 2016: Investigative Ophthalmology & Visual Science
Hiroto Terasaki, Takehiro Yamashita, Naoya Yoshihara, Yuya Kii, Minoru Tanaka, Kumiko Nakao, Taiji Sakamoto
Tessellated fundus is found as common and early-phase characteristic of myopic eyes and their locations are varied among patients. However, the relationship between their locations and morphological parameters of the eyes is still unknown. The purpose is this study is to determine the locations of the tessellations in the ocular fundus of young healthy eyes, and to determine relationships between their locations and morphological parameters of the eyes. This is a prospective observational cross sectional study of 126 eyes of 126 healthy volunteers (mean age 26...
2016: PloS One
Mi Sun Sung, Yeon Soo Kang, Hwan Heo, Sang Woo Park
PURPOSE: To investigate factors associated with visual field (VF) progression in myopic normal-tension glaucoma (NTG) and to determine the relationship between optic disc rotation and VF progression. DESIGN: Retrospective, observational study. SUBJECTS: Ninety-two patients with myopic NTG, with VF loss confined to a single hemifield, who were followed up over a 2-year period. METHODS: Systemic and ocular findings such as optic disc tilt and optic disc rotation were evaluated...
July 2016: Ophthalmology
Li-Wei Chen, Yu-Wen Lan, Jui-Wen Hsieh
PURPOSE: To evaluate the morphologic characteristics of optic neuropathy and its association with visual field (VF) defects in primary open-angle glaucoma (POAG) eyes with high myopia. METHODS: In this cross-sectional study, we reviewed data from 375 Taiwanese patients (375 eyes) of POAG, ages 20 to 60 years. Optic disc photographs were used for planimetric measurements of morphologic variables. The myopic refraction was divided into high myopia (<-6.0 D) and nonhigh myopia (moderate myopia to hyperopia)...
June 2016: Journal of Glaucoma
Younhea Jung, Hae-Young L Park, Chan Kee Park
PURPOSE: To investigate the relationships between corneal deformation amplitude and posterior pole profiles, including β-zone parapapillary atrophy (βPPA), optic disc tilt ratio, torsion degree, and disc-foveal angle, in patients with glaucoma. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 107 patients with glaucoma. METHODS: Each patient underwent measurement of deformation amplitude with Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany), color optic disc photography, red-free retinal nerve fiber layer photography, axial length measurement, and 24-2 standard automated perimetry...
May 2016: Ophthalmology
Giovanni Taibbi, Ronita L Cromwell, Susana B Zanello, Patrice O Yarbough, Robert J Ploutz-Snyder, Bernard F Godley, Gianmarco Vizzeri
PURPOSE: To compare ocular outcomes in healthy subjects undergoing 14- and/or 70-day head-down-tilt (HDT) bed rest (BR). METHODS: Participants were selected by using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects maintained a 6° HDT position for 14 and/or 70 consecutive days. Weekly ophthalmologic examinations were performed in the sitting (pre/post-BR only) and HDT positions. Mixed-effects linear models compared pre- and post-HDT BR observations between 14- and 70-day HDT BR in best-corrected visual acuity, spherical equivalent, intraocular pressure (IOP), Spectralis OCT retinal nerve fiber layer thickness, peripapillary and macular retinal thicknesses...
February 2016: Investigative Ophthalmology & Visual Science
Jong Chul Han, Seok Ho Cho, Dae Yong Sohn, Changwon Kee
PURPOSE: We investigated the lamina cribrosa (LC) structural characteristics of myopic eyes with and without open-angle glaucoma (OAG) using enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT). METHODS: Defects in the LC in myopic eyes with and without OAG and normal eyes without myopia were evaluated using EDI SD-OCT. Among the two types of LC defects, disinsertion type and hole type, the associations among disinsertion type LC defects, myopia-related parameters of axial length (AL), maximal γ-zone peripapillary atrophy (PPA) length, disc tilt angle, and the presence of glaucoma were evaluated...
February 2016: Investigative Ophthalmology & Visual Science
Victor Koh, Colin Tan, Pei Ting Tan, Marcus Tan, Vinay Balla, Gerard Nah, Ching-Yu Cheng, Kyoko Ohno-Matsui, Mellisa M H Tan, Adeline Yang, Paul Zhao, Tien Yin Wong, Seang-Mei Saw
PURPOSE: To determine the prevalence and risk factors of myopic maculopathy and specific optic disc and macular changes in highly myopic eyes of young Asian adults and their impact on visual acuity. DESIGN: Prospective cross-sectional study. METHODS: In total, 593 highly myopic (spherical equivalent refraction [SER] less than -6.00 diopters [D]) and 156 emmetropic (SER between -1.00 and +1.00 D) male participants from a population-based survey were included...
April 2016: American Journal of Ophthalmology
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