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tilt optical disc

Maria Veronica Strehaianu, Dana Dascalescu, Catalina Ionescu, Miruna Burcel, Vasile Potop, Catalina Corbu
Glaucoma is an optic neuropathy that affects the ganglion cell complex in all its components: cell bodies, dendrites, and axons, the dendritic arbor being the first one damaged. This is the reason why the thickness of the ganglion cell and internal plexiform layers can be taken into account as an early predictor of the glaucomatous changes, along with the retinal nerve fiber layer (RNFL) thickness. However, due to disc tilting and peripapillary atrophy, the RNFL evaluation may be prone to errors in myopic patients...
October 2017: Romanian Journal of Ophthalmology
Mi Sun Sung, Tae Hee Lee, Hwan Heo, Sang Woo Park
PURPOSE: To evaluate the retinal microvasculature of peripapillary and macular regions in highly myopic eyes and investigate the association between the vascular parameters and optic nerve head (ONH) deformation. DESIGN: Cross-sectional study METHODS: Seventy-one subjects with highly myopic eyes and 26 subjects with emmetropic eyes were included. Horizontal B-scan images of the ONH were obtained using optical coherence tomography (OCT) and horizontal tilt angles were measured...
February 5, 2018: American Journal of Ophthalmology
Jaclyn Chiang, Michael Yapp, Angelica Ly, Michael P Hennessy, Michael Kalloniatis, Barbara Zangerl
SIGNIFICANCE: This study resulted in the identification of an optic nerve head (ONH) feature associated with tilted optic discs, which might potentially contribute to ONH pathologies. Knowledge of such findings will enhance clinical insights and drive future opportunities to understand disease processes related to tilted optic discs. PURPOSE: The aim of this study was to identify novel retinal nerve fiber layer (RNFL) anomalies by evaluating tilted optic discs using optical coherence tomography...
February 3, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Yee-Ling Wong, Yang Ding, Charumathi Sabanayagam, Chee-Wai Wong, Pavan Verkicharla, Kyoko Ohno-Matsui, Donald Tan, Anna Chwee-Hong Yeo, Quan V Hoang, Ecosse Lamoureux, Seang-Mei Saw
OBJECTIVES: To examine the progression pattern of disc and retinal lesions in highly myopic Chinese adolescents over a 10-year period in Singapore. METHODS: This longitudinal study included Chinese participants who showed high myopia (spherical equivalent [SE] worse than or equal to -5 diopters [D]), no history of refractive surgery, and available fundus photographs at both 2006 (baseline) and 2016 (10-year follow-up) visits. Forty-four adolescents (aged 12-16 years at baseline) who were re-examined later at follow-up were included...
January 22, 2018: Eye & Contact Lens
Yong Chan Kim, Ji-Sun Moon, Hae-Young Lopilly Park, Chan Kee Park
For over a century, tilted disc syndrome (TDS) has been defined vaguely. The lack of consensus of the terminology arises from the lack of understanding of the pathogenesis of this condition. Also, myopic discs with temporal crescents or peripapillary atrophy (PPA) are histologically indistinguishable from TDS. Therefore, we examined the morphological background of the extreme ONH appearances such as the myopic tilted disc and the TDS by analyzing the posterior segment of the eye from a three-dimensional (3D) perspective...
January 18, 2018: Scientific Reports
Kunliang Qiu, Geng Wang, Xuehui Lu, Riping Zhang, Lixia Sun, Mingzhi Zhang
PURPOSE: We determined the applicability of inferior > superior > nasal > temporal (ISNT) rules on retinal nerve fibre layer (RNFL) thickness and rim area and evaluated the impact of various ocular factors on the performance of the ISNT rules in healthy myopic eyes. METHODS: A total of 138 eyes from 138 healthy myopic subjects were included in this cross-sectional observational study. The peripapillary RNFL and optic disc in each eye were imaged with Cirrus HD optical coherence tomography (OCT) and Heidelberg Retina Tomograph II (HRT2), respectively...
March 2018: Acta Ophthalmologica
Roberto Saenz, Han Cheng, Thomas C Prager, Laura J Frishman, Rosa A Tang
SIGNIFICANCE: Differentiating papilledema from pseudopapilledema reflecting tilted/crowded optic discs or disc drusen is critical but can be challenging. Our study suggests that spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness and retrobulbar optic nerve sheath diameter (ONSD) measured by A-scan ultrasound provide useful information when differentiating the two conditions. PURPOSE: To evaluate the use of A-scan ultrasound and spectral-domain OCT retinal nerve fiber layer thickness (RNFLT) in differentiating papilledema associated with idiopathic intracranial hypertension from pseudopapilledema...
December 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Jiyun Lee, Jong Eun Lee, Junki Kwon, Joong Won Shin, Michael S Kook
PURPOSE: To assess the topographic correlation between optic disc torsion (ODT) and beta-zone peripapillary atrophy (β-PPA) in young patients with myopia and glaucomatous-appearing visual field defects (VFDs). PATIENTS AND METHODS: We consecutively recruited 110 eyes of 110 young patients with myopia and glaucomatous-appearing VFDs. Retinal nerve fiber layer (RNFL) and macular ganglion cell inner plexiform layer (mGCIPL) thicknesses were measured to compare between the groups with different ODT directions...
November 7, 2017: Journal of Glaucoma
Takehiro Yamashita, Taiji Sakamoto, Naoya Yoshihara, Hiroto Terasaki, Minoru Tanaka, Yuya Kii, Kumiko Nakao
Optical coherence tomography (OCT) has made it possible for clinicians to measure the peripapillary choroidal thickness (ppCT) noninvasively in various ocular diseases. However, the ocular factors associated with the ppCT have not been conclusively determined. The purpose of this study was to determine the relationship between the local ppCT and the axial length, optic disc tilt, and the angle of the papillo-macular position (PMP) in healthy eyes. This was a prospective, observational cross-sectional study of 119 right eyes of 119 healthy Japanese volunteers...
2017: PloS One
Maria Fernanda Abalem, Pedro Carlos Carricondo, Helen Nazareth Veloso Dos Santos, Rafael Garcia, Cynthia X Qian, John Helal, Eduardo Cunha de Souza, Walter Yukihiko Takahashi
A 70-year-old woman presented with 20/200 visual acuity in the right eye. Multimodal imaging revealed tilted disc syndrome (TDS) with macular serous detachment (MSD) and pigmentary changes at the temporal margin of the optic disc. Subretinal fluid persisted after three monthly intravitreal bevacizumab (Avastin; Genentech, South San Francisco, CA) injections and threshold focal laser photocoagulation. Subsequently, confluent subthreshold argon laser was applied over the entire area of retinal pigment epithelium (RPE) abnormalities, resulting in the resolution of subretinal fluid without recurrence through 3 years of follow-up...
September 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
Simrenjeet Sandhu, Chris Rudnisky, Sourabh Arora, Faazil Kassam, Gordon Douglas, Marianne C Edwards, Karin Verstraten, Beatrice Wong, Karim F Damji
SYNOPSIS: Clinicians can feel confident compressed three-dimensional digital (3DD) and two-dimensional digital (2DD) imaging evaluating important features of glaucomatous disc damage is comparable to the previous gold standard of stereoscopic slide film photography, supporting the use of digital imaging for teleglaucoma applications. BACKGROUND/AIMS: To compare the sensitivity and specificity of 3DD and 2DD photography with stereo slide film in detecting glaucomatous optic nerve head features...
August 23, 2017: British Journal of Ophthalmology
Seungbong Han, Kyung Rim Sung, Jimin Park, Joo Young Yoon, Joong Won Shin
PURPOSE: To investigate the sub-classification of myopic glaucomatous eyes by optic disc and peripapillary features. METHODS: Optic disc tilt and torsion were determined from retinal nerve fiber layer photographs. Based on the location of the Bruch's membrane (BM) opening within the β-zone of the peripapillary atrophy (PPA) area, the widths of β-zone PPA (PPA1W), PPA+BM (PPA2W), and PPA-BM (PPA3W) were measured with enhanced depth imaging spectral-domain optical coherence tomography...
2017: PloS One
M Haruta, R Kodama, R Yamakawa
PurposeTo determine the clinical usefulness of optical coherence tomography (OCT) for detecting thinning of the retinal nerve fiber layer (RNFL) in eyes with nasal hypoplasia of the optic discs (NHOD).Patients and methodsThe medical records of five patients (eight eyes) with NHOD were reviewed. The ratio of the disc-macula distance to the disc diameter (DM/DD) and the disc ovality ratio of the minimal to maximal DD were assessed using fundus photographs. The RNFL thicknesses of the temporal, superior, nasal, and inferior quadrants were evaluated using OCT quadrant maps...
December 2017: Eye
Neda Baniasadi, Mengyu Wang, Hui Wang, Mufeed Mahd, Tobias Elze
PURPOSE: To evaluate the associations between optic disc (OD)-related anatomical parameters (interartery angle [IAA] between superior and inferior temporal retinal arteries, OD tilt [TL], rotation [ROT], and torsion [TO], OD surface curvature [CUR], and central retinal vessel trunk entry point location [CRVTL] on OD) and the spherical equivalent of refractive error (SE), and to assess the impact of glaucoma severity on these relationships. METHODS: Cirrus optical coherence tomography (OCT) fundus images and 24-2 visual fields of 438 patients were included...
July 2017: Translational Vision Science & Technology
Yong Chan Kim, Younhea Jung, Hae-Young Lopilly Park, Chan Kee Park
Tilted and rotated appearances are hallmarks of the myopic optic disc. As the eyeball grows axially, the posterior pole elongates not only globally but in a localized manner as well. In this process, the optic disc is pulled towards the deepest point of the elongated eyeball, which might result in a change in optic disc configuration. Thus, we hypothesized that analyzing the variation of posterior pole contour can play a major role in understanding optic disc configuration in myopic subjects. By analyzing consecutive images of swept source OCT coronal sections at the posterior pole, the deepest interface between Bruch's membrane and the choroid could be identified as the deepest point of the eyeball (DPE)...
July 19, 2017: Scientific Reports
Wendy L Marsh-Tootle, Elise Harb, Wei Hou, Qinghua Zhang, Heather A Anderson, Katherine Weise, Thomas T Norton, Jane Gwiazda, Leslie Hyman
Purpose: The purpose of this article is to evaluate optic nerve head (ONH) characteristics in an ethnically diverse cohort of young U.S. adults. Methods: In this study, 409 myopes and 206 nonmyopes (median age 22 years) completed measures including biometry and spectral domain optical coherence tomography from enface (ovality and torsion) and cross-sectional (tilt and crescent width) scans. Associated factors were evaluated using multivariable models. Results: In myopic versus nonmyopic right eyes, median tilt (6...
June 1, 2017: Investigative Ophthalmology & Visual Science
Giovanni Taibbi, Ronita L Cromwell, Susana B Zanello, Patrice O Yarbough, Robert J Ploutz-Snyder, Bernard F Godley, Gianmarco Vizzeri
INTRODUCTION: We evaluated ophthalmic changes in healthy individuals who underwent integrated resistance and aerobic training (iRAT) during 70-d 6° head-down tilt (HDT) bed rest (BR). METHODS: Participants were selected using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects were randomly assigned to the iRAT protocol or no exercise during HDTBR. Weekly ophthalmic examinations were performed in the sitting (pre/post-BR only) and HDT (BR only) positions...
July 1, 2017: Aerospace Medicine and Human Performance
Steven S Laurie, Gianmarco Vizzeri, Giovanni Taibbi, Connor R Ferguson, Xiao Hu, Stuart M C Lee, Robert Ploutz-Snyder, Scott M Smith, Sara R Zwart, Michael B Stenger
Many astronauts experience ocular structural and functional changes during long-duration spaceflight, including choroidal folds, optic disc edema, globe flattening, optic nerve sheath diameter (ONSD) distension, retinal nerve fiber layer thickening, and decreased visual acuity. The leading hypothesis suggests that weightlessness-induced cephalad fluid shifts increase intracranial pressure (ICP), which contributes to the ocular structural changes, but elevated ambient CO2 levels on the International Space Station may also be a factor...
June 2017: Physiological Reports
I Lopez-Cuenca, R de Hoz, E Salobrar-Garcia, B Rojas, A I Ramirez, J J Salazar, A Trivino, J M Ramirez
INTRODUCTION: Situs inversus of the optic nerve is a congenital anomaly characterised by the emergence of the vessels in the retina towards the nose rather than in a temporal direction. It is caused by an anomalous insertion of the optic stalks into the optic vesicle that gives rise to dysversion of the head of the optic nerve. It is not an isolated condition and usually appears jointly with tilted disc syndrome and in patients with myopia. It is characterised by the presence of inferior conus atrophy, deficiencies in the temporal visual field, refraction defects and ambliopy...
June 1, 2017: Revista de Neurologia
Yu Sawada, Makoto Araie, Makoto Ishikawa, Takeshi Yoshitomi
PURPOSE: To investigate characteristics of lamina cribrosa (LC) defects in myopic eyes with open-angle glaucoma (OAG) using spectral-domain (SD) optical coherence tomography (OCT). DESIGN: Cross-sectional study. PARTICIPANTS: One hundred thirty-three eyes with OAG and 83 eyes without OAG, with axial length of 24 mm or more. METHODS: Serial enhanced depth imaging SD OCT B-scans of the optic disc were acquired and reviewed for LC defects (diameter, ≥100 μm) and large pores (diameter, 60-100 μm)...
November 2017: Ophthalmology
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