keyword
MENU ▼
Read by QxMD icon Read
search

TAS1R2

keyword
https://www.readbyqxmd.com/read/29679682/bitter-and-sweet-tasting-molecules-it-s-complicated
#1
REVIEW
Antonella Di Pizio, Yaron Ben Shoshan-Galeczki, John E Hayes, Masha Y Niv
"Bitter" and "sweet" are frequently framed in opposition, both functionally and metaphorically, in regard to affective responses, emotion, and nutrition. This oppositional relationship is complicated by the fact that some molecules are simultaneously bitter and sweet. In some cases, a small chemical modification, or a chirality switch, flips the taste from sweet to bitter. Molecules humans describe as bitter are recognized by a 25 member subfamily of class A G-protein coupled receptors (GPCRs) known as TAS2Rs...
April 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29625018/sugar-sensor-genes-in-the-murine-gastrointestinal-tract-display-a-cephalocaudal-axis-of-expression-and-a-diurnal-rhythm
#2
Patrick O'Brien, Rhys Hewett, Christopher Corpe
Distributed along the length of the gastrointestinal (GI) tract are nutrient sensing cells that release numerous signalling peptides influencing GI function, nutrient homeostasis and energy balance. Recent studies have shown a diurnal rhythm in GI nutrient sensing, but the mechanisms responsible for rhythmicity are poorly understood. In this report we studied murine GI sugar sensor gene and protein expression levels in the morning (7am) and evening (7pm). Sweet taste receptor (tas1r2/tas1r3/gnat3/ gnat1) sugar transporter (slc5a1, slc2a2, slc2a5) and putative sugar sensor (slc5a4a and slc5a4b) gene expression levels were highest in tongue, proximal and distal small intestine, respectively...
April 6, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29385734/single-nucleotide-polymorphisms-in-taste-receptor-genes-are-associated-with-snacking-patterns-of-preschool-aged-children-in-the-guelph-family-health-study-a-pilot-study
#3
Elie Chamoun, Joy M Hutchinson, Owen Krystia, Julia A Mirotta, David M Mutch, Andrea C Buchholz, Alison M Duncan, Gerarda Darlington, Jess Haines, David W L Ma
Snacking is an integral component of eating habits in young children that is often overlooked in nutrition research. While snacking is a substantial source of calories in preschoolers' diets, there is limited knowledge about the factors that drive snacking patterns. The genetics of taste may help to better understand the snacking patterns of children. The rs1761667 single nucleotide polymorphism (SNP) in the CD36 gene has been linked to fat taste sensitivity, the rs35874116 SNP in the TAS1R2 gene has been related to sweet taste preference, and the rs713598 SNP in the TAS2R38 gene has been associated with aversion to bitter, green leafy vegetables...
January 30, 2018: Nutrients
https://www.readbyqxmd.com/read/29382185/genetic-variations-in-sweet-taste-receptor-gene-are-related-to-chocolate-powder-and-dietary-fiber-intake-in-obese-children-and-adolescents
#4
Marina B Pioltine, Maria Edna de Melo, Aritânia S Santos, Alisson D Machado, Ariana E Fernandes, Clarissa T Fujiwara, Cintia Cercato, Marcio C Mancini
Childhood obesity is a major public health problem. It has a direct impact on the quality of life of children and adolescents, as well as on their future risk of developing chronic diseases. Dietary patterns rich in fats and sugars and lacking dietary fibers, vitamins, and minerals, as well as lack of physical exercise have been associated with the rise of obesity prevalence. However, factors that contribute to the preference for foods rich in these nutrients are not well established. Taste is recognized as an important predictor of food choices, and polymorphisms in taste-related genes may explain the variability of taste preference and food intake...
January 29, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29122492/d-leucine-evaluation-in-an-epilepsy-model
#5
Kylie Holden, Adam L Hartman
BACKGROUND: Current medicines do not provide sufficient seizure control for nearly one-third of patients with epilepsy. New options are needed to address this treatment gap. We recently found that the atypical amino acid d-leucine protected against acutely-induced seizures in mice, but its effect in chronic seizures has not been explored. We hypothesized that d-leucine would protect against spontaneous recurrent seizures. We also investigated whether mice lacking a previously-described d-leucine receptor (Tas1R2/R3) would be protected against acutely-induced seizures...
January 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29110749/salivary-leptin-and-tas1r2-tas1r3-polymorphisms-are-related-to-sweet-taste-sensitivity-and-carbohydrate-intake-from-a-buffet-meal-in-healthy-young-adults
#6
Pengfei Han, Russell S J Keast, Eugeni Roura
The influence of sweet taste sensitivity on food intake is not well understood. We investigated the involvement of salivary leptin and SNP of the sweet taste receptor genes (TAS1R2/TAS1R3) on sweet taste sensitivity, sensory-specific satiety (SSS) and macronutrient intake in healthy human adults. In all, nineteen high sweet sensitivity (HS) and eleven low sweet sensitivity (LS) subjects were classified based on the sweetness perception of one solution (9 mm sucrose) forced-choice triangle test. All participants completed a randomised crossover design experiment where they consumed one of three iso-energetic soup preloads differing in primary taste quality (sweet, non-sweet taste-control or no-taste energy-control)...
November 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29019082/loss-of-the-nutrient-sensor-tas1r3-leads-to-reduced-bone-resorption
#7
Michael S Eaton, Nicholas Weinstein, Jordan B Newby, Maggie M Plattes, Hanna E Foster, Jon W Arthur, Taylor D Ward, Stephen R Shively, Ryann Shor, Justin Nathan, Hannah M Davis, Lilian I Plotkin, Eric M Wauson, Brian J Dewar, Aaron Broege, Jonathan W Lowery
The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such as L-glycine and L-glutamate or sweet molecules such as sucrose and fructose when dimerized with TAS1R member 1 (TAS1R1) or TAS1R member 2 (TAS1R2), respectively. It was recently reported that deletion of TAS1R3 expression in Tas1R3 mutant mice leads to increased cortical bone mass but the underlying cellular mechanism leading to this phenotype remains unclear...
October 10, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29017172/the-emerging-roles-of-cib1-in-cancer
#8
REVIEW
Xianwang Wang, Xiaochun Peng, Xueqing Zhang, Hanyi Xu, Chengbiao Lu, Lian Liu, Jiaxing Song, Yingjie Zhang
Calcium and integrin-binding protein 1 (CIB1) is an EF-hand calcium binding protein, which is involved in many cellular processes, including calcium signaling, cell survival and proliferation, cell migration, cell adhesion and apoptosis. A number of studies have found that CIB1 is ubiquitously expressed and is related to various human diseases, such as cancer, Alzheimer's disease (AD), cardiac hypertrophy and male infertility. The mechanism of CIB1 in human diseases is still not clear, although multiple functions of CIB1 are modulated by interacting with numerous interacting partners...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28888730/dna-methylation-patterns-at-sweet-taste-transducing-genes-are-associated-with-bmi-and-carbohydrate-intake-in-an-adult-population
#9
O Ramos-Lopez, A Arpón, J I Riezu-Boj, F I Milagro, M L Mansego, J A Martinez
Individual differences in taste perception may influence appetite, dietary intakes, and subsequently, disease risk. Correlations of DNA methylation patterns at taste transducing genes with BMI and dietary intakes were studied. A nutriepigenomic analysis within the Methyl Epigenome Network Association (MENA) project was conducted in 474 adults. DNA methylation in peripheral white blood cells was analyzed by a microarray approach. KEGG pathway analyses were performed concerning the characterization and discrimination of genes involved in the taste transduction pathway...
January 1, 2018: Appetite
https://www.readbyqxmd.com/read/28700634/differential-modulation-of-the-lactisole-sweet-water-taste-by-sweeteners
#10
RANDOMIZED CONTROLLED TRIAL
Cynthia Alvarado, Danielle Nachtigal, Jay P Slack, Barry G Green
Pre-exposure to taste stimuli and certain chemicals can cause water to have a taste. Here we studied further the 'sweet water taste' (SWT) perceived after exposure to the sweet taste inhibitor lactisole. Experiment 1 investigated an incidental observation that presenting lactisole in mixture with sucrose reduced the intensity of the SWT. The results confirmed this observation and also showed that rinsing with sucrose after lactisole could completely eliminate the SWT. The generalizability of these findings was investigated in experiment 2 by presenting 5 additional sweeteners before, during, or after exposure to lactisole...
2017: PloS One
https://www.readbyqxmd.com/read/28497839/evaluation-of-the-association-between-the-tas1r2-and-tas1r3-variants-and-food-intake-and-nutritional-status-in-children
#11
Silvia V Melo, Grasiela Agnes, Márcia R Vitolo, Vanessa S Mattevi, Paula D B Campagnolo, Silvana Almeida
Taste perception plays a key role in determining individual food preferences and dietary habits and may influence nutritional status. This study aimed to investigate the association of TAS1R2 (Ile191Val - rs35874116) and TAS1R3 (-1266 C/T - rs35744813) variants with food intake and nutritional status in children followed from birth until 7.7 years old. The nutritional status and food intake data of 312 children were collected at three developmental stages (1, 3.9 and 7.7 years old). DNA was extracted from blood samples and the polymorphisms were analyzed by real-time polymerase chain reactions (qPCR) using hydrolysis probes as the detection method...
April 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28228527/activation-mechanism-of-the-g-protein-coupled-sweet-receptor-heterodimer-with-sweeteners-and-allosteric-agonists
#12
Soo-Kyung Kim, Yalu Chen, Ravinder Abrol, William A Goddard, Brian Guthrie
The sweet taste in humans is mediated by the TAS1R2/TAS1R3 G protein-coupled receptor (GPCR), which belongs to the class C family that also includes the metabotropic glutamate and γ-aminobutyric acid receptors. We report here the predicted 3D structure of the full-length TAS1R2/TAS1R3 heterodimer, including the Venus Flytrap Domains (VFDs) [in the closed-open (co) active conformation], the cysteine-rich domains (CRDs), and the transmembrane domains (TMDs) at the TM56/TM56 interface. We observe that binding of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6 interface between TMDs of TAS1R2 and TAS1R3, which is consistent with the activation process observed biophysically on the metabotropic glutamate receptor 2 homodimer...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28205335/a-sweet-taste-receptor-dependent-mechanism-of-glucosensing-in-hypothalamic-tanycytes
#13
Heather Benford, Matei Bolborea, Eric Pollatzek, Kristina Lossow, Irm Hermans-Borgmeyer, Beihui Liu, Wolfgang Meyerhof, Sergey Kasparov, Nicholas Dale
Hypothalamic tanycytes are glial-like glucosensitive cells that contact the cerebrospinal fluid of the third ventricle, and send processes into the hypothalamic nuclei that control food intake and body weight. The mechanism of tanycyte glucosensing remains undetermined. While tanycytes express the components associated with the glucosensing of the pancreatic β cell, they respond to nonmetabolisable glucose analogues via an ATP receptor-dependent mechanism. Here, we show that tanycytes in rodents respond to non-nutritive sweeteners known to be ligands of the sweet taste (Tas1r2/Tas1r3) receptor...
May 2017: Glia
https://www.readbyqxmd.com/read/27992462/acute-effects-of-sugars-and-artificial-sweeteners-on-small-intestinal-sugar-transport-a-study-using-caco-2-cells-as-an-in-vitro-model-of-the-human-enterocyte
#14
Patrick O'Brien, Christopher Peter Corpe
BACKGROUND: The gastrointestinal tract is responsible for the assimilation of nutrients and plays a key role in the regulation of nutrient metabolism and energy balance. The molecular mechanisms by which intestinal sugar transport are regulated are controversial. Based on rodent studies, two models currently exist that involve activation of the sweet-taste receptor, T1R2/3: an indirect model, whereby luminal carbohydrates activate T1R2/3 expressed on enteroendocrine cells, resulting in the release of gut peptides which in turn regulate enterocyte sugar transport capacity; and a direct model, whereby T1R2/3 expressed on the enterocyte regulates enterocyte function...
2016: PloS One
https://www.readbyqxmd.com/read/27982108/high-maltose-sensitivity-of-sweet-taste-receptors-in-the-japanese-macaque-macaca-fuscata
#15
Emiko Nishi, Kei Tsutsui, Hiroo Imai
Taste sensitivity differs among animal species depending on feeding habitat. To humans, sucrose is one of the sweetest natural sugars, and this trait is expected to be similar in other primates. However, previous behavioral tests have shown that some primate species have equal preferences for maltose and sucrose. Because sweet tastes are recognized when compounds bind to the sweet taste receptor Tas1R2/Tas1R3, we evaluated the responses of human and Japanese macaque Tas1R2/Tas1R3 to various natural sugars using a heterologous expression system...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27956941/accumulation-of-intestinal-tissue-3-deoxyglucosone-attenuated-glp-1-secretion-and-its-insulinotropic-effect-in-rats
#16
Lurong Zhang, Xiudao Song, Liang Zhou, Guoqiang Liang, Heng Xu, Fei Wang, Fei Huang, Guorong Jiang
BACKGROUND: Our recent findings support the idea that 3-deoxyglucosone (3DG), a dietary composition, has been suggested as an independent factor for the development of prediabetes. Secretion of glucagon-like peptide-1 (GLP-1) has been suggested to be impaired in T2DM and in conditions associated with hyperglycemia. Since low oral bioavailability of 3DG has been indicated in a single administration study, in the present study we examined if 3DG is capable of accumulating in intestinal tissue of rats after 2-week administration of 3DG, and the 3DG treatment affects GLP-1 secretion and glucose tolerance...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27479072/characterization-of-the-sweet-taste-receptor-tas1r2-from-an-old-world-monkey-species-rhesus-monkey-and-species-dependent-activation-of-the-monomeric-receptor-by-an-intense-sweetener-perillartine
#17
Chenggu Cai, Hua Jiang, Lei Li, Tianming Liu, Xuejie Song, Bo Liu
Sweet state is a basic physiological sensation of humans and other mammals which is mediated by the broadly acting sweet taste receptor-the heterodimer of Tas1r2 (taste receptor type 1 member 2) and Tas1r3 (taste receptor type 1 member 3). Various sweeteners interact with either Tas1r2 or Tas1r3 and then activate the receptor. In this study, we cloned, expressed and functionally characterized the taste receptor Tas1r2 from a species of Old World monkeys, the rhesus monkey. Paired with the human TAS1R3, it was shown that the rhesus monkey Tas1r2 could respond to natural sugars, amino acids and their derivates...
2016: PloS One
https://www.readbyqxmd.com/read/27162343/taste-cell-expressed-%C3%AE-glucosidase-enzymes-contribute-to-gustatory-responses-to-disaccharides
#18
Sunil K Sukumaran, Karen K Yee, Shusuke Iwata, Ramana Kotha, Roberto Quezada-Calvillo, Buford L Nichols, Sankar Mohan, B Mario Pinto, Noriatsu Shigemura, Yuzo Ninomiya, Robert F Margolskee
The primary sweet sensor in mammalian taste cells for sugars and noncaloric sweeteners is the heteromeric combination of type 1 taste receptors 2 and 3 (T1R2+T1R3, encoded by Tas1r2 and Tas1r3 genes). However, in the absence of T1R2+T1R3 (e.g., in Tas1r3 KO mice), animals still respond to sugars, arguing for the presence of T1R-independent detection mechanism(s). Our previous findings that several glucose transporters (GLUTs), sodium glucose cotransporter 1 (SGLT1), and the ATP-gated K(+) (KATP) metabolic sensor are preferentially expressed in the same taste cells with T1R3 provides a potential explanation for the T1R-independent detection of sugars: sweet-responsive taste cells that respond to sugars and sweeteners may contain a T1R-dependent (T1R2+T1R3) sweet-sensing pathway for detecting sugars and noncaloric sweeteners, as well as a T1R-independent (GLUTs, SGLT1, KATP) pathway for detecting monosaccharides...
May 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27010324/a-comparison-of-collection-techniques-for-gene-expression-analysis-of-human-oral-taste-tissue
#19
COMPARATIVE STUDY
Nicholas Steven Archer, Dongli Liu, Jan Shaw, Garry Hannan, Konsta Duesing, Russell Keast
Variability in human taste perception is associated with both genetic and environmental factors. The influence of taste receptor expression on this variability is unknown, in part, due to the difficulty in obtaining human oral tissue that enables quantitative expression measures of taste genes. In a comparison of six current techniques (Oragene RNeasy Kit, Isohelix swab, Livibrush cytobrush, tongue saliva, cheek saliva collection, and fungiform papillae biopsy), we identify the fungiform papillae biopsy is the optimal sampling technique to analyse human taste gene expression...
2016: PloS One
https://www.readbyqxmd.com/read/26960429/intracellular-acidification-is-required-for-full-activation-of-the-sweet-taste-receptor-by-miraculin
#20
Keisuke Sanematsu, Masayuki Kitagawa, Ryusuke Yoshida, Satoru Nirasawa, Noriatsu Shigemura, Yuzo Ninomiya
Acidification of the glycoprotein, miraculin (MCL), induces sweet taste in humans, but not in mice. The sweet taste induced by MCL is more intense when acidification occurs with weak acids as opposed to strong acids. MCL interacts with the human sweet receptor subunit hTAS1R2, but the mechanisms by which the acidification of MCL activates the sweet taste receptor remain largely unexplored. The work reported here speaks directly to this activation by utilizing a sweet receptor TAS1R2 + TAS1R3 assay. In accordance with previous data, MCL-applied cells displayed a pH dependence with citric acid (weak acid) being right shifted to that with hydrochloric acid (strong acid)...
March 10, 2016: Scientific Reports
keyword
keyword
4845
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"