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https://www.readbyqxmd.com/read/29626214/cryptic-glucocorticoid-receptor-binding-sites-pervade-genomic-nf-%C3%AE%C2%BAb-response-elements
#1
William H Hudson, Ian Mitchelle S de Vera, Jerome C Nwachukwu, Emily R Weikum, Austin G Herbst, Qin Yang, David L Bain, Kendall W Nettles, Douglas J Kojetin, Eric A Ortlund
Glucocorticoids (GCs) are potent repressors of NF-κB activity, making them a preferred choice for treatment of inflammation-driven conditions. Despite the widespread use of GCs in the clinic, current models are inadequate to explain the role of the glucocorticoid receptor (GR) within this critical signaling pathway. GR binding directly to NF-κB itself-tethering in a DNA binding-independent manner-represents the standing model of how GCs inhibit NF-κB-driven transcription. We demonstrate that direct binding of GR to genomic NF-κB response elements (κBREs) mediates GR-driven repression of inflammatory gene expression...
April 6, 2018: Nature Communications
https://www.readbyqxmd.com/read/29600888/genetic-variation-of-candidatus-liberibacter-solanacearum-haplotype-c-and-identification-of-a-novel-haplotype-from-trioza-urticae-and-stinging-nettle
#2
Minna L Haapalainen, Jinhui Wang, Satu Latvala, Mikko T Lehtonen, Minna Pirhonen, Anne I Nissinen
'Candidatus Liberibacter solanacearum' (CLso) haplotype C is associated with disease in carrots and transmitted by the carrot psyllid Trioza apicalis. To identify possible other sources and vectors of this pathogen in Finland, samples were taken of wild plants within and near the carrot fields, the psyllids feeding on these plants, parsnips growing next to carrots, and carrot seeds. For analyzing the genotype of the CLso positive samples, a multi-locus sequence typing (MLST) scheme was developed. CLso haplotype C was detected in 11% of the Trioza anthrisci samples, in 35% of the Anthriscus sylvestris plants with discoloration, and in parsnips showing leaf discoloration...
March 30, 2018: Phytopathology
https://www.readbyqxmd.com/read/29564116/determination-of-some-quality-properties-of-hamsi-kaygana-prepared-with-different-additives
#3
Latif Taşkaya, Elif Yaşar
This study was aimed to determine the changes of the local anchovy meal which is known as hamsi kaygana in Turkey during cold storage at +4°C ± 1°C. Physicochemical (pH, TVB-N, TMA-N, and TBA) shelf life analyses were carried out for hamsi kaygana samples. It was confirmed that the pH values obtained from research groups were within the limit values of the literature. No statistically significant difference was observed ( p  > .05) between control, stinging nettle, and rosemary groups that were within all created product groups on 12th day of storage, and the observed difference was only present in cumin group ( p  < ...
March 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/29544228/lipid-nanocarriers-for-oral-delivery-of-serenoa-repens-co2-extract-a-study-of-microemulsion-and-self-microemulsifying-drug-delivery-systems
#4
Clizia Guccione, Maria Camilla Bergonzi, Khaled M Awada, Vieri Piazzini, Anna Rita Bilia
The aim of this study was the development and characterization of lipid nanocarriers using food grade components for oral delivery of Serenoa repens CO2 extract, namely microemulsions (MEs) and self-microemulsifying drug delivery systems (SMEDDSs) to improve the oral absorption. A commercial blend (CB) containing 320 of S. repens CO2 extract plus the aqueous soluble extracts of nettle root and pineapple stem was formulated in two MEs and two SMEDDSs. The optimized ME loaded with the CB (CBM2) had a very low content of water (only 17...
March 15, 2018: Planta Medica
https://www.readbyqxmd.com/read/29518971/dietary-plants-for-the-prevention-and-management-of-kidney-stones-preclinical-and-clinical-evidence-and-molecular-mechanisms
#5
REVIEW
Mina Cheraghi Nirumand, Marziyeh Hajialyani, Roja Rahimi, Mohammad Hosein Farzaei, Stéphane Zingue, Seyed Mohammad Nabavi, Anupam Bishayee
Kidney stones are one of the oldest known and common diseases in the urinary tract system. Various human studies have suggested that diets with a higher intake of vegetables and fruits play a role in the prevention of kidney stones. In this review, we have provided an overview of these dietary plants, their main chemical constituents, and their possible mechanisms of action. Camellia sinensis (green tea), Rubus idaeus (raspberry), Rubia cordifolia (common madder), Petroselinum crispum (parsley), Punica granatum (pomegranate), Pistacia lentiscus (mastic), Solanum xanthocarpum (yellow-fruit nightshade), Urtica dioica (stinging nettle), Dolichos biflorus ( horse gram ), Ammi visnaga (khella), Nigella sativa (black-cumin), Hibiscus sabdariffa (roselle), and Origanum vulgare (oregano) have received considerable interest based on scientific evidence...
March 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29518723/effects-of-forest-based-bioenergy-feedstock-production-on-shallow-groundwater-quality-of-a-drained-forest-soil
#6
Julian F Cacho, Mohamed A Youssef, George M Chescheir, R Wayne Skaggs, Timothy W Appelboom, Zakiya H Leggett, Eric B Sucre, Jami E Nettles, Consuelo Arellano
Managed forests in southern U.S. are a potential source of lignocellulosic biomass for biofuel production. Changes in management practices to optimize biomass production may impact the quality of waters draining to nutrient-sensitive waters in coastal plain regions. We investigated shallow groundwater quality effects of intercropping switchgrass (Panicum virgatum L.) with managed loblolly pine (Pinus taeda L.) to produce bioenergy feedstock and quality sawtimber in a poorly drained soil of eastern North Carolina, U...
March 5, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29472625/the-role-of-medial-prefrontal-cortex-in-the-working-memory-maintenance-of-one-s-own-emotional-responses
#7
Ryan Smith, Richard D Lane, Anna Alkozei, Jennifer Bao, Courtney Smith, Anna Sanova, Matthew Nettles, William D S Killgore
The role of medial prefrontal cortex (MPFC) in maintaining emotional information within working memory (WM) remains insufficiently investigated - with some studies suggesting this process activates MPFC and others suggesting its activity is suppressed. To reconcile these different results, we asked 26 healthy participants to complete a WM task involving the maintenance of emotional content (EWM), visual content (VWM), or no content ("rest") after exposure to emotion-provoking images. We also assessed individual differences in emotional awareness (EA)...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29421223/state-dependent-cognition-and-its-relevance-to-cultural-evolution
#8
REVIEW
Daniel Nettle
Individuals cope with their worlds by using information. In humans in particular, an important potential source of information is cultural tradition. Evolutionary models have examined when it is advantageous to use cultural information, and psychological studies have examined the cognitive biases and priorities that may transform cultural traditions over time. However, these studies have not generally incorporated the idea that individuals vary in state. I argue that variation in state is likely to influence the relative payoffs of using cultural information versus gathering personal information; and also that people in different states will have different cognitive biases and priorities, leading them to transform cultural information in different ways...
February 5, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29411721/effect-of-a-galactagogue-herbal-tea-on-breast-milk-production-and-prolactin-secretion-by-mothers-of-preterm-babies
#9
E Özalkaya, Z Aslandoğdu, A Özkoral, S Topcuoğlu, G Karatekin
BACKGROUND AND OBJECTIVES: Poor breast milk production is the most frequent cause of breastfeeding failure in preterm babies. The aim of our study is to evaluate the effect of herbal tea mixture containing stinging nettle (Natal, Hipp) on breast milk production and serum prolactin levels of mothers, and weight gain of preterm babies. MATERIALS AND METHODS: We enrolled mothers and their babies who were less than 37 gestational week and less than 2000 g, fed with orogastric tube without any contraindication of enteral feeding in neonatal intensive care unit between November 2010 and June 2011...
January 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29385988/a-patient-and-family-data-domain-collection-framework-for-identifying-disparities-in-pediatrics-results-from-the-pediatric-health-equity-collaborative
#10
Aswita Tan-McGrory, Caroline Bennett-AbuAyyash, Stephanie Gee, Kirk Dabney, John D Cowden, Laura Williams, Sarah Rafton, Arie Nettles, Sonia Pagura, Laurens Holmes, Jane Goleman, LaVone Caldwell, James Page, Patricia Oceanic, Erika J McMullen, Adriana Lopera, Sarah Beiter, Lenny López
BACKGROUND: By 2020, the child population is projected to have more racial and ethnic minorities make up the majority of the populations and health care organizations will need to have a system in place that collects accurate and reliable demographic data in order to monitor disparities. The goals of this group were to establish sample practices, approaches and lessons learned with regard to race, ethnicity, language, and other demographic data collection in pediatric care setting. METHODS: A panel of 16 research and clinical professional experts working in 10 pediatric care delivery systems in the US and Canada convened twice in person for 3-day consensus development meetings and met multiple times via conference calls over a two year period...
January 31, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29359438/mothers-groups-enrich-diet-and-culture-through-promoting-traditional-quichua-foods
#11
Marion L Roche, Lorena Ambato, Julieta Sarsoza, Harriet V Kuhnlein
Indigenous Peoples in Latin America bear a disproportionate burden of undernutrition, yet traditional foods, including wild leafy greens, can contribute nutritional value to diets. As part of a community nutrition intervention using local foods in highland Tungurahua, Ecuador, mothers' groups promoted the consumption of wild leafy greens through community cooking clubs and recipe competitions at local fairs. The objective was to assess the social, cultural, and nutritional potential of a mothers' club intervention that promoted 2 indigenous greens (stinging nettle/Urtica dioica L...
November 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29340251/the-relationships-between-exercise-and-affective-states-a-naturalistic-longitudinal-study-of-recreational-runners
#12
Tim Bonham, Gillian V Pepper, Daniel Nettle
Background: Although people generally feel more positive and more energetic in the aftermath of exercise than before, longitudinal research on how exercise relates to within-person fluctuations in affect over the course of everyday life is still relatively limited. One constraint on doing such research is the need to provide participants with accelerometers to objectively record their exercise, and pagers to capture affective reports. Aims: We aimed to develop a methodology for studying affect and exercise using only technology that participants already possess, namely GPS running watches and smartphones...
2018: PeerJ
https://www.readbyqxmd.com/read/29335363/why-are-there-associations-between-telomere-length-and-behaviour
#13
REVIEW
Melissa Bateson, Daniel Nettle
Individual differences in telomere length are associated with individual differences in behaviour in humans and birds. Within the human epidemiological literature this association is assumed to result from specific behaviour patterns causing changes in telomere dynamics. We argue that selective adoption-the hypothesis that individuals with short telomeres are more likely to adopt specific behaviours-is an alternative worthy of consideration. Selective adoption could occur either because telomere length directly affects behaviour or because behaviour and telomere length are both affected by a third variable, such as exposure to early-life adversity...
March 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29278868/linear-rheology-as-a-potential-monitoring-tool-for-sputum-in-patients-with-chronic-obstructive-pulmonary-disease-copd
#14
C J Nettle, L Jenkins, D Curtis, N Badiei, K Lewis, P R Williams, D R Daniels
BACKGROUND: The rheological properties of sputum may influence lung function and become modified in disease. OBJECTIVE: This study aimed to correlate the viscoelastic properties of sputum with clinical data on the severity of disease in patients with chronic obstructive pulmonary disease (COPD). METHODS: Sputum samples from COPD patients were investigated using rheology, simple mathematical modelling and Scanning Electron Microscopy (SEM)...
2018: Biorheology
https://www.readbyqxmd.com/read/29228792/silymarin-olibanum-and-nettle-a-mixed-herbal-formulation-in-the-treatment-of-type-ii-diabetes-a-randomized-double-blind-placebo-controlled-clinical-trial
#15
Nahid Khalili, Reza Fereydoonzadeh, Reza Mohtashami, Saeed Mehrzadi, Mojtaba Heydari, Hasan Fallah Huseini
Silybum marianum (L) Gaertn (milk thistle) seeds, Urtica dioica L (nettle) leaves, and Boswellia serrata (olibanum gum) resin are used traditionally by Iranian diabetic patients. The aim of this study was to evaluate the antihyperglycemic effects of these herbs in an herbal formulation in patients with type II diabetes mellitus. Sixty patients diagnosed as type II diabetes mellitus with fasting blood glucose level from 150 to 180 mg/dL, glycosylated hemoglobin level from 7.5% to 8.5%, and on oral antihyperglycemic drugs, were allocated to receive the mix herbal formulation or placebo for 90 days in a double-blind randomized placebo-controlled clinical trial...
October 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29211914/stinging-nettle-and-neem-enhance-antibody-response-to-local-killed-and-imported-live-infectious-bursal-disease-vaccines-in-indigenous-chicken-in-kenya
#16
M O Bwana, L W Njagi, P N Nyaga, P G Mbuthia, L C Bebora, M W Wahome, W U Mutinda, P M Kitala
Immune responses are critical for protection of chickens from infectious bursal disease (IBD). In this study, the antibody response-enhancing effect of drinking water supplementation of 1% stinging nettle and neem on different IBD vaccines and vaccination regimes was evaluated, using 36 (n = 36) specific antibody negative indigenous chicks. The birds were allocated into 3 groups as follows: 1A-C, 2A-C, and 3A-B, while group 3C acted as the unvaccinated non-supplemented control. A local inactivated K1 and imported live attenuated D78 IBD vaccines were given to groups 1A-C and 3A-B at 14 and 28 d of age, respectively...
February 1, 2018: Poultry Science
https://www.readbyqxmd.com/read/29204478/data-of-furfural-adsorption-on-nano-zero-valent-iron-nzvi-synthesized-from-nettle-extract
#17
Mehdi Fazlzadeh, Mohammad Ansarizadeh, Mostafa Leili
Among various water and wastewater treatment methods, adsorption techniques are widely used to remove certain classes of pollutants due to its unique features. Thus, the aim of this data article is to synthesize zero valent iron nanoparticles (NZVI) from Nettle leaf extract by green synthesis method as an environmentally friendly technique, and to evaluate it's efficiency in the removal of furfural from aqueous solutions. The data of possible adsorption mechanism and isotherm of furfural on the synthesized adsorbent are depicted in this data article...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29162185/external-environmental-and-internal-health-early-life-predictors-of-adolescent-development
#18
Sarah Hartman, Zhi Li, Daniel Nettle, Jay Belsky
A wealth of evidence documents associations between various aspects of the rearing environment and later development. Two evolutionary-inspired models advance explanations for why and how such early experiences shape later functioning: (a) the external-prediction model, which highlights the role of the early environment (e.g., parenting) in regulating children's development, and (b) the internal-prediction model, which emphasizes internal state (i.e., health) as the critical regulator. Thus, by using data from the NICHD Study of Early Child Care and Youth Development, the current project draws from both models by investigating whether the effect of the early environment on later adolescent functioning is subject to an indirect effect by internal-health variables...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29149858/famine-food-of-vegetal-origin-consumed-in-the-netherlands-during-world-war-ii
#19
Tom Vorstenbosch, Ingrid de Zwarte, Leni Duistermaat, Tinde van Andel
BACKGROUND: Periods of extreme food shortages during war force people to eat food that they normally do not consider edible. The last time that countries in Western Europe experienced severe scarcities was during World War II. The so-called Dutch famine or Hunger Winter (1944-1945) made at least 25,000 victims. The Dutch government took action by opening soup kitchens and providing information on wild plants and other famine food sources in "wartime cookbooks." The Dutch wartime diet has never been examined from an ethnobotanical perspective...
November 17, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29141200/phosgene-oxime-injury-and-associated-mechanisms-compared-to-vesicating-agents-sulfur-mustard-and-lewisite
#20
Dinesh Giri Goswami, Rajesh Agarwal, Neera Tewari-Singh
Phosgene Oxime (CX, Cl2 CNOH), a halogenated oxime, is a potent chemical weapon that causes immediate acute injury and systemic effects. CX, grouped together with vesicating agents, is an urticant or nettle agent with highly volatile, reactive, corrosive, and irritating vapor, and has considerably different chemical properties and toxicity compared to other vesicants. CX is absorbed quickly through clothing with faster cutaneous penetration compared to other vesicating agents causing instantaneous and severe damage...
November 12, 2017: Toxicology Letters
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