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https://www.readbyqxmd.com/read/28912408/-results-of-a-drug-use-survey-of-filgrastim-biosimilar-1-filgrastim-bs-syringe-for-inj-mochida-and-f
#1
Tsukasa Teshima, Nao Takigawa, Yuki Makita, Chinatsu Kushiya
With the aim of evaluating the safety and efficacy of filgrastim biosimilar 1(Filgrastim BS syringe for Inj. "MOCHIDA"and "F"), we conducted a drug use results survey of this product for its indications, including mobilization of hematopoietic stem cells into peripheral blood and chemotherapy-induced neutropenia. Of the 518 cases enrolled between August 2013 and July 2015, 495 were selected to be subjects of our safety and efficacy evaluations. 37 cases (7.47%)experienced side effects, which were mainly lower back pain(19, 3...
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28904064/structurally-novel-antiestrogens-elicit-differential-responses-from-constitutively-active-mutant-estrogen-receptors-in-breast-cancer-cells-and-tumors
#2
Benita S Katzenellenbogen, Yuechao Zhao, Mary J Laws, Valeria Sanabria Guillen, Yvonne Ziegler, Jian Min, Abhishek Sharma, Sung Hoon Kim, David Chu, Ben Ho Park, Steffi Oesterreich, Chengjian Mao, David J Shapiro, Kendall W Nettles, John A Katzenellenbogen
Many ERα-positive breast cancers develop resistance to endocrine therapy via mutation of estrogen receptors (ER) whose constitutive activation is associated with shorter patient survival. Because there is now a clinical need for new antiestrogens (AE) against these mutant ER, we describe here our development and characterization of three chemically novel AE that effectively suppress proliferation of breast cancer cells and tumors. Our AE are effective against wild type and Y537S and D538G ER, the two most commonly occurring constitutively active ER...
September 13, 2017: Cancer Research
https://www.readbyqxmd.com/read/28891711/time-dependent-effects-on-synovial-fluid-composition-during-the-acute-phase-of-human-intra-articular-ankle-fracture
#3
Samuel B Adams, Rachel M Reilly, Janet L Huebner, Virginia B Kraus, Dana L Nettles
BACKGROUND: The study objective was to examine the effect of time and fracture severity on the undiluted synovial fluid (SF) microenvironment during the acute phase following intra-articular fracture (IAF) of the human ankle. METHODS: Ankle SF from 54 patients with an acute IAF was analyzed for concentrations of 10 cytokines, 5 matrix metalloproteinases, 2 products of cartilage catabolism, and combined products of heme metabolism. All analytes were correlated with time from fracture and further analyzed for an effect of 3 time subgroups (0-2 days, 3-9 days, and ≥10 days) corresponding to timepoints for clinical ankle fracture interventions...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28869127/patient-centered-assessment-of-the-value-of-oral-contrast-material
#4
Sean A Woolen, Katherine E Maturen, Ashley Nettles, Shannon Cahalan, Kelly Parent, Diana Gomez-Hassan, Matthew S Davenport
PURPOSE: The aim of this study was to measure the value of oral contrast material from the patient's point of view. METHODS: A prospective HIPAA-compliant survey was administered from August 30, 2016, to March 9, 2017, at two outpatient centers to consecutive outpatients immediately after oral contrast material consumption for abdominopelvic CT. The survey included validated measures of temporary health disutility and oral contrast-specific questions vetted by patient advocates with experience in survey design...
August 28, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28843876/2d-ftir-correlation-spectroscopy-and-epr-analysis-of-urtica-dioica-leaves-from-areas-of-different-environmental-pollution
#5
Paulina Moskal, Aleksandra Wesełucha-Birczyńska, Maria Łabanowska, Magdalena Kurdziel, Maria Filek
Leaves of Urtica dioica collected from two areas of different environmental pollution were analysed by fourier transform infrared spectroscopy (FTIR) and electron paramagnetic resonance (EPR) spectroscopy. Analysis of FTIR spectra allows to describe main component of plant like proteins, lipids and carbohydrates. Although the FTIR spectra of plants from these two geographical locations of different environmental pollution appear to be relatively similar, 2D correlation shows completely different patterns. Synchronous and asynchronous correlation maps showed sequences of changes occurring during development of plant, manly in Amide I and Amide II, lignin, lipids and cellulose...
August 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28837861/klotho-regulates-postnatal-neurogenesis-and-protects-against-age-related-spatial-memory-loss
#6
Ann M Laszczyk, Stephanie Fox-Quick, Hai T Vo, Dailey Nettles, Phyllis C Pugh, Linda Overstreet-Wadiche, Gwendalyn D King
Although the absence of the age-regulating klotho protein causes klotho-deficient mice to rapidly develop cognitive impairment and increasing klotho enhances hippocampal-dependent memory, the cellular effects of klotho that mediate hippocampal-dependent memory function are unknown. Here, we show premature aging of the klotho-deficient hippocampal neurogenic niche as evidenced by reduced numbers of neural stem cells, decreased proliferation, and impaired maturation of immature neurons. Klotho-deficient neurospheres show reduced proliferation and size that is rescued by supplementation with shed klotho protein...
July 29, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28767015/dependency-traits-relationship-power-and-health-risks-in-women-receiving-sexually-transmitted-infection-clinic-services
#7
Eric G Benotsch, Ashlee N Sawyer, Aaron M Martin, Elizabeth S Allen, Christopher D Nettles, Doug Richardson, Cornelis A Rietmeijer
In prior research, having traits consistent with a personality disorder has been shown to be related to substance use and high-risk sexual activity; however, few studies have examined relationships between dependency traits and health-jeopardizing behaviors. Individuals with traits consistent with dependent personality disorder may be more likely to be in a primary relationship characterized by unhealthy conditions, including physical abuse from a partner, low assertiveness in sexual situations, and partner infidelity...
July 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28761784/the-influence-of-mortality-and-socioeconomic-status-on-risk-and-delayed-rewards-a-replication-with-british-participants
#8
Gillian V Pepper, D Helen Corby, Rachel Bamber, Holly Smith, Nicky Wong, Daniel Nettle
Here, we report three attempts to replicate a finding from an influential psychological study (Griskevicius et al., 2011b). The original study found interactions between childhood SES and experimental mortality-priming condition in predicting risk acceptance and delay discounting outcomes. The original study used US student samples. We used British university students (replication 1) and British online samples (replications 2 and 3) with a modified version of the original priming material, which was tailored to make it more credible to a British audience...
2017: PeerJ
https://www.readbyqxmd.com/read/28674669/childhood-and-adult-socioeconomic-position-interact-to-predict-health-in-mid-life-in-a-cohort-of-british-women
#9
Daniel Nettle, Melissa Bateson
BACKGROUND: Low childhood socioeconomic position (cSEP) is associated with poorer adult health, even after adult socioeconomic position (aSEP) is adjusted for. However, whether cSEP and aSEP combine additively or non-additively in predicting adult health is less well studied. Some evidence suggests that the combination of low cSEP and low aSEP is associated with worse health than would be predicted from the sum of their individual effects. METHODS: Using data from female members of the British National Child Development Study cohort, we developed continuous quantitative measures of aSEP and cSEP, and used these to predict self-rated health at ages 23, 33, and 42...
2017: PeerJ
https://www.readbyqxmd.com/read/28657320/adamantyl-antiestrogens-with-novel-side-chains-reveal-a-spectrum-of-activities-in-suppressing-estrogen-receptor-mediated-activities-in-breast-cancer-cells
#10
Jian Min, Valeria Sanabria Guillen, Abhishek Sharma, Yuechao Zhao, Yvonne Ziegler, Ping Gong, Christopher G Mayne, Sathish Srinivasan, Sung Hoon Kim, Kathryn E Carlson, Kendall W Nettles, Benita S Katzenellenbogen, John A Katzenellenbogen
To search for new antiestrogens more effective in treating breast cancers, we explored alternatives to the acrylic acid side chain used in many antiestrogens. To facilitate our search, we used a simple adamantyl ligand core that by avoiding stereochemical issues enabled rapid synthesis of acrylate ketone, ester, and amide analogs. All compounds were high affinity estrogen receptor α (ERα) ligands but displayed a range of efficacies and potencies as antiproliferative and ERα-downregulating agents. There were large differences in activity between compounds having minor structural changes, but antiproliferative and ERα-downregulating efficacies generally paralleled one another...
July 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28655702/antioxidant-and-wound-healing-potential-of-saponins-extracted-from-the-leaves-of-algerian-urtica-dioica-l
#11
Laoufi Razika, Affif Chaouche Thanina, Chebouti-Meziou Nadjiba, Benhabyles Narimen, Dahmani Mohamed Mahdi, Arab Karim
The Nettle is a herbaceous and vivace plant of Asian origin. It is integrated in several areas especially alimentary, agricultural, industrial and medicinal. The aim of this work is to demonstrate through pharmacological tests a possible antioxidant and wound healing effect of crude saponins of the leaves of Urtica dioica L. The extraction method is based on the degree of solubility of saponins in organic solvents. The antioxidant activity of the leaves extracts was evaluated by the diphenyl-picryl-hydrazyl test (DPPH)...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28614869/a-rosa-canina-urtica-dioica-harpagophytum-procumbens-zeyheri-combination-significantly-reduces-gonarthritis-symptoms-in-a-randomized-placebo-controlled-double-blind-study
#12
Margret Moré, Joerg Gruenwald, Ute Pohl, Ralf Uebelhack
The special formulation MA212 (Rosaxan) is composed of rosehip (Rosa canina L.) puree/juice concentrate, nettle (Urtica dioica L.) leaf extract, and devil's claw (Harpagophytum procumbens DC. ex Meisn. or Harpagophytum zeyheri Decne.) root extract and also supplies vitamin D. It is a food for special medical purposes ([EU] No 609/2013) for the dietary management of pain in patients with gonarthritis.This 12-week randomized, placebo-controlled double-blind parallel-design study aimed to investigate the efficacy and safety of MA212 versus placebo in patients with gonarthritis...
June 14, 2017: Planta Medica
https://www.readbyqxmd.com/read/28591827/tethering-not-required-the-glucocorticoid-receptor-binds-directly-to-activator-protein-1-recognition-motifs-to-repress-inflammatory-genes
#13
Emily R Weikum, Ian Mitchelle S de Vera, Jerome C Nwachukwu, William H Hudson, Kendall W Nettles, Douglas J Kojetin, Eric A Ortlund
The glucocorticoid receptor (GR) is a ligand-regulated transcription factor that controls the expression of extensive gene networks, driving both up- and down-regulation. GR utilizes multiple DNA-binding-dependent and -independent mechanisms to achieve context-specific transcriptional outcomes. The DNA-binding-independent mechanism involves tethering of GR to the pro-inflammatory transcription factor activator protein-1 (AP-1) through protein-protein interactions. This mechanism has served as the predominant model of GR-mediated transrepression of inflammatory genes...
August 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28544187/chemical-composition-and-immuno-modulatory-effects-of-urtica-dioica-l-stinging-nettle-extracts
#14
Marina Francišković, Raquel Gonzalez-Pérez, Dejan Orčić, Fermín Sánchez de Medina, Olga Martínez-Augustin, Emilija Svirčev, Nataša Simin, Neda Mimica-Dukić
The purpose of this work was to determine the chemical profile of stinging nettle and to provide an insight into the mechanisms by which it ameliorates the immune response. Qualitative and quantitative liquid chromatography tandem mass spectrometry analyses indicated that phenolic acids (5-O-caffeoylquinic acid as dominant) and flavonol glycosides (rutin, isoquercitrin, and kaempferol 3-O-glucoside) are present in the aerial parts, while lignans (secoisolariciresinol, 9,9'-bisacetyl-neo-olivil and their glucosides) were detected in the root...
August 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28514424/corrigendum-full-antagonism-of-the-estrogen-receptor-without-a-prototypical-ligand-side-chain
#15
Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Venkatasubramanian Dharmarajan, Devrishi Goswami, Irida Kastrati, Scott Novick, Jason Nowak, Valerie Cavett, Hai-Bing Zhou, Nittaya Boonmuen, Yuechao Zhao, Jian Min, Jonna Frasor, Benita S Katzenellenbogen, Patrick R Griffin, John A Katzenellenbogen, Kendall W Nettles
No abstract text is available yet for this article.
May 17, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28514419/erratum-full-antagonism-of-the-estrogen-receptor-without-a-prototypical-ligand-side-chain
#16
Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Venkatasubramanian Dharmarajan, Devrishi Goswami, Irida Kastrati, Scott Novick, Jason Nowak, Valerie Cavett, Hai-Bing Zhou, Nittaya Boonmuen, Yuechao Zhao, Jian Min, Jonna Frasor, Benita S Katzenellenbogen, Patrick R Griffin, John A Katzenellenbogen, Kendall W Nettles
No abstract text is available yet for this article.
May 17, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28482306/mapping-allergenic-pollen-vegetation-in-uk-to-study-environmental-exposure-and-human-health
#17
Rachel N McInnes, Deborah Hemming, Peter Burgess, Donna Lyndsay, Nicholas J Osborne, Carsten Ambelas Skjøth, Sam Thomas, Sotiris Vardoulakis
Allergenic pollen is produced by the flowers of a number of trees, grasses and weeds found throughout the UK. Exposure to such pollen grains can exacerbate pollen-related asthma and allergenic conditions such as allergic rhinitis (hay fever). Maps showing the location of these allergenic taxa have many applications: they can be used to provide advice on risk assessments; combined with health data to inform research on health impacts such as respiratory hospital admissions; combined with weather data to improve pollen forecasting systems; or as inputs to pollen emission models...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28462056/detecting-telomere-elongation-in-longitudinal-datasets-analysis-of-a-proposal-by-simons-stulp-and-nakagawa
#18
Daniel Nettle, Melissa Bateson
Telomere shortening has emerged as an important biomarker of aging. Longitudinal studies consistently find that, although telomere length shortens over time on average, there is a subset of individuals for whom telomere length is observed to increase. This apparent lengthening could either be a genuine biological phenomenon, or simply due to measurement and sampling error. Simons, Stulp & Nakagawa (2014) recently proposed a statistical test for detecting when the amount of apparent lengthening in a dataset exceeds that which should be expected due to error, and thus indicating that genuine elongation may be operative in some individuals...
2017: PeerJ
https://www.readbyqxmd.com/read/28443364/green-synthesis-of-nano-zero-valent-iron-from-nettle-and-thyme-leaf-extracts-and-their-application-for-the-removal-of-cephalexin-antibiotic-from-aqueous-solutions
#19
Mostafa Leili, Mehdi Fazlzadeh, Amit Bhatnagar
In this study, the removal of cephalexin (CEX) antibiotic from aqueous solution was examined using a novel green adsorbent without employing any toxic chemicals or capping agents. Nettle and Thyme extracts were used to synthesize novel nano-zero-valent iron (NNZVI and TNZVI) for the adsorption of CEX. The nature and morphology of synthesized adsorbent were characterized by Transmission electron microscopy, scanning electron microscope, X-ray diffraction and Fourier transform infrared spectroscopy spectroscopy...
May 12, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28403798/treating-older-hiv-1-infected-subjects-with-cobicistat-boosted-darunavir-in-a-48-week-phase-3-trial
#20
Kimberley Brown, Brooke Patterson-Browning, Chris Liu, Meera Patel, Lisa Stewart, Richard E Nettles
BACKGROUND: An aging HIV-1-infected population warrants examination of the acceptability of individual antiretroviral regimens. In a previous study of ritonavir-boosted darunavir (ARTEMIS), similar safety/efficacy profiles were observed in younger (≤45 years) and older (>45 years) HIV-1-infected subjects. OBJECTIVE: To evaluate safety and efficacy outcomes in HIV-1-infected younger versus older subjects treated with cobicistat-boosted darunavir. METHOD: In a 48-week, phase 3b, open-label trial, HIV-1-infected adults were administered darunavir 800 mg and cobicistat 150 mg once-daily with 2 nucleos(t)ide reverse transcriptase inhibitors (N[t]RTIs)...
April 7, 2017: Reviews on Recent Clinical Trials
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