Audrey Alesandra Stinghen Garcia Lonni, Vanessa Marquito Munhoz, Gisely Cristiny Lopes, Renata Longhini, Fernanda Belincanta Borghi-Pangoni, Rafaela Said Dos Santos, Mariana Volpato Junqueira, Maria Raquel Marçal Natali, Eneri Leite-Mello, Francine Baesso Guimaraes, Mauro Luciano Baesso, Ieda Spacino Scarminio, Marcos Luciano Bruschi, João Carlos Palazzo de Mello
Considering the antioxidant activity of the Trichilia catigua extract (TCE), the aim of the current study was to develop and characterize W/O/W multiple emulsions containing different vegetable oils as a platform to deliver a TCE. The extract displayed antioxidant activity (IC50 ) of 4.59 µg/mL and total phenol content (TPC) of 50.84%. Formulations were prepared by the phase-inversion emulsification method and analyzed for morphological appearance, pH, conductivity, droplet size and distribution, content of active, rheological properties, in vitro release, skin permeation, and stability...
December 2016: Pharmaceutical Development and Technology