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Nadini Oliveira Martins, Isabella Modelli de Brito, Sandra Syomara O Araújo, Giuseppina Negri, Elisaldo de Araújo Carlini, Fúlvio Rieli Mendes
BACKGROUND: Trichilia catigua A. Juss. (Meliaceae) is a species known as catuaba and used in folk medicine for the treatment of fatigue, stress, impotence and memory deficit. The main phytochemical compounds identified in the barks of T. catigua are flavalignans, flavan-3-ols and flavonoids which are associated with its antioxidant activity. Pre-clinical studies with T. catigua extracts have identified many pharmacological properties, such as anti-inflammatory, antidepressant, antinociceptive, pro-memory and neuroprotective against ischemia and oxidative stress...
June 5, 2018: BMC Complementary and Alternative Medicine
Leandro José Ramos, Gabriela Vieira de Souza Castro, Janis Lunier de Souza, Jader de Oliveira, João Aristeu da Rosa, Luis Marcelo Aranha Camargo, Renildo Moura da Cunha, Dionatas Ulises de Oliveira Meneguetti
INTRODUCTION: This communication reports the occurrence of Rhodnius neglectus in the State of Acre, Brazil. METHODS: An adult male R. neglectus specimen was collected from the Catuaba Experimental Reserve, which is located in the municipality of Senador Guiomard. RESULTS: This increases the number of triatomine species reported from the State of Acre to eight and is also the first report of R. neglectus from the Brazilian Western Amazon Region...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
João Bernardo, Federico Ferreres, Ángel Gil-Izquierdo, Romeu António Videira, Patrícia Valentão, Francisco Veiga, Paula B Andrade
ETHNOPHARMACOLOGICAL RELEVANCE: The bark of Trichilia catigua A. Juss. (Meliaceae), popularly known as "big catuaba", is traditionally used in Brazilian folk medicine for its neuroactive potential as memory stimulant, and antinociceptive and antidepressant effects. AIM OF THE STUDY: To study the aqueous extract of T. catigua bark as dual inhibitor of monoamine oxidase A (MAO-A) and acetylcholinesterase (AChE). To explore its antioxidant potential through interaction with xanthine/xanthine oxidase (X/XO) pathway, and to attempt a relationship between its phenolic profile and effects displayed...
September 29, 2017: Journal of Ethnopharmacology
Rodrigo Mello Gomes, Luis Fernando de Paulo, Cynthia Priscilla do Nascimento Bonato Panizzon, Camila Quaglio Neves, Bruna Colombo Cordeiro, Jacqueline Nelisis Zanoni, Flávio Andrade Francisco, Silvano Piovan, Paulo Cezar de Freitas Mathias, Renata Longhini, João Carlos Palazzo de Mello, Júlio Cezar de Oliveira, Gustavo Rodrigues Pedrino, Angela Adamski da Silva Reis, Alessandra Lourenço Cecchini, Maria Raquel Marçal Natali
BACKGROUND/AIMS: Trichilia catigua A. Juss., known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, our group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabetic rats. METHODS: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic group, NC: non-diabetic + EAF group and DC: type 1 diabetic + EAF group)...
2017: Cellular Physiology and Biochemistry
Ana Luiza Sereia, Renata Longhini, Gisely Cristiny Lopes, João Carlos Palazzo de Mello
INTRODUCTION: The tree Trichilia catigua, popularly known as "catuaba", shows several biological activities and has emerged as a potential source of new drugs. Considering that more than 10 species are known under the same popular name, regulatory agencies require more rigorous quality control of this medicinal plant. OBJECTIVE: To develop and validate a methodology using capillary electrophoresis (CE) with ultraviolet (UV) detection for analysing polyphenols in the ethyl-acetate fraction (EAF) of Trichilia catigua...
May 2017: Phytochemical Analysis: PCA
Audrey Alesandra Stinghen Garcia Lonni, Vanessa Marquito Munhoz, Gisely Cristiny Lopes, Renata Longhini, Fernanda Belincanta Borghi-Pangoni, Rafaela Said Dos Santos, Mariana Volpato Junqueira, Maria Raquel Marçal Natali, Eneri Leite-Mello, Francine Baesso Guimaraes, Mauro Luciano Baesso, Ieda Spacino Scarminio, Marcos Luciano Bruschi, João Carlos Palazzo de Mello
Considering the antioxidant activity of the Trichilia catigua extract (TCE), the aim of the current study was to develop and characterize W/O/W multiple emulsions containing different vegetable oils as a platform to deliver a TCE. The extract displayed antioxidant activity (IC50) of 4.59 µg/mL and total phenol content (TPC) of 50.84%. Formulations were prepared by the phase-inversion emulsification method and analyzed for morphological appearance, pH, conductivity, droplet size and distribution, content of active, rheological properties, in vitro release, skin permeation, and stability...
December 2016: Pharmaceutical Development and Technology
Alice Hartmann Dos Santos, Aline Camargo Ramos, Kennia Moura Silveira, Ana Carolina Inhasz Kiss, Renata Longhini, Andréa Diniz, João Carlos Palazzo de Mello, Daniela Cristina Ceccatto Gerardin
ETHNOPHARMACOLOGICAL RELEVANCE: Trichilia catigua is broadly used in folk medicine due to its mental and physical tonic activities and stimulant effects. In animal models, its antidepressant-like effects have been associated with the dopaminergic (DA) system modulation, which has an important role on maternal behavior and male offspring reproductive development. AIM OF THE STUDY: Since little is known about the adverse effects of the exposure to T. catigua crude extract (CAT) in rats, specially regarding maternal homeostasis and offspring development, the aim of the present study was to evaluate whether CAT exposure may influence maternal toxicity parameters and behavior or disrupt male offspring physical and reproductive development...
May 26, 2015: Journal of Ethnopharmacology
Jean Paul Kamdem, Emily Pansera Waczuk, Ige Joseph Kade, Caroline Wagner, Aline Augusti Boligon, Margareth Linde Athayde, Diogo Onofre Souza, João Batista Teixeira Rocha
Oxidative stress is implicated in brain damage associated with ischemia-reperfusion. Natural antioxidants found in some plants used in folk medicine have been indicated as potential neuroprotective agents. Here we investigated whether Trichilia catigua, a traditional Brazilian herbal medicine alleged to exhibit a variety of neuropharmacological properties (antidepressant, anti-neurasthenic, anti-inflammatory etc.), could have neuroprotective properties in rat hippocampal slices subjected to 2 h oxygen and glucose deprivation (OGD) followed by 1 h reperfusion...
December 2012: Neurochemical Research
Emerson F Queiroz, Boris Zanolari, Andrew Marston, David Guilet, Leila Burgener, Marçal de Queiroz Paulo, Kurt Hostettmann
Two new tropane alkaloid N-oxides substituted by a methylpyrrole moiety were isolated from the bark of Erythroxylum vacciniifolium Mart. (Erythroxylaceae), a Brazilian indigenous plant, locally known as catuaba and used in traditional medicine as an aphrodisiac. The alkaloid structures were determined by a combination of high resolution mass spectrometry and multi-dimensional NMR spectroscopy.
October 2009: Natural Product Communications
A P Batistini, M P C Telles, B W Bertoni, J S Coppede, F V Môro, S C França, A M S Pereira
Catuaba (Anemopaegma arvense), a Bignoniaceae species endemic to Cerrado regions, shows anticancer properties and is widely used as a stimulant in traditional medicine. We evaluated the genetic diversity of seven populations found in the State of São Paulo, using random amplified polymorphic DNA markers. After optimization of the amplification reaction, 10 selected primers produced 70 reproducible bands, with 72.8% polymorphism. The greatest genetic diversity was observed within populations (71.72%). Variation estimates, theta(B) (0...
2009: Genetics and Molecular Research: GMR
Deyse Valverde G De Andrade, Diêgo Madureira de Oliveria, George Barreto, Laura-Aon Bertolino, Ezequiel Saraceno, Francisco Capani, Lisandro Diego Giraldez
Parkinson's disease (PD) is one of the most important neurodegenerative worldwide disorders. It is characterized by a selective and progressive degeneration of dopaminergic neurons, causing a series of symptoms which might ultimately induce programmed cell death. The potential cytoprotective effects of one of the commercial extracts of Anemopaegma mirandum (Catuaba), a Brazilian tree, on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells was demonstrated. The cell viability, analysis of cellular morphology, nuclei morphology and ultra structural research were done by MTT-tetrazole (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, phase contrast microscopy, stained with Hoechst 33258 and electron microscopy transmission, respectively...
March 10, 2008: Brain Research
Cristina Daolio, Flávio L Beltrame, Antonio G Ferreira, Quezia B Cass, Diógenes Aparício Garcia Cortez, Márcia M C Ferreira
For over a century, Catuaba has been used in Brazilian folk medicine as an aphrodisiac even though the identity of the plant material employed is often uncertain. The species recommended by the Brazilian Pharmacopeia is Anemopaegma arvense (Bignoniaceae), but many other plants, regionally known as Catuaba, are commercialised. Frequently, the quality control of such a complex system is based on chemical markers that do not supply a general idea of the system. With the advent of the metabolomics approach, a global analysis of samples becomes possible...
May 2008: Phytochemical Analysis: PCA
Nurhayat Tabanca, Rahul S Pawar, Daneel Ferreira, Jannie P Marais, Shabana I Khan, Vaishali Joshi, David E Wedge, Ikhlas A Khan
One of the species of commercially available catuaba was identified as Anemopaegma arvense by comparison of its micromorphological characteristics and TLC profile with six species of authenticated plants that are commonly referred to as catuaba. The bioactivity-guided fractionation of the ethyl acetate extract of the stem bark of this catuaba sample resulted in the isolation of one new (1, catuabin A) and three known flavan-3-ol type phenylpropanoids, cinchonain Ia (2), cinchonain IIa (3), and kandelin A1 (4) with antioxidant activities...
August 2007: Planta Medica
Flávio Luís Beltrame, Edson Rodrigues Filho, Fabio A Proença Barros, Diógenes Aparíciogarcia Cortez, Quezia Bezerra Cass
The hydroalcoholic extract, prepared from authentic chopped barks of Trichilia catigua, was evaluated by high-performance liquid chromatography using a diode array detector (200-400 mn). The crude extract was purified by rotation locular counter-current chromatography and the chloroform fraction obtained was clean-up by solid-phase extraction. With the aim of getting preliminary structure information on-line, the methanol fraction thus obtained was analyzed by gradient elution using the diode array detector coupled to a mass spectrometer...
June 30, 2006: Journal of Chromatography. A
André Rolim, Tânia Oishi, Carolina P M Maciel, Vivian Zague, Claudinéia A S O Pinto, Telma M Kaneko, Vladi O Consiglieri, Maria Valéria R Velasco
A new derivative spectrophotometric (DS) method was proposed and validated for quantification of total flavonoids from in O/W emulsion with polyacrylamide (and) C13-14 isoparaffin (and) laureth-7 containing Catuaba (Trichilia catigua Adr. Juss) (and) Marapuama (Ptychopetalum olacoides Bentham) extract. DS method was optimized to perform the assay in most favorable conditions. Linearity, specificity and selectivity, recovery (Rc, %), precision (R.S.D., %), accuracy (E, %), detection (LOD, microg ml(-1)) and quantification limits (LOQ, microg ml(-1)) were established for method validation...
February 3, 2006: International Journal of Pharmaceutics
Boris Zanolari, David Guilet, Andrew Marston, Emerson F Queiroz, Marçal de Queiroz Paulo, Kurt Hostettmann
Nine new tropane alkaloids substituted by a methylpyrrole moiety were isolated from the bark of Erythroxylum vacciniifolium, a Brazilian endemic plant used in traditional medicine and locally known as catuaba. All compounds were elucidated as tropanediol or -triol alkaloids esterified by at least one 1-methyl-1H-pyrrole-2-carboxylic acid. One of the isolated compounds was identified as a tropane alkaloid N-oxide. Their structures were determined by high-resolution mass spectrometry and multidimensional NMR spectroscopy...
August 2005: Journal of Natural Products
Maria M Campos, Elizabeth S Fernandes, Juliano Ferreira, Adair R S Santos, João B Calixto
RATIONALE: Currently available therapy for depression treatment is often associated with several undesirable side effects, and it is effective only in a certain portion of the population. Therefore, the identification of alternative therapeutic tools for the treatment of depression is still needed. OBJECTIVE: The present study analyzed the possible antidepressant-like effects of the Brazilian medicinal plant, Trichilia catigua, in rodents. Attempts were also made to investigate some of the possible mechanisms implicated in its actions...
October 2005: Psychopharmacology
Celso H Oliveira, Maria Elizabete A Moraes, Manoel O Moraes, Fernando A F Bezerra, Eduardo Abib, Gilberto De Nucci
In Brazil, a herbal medicinal extract named Catuama containing a mixture of Paullinia cupana (guarana; Sapindaceae), Trichilia catigua (catuaba; Meliaceae), Ptychopetalum olacoides (muirapuama; Olacaceae) and Zingiber officinale (ginger; Zingiberaceae) is used as a body stimulant, energetic, tonic and aphrodisiac. The present study investigated the chronic administration of 25 mL Catuama twice a day during 28 days for any toxic effect on healthy human volunteers of both sexes. No severe adverse reactions or haematological and biochemical changes were reported...
January 2005: Phytotherapy Research: PTR
Nádia R Barbosa, Lygia Fischmann, Leda L Talib, Wagner F Gattaz
In the inflammation process, phospholipase A2 (PLA2) catalyses the cleavage of the sn-2 ester-linked fatty acids from phospholipids, being the enzyme responsible for arachidonic acid (AA) release by cells for the biosynthesis of the prostaglandins and thromboxanes via the cyclooxygenase system, and the leukotrienes and eicosatetraenoids via the lipoxygenase pathway. AA mobilization by PLA2 and subsequent prostaglandins synthesis is considered to be a pivotal event in inflammation. Therefore, drugs that inhibit PLA2, thus blocking the COX and LOX pathways in the AA cascade, may be effective in the treatment of inflammatory processes...
November 2004: Phytotherapy Research: PTR
Christa Kletter, Sabine Glasl, Armin Presser, Ingrid Werner, Gottfried Reznicek, Samdan Narantuya, Selim Cellek, Ernst Haslinger, Johann Jurenitsch
Fourteen commercial samples of the popular Brazilian aphrodisiac Catuaba specified as bark drugs of Anemopaegma, Erythroxylum and Trichilia species were examined for identity and purity. Only a minority of the examined Catuaba samples contained the crude drugs claimed on the labels. More than half of the products were adulterated with different crude drugs. The majority of the samples contained a bark originating from Trichilia catigua. The TLC fingerprints confirmed the heterogeneity, in 50% of the samples tropane alkaloids of various concentrations were detected...
October 2004: Planta Medica
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