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Fabiane Cristina Petry, Adriana Zerlotti Mercadante
Interest about composition of carotenoid esters of fruits is growing since esterification may affect their bioavailability. Thus, the aim was to provide detailed identification of carotenoid esters in Citrus and mango. Orange cv. Valencia and cv. Pera presented 9 free carotenoids, 38 mono- and 60 diesters. Violaxanthin and luteoxanthin derivatives were the major ones, followed by antheraxanthin, lutein, zeaxanthin, β-cryptoxanthin and zeinoxanthin esters; many of them reported for the first time in orange pulp...
October 7, 2016: Journal of Agricultural and Food Chemistry
Wolfgang Stuetz, Daniela Weber, Martijn E T Dollé, Eugène Jansen, Beatrix Grubeck-Loebenstein, Simone Fiegl, Olivier Toussaint, Juergen Bernhardt, Efstathios S Gonos, Claudio Franceschi, Ewa Sikora, María Moreno-Villanueva, Nicolle Breusing, Tilman Grune, Alexander Bürkle
Blood micronutrient status may change with age. We analyzed plasma carotenoids, α-/γ-tocopherol, and retinol and their associations with age, demographic characteristics, and dietary habits (assessed by a short food frequency questionnaire) in a cross-sectional study of 2118 women and men (age-stratified from 35 to 74 years) of the general population from six European countries. Higher age was associated with lower lycopene and α-/β-carotene and higher β-cryptoxanthin, lutein, zeaxanthin, α-/γ-tocopherol, and retinol levels...
September 30, 2016: Nutrients
Dominika Głąbska, Dominika Guzek, Paulina Zakrzewska, Dariusz Włodarek, Gustaw Lech
BACKGROUND: The main symptom of ulcerative colitis is diarrhoea, which is often accompanied by painful tenesmus and faecal blood and mucus. It sometimes co-occurs with abdominal pain, fever, feeling of fatigue, loss of appetite and weight loss. Some dietary factors have been indicated as important in the treatment of ulcerative colitis. The aim of the study was to analyse the association between retinoid intake (total vitamin A, retinol, β-carotene, α-carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin) and ulcerative colitis symptoms (abdominal pain, faecal blood, faecal mucus, faecal pus) in individuals with ulcerative colitis in remission...
September 30, 2016: Nutrients
Lydi-Anne Vézina-Im, Gaston Godin, Charles Couillard, Julie Perron, Simone Lemieux, Julie Robitaille
BACKGROUND: Short instruments measuring frequency of specific foods, such as fruit and vegetable (FV), are increasingly used in interventions. The objective of the study was to verify the validity and test-retest reliability of such an instrument among pregnant women. METHODS: Pregnant women from the region of Quebec City, Quebec, Canada, were recruited through e-mails sent to female students and employees of the local university from October 2014 to April 2015...
2016: BMC Public Health
Ruchira Mitra, Surabhi Chaudhuri, Debjani Dutta
In the present investigation, growth kinetics of Kocuria marina DAGII during batch production of β-Cryptoxanthin (β-CRX) was studied by considering the effect of glucose and maltose as a single and binary substrate. The importance of mixed substrate over single substrate has been emphasised in the present study. Different mathematical models namely, the Logistic model for cell growth, the Logistic mass balance equation for substrate consumption and the Luedeking-Piret model for β-CRX production were successfully implemented...
September 15, 2016: Bioprocess and Biosystems Engineering
Anita R Iskandar, Benchun Miao, Xinli Li, Kang-Quan Hu, Chun Liu, Xiang-Dong Wang
Despite the consistent association between a higher intake of the provitamin A carotenoid β-cryptoxanthin (BCX) and a lower risk of lung cancer among smokers, potential mechanisms supporting BCX as a chemopreventive agent are needed. We first examined the effects of BCX on 4-[methyl nitrosamino]-1-[3-pyridyl]-1-butanone (NNK)-induced lung tumorigenesis in A/J mice. BCX supplementation was given daily to the mice starting two-weeks prior to the injection of NNK and continued 16 weeks post NNK injection. BCX supplementation resulted in a dose-dependent increase of BCX concentration in both serum and lungs of the mice without a significant alteration of vitamin A (retinol and retinyl palmitate) concentration...
September 13, 2016: Cancer Prevention Research
Keiko Unno, Shigenori Noda, Yohei Kawasaki, Kazuaki Iguchi, Hiroshi Yamada
Beta-cryptoxanthin [β-CRX, (3R)-β, β-caroten-3-ol] is a provitamin A and a potent antioxidant that is abundant in Satsuma mandarin orange (Citrus unshiu MARC.), which is the most popular fruit in Japan. The anti-stress effect of β-CRX on humans was evaluated in fifth-year university students during both routine daily life at the university and at pharmacy practice. The study design was a double-blind group comparison and participants (n=20; female 12, male 8) were randomly assigned to β-CRX-rich orange juice or placebo (β-CRX was removed from orange juice) groups...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Sabine Baumgartner, Rouyanne T Ras, Elke A Trautwein, Ronald P Mensink, Jogchum Plat
PURPOSE: Plant sterols and stanols interfere with intestinal cholesterol absorption, and it has been questioned whether absorption and plasma concentrations of fat-soluble vitamins and carotenoids are also affected. We conducted a meta-analysis to assess the effects of plant sterol and stanol consumption on plasma fat-soluble vitamin and carotenoid concentrations. METHODS: Forty-one randomized controlled trials involving 3306 subjects were included. Weighted absolute and relative changes of non-standardized and total cholesterol (TC)-standardized values (expressed as summary estimates and 95 % CIs) were calculated for three fat-soluble vitamins (α- and γ-tocopherol, retinol and vitamin D) and six carotenoids (β-carotene, α-carotene, lycopene, lutein, zeaxanthin and β-cryptoxanthin) using a random effects model...
September 3, 2016: European Journal of Nutrition
Charles Couillard, Simone Lemieux, Marie-Claude Vohl, Patrick Couture, Benoît Lamarche
High fruit and vegetable (FAV) intake is associated with a lower prevalence of chronic diseases. Identifying the ideal number of FAV servings needed to reduce chronic disease risk is, however, difficult because of biases inherent to common self-report dietary assessment tools. The aim of our study was to examine the associations between daily FAV intake and plasma carotenoid concentrations in men and women enrolled in a series of fully controlled dietary interventions. We compiled and analysed data from a group of 155 men and 109 women who participated in six fully controlled dietary interventions and compared post-intervention fasting plasma carotenoid (α-carotene, β-carotene, β-cryptoxanthin, lutein, lycopene, zeaxanthin) concentrations with regard to the daily FAV servings consumed by the participants...
October 2016: British Journal of Nutrition
Filiz Uçan, Erdal Ağçam, Asiye Akyildiz
In this study, bioactive compounds (phenolic and carotenoid) and some quality parameters (color, browning index and hydroxymethylfurfural (HMF)) of natural cloudy lemon juice, pasteurized (90 °C/15 s) and storage stability of concentrated lemon juice (-25 °C/180 days) were carried out. Fifteen phenolic compounds were determined in the lemon juice and the most abounded phenolic compounds were hesperidin, eriocitrin, chlorogenic acid and neoeriocitrin. In generally, phenolic compound concentrations of lemon juice samples increased after the pasteurization treatment...
March 2016: Journal of Food Science and Technology
Yu Fen Zheng, Jee Sun Min, Doyun Kim, Jung Bae Park, Sung-Wook Choi, Eun Seong Lee, Kun Na, Soo Kyung Bae
Despite the widespread use of the five major xanthophylls astaxanthin, β-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin as dietary supplements, there have been no studies regarding their inhibitory effects on hepatic UDP-glucuronosyltransferases (UGTs). Here, we evaluated the inhibitory potential of these xanthophylls on the seven major human hepatic UGTs (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7 and UGT2B15) in vitro by LC-MS/MS using specific marker reactions in human liver microsomes (except UGT2B15) or recombinant supersomes (UGT2B15)...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
M Luisa Bonet, Jose A Canas, Joan Ribot, Andreu Palou
Cell, animal and human studies dealing with carotenoids and carotenoid derivatives as nutritional regulators of adipose tissue biology with implications for the etiology and management of obesity and obesity-related metabolic diseases are reviewed. Most studied carotenoids in this context are β-carotene, cryptoxanthin, astaxanthin and fucoxanthin, together with β-carotene-derived retinoids and some other apocarotenoids. Studies indicate an impact of these compounds on essential aspects of adipose tissue biology including the control of adipocyte differentiation (adipogenesis), adipocyte metabolism, oxidative stress and the production of adipose tissue-derived regulatory signals and inflammatory mediators...
2016: Sub-cellular Biochemistry
Minoru Sugiura, Mieko Nakamura, Kazunori Ogawa, Yoshinori Ikoma, Masamichi Yano
Recent epidemiological studies show that antioxidant vitamins and carotenoids might be beneficial to the maintenance of bone health. Recently, we found that serum carotenoids were inversely associated with the risk of developing osteoporosis in post-menopausal Japanese female subjects. However, little is known about the vitamin alone and/or the combination of the vitamin and carotenoid with the risk of osteoporosis. The objective of this study was to investigate longitudinally whether antioxidant vitamins and their combination with carotenoids are associated with the risk of developing of osteoporosis...
2016: Journal of Nutritional Science and Vitaminology
Karma Pearce, Kelton Tremellen
The early loss of ovarian reserve and subsequent menopause has a major impact on fertility potential and increases the risk of cardiovascular disease, osteoporosis, cognitive decline and mortality later in life. While many studies have reported that lifestyle factors such as diet can influence the age of onset of natural menopause, their results are often contradictory. Therefore, the aim of this study was to examine the influence of diet on the onset of natural menopause using a self-reported food frequency questionnaire in a cohort of 1146 pre-menopausal women followed up for an average of 12...
September 2016: Human Fertility: Journal of the British Fertility Society
Maria Irakli, Paschalina Chatzopoulou, Kalliopi Kadoglidou, Nektaria Tsivelika
A simple and reliable high-performance liquid chromatography method was developed and validated for the simultaneous determination of lipophilic antioxidants in tomato fruits using C30 column operated at 15°C and a gradient mobile phase based on acetonitrile/methanol/dichloromethane in a total run time of 30 min. Diode array and fluorescence detectors were used respectively for the detection of carotenoids (lutein, zeaxanthin, cryptoxanthin, lycopene, and β-carotene) and vitamin E analogs (α-, β-, γ-, and δ-tocopherols, and tocotrienols)...
September 2016: Journal of Separation Science
Blanca Escudero-López, Isabel Cerrillo, Ángel Gil-Izquierdo, Dámaso Hornero-Méndez, Griselda Herrero-Martín, Genoveva Berná, Sonia Medina, Federico Ferreres, Franz Martín, María-Soledad Fernández-Pachón
Previously, we reported that alcoholic fermentation enhanced flavanones and carotenoids content of orange juice. The aim of this work was to evaluate the influence of pasteurization on the qualitative and quantitative profile of bioactive compounds and the antioxidant capacity of fermented orange juice. Ascorbic acid (203 mg/L), total flavanones (647 mg/L), total carotenoids (7.07 mg/L) and provitamin A (90.06 RAEs/L) values of pasteurized orange beverage were lower than those of fermented juice. Total phenolic remained unchanged (585 mg/L) and was similar to that of original juice...
November 2016: International Journal of Food Sciences and Nutrition
Leila Abar, Ana Rita Vieira, Dagfinn Aune, Christophe Stevens, Snieguole Vingeliene, Deborah A Navarro Rosenblatt, Doris Chan, Darren C Greenwood, Teresa Norat
Carotenoids and retinol are considered biomarkers of fruits and vegetables intake, and are of much interest because of their anti-inflammatory and antioxidant properties; however, there is inconsistent evidence regarding their protective effects against lung cancer. We conducted a meta-analysis of prospective studies of blood concentrations of carotenoids and retinol, and lung cancer risk. We identified relevant prospective studies published up to December 2014 by searching the PubMed and several other databases...
August 2016: Cancer Medicine
Masaaki Hikita, Kento Motojima, Sumito Kamata, Testuro Yoshida, Sawako Tanaka-Nakadate, Kazuhiko Nakadate
β-cryptoxanthin is a common carotenoid pigment found in fruit, especially in Satsuma mandarins and in persimmons. After ingestion, β-cryptoxanthin is distributed to and accumulates in organs, such as the liver, lung, and kidney. Recent studies have reported that because of its antioxidant defense, β-cryptoxanthin performs several important functions in the preservation of human health and in the prevention of several diseases, including cancer and osteoporosis. The present study aims to determine whether β-cryptoxanthin has a protective effect on renal glomeruli during acute nephritis...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Jiamin Chen, Wuxia Jiang, Liming Shao, Dandan Zhong, Yihua Wu, Jianting Cai
We conducted a meta-analysis to systematically evaluate the association between antioxidants intake and pancreatic cancer risk. Relevant articles were retrieved from PUBMED and EMBASE databases and standard meta-analysis methods were applied. Finally a total of 18 studies were included. Comparing the highest with lowest categories, higher dietary intakes of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin were significantly associated with reduced pancreatic cancer risk (for selenium, pooled OR = 0...
November 2016: International Journal of Food Sciences and Nutrition
Yinhua Ni, Fen Zhuge, Mayumi Nagashimada, Tsuguhito Ota
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. It is characterized by a wide spectrum of hepatic changes, which may progress to non-alcoholic steatohepatitis (NASH) and cirrhosis. NAFLD is considered a hepatic manifestation of metabolic syndrome; however, mechanisms underlying the onset and progression of NAFLD are still unclear. Resident and recruited macrophages are key players in the homeostatic function of the liver and in the progression of NAFLD to NASH. Progress has been made in understanding the molecular mechanisms underlying the polarized activation of macrophages...
2016: Nutrients
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