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https://www.readbyqxmd.com/read/28102015/circulating-antioxidant-levels-and-risk-of-prostate-cancer-by-tmprss2-erg
#1
Rebecca E Graff, Gregory Judson, Thomas U Ahearn, Michelangelo Fiorentino, Massimo Loda, Edward L Giovannucci, Lorelei A Mucci, Andreas Pettersson
BACKGROUND: Few studies have considered etiological differences across molecular subtypes of prostate cancer, despite potential to improve opportunities for precision prevention of a disease for which modifiable risk factors have remained elusive. Factors that lead to DNA double-strand breaks, such as oxidative stress, may promote the formation of the TMPRSS2:ERG gene fusion in prostate cancer. We tested the hypothesis that increasing levels of pre-diagnostic circulating antioxidants, which may reduce oxidative stress, are associated with lower risk of developing TMPRSS2:ERG positive prostate cancer...
January 19, 2017: Prostate
https://www.readbyqxmd.com/read/28079511/circulating-carotenoids-and-subsequent-risk-of-rheumatoid-arthritis-in-women
#2
Yang Hu, Jing Cui, Jeffrey A Sparks, Susan Malspeis, Karen H Costenbader, Elizabeth W Karlson, Bing Lu
OBJECTIVES: The aim of the present study was to examine the associations between circulating carotenoids and future risk of rheumatoid arthritis (RA). METHODS: We conducted a nested case-control study consisting of 227 incident RA cases and 671 matched controls with prospectively measured plasma carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene and lutein/zeaxanthin) levels in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHS II). Each incident RA case was matched with 3 healthy controls...
January 4, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28041601/higher-intake-of-cryptoxanthin-is-related-to-low-body-mass-index-and-body-fat-in-japanese-middle-aged-women
#3
Asuka Hirose, Masakazu Terauchi, Miho Hirano, Mihoko Akiyoshi, Yoko Owa, Kiyoko Kato, Toshiro Kubota
OBJECTIVES: The prevalence of cardiovascular diseases increases with age, especially in postmenopausal women. In this study, we investigated the dietary patterns associated with body mass and body fat in Japanese middle-aged women. STUDY DESIGN: Cross-sectional. MAIN OUTCOME MEASURES: This study used baseline data collected in a previous study in 88 women aged 40-60 years. Participants were assessed for age, menopausal status, lifestyle factors, body composition, and dietary habits using a brief-type self-administered diet history questionnaire, which provides information on the amounts of nearly 100 nutritional factors consumed during the previous month...
February 2017: Maturitas
https://www.readbyqxmd.com/read/28018400/identification-and-expression-analysis-of-candidate-genes-involved-in-carotenoid-biosynthesis-in-chickpea-seeds
#4
Mohammad K Rezaei, Amit Deokar, Bunyamin Tar'an
Plant carotenoids have a key role in preventing various diseases in human because of their antioxidant and provitamin A properties. Chickpea is a good source of carotenoid among legumes and its diverse germplasm and genome accessibility makes it a good model for carotenogenesis studies. The structure, location, and copy numbers of genes involved in carotenoid biosynthesis were retrieved from the chickpea genome. The majority of the single nucleotide polymorphism (SNPs) within these genes across five diverse chickpea cultivars was synonymous mutation...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28017254/role-of-vitamin-a-metabolism-in-iih-results-from-the-idiopathic-intracranial-hypertension-treatment-trial
#5
J Libien, M J Kupersmith, W Blaner, M P McDermott, S Gao, Y Liu, J Corbett, M Wall
INTRODUCTION: Vitamin A and its metabolites (called retinoids) have been thought to play a role in the development of idiopathic intracranial hypertension (IIH). The IIH Treatment Trial (IIHTT) showed the efficacy of acetazolamide (ACZ) in improving visual field function, papilledema grade, quality of life and cerebrospinal fluid (CSF) pressure. We postulated that IIH patients would demonstrate elevated measures of vitamin A metabolites in the serum and CSF. METHODS: Comprehensive measures of serum vitamin A and its metabolites were obtained from 96 IIHTT subjects, randomly assigned to treatment with ACZ or placebo, and 25 controls with similar gender, age and body mass index (BMI)...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28011986/carotenoid-intake-and-risk-of-non-hodgkin-lymphoma-a-systematic-review-and-dose-response-meta-analysis-of-observational-studies
#6
REVIEW
Feifei Chen, Jiyi Hu, Ping Liu, Jing Li, Zheng Wei, Peng Liu
Carotenoids may play a protective role in the development of non-Hodgkin lymphoma (NHL), but findings from epidemiological studies on the associations between carotenoid intake and NHL risk are inconsistent. We therefore performed a meta-analysis to systemically evaluate the associations. Eligible studies were identified by a search of PubMed, Web of Science, Embase, and article reference lists. We pooled risk estimates from individual studies using a random-effect model to quantify the associations between intakes of specific carotenoids and NHL risk...
December 24, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/28005968/common-snp-rs6564851-in-the-bco1-gene-affects-the-circulating-levels-of-%C3%AE-carotene-and-the-daily-intake-of-carotenoids-in-healthy-japanese-women
#7
Suemi Yabuta, Masanori Urata, Roseline Yap Wai Kun, Motofumi Masaki, Yoshihiro Shidoji
The circulating levels of β-carotene are modulated not only by sex, but also by autosomal gene variations and fruit intake. The aim of this study was to investigate the interactions between β-carotene metabolism-related gene single nucleotide polymorphisms (SNPs; genetic factors) and nutrient intake (environmental factors) relating to their effects on circulating β-carotene. The serum concentrations of β-carotene and the habitual food intake of 92 healthy Japanese adults were examined. All subjects were genotyped for three common SNPs: rs6564851 in the β-carotene 15,15'-oxygenase 1 (BCO1) gene, rs2278986 in the scavenger receptor class B member 1 (SCARB1) gene and rs362090 in the intestine-specific homeobox (ISX) gene...
2016: PloS One
https://www.readbyqxmd.com/read/27913933/fatigue-reduction-diet-in-breast-cancer-survivors-a-pilot-randomized-clinical-trial
#8
Suzanna Maria Zick, Justin Colacino, Maria Cornellier, Tohfa Khabir, Katie Surnow, Zora Djuric
PURPOSE: Fatigue is a prevalent and burdensome effect of breast cancer. Fatigue has been linked to chronic inflammation, and diets high in antioxidant nutrients have been associated with lesser prevalence and severity of fatigue. Studies are needed, however, to test if antioxidant-rich diets could improve fatigue. METHODS: Pilot, randomized, trial conducted between January 2014 and April 2015, to investigate if a 3-month diet rich in fruit, vegetables, whole grains, and omega-3 fatty acid-rich foods, named the fatigue reduction diet (FRD), improved fatigue and sleep compared to an attention control, named the general health curriculum (GHC)...
January 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27903840/evaluation-of-antioxidant-intakes-in-relation-to-inflammatory-markers-expression-within-the-normal-breast-tissue-of-breast-cancer-patients
#9
Danielle Larouche, Mirette Hanna, Sue-Ling Chang, Simon Jacob, Bernard Têtu, Caroline Diorio
Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tissue. We aimed to evaluate correlations between antioxidant (vitamin A/retinol, vitamin C, vitamin E, β-carotene, α-carotene, lycopene, lutein/zeaxanthin, β-cryptoxanthin, selenium, and zinc) intakes and protein expression levels of interleukin (IL)-6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase-2, leptin, serum amyloid A1, signal transducer and activator of transcription 3, IL-8, IL-10, lactoferrin, and transforming growth factor-β measured in the normal breast tissue of 160 women diagnosed with breast cancer...
November 30, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27899047/phytochemicals-and-antioxidant-capacity-in-four-italian-traditional-maize-zea-mays-l-varieties
#10
Antonella Capocchi, Stefania Bottega, Carmelina Spanò, Debora Fontanini
Flours of four pigmented (from orange to red and dark red) local Italian corns, studied for their soluble, soluble conjugate, and insoluble-bound phenols and flavonoids, showed a prevalence of the insoluble-bound fraction (70-80%). Correlations were found between the flours antioxidant capacity, measured with CUPRAC, FRAP, and DPPH methods, and soluble phenols and flavonoids content. A correlation was also found between ascorbic acid content and flours antioxidant power. Anthocyanins were present in small amounts in the red/dark red seeds; however, acid-alcohol assays and spectral analyses of pericarp extracts indicated the presence of red-brick phlobaphenes in these varieties...
November 29, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27862386/no-detectable-carotenoid-concentrations-in-serum-of-llamas-and-alpacas
#11
J Raila, F J Schweigert, A Stanitznig, B Lambacher, S Franz, S Baldermann, T Wittek
Carotenoids are lipid-soluble pigments and important for a variety of physiological functions. They are major dietary vitamin A precursors and act as lipophilic antioxidants in a variety of tissues and are associated with important health benefits in humans and animals. All animals must acquire carotenoids from their diet, but to our knowledge, there are no studies investigating the intestinal carotenoid absorption and their blood concentrations in New World camelids. The present study aimed to assess the serum concentrations of selected carotenoids in llamas (n = 13) and alpacas (n = 27)...
November 9, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27862054/determination-of-target-fat-soluble-micronutrients-in-rainbow-trout-s-muscle-and-liver-tissues-by-liquid-chromatography-with-diode-array-tandem-mass-spectrometry-detection
#12
Virginia Pérez Fernández, Salvatore Ventura, Pierpaolo Tomai, Roberta Curini, Alessandra Gentili
This paper describes an analytical approach, based on LC-diode array detector-MS/MS (LC-DAD-MS/MS), for characterizing the fat-soluble micronutrient fraction in rainbow trout (Oncorhynchus mykiss). Two different procedures were applied to isolate the analytes from liver and muscle tissue: overnight cold saponification to hydrolyze bound forms and to simplify the analysis; matrix solid-phase dispersion to avoid artifacts and to maintain unaltered the naturally occurring forms. Analytes were separated on a C30 analytical column by using a nonaqueous reversed mobile phase compatible with the atmospheric pressure chemical ionization...
November 12, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27812831/carotenoids-phenolic-profile-mineral-content-and-antioxidant-properties-in-flesh-and-peel-of-prunus-persica-fruits-during-two-maturation-stages
#13
Samia Dabbou, Samira Maatallah, Antonella Castagna, Monia Guizani, Wala Sghaeir, Hichem Hajlaloui, Annamaria Ranieri
Carotenoids and phenolic profile, antioxidant activity as well as concentrations of selected macronutrients (K, N, Mg, Ca and Na) and micronutrients (Zn, Cu and Mn) in flesh and peel of peach fruit were recorded at two harvest dates. Predominant mineral was potassium, followed by calcium, magnesium and sodium. The concentration of most micronutrients was greater in the peel than in the flesh especially in early season. The concentration of most elements in flesh and peel decreased during fruit maturation. Total carotenoids content varied with respect to the cultivar...
November 3, 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27801820/a-comparison-of-nutritional-antioxidant-content-in-breast-milk-donor-milk-and-infant-formulas
#14
Corrine Hanson, Elizabeth Lyden, Jeremy Furtado, Matthew Van Ormer, Ann Anderson-Berry
Human milk is the optimal food for human infants, including infants born prematurely. In the event that a mother of a hospitalized infant cannot provide breast milk, donor milk is considered an acceptable alternative. It is known that the macronutrient composition of donor milk is different than human milk, with variable fat content and protein content. However, much less is known about the micronutrient content of donor milk, including nutritional antioxidants. Samples of breast milk from 12 mothers of infants hospitalized in the Newborn Intensive Care Unit until were collected and analyzed for concentrations of nutritional antioxidants, including α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein + zeaxanthin, retinol, and α-tocopherol...
October 28, 2016: Nutrients
https://www.readbyqxmd.com/read/27712060/composition-by-lc-ms-ms-of-new-carotenoid-esters-in-mango-and-citrus
#15
Fabiane C Petry, Adriana Z Mercadante
Interest in the composition of carotenoid esters of fruits is growing because esterification may affect their bioavailability. Thus, the aim was to provide a detailed identification of carotenoid esters in citrus and mango. Orange cv. 'Valencia' and cv. 'Pera' presented 9 free carotenoids, 38 monoesters, and 60 diesters. Violaxanthin and luteoxanthin derivatives were the major ones, followed by antheraxanthin, lutein, zeaxanthin, β-cryptoxanthin, and zeinoxanthin esters, many of them reported for the first time in orange pulp...
November 2, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27706032/plasma-carotenoids-tocopherols-and-retinol-in-the-age-stratified-35-74-years-general-population-a-cross-sectional-study-in-six-european-countries
#16
Wolfgang Stuetz, Daniela Weber, Martijn E T Dollé, Eugène Jansen, Beatrix Grubeck-Loebenstein, Simone Fiegl, Olivier Toussaint, Juergen Bernhardt, Efstathios S Gonos, Claudio Franceschi, Ewa Sikora, María Moreno-Villanueva, Nicolle Breusing, Tilman Grune, Alexander Bürkle
Blood micronutrient status may change with age. We analyzed plasma carotenoids, α-/γ-tocopherol, and retinol and their associations with age, demographic characteristics, and dietary habits (assessed by a short food frequency questionnaire) in a cross-sectional study of 2118 women and men (age-stratified from 35 to 74 years) of the general population from six European countries. Higher age was associated with lower lycopene and α-/β-carotene and higher β-cryptoxanthin, lutein, zeaxanthin, α-/γ-tocopherol, and retinol levels...
September 30, 2016: Nutrients
https://www.readbyqxmd.com/read/27706028/lycopene-lutein-and-zeaxanthin-may-reduce-faecal-blood-mucus-and-pus-but-not-abdominal-pain-in-individuals-with-ulcerative-colitis
#17
Dominika Głąbska, Dominika Guzek, Paulina Zakrzewska, Dariusz Włodarek, Gustaw Lech
BACKGROUND: The main symptom of ulcerative colitis is diarrhoea, which is often accompanied by painful tenesmus and faecal blood and mucus. It sometimes co-occurs with abdominal pain, fever, feeling of fatigue, loss of appetite and weight loss. Some dietary factors have been indicated as important in the treatment of ulcerative colitis. The aim of the study was to analyse the association between retinoid intake (total vitamin A, retinol, β-carotene, α-carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin) and ulcerative colitis symptoms (abdominal pain, faecal blood, faecal mucus, faecal pus) in individuals with ulcerative colitis in remission...
September 30, 2016: Nutrients
https://www.readbyqxmd.com/read/27633975/validity-and-reliability-of-a-brief-self-reported-questionnaire-assessing-fruit-and-vegetable-consumption-among-pregnant-women
#18
Lydi-Anne Vézina-Im, Gaston Godin, Charles Couillard, Julie Perron, Simone Lemieux, Julie Robitaille
BACKGROUND: Short instruments measuring frequency of specific foods, such as fruit and vegetable (FV), are increasingly used in interventions. The objective of the study was to verify the validity and test-retest reliability of such an instrument among pregnant women. METHODS: Pregnant women from the region of Quebec City, Quebec, Canada, were recruited through e-mails sent to female students and employees of the local university from October 2014 to April 2015...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27628580/modelling-the-growth-kinetics-of-kocuria-marina-dagii-as-a-function-of-single-and-binary-substrate-during-batch-production-of-%C3%AE-cryptoxanthin
#19
Ruchira Mitra, Surabhi Chaudhuri, Debjani Dutta
In the present investigation, growth kinetics of Kocuria marina DAGII during batch production of β-Cryptoxanthin (β-CRX) was studied by considering the effect of glucose and maltose as a single and binary substrate. The importance of mixed substrate over single substrate has been emphasised in the present study. Different mathematical models namely, the Logistic model for cell growth, the Logistic mass balance equation for substrate consumption and the Luedeking-Piret model for β-CRX production were successfully implemented...
January 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/27623933/%C3%AE-cryptoxanthin-reduced-lung-tumor-multiplicity-and-inhibited-lung-cancer-cell-motility-by-downregulating-nicotinic-acetylcholine-receptor-%C3%AE-7-signaling
#20
Anita R Iskandar, Benchun Miao, Xinli Li, Kang-Quan Hu, Chun Liu, Xiang-Dong Wang
Despite the consistent association between a higher intake of the provitamin A carotenoid β-cryptoxanthin (BCX) and a lower risk of lung cancer among smokers, potential mechanisms supporting BCX as a chemopreventive agent are needed. We first examined the effects of BCX on 4-[methyl nitrosamino]-1-[3-pyridyl]-1-butanone (NNK)-induced lung tumorigenesis in A/J mice. BCX supplementation was given daily to the mice starting 2 weeks prior to the injection of NNK and continued 16 weeks after NNK injection. BCX supplementation resulted in a dose-dependent increase of BCX concentration in both serum and lungs of the mice without a significant alteration of vitamin A (retinol and retinyl palmitate) concentration...
November 2016: Cancer Prevention Research
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