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black cohosh

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https://www.readbyqxmd.com/read/29668046/black-cohosh-extracts-and-powders-induce-micronuclei-a-biomarker-of-genetic-damage-in-human-cells
#1
Stephanie L Smith-Roe, Carol D Swartz, Kim G Shepard, Steven M Bryce, Stephen D Dertinger, Suramya Waidyanatha, Grace E Kissling, Scott S Auerbach, Kristine L Witt
Black cohosh extract (BCE) is a widely used dietary supplement marketed to women to alleviate symptoms of gynecological ailments, yet its toxicity has not been well characterized. The National Toxicology Program (NTP) previously reported significant increases in micronucleated erythrocytes in peripheral blood of female Wistar Han rats and B6C3F1/N mice administered 15-1,000 mg BCE/kg/day by gavage for 90 days. These animals also developed a dose-dependent nonregenerative macrocytic anemia characterized by clinical changes consistent with megaloblastic anemia...
April 18, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29627727/quantification-of-the-total-amount-of-black-cohosh-cycloartanoids-by-integration-of-one-specific-1-h-nmr-signal
#2
Serhat Sezai Çiçek, Ulrich Girreser, Christian Zidorn
Quantitative analysis is an important field in the quality control of medicinal plants, aiming to determine the amount of pharmacologically active constituents in complex matrices. Often biological effects of herbal drugs are not restricted to single compounds, but are rather caused by a number of often biogenetically related plant metabolites. Depending on the complexity of the analyzed plant extract, conflicts between accuracy, such as total content assays using photometric or colorimetric methods, and comprehensiveness, e...
March 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29619387/a-comparative-study-on-the-effect-of-black-cohosh-and-evening-primrose-oil-on-menopausal-hot-flashes
#3
Maryam Mehrpooya, Soghra Rabiee, Amir Larki-Harchegani, Amir-Mohammad Fallahian, Abbas Moradi, Sara Ataei, Masoumeh Taravati Javad
INTRODUCTION: Hot flashes are considered to be a common experience for menopausal women and they can compromise the quality of life. The objective of this study is to assess the efficacy of Cimicifuga racemosa in comparison with evening primrose oil (EPO) in postmenopausal women with menopause-related symptoms. MATERIALS AND METHODS: This study was performed on 80 postmenopausal women with hot flashes. The participants were randomly divided into two groups by blocked randomization...
2018: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29600756/potential-pharmacokinetic-herb-drug-interactions-have-we-overlooked-the-importance-of-human-carboxylesterases-1-and-2
#4
Jing Xu, Jin-Chun Qiu, Xing Ji, Hong-Li Guo, Xuan Wang, Bo Zhang, Tengfei Wang, Feng Chen
Herbal products have grown steadily across the globe over the past 10 years and have increasingly been incorporated into western medicine for healthcare aims, thereby causing potential pharmacokinetic herb-drug interactions (HDI) through the inhibition or induction of drug-metabolizing enzymes and transporters. Human carboxylesterases 1 (CES1) and 2 (CES2) are versatile enzymes involvement in the metabolism of endogenous and exogenous compounds including many important therapeutic medications. Moreover, the growing number of CES substrate drugs also underscores the importance of CES1 and CES2...
March 30, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29508091/current-treatment-options-headache-related-to-menopause-diagnosis-and-management
#5
REVIEW
Clinton G Lauritsen, Abigail L Chua, Stephanie J Nahas
PURPOSE OF REVIEW: Menopause is a life-changing event in numerous ways. Many women with migraine hold hope that the transition to the climacteric state will coincide with a cessation or improvement of migraine. This assumption is based mainly on common lay perceptions as well as assertions from many in the healthcare community. Unfortunately, evidence suggests this is far from the rule. Many women turn to a general practitioner or a headache specialist for prognosis and management. A natural instinct is to manipulate the offending agent, but in some cases, this approach backfires, or the concern for adverse events outweighs the desire for a therapeutic trial, and other strategies must be pursued...
March 6, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29464801/herbal-medicine-for-depression-and-anxiety-a-systematic-review-with-assessment-of-potential-psycho-oncologic-relevance
#6
REVIEW
K Simon Yeung, Marisol Hernandez, Jun J Mao, Ingrid Haviland, Jyothirmai Gubili
Anxiety and depression are prevalent among cancer patients, with significant negative impact. Many patients prefer herbs for symptom relief to conventional medications which have limited efficacy/side effects. We identified single-herb medicines that may warrant further study in cancer patients. Our search included PubMed, Allied and Complementary Medicine, Embase, and Cochrane databases, selecting only single-herb randomized controlled trials between 1996 and 2016 in any population for data extraction, excluding herbs with known potential for interactions with cancer treatments...
February 21, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29403626/a-review-of-effective-herbal-medicines-in-controlling-menopausal-symptoms
#7
REVIEW
Rahele Kargozar, Hoda Azizi, Roshanak Salari
Background: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. Objective: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29403307/the-effects-of-black-cohosh-on-the-regulation-of-estrogen-receptor-er%C3%AE-and-progesterone-receptor-pr-in-breast-cancer-cells
#8
Monica Szmyd, Victoria Lloyd, Kelly Hallman, Katie Aleck, Viktoria Mladenovik, Christina McKee, Mia Morse, Tyler Bedgood, Sumi Dinda
The North American plant Cimicifuga racemosa, also known as black cohosh (BC), is a herb that recently has gained attention for its hormonal effects. As the usage of hormone replacement therapy is declining due to its adverse effects in women with cancer, many are turning to herbal remedies like BC to treat menopausal symptoms. It is crucial to determine whether the effects of BC involve estrogen receptor-alpha (ERα). Previous studies from our laboratory have shown ERα to be a possible molecular target for BC...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29348843/actein-induces-autophagy-and-apoptosis-in-human-bladder-cancer-by-potentiating-ros-jnk-and-inhibiting-akt-pathways
#9
Lu Ji, Bing Zhong, Xi Jiang, Fei Mao, Gang Liu, Bin Song, Cheng-Yuan Wang, Yong Jiao, Jiang-Ping Wang, Zhi-Bin Xu, Xing Li, Bo Zhan
Human bladder cancer is a common genitourinary malignant cancer worldwide. However, new therapeutic strategies are required to overcome its stagnated survival rate. Triterpene glycoside Actein (ACT), extracted from the herb black cohosh, suppresses the growth of human breast cancer cells. Our study attempted to explore the role of ACT in human bladder cancer cell growth and to reveal the underlying molecular mechanisms. We found that ACT significantly impeded the bladder cancer cell proliferation via induction of G2/M cycle arrest...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29323578/effects-of-black-cohosh-and-estrogen-on-core-body-and-tail-skin-temperatures-in-ovariectomized-rats-by-telemetric-monitoring-with-dual-thermistor-probes
#10
Y Sun, L H Qin, X Chen, X Yan, L Mao, W Bai, J Kang
OBJECTIVES: To investigate the effects of black cohosh and estrogen on the temperature in ovariectomized rats, the core body temperature (CBT) and tail-skin temperature (TST) were simultaneously monitored and the relationship between these two temperatures was explored. METHODS: Twenty-four female Sprague-Dawley rats aged 8 weeks were randomly divided into four groups: sham-operated (SHAM), ovariectomized (OVX), OVX treated with estradiol valerate (OVX + E), and OVX treated with isopropanolic black cohosh extract (OVX + ICR)...
April 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29232609/influence-of-direct-and-sequential-extraction-methodology-on-metabolic-profiling
#11
K M Maria John, James Harnly, Devanand Luthria
A systematic comparison was made of the detected metabolite profiles for two plant materials (black beans and soybeans) and a dietary supplement (black cohosh) extracted using sequential (hexane, ethyl acetate, and 50% aqueous methanol) and direct extraction with three solvent systems (80% aqueous methanol, methanol/chloroform/water (2.5:1:1, v/v/v) and water). Extracts were analyzed by LC-MS (without derivatization) and GC-FID (with BSTFA/TMCS derivatizations). For sequential extraction, HPLC-UV and BSTFA/TMCS-derivatized GC-FID detection were more responsive to the polar molecules with a rough distribution of 10%, 10%, and 80% of the total signals in hexane, ethyl acetate, and 50% aqueous methanol, respectively...
January 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29156534/effects-of-standardized-isopropanolic-black-cohosh-and-estrogen-on-salivary-function-in-ovariectomized-rats
#12
Shuya Liu, Kaiyu Niu, Yunmeng Da, Yao Liu, Jing Zhang, Wenjuan Wang, Yi Zhang, Hai Jiang, Ke Wang, Wenpei Bai, Lihua Qin, Jing Jia
Oral dryness is a common feature in menopausal women. Estrogen therapy can relieve this symptom; however, the underlying mechanism was not clear. Standardized isopropanolic black cohosh (Actaea racemosa; Remifemin) can also relieve menopausal symptoms, such as hot flashes and sweating. Our previous study showed that standardized isopropanolic black cohosh could protect the submandibular gland structure. To investigate the effects and possible mechanisms of action of estrogen and standardized isopropanolic black cohosh on submandibular gland function in ovariectomized (OVX) rats, we measured body weight, daily water consumption, and blood flow in the submandibular glands...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28985643/hyperspectral-imaging-and-support-vector-machine-a-powerful-combination-to-differentiate-black-cohosh-actaea-racemosa-from-other-cohosh-species
#13
Sidonie Tankeu, Ilze Vermaak, Weiyang Chen, Maxleene Sandasi, Guy Kamatou, Alvaro Viljoen
Actaea racemosa (black cohosh) has a history of traditional use in the treatment of general gynecological problems. However, the plant is known to be vulnerable to adulteration with other cohosh species. This study evaluated the use of shortwave infrared hyperspectral imaging (SWIR-HSI) in tandem with chemometric data analysis as a fast alternative method for the discrimination of four cohosh species (Actaea racemosa, Actaea podocarpa, Actaea pachypoda, Actaea cimicifuga) and 36 commercial products labelled as black cohosh...
October 6, 2017: Planta Medica
https://www.readbyqxmd.com/read/28975316/review-in-menopause-intact-uterus-estrogen-progestogen-isoflavones-and-black-cohosh-reduce-hot-flashes
#14
COMMENT
Dennis G Maki
No abstract text is available yet for this article.
September 19, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28836330/actein-alleviates-2-3-7-8-tetrachlorodibenzo-p-dioxin-mediated-cellular-dysfunction-in-osteoblastic-mc3t3-e1-cells
#15
Eun Mi Choi, Kwang Sik Suh, Woon-Won Jung, So Young Park, Sang Ouk Chin, Sang Youl Rhee, Youngmi Kim Pak, Suk Chon
The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to affect bone metabolism. We evaluated the protective effects of the triterpene glycoside actein from the herb black cohosh against TCDD-induced toxicity in MC3T3-E1 osteoblastic cells. We found that TCDD significantly reduced cell viability and increased apoptosis and autophagy in MC3T3-E1 osteoblastic cells (P < .05). In addition, TCDD treatment resulted in a significant increase in intracellular calcium concentration, mitochondrial membrane potential collapse, reactive oxygen species (ROS) production, and cardiolipin peroxidation, whereas pretreatment with actein significantly mitigated these effects (P < ...
December 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28762712/common-herbal-dietary-supplement-drug-interactions
#16
REVIEW
Gary N Asher, Amanda H Corbett, Roy L Hawke
Nearly 25% of U.S. adults report concurrently taking a prescription medication with a dietary supplement. Some supplements, such as St. John's wort and goldenseal, are known to cause clinically important drug interactions and should be avoided by most patients receiving any pharmacologic therapy. However, many other supplements are predicted to cause interactions based only on in vitro studies that have not been confirmed or have been refuted in human clinical trials. Some supplements may cause interactions with a few medications but are likely to be safe with other medications (e...
July 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28627583/deoxyactein-protects-pancreatic-%C3%AE-cells-against-methylglyoxal-induced-oxidative-cell-damage-by-the-upregulation-of-mitochondrial-biogenesis
#17
Kwang Sik Suh, Eun Mi Choi, Woon-Won Jung, Yu Jin Kim, Soo Min Hong, So Yong Park, Sang Youl Rhee, Suk Chon
Methylglyoxal (MG) is one of the major precursors of advanced glycation end products (AGEs), which are considered to be one of the causes of diabetes and its complications. The root and rhizomes of black cohosh (Cimicifuga racemosa) have long been used medicinally, and deoxyactein is one of its major constituents. In the present study, the protective effects of deoxyactein against MG-induced oxidative cell damage were investigated in insulin-producing pancreatic β-cells. We found that deoxyactein protected the pancreatic β-cells against MG-induced cell death...
June 12, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28618975/a-black-cohosh-extract-causes-hematologic-and-biochemical-changes-consistent-with-a-functional-cobalamin-deficiency-in-female-b6c3f1-n-mice
#18
Michelle C Cora, William Gwinn, Ralph Wilson, Debra King, Suramya Waidyanatha, Grace E Kissling, Sukhdev S Brar, Dorian Olivera, Chad Blystone, Greg Travlos
Black cohosh rhizome, available as a dietary supplement, is most commonly marketed as a remedy for dysmenorrhea and menopausal symptoms. A previous subchronic toxicity study of black cohosh dried ethanolic extract (BCE) in female mice revealed a dose-dependent ineffective erythropoiesis with a macrocytosis consistent with the condition known as megaloblastic anemia. The purpose of this study was to investigate potential mechanisms by which BCE induces these particular hematological changes. B6C3F1/N female mice (32/group) were exposed by gavage to vehicle or 1,000 mg/kg BCE for 92 days...
July 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28561959/review-of-efficacy-of-complementary-and-alternative-medicine-treatments-for-menopausal-symptoms
#19
REVIEW
Thea R Moore, Rachel B Franks, Carol Fox
Complementary and alternative medicine (CAM) treatments have been used for thousands of years around the world. There has been increased interest in utilizing CAM for menopausal symptoms since the release of results of the Women's Health Initiative elucidated long-term adverse effects associated with hormone therapy. Women looking for more natural or safer means to treat hot flushes, night sweats, and other menopausal symptoms often turn to CAM such as yoga, phytoestrogens, or black cohosh. Yet there have been few well-conducted studies looking at the efficacy of these treatments...
May 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28546801/the-safety-and-tolerance-of-phytotherapies-in-menopausal-medicine-a-review-of-the-literature
#20
REVIEW
Piotr Czuczwar, Tomasz Paszkowski, Marek Lisiecki, Sławomir Woźniak, Anna Stępniak
Phytoestrogens are polyphenol, non-steroidal substances of plant origin, resembling 17β-estradiol in structure. These substances can act as either agonists or antagonists of oestrogen receptors α and β. Phytoestrogens are widely used to alleviate menopausal symptoms, such as hot flushes and night sweats. Most of the currently available products of plant origin registered to soften climacteric symptoms consist of extracts obtained from soy, red clover, or black cohosh. Non-hormonal phytotherapy is a new alternative for patients suffering from menopausal symptoms...
March 2017: Przeglad Menopauzalny, Menopause Review
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