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https://www.readbyqxmd.com/read/28503051/an-update-review-on-the-anthelmintic-activity-of-bitter-gourd-momordica-charantia
#1
REVIEW
Sutthaya Poolperm, Wannee Jiraungkoorskul
Momordica charantia (Family: Cucurbitales), as known as bitter melon or gourd, is a daily consumption as food and traditional medicinal plant in Southeast Asia and Indo-China. It has been shown to possess anticancer, antidepressant, antidiabetic, anti-inflammatory, antimicrobial, antiobesity, antioxidant, and antiulcer properties. Its common phytochemical components include alkaloids, charantin, flavonoids, glycosides, phenolics, tannins, and terpenoids. This plant is rich in various saponins including momordicin, momordin, momordicoside, karavilagenin, karaviloside, and kuguacin, all of which have been reported to contribute to its remedial properties including antibacterial, antifungal, antiviral, and antiparasitic infections...
January 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28465362/bitter-melon-enhances-natural-killer-mediated-toxicity-against-head-and-neck-cancer-cells
#2
Sourav Bhattacharya, Naoshad Muhammd, Robert Steele, Jacki Kornbluth, Ratna B Ray
Natural Killer (NK) cells are one of the major components of innate immunity, with the ability to mediate antitumor activity. Understanding the role of NK cell mediated tumor killing in controling of solid tumor growth is still in the developmental stage. We have shown recently that bitter melon extract (BME) modulates the regulatory T cell (Treg) population in head and neck squamous cell carcinoma (HNSCC). However, the role of BME in NK cell modulation against HNSCC remains unknown. In this study, we investigated whether BME can enhance the NK cell killing activity against HNSCC cells...
May 2, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28371276/separation-of-cucurbitane-triterpenoids-from-bitter-melon-drinks-and-determination-of-partition-coefficients-using-vortex-assisted-dispersive-liquid-phase-microextraction-followed-by-uhplc-analysis
#3
Shuang Hu, Yan-Hong Wang, Bharathi Avula, Mei Wang, Ikhlas A Khan
A rapid, effective method applying vortex-assisted liquid-liquid microextraction before ultra-high performance liquid chromatography with mass spectrometry and evaporative light scattering detection was developed for the analysis of four cucurbitane triterpenoids (momordicoside L, momordicoside K, momordicoside F2 , and 3β,7β,25-trihydroxy cucurbita-5,23(E)-dien-19-al) in bitter melon juices. Variables affecting the extraction efficiency including different extraction solvents, volume of extraction solvent, salt amount, acid condition, vortex speed and time were optimized thoroughly...
March 31, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28335529/effects-of-momordica-charantia-bitter-melon-on-ischemic-diabetic-myocardium
#4
Attila Czompa, Alexandra Gyongyosi, Kitti Szoke, Istvan Bak, Evelin Csepanyi, David D Haines, Arpad Tosaki, Istvan Lekli
Objective: A rat model is here used to test a hypothesis that Momordica charantia (Bitter melon (BM)) extract favorably alters processes in cardiovascular tissue and is systemically relevant to the pathophysiology of type 2 diabetes (T2DM) and related cardiovascular disease. Methods: Male Lean and Zucker Obese (ZO) rats were gavage-treated for six weeks with 400 mg/kg body weight bitter melon (BM) extract suspended in mucin-water vehicle, or with vehicle (Control). Animals were segregated into four treatment groups, 10 animals in each group, according to strain (Lean or ZO) and treatment (Control or BM)...
March 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28092345/acute-effects-of-a-beverage-containing-bitter-melon-extract-carela-on-postprandial-glycemia-among-prediabetic-adults
#5
C H Boone, J R Stout, J A Gordon, M J Redd, D D Church, L P Oliveira, D H Fukuda, J R Hoffman
BACKGROUND: Acute ingestion of bitter melon (BM) has been shown to suppress the postprandial glycemic response in diabetics, but its impact on glucose regulation among individuals with impaired glucose tolerance is unclear. Moreover, one's glucose tolerance level may influence the effectiveness of BM. This study aimed to examine the acute effects of a beverage containing BM extract on blood glucose regulation during an oral glucose tolerance test (OGTT) among prediabetics. METHODS: Ten prediabetic adults completed two OGTTs-glucose only (D2) and glucose+BM (D3)...
January 16, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28049460/bitter-melon-protects-against-er-stress-in-ls174t-colonic-epithelial-cells
#6
Dale A Kunde, Wai Chin Chong, Prathiba V Nerurkar, Kiran D K Ahuja, Jeremy Just, Jason A Smith, Nuri Guven, Rajaraman D Eri
BACKGROUND: Bitter Melon (BM) has been used as a functional food in traditional Chinese and Indian medicine for many generations and has gained a great deal of attention due to its apparent benefits in moderating some of the pathogenic processes in a variety of inflammatory conditions. BM extract (BME) has been shown to possess strong anti-oxidant properties. In addition, it can ameliorate oxidative stress and potentially ER stress. There is increasing evidence that oxidative and ER stress are major contributors for intestinal secretory cell dysfunction which leads to local inflammation and disease pathogenesis that are hallmarks of inflammatory bowel diseases (IBD)...
January 3, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28028039/draft-genome-sequence-of-bitter-gourd-momordica-charantia-a-vegetable-and-medicinal-plant-in-tropical-and-subtropical-regions
#7
Naoya Urasaki, Hiroki Takagi, Satoshi Natsume, Aiko Uemura, Naoki Taniai, Norimichi Miyagi, Mai Fukushima, Shouta Suzuki, Kazuhiko Tarora, Moritoshi Tamaki, Moriaki Sakamoto, Ryohei Terauchi, Hideo Matsumura
Bitter gourd (Momordica charantia) is an important vegetable and medicinal plant in tropical and subtropical regions globally. In this study, the draft genome sequence of a monoecious bitter gourd inbred line, OHB3-1, was analyzed. Through Illumina sequencing and de novo assembly, scaffolds of 285.5 Mb in length were generated, corresponding to ∼84% of the estimated genome size of bitter gourd (339 Mb). In this draft genome sequence, 45,859 protein-coding gene loci were identified, and transposable elements accounted for 15...
February 1, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/27984270/bitter-melon-extract-promotes-granulation-tissue-growth-and-angiogenesis-in-the-diabetic-wound
#8
COMPARATIVE STUDY
Rekha Singh, Ignacio Garcia-Gomez, Krishnamurthy P Gudehithlu, Ashok K Singh
OBJECTIVE: Bitter melon is a plant fruit that has been shown to exert a hypoglycemic effect when used systemically in patients with diabetes. This study was designed to investigate the topical effect of bitter melon on diabetic wounds using the wound chamber model in rats. DESIGN: Two bilateral wound chambers were implanted subcutaneously in the thoracic-lumbar region of male Sprague-Dawley rats. Diabetes was induced with streptozotocin 7 days after implantation of wound chambers...
January 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/27975394/investigation-of-an-edible-tcm-bitter-melon-momordica-charantia-metabolite-profiling-differentiation-and-characterization
#9
S Zhou, Y Ye, A Afzan, P M Allard, C Wolfrum, J L Wolfender
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27973445/roles-of-peroxisome-proliferator-activated-receptor-%C3%AE-in-bitter-melon-seed-oil-corrected-lipid-disorders-and-conversion-of-%C3%AE-eleostearic-acid-into-rumenic-acid-in-c57bl-6j-mice
#10
Ya-Yuan Chang, Hui-Min Su, Szu-Han Chen, Wen-Tsong Hsieh, Jong-Ho Chyuan, Pei-Min Chao
We previously reported that bitter melon seed oil (BMSO) was an effective anti-steatosis and antiobesity agent. Since the major fatty acid α-eleostearic acid (α-ESA) in BMSO is a peroxisome proliferator-activated receptor α (PPARα) activator, the objective was to investigate the role of PPARα in BMSO-modulated lipid disorders and α-ESA metabolism. C57BL/6J wild (WD) and PPARα knockout (KO) mice were fed a high-fat diet containing BMSO (15% soybean oil + 15% BMSO, HB) or not (30% soybean oil, HS) for 5 weeks...
December 12, 2016: Nutrients
https://www.readbyqxmd.com/read/27892922/convergence-and-divergence-of-bitterness-biosynthesis-and-regulation-in-cucurbitaceae
#11
Yuan Zhou, Yongshuo Ma, Jianguo Zeng, Lixin Duan, Xiaofeng Xue, Huaisong Wang, Tao Lin, Zhiqiang Liu, Kewu Zeng, Yang Zhong, Shu Zhang, Qun Hu, Min Liu, Huimin Zhang, James Reed, Tessa Moses, Xinyan Liu, Peng Huang, Zhixing Qing, Xiubin Liu, Pengfei Tu, Hanhui Kuang, Zhonghua Zhang, Anne Osbourn, Dae-Kyun Ro, Yi Shang, Sanwen Huang
Differentiation of secondary metabolite profiles in closely related plant species provides clues for unravelling biosynthetic pathways and regulatory circuits, an area that is still underinvestigated. Cucurbitacins, a group of bitter and highly oxygenated tetracyclic triterpenes, are mainly produced by the plant family Cucurbitaceae. These compounds have similar structures, but differ in their antitumour activities and ecophysiological roles. By comparative analyses of the genomes of cucumber, melon and watermelon, we uncovered conserved syntenic loci encoding metabolic genes for distinct cucurbitacins...
November 28, 2016: Nature Plants
https://www.readbyqxmd.com/read/27878888/metabolomics-reveals-that-momordica-charantia-attenuates-metabolic-changes-in-experimental-obesity
#12
Zhi-Gang Gong, Jianbing Zhang, Yong-Jiang Xu
Momordica charantia L., also known as bitter melon, has been shown to ameliorate obesity and insulin resistance. However, metabolic changes regulated by M. charantia in obesity are not clearly understood. In this study, serums obtained from obese and M. charantia-treated mice were analyzed by using gas and liquid chromatography-mass spectrometry, and multivariate statistical analysis was performed by Orthogonal partial least squares discriminant analysis. The results from this study indicated that body weight fat and insulin levels of obese mice are dramatically suppressed by 8 weeks of dietary supplementation of M...
February 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27852126/traditional-chinese-medicine-food-therapy-and-hypertension-control-a-narrative-review-of-chinese-literature
#13
REVIEW
Ping Zou
Despite the lack of English literature about Traditional Chinese Medicine (TCM) food therapy, there is abundant Chinese literature about the application of food therapy for hypertension control. This paper summarizes basic concepts of TCM, the principles of food therapy and its application for hypertension control according to Chinese literature. In TCM, food is conceptualized according to both nutritional and functional aspects, and can be used to treat illnesses. Four principles of TCM food therapy including light eating, balancing the "hot" and "cold" nature of food, the harmony of the five flavors of food, and consistency between dietary intake and different health conditions, can be used to facilitate hypertension control...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27751827/response-of-gut-microbiota-and-inflammatory-status-to-bitter-melon-momordica-charantia-l-in-high-fat-diet-induced-obese-rats
#14
Juan Bai, Ying Zhu, Ying Dong
ETHNOPHARMACOLOGICAL RELEVANCE: Bitter melon (Momordica charantia L.) is rich in a variety of biologically active ingredients, and has been widely used in traditional Chinese medicine (TCM) to treat various diseases, including type 2 diabetes and obesity. AIM OF THE STUDY: We aimed to investigate how bitter melon powder (BMP) could affect obesity-associated inflammatory responses to ameliorate high-fat diet (HFD)-induced insulin resistance, and investigated whether its anti-inflammatory properties were effected by modulating the gut microbiota...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27610171/influence-of-total-anthocyanins-from-bitter-melon-momordica-charantia-linn-as-antidiabetic-and-radical-scavenging-agents
#15
Aytaç Güdr
The majority of the antioxidant and antidiabetic activities of fruits are anthocyanins; a group of polyphenolics that are responsible for the color of many fruits, vegetables and flowers. The harvesting time, storage conditions, maturity, extraction steps etc. are very important for the biological activities based on the alteration of chemical composition. The free radical scavenging and antidiabetic activities of total anthocyanins from bitter melon (Momordica charantia Linn) fruit (TAMC) were evaluated by considering four harvesting times...
2016: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/27593811/postlaminectomy-bone-and-scar-formations-in-presence-of-ankaferd-blood-stopper-and-bitter-melon-momordica-charantia-an-experimental-study
#16
Enis Kuruoglu, Mehmet Emin Onger, Abdullah Hilmi Marangoz, Suleyman Emre Kocacan, Cengiz Cokluk, Suleyman Kaplan
AIM: In the present study, a quantitative model of post-laminectomy in rats was designed. Concurrently, the effects of Momordica charantia (MC) and Ankaferd blood stopper (ABS) were evaluated. MATERIAL AND METHODS: Eighteen adult Wistar albino rats underwent lumbar laminectomy at L2-L3 vertebral levels, and were randomly assigned to one of three groups of six rats each. The treatment group received MC and ABS treatment and the Control group was untreated. Rats were sacrificed 4 weeks after treatment...
February 5, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27538854/-1-h-nmr-based-metabolic-study-reveals-the-improvements-of-bitter-melon-momordica-charantia-on-energy-metabolism-in-diet-induced-obese-mouse
#17
Hui-Xi Bian, Ze-Yu Wu, Bin Bao, Jing Cai, Xin Wang, Ying Jiang, Jian Liu, Wei Qu
CONTEXT: Obesity can be ameliorated by some natural products such as polyphenol, flavones and saponin. As a typical medicinal plant, Momordica charantia L. (Cucurbitaceae) (bitter melon, BM) contains these natural chemicals and reduces diet-induced obesity in mice. OBJECTIVE: This study evaluates the metabolic effects of dietary BM supplement, investigates a global metabolic profile and determines associated perturbations in metabolic pathways. MATERIALS AND METHODS: Male C57BL/6 mice were fed with low-fat diet (LFD), high-fat diet (HFD) and HFD supplemented with 5% BM based on 37...
December 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27513747/antiglycation-and-antioxidant-properties-of-momordica-charantia
#18
Ali Aljohi, Sabine Matou-Nasri, Nessar Ahmed
The accumulation of advanced glycation endproducts (AGEs) and oxidative stress underlie the pathogenesis of diabetic complications. In many developing countries, diabetes treatment is unaffordable, and plants such as bitter gourd (or bitter melon; Momordica charantia) are used as traditional remedies because they exhibit hypoglycaemic properties. This study compared the antiglycation and antioxidant properties of aqueous extracts of M. charantia pulp (MCP), flesh (MCF) and charantin in vitro. Lysozyme was mixed with methylglyoxal and 0-15 mg/ml of M...
2016: PloS One
https://www.readbyqxmd.com/read/27498497/variation-in-antioxidant-enzyme-activities-growth-and-some-physiological-parameters-of-bitter-melon-momordica-charantia-under-salinity-and-chromium-stress
#19
Mahsa Bahrami, Mostafa Heidari, Hadi Ghorbani
In general, salinity and heavy metals interfere with several physiological processes and reduce plant growth. In order to evaluate of three levels of salinity (0, 4 and 8 ds m(-1)) and three concentration of chromium (0, 10 and 20 mg kg(-1) soil) in bitter melon (Momordica charantia), a plot experiment was conducted in greenhouse at university of Shahrood, Iran. The results revealed that chromium treatment had no significant affect on fresh and dry weight, but salinity caused reduction of fresh and dry weight in growth parameter...
July 2016: Journal of Environmental Biology
https://www.readbyqxmd.com/read/27452666/promise-of-bitter-melon-momordica-charantia-bioactives-in-cancer-prevention-and-therapy
#20
REVIEW
Komal Raina, Dileep Kumar, Rajesh Agarwal
Recently, there is a paradigm shift that the whole food-derived components are not 'idle bystanders' but actively participate in modulating aberrant metabolic and signaling pathways in both healthy and diseased individuals. One such whole food from Cucurbitaceae family is 'bitter melon' (Momordica charantia, also called bitter gourd, balsam apple, etc.), which has gained an enormous attention in recent years as an alternative medicine in developed countries. The increased focus on bitter melon consumption could in part be due to several recent pre-clinical efficacy studies demonstrating bitter melon potential to target obesity/type II diabetes-associated metabolic aberrations as well as its pre-clinical anti-cancer efficacy against various malignancies...
October 2016: Seminars in Cancer Biology
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