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https://www.readbyqxmd.com/read/28721824/potential-anti-inflammatory-effects-of-hesperidin-from-the-genus-citrus
#1
Silvia Tejada, Samuel Pinya, Miquel Martorell, Xavier Capó, Josep A Tur, Antoni Pons, Antoni Sureda
The benefits of the Mediterranean diet for protecting against many diseases are usually attributed to high consumption of certain foods, characterized by the presence of bioactive substances such as polyphenols. Citrus fruits, which are cultivated and consumed worldwide, are typical products of the Mediterranean diet. Inflammation plays an important role in the pathogenesis of numerous diseases such as arthritis, allergies and neurodegenerative disorders, among others. Dietary polyphenols constitute a large family of bioactive substances with potential beneficial effects against a broad group of diseases...
July 18, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28718686/kinetic-study-on-the-inhibition-of-xanthine-oxidase-by-acylated-derivatives-of-flavonoids-synthesised-enzymatically
#2
Maria Elisa Melo Branco de Araújo, Yollanda Edwirges Moreira Franco, Thiago Grando Alberto, Marcia Cristina Fernandes Messias, Camila Wielewski Leme, Alexandra Christine Helena Frankland Sawaya, Patricia de Oliveira Carvalho
Studies have reported that flavonoids inhibit xanthine oxidase (XO) activity; however, poor solubility and stability in lipophilic media limit their bioavailability and applications. This study evaluated the kinetic parameters of XO inhibition and partition coefficients of flavonoid esters biosynthesised from hesperidin, naringin, and rutin via enzymatic acylation with hexanoic, octanoic, decanoic, lauric, and oleic acids catalysed by Candida antarctica lipase B (CALB). Quantitative determination by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) showed higher conversion yields (%) for naringin and rutin esters using acyl donors with 8C and 10C...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28686835/various-antioxidant-effects-were-attributed-to-different-components-in-the-dried-blossoms-of-citrus-aurantium-l-var-amara-engl
#3
Chun-Yan Shen, Tian-Xing Wang, Xi-Mei Zhang, Jian-Guo Jiang
Citrus aurantium L. var. amara Engl. (CAVA) was traditionally used as edible and medicinal material in China. Total flavonoids (CAVAF), alkaloids (CAVAA), polysaccharides (CAVAP), coumarins (CAVAC) and neroli (CAVAO) were extracted from CAVA. Hesperidin, naringin and neohesperidin composed 83.94% of CAVAF, and synephrine represented 50.56% of CAVAA. Based on 1,1-diphenyl-2-picrylhydrazyl radical (DPPH•), 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt radical cation (ABTS•+), hydroxyl radical (•OH), ferric-reducing antioxidant power (FRAP) and reducing power assays, the antioxidant activities of five components were comprehensively and comparatively investigated...
July 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28686312/flavonoid-composition-of-tarocco-citrus-sinensis-l-osbeck-clone-lempso-and-fast-antioxidant-activity-screening-by-dpph-uhplc-pda-it-tof
#4
Eduardo Sommella, Francesco Pagano, Giacomo Pepe, Carmine Ostacolo, Michele Manfra, Marcello Chieppa, Rosa Di Sanzo, Sonia Carabetta, Pietro Campiglia, Mariateresa Russo
INTRODUCTION: Clonal selection and hybridisation are valid strategies to obtain fruits with enhanced sensorial and nutraceutical properties. Within Citrus sinensis varieties, Tarocco clone "Lempso" is a typical product of the Calabria region (Italy) characterised by its red pulp. This is the first report concerning its accurate profiling. OBJECTIVE: To characterise in detail the flavonoid composition of Lempso clone and to compare its antioxidant potential with other Citrus varieties by a fast screening method...
July 7, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28682120/comparison-of-the-effects-of-dietary-supplementation-of-flavonoids-on-laying-hen-performance-egg-quality-and-egg-nutrient-profile
#5
H Iskender, G Yenice, E Dokumacioglu, O Kaynar, A Hayırlı, A Kaya
1. The aim of this experiment was to compare the effects of dietary supplementation of hesperidin, naringin and quercetin on laying hen performance, egg quality and egg yolk lipid and protein profiles. A total of 96 Lohmann White laying hens weighing an average of 1500 g at 28 weeks of age were randomly assigned to a basal diet and the basal diet supplemented (0.5 g/kg) with either hesperidin, naringin or quercetin. Each treatment was replicated in 6 cages in an 8-week experimental period. Data were analysed using one-way ANOVA...
July 6, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28659786/flavonoid-hesperidin-induces-synapse-formation-and-improves-memory-performance-through-the-astrocytic-tgf-%C3%AE-1
#6
Isadora Matias, Luan P Diniz, Andrea Buosi, Gilda Neves, Joice Stipursky, Flávia Carvalho Alcantara Gomes
Synapse formation and function are critical events for the brain function and cognition. Astrocytes are active participants in the control of synapses during development and adulthood, but the mechanisms underlying astrocyte synaptogenic potential only began to be better understood recently. Currently, new drugs and molecules, including the flavonoids, have been studied as therapeutic alternatives for modulation of cognitive processes in physiological and pathological conditions. However, the cellular targets and mechanisms of actions of flavonoids remain poorly elucidated...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28657497/hesperidin-attenuates-inflammation-and-oxidative-damage-in-pleural-exudates-and-liver-of-rat-model-of-pleurisy
#7
Stephen Adeniyi Adefegha, Daniela Bitencourt Rosa Leal, Ayodeji Augustine Olabiyi, Ganiyu Oboh, Livia Gelain Castilhos
OBJECTIVES: This study investigated the potential anti-inflammatory effect of hesperidin against carrageenan induced pleurisy in rat model. METHODS: Twenty-four adult female Wistar rats (350 - 450g) were grouped as follows: Group I: rats were administered saline solution only (Normal control group); Group II: rats were administered saline solution (NaCl 0.9%) orally and injected with carrageenan (Inflammation control group); Group III: rats were administered hesperidin only (Hesperidin group); Group IV: rats were administered hesperidin orally and intrapleurally injected with 2% carrageenan (Inflammation treated with hesperidin group)...
June 28, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28643618/heat-stabilised-rice-bran-consumption-by-colorectal-cancer-survivors-modulates-stool-metabolite-profiles-and-metabolic-networks-a-randomised-controlled-trial
#8
Dustin G Brown, Erica C Borresen, Regina J Brown, Elizabeth P Ryan
Rice bran (RB) consumption has been shown to reduce colorectal cancer (CRC) growth in mice and modify the human stool microbiome. Changes in host and microbial metabolism induced by RB consumption was hypothesised to modulate the stool metabolite profile in favour of promoting gut health and inhibiting CRC growth. The objective was to integrate gut microbial metabolite profiles and identify metabolic pathway networks for CRC chemoprevention using non-targeted metabolomics. In all, nineteen CRC survivors participated in a parallel randomised controlled dietary intervention trial that included daily consumption of study-provided foods with heat-stabilised RB (30 g/d) or no additional ingredient (control)...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28627244/a-comparative-study-of-mentha-arvensis-l-and-mentha-haplocalyx-briq-by-hplc
#9
Bing Tian Zhao, Tae In Kim, Young Ho Kim, Jong Seong Kang, Byung Sun Min, Jong Keun Son, Mi Hee Woo
We have developed a new method to simultaneously determine five marker compounds in Menthae Herba via HPLC/PDA - including hesperidin (1), rosmarinic acid (2), diosmin (3), didymin (4) and buddleoside (5). The newly developed method was successfully used to analyse for two species (Mentha arvensis L. and Mentha haplocalyx Briq.) of Menthae Herba, and the satisfactory results were obtained from the validation of developed method. The pattern analysis could greatly discriminate between M. arvensis L. and M. haplocalyx Briq...
June 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28620169/structural-insight-for-the-recognition-of-g-quadruplex-structure-at-human-c-myc-promoter-sequence-by-flavonoid-quercetin
#10
Arpita Tawani, Subodh Kumar Mishra, Amit Kumar
Small molecule ligands that could stabilize G-quadruplex structure formed at the promoter region of human c-myc oncogene will regulate its expression in cancer cells. Flavonoids, a group of naturally available small molecule, have been known for their various promising effects on human health. In present study, we have performed detailed biophysical studies for the interaction of human c-myc G-quadruplex DNA with nine representative flavonoids: Luteolin, Quercetin, Rutin, Genistein, Kaempferol, Puerarin, Hesperidin, Myricetin and Daidzein...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28596796/hesperidin-protects-against-acute-alcoholic-injury-through-improving-lipid-metabolism-and-cell-damage-in-zebrafish-larvae
#11
Zhenting Zhou, Weichao Zhong, Haiyan Lin, Peng Huang, Ning Ma, Yuqing Zhang, Chuying Zhou, Yuling Lai, Shaohui Huang, Shiying Huang, Lei Gao, Zhiping Lv
Alcoholic liver disease (ALD) is a series of abnormalities of liver function, including alcoholic steatosis, steatohepatitis, and cirrhosis. Hesperidin, the major constituent of flavanone in grapefruit, is proved to play a role in antioxidation, anti-inflammation, and reducing multiple organs damage in various animal experiments. However, the underlying mechanism of resistance to alcoholic liver injury is still unclear. Thus, we aimed to investigate the protective effects of hesperidin against ALD and its molecular mechanism in this study...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28587283/influence-of-hesperidin-on-the-systemic-and-intestinal-rat-immune-response
#12
Mariona Camps-Bossacoma, Àngels Franch, Francisco J Pérez-Cano, Margarida Castell
Polyphenols, widely found in edible plants, influence the immune system. Nevertheless, the immunomodulatory properties of hesperidin, the predominant flavanone in oranges, have not been deeply studied. To establish the effect of hesperidin on in vivo immune response, two different conditions of immune system stimulations in Lewis rats were applied. In the first experimental design, rats were intraperitoneally immunized with ovalbumin (OVA) plus Bordetella pertussis toxin and alum as the adjuvants, and orally given 100 or 200 mg/kg hesperidin...
June 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28578029/investigation-of-the-interaction-for-three-citrus-flavonoids-and-%C3%AE-amylase-by-surface-plasmon-resonance
#13
Xia Liu, Fang Luo, Pao Li, Yin She, Wanru Gao
Flavonoids, a class of natural drugs with broad biological activity, exhibit inhibitory effect on α-amylase. Citrus peel is a good source of flavonoids. The real-time interactions between three Citrus flavonoids (naringin, neohesperidin, hesperidin) and α-amylase were investigated by surface plasmon resonance biosensor, and were compared with the α-amylase inhibitors, acarbose. These results showed the binding affinities of naringin, neohesperidin and hesperidin with α-amylase reach the highest at pH6 with KD values of 2...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28573351/mitigating-potential-of-melissa-officinale-against-as-3-induced-cytotoxicity-and-transcriptional-alterations-of-hsp70-and-hsp27-in-fish-channa-punctatus-bloch
#14
Shraddha Dwivedi, Manoj Kumar, Sunil P Trivedi
The mitigating potential of Melissa officinale (MO) (Lamiaceae) against arsenite (As(3+))-induced oxidative stress, cytogenotoxicity, and expression of stress genes in fish, Channa punctatus (Bloch), teleost, was explored. After confirming the composition of MO extract, caffeic acid (0.96%), hesperidin (1.73%), naringenin (7.70%), lutenolin (3.29%), kaempferol (11.46%) and hesperetin (6.24%), by HPLC-PDA analysis, the experiment was set up in six groups (G1-G6), each containing 10 specimens. Blood, muscle, gills and liver tissues of control and treated fishes were excised at an interval of 24 till 96 h...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28557279/development-of-a-novel-hollow-fiber-liquid-phase-microextraction-based-on-oil-in-salt-and-its-comparison-with-a-conventional-method
#15
Miao-Miao Li, Shuang Hu, Xuan Chen, Xiao-Hong Bai
A novel hollow-fiber liquid-phase microextraction based on oil-in-salt was proposed and introduced for the simultaneous extraction and enrichment of the main active compounds of hesperidin, honokiol, shikonin, magnolol, emodin and β,β'-dimethylacrylshikonin in a formula of Zi-Cao-Cheng-Qi Decoction and the single herbs, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Radix et Rhizoma and Lithospermum erythrorhizon, before their analysis by high-performance liquid chromatography. The results obtained by the proposed procedure were compared with those obtained by conventional hollow-fiber liquid-phase microextraction, and the proposed procedure mechanism was described...
May 30, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28554061/comparative-pharmacokinetic-study-of-baicalin-and-its-metabolites-after-oral-administration-of-baicalin-and-chaiqin-qingning-capsule-in-normal-and-febrile-rats
#16
COMPARATIVE STUDY
Xiao-Kui Huo, Bo Wang, Lu Zheng, Hai-Jian Cong, Ting Xiang, Shu-Mei Wang, Cheng-Peng Sun, Chao Wang, Lin Zhang, Sa Deng, Bin Wu, Xiao-Chi Ma
An accurate, precise, selective, and sensitive high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) method was developed for the simultaneous determination of baicalin and its metabolite, baicalein 6-O-glucopyranuronoside, in normal and febrile rats plasma. Two analytes, along with hesperidin as an internal standard, were determined by multiple reactions monitoring (MRM) operated in the positive electrospray ionization (ESI) mode. Chromatographic separation was performed on an Agilent ZORBAX Extend-C18 column (100mm×2...
August 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28551406/protective-effect-of-hesperidin-and-tiger-nut-against-acrylamide-toxicity-in-female-rats
#17
Soha M Hamdy, Amany M Shabaan, Abdel Karim M Abdel Latif, Ayman M Abdel-Aziz, Alshimaa M Amin
Phytochemicals that have antioxidant effect play important role in protection against several diseases in humans. This study was carried out to evaluate the efficacy of hesperidin and tiger nut against the early changes that may be related to the toxicity of acrylamide in female rats. 72 Sprague Dawley female rats were divided into six groups (12 rat/group): control group (I); hesperidin (HES) treated group (II); tiger nut (TN) treated group (III); Acrylamide (ACR) treated group (IV); HES-ACR treated group (V); and TN-ACR treated group (VI)...
May 24, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28539725/inhibition-of-cytochrome-p450-cyp3a4-activity-by-extracts-from-57-plants-used-in-traditional-chinese-medicine-tcm
#18
Mohamed L Ashour, Fadia S Youssef, Haidy A Gad, Michael Wink
BACKGROUND: Herbal medicine is widely used all over the world for treating various health disorders. It is employed either alone or in combination with synthetic drugs or plants to be more effective. OBJECTIVE: The assessment of the effect of both water and methanol extracts of 57 widely used plants from Traditional Chinese Medicine (TCM) against the main phase I metabolizing enzyme CYP3A4 in vitro for the first time. MATERIALS AND METHODS: The inhibition of cytochrome P450 activity was evaluated using a luminescence assay...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28539711/flavonoids-isolated-from-the-flowers-of-limonium-bicolor-and-their-in-vitro-antitumor-evaluation
#19
Jian Chen, Jiehui Teng, Li Ma, Haiying Tong, Bingru Ren, Linshan Wang, Weilin Li
BACKGROUND: Limonium bicolor, a halophytic species, can grow in saline or saline-alkali soil, is well known as a traditional Chinese medicine. Recently it attracted much attention for its treatment for cancer. OBJECTIVE: The present study was performed to evaluate this species from the phytochemical standpoint and the possible relationship between the antitumor activity and its natural products. MATERIALS AND METHODS: The chemical constituents from the flowers of L...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28531921/hesperetin-post-treatment-prevents-rat-cardiomyocytes-from-hypoxia-reoxygenation-injury-in-vitro-via-activating-pi3k-akt-signaling-pathway
#20
Shangfei He, Xianbao Wang, Yongkang Zhong, Lu Tang, Ya Zhang, Yuanna Ling, Zhipeng Tan, Pingzhen Yang, Aihua Chen
Hesperidin (HES), a citrus fruit extract, has beneficial effects on various ischemia/reperfusion (I/R) models. Here, we investigated the possible positive effect of hesperetin (HPT), an active metabolite of HES, and identified the potential molecular mechanisms involved in cardiomyocytes H/R-induced injury. To construct the cardiomyocyte model of hypoxia/reoxygenation (H/R) injury, cultured neonatal rat cardiomyocytes were subjected to 3h of hypoxia followed by 3h of reoxygenation. Cell viability and apoptosis were detected...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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