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hesperidin

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https://www.readbyqxmd.com/read/27912911/hesperidin-ameliorates-immunological-outcome-and-reduces-neuroinflammation-in-the-mouse-model-of-multiple-sclerosis
#1
Dariush Haghmorad, Mohammad Bagher Mahmoudi, Zohreh Salehipour, Zoleikha Jalayer, Amir Abbas Momtazi Brojeni, Maryam Rastin, Parviz Kokhaei, Mahmoud Mahmoudi
Multiple sclerosis (MS) is the most abundant central nervous system (CNS) inflammatory disease, which is due to the reaction of auto reactive T cells with own myelin proteins, leading to physical disorder and paralysis among people suffering the disease. Hesperidin, a flavanone glycoside found abundantly in citrus fruits possesses a wide range of pharmacological properties including potential anti-inflammatory and anti-cancer effects. This study was designed to reveal the molecular and cellular mechanisms underlying the effect of hesperidin on MS alleviation...
November 26, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27871833/oral-hesperidin-amorphization-and-improved-dissolution-properties-by-controlled-loading-onto-porous-silica
#2
Qionghua Wei, Cornelia M Keck, Rainer H Müller
The oral bioavailability of poorly soluble drugs can be improved by amorphization generated by loading into the pores of mesoporous particles (pore size 2-50nm). The main mechanisms are increased kinetic saturation solubility and dissolution velocity due to the amorphous drug state and the nano-size of the drug (=increased dissolution pressure). In this study, the maximum achievable drug loading compared to the theoretical drug loading, and the effect of drug loading degree on the dissolution properties (solubility, dissolution velocity) were investigated...
November 18, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27853724/evaluating-radioprotective-effect-of-hesperidin-on-acute-radiation-damage-in-the-lung-tissue-of-rats
#3
A Rezaeyan, R Fardid, G H Haddadi, M A Takhshid, M Hosseinzadeh, M Najafi, A Salajegheh
BACKGROUND: Oxidative stress plays an important role in the pathogenesis and progression of γ-irradiation-induced cellular damage, Lung is a radiosensitive organ and its damage is a dose-limiting factor in radiotherapy. The administration of dietary antioxidants has been suggested to protect against the succeeding tissue damage. The present study aimed to evaluate the radioprotective efficacy of Hesperidin (HES) against γ-irradiation-induced tissue damage in the lung of male rats. MATERIALS AND METHODS: Thirty two rats were divided into four groups...
September 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27818223/hesperitin-derivative-11-suppress-hepatic-stellate-cell-activation-and-proliferation-by-targeting-pten-akt-pathway
#4
Wan-Xia Li, Xin Chen, Yang Yang, Hui-Min Huang, Hai-di Li, Cheng Huang, Xiao-Ming Meng, Jun Li
Hesperitin derivative (HD-11) is a monomeric compound derived from Hesperidin, which is a naturally occurring flavanone glycoside that exerts extensive clinical effects such as anti-inflammatory, anti-oxidant and anti-angiogenic. However, the role and fundamental mechanism of HD-11 in hepatic fibrosis is still unrevealed. In this study, HD-11 not only alleviates ECM deposition in rats with liver fibrosis, but also reduces the expression of α-SMA and col1a1 in TGF-β1-induced HSC-T6 cells. Moreover, it was demonstrated that HD-11 significantly promoted the expression of PTEN in vivo and in vitro...
November 3, 2016: Toxicology
https://www.readbyqxmd.com/read/27816646/hesperidin-ameliorates-uv-radiation-induced-skin-damage-by-abrogation-of-oxidative-stress-and-inflammatory-in-hacat-cells
#5
Min Li, Xiang-Fei Lin, Jie Lu, Bing-Rong Zhou, Dan Luo
Ultraviolet A (UVA) radiation contributes to skin photoaging. Hesperidin which is a flavanone glycoside found in citrus fruit peels, have been intensively studied for their UVA-protective activity, but its effects and mechanisms on UVA irradiation-induced inflammation and oxidative stress have never been described. Thus, the purpose of this study was to evaluate the effects of hesperidin in skin oxidative stress and inflammation induced by UVA irradiation. In this study, we firstly examined whether hesperidin may exert direct protective effects on the UVA-induced in human keratinocytes (HaCaT) cell injury in vitro...
November 1, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27806651/essential-oil-composition-free-radical-scavenging-activity-and-polyphenolic-content-of-gaillonia-eriantha-jaub-spach-from-iran
#6
Atefeh Bahmanzadegan, Vahid Rowshan, Faraneh Zareiyan, Ahmad Hatami
Gaillonia eriantha is a member of family Paederieae (Rubiaceae). The essential oil of G. eriantha growing wild in south of Iran was obtained by hydrodistillation and analysed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). Antioxidante activity and polyphenolic content were identified by DPPH microplate method and HPLC-DAD, respectively. Twenty-two compounds were identified in the oil. The major volatile compounds were camphor (14.8%), octyl formate (14.7%), 1,8-cineole (10.9%), n-decane (8...
November 3, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27797708/randomized-clinical-trial-on-the-efficacy-of-hesperidin-2s-on-validated-cardiovascular-biomarkers-in-healthy-overweight-individuals
#7
Bouke N Salden, Freddy J Troost, Eric de Groot, Yala R Stevens, Marta Garcés-Rimón, Sam Possemiers, Bjorn Winkens, Ad A Masclee
BACKGROUND: Endothelial dysfunction (ED) is involved in the development of atherosclerosis. Hesperidin, a citrus flavonoid with antioxidant and other biological properties, potentially exerts beneficial effects on endothelial function (EF). OBJECTIVE: We investigated the effect of hesperidin 2S supplementation on EF in overweight individuals. DESIGN: This was a randomized, double-blind, placebo-controlled study in which 68 individuals were randomly assigned to receive hesperidin 2S (450 mg/d) or a placebo for 6 wk...
October 26, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27774648/phytoconstituents-as-pharmacotherapeutics-in-rheumatoid-arthritis-challenges-and-scope-of-nano-submicromedicine-in-its-effective-delivery
#8
Mahfoozur Rahman, Sarwar Beg, Amita Verma, Fahad A Al Abbasi, Firoz Anwar, Sumant Saini, Sohail Akhter, Vikas Kumar
OBJECTIVES: The present review explores the therapeutic application of herbals in rheumatoid arthritis (RA) therapy, and how nano/submicromedicine can be fit in the scope of its therapeutic delivery in RA has been addressed. KEY FINDINGS: Incorporation of bioactive such as polyphenols, thymoquinone, resveratrol, hesperidin, curcumin, celastrol and gambogic acid in a dose-dependent manner showed quite high efficacy for the treatment of RA. It can be attributed to their targeting ability against various inflammatory mediators including nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF-kβ, lipoxygenase (LOXs) and arachidonic acid (AA)...
October 24, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27771138/hesperidin-interaction-to-collagen-detected-by-physico-chemical-techniques
#9
Noriko Hiraishi, Takahiro Maruno, Naoya Tochio, Ryohei Sono, Masayuki Otsuki, Tsutomu Takatsuka, Junji Tagami, Yuji Kobayashi
OBJECTIVE: Dentin collagen can be modified by some plant-derived flavonoids to improve properties of dentin organic matrix. Hesperidin (HPN), a hesperetin-7-O-rutinoside flavonoid, has a potential of dentin modification for being based on evidence that a treatment with HPN may resist collagenase degradation and arrest demineralization of human dentin. In this study, biophysical and molecular-level information on the interaction of HPN and collagen was investigated. METHODS: HPN is extracted from citrus fruits...
October 19, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27752497/protective-effects-of-sweet-orange-unshiu-mikan-and-mini-tomato-juice-powders-on-t-bhp-induced-oxidative-stress-in-hepg2-cells
#10
Susoma Jannat, Md Yousof Ali, Hyeung-Rak Kim, Hyun Ah Jung, Jae Sue Choi
The aim of this study was to investigate the protective effects of juice powders from sweet orange [Citrus sinensis (L.) Osbeck], unshiu mikan (Citrus unshiu Marcow), and mini tomato (Solanum lycopersicum L.), and their major flavonoids, hesperidin, narirutin, and rutin in tert-butyl hydroperoxide (t-BHP)-induced oxidative stress in HepG2 cells. The increased reactive oxygen species and decreased glutathione levels observed in t-BHP-treated HepG2 cells were ameliorated by pretreatment with juice powders, indicating that the hepatoprotective effects of juice powders and their major flavonoids are mediated by induction of cellular defense against oxidative stress...
September 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/27744432/short-term-hesperidin-pretreatment-attenuates-rat-myocardial-ischemia-reperfusion-injury-by-inhibiting-high-mobility-group-box-1-protein-expression-via-the-pi3k-akt-pathway
#11
Xuefei Li, Xiaorong Hu, Jichun Wang, Weipan Xu, Chunfeng Yi, Ruisong Ma, Hong Jiang
BACKGROUND/AIMS: Hesperidin pretreatment has been shown to protect against myocardial ischemia/reperfusion (I/R) injury, but the underlying mechanism is poorly understood. This study aimed to investigate the cardioprotective effects of a 3-day hesperidin pretreatment on I/R injury and to further explore whether its mechanism of action was associated with the inhibition of high mobility group box 1 protein (HMGB1) expression via the PI3K/Akt pathway. METHODS: In a fixed-dose study, hematoxylin and eosin staining and myocardial enzyme measurements were used to determine the optimal dose of hesperidin that elicited the best cardioprotective effects against I/R injury...
October 17, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27729798/identifying-candidate-agents-for-lung-adenocarcinoma-by-walking-the-human-interactome
#12
Yajiao Sun, Ranran Zhang, Zhe Jiang, Rongyao Xia, Jingwen Zhang, Jing Liu, Fuhui Chen
Despite recent advances in therapeutic strategies for lung cancer, mortality is still increasing. Therefore, there is an urgent need to identify effective novel drugs. In the present study, we implement drug repositioning for lung adenocarcinoma (LUAD) by a bioinformatics method followed by experimental validation. We first identified differentially expressed genes between LUAD tissues and nontumor tissues from RNA sequencing data obtained from The Cancer Genome Atlas database. Then, candidate small molecular drugs were ranked according to the effect of their targets on differentially expressed genes of LUAD by a random walk with restart algorithm in protein-protein interaction networks...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27720921/hesperidin-derivative-11-inhibits-fibroblast-like-synoviocytes-proliferation-by-activating-secreted-frizzled-related-protein-2-in-adjuvant-arthritis-rats
#13
Yanhui Liu, Zhenghao Sun, Dandan Xu, Junda Liu, Xiaofeng Li, Xiaoqin Wu, Yilong Zhang, Qianqian Wang, Cheng Huang, Xiaoming Meng, Jun Li
Hesperidin (HDN), a flavanone glycoside derived from the citrus cultivation, has a multitude of pharmacological properties, which include antioxidant, anti-inflammatory, hypolipidaemic and anti-carcinogenic actions, but the underlying mechanisms by which treatment of HDN attenuates Rheumatoid Arthritis (RA) remain elusive. Here we engaged to determine whether Hesperidin derivative-11(HDND-11), a HDN derivative with enhanced water-solubility and bioavailability, is effective on treating arthritis in rats. In this study, results of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetra-zolium bromide (MTT) assay and Flow cytometry indicated that administration of HDND-11 inhibited proliferation of fibroblast-like synoviocytes (FLS)...
October 7, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27720920/antispasmodic-effect-of-selected-citrus-flavonoids-on-rat-isolated-jejunum-specimens
#14
Marta Mendel, Magdalena Chłopecka, Natalia Dziekan, Wojciech Karlik
Citrus flavonoids are acknowledged for numerous pharmacological activities, including the myorelaxant effect on various smooth muscles. However, there is no data on their effect on jejunum contractility. Therefore, the aim of the study at hand was to evaluate the impact of hesperetin and diosmetin along with their glycosides on the motoric activity of intestine and to verify the possible mechanism of hesperetin-induced effect. The experiments were performed on rat isolated jejunum strips and were conducted under isometric conditions...
October 6, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27704466/anti-arthritogenic-and-cardioprotective-action-of-hesperidin-and-daidzein-in-collagen-induced-rheumatoid-arthritis
#15
Shafeeque Ahmad, Khursheed Alam, M Mobarak Hossain, Mahino Fatima, Fakiha Firdaus, Mohammad Faraz Zafeer, Zarina Arif, Murad Ahmed, K A Nafees
Atherosclerosis has been linked to chronic inflammatory processes. Changes in the levels of lipoproteins, especially low-density lipoprotein or its variants, as well as inflammatory markers are risk factors for the atherosclerosis. In the present study, an experimental model of rheumatoid arthritis was developed by administrating collagen suspension intradermally in the tail region of Wistar albino rats. At the same time, a suspension of hesperidin (50 mg/kg body weight) and daidzein (20 mg/kg body weight) was orally administrated...
October 4, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27701140/leaves-of-cordia-boissieri-a-dc-as-a-potential-source-of-bioactive-secondary-metabolites-for-protection-against-metabolic-syndrome-induced-in-rats
#16
Asmaa I Owis, Amira M Abo-Youssef, Ahmed H Osman
Cordia boissieri A. DC. (Boraginaceae) is traditionally used as an herbal remedy for diabetes by Hispanic women in Southwestern USA. A recent investigation showed the significant protective effect of ethyl acetate extract against metabolic syndrome (MS). However, the corresponding active principles responsible for this effect and relations between their structure and biological actions remain unclear. Thus, ethyl acetate extract was subjected to column chromatography, which yielded seven compounds identified on the basis of spectroscopic data as rutin, hesperidin, kaempferol-3-O-β-d-glucopyranoside, rosmarinic acid, β-sitosterol-3-O-β-d-glucopyranoside, quercetin, and kaempferol...
October 4, 2016: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/27695481/protective-effects-of-hesperidin-in-experimental-testicular-ischemia-reperfusion-injury-in-rats
#17
Emrah Celik, Hakan Oguzturk, Nurhan Sahin, Muhammet Gökhan Turtay, Fatih Oguz, Osman Ciftci
INTRODUCTION: In this study, we aimed to determine the protective effects of hesperidin, a citrus flavonoid, in a model of testicular ischemia/reperfusion injury in rats. MATERIAL AND METHODS: Forty-two pubertal male Wistar-Albino rats were divided into six groups: group 1 - control; group 2 - 50 mg/kg hesperidin (low dose hesperidin) used without torsion (LH group); group 3 - 100 mg/kg hesperidin without torsion (HH group); group 4 - torsion/detorsion group (T/D); group 5 - T/D + 50 mg/kg hesperidin treatment group (T/D + LH); and group 6 - T/D + 100 mg/kg hesperidin treatment group (T/D + HH)...
October 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27693952/simultaneous-quantification-and-identification-of-flavonoids-lignans-coumarin-and-amides-in-leaves-of-zanthoxylum-armatum-using-uplc-dad-esi-qtof-ms-ms
#18
Vinod Bhatt, Sushila Sharma, Neeraj Kumar, Upendra Sharma, Bikram Singh
The current study presents isolation and characterization of twelve compounds including catechin (1), isovitexin (2), hesperidin (3), psoralin (4), eudesmin (5), kobusin (6), fargesin (7), sesamin (8), asarinin (9), planispine-A (10), α-sanshool (11) and vitexin (12), from the leaves of Zanthoxylum armatum. Further, two rapid and simple ultra performance liquid chromatography-diode array detection (UPLC-DAD) methods were developed for the simultaneous quantitative determination of isolated compounds from Z...
September 26, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27677544/hesperidin-a-citrus-flavonoid-protects-against-l-methionine-induced-hyperhomocysteinemia-by-abrogation-of-oxidative-stress-endothelial-dysfunction-and-neurotoxicity-in-wistar-rats
#19
B Hemanth Kumar, B Dinesh Kumar, Prakash V Diwan
CONTEXT: Hesperidin (HSP), a flavanoglycone found in citrus fruits, has antioxidant, anti-inflammatory and neuroprotective properties. OBJECTIVE: This study evaluates the protective effect of HSP on l-methionine-induced hyperhomocysteinemia (HHcy) in rats. MATERIALS AND METHODS: Male Wistar rats were randomly divided into seven groups as DMSO, l-methionine, HSP (25, 50 and 100 mg/kg), HSP-per se (100 mg/kg) and donepezil (0.1 mg/kg)...
September 27, 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27672659/antihyperalgesic-effect-of-hesperidin-improves-with-diosmin-in-experimental-neuropathic-pain
#20
Azucena I Carballo-Villalobos, María-Eva González-Trujano, Francisco Pellicer, Francisco J López-Muñoz
Neuropathic pain is caused by a primary lesion, dysfunction, or transitory perturbation in the peripheral or central nervous system. In this study, we investigated the hesperidin antihyperalgesic effects alone or combined with diosmin in a model of neuropathic pain to corroborate a possible synergistic antinociceptive activity. Mechanical and thermal hyperalgesia were assessed in the aesthesiometer and plantar tests, respectively, after chronic constriction injury (CCI) model in rats receiving hesperidin (HS, 5 doses from 10 to 1000 mg/kg) alone or combined with diosmin (DS, 10 and 100 mg/kg) in comparison to gabapentin (31...
2016: BioMed Research International
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