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hesperidin

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https://www.readbyqxmd.com/read/29781423/in-vitro-ovicidal-and-larvicidal-activities-of-some-saponins-and-flavonoids-against-parasitic-nematodes-of-goats
#1
Acidália Carine Vieira Santos, Francianne Oliveira Santos, Hélimar Gonçalves Lima, Gisele Dias Da Silva, Rosangela Soares Uzêda, Êuder Reis Dias, Alexsandro Branco, Klauber Viana Cardoso, Jorge Mauricio David, Mariana Borges Botura, Silvia Lima Costa, Maria José Moreira Batatinha
This study assessed the anthelmintic activity of plant-derived compounds against gastrointestinal nematodes of goats using the egg hatch and larval motility assays. The compounds tested were saponins (digitonin and aescin) and their respective sapogenins (aglycones), hecogenin acetate and flavonoids (catechin, hesperidin, isocordoin and a mixture of isocordoin and cordoin). Additionally, cytotoxicity of active substances was analysed on Vero cell through 3-4,5-dimethylthiazol-2-yl,2,5diphenyltetrazolium bromide (MTT) and propidium iodide (PI) tests...
May 21, 2018: Parasitology
https://www.readbyqxmd.com/read/29772520/-valeriana-wallichii-extract-inhibits-tert-booh-induced-oxidative-damage-and-cytotoxicity
#2
Vishal Jain, Ruma Dutta, Doddamane Thippeswamy Maheshwari, Darmendra Kumar Meena, Kshipra Misra, Mysore Sadashiva Yogendra Kumar
Oxidative s tress is well known to be involved in pathophysiology of several disorders. Valeriana wallichii (VW) root extracts is known for its expedient activities but its antioxidant and cytoprotective efficacy need to be explored further. In present study tertiary-butyl hydroperoxide (tert-BOOH) was used to induce oxidative stress in C6 glioma cells. Antioxidant activity of the VW root extracts were evaluated by chemical assays i.e . DPPH, ABTS and FRAP assay. Further effect of VW on tert-BOOH induced oxidative stress and mitochondrial damage was studied...
June 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/29754503/hesperidin-suppresses-renin-angiotensin-system-mediated-nox2-over-expression-and-sympathoexcitation-in-2k-1c-hypertensive-rats
#3
Chutamas Wunpathe, Prapassorn Potue, Putcharawipa Maneesai, Sarawoot Bunbupha, Parichat Prachaney, Upa Kukongviriyapan, Veerapol Kukongviriyapan, Poungrat Pakdeechote
Hesperidin, a flavonoid derived from citrus fruits, possesses several beneficial effects including anti-oxidation and anti-inflammation. The aim of this study was to investigate the effects of hesperidin on the renin-angiotensin system (RAS) cascade that mediated oxidative stress and sympathoexcitation in two-kidney, one-clipped (2K-1C) hypertensive rats. 2K-1C hypertension was induced in male Sprague-Dawley rats. Hypertensive rats were treated with hesperidin at 20[Formula: see text]mg/kg or 40[Formula: see text]mg/kg or losartan at 10[Formula: see text]mg/kg beginning at three weeks after surgery and then continued for four weeks ([Formula: see text]/group)...
May 13, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29747741/evaluation-of-anti-lipase-activity-and-bioactive-flavonoids-in-the-citri-reticulatae-pericarpium-from-different-harvest-time
#4
Su-Ling Zeng, Shang-Zhen Li, Chang-Jiang-Sheng Lai, Min-Yan Wei, Bai-Zhong Chen, Ping Li, Guo-Dong Zheng, E-Hu Liu
BACKGROUND: Inhibition of pancreatic lipase is an attractive approach to the treatment of obesity and other metabolic disorders. Naturally occurring phytochemicals are promising sources of lipase inhibitors. PURPOSE: In the present study, the anti-lipase activity of Citri Reticulatae Pericarpium (CRP) extracts was firstly evaluated in vitro. Moreover, the dynamic alteration of bioactive flavonoids in CRP collected at different time and its correlation with anti-lipase activities was investigated...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29743461/-determination-of-hesperidin-and-monoglucosylhesperidin-contents-in-processed-foods-using-relative-molar-sensitivity-based-on-1-h-quantitative-nmr
#5
Yuzo Nishizaki, Naoko Sato-Masumoto, Akihito Nakanishi, Yushi Hashizume, Mahamadou Tandia, Taichi Yamazaki, Miho Kuroe, Masahiko Numata, Toshihide Ihara, Naoki Sugimoto, Kyoko Sato
We designed an off-line combination of HPLC/photodiode array detector (PDA) and 1 H-quantitative NMR (1 H-qNMR) to estimate the relative molar sensitivity (RMS) of an analyte to a reference standard. The RMS is calculated as follows: a mixture of the analyte and the reference is analyzed using 1 H-qNMR and HPLC/PDA. The response ratio of the analyte and the reference obtained by HPLC/PDA is then corrected using the molar ratio obtained by 1 H-qNMR. We selected methylparaben (MPB), which is a certified reference material, as the reference standard and hesperidin (Hes) and monoglucosylhesperidin (MGHes) as analytes, and the RMSs of Hes283 nm /MPB255 nm and MGHes283 nm /MPB255 nm were determined as 1...
2018: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/29738867/pharmacoinformatics-approach-for-the-identification-of-polo-like-kinase-1-inhibitors-from-natural-sources-as-anti-cancer-agents
#6
Mohamed F AlAjmi, Md Tabish Rehman, Afzal Hussain, Gulam Mohmad Rather
Polo-like kinase-1 (PLK-1) plays a key role in cell cycle progression during mitosis. Overexpression/dysfunction of PLK-1 is directly associated with cancerous transformation and has been reported in different cancer types. Here, we employed high throughput virtual screening and molecular docking to screen Selleck's natural compound library against PLK-1 kinase domain. We have identified eight bioactive compounds (Apigenin, Dihydromyricetin, Diosmetin, Hesperidin, Hesperitin, Naringenin, Phlorizi, and Quercetin) as the potential inhibitors of PLK-1...
May 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29734842/the-beneficial-effects-of-nerolidol-and-hesperidin-on-surgically-induced-endometriosis-in-a-rat-model
#7
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Aslı Cetin, Nese Basak
The objective of this article is to analyze the effects of nerolidol and hesperidin treatment on surgically induced endometriosis in a rat model. Endometriosis was induced in 24 healthy adult female Wistar albino rats via homologous uterine horn transplantation. Three operations were performed on each rat. After the second operation, the rats were randomized into control, nerolidol, and hesperidin treatment groups, and medications were administered for 2 weeks. The effects of the drugs on the endometriotic foci were evaluated after the third operation...
May 7, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29720826/the-effects-of-hesperidin-and-quercetin-on-serum-tumor-necrosis-factor-alpha-and-interleukin-6-levels-in-streptozotocin-induced-diabetes-model
#8
Eda Dokumacioglu, Hatice Iskender, Tugba Mazlum Sen, Imran Ince, Ali Dokumacioglu, Yalcin Kanbay, Elif Erbas, Sinan Saral
Background: Diabetes mellitus (DM) is a metabolic disorder that occurs as a result of absolute or relative insufficiency of insulin release and/or insulin effect due to impairment of carbohydrate, fat and protein metabolism, and it is characterized by hyperglycemia and leads to various complications. Objective: In this study, it was aimed to investigate the effects of hesperidin (HP) and quercetin , which are natural flavonoids, on serum malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) levels in rats with streptozotocin (STZ)-induced diabetes...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29698773/network-pharmacology-based-prediction-of-active-compounds-and-molecular-targets-in-yijin-tang-acting-on-hyperlipidaemia-and-atherosclerosis
#9
A Yeong Lee, Won Park, Tae-Wook Kang, Min Ho Cha, Jin Mi Chun
ETHNOPHARMACOLOGICAL RELEVANCE: Yijin-Tang (YJT) is a traditional prescription for the treatment of hyperlipidaemia, atherosclerosis and other ailments related to dampness phlegm, a typical pathological symptom of abnormal body fluid metabolism in Traditional Korean Medicine. However, a holistic network pharmacology approach to understanding the therapeutic mechanisms underlying hyperlipidaemia and atherosclerosis has not been pursued. AIM OF THE STUDY: To examine the network pharmacological potential effects of YJT on hyperlipidaemia and atherosclerosis, we analysed components, performed target prediction and network analysis, and investigated interacting pathways using a network pharmacology approach...
July 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29698678/citrus-bioflavonoids-possess-dipeptidyl-peptidase-4-inhibition-activity-similar-to-gliptin-antidiabetic-medication
#10
Ankit Gupta, Glenn A Jacobson, John R Burgess, Herbert F Jelinek, David S Nichols, Christian K Narkowicz, Hayder A Al-Aubaidy
This study demonstrates the Dipeptidyl peprtidase-4 (DPP-4) inhibition activity of citrus bioflavonoid nutraceuticals as compared to known gliptins. Citrus bioflavonoid standards and three commercially available citrus bioflavonoid supplements (Thompson's Super Bioflavonoid Complex® (SB), Ethical Nutrient Citrus Plus Vitamin C® (EN), and Country Life Citrus Bioflavonoid & Rutin® (CB)) were considered in this study. Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) analysis was undertaken to identify the citrus bioflavonoids present in each supplement and the DPP-4 inhibitory activity was determined using the DPP-4 fluorometric assay...
April 23, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29687202/attenuation-of-aluminum-chloride-induced-neuroinflammation-and-caspase-activation-through-the-akt-gsk-3%C3%AE-pathway-by-hesperidin-in-wistar-rats
#11
Arokiasamy Justin-Thenmozhi, Mathiyazahan Dhivya Bharathi, Ramaraj Kiruthika, Thamilarasan Manivasagam, Anupom Borah, Musthafa Mohamed Essa
Hesperidin, a flavanoglycone abundantly present in citrus fruits, is reported to have antioxidant, anti-inflammatory, and neuroprotective properties. Previous reports from our laboratory indicated the neuroprotective effect of hesperidin against aluminum chloride (AlCl3 )-induced memory loss, acetylcholine esterase hyperactivity, oxidative stress, and enhanced expression of amyloid β protein biosynthesis-related markers. However, their role on AlCl3 -induced inflammation, caspase activation, Tau pathology, altered Akt/GSK 3β signaling pathway, and Aβ clearance marker has not yet been fully elucidated...
April 23, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29678627/structural-and-functional-insights-into-rha-p-a-bacterial-gh106-%C3%AE-l-rhamnosidase-from-novosphingobium-sp-pp1y
#12
Francesca Mensitieri, Federica De Lise, Andrea Strazzulli, Marco Moracci, Eugenio Notomista, Valeria Cafaro, Emiliano Bedini, Matthew Howard Sazinsky, Marco Trifuoggi, Alberto Di Donato, Viviana Izzo
α-L-Rhamnosidases (α-RHAs, EC 3.2.1.40) are glycosyl hydrolases (GHs) hydrolyzing terminal α-L-rhamnose residues from different substrates such as heteropolysaccharides, glycosylated proteins and natural flavonoids. Although the possibility to hydrolyze rhamnose from natural flavonoids has boosted the use of these enzymes in several biotechnological applications over the past decades, to date only few bacterial rhamnosidases have been fully characterized and only one crystal structure of a rhamnosidase of the GH106 family has been described...
April 17, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29677538/improvement-effects-of-a-mixed-extract-of-flowers-of-pueraria-thomsonii-benth-and-peels-of-citrus-unshiu-markovich-on-postmenopausal-symptoms-of-ovariectomized-mice
#13
Na-Ra Han, Sun-Young Nam, Sungwei Hong, Hee-Yun Kim, Phil-Dong Moon, Hyeong-Jin Kim, Hosong Cho, Boyoung Lee, Hyung-Min Kim, Hyun-Ja Jeong
BACKGROUND: Menopausal hot flushes occur frequently in postmenopausal women. In the present study, we investigated a regulatory effect of a mixed extract of flowers of Pueraria thomsonii Benth. and peels of Citrus unshiu Markovich (PCE17), an extract of flowers of Pueraria thomsonii Benth. (PE), an extract of peels of Citrus unshiu Markovich (CE), a mixture of tectorigenin 7-O-xylosylglucoside, tectoridin, and tectorigenin (Tec, the active compounds of PE), and hesperidin (Hes, an active compound of CE) on menopausal hot flushes...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29676098/-study-on-influence-of-different-storage-environments-and-packaging-materials-on-quality-of-citri-reticulatae-pericarpium
#14
Jiao-Yang Luo, Wen-Ju Zhou, Kun-Lun Li, Ming Zhao, Mei-Hua Yang
Traditional Chinese herbs are readily contaminated by mold that produced mycotoxins which are closly related to the herbs' external factors and external environments during the storage process. In this study, Citri Reticulatae Pericarpium was used as example, and the characteristics of traits, water content, active components (naringin, hesperidin, sinensetin, naringin, tangeretin) and the accumulation of aflatoxins (AFs) were selected as the evaluation indexes. Citri Reticulatae Pericarpium was stored under different environments and packaging materials for 12 months, and then the quality changes and mildew of Citri Reticulatae Pericarpium were examined...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29672974/inhibition-of-uvb-induced-pro-inflammatory-cytokines-and-mmp-expression-by-zanthoxylum-rhetsa-bark-extract-and-its-active-constituent-hesperidin
#15
Ramesh Kumar Santhanam, Sharida Fakurazi, Syahida Ahmad, Faridah Abas, Intan Safinar Ismail, Yaya Rukayadi, Muhammad Tayyab Akhtar, Khozirah Shaari
The antiphoto aging property of Zanthoxylum rhetsa obtained from Pangkor Island, Malaysia, was evaluated. Solvent fractions of different polarity obtained from the methanolic extract of the bark material were initially tested for anticollagenase and antielastase activities. The ethyl acetate fraction showed bioactivity against the protease enzymes. Hence, it was subjected to further purification via column chromatography, to yield a major constituent, hesperidin. Subsequently, the ethyl acetate fraction and hesperidin were tested for their effects against UVB-induced cytotoxicity and expressions of inflammatory cytokines (IL-6, IL-1β, and TNF-α), NF-κB, and MMPs (MMP1, 3, and 9) in human dermal fibroblasts (HDF)...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29668805/influence-of-hesperidin-and-vitamin-c-on-glycemic-parameters-lipid-profile-and-dna-damage-in-rats-treated-with-sucrose-overload
#16
Silvia I R Franke, Patrícia Molz, Camila Mai, Joel H Ellwanger, Fernanda F Zenkner, Jorge A Horta, Daniel Prá
We evaluated the influence of hesperidin and vitamin C (VitC) on glycemic parameters, lipid profile, and DNA damage in male Wistar rats treated with sucrose overload. Rats were divided into six experimental groups: I-water control; II-sucrose control; III-hesperidin control; IV-VitC control; V-co-treatment of sucrose plus hesperidin; VI-co-treatment of sucrose plus VitC. We measured the levels of triglycerides, total cholesterol, HDL-c, LDL-c, fasting glucose, and glycated hemoglobin (A1C). DNA damage was evaluated in blood and brain cells using the comet assay and the micronucleus test was used to evaluate chromosomal damages in the rat bone marrow...
April 16, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29665555/hesperidin-promotes-programmed-cell-death-by-downregulation-of-nongenomic-estrogen-receptor-signalling-pathway-in-endometrial-cancer-cells
#17
Z B Cincin, B Kiran, Y Baran, B Cakmakoglu
Endometrial carcinoma (EC) is the most common malignant gynecologic tumor in women. EC is thought to be caused by increasing estrogen levels relative to progesterone in the body. Hesperidin (Hsd), a biologically active flavonoid, could be extracted from Citrus species. It has been recently shown that Hsd could exert anticarcinogenic properties in different cancer types. However, the effects of Hsd and its molecular mechanisms on EC remain unclear. In this study, the antiproliferative, apoptotic and genomic effects of Hsd in EC and its underlying mechanisms were identified...
April 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29653456/hesperidin-prevents-high-glucose-induced-damage-of-retinal-pigment-epithelial-cells
#18
Wayne Young Liu, Shorong-Shii Liou, Tang-Yao Hong, I-Min Liu
The present study aimed to determine whether hesperidin, a plant-based active flavanone found in citrus fruits, can prevent high glucose-induced retinal pigment epithelial (RPE) cell impairment. Cultured human RPE cells (ARPE-19) were exposed to a normal glucose concentration (5.5 mM) for 4 d and then soaked in either normal (5.5 mM) or high (33.3 mM) concentrations of D-glucose with or without different concentrations of hesperidin (10, 20, or 40 µM) for another 48 h. The survival rates of the cells were measured using a 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide reduction assay...
April 13, 2018: Planta Medica
https://www.readbyqxmd.com/read/29628656/comparative-evaluation-of-the-effect-of-10-sodium-ascorbate-10-hesperidin-1-riboflavin-5-phosphate-collagen-cross-linkers-on-the-pushout-bond-strength-of-fiber-postluted-to-radicular-dentin-in-vitro-study
#19
Kosha Jain, Lotika Beri, Kunal Kunjir, Nikhil Borse, Neha Neekhara, Aishwarya Kadam
Aims: The aim of the study was to evaluate the effect of 10% sodium ascorbate (SA),10% hesperidin, 1% riboflavin 5-phosphate, collagen cross-linkers, on the pushout bond strength of the fiber resin postluted to the radicular dentin. Materials and Methods: Twenty-eight, single-rooted extracted human teeth were collected. The cleaning shaping and obturation was done followed postspace preparation which was etched with 37% phosphoric acid for 15 s and then rinsed with normal saline...
January 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29628291/citri-reticulatae-pericarpium-chenpi-botany-ethnopharmacology-phytochemistry-and-pharmacology-of-a-frequently-used-traditional-chinese-medicine
#20
REVIEW
Xin Yu, Shuang Sun, Yuyan Guo, Yan Liu, Dayu Yang, Guoyu Li, Shaowa Lü
ETHNOPHARMACOLOGICAL RELEVANCE: Citri Reticulatae Pericarpium (Rutaceae, CRP), commonly called as Chenpi () in Chinese, is most frequently used as a qi-regulating drug in thousands of Chinese medicine prescriptions. CRP is found mainly in major citrus-producing areas such as the Guangdong, Guangxi, Sichuan, Fujian, and Zhejiang Provinces of China. Since thousands of years in China, CRP has been used widely in clinical practice to treat nausea, vomiting, indigestion, anepithymia, diarrhea, cough, expectoration, and so on...
April 5, 2018: Journal of Ethnopharmacology
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