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hesperidin

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https://www.readbyqxmd.com/read/28416860/characterization-of-phenolic-profile-and-antioxidant-capacity-of-different-fruit-part-from-lemon-citrus-limon-burm-cultivars
#1
Wanpeng Xi, Juanfang Lu, Junping Qun, Bining Jiao
Phenolic composition and antioxidant capacity of different fruit part including peel, pulp, juice, whole fruit and seed from five lemon cultivars (Feiminailao, Cuningmeng Limeng, Pangdelusaningmeng, Beijingningmeng) were investigated. Caffeic acid (9.31-741.4 μg/g FW) and chlorogenic acid (2.7-527.5 μg/g FW) were the dominant phenolic acid in fruit tested, Pangdelusaningmeng (PD) and Limeng peels with the highest contents, respectively. Hesperidin was the predominant flavanone (10.27-3315 μg/g FW), Cuningmeng (CN) peels with the highest level...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28407962/evaluation-of-bioactive-flavonoids-and-antioxidant-activity-in-pericarpium-citri-reticulatae-citrus-reticulata-chachi-during-storage
#2
Manqin Fu, Yujuan Xu, Yulong Chen, Jijun Wu, Yuanshan Yu, Bo Zou, Kejing An, Gengsheng Xiao
A simple and accurate method using high performance liquid chromatography (HPLC) with dual wavelength detection was developed to simultaneously determine the contents of one flavanone glycoside (hesperidin) and five polymethoxylated flavones (PMFs: sinensetin, 4',5,7,8-tetramethoxyflavone, nobiletin, tangeretin and 5-O-desmethyl nobiletin) in Pericarpium Citri Reticulatae (Citrus reticulata 'Chachi') ('Chachi' PCR). By modifying the mobile phase compositions and detection wavelengths, an optimal HPLC condition was obtained, under which the calibration curves of all six compounds exhibited good linearity (R(2)>0...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28405105/hesperidin-as-radioprotector-against-radiation-induced-lung-damage-in-rat-a-histopathological-study
#3
Gholam Hassan Haddadi, Abolhasan Rezaeyan, Mohammad Amin Mosleh-Shirazi, Massood Hosseinzadeh, Reza Fardid, Masoud Najafi, Ashkan Salajegheh
Reactive oxygen species (ROS) are generated by ionizing radiation, and one of the organs commonly affected by ROS is the lung. Radiation-induced lung injury including pneumonia and lung fibrosis is a dose-limiting factor in radiotherapy (RT) of patients with thorax irradiation. Administration of antioxidants has been proved to protect against ROS. The present study was aimed to assess the protective effect of hesperidin (HES) against radiation-induced lung injury of male rats. Fifty rats were divided into three groups...
January 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28395272/the-effect-of-hesperidin-and-quercetin-on-oxidative-stress-nf-%C3%AE%C2%BAb-and-sirt1-levels-in-a-stz-induced-experimental-diabetes-model
#4
Hatice Iskender, Eda Dokumacioglu, Tugba Mazlum Sen, Imran Ince, Yalcin Kanbay, Sinan Saral
OBJECTIVE: The aim of this study is to investigate the roles of SIRT1 and NF-κB in the pathogenesis of diabetes mellitus in rats with STZ-induced diabetes and determine the effects of hesperidin and quercetin on oxidative stress and on the levels of SIRT1 and NF-κB. MATERIALS AND METHODS: The experimental animals were divided into four groups, each group comprising ten rats designated as follows: group 1 served as control rats (C); group 2 served as diabetic rats (DM); group 3 served as diabetic rats administered hesperidin (DM+HSP) (100mg/kg b...
April 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28390858/combining-in%C3%A2-vitro-in%C3%A2-vivo-and-in-silico-approaches-to-evaluate-nutraceutical-potentials-and-chemical-fingerprints-of-moltkia-aurea-and-moltkia-coerulea
#5
Gokhan Zengin, Ramazan Ceylan, Jelena Katanić, Adriano Mollica, Abdurrahman Aktumsek, Tatjana Boroja, Sanja Matić, Vladimir Mihailović, Snežana Stanić, Zaahira Aumeeruddy-Elalfi, Mustafa Abdullah Yilmaz, Mohamad Fawzi Mahomoodally
Methanolic extracts of Moltkia aurea Boiss. (MA) and Moltkia coerulea (Willd.) Lehm. (MC) were investigated for their antioxidant capacity and enzymatic inhibitory potential against acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, and tyrosinase in vitro. MA and MC were also explored for their antimicrobial effect, as well as for their possible genotoxic/antigenotoxic potential on Drosophila melanogaster in vivo. The total bioactive components (phenolic (TPC) and flavonoid contents (TFC)) were determined and liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolite profiling of MA and MC appraised...
April 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28385612/inhibition-of-liver-alanine-aminotransferase-and-aspartate-aminotransferase-by-hesperidin-and-its-aglycone-hesperetin-an-in-vitro-and-in-silico-study
#6
Sara Zareei, Massoud M A Boojar, Massoud Amanlou
AIMS: This study aimed to investigate the inhibitory effects of two natural flavonoids, hesperetin (HT) and hesperidin (HD), on two gluconeogenesis enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and their possible mechanisms of action. MAIN METHODS: Rat liver incubated with different concentrations of HT and HD was used to measure enzyme activities spectrophotometrically, based on monitoring the oxidation of NADH to NAD(+) at 340nm...
April 3, 2017: Life Sciences
https://www.readbyqxmd.com/read/28366850/antioxidant-and-ion-induced-gelation-functions-of-pectins-enabled-by-polyphenol-conjugation
#7
Soohwan Ahn, Kantappa Halake, Jonghwi Lee
The development of antioxidant polymers through the chemical conjugation of natural polyphenols onto polysaccharides has important applications in biomedical, pharmaceutical, food, and cosmetic fields. Due to their labile characteristics, the covalent conjugation of polyphenols while retaining antioxidant properties has been a challenging task. Herein, four structurally different polyphenols, three with and one without a catechol group, were conjugated onto pectin macromolecules via a simple and efficient preparation method involving epichlorohydrin chemistry...
March 31, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28365326/inhibitory-effects-of-flavonoids-on-biofilm-formation-by-staphylococcus-aureus-that-overexpresses-efflux-protein-genes
#8
Laênia Angélica Andrade Lopes, Jéssica Bezerra Dos Santos Rodrigues, Marciane Magnani, Evandro Leite de Souza, José P de Siqueira-Júnior
This study evaluated the efficacy of glycone (myricitrin, hesperidin and phloridzin) and aglycone flavonoids (myricetin, hesperetin and phloretin) in inhibiting biofilm formation by Staphylococcus aureus RN4220 and S. aureus SA1199B that overexpress the msrA and norA efflux protein genes, respectively. The minimum inhibitory concentration (MIC) and minimum biofilm inhibitory concentration (MBIC50 - defined as the lowest concentration that resulted in ≥50% inhibition of biofilm formation) of flavonoids were determined using microdilution in broth procedures...
March 29, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28340781/use-of-multiresponse-statistical-techniques-to-optimize-the-separation-of-diosmin-hesperidin-diosmetin-and-hesperitin-in-different-pharmaceutical-preparations-by-high-performance-liquid-chromatography-with-uv-dad
#9
Mohamad Subhi Sammani, Sabrina Clavijo, Lindomar Portugal, Ruth Suárez, Hassan Seddik, Víctor Cerdà
A new method for the separation and determination of four flavonoids: hesperidin (HES), diosmin (DIO), hesperitin (HTIN), and diosmetin (DTIN) in pure form and pharmaceutical formulations has been developed by using high performance liquid chromatography (HPLC) with UV-DAD detection. Multivariate statistics (2(k) full factorial and Box Behnken Designs) has been used for the multiresponse optimization of the chromatographic separation, which was completed in 22min, and carried out on a symmetry® C18 column (250×3mm; 5µm) as stationary phase...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28320086/antifibrotic-effect-of-diethylcarbamazine-combined-with-hesperidin-against-ethanol-induced-liver-fibrosis-in-rats
#10
Alaa El-Din El-Sayed El-Sisi, Samia Salim Sokar, Abdelhadi Mohamed Shebl, Dina Zakaria Mohamed
Chronic alcohol consumption leads to extracellular matrix hyperplasia and liver fibrosis with a great role of hepatic stellate cell (HSC) activation in this process. The present study was designed to investigate the possible protective effects of diethylcarbamazine (DEC) (50mg/kg, acting as an anti-inflammatory drug, interferes with the arachidonic acid metabolism) when administrated in combination with hesperidin (HDN) (200mg/kg, a flavanone glycoside with potent antioxidant and anti-inflammatory activities) against alcoholic liver fibrosis in wistar rats compared to silymarin (Sil) (100mg/kg)...
March 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28314477/extraction-of-nobiletin-from-citrus-unshiu-peels-by-supercritical-fluid-and-its-cre-mediated-transcriptional-activity
#11
Chisato Oba, Masaki Ota, Koichiro Nomura, Hironori Fujiwara, Jiro Takito, Yoshiyuki Sato, Yasushi Ohizumi, Hiroshi Inomata
BACKGROUND: Polymethoxyflavone (PMF) is one of bioactive compounds in Citrus Unshiu and included mainly in the peels rather than the fruits, seeds and leaves. HYPOTHESIS/PURPOSE: Supercritical CO2 extraction is one candidate for selective extraction of polymethoxyflavone and in this study, supercritical CO2 extraction with/without ethanol entrainer from Citrus Unshiu peels was examined at a temperature of 333K and a pressure of 30MPa. METHODS: CRE (cyclic AMP response element)-mediated transcriptional assay was examined by using the extracts from supercritical fluid extraction...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28293083/pharmacokinetics-and-pharmacodynamics-of-da-cheng-qi-decoction-in-the-liver-of-rats-with-severe-acute-pancreatitis
#12
Yu-Mei Zhang, Hong-Yu Ren, Xian-Lin Zhao, Juan Li, Jun-Yi Li, Fu-Sheng Wu, Hang Su, Wen-Fu Tang
AIM: To explore the pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction (DCQD) in the liver of rats with severe acute pancreatitis (SAP) based on an herbal recipe tissue pharmacology hypothesis. METHODS: Healthy male Sprague-Dawley rats were randomly divided into a sham operation group (SOG); a model group (MG); and low-, median- and high-dose treatment groups (LDG, MDG, and HDG, respectively). Different dosages (6, 12 and 24 g/kg for the LDG, MDG, and HDG, respectively) of DCQD were administered to the rats with SAP...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28285516/investigation-on-key-molecules-of-huanglongbing-hlb-induced-orange-juice-off-flavor
#13
Johannes Kiefl, Birgit Kohlenberg, Anja Hartmann, Katja Obst, Susanne Paetz, Gerhard Krammer, Stephan Trautzsch
Orange fruits from huanglongbing (HLB)-infected trees do not fully mature and show a severe off-flavor described as bitter-harsh, metallic, and less juicy and fruity. The investigation of juice from HLB-infected (HLBOJ) and healthy control oranges (COJ) by gas chromatography-mass spectrometry showed higher concentrations of fruity esters, such as ethyl butyrate and ethyl 2-methylbutyrate, and soapy-waxy alkanals, such as octanal and decanal, in the COJ, whereas the HLBOJ showed higher concentrations of green aldehydes such as hexanal and degradation compounds of limonene and linalool such as α-terpineol...
March 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28282882/maternal%C3%A2-consumption%C3%A2-of%C3%A2-hesperidin%C3%A2-and%C3%A2-naringin%C3%A2-flavanones%C3%A2-exerts%C3%A2-transient%C3%A2-effects%C3%A2-to%C3%A2-tibia%C3%A2-bone%C3%A2-structure%C3%A2-in%C3%A2-female%C3%A2-cd-1%C3%A2-offspring
#14
Sandra M Sacco, Caitlin Saint, Paul J LeBlanc, Wendy E Ward
Hesperidin (HSP) and naringin (NAR), flavanones rich in citrus fruits, support skeletal integrity in adult and aging rodent models. This study determined whether maternal consumption of HSP and NAR favorably programs bone development, resulting in higher bone mineral density (BMD) and greater structure and biomechanical strength (i.e., peak load) in female offspring. Female CD-1 mice were fed a control diet or a HSP + NAR diet five weeks before pregnancy and throughout pregnancy and lactation. At weaning, female offspring were fed a control diet until six months of age...
March 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28270768/extracts-of-immature-orange-aurantii-fructus-immaturus-and-citrus-unshiu-peel-citri-unshiu-pericarpium-induce-p-glycoprotein-and-cytochrome-p450-3a4-expression-via-upregulation-of-pregnane-x-receptor
#15
Naoto Okada, Aki Murakami, Shiori Urushizaki, Misa Matsuda, Kazuyoshi Kawazoe, Keisuke Ishizawa
P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) are expressed in the intestine and are associated with drug absorption and metabolism. Pregnane X receptor (PXR) is the key molecule that regulates the expression of P-gp and CYP3A4. Given that PXR activity is regulated by a variety of compounds, it is possible that unknown PXR activators exist among known medicines. Kampo is a Japanese traditional medicine composed of various natural compounds. In particular, immature orange [Aurantii fructus immaturus (IO)] and citrus unshiu peel [Citri unshiu pericarpium (CP)] are common ingredients of kampo...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28265836/pro-inflammatory-cytokines-involvement-in-the-hesperidin-antihyperalgesic-effects-at-peripheral-and-central-levels-in-a-neuropathic-pain-model
#16
A I Carballo-Villalobos, M E González-Trujano, N Alvarado-Vázquez, F J López-Muñoz
Emerging evidence proposes a link between immune changes and pain, which is consistent with the inflammation theory and the increased incidence of neurodegenerative diseases. Flavonoids have long been used because of their anti-inflammatory potential activity and they are considered a promising alternative to alleviate neuropathic pain. The aim of this study was to investigate the antihyperalgesic effect of hesperidin and the presence of pro-inflammatory cytokines evaluated at peripheral and central levels in the chronic constriction injury as model of neuropathic pain in rats...
March 6, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28265554/protective-role-of-hesperidin-against-%C3%AE-radiation-induced-oxidative-stress-and-apoptosis-in-rat-testis
#17
Nadia Z Shaban, Ahmed M Ahmed Zahran, Fatma H El-Rashidy, Ahmad S Abdo Kodous
BACKGROUND: Gamma (γ) ray, an electromagnetic radiation, is occasionally accompanying the emission of an alpha or beta particle. Exposure to such radiation can cause cellular changes such as mutations, chromosome aberration and cellular damage which depend upon the total amount of energy, duration of exposure and the dose. Ionizing radiation can impair spermatogenesis and can cause mutations in germ cells. In general, type B spermatogonia are sensitive to this type of radiation. The current study was carried out to evaluate the protective role of hesperidin (H), as a polyphenolic compound, on rat testis injury induced by γ-radiation...
December 2017: Journal of Biological Research
https://www.readbyqxmd.com/read/28262989/dietary-effects-of-soy-and-citrus-flavonoid-on-antioxidation-and-microbial-quality-of-meat-in-broilers
#18
A A Kamboh, A M Memon, M J Mughal, J Memon, M Bakhetgul
The current study investigated dietary effects of soy genistein (SG) and citrus hesperidin (CH) on microbial spoilage and antioxidant quality of chicken meat. Broilers were divided to six treatment groups: control (C), SG and CH, supplemented with 5 mg of SG and 20 mg of CH per kg of feed, respectively, and SGCH1, SGCH2 and SGCH3, supplemented with 5, 10 or 20 mg of SG + CH (1:4) per kg of feed respectively. Both SG and CH reduced (p < .01) the microbial load of spoilage organisms in breast meat at 0 and 15 days of refrigeration...
March 6, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28243886/preparation-nanocrystals-of-poorly-soluble-plant-compounds-using-an-ultra-small-scale-approach
#19
Tao Liu, Guili Yao, Xiaotian Liu, Haipeng Yin
The usage of downscaling technology for producing nanosuspensions/nanocrystals can be beneficial for formulation development, which has attracted increased attention recently. An ultra-small bead milling method (5 mg compound per batch, smallest scale to date) was tested to produce nanocrystals of four poorly soluble plant compounds, i.e., quercetin, rutin, resveratrol, and hesperidin. A particle size of ranged from 200 to 500 nm was obtained for nanosuspensions of four compounds and the stabilizer selection could be achieved within 2 h by using this ultra-small bead milling method...
February 27, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28242952/polyphenolic-content-and-bactericidal-effect-of-mexican-citrus-limetta-and-citrus-reticulata
#20
Andrés Alejandro Damián-Reyna, Juan Carlos González-Hernández, Rafael Maya-Yescas, Consuelo de Jesús Cortés-Penagos, Ma Del Carmen Chávez-Parga
In this study, total phenolics, total flavonoids, hesperidin and ascorbic acid contents in bagasse, juice and seed of mexican sweet lime (Citrus limetta) and mandarine (Citrus reticulata) were determined at two commercial maturity stages (maturation index), as well as their bactericidal effect on Escherichia coli and Staphylococcus aureus. The results showed that bagasses had the highest total phenolics, total flavonoids, and hesperidin content for both, C. limetta, and C. reticulata; highest ascorbic acid contents were found in C...
February 2017: Journal of Food Science and Technology
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