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https://www.readbyqxmd.com/read/29040331/primary-care-models-for-treating-opioid-use-disorders-what-actually-works-a-systematic-review
#1
Pooja Lagisetty, Katarzyna Klasa, Christopher Bush, Michele Heisler, Vineet Chopra, Amy Bohnert
BACKGROUND: Primary care-based models for Medication-Assisted Treatment (MAT) have been shown to reduce mortality for Opioid Use Disorder (OUD) and have equivalent efficacy to MAT in specialty substance treatment facilities. OBJECTIVE: The objective of this study is to systematically analyze current evidence-based, primary care OUD MAT interventions and identify program structures and processes associated with improved patient outcomes in order to guide future policy and implementation in primary care settings...
2017: PloS One
https://www.readbyqxmd.com/read/29035705/linking-patients-with-buprenorphine-treatment-in-primary-care-predictors-of-engagement
#2
Claire B Simon, Judith I Tsui, Joseph O Merrill, Addy Adwell, Elsa Tamru, Jared W Klein
BACKGROUND: Office-based buprenorphine treatment promises to expand effective treatment for opioid use disorder. Unfortunately, patients may be lost during engagement, before induction with medication. Few data are available regarding rates and predictors of successfully reaching induction. METHODS: The sample included 100 consecutive patients seeking treatment in 2016 at an office-based buprenorphine treatment program in an urban, academic primary care clinic. Patients completed phone intake, nurse visit and physician visit prior to induction...
October 10, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29035158/humanizing-folk-devils-using-ethnography
#3
Peter L Myers
The sociological concepts of the "moral panic" and the deviant "folk devil" apply to the drug panics in the United States over methamphetamine, heroin, and crack cocaine. Mothers or pregnant women who smoke crack cocaine, and their babies, are assigned exaggerated "demonic" attributes that result in stigma and societal rejection. Otherwise, ethnographic studies of drug users demonstrate realities that are other than what might be considered were one to merely look at their use and the consequences. These considerations are examined with respect to the image of folk devils, methadone program attendees, smokers of "blunts," opium den habitués, and others grouped together as negative influences as a result of their drug habits...
October 16, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/29033245/clinical-comparison-of-alfaxalone-ketamine-and-propofol-following-medetomidine-and-methadone-in-dogs
#4
Kate L White, David Yates
OBJECTIVE: To compare the clinical effects of alfaxalone, ketamine and propofol in dogs following premedication with medetomidine and methadone. STUDY DESIGN: Prospective, 'blinded' and randomized clinical study. ANIMALS: A total of 75 male dogs presented for neutering at a charity clinic. METHODS: Dogs were allocated to be administered alfaxalone, ketamine or propofol following premedication with medetomidine (20 μg kg(-1)) and methadone (0...
March 6, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29026502/sexual-risk-behaviors-and-condom-use-barriers-in-iranian-men-with-substance-use-disorders
#5
Effat Sadat Merghati-Khoei, Zahed Rezaei, Davood Shojaei-Zadeh, Nammam Ali Azadi, Shahnaz Rimaz, Alireza Bayat, Saeedeh Moayedi-Nia, Sanaz Omati, Farahnaz Salimi, Jeffrey Korte, Therese Killeen, Minoo Mohraz
BACKGROUND: We aimed to investigate risky sexual behaviors (RSBs) and condom use barriers in Iranian men with substance use disorders (SUDs). METHODS: Of the total 1800 outpatient drug free (ODF) and methadone maintenance treatment program (MMTP) active centers in Tehran, Iran, six were selected to participate in the current study. Data were collected (n = 300 men) using three questionnaires including a demographic questionnaire, the Risky Sexual Behavior Questionnaire (RSBQ), and the Condom Barriers Scale (CBS)...
January 2017: Addiction & Health
https://www.readbyqxmd.com/read/29026497/methadone-replacement-therapy-and-sexual-disorders-among-opium-dependent-iranian-men-a-meta-analysis-study
#6
Masoudeh Babakhanian, Ali Akbar Haghdoost, Mahdi Afshari, Fatemeh Taghizadeh, Mahmood Moosazadeh
BACKGROUND: Evaluation of sexual disorders among persons receiving methadone replacement therapy is of great importance, because these problems may lead to non-compliance and relapse. This study aimed to estimate the effect of methadone maintenance therapy (MMT) on sexual function among addicted Iranian men using met-analysis. METHODS: Investigating the available data banks, relevant studies were identified. After exclusion of duplicates, irrelevant papers and low quality articles, eligible papers were entered into the meta-analysis...
January 2017: Addiction & Health
https://www.readbyqxmd.com/read/29021121/effect-of-computerized-cognitive-behavioral-therapy-on-acquisition-of-coping-skills-among-cocaine-dependent-individuals-enrolled-in-methadone-maintenance
#7
Brian D Kiluk, Elise E DeVito, Matthew B Buck, Karen Hunkele, Charla Nich, Kathleen M Carroll
The acquisition of coping skills has long been considered one of the putative mechanisms of cognitive behavioral therapy (CBT) for substance use disorders, yet consistent statistical support is lacking. This study sought to replicate and extend prior findings regarding the quality of coping skills as a mediator of abstinence outcomes from a computerized CBT program for substance users. Participants were methadone-maintained, cocaine dependent individuals enrolled in a clinical trial evaluating the efficacy of computer-based training for CBT ('CBT4CBT') as an add-on to treatment as usual (TAU+CBT4CBT) compared to TAU only...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29021106/use-of-on-site-detoxification-services-co-located-with-a-supervised-injection-facility
#8
Andrew Gaddis, Mary Clare Kennedy, Ekaterina Nosova, M-J Milloy, Kanna Hayashi, Evan Wood, Thomas Kerr
OBJECTIVES: Supervised injection facilities (SIFs) are increasingly being implemented worldwide in response to the harms associated with injection drug use. Although SIFs have been shown to promote engagement of people who use injection drugs (PWID) with external health services, little is known about the potential of co-locating on-site detoxification services with SIFs. The aim of this study was to characterize use of detoxification services co-located at Insite, North America's first SIF, among PWID in Vancouver, Canada...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29019813/contemporary-policies-regarding-alcohol-and-marijuana-use-among-liver-transplant-programs-in-the-united-states
#9
Jiaming Zhu, Ping-Yu Chen, Marla Frankel, Robert R Selby, Tse-Ling Fong
BACKGROUND: Alcoholic liver disease is a common indication for liver transplantation (OLT). Although OLT has been shown to confer survival benefit to patients with acute alcoholic hepatitis (AAH), historically most programs require a 6-month abstinence period prior to OLT which excludes patients with AAH. Marijuana has become legal in more than half the states in the United States. This survey of liver transplant programs was conducted to evaluate current policies regarding alcohol, marijuana and methadone use...
October 10, 2017: Transplantation
https://www.readbyqxmd.com/read/29016868/efficacy-and-safety-of-lubiprostone-in-patients-with-opioid-induced-constipation-phase-3-study-results-and-pooled-analysis-of-the-effect-of-concomitant-methadone-use-on-clinical-outcomes
#10
Egilius L H Spierings, Douglas A Drossman, Byron Cryer, M Mazen Jamal, Taryn Losch-Beridon, Shadreck M Mareya, Martin Wang
Objective: The efficacy and safety of oral lubiprostone for relieving symptoms of opioid-induced constipation (OIC) in patients with chronic noncancer pain were evaluated in a randomized, double-blind, placebo-controlled study. These data were also pooled with those from two similar phase 3 studies to explore the effects of methadone on treatment response. Methods: In the primary study, adults with OIC (fewer than three spontaneous bowel movements [SBMs] per week) were randomized to receive lubiprostone 24 mcg or placebo twice daily for 12 weeks...
July 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28994902/corrected-qt-interval-and-methadone-dose-and-concentrations-in-pregnant-and-postpartum-women
#11
Debra L Bogen, Barbara H Hanusa, James M Perel, Frederick Sherman, Marla A Mendelson, Katherine L Wisner
BACKGROUND: Methadone is a standard treatment for opioid dependence in pregnancy; however, its impact on maternal corrected QT interval (QTc) has not been evaluated. We studied the association between methadone dose and enantiomer-specific plasma concentrations and QTc among pregnant and postpartum women and newborns. We assessed the relevance of QTc screening guidelines for pregnant women and infants. METHODS: From 2006 to 2008, plasma methadone concentrations were measured during pregnancy, postpartum, and in cord blood in women treated for opioid dependence at a single treatment program...
September 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28992662/sample-preparation-method-for-the-combined-extraction-of-ethyl-glucuronide-and-drugs-of-abuse-in-hair
#12
Ulf Christian Juhl Meier, Thomas Briellmann, Eva Scheurer, Franz Dussy
In hair analysis often little hair sample is available while the analysis of a multitude of structurally diverse substances with different concentration ranges is demanded. Often, the analysis of the different substances requires different sample preparation methods, increasing the amount of required hair sample. When segmental hair analysis is necessary, the amount of needed hair sample is further increased. Therefore, the required sample amount for a full analysis can quickly exceed the available hair sample...
October 9, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28988103/opioid-tapering-in-patients-with-prescription-opioid-use-disorder-a-retrospective-study
#13
Kehua Zhou, Peng Jia, Swati Bhargava, Yong Zhang, Taslima Reza, Yuan Bo Peng, Gary G Wang
BACKGROUND AND AIMS: Opioid use disorder (OUD) refers to a maladaptive pattern of opioid use leading to clinically significant impairment or distress. OUD causes, and vice versa, misuses and abuse of opioid medications. Clinicians face daily challenges to treat patients with prescription opioid use disorder. An evidence-based management for people who are already addicted to opioids has been identified as the national priority in the US; however, options are limited in clinical practices...
October 4, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28987068/associations-between-methadone-maintenance-treatment-and-crime-a-17-year-longitudinal-cohort-study-of-canadian-provincial-offenders
#14
Angela Russolillo, Akm Moniruzzaman, Lawrence C McCandless, Michelle Patterson, Julian M Somers
AIMS: To estimate and test the difference in rates of violent and non-violent crime during medicated and non-medicated methadone treatment episodes. DESIGN, SETTING AND PARTICIPANTS: The study involved linkage of population level administrative data (health and justice) for all individuals (n=14,530) in British Columbia, Canada with a history of conviction and who filled a methadone prescription between January 1, 1998 and March 31, 2015. Methadone maintenance treatment was the primary independent variable and was treated as a time-varying exposure...
October 7, 2017: Addiction
https://www.readbyqxmd.com/read/28976288/the-%C3%AE-opioid-receptor-nonsynonymous-variant-118a-g-is-associated-with-prolonged-abstinence-from-heroin-without-agonist-treatment
#15
Orna Levran, Einat Peles, Matthew Randesi, Joel Correa da Rosa, Miriam Adelson, Mary Jeanne Kreek
AIM: This study assesses whether opioid-related gene variants contribute to reduced vulnerability to relapse to heroin in persons who are not treated with μ-opioid receptor agonist. METHODS: Genotypes of 71 SNPs, in nine genes, were analyzed for association with long-term abstinence in former heroin-dependents of European/Middle Eastern ancestry, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 922). RESULTS: The functional OPRM1 nonsynonymous SNP rs1799971 (118A>G) showed significant association with long-term abstinence (Ppermutation  = 0...
October 4, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28965857/modeling-prenatal-opioid-exposure-in-animals-current-findings-and-future-directions
#16
REVIEW
Elizabeth M Byrnes, Fair M Vassoler
The past decade has seen a drastic rise in the number of infants exposed to opioids in utero. It is unclear what lasting effect this exposure may have on these children. Animal models of prenatal opioid exposure may provide insight into potential areas of vulnerability. The present review summarizes the findings across animal models of prenatal opioid exposure, including exposure to morphine, methadone, buprenorphine, and oxycodone. Details regarding the drug, doses, and duration of treatment, as well as key findings, are summarized in tables with associated references...
September 28, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28962652/perceived-benefits-of-the-hepatitis-c-peer-educators-a-qualitative-investigation
#17
A W Batchelder, L Cockerham-Colas, D Peyser, S P Reynoso, I Soloway, A H Litwin
BACKGROUND: Although opioid-dependent patients are disproportionately impacted by hepatitis C (HCV), many do not receive treatment. In addition to HCV treatment-access barriers, substance-using patients may be reluctant to pursue treatment because of wariness of the medical system, lack of knowledge, or stigma related to HCV treatment. Implementation of a formal peer education program is one model of reducing provider- and patient-level barriers to HCV treatment, by enhancing mutual trust and reducing stigma...
September 29, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28962612/spatial-distribution-of-hiv-hcv-and-co-infections-among-drug-users-in-the-southwestern-border-areas-of-china-2004-2014-a-cohort-study-of-a-national-methadone-maintenance-treatment-program
#18
Mingli Li, Rongjian Li, Zhiyong Shen, Chunying Li, Nengxiu Liang, Zhenren Peng, Wenbo Huang, Chongwei He, Feng Zhong, Xianyan Tang, Guanghua Lan
BACKGROUND: A methadone maintenance treatment (MMT) program to curb the dual epidemics of HIV/AIDS and drug use has been administered by China since 2004. Little is known regarding the geographic heterogeneity of HIV and hepatitis C virus (HCV) infections among MMT clients in the resource-constrained context of Chinese provinces, such as Guangxi. This study aimed to characterize the geographic distribution patterns and co-clustered epidemic factors of HIV, HCV and co-infections at the county level among drug users receiving MMT in Guangxi Zhuang Autonomous Region, located in the southwestern border area of China...
September 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28961545/when-does-methadone-treatment-reduce-arrest-and-severity-of-arrest-charges-an-analysis-of-arrest-records
#19
Robert P Schwartz, Sharon M Kelly, Shannon Gwinn Mitchell, Jan Gryczynski, Kevin E O'Grady, Jerome H Jaffe
This is an analysis of the odds of arrest, severity of charges, and factors predicting these outcomes in the year after methadone treatment entry using arrest records of patients (N=289) participating in two opioid treatment programs (OTPs) in Baltimore, MD as part of a previously-reported study. Baseline Addiction Severity Index data were examined along with publicly-available dates of arrest and arrest charges from the year before and after OTP entry. Severity of charges was rated independently by three researchers using a 1-7 point scale...
September 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28957756/using-nominal-group-technique-among-clinical-providers-to-identify-barriers-and-prioritize-solutions-to-scaling-up-opioid-agonist-therapies-in-ukraine
#20
Lynn Madden, Martha J Bojko, Scott Farnum, Alyona Mazhnaya, Tatiana Fomenko, Ruthanne Marcus, Declan Barry, Irina Ivanchuk, Viktor Kolomiets, Sergey Filippovych, Sergey Dvoryak, Frederick L Altice
BACKGROUND: Opioid agonist therapies (OAT) like methadone and buprenorphine maintenance treatment remain markedly under-scaled in Ukraine despite adequate funding. Clinicians and administrators were assembled as part of an implementation science strategy to scale-up OAT using the Network for Improvement of Addiction Treatment (NIATx) approach. METHODS: Nominal Group Technique (NGT), a key ingredient of the NIATx toolkit, was directed by three trained coaches within a learning collaborative of 18 OAT clinicians and administrators to identify barriers to increase OAT capacity at the regional "oblast" level, develop solutions, and prioritize local change projects...
September 25, 2017: International Journal on Drug Policy
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