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Methadone

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https://www.readbyqxmd.com/read/27913280/neuropsychological-functioning-and-chronic-methadone-use-a-systematic-review-and-meta-analysis
#1
REVIEW
A Baldacchino, M Armanyous, D J K Balfour, G Humphris, K Matthews
INTRODUCTION: There is a presumption that neurocognition is commonly impaired in chronic methadone exposed individuals (CM) when compared with healthy controls (HP). Additionally, it remains unclear if short term (<1year) abstinence (AP) is associated with an altered cognitive profile when compared with CM. METHOD: A random effect model approach was used on data assembled into the Comprehensive Meta-Analysis programme. Cohen's d effect sizes and a significance levels of p<0...
November 29, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27907936/early-treatment-for-neonatal-abstinence-syndrome-a-palliative-approach
#2
Jennifer Hudson, Rachel Mayo, Lori Dickes, Liwei Chen, Windsor Westbrook Sherrill, Julie Summey, Bradley Dalton, Kindal Dankovich
Objective To describe medical, safety, and health care utilization outcomes associated with an early treatment model for neonatal opioid withdrawal. Study Design This is a retrospective review of 117 opioid-exposed infants born in a large regional hospital and treated in the level I nursery with methadone initiated within 48 hours of birth. Results For this cohort, mean length of stay was 8.3 days. Hospital safety events were infrequent; there were no medication errors or deaths. Within 30 days of discharge, 14% of infants visited the emergency department; 7% were readmitted...
December 1, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27903358/-comparison-of-genotypes-of-hepatitis-c-virus-between-chinese-and-burmese-drug-users-living-in-dehong-prefecture-yunnan-province
#3
Y K Wang, K D Feng, J B Wang, Z M Zhang, R H Tang, R H Ye, J N Zhang, Y C Yang, M F Qiu, S Duan
Objective: To analyze the distribution of hepatitis C virus (HCV) genotypes among Chinese and Burmese drug users in Dehong Prefecture, Yunnan Province. Methods: Plasma specimens and relevant epidemiological data were collected from 7 545 drug users attending rehabilitation centers and methadone clinics in Dehong Prefecture from January to September in 2015, of which 752 were positive for HCV antibodies. HCV RNA was then extracted from 139 random specimens (64 Burmese and 75 Chinese) and the CE1 and NS5B regions were amplified by nested PCR...
November 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27903083/club-drugs-and-alcohol-abuse-predicted-dropout-and-poor-adherence-among-methadone-maintenance-treatment-patients-in-guangzhou-china
#4
Di Liu, Jing Gu, Huifang Xu, Chun Hao, Mingxu Jiao, Xiao Zhang, Yuteng Zhao, Babbitt Andrew, Yuantao Hao
Club drugs and alcohol abuse are prevalent among methadone maintenance treatment (MMT) patients. However, little is known about the association between these abuse and treatment outcomes among MMT patients. The aim of this study was to examine the prevalence of club drugs and alcohol abuse among MMT patients and to investigate the associations between these abuse and treatment outcomes - dropout and poor adherence. In this one-year cohort study conducting in Guangzhou, China, data including background characteristics, club drugs use in the last six months, alcohol use history and treatment-related information was collected...
November 30, 2016: AIDS Care
https://www.readbyqxmd.com/read/27903034/prescription-drug-abuse-a-timely-update
#5
Benny Monheit, Danusia Pietrzak, Sandra Hocking
BACKGROUND: Prescription drug abuse is a rising problem in Australia and pharmaceutical drugs have been the most frequent contributors to overdose deaths in Victoria in recent years. OBJECTIVE: The objectives of this article are to examine the main prescription drugs contributing to overdose deaths and to consider how doctors may help in reducing this problem. DISCUSSION: Data from the Coroners Court of Victoria list the main drugs that contributed to drug-related deaths in 2009-15...
December 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27898496/distinctive-trajectories-of-opioid-use-over-an-extended-follow-up-of-patients-in-a-multisite-trial-on-buprenorphine%C3%A2-%C3%A2-naloxone-and-methadone
#6
Yih-Ing Hser, David Huang, Andrew J Saxon, George Woody, Andrew L Moskowitz, Abigail G Matthews, Walter Ling
OBJECTIVES: Uncovering heterogeneities in longitudinal patterns (trajectories) of opioid use among individuals with opioid use disorder can increase our understanding of disease progression and treatment responses to improve care. The present study aims to identify distinctive opioid use trajectories and factors associated with these patterns among participants randomized to treatment with methadone (MET) or buprenorphine + naloxone (BUP). METHODS: Growth mixture modeling was applied to identify distinctive opioid use trajectories among 795 opioid users after their enrollment in a multisite trial during 2006 to 2009, with follow-up interviews conducted during 2011 to 2014...
November 24, 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27889436/wide-variation-found-in-care-of-opioid-exposed-newborns
#7
Debra L Bogen, Bonny L Whalen, Laura R Kair, Mark Vining, Beth A King
OBJECTIVE: Standardized practices for the management of neonatal abstinence syndrome (NAS) are associated with shorter lengths of stay, but optimal protocols are not established. We sought to identify practice variations for newborns with in utero chronic opioid exposure among hospitals in the Better Outcomes Through Research for Newborns (BORN) network. METHODS: Nursery site leaders completed a survey about hospitals' policies and practices regarding care for infants with chronic opioid exposure (≥3 weeks)...
November 23, 2016: Academic Pediatrics
https://www.readbyqxmd.com/read/27882206/willingness-to-receive-treatment-for-hepatitis-c-among-injecting-drug-users-on-methadone-program-implications-for-education-and-treatment
#8
Zahra Alam-Mehrjerdi, Afsaneh Moradi, Fenglian Xu, Mehran Zarghami, Javad Salehi-Fadardi, Kate Dolan
BACKGROUND: Hepatitis C virus (HCV) is common among people who inject drugs (PWID) on methadoneprogram in Iran (Persia). However, a few PWID on methadone program report willingness to receive HCVtreatment. This study aimed to assess the factors which were associated with willingness to receive HCVtreatment in a group of PWID on methadone program in Iran. METHODS: We surveyed 187 PWID at seven drops in centers in Tehran, Iran. Details of demographiccharacteristics, drug use, injection, HCV, and drug treatment history were collected using a 25-itemquestionnaire...
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27882205/sleep-disorders-in-methadone-maintenance-treatment-volunteers-and-opium-dependent-patients
#9
Habibolah Khazaie, Farid Najafi, Mohammad Rasoul Ghadami, Atena Azami, Marzieh Nasouri, Masoud Tahmasian, Behnam Khaledi-Paveh
BACKGROUND: The relationship between substance use and sleep is bidirectional. Substance use directly causessleep disturbances, and sleep problems are a critical factor in substance-use relapse. METHODS: This study evaluated sleep disorders in 65 methadone maintenance treatment (MMT) patients, and61 opium-dependent patients who did not receive any treatment between September 2011 and July 2012 inKermanshah, Iran. Both groups filled out the Pittsburgh Sleep Quality Index (PSQI) and Global SleepAssessment Questionnaire (GSAQ)...
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27872705/sophora-alopecuroides-l-var-alopecuroides-alleviates-morphine-withdrawal-syndrome-in-mice-involvement-of-alkaloid-fraction-and-matrine
#10
Saeed Kianbakht, Fataneh Hashem Dabaghian
OBJECTIVES: Evaluation of the Sophora alopecuroides var. alopecuroides seed effects on morphine withdrawal syndrome in mice and determination of the alkaloid composition of the seed total extract. MATERIALS AND METHODS: The effects of the seed total extract, alkaloid fraction and major compound matrine on the mice morphine withdrawal syndrome were compared to saline and methadone. Mice were made dependent on morphine by morphine sulfate injection 3 times a day for 3 days...
October 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27871509/a-cross-sectional-study-of-preoperative-medication-adherence-and-early-postoperative-recovery
#11
Anthony P Notaras, Elisabeth Demetriou, Jessica Galvin, Erez Ben-Menachem
STUDY OBJECTIVE: To quantify the impact of preoperative medication adherence on recovery length of stays and complication rates. DESIGN: Cross-sectional analytical study. SETTING: Postanesthetic care unit (PACU) of a single-center tertiary hospital. PATIENTS: Surgical patients admitted for surgery at our institution over a 4-month period. INTERVENTION: A data collection tool was used to collect demographic data, length of stay in recovery, prespecified conditions likely to impact on PACU recovery (chronic pain, insulin-dependent diabetes, epilepsy, hypertension, on a methadone program, and Parkinson disease), medication compliance, and complications in PACU...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27870477/ascending-single-dose-double-blind-placebo-controlled-safety-study-of-noribogaine-in-opioid-dependent-patients
#12
Paul Glue, Gavin Cape, Donna Tunnicliff, Michelle Lockhart, Fred Lam, Noelyn Hung, C Tak Hung, Sarah Harland, Jane Devane, R S Crockett, John Howes, Borje Darpo, Meijian Zhou, Holger Weis, Lawrence Friedhoff
Ibogaine is a psychoactive substance that may reduce opioid withdrawal symptoms. This was the first clinical trial of noribogaine, ibogaine's active metabolite, in patients established on methadone opioid substitution therapy (OST). In this randomized, double-blind, placebo-controlled single ascending-dose study, we evaluated the safety, tolerability, and pharmacokinetics of noribogaine in 27 patients seeking to discontinue methadone OST who had been switched to morphine during the previous week. Noribogaine doses were 60, 120, or 180 mg (n = 6/dose level) or matching placebo (n = 3/dose level)...
November 2016: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/27862608/assessing-prescription-drug-abuse-using-functional-principal-component-analysis-fpca-of-wastewater-data
#13
Stefania Salvatore, Jo Røislien, Jose A Baz-Lomba, Jørgen G Bramness
BACKGROUND: Wastewater-based epidemiology is an alternative method for estimating the collective drug use in a community. We applied functional data analysis, a statistical framework developed for analysing curve data, to investigate weekly temporal patterns in wastewater measurements of three prescription drugs with known abuse potential: methadone, oxazepam and methylphenidate, comparing them to positive and negative control drugs. METHODS: Sewage samples were collected in February 2014 from a wastewater treatment plant in Oslo, Norway...
November 11, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27859761/methadone-complications-amongst-opioid-dependent-patients-in-malaysia-a-case-series
#14
Philip George, Balasingam Vicknasingam, Sivakumar Thurairajasingam, Parameswaran Ramasamy, Haslina Mohd Yusof, Mohd Azhar Bin Mohd Yasin, Zia U Bahkt Sultan Shah
INTRODUCTION AND AIMS: Opioid dependence remains the main type of illicit substance used in Malaysia, which has an estimated 187 771 opiate users. There are currently 333 active methadone maintenance treatment centres nationwide. Although methadone has proven to be an effective maintenance therapy, it has clinical concerns which can have an impact on its effectiveness and safety. DESIGN, METHODS AND RESULTS: A case series of seven patients from Malaysian private and public hospital settings who had an adverse reaction with methadone is discussed...
November 8, 2016: Drug and Alcohol Review
https://www.readbyqxmd.com/read/27856784/usefulness-of-an-injectable-anaesthetic-protocol-for-semen-collection-through-urethral-catheterisation-in-domestic-cats
#15
Maria Carmela Pisu, Patrizia Ponzio, Chiara Rovella, Michela Baravalle, Maria Cristina Veronesi
OBJECTIVES: Although less often requested in comparison with dogs, the collection of semen in cats can be necessary for artificial insemination, for semen evaluation in tom cats used for breeding and for semen storage. Urethral catheterisation after pharmacological induction with medetomidine has proved to be useful for the collection of semen in domestic cats. However, most of the previously used protocols require the administration of high doses of medetomidine that can increase the risk of side effects, especially on the cardiovascular system...
November 17, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/27855842/methadone-maintenance-treatment-may-be-associated-with-bruxism-in-male-prisoners
#16
Daniele Manfredini
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Methadone treatment, bruxism, and temporomandibular disorders among male prisoners. Enguelberg-Gabbay JV, Schapir L, Israeli Y, Hermesh H, Weizman A, Winocur E. Eur J Oral Sci 2016;124(3): 266-71. SOURCE OF FUNDING: None TYPE OF STUDY/DESIGN: Cross-sectional study.
September 2016: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/27855712/blood-pressure-and-heart-rate-during-ovariohysterectomy-in-pyometra-and-control-dogs-a-preliminary-investigation
#17
Odd Viking Höglund, Johanna Lövebrant, Ulf Olsson, Katja Höglund
BACKGROUND: Surgery causes a stress response, a physiologic response to trauma. The intraoperative surgical stress response in dogs diagnosed with pyometra has not previously been described. The aim of this study was to investigate the intraoperative surgical stress response, assessed by blood pressure and heart rate measurements, in dogs diagnosed with pyometra and healthy controls. All dogs were premedicated with acepromazine and methadone, anaesthesia was induced with propofol and maintained with isoflurane, where after the dogs were subjected to ovariohysterectomy...
November 17, 2016: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/27846264/hepatitis-c-treatment-uptake-among-patients-who-have-received-opioid-substitution-treatment-a-population-based-study
#18
Håvard Midgard, Jørgen G Bramness, Svetlana Skurtveit, John W Haukeland, Olav Dalgard
BACKGROUND AND AIMS: There is limited data on hepatitis C (HCV) treatment uptake among people who inject drugs including individuals receiving opioid substitution treatment (OST). We aimed to calculate cumulative HCV treatment uptake, estimate annual treatment rates, and identify factors associated with HCV treatment among individuals who have received OST in Norway. METHODS: This observational study was based on linked data from The Norwegian Prescription Database and The Norwegian Surveillance System for Communicable Diseases between 2004 and 2013...
2016: PloS One
https://www.readbyqxmd.com/read/27844471/clinically-relevant-concentrations-of-opioids-for-in-vitro-studies
#19
Jason W Boland, A Graham Pockley
OBJECTIVES: Numerous in vitro studies have evaluated the influence of opioids on many biological and immunological processes. The concentrations that have been used in these studies span a large range and often do not reflect levels that are present in the relevant patient groups. This article reviews the literature concerning the concentrations of opioids that are detected in patients so that the concentrations of opioids that are used for in vitro studies can better reflect those that are present clinically...
September 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27843967/prevalence-of-pulmonary-edema-among-the-deceased-cases-with-acute-methadone-poisoning-a-report-from-iran
#20
Nastaran Eizadi-Mood, Seyed Amir Hossein Madani Naeini, Mahrang Hedaiaty, Ali Mohammad Sabzghabaee, Maryam Moudi
OBJECTIVE: Methadone poisoning is common in our society, mainly in drug addicts. One of its lethal complications is pulmonary edema. Therefore, we evaluated the prevalence of pulmonary edema in the deceased cases with methadone poisoning and its possible relationship with some medical variables. METHODS: In this cross-sectional study which was done in 2014, we have investigated the deceased patients with methadone toxicity who underwent autopsy at Isfahan Forensic Medicine Department (Iran)...
October 2016: Journal of Research in Pharmacy Practice
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