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https://www.readbyqxmd.com/read/29214422/emu-oil-improves-clinical-indicators-of-disease-in-a-mouse-model-of-colitis-associated-colorectal-cancer
#1
Lauren C Chartier, Gordon S Howarth, Ian C Lawrance, Debbie Trinder, Scott J Barker, Suzanne Mashtoub
BACKGROUND/AIMS: Ulcerative colitis is a remitting and relapsing inflammatory bowel disorder. Current treatments are limited, and if poorly controlled, colitis may progress to colorectal cancer. Previously, Emu Oil protected the intestine in experimental models of gut damage. We aimed to determine whether Emu Oil could reduce the severity of chronic colitis and prevent the onset of neoplasia in a mouse model of colitis-associated colorectal cancer. METHODS: Female C57BL/6 mice were injected (day 0) with azoxymethane, followed by ad libitum access to three dextran sulfate sodium/water cycles (7 days of dextran sulfate sodium and 14 days of water)...
December 6, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29124097/safety-data-on-single-application-of-emu-and-macadamia-nut-oil-on-human-skin
#2
Tadayoshi Miyashita, Ryosuke Koizumi, Yoshimasa Sagane, Kazuhiro Minami, Minoru Ito, Toshihiro Watanabe, Koichi Niwa
This data article provides the results of skin sensitization testing for emu and macadamia nut oil on 20 participants (ages 22-59 years old), including 3 men and 17 women. The test was carried out by performing a standard patch test using a Finn Chamber on Scanpor tape. The oils were applied to the participant's back using the tape and left in place for 24 h. After 1- and 24-h from removal of the tape, the reaction of the participant's skin was judged based on a scoring method recommended by Japanese Patch Test Research Group...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/28830252/macrophage-repolarization-using-emu-oil-based-electrospun-nanofibers-possible-application-in-regenerative-medicine
#3
Reza Zamani, Younes Pilehvar-Soltanahmadi, Effat Alizadeh, Nosratollah Zarghami
In the regenerative medicine therapies, the availability of engineered scaffolds that modulate inflammatory states is highly required. The aim of this study was to evaluate the efficiency of electrospun nanofibrous scaffolds containing natural substances with anti-inflammatory properties such as Emu oil (EO) to control inflammation and re-polarization of macrophages toward M2 anti-inflammatory phonotype. For this purpose, bead free and smooth EO-blended PCL/PEG electrospun nanofibrous mats were successfully fabricated and characterized using FE-SEM, FTIR, and Universal Testing Machine...
August 23, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28718680/development-of-emu-oil-loaded-pcl-collagen-bioactive-nanofibers-for-proliferation-and-stemness-preservation-of-human-adipose-derived-stem-cells-possible-application-in-regenerative-medicine
#4
Kazem Nejati-Koshki, Younes Pilehvar-Soltanahmadi, Effat Alizadeh, Abbas Ebrahimi-Kalan, Yousef Mortazavi, Nosratollah Zarghami
Adipose tissue-derived stem cells (ASCs) are promising candidate in stem cell therapies, and maintaining their stemness potential is vital to achieve effective treatment. Natural-based scaffolds have been recently attracted increasing attention in nanomedicine and drug delivery. In the present study, a polymeric nanofibrous scaffold was developed based on the polycaprolactone/Collagen (PCL/Coll) containing Emu oil as a bioactive material to induce the proliferation of ASCs, while simultaneously preserving the stemness property of those cells...
December 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28691132/randomized-phase-ii-placebo-controlled-study-to-evaluate-the-efficacy-of-topical-pure-emu-oil-for-joint-pain-related-to-adjuvant-aromatase-inhibitor-use-in-postmenopausal-women-with-early-breast-cancer-just-joints-under-study
#5
Arlene Chan, R De Boer, A Gan, P Willsher, R Martin, Y Zissiadis, K Miller, A Bauwens, D Hastrich
PURPOSE: Aromatase inhibitors are standard of care in women with hormone receptor-positive early breast cancer. Published evidence demonstrates that adverse effects may have an impact on drug compliance, with arthralgias being one of the most commonly reported adverse effects. METHODS: Eligible patients were postmenopausal women who had experienced arthralgia following initiation of an aromatase inhibitor. Patients who experienced arthralgias following a minimum of a 3-month treatment on the aromatase inhibitor were randomized to emu oil or placebo oil...
December 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28527695/cytoprotection-proliferation-and-epidermal-differentiation-of-adipose-tissue-derived-stem-cells-on-emu-oil-based-electrospun-nanofibrous-mat
#6
Younes Pilehvar-Soltanahmadi, Mohammad Nouri, Mikaël M Martino, Amir Fattahi, Effat Alizadeh, Masoud Darabi, Mohammad Rahmati-Yamchi, Nosratollah Zarghami
Electrospun nanofibrous scaffolds containing natural substances with wound healing properties such as Emu oil (EO) may have a great potential for increasing the efficiency of stem cell-based skin bioengineering. For this purpose, EO blended PCL/PEG electrospun nanofibrous mats were successfully fabricated and characterized using FE-SEM, FTIR and Universal Testing Machine. The efficiency of the scaffolds in supporting the adherence, cytoprotection, proliferation and differentiation of adipose tissue-derived stem cells (ADSCs) to keratinocyte was evaluated...
August 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28527394/elucidation-of-penetration-enhancement-mechanism-of-emu-oil-using-ftir-microspectroscopy-at-emira-laboratory-of-sesame-synchrotron
#7
Randa S H Mansour, Alsayed A Sallam, Imad I Hamdan, Enam A Khalil, Ibraheem Yousef
It has been proposed that Emu oil possesses skin permeation-enhancing effect. This study aimed to address its possible penetration enhancement mechanism(s) using IR microscopy, in accordance with LPP theory. The penetration of Emu oil through the layers of human skin was accomplished by monitoring oil-IR characteristic feature at 3006cm(-1). The unsaturated components of Emu oil accumulated at about 270μm depth of skin surface. The interaction of Emu oil with lipid and protein constituents of SC was investigated in comparison with a commonly used enhancer, IPM...
May 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27924292/data-on-melanin-production-in-b16f1-melanoma-cells-in-the-presence-of-emu-oil
#8
Minoru Ito, Kazuhiro Minami, Yoshimasa Sagane, Toshihiro Watanabe, Koichi Niwa
Here, we present data on the effects of emu oil, obtained from emu (Dromaius novaehollandiae) fat deposits, on melanogenesis in B16F1 murine melanoma cells. The cells were cultured in media containing different concentrations of emu oil, and the melanin content of these cells was measured using a microplate reader. Next, melanin content was measured for cells cultured with α-melanocyte-stimulating hormone. This article reports the different melanin contents as μg melanin/mg cellular protein, by using bar graphs with error bars...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27618153/emu-oil-combined-with-lyprinol%C3%A2-reduces-small-intestinal-damage-in-a-rat-model-of-chemotherapy-induced-mucositis
#9
Suzanne Mashtoub, Lorrinne S Lampton, Georgina L Eden, Ker Y Cheah, Kerry A Lymn, Juliana E Bajic, Gordon S Howarth
Chemotherapy-induced mucositis is characterized by inflammation and ulcerating lesions lining the alimentary tract. Emu Oil and Lyprinol™ have independently demonstrated their therapeutic potential in intestinal inflammatory disorders, including mucositis. We investigated Emu Oil and Lyprinol™ in combination for their further potential to alleviate chemotherapy-induced mucositis in rats. Rats were gavaged with (1 ml) water, Olive Oil, Emu Oil + Olive Oil, Lyprinol™ + Olive Oil or Emu Oil + Lyprinol™ from Days 0 to 7, injected with saline (control) or 5-Fluorouracil (5-FU) on Day 5 and euthanized on Day 8...
October 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27383819/visual-pigments-in-a-palaeognath-bird-the-emu-dromaius-novaehollandiae-implications-for-spectral-sensitivity-and-the-origin-of-ultraviolet-vision
#10
Nathan S Hart, Jessica K Mountford, Wayne I L Davies, Shaun P Collin, David M Hunt
A comprehensive description of the spectral characteristics of retinal photoreceptors in palaeognaths is lacking. Moreover, controversy exists with respect to the spectral sensitivity of the short-wavelength-sensitive-1 (SWS1) opsin-based visual pigment expressed in one type of single cone: previous microspectrophotometric (MSP) measurements in the ostrich (Struthio camelus) suggested a violet-sensitive (VS) SWS1 pigment, but all palaeognath SWS1 opsin sequences obtained to date (including the ostrich) imply that the visual pigment is ultraviolet-sensitive (UVS)...
July 13, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27191775/in-situ-dispersion-of-non-aqueous-fe3o4-nanocolloids-by-microdroplet-coalescence-and-their-use-in-the-preparation-of-magnetic-composite-particles
#11
Le Du, Yujun Wang, Jianhong Xu, Chun Shen, Guangsheng Luo
Monodispersity and size uniformity are critical issues for nanoparticles, especially for the inorganic particles dispersed in organic carriers serving as the precursor of composites. Herein, for the first time, we have developed a method based on flow-induced droplet coalescence for in situ dispersion of surface-modified Fe3O4 nanoparticles to prepare Fe3O4/polystyrene (Fe3O4/PS) composite particles. A plate-type microchannel was constructed to initiate droplet coalescence for reducing the water-oil interfacial area and for dispersing Fe3O4 nanoparticles into the precursor suspensions...
June 21, 2016: Soft Matter
https://www.readbyqxmd.com/read/27178879/amelioration-of-fca-induced-arthritis-on-topical-application-of-curcumin-in-combination-with-emu-oil
#12
Manish Kumar Jeengar, Shweta Shrivastava, S Chandra Mouli Veeravalli, V G M Naidu, Ramakrishna Sistla
OBJECTIVE: The aim of the present study was to investigate the skin penetration potential of emu oil and the possibility of enhancing the antiarthritic potential of lipophilic bioactive curcumin, which has poor permeability through biological membranes. METHODS: Solubility and ex vivo skin permeation studies were performed with water, corn oil, and emu oil as a vehicle using curcumin as a model drug. Carrageenan induced inflammation and Freund's complete adjuvant-induced arthritic rat models were used to evaluate enhanced antiinflammatory and antiarthritic effect of curcumin in combination of emu oil via topical route...
September 2016: Nutrition
https://www.readbyqxmd.com/read/27109049/emu-oil-based-nano-emulgel-for-topical-delivery-of-curcumin
#13
COMPARATIVE STUDY
Manish Kumar Jeengar, Sri Vishnu Kiran Rompicharla, Shweta Shrivastava, Naveen Chella, Nalini R Shastri, V G M Naidu, Ramakrishna Sistla
Curcumin and emu oil derived from emu bird (Dromaius novaehollandiae) has shown promising results against inflammation. However, the delivery of curcumin is hindered due to low solubility and poor permeation. In addition, till date the role of emu oil in drug delivery has not been explored systemically. Hence, the current investigation was designed to evaluate the anti-inflammatory potential of curcumin in combination with emu oil from a nanoemulgel formulation in experimental inflammation and arthritic in vivo models...
June 15, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27069472/effects-of-topical-emu-oil-on-burn-wounds-in-the-skin-of-balb-c-mice
#14
Mohammad Afshar, Reza Ghaderi, Mahmoud Zardast, Parvin Delshad
The goal of this study was to determine the effect of topical Emu oil on the healing of burn wounds and hair follicle restoration in superficial II-degree burns in the skin of Balb/c mice. Thirty-two male Balb/c mice with burns on the back of the neck were divided into two groups: The Emu oil group received topical Emu oil twice daily, whereas the control was left untreated. Skin biopsies were obtained on days 4, 7, 10, and 14 of the experiment. Then the specimens were viewed with Olympus SZX research microscope...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/26852336/emu-oil-offers-protection-in-crohn-s-disease-model-in-rats
#15
Bhaskar Vemu, S Selvasubramanian, V Pandiyan
BACKGROUND: Emu oil is a product of animal origin used for the treatment of inflammation, burns etc. as a part of aboriginal medicine in Australia. Crohn's disease is a common inflammatory manifestation in humans and other animal species relating to the ulceration and digestive disturbances in upper gastro-intestinal tract. Aloe vera is commonly used substance from plant sources for inflammation, wound healing and various other properties. Given the difference in the source of the substances all the while playing a similar therapeutic role in different parts of the world, the present investigation was undertaken to evaluate the protective effect of aloe vera and emu oil alone and in combination; in comparison to sulfasalazine (Allopathic drug) as an alternative for the treatment of Crohn's disease...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26217022/ratite-oils-promote-keratinocyte-cell-growth-and-inhibit-leukocyte-activation
#16
Darin C Bennett, Gigi Leung, Eddy Wang, Sam Ma, Blanche K K Lo, Kevin J McElwee, Kimberly M Cheng
Traditionally, native Australian aborigines have used emu oil for the treatment of inflammation and to accelerate wound healing. Studies on mice suggest that topically applied emu oil may have anti-inflammatory properties and may promote wound healing. We investigated the effects of ratite oils (6 emu, 3 ostrich, 1 rhea) on immortalized human keratinocytes (HaCaT cells) in vitro by culturing the cells in media with oil concentrations of 0%, 0.5%, and 1.0%. Peking duck, tea tree, and olive oils were used as comparative controls...
September 2015: Poultry Science
https://www.readbyqxmd.com/read/26161938/penetration-enhancing-effects-of-selected-natural-oils-utilized-in-topical-dosage-forms
#17
Joe M Viljoen, Amé Cowley, Jan du Preez, Minja Gerber, Jeanetta du Plessis
CONTEXT: Various natural products, including oils, have been utilized as penetration enhancers due to their "safety profiles". These oils contain fatty acids promoting skin permeability through lipid fluidization within the stratum corneum; and might therefore be able to effectively enhance transdermal drug delivery. OBJECTIVE: We investigated possible penetration enhancing properties of selected oils, utilizing flurbiprofen as marker compound in emulgel formulations...
2015: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/26153074/chemical-profiling-and-anti-psoriatic-activity-of-methanolic-extract-of-andrographis-nallamalayana-j-l-ellis
#18
Sunitha Parlapally, Neeraja Cherukupalli, Sudarshana Reddy Bhumireddy, Prabhakar Sripadi, Ravindernath Anisetti, Charu Chandra Giri, Venkateswara Rao Khareedu, Dashavantha Reddy Vudem
Andrographis nallamalayana is being widely used as tribal medicine in the treatment of leucoderma and mouth ulcers. Chemical profiling of methanolic extract of the whole plant (PE), using GC-MS and LC-MS, revealed the presence of compounds viz. α-tocopherol, β-sitosterol, tetradecanoic acid, monostearin, flavones/flavanones and their glycosides, chromones, etc. Topical application of imiquimod on the dorsal portion of male BALB/C mice resulted in the development of psoriatic symptoms (erythema, scaling, thickening and folding) with a mean disease activity index (DAI) of >7...
June 2016: Natural Product Research
https://www.readbyqxmd.com/read/26080458/efficacy-of-topical-application-of-emu-oil-on-areola-skin-barrier-in-breastfeeding-women
#19
Vincenzo Zanardo, David Giarrizzo, Luigi Maiolo, Gianluca Straface
Appropriate hydration and skin surface pH are of fundamental importance in preventing areola skin barrier damage and breastfeeding success. We studied the dermal effects of emu oil on areola skin soon after birth in 70 at-term breastfeeding mothers by noninvasive bioengineering method. Emu oil-based cream was found to be effective in improving stratum corneum hydration of breast areolae (mean ± standard deviation, from 56.9 ± 18.2 to 65.0 ± 17.2 conventional units, P < .003) and did not affect skin pH, temperature, or elasticity...
January 2016: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/25936812/double-blind-placebo-controlled-pilot-study-of-processed-ultra-emu-oil-versus-placebo-in-the-prevention-of-radiation-dermatitis
#20
RANDOMIZED CONTROLLED TRIAL
Denise C Rollmann, Paul J Novotny, Ivy A Petersen, Yolanda I Garces, Heather J Bauer, Elizabeth S Yan, Dietlind Wahner-Roedler, Ann Vincent, Jeff A Sloan, Nadia N Issa Laack
PURPOSE: The purpose of this single-institution pilot study was to evaluate the feasibility and safety of an oil-based skin agent, Ultra Emu Oil, on skin-related toxicity in patients undergoing radiation therapy to the breast or chest wall. METHODS AND MATERIALS: Patients were randomized 2:1 in a double-blind fashion and were instructed to apply processed Ultra Emu Oil or placebo (cottonseed oil) twice daily during the course of radiation therapy. The oils were applied before the third fraction and continued for 6 weeks after completion of treatment...
July 1, 2015: International Journal of Radiation Oncology, Biology, Physics
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