keyword
https://read.qxmd.com/read/38542713/organosulfur-compounds-in-colorectal-cancer-prevention-and-progression
#1
REVIEW
Patrick L McAlpine, Javier Fernández, Claudio J Villar, Felipe Lombó
This work represents an overview of the current investigations involving organosulfur compounds and colorectal cancer. The molecules discussed in this review have been investigated regarding their impact on colorectal cancer directly, at the in vitro, in vivo, and clinical stages. Organosulfur compounds may have indirect effects on colorectal cancer, such as due to their modulating effects on the intestinal microbiota or their positive effects on intestinal mucosal health. Here, we focus on their direct effects via the repression of multidrug resistance proteins, triggering of apoptosis (via the inhibition of histone deacetylases, increases in reactive oxygen species, p53 activation, β-catenin inhibition, damage in the mitochondrial membrane, etc...
March 11, 2024: Nutrients
https://read.qxmd.com/read/38540739/overexpression-of-s30-ribosomal-protein-leads-to-transcriptional-and-metabolic-changes-that-affect-plant-development-and-responses-to-stress
#2
JOURNAL ARTICLE
Alin Finkelshtein, Hala Khamesa-Israelov, Daniel A Chamovitz
ICT1 is an Arabidopsis thaliana line that overexpresses the gene encoding the S30 ribosomal subunit, leading to tolerance to exogenous indole-3-carbinol. Indole-3-carbinol (I3C) is a protective chemical formed as a breakdown of I3M in cruciferous vegetables. The overexpression of S30 in ICT1 results in transcriptional changes that prime the plant for the I3C, or biotic insult. Emerging evidence suggests that ribosomal proteins play important extra-ribosomal roles in various biochemical and developmental processes, such as transcription and stress resistance...
March 7, 2024: Biomolecules
https://read.qxmd.com/read/38472809/application-of-tryptophan-and-methionine-in-broccoli-seedlings-enhances-formation-of-anticancer-compounds-sulforaphane-and-indole-3-carbinol-and-promotes-growth
#3
JOURNAL ARTICLE
Rui Li, Zihuan Zhou, Xiaofei Zhao, Jing Li
Broccoli is a popular cruciferous vegetable that is well known for its abundant health-promoting biochemicals. The most important of these beneficial biochemicals are glucosinolates, including glucoraphanin and glucobrassicin. Glucoraphanin and glucobrassicin can be broken down by myrosinases into sulforaphane and indole-3-carbinol, which have been demonstrated to have potent cancer-preventive properties. Efforts to increase glucoraphanin in broccoli seedlings have long been a focus; however, increasing glucoraphanin and glucobrassicin simultaneously, as well as enhancing myrosinase activity to release more sulforaphane and indole-3-carbinol, have yet to be investigated...
February 24, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38397081/aryl-hydrocarbon-receptor-regulates-muc2-production-independently-of-il-22-during-colitis
#4
JOURNAL ARTICLE
Archana Saxena, Chandani Mitchell, Raymond Bogdon, Kasie Roark, Kiesha Wilson, Shanieka Staley, Michelle Hailey, Michal Claire Williams, Alex Rutkovsky, Prakash Nagarkatti, Mitzi Nagarkatti, Philip Brandon Busbee
We previously reported that an aryl hydrocarbon receptor (AhR) ligand, indole-3-carbinol (I3C), was effective at reducing colitis severity through immune cell-mediated interleukin-22 (IL-22) production. Intestinal epithelial cells (IECs) are also involved in regulating colitis, so we investigated their AhR-mediated mechanisms in the current report. A transcriptome analysis of IECs in wildtype (WT) mice revealed that during colitis, I3C regulated select mucin proteins, which could be attributed to goblet cell development...
February 18, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38391532/natural-products-biosynthesis-by-streptomyces-netropsis-imv-ac-5025-under-exogenous-sterol-action
#5
JOURNAL ARTICLE
Mariia Loboda, Liudmyla Biliavska, Galyna Iutynska, Jake Newitt, Ruslan Mariychuk
Streptomycetes are known as producers of bioactive substances, particularly antibiotics. Streptomyces netropsis IMV Ac-5025 simultaneously produces different classes of antibiotics, including polyene compounds, phytohormones, and sterols, but the metabolic pathways involved in their biosynthesis are largely understudied. The aim of this work was to explore the biosynthesis of polyene antibiotics, sterols, and phytohormones when the producer is cultivated in a nutrient medium supplemented with exogenous β-sitosterol...
February 1, 2024: Antibiotics
https://read.qxmd.com/read/38326384/indole-3-carbinol-i3c-reduces-apoptosis-and-improves-neurological-function-after-cerebral-ischemia-reperfusion-injury-by-modulating-microglia-inflammation
#6
JOURNAL ARTICLE
Long Peng, Xingjia Zhu, Chenxing Wang, Qiaoji Jiang, Shian Yu, Gaochao Song, Qianqian Liu, Peipei Gong
Indole-3-carbinol(I3C) is a tumor chemopreventive substance that can be extracted from cruciferous vegetables. Indole-3-carbinol (I3C) has been shown to have antioxidant and anti-inflammatory effects. In this study, we investigated the cerebral protective effects of I3C in an in vivo rats model of middle cerebral artery occlusion (MCAO). 8-10 Week-Old male SD rat received I3C (150 mg/kg, once daily) for 3 days and underwent 3 h of middle cerebral artery occlusion (MCAO) followed by reperfusion...
February 7, 2024: Scientific Reports
https://read.qxmd.com/read/38255874/bioaccessible-organosulfur-compounds-in-broccoli-stalks-modulate-the-inflammatory-mediators-involved-in-inflammatory-bowel-disease
#7
JOURNAL ARTICLE
Antonio Costa-Pérez, Paola Sánchez-Bravo, Sonia Medina, Raúl Domínguez-Perles, Cristina García-Viguera
Inflammatory diseases are strongly associated with global morbidity and mortality. Several mediators are involved in this process, including proinflammatory interleukins and cytokines produced by damaged tissues that, somehow, act as initiators of the autoreactive immune response. Bioactive compounds present in plant-based foods and byproducts have been largely considered active agents with the potential to treat or prevent inflammatory diseases, being a valuable alternative to traditional therapeutic agents used nowadays, which present several side effects...
January 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38222639/phytochemicals-in-pancreatic-cancer-treatment-a-machine-learning-study
#8
JOURNAL ARTICLE
Destina Ekingen Genc, Ozlem Ozbek, Burcu Oral, Ramazan Yıldırım, Nazar Ileri Ercan
The discovery of new strategies and novel therapeutic agents is crucial to improving the current treatment methods and increasing the efficacy of cancer therapy. Phytochemicals, naturally occurring bioactive constituents derived from plants, have great potential in preventing and treating various diseases, including cancer. This study reviewed 74 literature studies published between 2006 and 2022 that conducted in vitro cytotoxicity and cell apoptosis analyses of the different concentrations of phytochemicals and their combinations with conventional drugs or supplementary phytochemicals on human pancreatic cell lines...
January 9, 2024: ACS Omega
https://read.qxmd.com/read/38217095/current-understanding-and-future-directions-of-cruciferous-vegetables-and-their-phytochemicals-to-combat-neurological-diseases
#9
REVIEW
Ramakrishna Kakarla, Praditha Karuturi, Queen Siakabinga, Matte Kasi Viswanath, Naresh Dumala, Chakravarthi Guntupalli, Buchi N Nalluri, Kojja Venkateswarlu, Vani Sai Prasanna, Gopichand Gutti, Ganesh Yadagiri, Lohitha Gujjari
Neurological disorders incidences are increasing drastically due to complex pathophysiology, and the nonavailability of disease-modifying agents. Several attempts have been made to identify new potential chemicals to combat these neurological abnormalities. At present, complete abolishment of neurological diseases is not attainable except for symptomatic relief. However, dietary recommendations to help brain development or improvement have increased over the years. In recent times, cruciferous vegetables and their phytochemicals have been identified from preclinical and clinical investigations as potential neuroprotective agents...
January 12, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38129384/wwp1-e3-ligase-at-the-crossroads-of-health-and-disease
#10
REVIEW
Abhayananda Behera, Aramati Bindu Madhava Reddy
The E3 ubiquitin ligase WWP1 (WW Domain-containing E3 Ubiquitin Protein Ligase 1) is a member of the HECT (Homologous to the E6-associated protein Carboxyl Terminus) E3 ligase family. It is conserved across several species and plays crucial roles in various physiological processes, including development, cell growth and proliferation, apoptosis, and differentiation. It exerts its functions through ubiquitination or protein-protein interaction with PPXY-containing proteins. WWP1 plays a role in several human diseases, including cardiac conditions, neurodevelopmental, age-associated osteogenic disorders, infectious diseases, and cancers...
December 21, 2023: Cell Death & Disease
https://read.qxmd.com/read/38068838/potential-dietary-and-therapeutic-strategies-involving-indole-3-carbinole-in-preclinical-models-of-intestinal-inflammation
#11
JOURNAL ARTICLE
Aisha Qazi, Shane Comiskey, Nathan Calzadilla, Fatimah Amin, Anchal Sharma, Ei Khin, Nathaniel Holton, Christopher R Weber, Seema Saksena, Anoop Kumar, Waddah A Alrefai, Ravinder K Gill
Diet-microbiota interactions are emerging as important contributors in the pathogenesis of inflammatory bowel diseases (IBD), characterized by chronic inflammation of the GI tract. The aryl hydrocarbon receptor (AhR) transcription factor regulates xenobiotic metabolism and is activated by exogenous ligands, including indole-3-carbinole (I3C), which is found in cruciferous vegetables. However, studies investigating the impact of dietary I3C and AhR in preclinical models resembling human IBD are lacking. Mice (WT or AhR KO in IECs, 6-8 weeks) or SAMP/YitFC and AKR/J control (4 weeks, m/f) were fed an AhR ligand-depleted or I3C (200 ppm)-supplemented diet...
November 30, 2023: Nutrients
https://read.qxmd.com/read/38052207/dietary-environmental-factors-shape-the-immune-defense-against-cryptosporidium-infection
#12
JOURNAL ARTICLE
Muralidhara Rao Maradana, N Bishara Marzook, Oscar E Diaz, Tapoka Mkandawire, Nicola Laura Diny, Ying Li, Anke Liebert, Kathleen Shah, Mauro Tolaini, Martin Kváč, Brigitta Stockinger, Adam Sateriale
Cryptosporidium is a leading cause of diarrheal-related deaths in children, especially in resource-poor settings. It also targets the immunocompromised, chronically infecting people living with HIV and primary immunodeficiencies. There is no vaccine or effective treatment. Although it is known from human cases and animal models that CD4+ T cells play a role in curbing Cryptosporidium, the role of CD8+ T cells remains to be defined. Using a Cryptosporidium tyzzeri mouse model, we show that gut-resident CD8+ intraepithelial lymphocytes (IELs) confer resistance to parasite growth...
November 28, 2023: Cell Host & Microbe
https://read.qxmd.com/read/38047717/divergent-synthesis-of-difluoromethylated-indole-3-carbinols-bisindolylmethanes-and-indole-3-methanamines
#13
JOURNAL ARTICLE
Yifei Qu, Xiaojia Cai, Yuzhuang Guan, Jiamin Tan, Zhangping Cai, Minyun Liu, Yasi Huang, Jinhui Hu, Wen-Hua Chen, Jia-Qiang Wu
Indole-3-carbinol, bisindolylmethanes (BIMs) and indole-3-methanamines exhibit diverse therapeutic activities. Fluorinated molecules are widely used in pharmaceuticals. Herein we report a facile and straightforward method for the successful synthesis of difluoromethylated indole-3-carbinols, bisindolylmethanes and indole-3-methanamines by a Friedel-Crafts reaction. The reaction involves the in situ generation of difluoroacetaldehyde from difluoroacetaldehyde ethyl hemiacetal in the presence of a base or an acid...
December 4, 2023: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/37986509/indole-3-carbinol-and-chlorogenic-acid-combination-modulates-gut-microbiome-and-attenuates-nonalcoholic-steatohepatitis-in-a-murine-model
#14
JOURNAL ARTICLE
Gabriel P Bacil, Guilherme R Romualdo, Josias Rodrigues, Luís F Barbisan
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, affecting almost 32% of the population and ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). Recent findings indicate that the fast-growing prevalence of NAFLD might be linked to adherence to a Westernized diet (WD), mostly composed of fat/sugar-enriched foods. The WD has been reportedly targeted as a potential driver of gut-liver axis unbalance, suggesting a major role in NASH. On the other hand, bioactive food compounds feature as a potential chemopreventive strategy against NASH, due to their beneficial effects (i...
December 2023: Food Research International
https://read.qxmd.com/read/37844510/a-proof-of-concept-study-on-the-versatility-of-liquid-chromatography-coupled-to-high-resolution-mass-spectrometry-to-screen-for-various-contaminants-and-highlight-markers-of-floral-and-geographical-origin-for-different-honeys
#15
JOURNAL ARTICLE
Yassine Makni, Thierno Diallo, Thierry Guérin, Julien Parinet
The high-resolution mass spectrometry is a powerful analytical tool for improving food safety and authenticity, but still underused in official control laboratories. The present work is a proof-of-concept study overviewing how liquid-chromatography coupled to high-resolution mass spectrometry could be used simultaneously for large-scale screening of contaminants and differentiation of honey samples. Within this study, the samples were extracted using all-in-one QuEChERS-based protocol that allowed for analysis of various anthropogenic contaminants and endogenous compounds...
October 12, 2023: Food Chemistry
https://read.qxmd.com/read/37765203/karaya-gellan-gum-based-bilayer-films-containing-3-3-diindolylmethane-loaded-nanocapsules-a-promising-alternative-to-melanoma-topical-treatment
#16
JOURNAL ARTICLE
Jéssica Brandão Reolon, Camila Parcianello Saccol, Bárbara Felin Osmari, Daiane Britto de Oliveira, Vinicius Costa Prado, Fernanda Licker Cabral, Lucas Saldanha da Rosa, Giancarlo Cervo Rechia, Daniela Bitencourt Rosa Leal, Letícia Cruz
This study aimed to incorporate nanocapsules containing 3,3'-diindolylmethane (DIM) with antitumor activity into a bilayer film of karaya and gellan gums for use in topical melanoma therapy. Nanocarriers and films were prepared by interfacial deposition of the preformed polymer and solvent casting methods, respectively. Incorporating DIM into nanocapsules increased its antitumor potential against human melanoma cells (A-375) (IC50 > 24.00 µg/mL free DIM × 2.89 µg/mL nanocapsules). The films were transparent, hydrophilic (θ < 90°), had homogeneous thickness and weight, and had a DIM content of 106 µg/cm2 ...
August 29, 2023: Pharmaceutics
https://read.qxmd.com/read/37666619/investigating-the-role-of-the-ros-cncc-signaling-pathway-in-the-response-to-xenobiotics-in-spodoptera-frugiperda-using-sf9-cells
#17
JOURNAL ARTICLE
Dries Amezian, Thierry Fricaux, Georges de Sousa, Frank Maiwald, Hannah-Isadora Huditz, Ralf Nauen, Gaëlle Le Goff
Spodoptera frugiperda (fall armyworm, FAW) is an invasive polyphagous lepidopteran pest that has developed sophisticated resistance mechanisms involving detoxification enzymes to eliminate toxic compounds it encounters in its diet including insecticides. Although its inventory of detoxification enzymes is known, the mechanisms that enable an adapted response depending on the toxic compound remain largely unexplored. Sf9 cells were used to investigate the role of the transcription factors, Cap n' collar isoform C (CncC) and musculoaponeurotic fibrosarcoma (Maf) in the regulation of the detoxification response...
September 2023: Pesticide Biochemistry and Physiology
https://read.qxmd.com/read/37640120/nedd4-activates-mitophagy-by-interacting-with-lc3-to-restrain-reactive-oxygen-species-and-apoptosis-in-apostichopus-japonicus-challenged-with-vibrio-splendidus
#18
JOURNAL ARTICLE
Yangxi Xiang, Xuemei Duan, Yina Shao, Lianlian Sun
Mitophagy, the selective degradation of damaged mitochondria by autophagy, plays a crucial role in the survival of coelomocytes in Apostichopus japonicus following Vibrio splendidus infection by suppressing the generation of reactive oxygen species (ROS) and attenuating cell apoptosis. A recent study revealed that reducing the expression of the neural precursor cell-expressed developmentally downregulated gene 4 (NEDD4), an enzyme 3 (E3) ubiquitin ligase, significantly affects mitochondrial degradation. Prior to the present study, the functional role of NEDD4 in marine invertebrates was largely unexplored...
October 2023: Fish & Shellfish Immunology
https://read.qxmd.com/read/37633886/3-3-diindolylmethane-and-indole-3-carbinol-potential-therapeutic-molecules-for-cancer-chemoprevention-and-treatment-via-regulating-cellular-signaling-pathways
#19
REVIEW
Octavio Daniel Reyes-Hernández, Gabriela Figueroa-González, Laura Itzel Quintas-Granados, Stephany Celeste Gutiérrez-Ruíz, Hector Hernández-Parra, Alejandra Romero-Montero, María Luisa Del Prado-Audelo, Sergio Alberto Bernal-Chavez, Hernán Cortés, Sheila I Peña-Corona, Lashyn Kiyekbayeva, Dilek Arslan Ateşşahin, Tamar Goloshvili, Gerardo Leyva-Gómez, Javad Sharifi-Rad
Dietary compounds in cancer prevention have gained significant consideration as a viable method. Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) are heterocyclic and bioactive chemicals found in cruciferous vegetables like broccoli, cauliflower, cabbage, and brussels sprouts. They are synthesized after glycolysis from the glucosinolate structure. Clinical and preclinical trials have evaluated the pharmacokinetic/pharmacodynamic, effectiveness, antioxidant, cancer-preventing (cervical dysplasia, prostate cancer, breast cancer), and anti-tumor activities of I3C and DIM involved with polyphenolic derivatives created in the digestion showing promising results...
August 26, 2023: Cancer Cell International
https://read.qxmd.com/read/37580156/synergistic-action-of-indole-3-carbinol-with-membrane-active-agents-against-multidrug-resistant-gram-negative-bacteria
#20
JOURNAL ARTICLE
Tso-Ping Wang, Tzu-Hui Yeh, Chung-Cheng Lo, Kuan-Hua Lin, Mei-Han Huang, Horng-Ren Lo
The purpose of this study was to evaluate the antimicrobial activity of indole-3-carbinol (I3C) with membrane-active agents, namely carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and EDTA against multidrug-resistant (MDR) Gram-negative bacteria and bacterial persisters. The determination of minimal inhibitory concentration (MIC) showed that I3C was effective against Acinetobacter baumannii (3.13‒6.25 × 10-3 mol l-1), Klebsiella pneumoniae (8 × 10-3 mol l-1), Pseudomonas aeruginosa (6...
August 14, 2023: Letters in Applied Microbiology
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