Octavio Daniel Reyes-Hernández, Gabriela Figueroa-González, Laura Itzel Quintas-Granados, Stephany Celeste Gutiérrez-Ruíz, Hector Hernández-Parra, Alejandra Romero-Montero, María Luisa Del Prado-Audelo, Sergio Alberto Bernal-Chavez, Hernán Cortés, Sheila I Peña-Corona, Lashyn Kiyekbayeva, Dilek Arslan Ateşşahin, Tamar Goloshvili, Gerardo Leyva-Gómez, Javad Sharifi-Rad
Dietary compounds in cancer prevention have gained significant consideration as a viable method. Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) are heterocyclic and bioactive chemicals found in cruciferous vegetables like broccoli, cauliflower, cabbage, and brussels sprouts. They are synthesized after glycolysis from the glucosinolate structure. Clinical and preclinical trials have evaluated the pharmacokinetic/pharmacodynamic, effectiveness, antioxidant, cancer-preventing (cervical dysplasia, prostate cancer, breast cancer), and anti-tumor activities of I3C and DIM involved with polyphenolic derivatives created in the digestion showing promising results...
August 26, 2023: Cancer Cell International