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https://www.readbyqxmd.com/read/28343659/iron-and-zinc-supplementation-does-not-impact-urinary-arsenic-excretion-in-mexican-school-children
#1
Katarzyna Kordas, Aditi Roy, Patricia López, Gonzalo García-Vargas, Mariano E Cebrián, Eunice Vera-Aguilar, Jorge L Rosado
OBJECTIVE: To examine the role of iron and zinc in arsenic excretion and metabolism in children. STUDY DESIGN: An analysis of urinary arsenic (UAs) concentrations from a double-blind randomized trial originally testing the efficacy of iron and zinc for lowering blood lead levels in children. A 2 × 2 factorial design was used, with children randomized individually, stratified by sex and classroom, to receive 30 mg ferrous fumarate (n = 148), 30 mg zinc oxide (n = 144), iron and zinc together (n = 148), or placebo (n = 151)...
March 23, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28340971/glutathione-species-and-metabolomic-prints-in-subjects-with-liver-disease-as-biological-markers-for-the-detection-of-hepatocellular-carcinoma
#2
Juan R Sanabria, Rajan S Kombu, Guo-Fang Zhang, Yana Sandlers, Jizhou Ai, Rafael A Ibarra, Rime Abbas, Kush Goyal, Henri Brunengraber
BACKGROUND: The incidence of liver disease is increasing in USA. Animal models had shown glutathione species in plasma reflects liver glutathione state and it could be a surrogate for the detection of hepatocellular carcinoma (HCC). METHODS: The present study aimed to translate methods to the human and to explore the role of glutathione/metabolic prints in the progression of liver dysfunction and in the detection of HCC. Treated plasma from healthy subjects (n = 20), patients with liver disease (ESLD, n = 99) and patients after transplantation (LTx, n = 7) were analyzed by GC- or LC/MS...
December 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28326448/anaerobic-metabolism-in-t4-acanthamoeba-genotype
#3
Daniella de Sousa Mendes Moreira Alves, Luciano Moreira Alves, Tatiane Luiza da Costa, Ana Maria de Castro, Marina Clare Vinaud
Members of the genus Acanthamoeba are of the most common protozoa that has been isolated from a variety of environment and affect immunocompromised individuals, causing granulomatous amoebic encephalitis and skin lesions. Acanthamoeba, in immunocompetent patients, may cause a keratitis related to corneal microtrauma. These free-living amoebas easily adapt to the host environment and wield metabolic pathways such as the energetic and respiratory ones in order to maintain viability for long periods. The energetic metabolism of cysts and trophozoites remains mostly unknown...
March 22, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28322482/progressive-multifocal-leukoencephalopathy-associated-with-fumaric-acid-esters-treatment-in-psoriasis-patients
#4
Deepak M W Balak, Enes Hajdarbegovic, Wichor M Bramer, Martino H A Neumann, H Bing Thio
BACKGROUND: Fumaric acid esters (FAEs) are a systemic treatment for psoriasis considered to have a favorable long-term safety profile without an increased risk for immunosuppression. However, progressive multifocal leukoencephalopathy (PML), a rare, opportunistic viral infection of the central nervous system, has been linked anecdotally to FAE treatment. OBJECTIVE: to assess clinical features and outcomes of FAE-associated PML cases. METHODS: Systematic literature search in multiple databases up to February, 25(th) 2016 for reports of PML in psoriasis patients treated with FAEs...
March 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28317705/comparison-of-old-cherry-cultivars-grown-in-czech-republic-by-chemical-composition-and-bioactive-compounds
#5
Agnieszka Nawirska-Olszańska, Joanna Kolniak-Ostek, Maciej Oziembłowski, Alena Ticha, Radomir Hyšpler, Zdenek Zadak, Pavla Židová, Frantisek Paprstein
Sweet cherry fruits are readily consumed by humans, and they contain significant quantities of bioactive compounds. Fifteen sweet cherry (Prunus avium L.) old cultivars grown in the Czech Republic were examined. In fresh fruits the contents of sugars, organic acids, and phenolic compounds, and antioxidant capacity were determined. The analyses showed that the fruits of sweet cherry are characterized by high contents of bioactive compounds. Four organic acids - malic, quinic, shikimic, and fumaric acid - were determined in examined fruits...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28316081/the-antidiabetic-drug-metformin-decreases-mitochondrial-respiration-and-tricarboxylic-acid-cycle-activity-in-cultured-primary-rat-astrocytes
#6
Michaela C Hohnholt, Eva-Maria Blumrich, Helle S Waagepetersen, Ralf Dringen
Metformin is an antidiabetic drug that is used daily by millions of patients worldwide. Metformin is able to cross the blood-brain barrier and has recently been shown to increase glucose consumption and lactate release in cultured astrocytes. However, potential effects of metformin on mitochondrial tricarboxylic acid (TCA) cycle metabolism in astrocytes are unknown. We investigated this by mapping (13) C labeling in TCA cycle intermediates and corresponding amino acids after incubation of primary rat astrocytes with [U-(13) C]glucose...
March 19, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28292933/complete-elucidation-of-the-late-steps-of-bafilomycin-biosynthesis-in-streptomyces-lohii
#7
Zhong Li, Lei Du, Wei Zhang, Xingwang Zhang, Yuanyuan Jiang, Kun Liu, Ping Men, Huifang Xu, Jeffrey L Fortman, David H Sherman, Bing Yu, Song Gao, Shengying Li
Bafilomycins are an important subgroup of polyketides with diverse biological activities and possible applications as specific inhibitors of vacuolar H+-ATPase. However, the general toxicity and structural complexity of bafilomycins present formidable challenges to drug design via chemical modification, prompting interests in improving bafilomycin activities via biosynthetic approaches. Two bafilomycin biosynthetic gene clusters have been identified, but their post- polyketide synthase (PKS) tailoring steps for structural diversification and bioactivity improvement remain largely unknown...
March 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28290369/effect-of-different-iron-compounds-on-rheological-and-technological-parameters-as-well-as-bioaccessibility-of-minerals-in-whole-wheat-bread
#8
Ana Paula Rebellato, Jéssica Bussi, Joyce Grazielle Siqueira Silva, Ralf Greiner, Caroline Joy Steel, Juliana Azevedo Lima Pallone
This study aimed at investigating the effect of iron compounds used in whole wheat flour (WWF) fortification, both on rheological properties of the dough and on bread technological quality. Furthermore, bioaccessibility of iron (Fe), zinc (Zn) and calcium (Ca) in the final breads was determined. Rheological properties (mainly dough development time, stability, mixing tolerance index, resistance to extension and ratio number) of the dough and the technological quality of bread (mainly oven spring and cut opening) were altered...
April 2017: Food Research International
https://www.readbyqxmd.com/read/28289076/fumarate-mediates-a-chronic-proliferative-signal-in-fumarate-hydratase-inactivated-cancer-cells-by-increasing-transcription-and-translation-of-ferritin-genes
#9
Michael John Kerins, Ajay Vashisht, Benjamin Xi-Tong Liang, Spencer Jordan Duckworth, Brandon John Praslicka, James Akira Wohlschlegel, Aikseng Ooi
Germline mutations of the gene encoding the tricarboxylic acid cycle (TCA cycle) enzyme, fumarate hydratase (FH), cause a hereditary cancer syndrome known as hereditary leiomyomatosis and renal cell cancer (HLRCC). HLRCC associated tumors harbor biallelic FH inactivation that results in the accumulation of the TCA cycle metabolite, fumarate. Although it is known that the fumarate accumulation can alter cellular signaling, if and how fumarate confers a growth advantage remains unclear. Here we show that fumarate accumulation confers a chronic proliferative signal by disrupting cellular iron signaling...
March 13, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28288640/overexpression-of-a-c4-dicarboxylate-transporter-is-the-key-for-rerouting-citric-acid-to-c4-dicarboxylic-acid-production-in-aspergillus-carbonarius
#10
Lei Yang, Eleni Christakou, Jesper Vang, Mette Lübeck, Peter Stephensen Lübeck
BACKGROUND: C4-dicarboxylic acids, including malic acid, fumaric acid and succinic acid, are valuable organic acids that can be produced and secreted by a number of microorganisms. Previous studies on organic acid production by Aspergillus carbonarius, which is capable of producing high amounts of citric acid from varieties carbon sources, have revealed its potential as a fungal cell factory. Earlier attempts to reroute citric acid production into C4-dicarboxylic acids have been with limited success...
March 14, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28272219/predictive-value-of-serum-alt-and-t-cell-receptor-beta-variable-chain-for-hbeag-seroconversion-in-chronic-hepatitis-b-patients-during-tenofovir-treatment
#11
Jiezuan Yang, Dong Yan, Renyong Guo, Jiajia Chen, Yongtao Li, Jun Fan, Xuyan Fu, Xinsheng Yao, Hongyan Diao, Lanjuan Li
Effective antiviral therapy plays a key role in slowing the progression of chronic hepatitis B (CHB). Identification of serum indices, including hepatitis B e antigen (HBeAg) expression and seroconversion, will facilitate evaluation of the efficacy of antiviral therapy in HBeAg-positive CHB patients. The biochemical, serological, virological parameters, and the frequency of circulating CD4CD25 regulatory T cell (Treg) in 32 patients were measured at baseline and every 12 weeks during 96 weeks of tenofovir disoproxil fumarate (TDF) treatment...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28266022/an-artificial-tca-cycle-selects-for-efficient-%C3%AE-ketoglutarate-dependent-hydroxylase-catalysis-in-engineered-escherichia-coli
#12
Eleni Theodosiou, Marina Breisch, Mattijs K Julsing, Francesco Falcioni, Bruno Bühler, Andreas Schmid
Amino acid hydroxylases depend directly on the cellular TCA cycle via their cosubstrate a-ketoglutarate (α-KG) and are highly useful for the selective biocatalytic oxyfunctionalization of amino acids. This study evaluates TCA cycle engineering strategies to force and increase α-KG flux through proline-4-hydroxylase (P4H). The genes sucA (α-KG dehydrogenase E1 subunit) and sucC (succinyl-CoA synthetase β subunit) were alternately deleted together with aceA (isocitrate lyase) in proline degradation-deficient Escherichia coli strains (ΔputA) expressing the p4h gene...
March 7, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28258993/co-fermentation-of-a-mixture-of-glucose-and-xylose-to-fumaric-acid-by-rhizopus-arrhizus-rh-7-13-9
#13
Huan Liu, Huirong Hu, Yuhan Jin, Xuemin Yue, Li Deng, Fang Wang, Tianwei Tan
Lignocellulose is the most abundant biomass, composed of cellulose, hemicellulose and lignin. It can be converted into glucose and xylose, which could be utilized as carbon source to produce fumaric acid. But glucose and xylose were commonly used separately to produce fumaric acid, while the co-fermentation of glucose and xylose process was not studied so far. In this work, the co-fermentation process was researched through a new strain R. arrhizus RH 7-13-9# isolated from high concentration xylose. It was firstly proven to utilize glucose efficiently and 37...
February 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28258191/dimethyl-fumarate-selectively-reduces-memory-t-cells-and-shifts-the-balance-between-th1-th17-and-th2-in-multiple-sclerosis-patients
#14
Qi Wu, Qin Wang, Guangmei Mao, Catherine A Dowling, Steven K Lundy, Yang Mao-Draayer
Dimethyl fumarate (DMF; trade name Tecfidera) is an oral formulation of the fumaric acid ester that is Food and Drug Administration approved for treatment of relapsing-remitting multiple sclerosis. To better understand the therapeutic effects of Tecfidera and its rare side effect of progressive multifocal leukoencephalopathy, we conducted cross-sectional and longitudinal studies by immunophenotyping cells from peripheral blood (particularly T lymphocytes) derived from untreated and 4-6 and 18-26 mo Tecfidera-treated stable relapsing-remitting multiple sclerosis patients using multiparametric flow cytometry...
March 3, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28249717/design-of-simulated-moving-bed-for-separation-of-fumaric-acid-with-a-little-fronting-phenomenon
#15
Jae-Hwan Choi, Mun-Seok Kang, Chung-Gi Lee, Nien-Hwa Linda Wang, Sungyong Mun
The production of fumaric acid through a biotechnological pathway has grown in importance because of its potential value in related industries. This has sparked an interest in developing an economically-efficient process for separation of fumaric acid (product of interest) from acetic acid (by-product). This study aimed to develop a simulated moving bed (SMB) chromatographic process for such separation in a systematic way. As a first step for this work, commercially available adsorbents were screened for their applicability to the considered separation, which revealed that an Amberchrom-CG71C resin had a sufficient potential to become an adsorbent of the targeted SMB...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28249023/metabolic-changes-in-the-midgut-of-eri-silkworm-after-oral-administration-of-1-deoxynojirimycin-a-1h-nmr-based-metabonomic-study
#16
Ming-Jie Deng, Xiao-Dong Lin, Chao-Wei Wen, Min-Jian Dong, Qiu-Ting Lin, Shang-Zhi Zhang, Jia-Ping Xu
1-deoxynojirimycin (DNJ) is a natural D-glucose analogue and has a strong physiological activity in inhibiting α-glucosidase in vivo. The antidiabetic effects of DNJ in mice or other mammals were extensively explored, but the physiological and toxic roles of DNJ in insects was seldom reported. In this study, the biological effects of DNJ were examined in midgut extracts of fourth-instar larvae of Eri silkworm (Samia cynthia ricini, Saturniidae). Based on nuclear magnetic resonance (NMR) metabonomics technology, we analyzed the alterations of glycometabolism, lipids, and energy metabolism pathways in the midgut of S...
2017: PloS One
https://www.readbyqxmd.com/read/28244075/fumaric-acid-esters-a-new-therapeutic-option-for-skin-manifestations-in-lupus-erythematosus
#17
A Kuhn, A Landmann, G Bonsmann
No abstract text is available yet for this article.
February 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28219702/genetic-alterations-in-krebs-cycle-and-its-impact-on-cancer-pathogenesis
#18
REVIEW
Karishma Sajnani, Farhadul Islam, Robert Anthony Smith, Vinod Gopalan, Alfred King-Yin Lam
Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and energy metabolism. Glycolysis in non-oxygen condition is the main energy production process in cancer rather than mitochondrial respiration as in benign cells. Genetic and epigenetic alterations of Krebs cycle enzymes favour the shift of cancer cells from oxidative phosphorylation to anaerobic glycolysis. Mutations in genes encoding aconitase, isocitrate dehydrogenase, succinate dehydrogenase, fumarate hydratase, and citrate synthase are noted in many cancers...
April 2017: Biochimie
https://www.readbyqxmd.com/read/28219662/fumarase-deficiency-causes-protein-and-metabolite-succination-and-intoxicates-mycobacterium-tuberculosis
#19
Nadine Ruecker, Robert Jansen, Carolina Trujillo, Susan Puckett, Pradeepa Jayachandran, Gerardo G Piroli, Norma Frizzell, Henrik Molina, Kyu Y Rhee, Sabine Ehrt
Enzymes of central carbon metabolism are essential mediators of Mycobacterium tuberculosis (Mtb) physiology and pathogenicity, but are often perceived to lack sufficient species selectivity to be pursued as potential drug targets. Fumarase (Fum) is an enzyme of the canonical tricarboxylic acid cycle and is dispensable in many organisms. Transposon mutagenesis studies in Mtb, however, indicate that Fum is required for optimal growth. Here, we report the generation and characterization of a genetically engineered Mtb strain in which Fum expression is conditionally regulated...
March 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28216384/novel-homozygous-pck1-mutation-causing-cytosolic-phosphoenolpyruvate-carboxykinase-deficiency-presenting-as-childhood-hypoglycemia-an-abnormal-pattern-of-urine-metabolites-and-liver-dysfunction
#20
Päivi Vieira, Jessie Cameron, Elisa Rahikkala, Riikka Keski-Filppula, Lin-Hua Zhang, Saikat Santra, Allison Matthews, Päivi Myllynen, Matti Nuutinen, Jukka S Moilanen, Richard J Rodenburg, Arndt Rolfs, Johanna Uusimaa, Clara D M van Karnebeek
Clinical and laboratory data were collected from three Finnish patients including a sibling pair and another unrelated child with unexplained childhood hypoglycemia. Transient elevation of alanine transaminase, lactate and tricarboxylic acid cycle intermediates, especially fumarate, were noticed in urine organic acid analysis. Exome sequencing was performed for the patients and their parents. A novel homozygous PCK1 c.925G>A (p.G309R) mutation was detected in all affected individuals. COS-1 cells transfected with mutant PCK1 transcripts were used to study the pathogenic nature of the detected variant...
February 6, 2017: Molecular Genetics and Metabolism
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