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fumaric acid

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https://www.readbyqxmd.com/read/28928899/hyperpolarized-13-c-diffusion-mrs-of-co-polarized-pyruvate-and-fumarate-to-measure-lactate-export-and-necrosis
#1
Benedikt Feuerecker, Markus Durst, Michael Michalik, Günter Schneider, Dieter Saur, Marion Menzel, Markus Schwaiger, Franz Schilling
Background: Non-invasive tumor characterization and monitoring are among the key goals of medical imaging. Using hyperpolarized (13)C-labelled metabolic probes fast metabolic pathways can be probed in real-time, providing new opportunities for tumor characterization. In this in vitro study, we investigated whether measurement of apparent diffusion coefficient (ADC) measurements and magnetic resonance spectroscopy (MRS) of co-polarized (13)C-labeled pyruvic acid and fumaric acid can non-invasively detect both necrosis and changes in lactate export, which are parameters indicative of tumor aggressiveness...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28910859/investigation-of-the-effects-of-storage-and-freezing-on-mixes-of-heavy-labeled-metabolite-and-amino-acid-standards
#2
Rachel Culp-Hill, Julie A Reisz, Kirk C Hansen, Angelo D'Alessandro
RATIONALE: High-throughput metabolomics has now made it possible for small/medium-sized laboratories to analyze thousands of samples/year from the most diverse biological matrices including biofluids, cell and tissue extracts. In large scale metabolomics studies, stable isotope-labeled standards are increasingly used to normalize for matrix effects and control for technical reproducibility (e.g. extraction efficiency, chromatographic retention times and mass spectrometry signal stability)...
September 14, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28903160/safety-of-systemic-agents-for-the-treatment-of-pediatric-psoriasis
#3
Inge M G J Bronckers, Marieke M B Seyger, Dennis P West, Irene Lara-Corrales, Megha Tollefson, Wynnis L Tom, Marcia Hogeling, Leah Belazarian, Claus Zachariae, Emmanuel Mahé, Elaine Siegfried, Sandra Philipp, Zsuzsanna Szalai, Ruth Ann Vleugels, Kristen Holland, Ruth Murphy, Eulalia Baselga, Kelly Cordoro, Jo Lambert, Alex Alexopoulos, Ulrich Mrowietz, Wietske Kievit, Amy S Paller
Importance: Use of systemic therapies for moderate to severe psoriasis in children is increasing, but comparative data on their use and toxicities are limited. Objective: To assess patterns of use and relative risks of systemic agents for moderate to severe psoriasis in children. Design, Setting, and Participants: A retrospective review was conducted at 20 centers in North America and Europe, and included all consecutive children with moderate to severe psoriasis who used systemic medications or phototherapy for at least 3 months from December 1, 1990, to September 16, 2014...
September 13, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28899959/impaired-malate-and-fumarate-accumulation-due-the-mutation-of-tonoplast-dicarboxylate-transporter
#4
David B Medeiros, Kallyne Barros, Jessica As Barros, Rebeca P Omena-Garcia, Stéphanie Arrivault, Lilian Vincis Pereira Sanglard, Kelly C Detmann, Willian Batista Silva, Danilo M Daloso, Fabio DaMatta, Adriano Nunes-Nesi, Alisdair R Fernie, Wagner L Araújo
Malate is a central metabolite involved in a multiplicity of plant metabolic pathways, being associated with mitochondrial metabolism and playing significant roles in stomatal movements. Vacuolar malate transport has been characterized at the molecular level and is performed by at least one carrier protein and two channels in Arabidopsis vacuoles. The absence of the Arabidopsis thaliana tonoplast Dicarboxylate Transporter (tDT) in tdt knockout mutant was previously associated with an impaired accumulation of malate and fumarate in leaves...
September 12, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28898541/biologics-combined-with-conventional-systemic-agents-or-phototherapy-for-the-treatment-of-psoriasis-real-life-data-from-psonet-registries
#5
C I Busard, A D Cohen, P Wolf, S Gkalpakiotis, S Cazzaniga, R S Stern, B A Hutten, I Feldhamer, F Quehenberger, R Lichem, M Kojanova, E Adenubiova, A Addis, L Naldi, P I Spuls
BACKGROUND: Biologics have greatly improved psoriasis management. However, primary and secondary non-response to treatment requires innovative strategies to optimize outcomes. OBJECTIVE: To describe the use of combined treatment of biologics with conventional systemic agents or phototherapy in daily clinical practice. METHODS: We collected data on frequency of use, demographics, treatment characteristics and drug survival of biologics combined with conventional systemic agents or phototherapy in five PSONET registries...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28893364/petrothermobacter-organivorans-gen-nov-sp-nov-a-thermophilic-strictly-anaerobic-bacterium-of-the-phylum-deferribacteres-isolated-from-a-deep-subsurface-oil-reservoir
#6
Satoshi Tamazawa, Daisuke Mayumi, Hanako Mochimaru, Susumu Sakata, Haruo Maeda, Tatsuki Wakayama, Masayuki Ikarashi, Yoichi Kamagata, Hideyuki Tamaki
A novel thermophilic, anaerobic, chemoheterotrophic, acetate-oxidizing and iron(III)-, manganese(IV)-, nitrate- and sulfate-reducing bacterium, designated strain ANAT, was isolated from a deep subsurface oil field in Japan (Yabase oil field, Akita Pref.). Cells of strain ANAT were Gram-stain-negative, non-motile, non-spore forming and slightly curved or twisted rods (1.5-5.0 µm long and 0.6-0.7 µm wide). The isolate grew at 25-60 °C (optimum 55 °C) and pH 6.0-8.0 (optimum pH 7.0). The isolate was capable of reducing iron(III), manganese(IV), nitrate and sulfate as an electron acceptor...
September 12, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28884964/anion-%C3%AF-catalysis-of-diels-alder-reactions
#7
Le Liu, Yoann Cotelle, Anna-Bea Bornhof, Céline Besnard, Naomi Sakai, Stefan Matile
Among concerted cycloadditions, the Diels-Alder reaction is the grand old classic, which is usually achieved with acid catalysis. In this report, hydroxypyrones, oxa-, and thiazolones are explored because they provide access to anionic dienes. Their [4+2] cycloaddition with cyclic and acyclic dienophiles, such as maleimides and fumarates, affords bicyclic products with four new stereogenic centers. Bifunctional anion-π catalysts composed of amine bases next to the π surface of naphthalenediimides (NDIs) are shown to selectively stabilize the "open", fully accessible anionic exo transition state on the π-acidic aromatic surface...
September 8, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28873360/bioanalysis-of-monomethyl-fumarate-in-human-plasma-by-a-sensitive-and-rapid-lc-ms-ms-method-and-its-pharmacokinetic-application-lc-ms-ms-determination-of-monomethyl-fumarate-in-human-plasma
#8
Imam Pasha S, Murali Balaram Varanasi, Ibrahim Mohammed
Dimethyl fumarate (DMF) is the methyl ester of fumaric acid, after oral administration completely converts to its active metabolite monomethyl fumarate (MMF). A simple, rapid and sensitive LC-MS/MS method was developed and validated for the quantification of MMF in human plasma. Monomethyl fumarate d3 was used as an internal standard (IS). The analyte and the IS were extracted from plasma using a selective solid phase extraction technique. The clean samples were chromatographed on a C18 column using formic acid and acetonitrile (25:75, v/v) as mobile phase...
August 23, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28870693/therapeutic-targeting-of-taz-and-yap-by-dimethyl-fumarate-in-systemic-sclerosis-fibrosis
#9
Tetsuo Toyama, Agnieszka P Looney, Brendon M Baker, Lukasz Stawski, Paul Haines, Robert Simms, Aleksander D Szymaniak, Xaralabos Varelas, Maria Trojanowska
Systemic sclerosis (scleroderma, SSc) is a devastating fibrotic disease with few treatment options. Fumaric acid esters, including dimethyl fumarate (DMF, Tecfidera®) have shown therapeutic effects in several disease models, prompting us to determine whether DMF is effective as a treatment for SSc dermal fibrosis. We found that DMF blocks the pro-fibrotic effects of TGFβ in SSc skin fibroblasts. Mechanistically, we found that DMF treatment reduced nuclear localization of TAZ and YAP proteins via inhibition of PI3-K/Akt1 pathway...
September 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28869956/the-implications-of-recent-recommendations-for-managing-patients-with-psoriasis-treated-with-fumaric-acid-esters
#10
Catherine C Foley, Oonagh E Molloy, Aoife Lally, Brian Kirby
BACKGROUND/AIMS: Fumaric acid esters (FAEs) are a well-established efficacious systemic treatment for psoriasis. Recent recommendations from the European Medicines Agency suggest monitoring of full blood count every 4 weeks for the duration of therapy for psoriasis. The aim of our study was to assess the incidence of lymphopenia in patients taking FAEs and the impact of recent recommendations for our practice. METHODS: We reviewed 151 patients treated with FAEs for psoriasis between December 2013 and 2015...
September 5, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28868653/metabonomic-analysis-of-serum-reveals-antifatigue-effects-of-yi-guan-jian-on-fatigue-mice-using-gas-chromatography-coupled-to-mass-spectrometry
#11
Sufang Shui, Xiaorong Cai, Rongqing Huang, Bingkun Xiao, Jianyun Yang
Yi Guan Jian (YGJ), one of the most commonly used traditional Chinese medicines (TCM), has been reported to possess significant antifatigue effects in the eastern. However, the mechanisms underlying its antifatigue effects remain largely unresolved. In this study, a metabonomics approach, involving gas chromatography coupled to mass spectrometry (GC/MS) and a multivariate statistical technique, was developed to estimate the extent to which YGJ alleviated the exhausting swimming induced fatigue of mice. High dose treatment with YGJ significantly extended the swimming time of fatigued mice...
September 3, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28867000/desulfovibrio-senegalensis-sp-nov-a-mesophilic-sulfate-reducer-isolated-from-marine-sediment
#12
Abdoulaye Thioye, Zouhaier Ben Ali Gam, Malick Mbengue, Jean-Luc Cayol, Manon Joseph-Bartoli, Coumba Touré-Kane, Marc Labat
Several strains of sulfate-reducing bacteria were isolated from marine sediments recovered from Hann Bay (Senegal). All were related to members of the genus Desulfovibrio. A strictly anaerobic, mesophilic and moderately halophilic strain designated BLaC1T was further characterized. Cells of strain BLaC1T stained Gram-negative and were 0.5 µm wide and 2-4 µm long, motile, rod-shaped and non-spore-forming. The four major fatty acids were anteiso-C15 : 0, iso-C15 : 0, iso-C17 : 0 and anteiso-C17 : 0...
September 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28866798/development-of-an-amperometric-biosensor-platform-for-the-combined-determination-of-l-malic-fumaric-and-l-aspartic-acid
#13
Désirée L Röhlen, Johanna Pilas, Michael J Schöning, Thorsten Selmer
Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD(+)) and the redox mediator hexacyanoferrate (III) (HCFIII)...
September 2, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28861402/ixodes-scapularis-tick-cells-control-anaplasma-phagocytophilum-infection-by-increasing-the-synthesis-of-phosphoenolpyruvate-from-tyrosine
#14
Alejandro Cabezas-Cruz, Pedro J Espinosa, Dasiel A Obregón, Pilar Alberdi, José de la Fuente
The obligate intracellular pathogen, Anaplasma phagocytophilum, is the causative agent of life-threatening diseases in humans and animals. A. phagocytophilum is an emerging tick-borne pathogen in the United States, Europe, Africa and Asia, with increasing numbers of infected people and animals every year. It is increasingly recognized that intracellular pathogens modify host cell metabolic pathways to increase infection and transmission in both vertebrate and invertebrate hosts. Recent reports have shown that amino acids are central to the host-pathogen metabolic interaction...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28847082/production-of-fumaric-acid-by-immobilized-rhizopus-arrhizus-rh-7-13-9-on-loofah-fiber-in-a-stirred-tank-reactor
#15
Huan Liu, Shijie Zhao, Yuhan Jin, Xuemin Yue, Li Deng, Fang Wang, Tianwei Tan
Fumaric acid is an important building-block chemical. The production of fumaric acid by fermentation is possible. Loofah fiber is a natural, biodegradable, renewable polymer material with highly sophisticated and pore structure. This work investigated a new immobilization method using loofah fiber as carrier to produce fumaric acid in a stirred-tank reactor. Compared with other carriers, loofah fiber was proven to be efficiently and successfully used in the reactor. After the optimization process, 20g addition of loofah fiber and 400rpm agitation speed were chosen as the most suitable process conditions...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28846986/chemical-characteristics-of-dicarboxylic-acids-and-related-organic-compounds-in-pm2-5-during-biomass-burning-and-non-biomass-burning-seasons-at-a-rural-site-of-northeast-china
#16
Fang Cao, Shi-Chun Zhang, Kimitaka Kawamura, Xiaoyan Liu, Chi Yang, Zufei Xu, Meiyi Fan, Wenqi Zhang, Mengying Bao, Yunhua Chang, Wenhuai Song, Shoudong Liu, Xuhui Lee, Jun Li, Gan Zhang, Yan-Lin Zhang
Fine particulate matter (PM2.5) samples were collected using a high-volume air sampler and pre-combusted quartz filters during May 2013 to January 2014 at a background rural site (47(∘)35 N, 133(∘)31 E) in Sanjiang Plain, Northeast China. A homologous series of dicarboxylic acids (C2-C11) and related compounds (oxoacids, α-dicarbonyls and fatty acids) were analyzed by using a gas chromatography (GC) and GC-MS method employing a dibutyl ester derivatization technique. Intensively open biomass-burning (BB) episodes during the harvest season in fall were characterized by high mass concentrations of PM2...
August 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28846033/metabolic-alterations-of-qinghai-tibet-plateau-pikas-in-adaptation-to-high-altitude
#17
Xue-Feng Cao, Zhen-Zhong Bai, Lan Ma, Shuang Ma, Ri-Li Ge
Cao, Xue-Feng, Zhen-Zhong Bai, Lan Ma, Shuang Ma, and Ri-Li Ge. Metabolic alterations of Qinghai-Tibet plateau pikas in adaptation to high altitude. High Alt Med Biol. 18:219-225, 2017.-To determine specific metabolic alterations in the myocardium of plateau pikas (Ochotona curzoniae) and potential metabolic biomarkers involved in their adaptation to the high-altitude environment of the Qinghai-Tibet Plateau. Ten pikas were captured by traps in the Kekexili Reserve (4630 m a.s.l; n = 5) and at the foot of the Laji Mountain (2600 m a...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28845931/-adjuvant-antioxidant-therapy-in-varicocele-infertility
#18
S I Gamidov, R I Ovchinnikov, A Yu Popova, A Yu Avakyan, G T Sukhikh
INTRODUCTION: Infertility affects an estimated 15% of couples globally. Male factor infertility accounts for about a half of infertility cases. About 40% of infertile men have varicocele. The aim of this study was to investigate the efficacy and safety of a complex of acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (SpermActin-forte) (SA) for adjuvant antioxidant therapy after microsurgical varicocelectomy (MVE) in men with varicocele and assess its impact on the level of DNA fragmentation in sperm cells...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28827149/studies-on-the-interaction-of-the-histone-demethylase-kdm5b-with-tricarboxylic-acid-cycle-intermediates
#19
Hanna Tarhonskaya, Radoslaw P Nowak, Catrine Johansson, Aleksandra Szykowska, Anthony Tumber, Rebecca L Hancock, Pauline Lang, Emily Flashman, Udo Oppermann, Christopher J Schofield, Akane Kawamura
Methylation of lysine-4 of histone H3 (H3K4men) is an important regulatory factor in eukaryotic transcription. Removal of the transcriptionally activating H3K4 methylation is catalyzed by histone demethylases, including the Jumonji C (JmjC) KDM5 subfamily. The JmjC KDMs are Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenases, some of which are associated with cancer. Altered levels of tricarboxylic acid (TCA) cycle intermediates and the associated metabolites D- and L-2-hydroxyglutarate (2HG) can cause changes in chromatin methylation status...
August 18, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28818756/interactions-between-aluminium-iron-and-silicon-in-cucumber-sativus-l-grown-under-acidic-conditions
#20
Nikolai P Bityutskii, Kirill L Yakkonen, Anastasiya I Petrova, Alexey L Shavarda
Aluminium (Al) is one of the major stressors for plants in acidic soils, negatively affecting plant growth and nutrient balances. Significant efforts have been undertaken to understand mechanisms of Al tolerance in plants. However, little is known of the relevance of iron (Fe) and silicon (Si) nutrition under Al stress conditions. The objectives of this study were to determine whether effects induced by Fe and Si are of importance for limitation of Al moving via xylem in plants (Cucumis sativus L.). Cucumber plants (cv...
August 4, 2017: Journal of Plant Physiology
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