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https://www.readbyqxmd.com/read/29288231/sulforaphane-modifies-histone-h3-unpacks-chromatin-and-primes-defense
#1
Britta Schillheim, Irina Jansen, Stephani Baum, Carsten Bolm, Alexander Beesley, Uwe Conrath
Modern crop production calls for agrochemicals that prime plants for enhanced defense. Reliable test systems for spotting priming-inducing chemistry, however, are rare. We developed an assay for the high-throughput search for compounds that prime microbial pattern-induced secretion of antimicrobial furanocoumarins (phytoalexins) in cultured parsley cells. The screen produced 1-isothiocyanato-4-methylsulfinylbutane (sulforaphane; SFN), a secondary metabolite in many crucifers, as a novel defense priming compound...
December 29, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29247770/apigenin-promotes-trail-mediated-apoptosis-regardless-of-ros-generation
#2
Chang-Hee Kang, Ilandarage Menu Neelaka Molagoda, Yung Hyun Choi, Cheol Park, Dong-Oh Moon, Gi-Young Kim
Apigenin is a bioactive flavone in several herbs including parsley, thyme, and peppermint. Apigenin possesses anti-cancer and anti-inflammatory properties; however, whether apigenin enhances TRAIL-mediated apoptosis in cancer cells is unknown. In the current study, we found that apigenin enhanced TRAIL-induced apoptosis by promoting caspase activation and death receptor 5 (DR5) expression and a chimeric antibody against DR5 completely blocked the apoptosis. Apigenin also upregulated reactive oxygen species (ROS) generation; however, intriguingly, ROS inhibitors, glutathione (GSH) or N-acetyl-l-cysteine (NAC), moderately increased apigenin/TRAIL-induced apoptosis...
December 13, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29211364/insights-into-novel-anticancer-applications-for-apigenin
#3
REVIEW
Adam Kowalczyk, Agnieszka Bodalska, Marta Miranowicz, Katarzyna Karłowicz-Bodalska
Flavonoids, naturally occuring derivatives of 2-phenyl-benzo-γ-pyrone, are widespread in plants as coloring substances. Apigenin (4',5,7,-trihydroxyflavone (5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one), molecular formula C₁₅H₁₀O⁵, is a flavonoid present in many fruits and vegetables, primarily in citrus fruits, apples, parsley and celery leaves. It is also found in some medicinal plants, including chamomile flowers, thyme, oregano, peppermint, lemon balm and yarrow, as a 7-O-glycoside with anti-inflammatory and antioxidant activity...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29181438/parsley-mechanism-as-antiurolithiasis-remedy
#4
Fayed Al-Yousofy, Hussein Gumaih, Hassan Ibrahim, Afrah Alasbahy
Parsley is a medicinal plant used widely in urolithiasis. The present study aimed to evaluate the antiurolithiatic effect of parsley and its mechanism. 24 rats divided into four groups: group A (negative control), group B (positive control), group C (cystone® group) and group D (parsley group). Group B were treated with EG and Ammonium chloride (AC). Group C were treated as B plus cystone® and group D was treated as B plus parsley. The period of experiment was 15 days. Urine samples were analysis on days 0 and 15 days...
2017: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29160141/effects-of-mild-blast-traumatic-brain-injury-on-cerebral-vascular-histopathological-and-behavioral-outcomes-in-rats
#5
Uylissa A Rodriguez, Yaping Zeng, Donald James Deyo, Margaret O Parsley, Bridget E Hawkins, Donald S Prough, Douglas DeWitt
To determine the effects of mild blast-induced traumatic brain injury (bTBI), several groups of rats were subjected to blast injury or sham injury in a compressed air-driven shock tube. The effects of bTBI on relative cerebral perfusion (laser Doppler flowmetry, LDF), mean arterial blood pressure (MAP) cerebral vascular resistance were measured for two hrs post-bTBI. Dilator responses to reduced intravascular pressure were measured in isolated middle cerebral arterial (MCA) segments, ex vivo, 30 and 60 min post-bTBI...
November 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29125626/impact-of-air-frying-on-cholesterol-and-fatty-acids-oxidation-in-sardines-protective-effects-of-aromatic-herbs
#6
Fernanda S Ferreira, Geni R Sampaio, Laura M Keller, Alexandra C H F Sawaya, Davy W H Chávez, Elizabeth A F S Torres, Tatiana Saldanha
The high temperatures used to fry fish may induce thermo-oxidation of cholesterol, forming cholesterol oxidation products (COPs). COPs have been associated to coronary heart diseases, atherosclerosis, and other chronic diseases. Air fryers are an alternative thermal process technology to fry foods without oil, and are considered a healthier cooking method. This study is the 1st to evaluate the formation of COPs and the degradation of polyunsaturated fatty acids (PUFAs) in air-fried sardine fillets. Furthermore, we evaluated the effect of fresh herbs added as natural antioxidants to sardines subjected to air frying...
November 10, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29108230/apigenin-enhances-skeletal-muscle-hypertrophy-and-myoblast-differentiation-by-regulating-prmt7
#7
Young Jin Jang, Hyo Jeong Son, Yong Min Choi, Jiyun Ahn, Chang Hwa Jung, Tae Youl Ha
Apigenin, a natural flavone abundant in various plant-derived foods including parsley and celery, has been shown to prevent inflammation and inflammatory diseases. However, the effect of apigenin on skeletal muscle hypertrophy and myogenic differentiation has not previously been elucidated. Here, we investigated the effects of apigenin on quadricep muscle weight and running distance using C57BL/6 mice on an accelerating treadmill. Apigenin stimulated mRNA expression of MHC (myosin heavy chain) 1, MHC2A, and MHC2B in the quadricep muscles of these animals...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29094044/comparison-between-the-hypolipidemic-activity-of-parsley-and-carob-in-hypercholesterolemic-male-rats
#8
Haddad A El Rabey, Madeha N Al-Seeni, Habibah B Al-Ghamdi
Hypercholesterolemia is commonly associated with obesity that leads to heart diseases and diabetes. The hepatocardioprotective activity of parsley and carob methanol extract was tested in hypercholesterolemic male rats. Twenty-four male albino rats were divided into four groups (n = 6). Group 1 was the negative control group fed with fat rich diet, group 2 (G2) was hypercholesterolemic rats fed with fat rich diet with 2% cholesterol, and group 3 and group 4 (G3 and G4) were hypercholesterolemic rats supplemented with 2% cholesterol and cotreated with 20% w/w parsley seed methanol extract and 20% w/w carob legume methanol extract, respectively...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29084156/the-dietary-furocoumarin-imperatorin-increases-plasma-glp-1-levels-in-type-1-like-diabetic-rats
#9
Lin-Yu Wang, Kai-Chun Cheng, Yingxiao Li, Chiang-Shan Niu, Juei-Tang Cheng, Ho-Shan Niu
Imperatorin, a dietary furocoumarin, is found not only in medicinal plants, but also in popular culinary herbs, such as parsley and fennel. Recently, imperatorin has been shown to activate GPR119 in cells. Another GPR, GPR131, also called TGR5 or G-protein-coupled bile acid receptor 1 (GPBAR1), is known to regulate glucose metabolism. Additionally, TGR5 activation increases glucagon-like peptide (GLP-1) secretion to lower blood sugar levels in animals. Therefore, the present study aims to determine whether the effects of imperatorin on GLP-1 secretion are mediated by TGR5...
October 30, 2017: Nutrients
https://www.readbyqxmd.com/read/29054139/mc-media-pad-acplus%C3%A2-for-enumeration-of-aerobic-counts-in-a-variety-of-foods
#10
Hajime Teramura, Gail Betts
The MC-Media Pad ACplus™ is a dry, rehydratable film medium for the enumeration of aerobic bacterial colonies.The performance of the method in a variety of foods was compared to that of U.S. reference methods: U.S. Department of Agriculture (USDA) Food Safety and Inspection Service (FSIS) Microbiology Laboratory Guidebook (MLG) Chapter 3.02 "Quantitative Analysis of Bacteria in Foods as Sanitary Indicators" (USDA/FSIS MLG 3.02); Standard Methods for the Examination of Dairy Products (SMEDP) Chapter 6 "Microbiological Count Methods, Standard Plate Count Method" (SMEDP 6); AOAC Official Method(SM)966...
October 20, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29016640/effects-of-aav-mediated-knockdown-of-nnos-and-gpx-1-gene-expression-in-rat-hippocampus-after-traumatic-brain-injury
#11
Deborah R Boone, Jeanna M Leek, Michael T Falduto, Karen E O Torres, Stacy L Sell, Margaret A Parsley, Jeremy C Cowart, Tatsuo Uchida, Maria-Adelaide Micci, Douglas S DeWitt, Donald S Prough, Helen L Hellmich
Virally mediated RNA interference (RNAi) to knock down injury-induced genes could improve functional outcome after traumatic brain injury (TBI); however, little is known about the consequences of gene knockdown on downstream cell signaling pathways and how RNAi influences neurodegeneration and behavior. Here, we assessed the effects of adeno-associated virus (AAV) siRNA vectors that target two genes with opposing roles in TBI pathogenesis: the allegedly detrimental neuronal nitric oxide synthase (nNOS) and the potentially protective glutathione peroxidase 1 (GPx-1)...
2017: PloS One
https://www.readbyqxmd.com/read/28981163/reduction-of-androstenone-perception-in-pan-fried-boar-meat-by-different-masking-strategies
#12
Macarena Egea, Mª Belén Linares, Marta Gil, Mª Belén López, Mª Dolores Garrido
BACKGROUND: Consumers highly sensitive to androstenone will probably reject meat from entire male pigs, which tends to have high levels of this hormone. To avoid this, the effect of different masking strategies (sprinkling with mixed spices or fennel, marinating and breading with garlic-parsley or curry) on the sensory parameters of pork loin chops obtained from entire animals with high levels of androstenone (AND) (1.0-2.9 mg kg (-1) AND in fat) and castrated animals (<0.4 mg kg (-1) AND in fat), both with low levels of skatole (SKA) (<0...
October 5, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28934070/presence-of-trihalomethanes-in-ready-to-eat-vegetables-disinfected-with-chlorine
#13
Valentina Coroneo, Valentina Carraro, Barbara Marras, Alessandro Marrucci, Sara Succa, Barbara Meloni, Antonella Pinna, Alberto Angioni, Adriana Sanna, Marco Schintu
Trihalomethanes (THMs) - CHCl3, CHCl2Br, CHClBr2 and CHBr3 - are drinking water disinfection by-products (DBPs). These compounds can also be absorbed by different types of foods, including ready-to-eat (RTE) fresh vegetables. The potential absorption of THMs during washing of RTE vegetables could pose a potential risk to consumers' health. The concentration of THMs in the water used in the manufacturing process of these products shall not exceed the limit of 100 or 80 µgL(-1) according to European Union (EU) and United States legislation, respectively...
October 11, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28911683/antibacterial-activity-and-interactions-of-plant-essential-oil-combinations-against-gram-positive-and-gram-negative-bacteria
#14
Cristina Anamaria Semeniuc, Carmen Rodica Pop, Ancuţa Mihaela Rotar
The aim of this study was to compare the antibacterial effects of several essential oils (EOs) alone and in combination against different Gram-positive and Gram-negative bacteria associated with food products. Parsley, lovage, basil, and thyme EOs, as well as their mixtures (1:1, v/v), were tested against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Salmonella typhimurium. The inhibitory effects ranged from strong (thyme EO against E. coli) to no inhibition (parsley EO against P...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28873566/selected-chemical-composition-changes-in-microwave-convective-dried-parsley-leaves-affected-by-ultrasound-and-steaming-pre-treatments-an-optimization-approach
#15
Magdalena Dadan, Katarzyna Rybak, Artur Wiktor, Malgorzata Nowacka, Joanna Zubernik, Dorota Witrowa-Rajchert
Parsley leaves contain a high amount of bioactive components (especially lutein), therefore it is crucial to select the most appropriate pre-treatment and drying conditions, in order to obtain high quality of dried leaves, which was the aim of this study. The optimization was done using response surface methodology (RSM) for the following factors: microwave power (100, 200, 300W), air temperature (20, 30, 40°C) and pre-treatment variant (ultrasound, steaming and dipping as a control). Total phenolic content (TPC), antioxidant activity, chlorophyll and lutein contents (using UPLC-PDA) were determined in dried leaves...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28856356/patient-preference-before-and-after-arthroscopic-rotator-cuff-repair-which-is-more-important-pain-relief-or-strength-return
#16
Mandeep S Virk, David M Levy, Benjamin D Kuhns, James S Krecher, Billy K Parsley, Stephen S Burkhart, Anthony A Romeo, Nikhil N Verma, Brian J Cole
Our understanding of patients' desired outcomes and expectations of arthroscopic rotator cuff repair (ARCR) is limited, particularly regarding the importance of pain relief and strength return relative to each other. We conducted a study of patient's ratings of the importance of pain relief and strength return after ARCR. Before undergoing surgery, 60 patients completed a shoulder questionnaire on which they assessed severity of symptoms and rated, on a 10-point scale, the importance of postoperative improvements in pain relief and strength return...
July 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28762945/structural-dynamics-of-rbma-governs-plasticity-of-vibrio-cholerae-biofilms
#17
Jiunn Cn Fong, Andrew Rogers, Alicia K Michael, Nicole C Parsley, William-Cole Cornell, Yu-Cheng Lin, Praveen K Singh, Raimo Hartmann, Knut Drescher, Evgeny Vinogradov, Lars Ep Dietrich, Carrie L Partch, Fitnat H Yildiz
Biofilm formation is critical for the infection cycle of Vibrio cholerae. Vibrio exopolysaccharides (VPS) and the matrix proteins RbmA, Bap1 and RbmC are required for the development of biofilm architecture. We demonstrate that RbmA binds VPS directly and uses a binary structural switch within its first fibronectin type III (FnIII-1) domain to control RbmA structural dynamics and the formation of VPS-dependent higher-order structures. The structural switch in FnIII-1 regulates interactions in trans with the FnIII-2 domain, leading to open (monomeric) or closed (dimeric) interfaces...
August 1, 2017: ELife
https://www.readbyqxmd.com/read/28745361/in-silico-genotoxicity-of-coumarins-application-of-the-phenol-explorer-food-database-to-functional-food-science
#18
E Guardado Yordi, M J Matos, A Pérez Martínez, A C Tornes, L Santana, E Molina, E Uriarte
Coumarins are a group of phytochemicals that may be beneficial or harmful to health depending on their type and dosage and the matrix that contains them. Some of these compounds have been proven to display pro-oxidant and clastogenic activities. Therefore, in the current work, we have studied the coumarins that are present in food sources extracted from the Phenol-Explorer database in order to predict their clastogenic activity and identify the structure-activity relationships and genotoxic structural alerts using alternative methods in the field of computational toxicology...
August 1, 2017: Food & Function
https://www.readbyqxmd.com/read/28657161/unambiguous-regiochemical-assignment-of-sulfoquinovosyl-mono-and-di-acylglycerols-in-parsley-and-spinach-leaves-by-liquid-chromatography-electrospray-ionization-sequential-mass-spectrometry-assisted-by-regioselective-enzymatic-hydrolysis
#19
Sara Granafei, Ilario Losito, Francesco Palmisano, Tommaso R I Cataldi
RATIONALE: Sulfoquinovosylmonoglycerides (SQMG) and sulfoquinovosyldiglycerides (SQDG) in the lipid extracts of parsley (Petroselinum crispum) and spinach (Spinacia oleracea) leaves were investigated. The aim of this work was to assess and establish the chemical characterization of fatty acyl chains in sulfolipids (SQMG and SQDG) and their regiochemistry. METHODS: A key component of this approach is a combination of hydrolysis reactions catalyzed by Lecitase® Ultra, which is a sn1 -regioselective hydrolase enzyme, and reversed-phase liquid chromatography with electrospray ionization and sequential mass spectrometry (RPLC-ESI-MS) by collision induced dissociation (CID)-MS(n) (n=2,3)...
June 28, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28646670/a-metagenomic-assessment-of-viral-contamination-on-fresh-parsley-plants-irrigated-with-fecally-tainted-river-water
#20
X Fernandez-Cassi, N Timoneda, E Gonzales-Gustavson, J F Abril, S Bofill-Mas, R Girones
Microbial food-borne diseases are still frequently reported despite the implementation of microbial quality legislation to improve food safety. Among all the microbial agents, viruses are the most important causative agents of food-borne outbreaks. The development and application of a new generation of sequencing techniques to test for viral contaminants in fresh produce is an unexplored field that allows for the study of the viral populations that might be transmitted by the fecal-oral route through the consumption of contaminated food...
June 21, 2017: International Journal of Food Microbiology
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