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Keri Donaldson, Laurence Demers, Kirk Taylor, Joe Lopez, Sherman Chang
Over 116 million people worldwide have chronic pain and prescription dependence. In the US, opioids account for the majority of overdose deaths, and in 2014, almost 2 million Americans abused or were dependent on prescription opioids. Genetic factors may play a key role in opioid prescription addiction. Herein, we describe genetic variations between opioid addicted and non-addicted populations and derive a predictive model determining risk of opioid addiction. This case cohort study compares the frequency of 16 single nucleotide polymorphisms involved in the brain reward pathways in patients with and without opioid addiction...
August 2017: Annals of Clinical and Laboratory Science
Sara Nicodemi, Sergio Corelli, Marco Sacchi, Edoardo Ricciardi, Annarita Costantino, Pietro Di Legge, Francesco Ceci, Benedetta Cipriani, Annunziata Martellucci, Mario Santilli, Silvia Orsini, Antonella Tudisco, Franco Stagnitti
Surgical wounds dehiscence is a serious post-operatory complication, with an incidence between 0.4% and 3.5%. Mortality is more than 45%. Complex wounds treatment may require a multidisciplinary management. VAC Therapy could be an alternative treatment regarding complex wound. VAC therapy has been recently introduced on skin's graft tissue management reducing skin graft rejection. The use of biological prosthesis has been tested in a contaminated field, better than synthetic meshes, which often need to be removed...
March 2015: Annali Italiani di Chirurgia
A Iu Egorov
The review examines the place of buying addiction in the classification of non-chemical addictions and other mental disorders, and risk factors for its occurrence. The data on the epidemiology of dependence (from 1% to 10% of the population in developed countries) is observed. The characteristics of neurobiology, clinical manifestations and features of addiction comorbidity are described. Modern approaches to therapy and correction are analyzed. It is concluded that buying addiction, of course, refers to the addictive disorders because of the similarity of their neurobiology, clinical manifestations, comorbidity, and approaches to therapy...
2014: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Ran Tao, Xiu-qin Huang, Shu-min Yao
No abstract text is available yet for this article.
May 2007: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
A Pérez Mota, M A Blanco Coronado, J Graus Morales, R Rodero Vázquez de Castro, C Pérez Muñoz, J L de Vicente Bach, C Villalgordo Aparicio
A review of the statistics of the years 2003, 2004 to August 2005 has provided data corresponding to 255 patients that were diagnosed and included in the treatment protocol of chronic hepatitis C. Epidemiologically, the 2/1 man/woman ratio, mean age of 43 years and history of transfusion (transf.) in 18.6% are to be noted. Parenteral drug addicition (PDA) in 17% and alcoholism in 14.1%, of unknown origin in 58.74% of the cases. 79.05% corresponded to genotype 1, 4.74% to genotype 4, 14.22% to genotype 3, and 2...
June 2006: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
H W Aenishänslin, G A Stalder, L Bianchi, F Gudat, H Carmann
Viral hepatitis, proven by biopsy in 44 patients known to be drug addicts or confirmed drug takers had serial clinical, biochemical and (half of them) biopsy studies between 1971 and 1974. At the time of the first biopsy the period of addicition averaged 28.8 months. 30 of the 44 patients had had jaundice. At the time of the last biopsy, 20 of the 44 had chronic persisting and three had chronic active hepatitis, i.e. more than half had a chronic form. A further 12 patients had "hippie" hepatitis, a special form of acute viral hepatitis with piecemeal necrosis, histological evidence of possible change to a chronic state...
April 18, 1975: Deutsche Medizinische Wochenschrift
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