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https://www.readbyqxmd.com/read/28635280/anti-adhesive-activity-and-metabolomics-analysis-of-rat-urine-after-cranberry-vaccinium-macrocarpon-aiton-administration
#1
Gregorio Peron, Pellizzaro Anna, Brun Paola, Elisabetta Schievano, Stefano Mammi, Stefania Sut, Ignazio Castagliuolo, Stefano Dall'Acqua
Cranberry (Vaccinium macrocarpon Aiton) is used to treat non-complicated urinary tract infections (UTIs). A-type procyanidins (PAC-A) are considered the active constituents being able to inhibit bacterial adhesion to the urinary epithelium. However, there are doubts about PAC-A role in UTIs, due to their poor bioavailability, extensive metabolism, limited knowledge about urinary excretion and contradictory clinical trials. The effects of 35 days cranberry (11 mg/kg PAC-A, 4 mg/kg PAC-B) supplementation were studied in healthy rats using a UPLC-MS-based metabolomics approach...
June 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28629073/in-vitro-and-in-vivo-anti-inflammatory-properties-of-green-synthesized-silver-nanoparticles-using-viburnum-opulus-l-fruits-extract
#2
Bianca Moldovan, Luminita David, Adriana Vulcu, Liliana Olenic, Maria Perde-Schrepler, Eva Fischer-Fodor, Ioana Baldea, Simona Clichici, Gabriela Adriana Filip
A green, rapid and cost effective method for the bio-synthesis of silver nanoparticles (AgNPs), using polyphenols present in European cranberry bush fruit extracts was developed. The obtained AgNPs were characterized by ultra-violet visible spectroscopy (UV-VIS), Fourier transform - infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray diffraction patterns (XRD). The average size of the spherical AgNPs was found to be 25nm. The anti-inflammatory effect of the biomaterials was investigated, both in vitro (on HaCaT cell line, exposed to UVB radiation) and in vivo (on acute inflammation model in Wistar rats)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28618237/effect-of-sweetened-dried-cranberry-consumption-on-urinary-proteome-and-fecal-microbiome-in-healthy-human-subjects
#3
Nell Bekiares, Christian G Krueger, Jennifer J Meudt, Dhanansayan Shanmuganayagam, Jess D Reed
The relationship among diet, human health, and disease is an area of growing interest in biomarker research. Previous studies suggest that the consumption of cranberries (Vaccinium macrocarpon) could beneficially influence urinary and digestive health. The present study sought to determine if daily consumption of sweetened dried cranberries (SDC) changes the urinary proteome and fecal microbiome, as determined in a prospective sample of 10 healthy individuals. Baseline urine and fecal samples were collected from the subjects in the fasted (8-12 h) state...
June 15, 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28609455/differential-iridoid-production-as-revealed-by-a-diversity-panel-of-84-cultivated-and-wild-blueberry-species
#4
Courtney P Leisner, Mohamed O Kamileen, Megan E Conway, Sarah E O'Connor, C Robin Buell
Cultivated blueberry (Vaccinium corymbosum, Vaccinium angustifolium, Vaccinium darrowii, and Vaccinium virgatum) is an economically important fruit crop native to North America and a member of the Ericaceae family. Several species in the Ericaceae family including cranberry, lignonberry, bilberry, and neotropical blueberry species have been shown to produce iridoids, a class of pharmacologically important compounds present in over 15 plant families demonstrated to have a wide range of biological activities in humans including anti-cancer, anti-bacterial, and anti-inflammatory...
2017: PloS One
https://www.readbyqxmd.com/read/28608666/-evaluation-of-the-effects-of-a-natural-dietary-supplement-with-cranberry-noxamicina%C3%A2-and-d-mannose-in-recurrent-urinary-infections-in-perimenopausal-women
#5
Vincenzo DE Leo, Valentina Cappelli, Maria G Massaro, Claudia Tosti, Giuseppe Morgante
BACKGROUND: The female genital apparatus, the urinary tract and the perineal supporting tissues share a common embryological origin, whose differentiation depends on the action of estrogens. In adult women, the progressive decline of the ovarian function, with the ensuing estrogen deprivation, reduces tissue tropism causing urogenital atrophy, which makes these organs much more susceptible to traumatisms and urinary infections. The disorders associated with changes in the urogenital tract of peri- and postmenopausal women have significant clinical relevance, both on account of their chronicity and high frequency of occurrence and on account of their having major repercussions on the quality of life of the women, who often have to call their doctor seeking relief for their symptoms...
August 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28545577/proanthocyanidin-accumulation-and-transcriptional-responses-in-the-seed-coat-of-cranberry-beans-phaseolus-vulgaris-l-with-different-susceptibility-to-postharvest-darkening
#6
José A Freixas Coutin, Seth Munholland, Anjali Silva, Sanjeena Subedi, Lewis Lukens, William L Crosby, K Peter Pauls, Gale G Bozzo
BACKGROUND: Edible dry beans (Phaseolus vulgaris L.) that darken during postharvest storage are graded lower and are less marketable than their non-darkened counterparts. Seed coat darkening in susceptible genotypes is dependent upon the availability of proanthocyanidins, and their subsequent oxidation to reactive quinones. Mature cranberry beans lacking this postharvest darkening trait tend to be proanthocyanidin-deficient, although the underlying molecular and biochemical determinants for this metabolic phenomenon are unknown...
May 25, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28530194/solvent-effect-in-the-synthesis-of-hydrophobic-drug-loaded-polymer-nanoparticles
#7
Sandip Pal, Chabita Saha
Quercetin is an abundant flavonoid in fruits, vegetables such as onion, tea leaves, cranberry, radish leaves etc. with numerous biological activities and widely used as an effective antioxidant. Its low solubility in water and chemical decomposition in intestinal environment are predicaments in delivery through dietary or oral intake. Noble polymeric nanoparticles are of particular interest today because of their applications in many areas. Polymer nanoparticles have attracted the interest of many research groups and have been utilised in an increasing number of fields such as site targeted drug delivery in cancer research during the last decades...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28525344/morphometric-abnormalities-in-spleen-and-kidney-of-the-progeny-of-mice-fed-american-cranberry-extract-vaccinium-macrocarpon-during-pregnancy-and-lactation
#8
B J Bałan, S Lewicki, A K Siwicki, M Stelmasiak, P Skopiński, E Skopińska-Różewska, A Wasiutyński, R Zdanowski
Cranberries and cranberry-derived diet supplements are often recommended for the treatment of urinary tract infections, also during pregnancy. These products contain strongly anti-angiogenic chemical compounds which could not be indifferent to the developing fetus. In the present work we evaluated the effect of feeding pregnant and lactating mice American cranberry extract (daily dose 0.88 mg) on the morphology and some parameters of spleen and kidney function of their adult progeny. Six weeks after delivery the morphometry of spleen and kidney, cytometric analysis of spleen lymphocytes, evaluation of humoral response to SRBC (Sheep Red Blood Cells), and examination of serum creatinine/urea concentration, were performed in the offspring...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28501921/cranberry-vaccinium-macrocarpon-extract-treatment-improves-triglyceridemia-liver-cholesterol-liver-steatosis-oxidative-damage-and-corticosteronemia-in-rats-rendered-obese-by-high-fat-diet
#9
Thamara C Peixoto, Egberto G Moura, Elaine de Oliveira, Patrícia N Soares, Deysla S Guarda, Dayse N Bernardino, Xu Xue Ai, Vanessa da S T Rodrigues, Gabriela Rodrigues de Souza, Antonio Jorge Ribeiro da Silva, Mariana S Figueiredo, Alex C Manhães, Patrícia C Lisboa
PURPOSE: Obese individuals have higher production of reactive oxygen species, which leads to oxidative damage. We hypothesize that cranberry extract (CE) can improve this dysfunction in HFD-induced obesity in rats since it has an important antioxidant activity. Here, we evaluated the effects of CE in food intake, adiposity, biochemical and hormonal parameters, lipogenic and adipogenic factors, hepatic morphology and oxidative balance in a HFD model. METHODS: At postnatal day 120 (PN120), male Wistar rats were assigned into two groups: (1) SD (n = 36) fed with a standard diet and (2) HFD (n = 36), fed with a diet containing 44...
May 13, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28491861/enteric-coated-and-highly-standardized-cranberry-extract-reduces-antibiotic-and-nonsteroidal-anti-inflammatory-drug-use-for-urinary-tract-infections-during-radiotherapy-for-prostate-carcinoma
#10
Alberto Bonetta, Giandomenico Roviello, Daniele Generali, Laura Zanotti, Maria Rosa Cappelletti, Chiara Pacifico, Francesco Di Pierro
INTRODUCTION: Worldwide, bacterial resistance to antibiotic therapy is a major concern for the medical community. Antibiotic resistance mainly affects Gram-negative bacteria that are an important cause of lower urinary tract infections (LUTIs). Pelvic irradiation for prostate cancer is a risk factor for LUTIs. Cranberry extract is reported to reduce the incidence of LUTIs. The prophylactic role of an enteric-coated, highly standardized cranberry extract (VO370(®)) in reducing LUTI episodes, urinary discomfort, and nonsteroidal anti-inflammatory drug (NSAID) and antibiotic use during radiotherapy for prostate carcinoma was evaluated...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28475151/antimicrobial-optical-and-mechanical-properties-of-chitosan-starch-films-with-natural-extracts
#11
Jessica I Lozano-Navarro, Nancy P Díaz-Zavala, Carlos Velasco-Santos, Ana L Martínez-Hernández, Beatriz I Tijerina-Ramos, Margarita García-Hernández, José L Rivera-Armenta, Ulises Páramo-García, Adriana I Reyes-de la Torre
Natural extracts possess several kinds of antioxidants (anthocyanins, betalains, thymol, carvacrol, and resveratrol) that have also demonstrated antimicrobial properties. In order to study these properties, extracts from cranberry, blueberry, beetroot, pomegranate, oregano, pitaya, and resveratrol (from grapes) were obtained. Growth inhibition tests of mesophilic aerobes, coliforms, and fungi were conducted in films prepared from the extracts in accordance with Mexican Official Norms (NOM). Optical properties such as transparency and opacity, mechanical properties, and pH were also analyzed in these materials...
May 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28470309/characterization-of-non-dialyzable-constituents-from-cranberry-juice-that-inhibit-adhesion-co-aggregation-and-biofilm-formation-by-oral-bacteria
#12
C C Neto, K A Penndorf, M Feldman, S Meron-Sudai, Z Zakay-Rones, D Steinberg, M Fridman, Y Kashman, I Ginsburg, I Ofek, E I Weiss
An extract prepared from cranberry juice by dialysis known as nondialyzable material (NDM) has been shown previously to possess anti-adhesion activity toward microbial species including oral bacteria, uropathogenic Escherichia coli and Helicobacter pylori. Bioassay-guided fractionation of cranberry NDM was therefore undertaken to identify the anti-adhesive constituents. An aqueous acetone-soluble fraction (NDMac) obtained from Sephadex LH-20 inhibited adhesion-linked activities by oral bacteria, including co-aggregation of oral bacteria Fusobacterium nucleatum with Streptococcus sanguinis or Porphyromonas gingivalis, and biofilm formation by Streptococcus mutans...
May 24, 2017: Food & Function
https://www.readbyqxmd.com/read/28466464/mechanism-of-anti-rotavirus-synergistic-activity-by-epigallocatechin-gallate-and-a-proanthocyanidin-containing-nutraceutical
#13
S M Lipson, G Karalis, L Karthikeyan, F S Ozen, R E Gordon, S Ponnala, J Bao, W Samarrai, E Wolfe
Epigallocatechin gallate (EGCG) of green tea and the nutraceutical CystiCran(®)-40 (containing 40% proanthocyanidins) of the cranberry plant have been associated with antiviral activity. The purpose of this work was to determine the mechanism of antiviral synergy between each compound. Coliphage T4II (phage T4) and the rotavirus strain SA-11(RTV) were used as model virus systems. Individual and combined flavonoids structural and molecular weight analyses were performed by NMR and HPCL/MS, respectively. A suboptimal concentration of EGCG or C-40 alone or in combination reduced phage infectivity by ≤10%...
May 2, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/28433923/uhplc-q-orbitrap-hrms-based-global-metabolomics-reveal-metabolome-modifications-in-plasma-of-young-women-after-cranberry-juice-consumption
#14
Haiyan Liu, Timothy J Garrett, Zhihua Su, Christina Khoo, Liwei Gu
Plasma metabolome in young women following cranberry juice consumption were investigated using a global UHPLC-Q-Orbitrap-HRMS approach. Seventeen female college students, between 21 and 29 years old, were given either cranberry juice or apple juice for three days using a cross-over design. Plasma samples were collected before and after juice consumption. Plasma metabolomes were analyzed using UHPLC-Q-Orbitrap-HRMS followed by orthogonal partial least squares-discriminant analyses (OPLS-DA). S-plot was used to identify discriminant metabolites...
April 7, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28433645/cranberry-capsules-do-not-appear-to-reduce-bacteriuria-and-pyuria-in-elderly-women-residing-in-nursing-homes
#15
Daniel A Ostrovsky
No abstract text is available yet for this article.
March 2, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28423417/multi-species-mating-disruption-in-cranberries-ericales-ericaceae-early-evidence-using-a-flowable-emulsion
#16
Shawn A Steffan, Elissa M Chasen, Annie E Deutsch, Agenor Mafra-Neto
Pheromone-based mating disruption has proven to be a powerful pest management tactic in many cropping systems. However, in the cranberry system, a viable mating disruption program does not yet exist. There are commercially available pheromones for several of the major pests of cranberries, including the cranberry fruitworm, Acrobasis vaccinii Riley (Lepidoptera: Pyralidae) and blackheaded fireworm, Rhopobota naevana (Hübner) (Lepidoptera: Tortricidae). Previous studies have shown that mating disruption represents a promising approach for R...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28421045/cranberry-juice-and-combinations-of-its-organic-acids-are-effective-against-experimental-urinary-tract-infection
#17
Heidi D Jensen, Carsten Struve, Søren B Christensen, Karen A Krogfelt
The antibacterial effect of cranberry juice and the organic acids therein on infection by uropathogenic Escherichia coli was studied in an experimental mouse model of urinary tract infection (UTI). Reduced bacterial counts were found in the bladder (P < 0.01) of mice drinking fresh cranberry juice. Commercially available cranberry juice cocktail also significantly reduced (P < 0.01) bacterial populations in the bladder, as did the hydrophilic fraction of cranberry juice (P < 0.05). Quinic, malic, shikimic, and citric acid, the preponderant organic acids in cranberry juice, were tested in combination and individually...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28415444/formulation-of-thermoreversible-gel-of-cranberry-juice-concentrate-evaluation-biocompatibility-studies-and-its-antimicrobial-activity-against-periodontal-pathogens
#18
Rajeshwari H R, Dinesh Dhamecha, Satveer Jagwani, Dhanashree Patil, Satisha Hegde, Raksha Potdar, Renuka Metgud, Sunil Jalalpure, Subarna Roy, Kiran Jadhav, Neeraj Kumar Tiwari, Sravani Koduru, Shweta Hugar, Suneel Dodamani
The present work aims to investigate the efficacy of thermoreversible gel of cranberry juice concentrate (CJC) as local drug delivery for the treatment of periodontitis. CJC was initially tested for its antimicrobial activities like MIC, MBC, antiadhesion, antibiofilm and time kill assay against the panel of organisms (S. mutans (SM), E. faecalis (EF), A. actinomycetemcomitans (AA), P. gingivalis (PG), T. forsythia (TF)) responsible for periapical and periodontal infections. Antimicrobial activity of CJC showed MIC value of 50mg/ml and MBC value of 100mg/ml with desirable antiadhesion (83-90%) and antibiofilm activity (70-85%)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28364867/preventing-urinary-tract-infections-after-menopause-without-antibiotics
#19
REVIEW
Marta Caretto, Andrea Giannini, Eleonora Russo, Tommaso Simoncini
Urinary tract infections (UTIs) are the most common bacterial infections in women, and increase in incidence after the menopause. It is important to uncover underlying abnormalities or modifiable risk factors. Several risk factors for recurrent UTIs have been identified, including the frequency of sexual intercourse, spermicide use and abnormal pelvic anatomy. In postmenopausal women UTIs often accompany the symptoms and signs of the genitourinary syndrome of menopause (GSM). Antimicrobial prophylaxis has been demonstrated to be effective in reducing the risk of recurrent UTIs in women, but this may lead to drug resistance of both the causative microorganisms and the indigenous flora...
May 2017: Maturitas
https://www.readbyqxmd.com/read/28357646/the-usefulness-of-non-toxic-plant-metabolites-in-the-control-of-bacterial-proliferation
#20
Sergio Gutiérrez, Alfredo Morán, Honorina Martínez-Blanco, Miguel A Ferrero, Leandro B Rodríguez-Aparicio
The effect of generally recognised as safe (GRAS) plant metabolites in regulating the growth of human pathogenic and probiotic bacteria and in the formation of biofilm was investigated. Thymol, carvacrol and eugenol showed the strongest antibacterial action against both pathogenic and probiotic microorganisms, at a subinhibitory concentration (SIC) of ≤50 μg ml(-1). Genistein, hydroquinone, p-hydroxybenzoic acid and resveratrol also showed antibacterial effects but at a wide concentration range (SIC = 50-1000 μg ml(-1))...
March 29, 2017: Probiotics and Antimicrobial Proteins
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