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https://www.readbyqxmd.com/read/28501723/tangeretin-alters-neuronal-apoptosis-and-ameliorates-the-severity-of-seizures-in-experimental-epilepsy-induced-rats-by-modulating-apoptotic-protein-expressions-regulating-matrix-metalloproteinases-and-activating-the-pi3k-akt-cell-survival-pathway
#1
Xiao-Qian Guo, Yu-Ling Cao, Fang Hao, Zhong-Rui Yan, Mei-Ling Wang, Xue-Wu Liu
PURPOSE: Epilepsy is complex neural disarray categorized by recurring seizures. Despite recent advances in pharmacotherapies for epilepsy, its treatment remains a challenge due to the contrary effects of the drugs. As a result, the identification of novel anti-epileptic drugs (AEDs) with neuroprotective properties and few side effects is of great value. Thus, the present study assessed the treatment effects of tangeretin using a rat model of pilocarpine-induced epilepsy. MATERIALS AND METHODS: Separate groups of male Wistar rats received oral administrations of tangeretin at 50, 100, or 200mg/kg for 10 days and then, on the 10th day, they received an intraperitoneal injection of pilocarpine (30mg/kg)...
May 11, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28484748/tangeretin-improves-glucose-uptake-in-a-coculture-of-hypertrophic-adipocytes-and-macrophages-by-attenuating-inflammatory-changes
#2
Hye-Sun Shin, Seong-Il Kang, Hee-Chul Ko, Deok-Bae Park, Se-Jae Kim
Obesity is characterized by a state of chronic low-grade inflammation and insulin resistance, which are aggravated by the interaction between hypertrophic adipocytes and macrophages. In this study, we investigated the effects of tangeretin on inflammatory changes and glucose uptake in a coculture of hypertrophic adipocytes and macrophages. Tangeretin decreased nitric oxide production and the expression of interleukin (IL)-6, IL-1β, tumor necrosis factor-α, inducible nitric oxide synthase, and cyclooxygenase-2 in a coculture of 3T3-L1 adipocytes and RAW 264...
March 2017: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/28474543/neuroprotective-effects-of-citrus-fruit-derived-flavonoids-nobiletin-and-tangeretin-in-alzheimer-s-and-parkinson-s-disease
#3
Nady Braidy, Sahar Behzad, Solomon Habtemariam, Touqeer Ahmed, Maria Daglia, Seyed Mohammad Nabavi, Eduardo Sobarzo-Sanchez, Seyed Fazel Nabavi
Neurodegenerative diseases, namely Alzheimer`s disease and Parkinson's disease represent a deleterious impact worldwide. Despite extensive preclinical and clinical research in neurodegenerative disorders, therapeutic strategies aimed at the prevention and chronic treatment of neurodegenerative conditions have not been successfully translated to the clinic. Therefore, the identification of novel pharmacological intervention derived from natural products is warranted. Nobiletin and tangeretin are important citrus flavonoids derived from the peel and other parts of Citrus L...
March 27, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28433435/fabric-phase-sorptive-extraction-as-a-reliable-tool-for-rapid-screening-and-detection-of-freshness-markers-in-oranges
#4
M Aznar, S Úbeda, C Nerin, A Kabir, K G Furton
A simple, fast and sensitive analyte extraction method based on fabric phase sorptive extraction (FPSE) followed by gas chromatography-mass spectrometry (GC-MS) and ultra-performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-QTOF-MS) analysis was developed for the analysis of 12 volatile compounds that represent most of the principal chemical families possessing different polarities and volatilities. Five FPSE media coated with different sol-gel sorbent chemistries having different polarities and selectivities were studied: long chain poly(dimethylsiloxane) (PDMS), short chain poly(tetrahydrofuran) (PTHF), Carbowax 20M (CW20M), short chain poly(dimethyl siloxane) (SC PDMS) and polyethylene glycol-polypropylene glycol-polyethylene glycol triblock copolymer (PEG-PPG-PEG)...
April 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28416860/characterization-of-phenolic-profile-and-antioxidant-capacity-of-different-fruit-part-from-lemon-citrus-limon-burm-cultivars
#5
Wanpeng Xi, Juanfang Lu, Junping Qun, Bining Jiao
Phenolic composition and antioxidant capacity of different fruit part including peel, pulp, juice, whole fruit and seed from five lemon cultivars (Feiminailao, Cuningmeng Limeng, Pangdelusaningmeng, Beijingningmeng) were investigated. Caffeic acid (9.31-741.4 μg/g FW) and chlorogenic acid (2.7-527.5 μg/g FW) were the dominant phenolic acid in fruit tested, Pangdelusaningmeng (PD) and Limeng peels with the highest contents, respectively. Hesperidin was the predominant flavanone (10.27-3315 μg/g FW), Cuningmeng (CN) peels with the highest level...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28407962/evaluation-of-bioactive-flavonoids-and-antioxidant-activity-in-pericarpium-citri-reticulatae-citrus-reticulata-chachi-during-storage
#6
Manqin Fu, Yujuan Xu, Yulong Chen, Jijun Wu, Yuanshan Yu, Bo Zou, Kejing An, Gengsheng Xiao
A simple and accurate method using high performance liquid chromatography (HPLC) with dual wavelength detection was developed to simultaneously determine the contents of one flavanone glycoside (hesperidin) and five polymethoxylated flavones (PMFs: sinensetin, 4',5,7,8-tetramethoxyflavone, nobiletin, tangeretin and 5-O-desmethyl nobiletin) in Pericarpium Citri Reticulatae (Citrus reticulata 'Chachi') ('Chachi' PCR). By modifying the mobile phase compositions and detection wavelengths, an optimal HPLC condition was obtained, under which the calibration curves of all six compounds exhibited good linearity (R(2)>0...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28314477/extraction-of-nobiletin-from-citrus-unshiu-peels-by-supercritical-fluid-and-its-cre-mediated-transcriptional-activity
#7
Chisato Oba, Masaki Ota, Koichiro Nomura, Hironori Fujiwara, Jiro Takito, Yoshiyuki Sato, Yasushi Ohizumi, Hiroshi Inomata
BACKGROUND: Polymethoxyflavone (PMF) is one of bioactive compounds in Citrus Unshiu and included mainly in the peels rather than the fruits, seeds and leaves. HYPOTHESIS/PURPOSE: Supercritical CO2 extraction is one candidate for selective extraction of polymethoxyflavone and in this study, supercritical CO2 extraction with/without ethanol entrainer from Citrus Unshiu peels was examined at a temperature of 333K and a pressure of 30MPa. METHODS: CRE (cyclic AMP response element)-mediated transcriptional assay was examined by using the extracts from supercritical fluid extraction...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28245567/permeation-of-polymethoxyflavones-into-the-mouse-brain-and-their-effect-on-mk-801-induced-locomotive-hyperactivity
#8
Satoshi Okuyama, Kohei Miyazaki, Rie Yamada, Yoshiaki Amakura, Morio Yoshimura, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukawa
Accumulating data have indicated that citrus polymethoxyflavones (PMFs) have the ability to affect brain function. In the present study, we showed that 3,5,6,7,8,3',4'-heptamethoxy- flavone (HMF) given intraperitoneally to mice was immediately detected in the brain and that the permeability of the brain tissues to it was significantly higher than that of other citrus PMFs (nobiletin, tangeretin, and natsudaidain). The permeation of these PMFs into the brain well correlated with their abilities to suppress MK-801-induced locomotive hyperactivity, suggesting that HMF had the ability to act directly in the brain...
February 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28224016/characterization-of-major-metabolites-of-polymethoxylated-flavonoids-in-pericarpium-citri-reticulatae-using-liver-microsomes-immobilized-on-magnetic-nanoparticles-coupled-with-uplc-ms-ms
#9
Jun Lei, Ying Xue, Yi-Ming Liu, Xun Liao
The peels of citrus fruits (Pericarpium Citri Reticulatae, PCR) have long been used in traditional Chinese medicines (TCMs). Polymethoxylated flavonoids (PMFs) were found to be the main components present in PCR extracts, but their metabolism remains unclear which restrain the utilization of this TCM. In the present work, rat liver microsomes were immobilized on magnetic nanoparticles (LMMNPs) for in vitro metabolic study on the whole PMFs of PCR. LMMNPs were characterized by transmission electron microscope and Fourier-transform infrared spectrum...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28182421/encapsulation-of-polymethoxyflavones-in-citrus-oil-emulsion-based-delivery-systems
#10
Ying Yang, Chengying Zhao, Jingjing Chen, Guifang Tian, David Julian McClements, Hang Xiao, Jinkai Zheng
The purpose of this work was to elucidate the effects of citrus oil type on polymethoxyflavone (PMF) solubility and on the physicochemical properties of PMF-loaded emulsion-based delivery systems. Citrus oils were extracted from mandarin, orange, sweet orange, and bergamot. The major constituents were determined by GC/MS: sweet orange oil (97.4% d-limonene); mandarin oil (72.4% d-limonene); orange oil (67.2% d-limonene); and bergamot oil (34.6% linalyl acetate and 25.3% d-limonene). PMF-loaded emulsions were fabricated using 10% oil phase (containing 0...
February 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28165379/in-vitro-lipophilic-antioxidant-capacity-antidiabetic-and-antibacterial-activity-of-citrus-fruits-extracts-from-aceh-indonesia
#11
Ernawita, Ruri Agung Wahyuono, Jana Hesse, Uta-Christina Hipler, Peter Elsner, Volker Böhm
This study reports in vitro lipophilic antioxidant, inhibition of α-amylase and antibacterial activities of extracts of peel and pulp of citrus samples from Aceh, Indonesia. HPLC (high-performance liquid chromatography), phytochemical, and FTIR (fourier transform infrared) analysis detected carotenoids, flavonoids, phenolic acids and terpenoids, contributing to the biological potencies. Most peel and pulp extracts contained lutein and lower concentrations of zeaxanthin, α-carotene, β-carotene and β-cryptoxanthin...
February 3, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28152057/potent-effects-of-flavonoid-nobiletin-on-amplitude-period-and-phase-of-the-circadian-clock-rhythm-in-per2-luciferase-mouse-embryonic-fibroblasts
#12
Ayako Shinozaki, Kenichiro Misawa, Yuko Ikeda, Atsushi Haraguchi, Mayo Kamagata, Yu Tahara, Shigenobu Shibata
Flavonoids are natural polyphenols that are widely found in plants. The effects of flavonoids on obesity and numerous diseases such as cancer, diabetes, and Alzheimer's have been well studied. However, little is known about the relationships between flavonoids and the circadian clock. In this study, we show that continuous or transient application of flavonoids to the culture medium of embryonic fibroblasts from PER2::LUCIFERASE (PER2::LUC) mice induced various modifications in the circadian clock amplitude, period, and phase...
2017: PloS One
https://www.readbyqxmd.com/read/28138336/chemical-compositions-chromatographic-fingerprints-and-antioxidant-activities-of-citri-exocarpium-rubrum-juhong
#13
Yang Zhao, Chun-Pin Kao, Chi-Ren Liao, Kun-Chang Wu, Xin Zhou, Yu-Ling Ho, Yuan-Shiun Chang
BACKGROUND: Citri Exocarpium Rubrum (CER), which is known as Juhong in Chinese, is the dried exocarp of Citrus reticulata Blanco and its cultivars (Fam. Rutaceae) and is currently used in Chinese medicine to protect the stomach and eliminate dampness and phlegm. The main aim of this study was to develop a high-performance liquid chromatography ultraviolet mass spectrometry (HPLC-UV-MS) method for determining the chemical compositions and fingerprint of CER. We also evaluated the antioxidant properties of CER based on its 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, ferric ion reducing antioxidant power (FRAP) and trolox equivalent antioxidant capacity (TEAC) assays...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28032362/prioritizing-pharmacokinetic-drug-interaction-precipitants-in-natural-products-application-to-oatp-inhibitors-in-grapefruit-juice
#14
Emily J Johnson, Christina S Won, Kathleen Köck, Mary F Paine
Natural products, including botanical dietary supplements and exotic drinks, represent an ever-increasing share of the health-care market. The parallel ever-increasing popularity of self-medicating with natural products increases the likelihood of co-consumption with conventional drugs, raising concerns for unwanted natural product-drug interactions. Assessing the drug interaction liability of natural products is challenging due to the complex and variable chemical composition inherent to these products, necessitating a streamlined preclinical testing approach to prioritize precipitant individual constituents for further investigation...
April 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/27979270/enhancement-of-physical-stability-and-bioaccessibility-of-tangeretin-by-soy-protein-isolate-addition
#15
Jiawei Wan, Dong Li, Rong Song, Bakht Ramin Shah, Bin Li, Yan Li
Soy protein isolate (SPI) was selected to fabricate supersaturated self-emulsifying nanoemulsions, aiming to enhance physical stability and bioaccessibility of hydrophobic tangeretin. Dissolution studies demonstrated that tangeretin had the highest solubility in Tween 80, followed by oil phase solutions, and polymer solutions. Supersaturated tangeretin in oil phases easily formed crystals. That metastable zone was found to vary with its initial concentrations. After encapsulation by nanoemulsions, the addition of glycerol compressed the retention amount of tangeretin from 76% to 53%, but benefited the transparency...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27806407/tangeretin-inhibits-il-12-expression-and-nf-%C3%AE%C2%BAb-activation-in-dendritic-cells-and-attenuates-colitis-in-mice
#16
Su-Hyeon Eun, Je-Te Woo, Dong-Hyun Kim
In the preliminary study, tangeretin (5,6,7,8,4'-pentamethoxy flavone), a major constituent of the pericarp of Citrus sp., inhibited TNF-α, IL-12, and IL-23 expression and nuclear factor kappa-B activation in lipopolysaccharide-stimulated dendritic cells; however, it did not affect IL-10 expression. Furthermore, tangeretin (5, 10, and 20 µM) suppressed the activation and translocation of nuclear factor kappa-B (p65) into the nuclei in vitro by inhibiting the binding of lipopolysaccharide on dendritic cells...
April 2017: Planta Medica
https://www.readbyqxmd.com/read/27616468/tangeretin-attenuates-cisplatin-induced-renal-injury-in-rats-impact-on-the-inflammatory-cascade-and-oxidative-perturbations
#17
Hany H Arab, Wafaa R Mohamed, Bassant M Barakat, El-Shaimaa A Arafa
BACKGROUND: Despite the efficacy of cisplatin as a chemotherapeutic agent against various cancers, its clinical utility is limited by serious adverse reactions including nephrotoxicity. AIM: The current study aims to investigate the protective potential of tangeretin, a citrus flavone with marked antioxidant actions, against cisplatin-induced renal injury in rats. METHODS: Tangeretin was administered at 50 and 100 mg/kg p.o. for 1 week starting one day before cisplatin (7...
October 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27470446/corrigendum-to-tangeretin-a-citrus-pentamethoxyflavone-antagonizes-abcb1-mediated-multidrug-resistance-by-inhibiting-its-transport-function-pharm-res-110-2016-193-204
#18
Sen-Ling Feng, Zhong-Wen Yuan, Xiao-Jun Yao, Wen-Zhe Ma, Liang Liu, Zhong-Qiu Liu, Ying Xie
No abstract text is available yet for this article.
July 25, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27379685/activation-of-human-bitter-taste-receptors-by-polymethoxylated-flavonoids
#19
Yuki Kuroda, Riko Ikeda, Toyomi Yamazaki, Keisuke Ito, Kazunari Uda, Keiji Wakabayashi, Tatsuo Watanabe
Tangeretin and nobiletin are polymethoxylated flavonoids in citrus peel. Both tangeretin and nobiletin are bitter; however, their bitterness has not been evaluated using human bitter taste receptors (hTAS2Rs). We screened 25 kinds of hTAS2Rs and found that hTAS2R14 and hTAS2R46 received both compounds.
October 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27313153/simultaneous-quantification-of-seven-bioactive-flavonoids-in-citri-reticulatae-pericarpium-by-ultra-fast-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#20
Lian-Hua Zhao, Hong-Zheng Zhao, Xue Zhao, Wei-Jun Kong, Yi-Chen Hu, Shi-Hai Yang, Mei-Hua Yang
INTRODUCTION: Citri Reticulatae Pericarpium (CRP) is a commonly-used traditional Chinese medicine with flavonoids as the major bioactive components. Nevertheless, the contents of the flavonoids in CRP of different sources may significantly vary affecting their therapeutic effects. Thus, the setting up of a reliable and comprehensive quality assessment method for flavonoids in CRP is necessary. OBJECTIVE: To set up a rapid and sensitive ultra-fast liquid chromatography coupled with tandem mass spectrometry (UFLC-MS/MS) method for simultaneous quantification of seven bioactive flavonoids in CRP...
May 2016: Phytochemical Analysis: PCA
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