keyword
https://read.qxmd.com/read/38533408/untargeted-metabolomics-in-anectocillus-roxburghii-with-habitat-heterogeneity-and-the-key-abiotic-factors-affecting-its-active-ingredients
#1
JOURNAL ARTICLE
Xinkai Lyu, Haixin Diao, Jiaxue Li, Zhixia Meng, Bing Li, Lisi Zhou, Shunxing Guo
INTRODUCTION: Anoectochilus roxburghii is a rare, endangered herb with diverse pharmacological properties. Understanding the main metabolite types and characteristics of wild A. roxburghii is important for efficiently utilizing resources and examining quality according to origin. METHODS: Samples were collected from the main production areas across five regions in Fujian Province, China. An untargeted metabolomics analysis was performed on the entire plants to explore their metabolic profiles...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38461715/short-term-steaming-during-processing-impacts-the-quality-of-citri-reticulatae-chachi-peel
#2
JOURNAL ARTICLE
Shiheng Chen, Ziying Chen, Dylan O'Neill Rothenberg, Yong Long, Huafeng Li, Xiaoyang Zeng, Zhen Zeng, Xiaoli Mo, Dunying Wu, Yinghong Liao, Yahui Huang, Sui Xiao, Xu Zhang
Citrus peel is a commonly used food-medicine material in the production of fast-moving consumer goods (FMCGs). For instance, Ganpu tea is manufactured by combining the peel of Citri Reticulatae 'Chachi' (PCRC) with Pu-erh tea. The alleviated irritation of PCRC through years of aging makes Citri reticulatae Pericarpium a traditional Chinese medicine. Herein, we introduced short-term steaming into the processing of PCRC to favor the quick removal of its irritation while retaining its food-medicine properties...
March 8, 2024: Food Chemistry
https://read.qxmd.com/read/38342153/unraveling-the-pharmacodynamic-substances-and-possible-mechanism-of-trichosanthis-pericarpium-in-the-treatment-of-coronary-heart-disease-based-on-plasma-pharmacochemistry-network-pharmacology-and-experimental-validation
#3
JOURNAL ARTICLE
Xiao-Yu Zhang, Kai-Rou Xia, Ya-Ni Wang, Pei Liu, Er-Xin Shang, Cong-Yan Liu, Yu-Ping Liu, Ding Qu, Wei-Wen Li, Jin-Ao Duan, Yan Chen, Huang-Qin Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Coronary heart disease (CHD) is a chronic disease that seriously threatens people's health and even their lives. Currently, there is no ideal drug without side effects for the treatment of CHD. Trichosanthis Pericarpium (TP) has been used for several years in the treatment of diseases associated with CHD. However, there is still a need for systematic research to unravel the pharmacodynamic substances and possible mechanism of TP in the treatment of coronary heart...
February 9, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38323083/the-in-vivo-study-on-antioxidant-activity-of-wendan-decoction-in-treating-hyperlipidemia-a-pharmacokinetic-pharmacodynamic-pk-pd-model
#4
JOURNAL ARTICLE
Nan Xu, Muhammad Ijaz, Yishuo Shu, Peng Wang, Lei Ma, Ping Wang, Hailing Ding, Muhammad Shahbaz, Haiyan Shi
Background: Wendan Decoction (WDD) is a six-herb Chinese medicine recipe that was first mentioned in about 652 AD. It is frequently used to treat hyperlipidemic patients' clinical complaints. According to reports, oxidative stress has a significant role in hyperlipidemia. Purpose: There has not yet been a thorough pharmacokinetic-pharmacodynamic (PK-PD) examination of the clinical efficacy of WDD in the context of hyperlipemia-related oxidative stress. Therefore, the goal of this research is to explore the antioxidant essence of WDD by developing a PK-PD model, ordering to assure its implication in treating hyperlipidemia in medical practice...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38201140/citrus-peel-extracts-effective-inhibitors-of-heterocyclic-amines-and-advanced-glycation-end-products-in-grilled-pork-meat-patties
#5
JOURNAL ARTICLE
Yang Xu, Guangyu Li, Lan Mo, Maiquan Li, Jie Luo, Qingwu Shen, Wei Quan
In the present study, citrus peels were extracted using various conventional and deep eutectic solvents (DESs). Compared to other citrus peel extracts, the DES extract based on choline chloride showed notably higher total phenolic and flavonoid content levels, along with superior antioxidant activity, among these extracts. Consequently, this study aimed to further investigate the inhibitory effects of the choline chloride based DES extract on the production of both free and bound heterocyclic amines (HAs) and advanced glycation end products (AGEs) in roast pork meat patties...
December 28, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38158492/tangeretin-enhances-pancreatic-beta-tc-6-function-by-ameliorating-tunicamycin-induced-cellular-perturbations
#6
JOURNAL ARTICLE
Eveline M Anto, P Jayamurthy
BACKGROUND: Pancreatic beta cell health and its insulin-secreting potential are severely compromised under the diabetic condition. One of the key mediators of beta cell dysfunction is endoplasmic reticulum (ER) stress. Pharmacological intervention of ER stress and associated complications in pancreatic beta cells may be an effective strategy for the management of diabetes. In the present study, we evaluated the efficacy of tangeretin, a citrus pentamethoxyflavone, in the alleviation of ER stress and associated perturbations in pancreatic Beta-TC-6 cell lines...
December 29, 2023: Molecular Biology Reports
https://read.qxmd.com/read/38147126/tangeretin-attenuates-acute-lung-injury-in-septic-mice-by-inhibiting-ros-mediated-nlrp3-inflammasome-activation-via-regulating-plk1-ampk-drp1-signaling-axis
#7
JOURNAL ARTICLE
Yuntao Liu, Yuting Zhang, Guoxing You, Danwen Zheng, Zhipeng He, Wenjie Guo, Kim Antonina, Ziyadullaev Shukhrat, Banghan Ding, Jie Zan, Zhongde Zhang
OBJECTIVE: NLRP3 inflammasome-mediated pyroptosis of macrophage acts essential roles in the progression of sepsis-induced acute lung injury (ALI). Tangeretin (TAN), enriched in citrus fruit peel, presents anti-oxidative and anti-inflammatory effects. Here, we aimed to explore the potentially protective effect of TAN on sepsis-induced ALI, and the underlying mechanism of TAN in regulating NLRP3 inflammasome. MATERIAL AND METHODS: The effect of TAN on sepsis-induced ALI and NLRP3 inflammasome-mediated pyroptosis of macrophage were examined in vivo and in vitro using a LPS-treated mice model and LPS-induced murine macrophages, respectively...
December 26, 2023: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38144808/differential-analysis-of-phytochemistry-and-antioxidant-activity-in-five-citrus-by-products-based-on-chromatography-mass-spectrometry-and-spectrum-effect-relationships
#8
JOURNAL ARTICLE
Jiangyi Luo, Ling Liang, Qinling Xie, Yixing Qiu, Sai Jiang, Yupei Yang, Lijuan Zhu, Yangfen Fu, Shenghuang Chen, Wei Wang, Hanwen Yuan
The unripe fruit or peel of Citrus aurantium L., Citrus sinensis Osbeck, and Citrus reticulata Blanco are often disregarded due to perceptions of their marginal value. The present study was undertaken to explore the differences in phytochemical composition and bioactive properties of five citrus by-products in China and demonstrate their potential value. 214 compounds were systematically identified using LC-Orbitrap-MS analysis. Among them, narirutin, naringin, hesperidin, and neohesperidin were established as essential compounds for the discrimination and authentication of the five by-products via a combination of LC-MS, HPLC, and TLC techniques...
December 30, 2023: Food chemistry: X
https://read.qxmd.com/read/38144759/chemical-characterization-and-discovery-of-novel-quality-markers-in-citrus-aurantium-l-fruit-from-traditional-cultivation-areas-in-china-using-gc-ms-based-cuticular-waxes-analysis
#9
JOURNAL ARTICLE
Yan Li, Jie Liu, Jie Li, Haijing Xiao, Yiyun Xu, Siqing Fan, Zhaoqi Xie, Min Guo, Jiaxin Yang, Xue Jing, Chunsong Cheng
Citrus aurantium L. fruit is a commonly used Chinese medicine whose therapeutic effects tends to be affected by growing conditions. In order to gain insights into the effects of growing location on the cuticular wax composition of C. aurantium L. fruit, we analyzed the differences in the wax composition of its fruits collected from different regions. The findings showed that the cuticular waxes in the fruit peels were mainly composed of fatty acids, which differed quantitatively in the chemical profiles of C...
December 30, 2023: Food chemistry: X
https://read.qxmd.com/read/38074289/tangeretin-confers-neuroprotection-cognitive-and-memory-enhancement-in-global-cerebral-ischemia-in-rats
#10
JOURNAL ARTICLE
Narayanarao Alla, Sujatha Palatheeya, Siva Reddy Challa, Ramakrishna Kakarla
Global cerebral ischemia is commonly associated with neurological deficits, including cognitive and memory impairments. The present study aims to investigate the neuroprotective, cognitive, and memory enhancement effects of Tangeretin, a flavonoid against global cerebral ischemia in rats. Bilateral common carotid artery occlusion (BCCAO) and reperfusion injury method was used to induce global cerebral ischemia in rats. Motor, cognitive, and memory functions were evaluated using rotarod, grip strength, Y-maze, and Morris water maze...
January 2024: 3 Biotech
https://read.qxmd.com/read/38027235/tangeretin-inhibits-hepatocellular-carcinoma-proliferation-and-migration-by-promoting-autophagy-related-beclin1-retraction
#11
(no author information available yet)
[This retracts the article DOI: 10.2147/CMAR.S200974.].
2023: Cancer Management and Research
https://read.qxmd.com/read/38022093/tangeretin-s-anti-apoptotic-signaling-mechanisms-in-oral-cancer-cells-in-vitro-anti-cancer-activity
#12
JOURNAL ARTICLE
Venkatakarthikeswari Gv, Priyadharshini Ranganathan, Sinduja Palati
Introduction Citrus fruit peels contain Tangeretin , a natural chemical flavonoid that reinforces plant cell walls and serves as a defense mechanism. Apoptosis, growth inhibition, anti-oxidant, anti-diabetic, and anti-cancer activities are only a few of its many qualities. Tangeretin 's principal function is to shield healthy cells or tissues from the harmful effects of chemotherapy. The purpose of this study was to investigate the apoptotic activity of Tangeretin 's impact on KB (oral cancer cells) cell lines...
October 2023: Curēus
https://read.qxmd.com/read/37986422/integrated-metabolomics-and-network-pharmacology-to-reveal-antioxidant-mechanisms-and-potential-pharmacological-ingredients-of-citrus-herbs
#13
JOURNAL ARTICLE
Xiaomin Cao, Kaixin Shi, Yang Xu, Peipei Zhang, Hongyan Zhang, Siyi Pan
The benefits of citrus herbs are strongly associated with their secondary metabolites. In the study, we conducted widely-targeted metabolomics and ultra-high performance liquid chromatography (UPLC) to compare the variability of ingredients in four citrus herbs. In total, we discovered 1126 secondary metabolites, primarily comprising flavonoids, phenolic acids, lignans and coumarins, and alkaloids. Differential metabolites of citrus herbs were searched by multivariate statistical analysis. Notably, Citri Reticulatae Pericarpium contained higher levels of flavonoids, while Zhique and Huajuhong demonstrated a greater abundance of coumarins...
December 2023: Food Research International
https://read.qxmd.com/read/37955544/antiadipogenic-effect-of-citrus-flavonoids-evidence-from-rna-sequencing-analysis-and-activation-of-ampk-in-3t3-l1-adipocytes
#14
JOURNAL ARTICLE
Premkumar Natraj, Priyanka Rajan, Yoon A Jeon, Sang Suk Kim, Young Jae Lee
Citrus fruits are rich in dietary flavonoids and have many health benefits, but their antiadipogenic mechanism of action and their impact on lipid metabolism remain unclear. In this study, we investigated the effect of citrus flavonoids, namely, hesperidin (HES), narirutin (NAR), nobiletin (NOB), sinensetin (SIN), and tangeretin (TAN), on preventing fat cell development by gene expression in 3T3-L1 adipocytes. Among the citrus flavonoids tested, HES and NAR significantly reduced fat storage and triglyceride levels and increased glucose uptake in 3T3-L1 adipocytes...
November 13, 2023: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/37933488/dietary-tangeretin-improved-antibiotic-associated-diarrhea-in-mice-by-enhancing-the-intestinal-barrier-function-regulating-the-gut-microbiota-and-metabolic-homeostasis
#15
JOURNAL ARTICLE
Bin Chen, Xun Yang, Minmin Zhan, Yilu Chen, Jingyi Xu, Jie Xiao, Hang Xiao, Mingyue Song
Antibiotic-associated diarrhea is mediated by antibiotic treatment and is usually caused by the disruption of the intestinal barrier, gut microbiota, and metabolic balance. To identify a dietary strategy that can mitigate the side effects of antibiotics, this study investigated the effect of tangeretin on antibiotic-associated diarrhea in C57BL/6 mice. The results revealed that dietary tangeretin significantly ameliorated symptoms of antibiotic-associated diarrhea, as evidenced by the decreased diarrhea status scores, the reduced fecal water content, the decreased caecum/body weight ratio, and the alleviated colonic tissue damage...
November 7, 2023: Food & Function
https://read.qxmd.com/read/37893474/cognitive-impairment-in-parkinson-s-disease-an-updated-overview-focusing-on-emerging-pharmaceutical-treatment-approaches
#16
REVIEW
Yildiz Degirmenci, Efthalia Angelopoulou, Vasiliki Epameinondas Georgakopoulou, Anastasia Bougea
Cognitive impairment in patients with Parkinson's disease (PD) is one of the commonest and most disabling non-motor manifestations during the course of the disease. The clinical spectrum of PD-related cognitive impairment includes subjective cognitive decline (SCD), mild cognitive impairment (MCI) and PD dementia (PDD). As the disease progresses, cognitive decline creates a significant burden for the family members and/or caregivers of patients with PD, and has a great impact on quality of life. Current pharmacological treatments have demonstrated partial efficacy and failed to halt disease progression, and novel, effective, and safe therapeutic strategies are required...
October 1, 2023: Medicina
https://read.qxmd.com/read/37833248/kindlin-2-in-myoepithelium-controls-luminal-progenitor-commitment-to-alveoli-in-mouse-mammary-gland
#17
JOURNAL ARTICLE
Zhenbin Wang, Lei Zhang, Bing Li, Jiagui Song, Miao Yu, Jing Zhang, Ceshi Chen, Jun Zhan, Hongquan Zhang
Myoepithelium plays an important role in mammary gland development, but less is known about the molecular mechanism underlying how myoepithelium controls acinus differentiation during gestation. Herein, we found that loss of Kindlin-2 in myoepithelial cells impaired mammary morphogenesis, alveologenesis, and lactation. Using five genetically modified mouse lines combined with single-cell RNA sequencing, we found a Kindlin-2-Stat3-Dll1 signaling cascade in myoepithelial cells that inactivates Notch signaling in luminal cells and consequently drives luminal progenitor commitment to alveolar cells identity...
October 13, 2023: Cell Death & Disease
https://read.qxmd.com/read/37781713/tangeretin-attenuates-bleomycin-induced-pulmonary-fibrosis-by-inhibiting-epithelial-mesenchymal-transition-via-the-pi3k-akt-pathway
#18
JOURNAL ARTICLE
Jiang Li, Qian Wei, Ke Song, Youxin Wang, Yuxin Yang, Miao Li, Jiaying Yu, Guangxu Su, Luyuan Peng, Bendong Fu, Pengfei Yi
Background: Pulmonary fibrosis (PF) is a terminal pathological change in a variety of lung diseases characterized by excessive deposition of extracellular matrix, for which effective treatment is lacking. Tangeretin (Tan), a flavonoid derived from citrus, has been shown to have a wide range of pharmacological effects. This study aimed to investigate the role and potential mechanisms of Tan on pulmonary fibrosis. Methods: A model of pulmonary fibrosis was established by administering bleomycin through tracheal drip, followed by administering Tan or pirfenidone through gavage...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37765037/anticancer-potential-of-flavonoids-an-overview-with-an-emphasis-on-tangeretin
#19
REVIEW
Francisco Canindé Ferreira de Luna, Wallax Augusto Silva Ferreira, Samir Mansour Moraes Casseb, Edivaldo Herculano Correa de Oliveira
Natural compounds with pharmacological activity, flavonoids have been the subject of an exponential increase in studies in the field of scientific research focused on therapeutic purposes due to their bioactive properties, such as antioxidant, anti-inflammatory, anti-aging, antibacterial, antiviral, neuroprotective, radioprotective, and antitumor activities. The biological potential of flavonoids, added to their bioavailability, cost-effectiveness, and minimal side effects, direct them as promising cytotoxic anticancer compounds in the optimization of therapies and the search for new drugs in the treatment of cancer, since some extensively antineoplastic therapeutic approaches have become less effective due to tumor resistance to drugs commonly used in chemotherapy...
August 30, 2023: Pharmaceuticals
https://read.qxmd.com/read/37760009/evaluation-of-antioxidant-activity-and-drug-delivery-potential-of-cell-derived-extracellular-vesicles-from-citrus-reticulata-blanco-cv-dahongpao
#20
JOURNAL ARTICLE
Shunjie Li, Zimao Ye, Lintao Zhao, Yijun Yao, Zhiqin Zhou
Plant extracellular vesicles (PEVs) have attracted increasing attention due to their rich composition, good antioxidant and anti-inflammatory activity, and ability to transport drugs. As a common fruit, citrus is an ideal material for extracting PEVs because of the diversity and abundance of bioactive substances in it. In our study, citrus-derived extracellular vesicles (CEVs) were extracted from red mandarin ( Citrus reticulata Blanco cv. 'Dahongpao') and it was found that they contain high levels of lipids, proteins, and carbohydrates...
September 1, 2023: Antioxidants (Basel, Switzerland)
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