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Thyroid and coronary heart disease

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https://www.readbyqxmd.com/read/29928786/antitumor-perspectives-of-oleuropein-and-its-metabolite-hydroxytyrosol-recent-updates
#1
REVIEW
Muhammad Imran, Muhammad Nadeem, Syed Amir Gilani, Shaista Khan, Muhammad Wasim Sajid, Rai Muhammad Amir
Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4-dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the reduction of coronary heart diseases and a certain type of cancers. Both olive oil phenols have an effective role counter to cell proliferation, cell growth, migration, invasion, and angiogenesis...
June 21, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29897016/the-impact-of-hypothyroidism-and-heart-failure-on-hospitalization-risk
#2
Kevin Ro, Alexander D Yuen, Lin Du, Clarissa C Ro, Christian D Seger, Michael W Yeh, Angela M Leung, Connie M Rhee
BACKGROUND: Prior studies suggest that the relationship between hypothyroidism and mortality is dependent on underlying cardiovascular risk. Little is known about the association of hypothyroidism with hospitalization risk, and how these associations are modified by cardiovascular status. METHODS: We examined the association of thyroid status, defined by serum thyrotropin (TSH), with hospitalization risk among patients who received care from a large university-based tertiary care center over 1990-2015...
June 13, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29691578/-effects-of-thyroid-hormone-on-macrophage-dysfunction-induced-by-oxidized-low-density-lipoprotein
#3
Yu Ning, Ming Zhang, Yun-Hui DU, Hui-Na Zhang, Lin-Yi Li, Yan-Wen Qin, Wan-Wan Wen, Quan-Ming Zhao
It has been recognized that patients with hypothyroidism have higher risks of atherosclerosis and coronary heart disease, however, the mechanisms are largely unknown. Considering that macrophage dysfunction plays an important role in the formation and development of atherosclerosis plaques, this study aimed to investigate the direct effects of thyroid hormone on macrophage functions and to provide new insight for the mechanism of hypothyroid atherosclerosis. RAW264.7 cells (mouse leukaemic monocyte macrophage cell line) were incubated with oxidized low-density lipoprotein (oxLDL) to establish macrophage foam cells model in vitro, and the protective effects of different concentration of thyroxine (T4) on the macrophage foam cells function were explored...
April 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29673259/exploring-potential-biomarkers-associated-with-health-related-quality-of-life-in-patients-with-coronary-artery-disease-and-heart-failure
#4
Nijole Kazukauskiene, Julius Burkauskas, Jurate Macijauskiene, Narseta Mickuviene, Julija Brozaitiene
OBJECTIVE: There has been a lack of research examining associations between biomarkers and health-related quality of life (HRQoL) in patients with coronary artery disease and heart failure. In patients with coronary artery disease and heart failure, we aimed to explore potential associations between biomarkers of health such as serum levels of thyroid hormones, N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), inflammatory biomarkers and HRQoL. METHODS: In sum, 482 patients (75% male; mean age 58±10 years) with coronary artery disease and heart failure were evaluated for socio-demographic and clinical coronary artery disease risk factors...
April 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29564986/exploring-the-influence-of-mutation-on-transthyretin-aggregation-in-heart-disease
#5
Ankita Sharma, Monu, Sagarika Biswas
BACKGROUND: Transthyretin (TTR) is the transporter protein (55 kDA) that carries retinol binding protein and thyroxin (T4) in its functional tetramer form. Presence of mutation in this protein (TTR) may lead to the dissociation of tetramers to monomer which unfolds and self associates to form amyloid aggregates. Aggregation of this protein has been found to be associated with various life threatening disorders such as coronary artery disease (CAD) which is the major cause of mortality and morbidity worldwide...
March 20, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29484302/the-effect-of-thyroid-dysfunction-on-the-cardiovascular-risk-of-type-2-diabetes-mellitus-patients-in-ghana
#6
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Ishmael Kyei
Background: Thyroid dysfunction is known to exaggerate the coronary heart disease (CHD) risk associated with type 2 diabetes mellitus (T2DM) among whites. The effect is yet to be studied among African populations. Methods: This is a cross-sectional study involving 780 T2DM patients enrolled in a diabetes clinic in Kumasi, Ghana. CHD risk was estimated using the Framingham and UKPDS risk scores. Risks were categorised as low (<10%), intermediate (10-19%), and high (≥20%)...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29357324/circulating-mir-146a-may-be-a-potential-biomarker-of-coronary-heart-disease-in-patients-with-subclinical-hypothyroidism
#7
Xiaohui Quan, Yuqiang Ji, Chunyan Zhang, Xuan Guo, Yan Zhang, Shan Jia, Weidong Ma, Yajie Fan, Congxia Wang
BACKGROUND/AIMS: Subclinical hypothyroidism (SCH) plays a crucial role in the development and progression of coronary heart disease (CHD). However, any associated changes in the circulating microRNAs (miRNAs) levels and slightly elevated thyroid stimulating hormone (TSH) levels in CHD patients are unknown. miR-146a is a well known miRNA associated with inflammatory autoimmune diseases. Here, we evaluated miR-146a expression in patients, with the goal of re-evaluating the effect of SCH on CHD...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29132170/thyroid-dysfunction-states-and-incident-cardiovascular-events-the-tehran-thyroid-study
#8
Maryam Tohidi, Arash Derakhshan, Samaneh Akbarpour, Atieh Amouzegar, Ladan Mehran, Aidin Baghbani-Oskouei, Fereidoun Azizi, Farzad Hadaegh
The objective of the study was to investigate the relation of different thyroid function states with the incidence of cardiovascular disease (CVD)/coronary heart disease (CHD) among a Middle-Eastern population with a high incidence of CVD/CHD. A total of 3975 participants entered the study (43.6% men). According to their thyroid stimulating hormone (TSH) and free thyroxin (FT4) levels, the participants were categorized into 5 groups: euthyroid, subclinical hypothyroidism, overt hypothyroidism, subclinical hyperthyroidism, and overt hyperthyroidism...
January 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29107455/type-2-diabetes-mellitus-and-risk-of-open-angle-glaucoma-development-in-koreans-an-11-year-nationwide-propensity-score-matched-study
#9
Y Jung, K Han, H-Y L Park, C K Park
PURPOSE: To evaluate the risk of primary open-angle glaucoma (POAG) development in type 2 diabetes mellitus (T2DM) patients. METHODS: In this 11-year longitudinal study based on the Korean National Health Insurance research database, the data collected comprised 1,025,340 (2.2%) participants who were randomly selected from 46,605,433 Korean residents in 2002. The database was analyzed to identify participants with an initial diagnosis of T2DM in 2003-2004. The control group was composed of participants without T2DM who were propensity-score-matched, five controls per T2DM patient, according to age, gender, household income, residential area and underlying diseases, including hypertension, dyslipidaemia, coronary heart disease, cerebrovascular disease and thyroid disease...
October 26, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29102035/impact-of-hypothyroidism-on-occurrence-and-outcome-of-acute-coronary-syndrome-from-the-national-inpatient-sample
#10
Rashmi Dhital, Sijan Basnet, Dilli Ram Poudel
Thyroid hormones have a profound effect on cardiovascular physiology. We utilized a large national inpatient database in the United States (National Inpatient Sample) to study hypothyroidism in relation to the prevalence of coronary heart disease (CHD) and its impact on outcomes (mortality, the length of stay, and hospitalization cost) in the acute coronary syndrome (ACS) subgroup of CHD patients. We found that although hypothyroidism has an increased association with CHD (odds ratio [OR] 1.11, 95% confidence interval [CI] 1...
December 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29089349/thyroid-function-and-the-risk-of-atherosclerotic-cardiovascular-morbidity-and-mortality-the-rotterdam-study
#11
Arjola Bano, Layal Chaker, Francesco U S Mattace-Raso, Aad van der Lugt, M Arfan Ikram, Oscar H Franco, Robin P Peeters, Maryam Kavousi
RATIONALE: Thyroid hormones have been linked with various proatherogenic and antiatherogenic processes. However, the relationship of thyroid function with manifestations of atherosclerosis remains unclear. OBJECTIVE: To investigate the association of thyroid function with atherosclerosis throughout its spectrum; that is, subclinical atherosclerosis, incident atherosclerotic cardiovascular (ASCV) events, and ASCV mortality. METHODS AND RESULTS: This population-based study was embedded within the Rotterdam Study...
December 8, 2017: Circulation Research
https://www.readbyqxmd.com/read/29081800/relationship-between-subclinical-thyroid-dysfunction-and-the-risk-of-cardiovascular-outcomes-a-systematic-review-and-meta-analysis-of-prospective-cohort-studies
#12
REVIEW
Jing Sun, Liang Yao, Yuan Fang, Ruifei Yang, Yaolong Chen, Kehu Yang, Limin Tian
BACKGROUND: Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting. METHODS AND RESULTS: PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies were included for meta-analysis. We found that subclinical hypothyroidism was not correlated with coronary heart disease (CHD) (RR = 1.17; 95% CI, 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29023926/hyperthyroidism-in-patients-with-ischaemic-heart-disease-after-iodine-load-induced-by-coronary-angiography-long-term-follow-up-and-influence-of-baseline-thyroid-functional-status
#13
Nadia Bonelli, Ruth Rossetto, Davide Castagno, Matteo Anselmino, Francesca Vignolo, Mirko Parasiliti Caprino, Fiorenzo Gaita, Ezio Ghigo, Roberto Garberoglio, Roberto Grimaldi, Mauro Maccario
OBJECTIVE: To study the effect of a iodine load on thyroid function of patients with ischaemic heart disease (IHD) and the long-term influence of unknown subclinical hyperthyroidism. CONTEXT: Subclinical hyperthyroidism is considered an independent risk factors for cardiovascular morbidity of patients with IHD. They routinely undergo coronary angiography with iodine contrast media (ICM) which may induce or even worsen hyperthyroidism. DESIGN: A cross-sectional study followed by a longitudinal study on patients with subclinical hyperthyroidism...
February 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/28910237/effects-of-once-weekly-exenatide-on-cardiovascular-outcomes-in-type-2-diabetes
#14
RANDOMIZED CONTROLLED TRIAL
Rury R Holman, M Angelyn Bethel, Robert J Mentz, Vivian P Thompson, Yuliya Lokhnygina, John B Buse, Juliana C Chan, Jasmine Choi, Stephanie M Gustavson, Nayyar Iqbal, Aldo P Maggioni, Steven P Marso, Peter Öhman, Neha J Pagidipati, Neil Poulter, Ambady Ramachandran, Bernard Zinman, Adrian F Hernandez
BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke...
September 28, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28867263/effects-of-hyperthyroidism-on-coronary-artery-disease-a%C3%A2-computed-tomography-angiography-study
#15
Christoph Beyer, Fabian Plank, Guy Friedrich, Matthias Wildauer, Gudrun Feuchtner
BACKGROUND: Changes in thyroid hormone concentration can negatively affect the cardiovascular system. Subclinical hyperthyroidism has been linked to an increase of cardiovascular heart disease, however, clinical effects and significance are still uncertain. Therefore, we analyzed coronary computed tomography angiographies of patients with overt and subclinical hyperthyroidism for quantitative parameters and plaque morphology. METHODS: Seven hundred forty-four (47...
October 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28862752/thyroid-stimulating-hormone-and-risk-of-sudden-cardiac-death-total-mortality-and-cardiovascular-morbidity
#16
Ville L Langén, Teemu J Niiranen, Pauli Puukka, Arttu O Lehtonen, Jussi A Hernesniemi, Jouko Sundvall, Veikko Salomaa, Antti M Jula
BACKGROUND: Previous data on the association of thyroid function with total mortality, cardiovascular disease (CVD) outcomes and sudden cardiac death (SCD) are conflicting or limited. We investigated associations of thyroid-stimulating hormone (TSH) with these outcomes in a nationwide population-based prospective cohort study. METHODS: We examined 5211 participants representative of the Finnish population aged ≥30 years in 2000-2001 and followed them for a median of 13...
January 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/28712563/trends-in-comorbidity-in-patients-hospitalised-for-cardiovascular-disease
#17
Josefien Buddeke, Michiel L Bots, Ineke van Dis, Anho Liem, Frank L J Visseren, Ilonca Vaartjes
BACKGROUND: We determined trends over time in cardiovascular and non-cardiovascular comorbidity in patients hospitalised for cardiovascular disease (CVD). METHODS: The Dutch nationwide hospital register was used to identify patients hospitalised for CVD during 2000-2010. Comorbidity was defined as a previous hospital admission for CVD other than the index CVD, cancer, diabetes, musculoskeletal and connective tissue disorders, respiratory disorders, thyroid gland disorders, kidney disorders and dementia in the five years previous to hospital admittance for the index CVD...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28670530/myopathy-in-patients-taking-atorvastatin-a-pilot-study
#18
K Manoj, N Jain, S V Madhu
AIM: This study aims to investigate the prevalence and risk factors of statin-induced myopathy. SUBJECTS AND METHODS: A total of 200 patients aged ≥ 40 years and taking atorvastatin 10 mg/day or more for at least 2 weeks were recruited in the study. A detailed history of participants and anthropometry of study participants was recorded, and features of myopathy were explained. Biochemical investigations along with thyroid stimulating hormone (TSH) and Vitamin D were done in all patients...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28620573/clinical-characteristics-and-outcomes-of-patients-with-ischemic-and-non-ischemic-complete-heart-block
#19
Murtaza Sundhu, Mehmet Yildiz, Mubbasher Syed, Bhavan Shah, Sajjad Gul, Omer Afzal, Lon Castle
INTRODUCTION: Third degree or complete heart block (CHB) is a medical emergency and usually requires permanent pacemaker placement. CHB can be caused by cardiac ischemia or non-ischemic conditions such as infiltrative diseases or fibrosis. The purpose of this study is to identify the baseline clinical characteristics associated with ischemic versus non-ischemic causes of complete heart block and compare their outcomes. MATERIALS AND METHODS: An institutional review broad approval was granted by the Cleveland Clinic Health System...
May 12, 2017: Curēus
https://www.readbyqxmd.com/read/28525397/an-unusual-case-of-sudden-death-is-there-a-relationship-between-thyroid-disorders-and-fatal-pulmonary-thromboembolism-a-case-report-and-review-of-literature
#20
REVIEW
Isabella Aquila, Silvia Boca, Fiorella Caputo, Matteo A Sacco, Santo Gratteri, Vittorio Fineschi, Pietrantonio Ricci
In adults, the most common cause of sudden death is coronary heart disease or defects in the cardiac conduction system; however, there are many cases of sudden death occurring from other causes such as fatal pulmonary thromboembolism. Several risk factors are recognized, including hospitalization, surgery, obesity, pregnancy, the use of oral contraceptives, traumatic fractures, and genetic conditions, which cause hypercoagulable states such as factor V Leiden mutations. Although many risk factors have been identified, the mortality rate is still high...
September 2017: American Journal of Forensic Medicine and Pathology
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