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https://www.readbyqxmd.com/read/28214530/automaton-model-of-protein-dynamics-of-conformational-and-functional-states
#1
REVIEW
Andrei Khrennikov, Ekaterina Yurova
In this conceptual paper we propose to explore the analogy between ontic/epistemic description of quantum phenomena and interrelation between dynamics of conformational and functional states of proteins. Another new idea is to apply theory of automata to model the latter dynamics. In our model protein's behavior is modeled with the aid of two dynamical systems, ontic and epistemic, which describe evolution of conformational and functional states of proteins, respectively. The epistemic automaton is constructed from the ontic automaton on the basis of functional (observational) equivalence relation on the space of ontic states...
February 15, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28205086/-agonism-and-antagonism
#2
Anne-Lise Rey
This essay considers dissensus as the starting point for the construction of a common epistemic space rather than as the acknowledgement of an irreducible disagreement. In the argumentative confrontation and disagreements, we do not want to identify a process which might lead to agreement through rational debate. The aim of this essay is rather to understand how dissensus leads to the constitution of plural communities. It discusses a certain number of texts of political philosophy (Habermas, Mouffe, etc.), where the notion of agreement is crucial to an analysis of argumentative confrontations...
December 2016: Revue de Synthèse
https://www.readbyqxmd.com/read/28195029/the-problem-of-epistemic-jurisdiction-in-global-governance-the-case-of-sustainability-standards-for-biofuels
#3
David E Winickoff, Matthieu Mondou
While there is ample scholarly work on regulatory science within the state, or single-sited global institutions, there is less on its operation within complex modes of global governance that are decentered, overlapping, multi-sectorial and multi-leveled. Using a co-productionist framework, this study identifies 'epistemic jurisdiction' - the power to produce or warrant technical knowledge for a given political community, topical arena or geographical territory - as a central problem for regulatory science in complex governance...
February 2017: Social Studies of Science
https://www.readbyqxmd.com/read/28195025/the-depth-of-fields-managing-focus-in-the-epistemic-subcultures-of-mind-and-brain-science
#4
David Peterson
The 'psy' sciences emerged from the tangled roots of philosophy, physiology, biology and medicine, and these origins have produced heterogeneous fields. Scientists in these areas work in a complex, overlapping ecology of fields that results in the constant co-presence of dissonant theories, methods and research objects. This raises questions regarding how conceptual clarity is maintained. Using the optical metaphor 'depth of field', I show how researchers in all fields marginalize potential threats to routine scientific work by framing them as either too broad and imprecise or too narrow and technical...
February 2017: Social Studies of Science
https://www.readbyqxmd.com/read/28184321/epistemic-injustice-or-safety-first
#5
Manhal M Zarroug, Dieneke Hubbeling, Robert Bertram
No abstract text is available yet for this article.
February 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28181069/quality-of-life-and-uncertainty-in-crohn-s-disease
#6
Galia Niv, Simona Bar Josef, Ofer Ben Bassat, Irit Avni, Lev Lictenstein, Yaron Niv, Sivia Barnoy
INTRODUCTION: Crohn's disease impairs patients' perception of health and has a negative impact on health-related quality of life. Although it is apparent that uncertainty is a significant factor that decreases quality of life, it has never been studied in patients with Crohn's disease. The objective of the present study was to examine the association between level of certainty, self-epistemic authority, Internet information gathering habits, and health-related quality of life. METHODS: A cross-sectional study of 105 Crohn's disease patients was conducted...
February 8, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28171816/the-western-disease-autism-and-somali-parents-embodied-health-movements
#7
Claire Laurier Decoteau
There is some statistical evidence indicating that Somali refugees and immigrants have high rates of autism spectrum disorder (ASD). Somalis in North America call autism the "Western disease" because there is no word for autism in the Somali language and because many believe it does not exist in Somalia. In Toronto, Somali parents have forged an "epistemic community," united around a coherent theory of the development of autism, its defining features, and most successful therapies. They work together with researchers to support the theory that gut bacteria is a causal factor for the development of autism...
February 1, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28167340/knowledge-and-power-in-policy-making-for-child-survival-in-niger
#8
Sarah L Dalglish, Daniela C Rodríguez, Abdoutan Harouna, Pamela J Surkan
Calls to enhance the use of scientific evidence in international health and development policy have increased in recent years; however, analytic frameworks for understanding evidence use focus on narrowly scientific research and were created using data and observations nearly exclusively from Western countries. We examine processes of health policy development in a case study of Niger, a low-income West African country that adopted integrated community case management of childhood illness (iCCM) beginning in 2007, resulting in measurable declines in child mortality...
January 30, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28163654/epistemic-cultures-in-complementary-medicine-knowledge-making-in-university-departments-of-osteopathy-and-chinese-medicine
#9
Caragh Brosnan
There is increasing pressure on complementary and alternative medicine (CAM) to follow the evidence-based approach promoted in allied health and medicine, in which the randomised control trial represents the evidence gold standard. However, many CAM advocates see these methods as undermining the holism of CAM practice. This paper explores how such tensions are managed in CAM university departments - settings in which particular forms of knowledge and evidence are given 'official' imprimatur by CAM educators and researchers...
May 3, 2016: Health Sociology Review: the Journal of the Health Section of the Australian Sociological Association
https://www.readbyqxmd.com/read/28160293/epistemic-authority-and-genuine-ethical-controversies
#10
Adam James Roberts
In 'Professional Hubris and its Consequences', Eric Vogelstein claims that 'that there are no good arguments in favor of professional organizations taking genuinely controversial positions on issues of professional ethics'. In this response, I defend two arguments in favour of organisations taking such positions: that their stance-taking may lead to better public policy, and that it may lead to better practice by medical professionals. If either of those defences succeeds, then Vogelstein's easy path to his conclusion - that professional organisations should not take such stances - is blocked...
February 3, 2017: Bioethics
https://www.readbyqxmd.com/read/28130697/blobel-and-sabatini-s-beautiful-idea-visual-representations-of-the-conception-and-refinement-of-the-signal-hypothesis
#11
Michelle Lynne LaBonte
In 1971, Günter Blobel and David Sabatini proposed a novel and quite speculative schematic model to describe how proteins might reach the proper cellular location. According to their proposal, proteins destined to be secreted from the cell contain a "signal" to direct their release. Despite the fact that Blobel and Sabatini presented their signal hypothesis as a "beautiful idea" not grounded in experimental evidence, they received criticism from other scientists who opposed such speculation. Following the publication of the 1971 model, Blobel persisted in conducting experiments and revising the model to incorporate new data...
January 27, 2017: Journal of the History of Biology
https://www.readbyqxmd.com/read/28105637/preschoolers-continually-adjust-their-epistemic-trust-based-on-an-informant-s-ongoing-accuracy
#12
Samuel Ronfard, Jonathan D Lane
Children aged 4-7 years (N = 120) played four rounds of a find-the-sticker game. For each round, an informant looked into two cups and made a claim about which cup held a sticker. At the end of each round, children guessed the sticker's location, and then the sticker's actual location was revealed. For three of the rounds, the informant accurately reported the sticker's location. But critically, for one round-either Round 1, 2, or 3-she was inaccurate. Children continually adjusted their trust in the informant as they obtained more information about her accuracy...
January 20, 2017: Child Development
https://www.readbyqxmd.com/read/28104631/the-ethics-of-reporting-all-the-results-of-clinical-trials
#13
REVIEW
Iain Brassington
INTRODUCTION OR BACKGROUND: The terms 'publication bias' and 'reporting bias' describe aspects of a phenomenon by which data from trials are not publicized, and so remain inaccessible. This may generate a false impression about the world; but those facts may have important implications for clinical decisions. Thus, the bias may leave patients worse off than they might be. SOURCES OF DATA: Published journal articles. AREAS OF AGREEMENT: There is general agreement that the phenomenon happens, and that to the extent that it happens, it is undesirable for moral rather than simply epistemic reasons...
January 18, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28100294/why-do-we-remember-the-communicative-function-of-episodic-memory
#14
Johannes Mahr, Gergely Csibra
Episodic memory has been analyzed in a number of different ways in both philosophy and psychology, and most controversy has centered on its self-referential, 'autonoetic' character. Here, we offer a comprehensive characterization of episodic memory in representational terms, and propose a novel functional account on this basis. We argue that episodic memory should be understood as a distinctive epistemic attitude taken towards an event simulation. On this view, episodic memory has a metarepresentational format and should not be equated with beliefs about the past...
January 19, 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28090729/notes-on-the-use-of-randomised-controlled-trials-to-evaluate-complex-interventions-community-treatment-orders-as-an-illustrative-case
#15
Feras Ali Mustafa
Over the past seven decades, randomised controlled trials (RCTs) have revolutionised clinical research and achieved a gold standard status. However, extending their use to evaluate complex interventions is problematic. In this paper we will demonstrate that complex intervention RCTs violate the necessary premises that govern the RCTs logic and underpin their rigour. The lack of blinding, heterogeneity of participants, as well as poor treatment standardisation and difficulty of controlling for confounders, which characterise complex intervention RCTs, can potentially be profoundly detrimental to their integrity...
January 16, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28079497/meanings-of-waves-electroencephalography-and-society-in-mexico-city-1940-1950
#16
Nuria Valverde Pérez
Argument This paper focuses on the uses of electroencephalograms (EEGs) in Mexico during their introductory decade from 1940 to 1950. Following Borck (2006), I argue that EEGs adapted to fit local circumstances and that this adjustment led to the consolidation of different ways of making science and the emergence of new objects of study and social types. I also maintain that the way EEGs were introduced into the institutional networks of Mexico entangled them in discussions about the objective and juridical definitions of social groups, thereby preempting concerns about their technical and epistemic limitations...
December 2016: Science in Context
https://www.readbyqxmd.com/read/28064257/epistemic-cognition-in-medical-education-a-literature-review
#17
REVIEW
Jennifer L Eastwood, Elysa Koppelman-White, Misa Mi, Jason Adam Wasserman, Ernest F Krug Iii, Barbara Joyce
Objective: To review the research literature on epistemic cognition in medical education. Methods: We conducted database searches using keywords related to epistemic cognition and medical education or practice. In duplicate, authors selected and reviewed empirical studies with a central focus on epistemic cognition and participant samples including medical students or physicians. Independent thematic analysis and consensus procedures were used to identify major findings about epistemic cognition and implications for research and medical education...
January 7, 2017: International Journal of Medical Education
https://www.readbyqxmd.com/read/28056721/controlling-new-knowledge-genomic-science-governance-and-the-politics-of-bioinformatics
#18
Brian Salter, Charlotte Salter
The rise of bioinformatics is a direct response to the political difficulties faced by genomics in its quest to be a new biomedical innovation, and the value of bioinformatics lies in its role as the bridge between the promise of genomics and its realization in the form of health benefits. Western scientific elites are able to use their close relationship with the state to control and facilitate the emergence of new domains compatible with the existing distribution of epistemic power - all within the embrace of public trust...
January 1, 2017: Social Studies of Science
https://www.readbyqxmd.com/read/28053164/the-papillomavirus-episteme-a-major-update-to-the-papillomavirus-sequence-database
#19
Koenraad Van Doorslaer, Zhiwen Li, Sandhya Xirasagar, Piet Maes, David Kaminsky, David Liou, Qiang Sun, Ramandeep Kaur, Yentram Huyen, Alison A McBride
The Papillomavirus Episteme (PaVE) is a database of curated papillomavirus genomic sequences, accompanied by web-based sequence analysis tools. This update describes the addition of major new features. The papillomavirus genomes within PaVE have been further annotated, and now includes the major spliced mRNA transcripts. Viral genes and transcripts can be visualized on both linear and circular genome browsers. Evolutionary relationships among PaVE reference protein sequences can be analysed using multiple sequence alignments and phylogenetic trees...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28027705/parachemistries-colonial-chemopolitics-in-a-zone-of-contest
#20
Projit Bihari Mukharji
The globalization of modern chemistry through European colonialism resulted, by the end of the nineteenth century, in the emergence of a number of parachemical knowledges. Parachemistries were bodies of non-European knowledge which came to be related to modern chemistry within particular historical milieux. Their relationship with modern chemistry was not necessarily epistemic and structural, but historical and performative. Actual historically located intellectuals posited their relationship. Such relationships were not merely abstract intellectual exercises; at a time when the practical uses of modern chemistry in statecraft were growing, the existence of these rival, competing parachemical knowledges challenged modern chemistry's regulatory deployments...
December 2016: History of Science; An Annual Review of Literature, Research and Teaching
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