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https://www.readbyqxmd.com/read/28938412/renal-metabolic-programming-is-linked-to-the-dynamic-regulation-of-a-leptin-klf15-axis-and-akt-ampk%C3%AE-signaling-in-male-offspring-of-obese-dams
#1
Philipp Kasper, Christina Vohlen, Katharina Dinger, Jasmine Mohr, Eva Hucklenbruch-Rother, Ruth Janoschek, Jessica Köth, Jan Matthes, Sarah Appel, Jörg Dötsch, Miguel A Alejandre Alcazar
Childhood obesity is associated with renal diseases. Maternal obesity is a risk factor linked to increased adipocytokines and metabolic disorders in the offspring. We therefore studied the impact of maternal obesity on renal-intrinsic insulin and adipocytokine signaling and on renal function and structure. To induce maternal obesity female mice were fed with high-fat diet (HFD) or standard diet (SD, Co) prior to mating, during gestation and throughout lactation. A third group of dams was fed HFD only during lactation (HFD-Lac)...
July 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938340/paediatric-traumatic-brain-injury-prognostic-insights-and-outlooks
#2
Alicia K Au, Robert S B Clark
PURPOSE OF REVIEW: Traumatic brain injury (TBI) is a leading cause of death and disability in children. Prognostication of outcome following TBI is challenging in this population and likely requires complex, multimodal models to achieve clinically relevant accuracy. This review highlights injury characteristics, physiological indicators, biomarkers and neuromonitoring modalities predictive of outcome that may be integrated for future development of sensitive and specific prognostic models...
September 21, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28938335/statistical-analysis-of-influences-on-the-psychosocial-status-of-children-with-hemangiomas-and-their-families
#3
Ji Ung Park, Soohee Kang, Tae Hyun Choi
The psychologic stress on the child and family, which arise from hemangiomas, the most common neoplasm of childhood, cannot be overestimated. This study determined the preoperative and postoperative psychosocial status and variation among Oriental children with hemangiomas and their families by questionnaire. Thirty patients who underwent surgery for hemangiomas were assessed for preoperative and postoperative psychosocial status by questionnaire. The distribution of the total mean score and variation between the preoperative and postoperative status was estimated...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938322/the-relationship-of-the-temporal-branch-of-the-facial-nerve-to-the-fascial-planes-of-temporal-region-in-human-fetuses
#4
Özlem Elvan, Alev Bobuş Kara, Mesut Sabri Tezer, Mustafa Aktekin
The aim of this study was to obtain information by assessing the relationship between temporal region fascial structures, fat pads, and temporal branches of facial nerve in human fetuses to use the knowledge on treatment of early childhood period surgeries. This anatomic dissection study was conducted on 40 hemifaces with no visible external abnormalities on their faces. Fascial layers and related fat pads of temporal region were dissected layer by layer beginning from superficial to deep. The relations of temporal branches of facial nerve and temporoparietal fascia and the structures of these fascial layers were evaluated...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938260/cryptosporidium-species-are-frequently-present-but-rarely-detected-in-clinical-samples-from-children-with-diarrhea-in-a-developed-country
#5
Daniel M Skovgaards, Gitte N Hartmeyer, Marianne N Skov, Silje V Hoegh, Michael Kemp
Two studies were done on cryptosporidiosis in children. A retrospective survey showed that from 2005 to 2015 Cryptosporidium species was detected by microscopy of stool from 0.25% of children with diarrhea. In a subsequent prospective study PCR detected Cryptosporidium species in 4 (1,3%) of 304 children. Cryptosporidium species is as frequent as other intestinal pathogens in childhood diarrhea. Testing is relevant.
September 20, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28938257/childhood-visceral-leishmaniasis-distinctive-features-and-diagnosis-of-a-re-emerging-disease-an-11-year-experience-from-a-tertiary-referral-center-in-athens-greece
#6
Panagiotis Krepis, Adamantia Krepi, Ioanna Argyri, Anastasios Aggelis, Alexandra Soldatou, Maria Tsolia
BACKGROUND: Visceral leishmaniasis (VL) remains a public health issue in Greece. The aim of this study was to describe the clinical and epidemiological characteristics of pediatric VL in our region as well as to evaluate the laboratory findings and the diagnostic techniques that are applied. METHODS: We retrospectively reviewed the medical records of all children diagnosed with VL in an 11-year period at a tertiary public hospital in the region of Athens. Demographic features, clinical information and laboratory findings were accessed...
September 20, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28937949/international-vision-care-issues-and-approaches
#7
Rohit C Khanna, Srinivas Marmamula, Gullapalli N Rao
Globally, 32.4 million individuals are blind and 191 million have moderate or severe visual impairment (MSVI); 80% of cases of blindness and MSVI are avoidable. However, great efforts are needed to tackle blindness and MSVI, as eye care in most places is delivered in isolation from and without significant integration with general health sectors. Success stories, including control of vitamin A deficiency, onchocerciasis, and trachoma, showed that global partnerships, multisectoral collaboration, public-private partnerships, corporate philanthropy, support from nongovernmental organizations-both local and international-and governments are responsible for the success of these programs...
September 15, 2017: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28937904/periodontal-pathogen-colonization-in-young-children-by-pcr-quantification-a-longitudinal-survey
#8
Karine Takahashi, Robson Frederico Cunha, Elerson Gaetti Jardim Junior
INTRODUCTION: Periodontal diseases are among the leading causes of premature tooth loss in adults, but the microbiota associated with this problem is established over time in childhood. AIM: This longitudinal study aimed to verify the occurrence of periodontal pathogens in the oral cavity of children aged six, twelve, eighteen and twenty-four months through PCR quantification, correlating them with the oral microbiota of their mothers. STUDY DESIGN: Saliva and oral biofilm samples were collected from mothers and children by using sterilized paper points...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937896/evaluation-of-oral-health-related-quality-of-life-to-assess-dental-treatment-in-preschool-children-with-early-childhood-caries-a-preliminary-study
#9
Ana Lúcia Vollú, Maria da Encarnação Perez Requejo da Costa, Lucianne Cople Maia, Andréa Fonseca-Gonçalves
PURPOSE: The oral health-related quality of life (OHRQoL) of preschool children with Early Childhood Caries (ECC) was used to assess the outcome of dental treatment. STUDY DESIGN: Children (3.56±1.31years) affected by ECC were selected. Anamnesis, clinical and radiographic exams were performed. Data about sociodemographic aspects, OHRQoL and dmf-t index were collected. The Brazilian version of Early Childhood Oral health Impact Scale (B-ECOHIS) was applied in two time intervals: before and after 30 days of treatment...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937639/sleep-disorders-in-childhood-neurological-diseases
#10
REVIEW
Abdullah Tolaymat, Zhao Liu
Sleep problems are frequently addressed as a primary or secondary concern during the visit to the pediatric neurology clinic. Sleep disorders can mimic other neurologic diseases (e.g., epilepsy and movement disorders), and this adds challenges to the diagnostic process. Sleep disorders can significantly affect the quality of life and functionality of children in general and those with comorbid neurological diseases in particular. Understanding the pathophysiology of sleep disorders, recognizing the implications of sleep disorder in children with neurologic diseases and behavioral difficulties, and early intervention continue to evolve resulting in better neurocognitive outcomes...
September 22, 2017: Children
https://www.readbyqxmd.com/read/28937552/naspghan-clinical-report-on-postoperative-recurrence-in-pediatric-crohn-disease
#11
Judy B Splawski, Marian D Pffefferkorn, Marc E Schaefer, Andrew S Day, Oliver S Soldes, Todd A Ponsky, Philip Stein, Jess L Kaplan, Shehzad A Saeed
Pediatric Crohn disease is characterized by clinical and endoscopic relapses. The inflammatory process is considered to be progressive and may lead to strictures, fistulas, and penetrating disease that may require surgery. In addition, medically refractory disease may be treated by surgical resection of inflamed bowel in an effort to reverse growth failure. The need for surgery in childhood suggests severe disease and these patients have an increased risk for recurrent disease and potentially more surgery. Data show that up to 55% of patients had clinical recurrence in the first 2 years after initial surgery...
October 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28937521/ominous-trends-in-childhood-cancer-mortality-who-was-right
#12
Richard J Q McNally, Peter W James, Alan W Craft
No abstract text is available yet for this article.
October 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28937508/status-dystonicus-in-childhood
#13
Daniel E Lumsden, Mary D King, Nicholas M Allen
PURPOSE OF REVIEW: Dystonia is a common paediatric neurological condition. At its most severe, dystonia may lead to life-threatening complications, a state termed status dystonicus. This review provides an update on the definition, causes, management and outcome of childhood status dystonicus. RECENT FINDINGS: High-quality studies in childhood status dystonicus are lacking, though an increasing number of case series have been published. Status dystonicus appears to occur more frequently in children compared with adults, with a clear precipitant identified in around two-thirds of cases...
September 20, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28937468/psychogenic-low-back-pain-and-hysterical-paralysis-in-adolescence
#14
Tsukasa Kanchiku, Hidenori Suzuki, Yasuaki Imajo, Yuichiro Yoshida, Norihiro Nishida, Toshihiko Taguchi
STUDY DESIGN: A retrospective review. OBJECTIVE: The purpose of this study was to investigate the clinical outcomes in adolescents diagnosed with psychogenic low-back pain and hysterical paralysis and to evaluate the efficacy of differential diagnosis methods. SUMMARY OF BACKGROUND DATA: The incidence of low-back pain in adolescence is similar to that in adults, but the causes of low-back pain are difficult to determine in most cases. For these patients, a definitive diagnosis of psychogenic low-back pain and hysterical paralysis as well as adequate treatment are clinically important to avoid unnecessary surgical treatment...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937467/does-the-prevalence-of-spondylolysis-and-spina-bifida-occulta-observed-in-pediatric-patients-remain-stable-in-adults
#15
Julio Urrutia, Tomas Zamora, Jorge Cuellar
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To compare the prevalence of lumbar spondylolysis and spina bifida occulta (SBO) in pediatric and adult populations. SUMMARY OF BACKGROUND DATA: The prevalence of spondylolysis reported from radiograph-based studies in children had been questioned in computed tomography (CT)-based studies in adults; however, a recent CT-based study in pediatric patients has confirmed the previously reported data in pediatric populations...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937451/cognitive-and-psychosocial-functioning-of-preschool-aged-children-with-cancer
#16
Victoria W Willard, Lauren E Cox, Kathryn M Russell, Ansley Kenney, Niki Jurbergs, Andrew E Molnar, Jennifer L Harman
OBJECTIVE: Most children with cancer are diagnosed in early childhood, potentially resulting in missed developmental opportunities. The most common diagnoses-brain tumors, leukemia-are also associated with increased risk of neurocognitive deficits. Unfortunately, research regarding the functioning of preschool-aged children with cancer is limited. Our objective is to describe the cognitive and psychosocial functioning of preschool-aged children with cancer who completed a clinical evaluation at a hospital-based psychology clinic...
September 19, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28937417/age-related-changes-in-ocular-aberrations-and-the-yamagata-study-funagata
#17
Hiroyuki Namba, Ryo Kawasaki, Akira Sugano, Takanori Murakami, Koichi Nishitsuka, Takeo Kato, Takamasa Kayama, Hidetoshi Yamashita
Human vision quality is influenced by ocular aberrations, including astigmatism and higher-order aberrations (HOAs), in combination with other optical factors. In this study, we introduce the results and perceptions of previous studies investigating these aberrations. We also introduce our results obtained as part of the Yamagata Study (Funagata), a population-based epidemiologic study. To investigate the astigmatic change with age, researchers have used the power vector analysis, allowing incorporation of the magnitude and axis of astigmatism into statistical analyses...
September 19, 2017: Cornea
https://www.readbyqxmd.com/read/28937086/pulmonary-thromboembolism-as-first-presentation-of-childhood-membranous-nephropathy
#18
Mohit Madken, Shankar Prasad Nagaraju, Ravindra Prabhu Attur, Mahesha Vankalakunti
Nephrotic syndrome is associated with an increased risk of thromboembolism. Pulmonary thromboembolism has been described in nephrotic syndrome with or without deep vein thrombosis. In this case report, we describe an unusual first presentation of childhood membranous nephropathy with massive pulmonary thrombus with pulmonary infarction with right renal vein thrombosis.
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28937057/outcome-of-childhood-lupus-nephritis-in-saudi-children
#19
Sulaiman Mohammed Al-Mayouf, Ali AlAmeer, Areej Alfattani, Abdullah Alsonbul
Our aim in this study is to report the long-term renal outcome of a cohort of Saudi children with systemic lupus erythematosus (SLE). All patients with childhood lupus nephritis (cLN) proved by renal biopsy seen between January 2000 and June 2015 were reviewed. The renal outcome was assessed according to serum creatinine level, protein/creatinine ratio at the last follow-up visit, and/or evidence of renal impairment during follow-up period and end-stage renal disease (ESRD). Additional outcome measures include accrual damage measured by pediatric adaptation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (pSDI), and death related to SLE was determined...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28936881/quality-indicators-in-pediatric-colonoscopy-an-australian-tertiary-center-experience
#20
H K Singh, G D Withers, L C Ee
OBJECTIVES: Quality indicators for colonoscopy in adults are largely driven by colorectal cancer screening, and include cecal intubation rates, with rates of >90% recommended. In contrast, colorectal cancer is rare in childhood, with paucity of data on relevant quality indicators for pediatric colonoscopy. It is also unclear whether high rates of cecal intubation are achievable in small children. Our aim was to audit all colonoscopies performed in a tertiary pediatric center to examine clinical indications for procedure, completeness of examination with cecal and ileal intubation, significant findings, and complications...
September 22, 2017: Scandinavian Journal of Gastroenterology
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