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https://www.readbyqxmd.com/read/28724023/-maternal-depressive-symptoms-and-anxiety-and-interference-in-the-mother-child-relationship-based-on-a-prenatal-cohort-an-approach-with-structural-equations-modeling
#1
Adriana Oliveira Dias de Sousa Morais, Vanda Maria Ferreira Simões, Lívia Dos Santos Rodrigues, Rosângela Fernandes Lucena Batista, Zeni Carvalho Lamy, Carolina Abreu de Carvalho, Antônio Augusto Moura da Silva, Marizélia Rodrigues Costa Ribeiro
This study aimed to investigate the association between maternal depressive symptoms and anxiety and interference in the mother/child relationship, using structural equations modeling. Data were used from a prospective cohort study initiated during the prenatal period with 1,140 mothers in São Luís, Maranhão State, Brazil. Data were collected during prenatal care and when the children reached two years of age. Interference in the mother/child relationship was measured with the Postpartum Bonding Questionnaire - PBQ (N = 1,140)...
July 13, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28723827/neurocognitive-and-symptom-trajectories-of-adhd-from-childhood-to-early-adolescence
#2
Andrea L Murray, Thomas Robinson, Gail Tripp
OBJECTIVE: This longitudinal study investigated changes in neurocognitive functioning from childhood to early adolescence in a sample of children diagnosed with DSM-IV attention-deficit hyperactivity disorder (ADHD). It also compared the neurocognitive trajectories of children who continued to meet the diagnostic criteria for ADHD at follow-up and those in partial remission. METHODS: Children diagnosed with ADHD (N = 55) were tested at baseline (M = 7.7 years, SD = 1...
July 17, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28723823/association-between-television-viewing-and-parent-child-reading-in-the-early-home-environment
#3
Kiren S Khan, Kelly M Purtell, Jessica Logan, Arya Ansari, Laura M Justice
OBJECTIVE: This study examines whether there is an association between time spent by preschoolers in parent-child shared book reading versus TV viewing in two distinct samples. METHODS: Data were used from both the preschool wave of the Early Childhood Longitudinal Study Cohort, a nationally representative sample of 4-year-olds (N = 8900), as well as a low-income, rural sample of children enrolled in the Preschool Experience in Rural Classrooms study (N = 407). Information regarding frequency of shared book reading and daily TV consumption was obtained through caregiver report...
July 14, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28723818/somatotype-and-body-composition-in-young-soccer-players-according-to-the-playing-position-and-sport-success
#4
Víctor Cárdenas-Fernández, José Luis Chinchilla-Minguet, Alfonso Castillo-Rodríguez
Soccer players undergo an evolution in their body composition throughout the growth and passage through the different base stages, that is, childhood, puberty and adolescence. The aim of this study was to analyze the morphology and body composition of U14, U16, and U19 soccer players, taking into account in addition, their sport success endorsed through the regularity participation and their relation with the different playing positions occupied during competition (goalkeeper, external defender, central defender, midfielder and forward/extreme)...
July 17, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28723766/lady-with-wings-a-case-report-of-giant-neurofibromatosis-type-i
#5
Suraj Maharjan, Xiucun Li, Jianli Cui, Yang Liu, Laijin Lu
RATIONALE: Neurofibromatosis type I (NF-I) accounts for approximately 90% of neurofibromatosis. NF-I is an autosomal dominant genetic disease which results from the gene mutation of NF-I situated in chromosome 17q11.2. PATIENT CONCERNS: A 32-year-old lady presented with a giant wing like structure on her back which started growing from her childhood. DIAGNOSIS: A diagnosis of NF-I was confirmed as she presented with multiple cutaneous nodules, multiple café-au-lait macules of different sizes, scoliosis deformity, and positive family history of neurofibroma...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723704/trends-and-territorial-inequalities-of-incidence-and-survival-of-childhood-leukaemia-and-their-relations-to-socioeconomic-status-in-hungary-1971-2015
#6
Zsuzsanna Jakab, Attila Juhasz, Csilla Nagy, Dezso Schuler, Miklos Garami
The Hungarian Childhood Cancer Registry, a population-based national registry of the Hungarian Paediatric Haemato-Oncology Network founded in 1971, monitors the incidence and mortality of childhood cancer. Our aims were to carry out a longitudinal study to investigate the trends and spatial inequalities of incidence and survival of leukaemia, and the association between survival and deprivation in Hungary. All cases of childhood leukaemia and myelodysplasia were analysed (3157 cases, 1971-2015, age: 0-14 years)...
July 18, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28723626/positive-correlation-of-cg16672562-methylation-with-obesity-related-traits-in-childhood-obesity-and-its-independence-with-underlying-hif3a-hypoxia-inducible-factor-3a-genetic-background
#7
Suman Lee, Hyo Jin Kim, Sohee Han, Jae-Pil Jeon, Sang-Ick Park, Ho-Yeong Yu, Mi Yeong Hwang, Juyoung Lee
Differential methylations of the HIF3A (hypoxia-inducible factor 3a) gene have been linked to body mass index (BMI). To explore the association of these methylations to childhood obesity, we measured 5 CpG methylation sites (cg27146050, cg46801562, cg22891070, cg16672562 and cg46801675) in intron 1 of the HIF3A gene by pyrosequencing, in the Korean population (mean age: 13.9 yrs, 305 obese cases and 387 controls). Two CpG methylations, cg46801562 and cg16672562, had statistically significant association with childhood obesity (P = 2...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723622/dual-targeting-of-mdm2-and-bcl2-as-a-therapeutic-strategy-in-neuroblastoma
#8
Alan Van Goethem, Nurten Yigit, Myrthala Moreno-Smith, Sanjeev A Vasudevan, Eveline Barbieri, Frank Speleman, Jason Shohet, Jo Vandesompele, Tom Van Maerken
Wild-type p53 tumor suppressor activity in neuroblastoma tumors is hampered by increased MDM2 activity, making selective MDM2 antagonists an attractive therapeutic strategy for this childhood malignancy. Since monotherapy in cancer is generally not providing long-lasting clinical responses, we here aimed to identify small molecule drugs that synergize with idasanutlin (RG7388). To this purpose we evaluated 15 targeted drugs in combination with idasanutlin in three p53 wild type neuroblastoma cell lines and identified the BCL2 inhibitor venetoclax (ABT-199) as a promising interaction partner...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723611/parent-reported-nutritional-risk-and-laboratory-indices-of-cardiometabolic-risk-and-in-preschool-aged-children
#9
Navindra Persaud, Hedyeh Ziai, Gerald Lebovic, Jonathon L Maguire, Marina Khovratovich, Janis A Randall Simpson, Khosrow Adeli, Jill Hamilton, Brian W McCrindle, Patricia C Parkin, Catherine S Birken
BACKGROUND: Eating habits formed during childhood may contribute to the increasing prevalence of cardiometabolic disorders. Assessing nutritional risk in young children may help to prevent later cardiometabolic disease. The objective of this study was to determine whether parent-reported nutritional risk in preschool-aged children was associated with laboratory indices of cardiometabolic risk, namely leptin and insulin. METHODS: In this cross-sectional study, the relationship between nutritional risk as determined by the parent-completed NutriSTEP® questionnaire was assessed and compared to the serum leptin and insulin concentrations, hormones involved in regulation of food intake and biomarkers of adiposity and cardiometabolic risk...
July 19, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28722763/isolated-drainage-of-right-superior-vena-cava-into-left-atrium-a%C3%A2-rare-etiology-of-childhood-central-cyanosis
#10
Shaimaa Rakha, Mohamed-Magdy Abuelkheir, Mohamed-Adel F Elgamal
Isolated right superior vena cava drainage into the left atrium (RSVC-LA) is an extremely rare anomaly in the absence of other cardiac or extracardiac abnormalities. The clinical and echocardiographic diagnosis is considered challenging. We report a female infant with cyanosis on crying who was diagnosed as isolated RSVC-LA using conventional and contrast echocardiography, but further confirmation was possible via multidetector CT. The surgical correction was performed with smooth postoperative recovery. In conclusion, isolated RSVC-LA must be in the differential diagnosis of cyanosis in the absence of intracardiac anomalies...
July 18, 2017: Echocardiography
https://www.readbyqxmd.com/read/28722694/early-life-vincristine-exposure-evokes-mechanical-pain-hypersensitivity-in-the-developing-rat
#11
Katie A Schappacher, Lauren Styczynski, Mark L Baccei
Vincristine (VNC) is commonly used to treat pediatric cancers, including the most prevalent childhood malignancy, acute lymphoblastic leukemia. Although clinical evidence suggests that VNC causes peripheral neuropathy in children, the degree to which pediatric chemotherapeutic regimens influence pain sensitivity throughout life remains unclear, in part because of the lack of an established animal model of chemotherapy-induced neuropathic pain during early life. Therefore, this study investigated the effects of VNC exposure between postnatal days (P) 11 and 21 on mechanical and thermal pain sensitivity in the developing rat...
May 30, 2017: Pain
https://www.readbyqxmd.com/read/28722691/structural-basis-of-bone-fragility-in-young-subjects-with-inflammatory-bowel-disease-a-high-resolution-pqct-study-of-the-swiss-ibd-cohort-sibdc
#12
Jessica Pepe, Sophie Zawadynski, Francois R Herrmann, Pascal Juillerat, Pierre Michetti, Sylvie Ferrari-Lacraz, Dominique Belli, Osman Ratib, René Rizzoli, Thierry Chevalley, Serge L Ferrari
BACKGROUND: The onset of inflammatory bowel disease (IBD) during childhood/adolescence compromises peak bone mass acquisition and predisposes to fractures later in life. However, the structural basis for bone fragility in young adults with IBD remains unknown. METHODS: One hundred two young subjects from the Swiss IBD cohort were included. Areal bone mineral density (aBMD) at distal radius, hip, and spine as well as morphometric vertebral fractures were assessed using dual-energy x-ray absorptiometry technique...
August 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28722581/epidemiology-of-diphtheria-in-india-1996-2016-implications-for-prevention-and-control
#13
Manoj Murhekar
Diphtheria is an acute disease caused by exotoxin-producing Corynebacterium diphtheriae. Globally, diphtheria has been showing a declining trend due to effective childhood vaccination programs. A substantial proportion of global burden of diphtheria is contributed by India. Hospital-based surveillance studies as well as diphtheria outbreaks published in last 20 years (1996-2016) indicate that diphtheria cases are frequent among school-going children and adolescents. In some Indian states, Muslim children are affected more...
June 26, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722570/mycobacterium-tuberculosis-infection-in-close-childhood-contacts-of-adults-with-pulmonary-tuberculosis-is-increased-by-secondhand-exposure-to-tobacco
#14
Ifedayo M O Adetifa, Lindsay Kendall, Simon Donkor, Moses D Lugos, Abdulrahman S Hammond, Patrick K Owiafe, Martin O C Ota, Roger H Brookes, Philip C Hill
Tobacco use is a major risk factor for tuberculosis (TB). Secondhand smoke (SHS) is also a risk factor for TB and to a lesser extent, Mycobacterium tuberculosis infection without disease. We investigated the added risk of M. tuberculosis infection due to SHS exposure in childhood contacts of TB cases in The Gambia. Participants were childhood household contacts aged ≤ 14 years of newly diagnosed pulmonary TB (PTB) cases. The intensity of exposure to the case was categorized according to whether contacts slept in the same room, same house, or a different house as the case...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722310/capitalizing-on-scientific-advances-to-improve-access-to-and-quality-of-children-s-mental-health-care
#15
Ann F Garland, Florencia Lebensohn-Chialvo, Kristopher G Hall, Erika R N Cameron
The majority of mental health problems begin in childhood or adolescence. The potential benefits of early identification and treatment of such problems are well established, and models of effective mental health interventions for children have proliferated in recent decades. However, barriers in access to care and challenges in assuring delivery of high-quality care significantly limit the public health impact of services for children and families. Specifically, the majority of children who need mental health care do not receive it, and when children are in care, many do not receive interventions that are most likely to have the greatest positive impact...
July 19, 2017: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/28722116/opioids-for-cancer-related-pain-in-children-and-adolescents
#16
REVIEW
Philip J Wiffen, Tess E Cooper, Anna-Karenia Anderson, Andrew L Gray, Marie-Claude Grégoire, Gustaf Ljungman, Boris Zernikow
BACKGROUND: Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization (WHO) guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. Views on children's pain have changed over time and relief of pain is now seen as important. In the past, pain was largely dismissed and was frequently left untreated, and it was assumed that children quickly forgot about painful experiences...
July 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28722101/-gilles-de-la-tourette-syndrome-symptoms-causes-and-therapy
#17
Ewgeni Jakubovski, Kirsten R Müller-Vahl
Gilles de la Tourette syndrome is a chronic neuropsychiatric movement disease with combined motor tics and at least one vocal tic for a minimum period of 1 year. It typically begins in the childhood (under 18 years of age).Most of the patients with Tourette syndrome have comorbidities, which often impair their quality of life more than the tics themselves.There are reported abnormalities in the cortico-striato-thalamo-cortical regions as well as in the neurotransmission of dopamine and other neurotransmission systems...
June 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28722079/physicians-experience-with-follow-up-care-of-childhood-cancer-survivors-challenges-and-needs
#18
Gisela Michel, Micol Eva Gianinazzi, Janine Vetsch, Luzius Mader, Judith E Lupatsch, Nicolas X von der Weid, Corina Silvia Rueegg
BACKGROUND: Regular follow-up care is essential for childhood cancer survivors, but we know little about physicians' experience with it. We aimed to describe: (1) involvement of Swiss physicians in follow-up care; (2) content of follow-up care provided; (3) problems encountered; and (4) additional resources needed. MATERIALS AND METHODS: Within this cross-sectional survey we sent adapted questionnaires via professional associations to a sample of medical oncologists (MOs), paediatric oncologists (POs), general practitioners (GPs) and paediatricians (P) in Switzerland...
July 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28721760/stroke-in-childhood
#19
Lynne Pearce
Essential facts About 400 children a year have a stroke in the UK. Many are left with severe disability. While there have been improvements in diagnosis and treatment in recent years, the condition is still not as well recognised as stroke in adults. Experts believe that greater awareness among parents and healthcare professionals could lead to speedier diagnosis and minimise risk of severe long-term health problems.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28721757/higher-childhood-intelligence-linked-to-longer-life
#20
(no author information available yet)
Higher intelligence in childhood is associated with lower lifetime risk of major causes of death, including heart disease, stroke, smoking-related cancers, respiratory disease and dementia.
July 19, 2017: Nursing Standard
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