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https://www.readbyqxmd.com/read/29759594/liquid-chromatography-mass-spectrometry-based-metabolomics-and-lipidomics-reveal-toxicological-mechanisms-of-bisphenol-f-in-breast-cancer-xenografts
#1
Chao Zhao, Peisi Xie, Hailin Wang, Zongwei Cai
Bisphenol F (BPF) is a major alternative to bisphenol (BPA) and has been widely used. Although BPA exposure is known to generate various toxic effects, toxicity of BPF remains under-explored. A comprehensive method involving mass spectrometry (MS)-based global lipidomics and metabolomics, and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI)- MS imaging (MSI) was used to study toxic effects of BPF and the underlying mechanisms on tumor metastasis-related tissues (liver and kidney) in breast cancer xenografts...
May 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29756685/evaluation-of-right-ventricular-myocardial-strains-by-speckle-tracking-echocardiography-after-percutaneous-device-closure-of-atrial-septal-defects-in-children
#2
Qiuqin Xu, Ling Sun, Wanping Zhou, Yunjia Tang, Yueyue Ding, Jie Huang, Hui Wang, Cui Hou, Haitao Lv
OBJECTIVES: The aim of this study was to clarify the influence of the ASD closure by occluder device on right ventricular acute and long-term changes in longitudinal systolic strains, by evaluating right ventricular wall deformation in children using speckle tracking echocardiography (STE). METHODS AND MATERIALS: We enrolled 30 children with ASDs and 40 controls in our study. The Amplatzer atrial defect occluder was used to close the ASDs. Transthoracic echocardiographic examinations were performed at 3 points in time: the day before closure, 1 day after closure, and 3 months after closure...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29754921/global-longitudinal-strain-corrected-by-rr-interval-is-a-superior-echocardiographic-predictor-of-outcome-in-patients-with-atrial-fibrillation
#3
Maria Dons, Jan Skov Jensen, Flemming Javier Olsen, Martina Chantal de Knegt, Thomas Fritz-Hansen, Ali Vazir, Tor Biering-Sørensen
BACKGROUND: Echocardiographic assessment of systolic and diastolic function during atrial fibrillation (AF) is challenging. This study evaluates the prognostic value of strain in patients with AF and suggests a novel approach on how to take into account the varying heart cycle lengths in AF. METHODS: Echocardiograms from 204 patients with AF during examination were analyzed offline. Patients with known heart failure (HF) were excluded. Peak global longitudinal strain (GLS) was averaged from 18 myocardial segments...
July 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29751954/novel-echocardiographic-parameters-in-patients-with-aortic-stenosis-and-preserved-left-ventricular-systolic-function-undergoing-surgical-aortic-valve-replacement
#4
Chetan P Huded, Kenya Kusunose, Fatima Shahid, Andrew L Goodman, Alaa Alashi, Richard A Grimm, A Marc Gillinov, Douglas R Johnston, L Leonardo Rodriguez, Zoran B Popovic, Kimi Sato, Lars G Svensson, Brian P Griffin, Milind Y Desai
We sought to study the incremental prognostic impact of baseline valvuloarterial impedance (Zva) and left ventricular global longitudinal strain (LV-GLS) in patients with severe aortic stenosis and preserved left ventricular ejection fraction (LVEF) treated with surgical aortic valve replacement (AVR). We included 961 consecutive patients (68 ± 13 years; 63% men) with severe aortic stenosis (indexed aortic valve area <0.6 cm2 ) and LVEF >50% who underwent surgical AVR at our institution between January 2007 and December 2008...
April 12, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29748699/longitudinal-deformation-of-the-right-ventricle-in-hypoplastic-left-heart-syndrome-a-comparative-study-of-2d-feature-tracking-magnetic-resonance-imaging-and-2d-speckle-tracking-echocardiography
#5
Mona Salehi Ravesh, Carsten Rickers, Finn Jonathan Bannert, David Hautemann, Abdullah Al Bulushi, Dominik Daniel Gabbert, Philip Wegner, Eva Kis, Jan Hinnerk Hansen, Michaeal Jerosch-Herold, H-H Kramer, Jana Logoteta
In hypoplastic left heart syndrome (HLHS), long-term outcome is closely related to right ventricular function. Echocardiography and magnetic resonance imaging (MRI) are routinely used for functional assessment. MRI 2D-tissue feature tracking (2D-FT) allows quantification of myocardial deformation but has not yet been applied to HLHS patients. We sought to investigate the feasibility of this technique and to compare the results to 2D-speckle tracking echocardiography (2D-STE). In routine MRI 2D anatomical four chamber view, cine images were recorded in 55 HLHS patients (median age 4...
May 10, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29746112/genotypic-variation-of-glucosinolates-and-their-breakdown-products-in-leaves-of-brassica-rapa
#6
Rebecca Klopsch, Katja Witzel, Anna Artemyeva, Silke Ruppel, F Hanschen
An in-depth glucosinolate (GLS) profiling was performed on a core collection of 91 Brassica rapa accessions, representing divers morphotypes of heterogenous geographical origin, to better understand the natural variation in GLS accumulation and GLS breakdown product formation. Leaves of the 91 B. rapa accessions were analyzed for their GLS composition by UHPLC-DAD and the corresponding breakdown products by GC-MS. Fifteen different GLS were identified and aliphatic GLS prevailed regarding diversity and concentration...
May 10, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29741807/genetically-determined-pattern-of-left-ventricular-function-in-normal-and-hypertensive-hearts
#7
Attila Kovács, Andrea Ágnes Molnár, Márton Kolossváry, Bálint Szilveszter, Alexisz Panajotu, Bálint Károly Lakatos, Levente Littvay, Ádám Domonkos Tárnoki, Dávid László Tárnoki, Szilard Voros, György Jermendy, Partho P Sengupta, Béla Merkely, Pál Maurovich-Horvat
We sought to assess the inheritance of left ventricular (LV) function using speckle-tracking echocardiography and the impact of hypertension on modifying the genetically determined pattern of contraction in a population of twins. We recruited 92 Caucasian twin pairs, including 74 hypertensive (HTN) siblings. Beyond standard echocardiographic protocol, a speckle-tracking analysis was performed, including global longitudinal strain (GLS). Systolic function, as assessed by ejection fraction, showed moderate heritability (61%); however, GLS showed higher and dominant heritability (75%)...
May 9, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29738500/protective-effect-of-glucosinolates-hydrolytic-products-in-neurodegenerative-diseases-ndds
#8
REVIEW
Mohammed Sani Jaafaru, Nurul Ashikin Abd Karim, Mohamad Eliaser Enas, Patrick Rollin, Emanuela Mazzon, Ahmad Faizal Abdull Razis
Crucifer vegetables, Brassicaceae and other species of the order Brassicales, e.g., Moringaceae that are commonly consumed as spice and food, have been reported to have potential benefits for the treatment and prevention of several health disorders. Though epidemiologically inconclusive, investigations have shown that consumption of those vegetables may result in reducing and preventing the risks associated with neurodegenerative disease development and may also exert other biological protections in humans...
May 8, 2018: Nutrients
https://www.readbyqxmd.com/read/29737531/specific-expression-network-analysis-of-diabetic-nephropathy-kidney-tissue-revealed-key-methylated-sites
#9
Yan-Zhe Wang, Wen-Wei Xu, Ding-Yu Zhu, Nan Zhang, Yong-Lan Wang, Miao Ding, Xin-Miao Xie, Lin-Lin Sun, Xiao-Xia Wang
Diabetic nephropathy (DN) is one of the most common and serious complication in diabetes patients. However, the evidences of gene regulation mechanism and epigenetic modification with DN remain unclear. Therefore, it is necessary to search regulating genes for early diagnosis on DN. We identified tissue specific genes through mining the gene expression omnibus (GEO) public database, enriched function by gene ontology (GO), and kyoto encyclopedia of genes and genomes (KEGG) analysis, and further compared tissue-specific network...
May 8, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29731506/future-perspectives-for-management-of-stage-a-heart-failure
#10
Hidekazu Tanaka
Patients with Stage A heart failure (HF) show no HF symptoms but have related comorbid diseases with a high risk of progressing to HF. Screening for comorbid diseases warrants closer attention because of the growing interest in addressing Stage A HF as the best means of preventing eventual progression to overt HF such as Stages C and D. The identification of individuals of Stage A HF is potentially useful for the implementation of HF-prevention strategies; however, not all Stage A HF patients develop left ventricular (LV) structural heart disease or symptomatic HF, which lead to advanced HF stages...
May 7, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29730688/the-value-of-global-longitudinal-strain-and-galectin-3-for-predicting-cardiovascular-events-in-patients-with-severe-aortic-stenosis
#11
Lucia Agoston-Coldea, Kunal Bheecarry, Cristian Petra, Lelia Strambu, Camelia Ober, Radu Revnic, Silvia Lupu, Teodora Mocan, Daniela Fodor
AIMS: Left ventricular global longitudinal strain (GLS) was shown to predict outcomes after valve replacement in patients with aortic stenosis (AS). In the current study, we aimed to test the combined use of GLS and a marker of fibrosis - Galectin-3 - for predicting major cardiovascular adverse events (MACEs) in patients with severe AS. MATERIALS AND METHODS: We conducted a prospective study on 42 patients with severe AS and 42 volunteers. Patient evaluation included biochemistry tests, electrocardiogram, 24-hour Holter monitoring, the 6-minute walk test, and echocardiography...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29728952/myocardial-perfusion-reserve-and-global-longitudinal-strain-as-potential-markers-of-coronary-allograft-vasculopathy-in-late-stage-orthotopic-heart-transplantation
#12
Akhil Narang, John E Blair, Mita B Patel, Victor Mor-Avi, Savitri E Fedson, Nir Uriel, Roberto M Lang, Amit R Patel
Coronary allograft vasculopathy (CAV) is a major cause of mortality in late-stage orthotopic heart transplantation (OHT) patients. Recent evidence has shown that myocardial perfusion reserve (MPR) derived from vasodilator cardiovascular magnetic resonance imaging (vCMR) and global longitudinal strain (GLS) from transthoracic echocardiography (TTE) are useful to detect CAV. However, previous studies have not comprehensively addressed whether these parameters are confounded by allograft rejection, myocardial scar/fibrosis, or allograft dysfunction...
May 4, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29724796/gad65-promoter-polymorphism-rs2236418-modulates-harm-avoidance-in-women-via-inhibition-excitation-balance-in-the-rostral-acc
#13
Lejla Colic, Meng Li, Liliana Ramona Demenescu, Shija Li, Iris Müller, Anni Richter, Constanze I Seidenbecher, Oliver Speck, Björn H Schott, Oliver Stork, Martin Walter
Anxiety disorders are common and debilitating conditions with higher prevalence in women. However, factors that predispose women to anxiety phenotypes are not clarified. Here we investigated potential contribution of the single nucleotide polymorphism rs2236418 in GAD2 gene to changes in regional inhibition/excitation balance, anxiety-like traits and related neural activity in both sexes. 105 healthy individuals were examined with high-field (7T) multimodal magnetic resonance imaging (MRI), including resting state fMRI in combination with assessment of GABA and Glutamate (Glu) levels via MR spectroscopy (MRS)...
May 3, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29724346/global-longitudinal-strain-to-predict-mortality-in-patients-with-acute-heart-failure
#14
Jin Joo Park, Jun-Bean Park, Jae-Hyeong Park, Goo-Yeong Cho
BACKGROUND: Heart failure (HF) is currently classified according to left ventricular ejection fraction (LVEF); however, the prognostic value of LVEF is controversial. Myocardial strain is a prognostic factor independently of LVEF. OBJECTIVES: The authors sought to evaluate the prognostic value of global longitudinal strain (GLS) in patients with HF. METHODS: GLS was measured in 4,172 consecutive patients with acute HF. Patients were categorized as either HF with reduced (LVEF <40%), midrange (LVEF 40% to 49%), or preserved ejection fraction (LVEF ≥50%) and were also classified as having mildly (GLS >12...
May 8, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29709303/assessment-of-longitudinal-systolic-function-using-tissue-motion-annular-displacement-in-healthy-dogs
#15
Marcela Wolf, Stephany B Lucina, Bruna C Brüler, Giovana L R Tuleski, Vinícius B C Silva, Marlos G Sousa
INTRODUCTION: Left ventricular systolic function is one of the main parameters studied in echocardiography. Longitudinal systolic function, however, is less commonly evaluated in routine examinations but may provide early information on systolic dysfunction. The movement of the mitral annulus toward the apex has already been determined as a method for evaluation of longitudinal systolic function in dogs, but the study of this movement by speckle tracking with the tissue motion annular displacement (TMAD) technique has not yet been evaluated...
April 27, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29694546/subclinical-anthracycline-induced-cardiotoxicity-in-the-long-term-follow-up-of-lymphoma-survivors-a-multi-layer-speckle-tracking-analysis
#16
Yu Kang, Fei Xiao, Haiyan Chen, Wei Wang, Lijing Shen, Hang Zhao, Xuedong Shen, Fangyuan Chen, Ben He
BACKGROUND: Anthracycline generates progressive left ventricular dysfunction associated with a poor prognosis. OBJECTIVES: The purpose of this study was to evaluate whether layer-specific strain analysis could assess the subclinical left ventricular dysfunction after exposure to anthracycline. METHODS: Forty-two anthracycline-treated survivors of large B-cell non-Hodgkin lymphoma, aged 55.83 ± 17.92 years (chemotherapy group) and 27 healthy volunteers, aged 51...
March 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29694432/enhanced-production-of-polysaccharides-and-triterpenoids-in-ganoderma-lucidum-fruit-bodies-on-induction-with-signal-transduction-during-the-fruiting-stage
#17
Liyun Ye, Shengrong Liu, Fan Xie, Lili Zhao, Xiaoping Wu
Ganoderma lucidum is a medicinal mushroom that has been widely used in East Asia for the treatment of various diseases. The pharmacological activity of this fungus is primarily attributable to the polysaccharides and triterpenoids. In this study, to obtain the fruit bodies with improved content of active constituents, we examined the effect of salicylic acid (SA) and calcium ion on the biosynthesis of polysaccharides and triterpenoids by spraying the chemicals during the fruiting. To explore the underlying mechanisms for the variation, the transcripts of related genes involved in the polysaccharide and triterpenoid biosynthesis were measured...
2018: PloS One
https://www.readbyqxmd.com/read/29694350/predicting-seasonal-influenza-transmission-using-functional-regression-models-with-temporal-dependence
#18
Manuel Oviedo de la Fuente, Manuel Febrero-Bande, María Pilar Muñoz, Àngela Domínguez
This paper proposes a novel approach that uses meteorological information to predict the incidence of influenza in Galicia (Spain). It extends the Generalized Least Squares (GLS) methods in the multivariate framework to functional regression models with dependent errors. These kinds of models are useful when the recent history of the incidence of influenza are readily unavailable (for instance, by delays on the communication with health informants) and the prediction must be constructed by correcting the temporal dependence of the residuals and using more accessible variables...
2018: PloS One
https://www.readbyqxmd.com/read/29691224/echo-and-heart-failure-when-do-people-need-an-echo-and-when-do-they-need-natriuretic-peptides
#19
REVIEW
Daniel Modin, Ditte Madsen Andersen, Tor Biering-Sørensen
Heart failure (HF) is a threat to public health. Heterogeneities in etiology and phenotype complicate the diagnosis and management of HF. This is especially true when considering HF with preserved ejection fraction (HFpEF) which make up 50% of HF cases. Natriuretic peptides may aid in establishing a working diagnosis in patients suspected of HF, but echocardiography remains the optimal choice for diagnosing HF. Echocardiography provides important prognostic information in both HF with reduced ejection fraction (HFrEF) and HFpEF...
April 24, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29681243/association-between-myocardial-extracellular-volume-and-strain-analysis-through-cardiovascular-magnetic-resonance-with-histological-myocardial-fibrosis-in-patients-awaiting-heart-transplantation
#20
Yue Cui, Yukun Cao, Jing Song, Nianguo Dong, Xiangchuang Kong, Jing Wang, Yating Yuan, Xiaolei Zhu, Xu Yan, Andreas Greiser, Heshui Shi, Ping Han
BACKGROUND: Cardiovascular magnetic resonance (CMR)-derived extracellular volume (ECV) and tissue tracking strain analyses are proposed as non-invasive methods for quantifying myocardial fibrosis and deformation. This study sought (1) to histologically validate myocardial ECV against the collagen volume fraction (CVF) measured from tissue samples of patients undergoing heart transplantation and (2) to detect the correlations between myocardial systolic strain and the myocardial ECV and histological CVF in patients undergoing heart transplantation...
April 23, 2018: Journal of Cardiovascular Magnetic Resonance
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