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https://www.readbyqxmd.com/read/28430666/myc-induced-glutaminolysis-bypasses-hif-driven-glycolysis-in-hypoxic-small-cell-lung-carcinoma-cells
#1
Matilda Munksgaard Thorén, Marica Vaapil, Johan Staaf, Maria Planck, Martin E Johansson, Sofie Mohlin, Sven Påhlman
We previously demonstrated that small cell lung carcinoma (SCLC) cells lack HIF-2α protein expression, whereas HIF-1α in these cells is expressed at both acute and prolonged hypoxia. Here we show that low HIF2A expression correlates with high expression of MYC genes. Knockdown of HIF1A expression had no or limited effect on cell survival and growth in vitro. Unexpectedly, hypoxic ATP levels were not affected by HIF-1α knockdown and SCLC cell viability did not decrease upon glucose deprivation. In line with these in vitro data, xenograft tumor-take and growth were not significantly affected by repressed HIF1A expression...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426885/prognostic-implications-of-left-ventricular-global-longitudinal-strain-in-heart-failure-patients-with-narrow-qrs-complex-treated-with-cardiac-resynchronization-therapy-a-subanalysis-of-the-randomized-echocrt-trial
#2
Jeroen J Bax, Victoria Delgado, Peter Sogaard, Jagmeet P Singh, William T Abraham, Jeffrey S Borer, Kenneth Dickstein, Daniel Gras, Josep Brugada, Michele Robertson, Ian Ford, Henry Krum, Johannes Holzmeister, Frank Ruschitzka, John Gorcsan
Aim: Left ventricular (LV) global longitudinal strain (GLS) reflects LV systolic function and correlates inversely with the extent of LV myocardial scar and fibrosis. The present subanalysis of the Echocardiography Guided CRT trial investigated the prognostic value of LV GLS in patients with narrow QRS complex. Methods and results: Left ventricular (LV) global longitudinal strain (GLS) was measured on the apical 2-, 4- and 3-chamber views using speckle tracking analysis...
March 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28423986/global-longitudinal-strain-from-resting-echocardiogram-is-associated-with-long-term-adverse-cardiac-outcomes-in-patients-with-suspected-coronary-artery-disease
#3
Ajay Yadlapati, Timothy R Maher, James D Thomas, Mark Gajjar, Kofo O Ogunyankin, Jyothy J Puthumana
PURPOSE: Measuring myocardial strain using two-dimensional speckle tracking echocardiography has emerged as a new tool to identify subclinical ventricular dysfunction. Abnormal strain has been shown to have superior sensitivity compared with dobutamine stress echocardiography for viability assessment; however, there is a paucity of data regarding the prediction of long-term major adverse cardiac events. We compared the prognostic ability of both global longitudinal strain (GLS) from resting echocardiograms to regional wall motion score index (WMSI) from stress echocardiograms in their ability to predict long-term major adverse cardiac events...
March 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28421305/the-utility-of-global-longitudinal-strain-in-the-identification-of-prior-myocardial-infarction-in-patients-with-preserved-left-ventricular-ejection-fraction
#4
Graham J Fent, Pankaj Garg, James R J Foley, Laura E Dobson, Tarique A Musa, Bara Erhayiem, John P Greenwood, Sven Plein, Peter P Swoboda
Prior myocardial infarction (MI) is associated with increased mortality and is prevalent in certain high risk patient groups. Electrocardiogram may be used in diagnosis, however, sensitivity is limited, thus non-invasive imaging techniques may improve diagnosis. We investigated whether global longitudinal strain (GLS) and longitudinal strain parameters are reduced in patients with prior MI but preserved left ventricular ejection fraction (LVEF). The study included 40 clinical patients with prior MI occurring >3 months previously (defined as subendocardial hyperenhancement on late Gadolinium enhancement imaging) with LVEF ≥ 55% and 40 controls matched for age and LVEF...
April 18, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28419960/preferentially-enhancing-anti-cancer-isothiocyanates-over-glucosinolates-in-broccoli-sprouts-how-nacl-and-salicylic-acid-affect-their-formation
#5
Azadeh Esfandiari, Ali Saei, Marian J McKenzie, Adam J Matich, Mesbah Babalar, Donald A Hunter
Broccoli (Brassica oleracea L. var. italica) sprouts contain glucosinolates (GLs) that when hydrolysed yield health promoting isothiocyanates such as sulforaphane (SF). SF content can be increased by salt (NaCl) stress, although high salt concentrations negatively impact plant growth. Salicylic acid (SA) treatments can attenuate the negative effects of salt on growth. To test whether sprout isothiocyanate content could be elevated without sprout growth being compromised, broccoli seed were germinated and grown for seven days in salt (0, 80 and 160 mM) alone and in combination with 100 μM SA...
April 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28415128/p1270effects-of-blood-pressure-variability-on-layer-specific-longitudinal-strain-in-hypertension
#6
W-C Tsai, W-H Lee, Y-W Liu
Background: Our previous study showed sub-epicardial longitudinal strain (EpiLS) was an independent prognostic factor for worse outcome in regular treated hypertension but not global longitudinal strain (GLS) and sub-endocardial longitudinal strain (EndLS). Increased blood pressure variability (BPV) has been found associated with target organ damage in hypertension. However, effects of BPV on layer-specific longitudinal strain have not been well studied. Purpose: The aim of this study was to investigate the effects of different blood pressure parameters on layer-specific longitudinal strain in hypertension...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28415103/p673improvement-of-arterial-stiffness-and-myocardial-deformation-in-patients-with-poorly-controlled-diabetes-mellitus-type-2-after-optimization-of-antidiabetic-medication
#7
I Ikonomidis, G Pavlidis, V Lambadiari, F Kousathana, H Triantafyllidi, M Varoudi, D Vlastos, S Vlachos, G Dimitriadis, J Lekakis
Background: Arterial stiffness is associated with increased risk for cardiovascular disease. The purpose of this study is to investigate the arterial stiffness and myocardial deformation in patients with poorly controlled diabetes mellitus type 2 before and after glycemic control by optimal medication. Methods: In 50 patients with uncontrolled type 2 diabetes(age:52±10years)and 25 controls of similar age and sex and no atherosclerotic risk factors we measured at baseline and 6 months after glycemic control a) carotid-femoral pulse wave velocity(PWVc m/sec-Complior SP ALAM),central systolic blood pressure(cSBP -mmHg),augmentation index(AI%), of the aortic pulse wave(ArteriographTensioMed) b)S',E'(m/sec)andE'/A'of mitral annulus by Tissue Doppler c)LV longitudinal strain(GLS-%),systolic(LongSr-l/sec)and diastolic(LongSrE-l/sec)strain rate, twisting(Tw-deg),peak twisting(Tw)and untwisting(unTw-deg/sec)velocity using speckle tracking echocardiography...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28415084/p260right-cardiac-chambers-remodeling-in-marathon-and-ultra-trail-athletes-detected-by-speckle-tracking-echocardiography
#8
K Ujka, R M Bruno, B Catuzzo, L Bastiani, A Tonacci, G D'angelo, S Mrakic-Sposta, A Vezzoli, G Giardini, L Pratali
Background: Strenuous and chronic exercise training can have detrimental effects on cardiac morphology and function. Our aim was to evaluate the cardiac adaptation between 2 different specialties' endurance athletes: marathon runners (M) and ultra-trailers (UT). Methods: 47 M (age 45±7, men 32; training: 18 (9-53) years*days/week), 41 UT (age 42±9, men 38, training: 30 (15-66) years*days/week) were submitted in rest condition to conventional 2D echocardiography and Speckle-Tracking echo (STE) (Beyond Diogenes 2...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28407011/anthracyclines-induce-early-changes-in-left-ventricular-systolic-and-diastolic-function-a-single-centre-study
#9
Anita Boyd, Paul Stoodley, David Richards, Rina Hui, Paul Harnett, Kim Vo, Tom Marwick, Liza Thomas
AIMS: 2 dimensional (2D) strain analysis detects subclinical left ventricular (LV) systolic dysfunction. Our aim was to evaluate changes in LV systolic and diastolic function in breast cancer patients early after anthracycline chemotherapy, and to identify predisposing factors. METHODS AND RESULTS: 140 patients were assessed by detailed echocardiography before and within seven days post treatment. LV ejection fraction (LVEF), global longitudinal strain (GLS), strain rate and radial and circumferential strain were assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28399896/glutaminase-1-plays-a-key-role-in-the-cell-growth-of-fibroblast-like-synoviocytes-in-rheumatoid-arthritis
#10
Soshi Takahashi, Jun Saegusa, Sho Sendo, Takaichi Okano, Kengo Akashi, Yasuhiro Irino, Akio Morinobu
BACKGROUND: The recent findings of cancer-specific metabolic changes, including increased glucose and glutamine consumption, have provided new therapeutic targets for consideration. Fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients exhibit several tumor cell-like characteristics; however, the role of glucose and glutamine metabolism in the aberrant proliferation of these cells is unclear. Here, we evaluated the role of these metabolic pathways in RA-FLS proliferation and in autoimmune arthritis in SKG mice...
April 11, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28399703/value-of-speckle-tracking-echocardiography-for-detection-of-clinically-silent-left-ventricular-dysfunction-in-patients-with-%C3%AE-thalassemia
#11
Mozhgan Parsaee, Sedigheh Saedi, Pegah Joghataei, Azita Azarkeivan, Zahra Alizadeh Sani
OBJECTIVE: β-Thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia requiring chronic transfusion therapy. Cardiac involvement is the main cause of death in patients with thalassemia major. The narrow border is between overt myocardial dysfunction and clinically silent left ventricular (LV) dysfunction in patients with thalassemia. Therefore, we need novel parameters in different imaging techniques to discover cardiac involvement in an early and subtle stage...
April 12, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28391000/prognostic-role-of-subclinical-left-ventricular-systolic-dysfunction-evaluated-by-speckle-tracking-echocardiography-in-rheumatoid-arthritis
#12
Giovanni Cioffi, Ombretta Viapiana, Federica Ognibeni, Andrea Dalbeni, Alessandro Giollo, Davide Gatti, Luca Idolazzi, Giorgio Faganello, Andrea Di Lenarda, Maurizio Rossini
BACKGROUND: Speckle-tracking echocardiography allows early detection of subclinical left ventricular systolic dysfunction (LVSD) in patients with rheumatoid arthritis (RA). In this prospective study, we assessed the prevalence and the prognostic role of subclinical LVSD detected by speckle-tracking echocardiography in RA patients. METHODS: Two-dimensional global longitudinal strain (GLS) and global circumferential strain (GCS) were measured in 209 RA patients without overt cardiac disease...
April 6, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28390683/prognostic-utility-of-right-ventricular-free-wall-strain-in-low-risk-patients-after-orthotopic-heart-transplantation
#13
Amr F Barakat, Brett W Sperry, Randall C Starling, Amgad Mentias, Zoran B Popovic, Brian P Griffin, Milind Y Desai
Global longitudinal strain (GLS) by speckle-tracking echocardiography is a sensitive measure of regional left and right ventricular (LV and RV) dysfunction, before onset of overt systolic dysfunction. We sought to evaluate the prognostic utility of measuring LV-GLS and RV free wall strain (FWS) in low risk patients at 1 year after orthotopic heart transplantation (OHT). We retrospectively studied 96 OHT recipients (age 52 ± 14 years, 64% men) free of antibody-mediated rejection or moderate to severe coronary allograft vasculopathy (CAV, grade 2 to 3) at 1 year after transplant...
March 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28385047/breaking-the-sporoderm-of-ganoderma-lucidum-spores-by-combining-chemical-reaction-with-physical-actuation
#14
Jiajia Wang, Rui Ke, Shengyi Zhang
The hard and indissolvable sporoderm of Ganoderma lucidum spore (GLS) hinders the release of bioactive components that are significant to disease treatment and vitality enhancement. In this paper, a strategy to break sporoderm was proposed, in which the chemical reaction was cooperated with physical actuation (ultrasonication and refrigeration). Dealing with this chemicophysical treatment, the porous sporoderm of GLS was formed, which was confirmed by scanning electron microscope (SEM). The effect factors and mechanism of breaking sporoderm were discussed, and the efficiency of breaking sporoderm was evaluated by detecting the dissolution behaviour of inner triterpenoids in GLS...
April 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28380951/near-infrared-spectro-interferometer-using-femtosecond-laser-written-gls-embedded-waveguides-and-nano-scatterers
#15
G Martin, M Bhuyan, J Troles, C D'Amico, R Stoian, E Le Coarer
Guided optics spectrometers can be essentially classified into two main families: based on Fourier transform or dispersion. In the first case, an interferogram generated inside an optical waveguide and containing the spectral information is sampled using spatially distributed nanodetectors. These scatter quasi-non-perturbingly light into the detector that is in contact with the waveguide, helping to reconstruct the stationary wave. A dedicated FFT processing is needed in order to recover the spectrum with high resolution but limited spectral range...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28380812/nonlinear-response-of-infrared-photodetectors-based-on-van-der-waals-heterostructures-with-graphene-layers
#16
Victor Ryzhii, Maxim Ryzhii, Dmitry Svintsov, Vladimir Leiman, Vladimir Mitin, Michael S Shur, Taiichi Otsuji
We report on the device model for the infrared photodetectors based on the van der Waals (vdW) heterostructures with the radiation absorbing graphene layers (GLs). These devices rely on the electron interband photoexcitation from the valence band of the GLs to the continuum states in the conduction band of the inter-GL barrier layers. We calculate the photocurrent and the GL infrared photodetector (GLIP) responsivity at weak and strong intensities of the incident radiation and conclude that the GLIPs can surpass or compete with the existing infrared and terahertz photodetectors...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28379383/2d-and-3d-strain-for-detection-of-subclinical-anthracycline-cardiotoxicity-in-breast-cancer-patients-a-balance-with-feasibility
#17
Ciro Santoro, Grazia Arpino, Roberta Esposito, Maria Lembo, Immacolata Paciolla, Cinzia Cardalesi, Giovanni de Simone, Bruno Trimarco, Sabino De Placido, Maurizio Galderisi
Aims: 2D echocardiography is limited for identifying chemotherapy-related cardiotoxicity. This study compared standard echo, 2D, and 3D speckle tracking echocardiography (STE) for detection of subclinical anthracycline (ANT) cardiotoxicity in breast cancer patients. Methods and results: One-hundred consecutive breast cancer patients free of cardiac symptoms were treated by multiple protocols including ANT and cyclophosphamide and/or 5-fluorouracil for 3-4 cycles...
March 31, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28372865/left-ventricular-morphology-and-function-in-adolescents-relations-to-fitness-and-fatness
#18
Katrin A Dias, Angela L Spence, Satyam Sarma, David Oxborough, Anita S Timilsina, Peter S W Davies, Peter A Cain, Gary M Leong, Charlotte B Ingul, Jeff S Coombes
BACKGROUND: Obesity in childhood predisposes individuals to cardiovascular disease and increased risk of premature all-cause mortality. The aim of this study was to determine differences in LV morphology and function in obese and normal-weight adolescents. Furthermore, relationships between LV outcomes, cardiorespiratory fitness (CRF) and adiposity were explored. METHODS: LV morphology was assessed using magnetic resonance imaging (MRI) in 20 adolescents (11 normal-weight [BMI equivalent to 18kg/m(2)-25kg/m(2)] and 9 obese [BMI equivalent to ≥30kg/m(2)]); 13...
March 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28367380/the-adaptive-value-of-habitat-preferences-from-a-multi-scale-spatial-perspective-insights-from-marsh-nesting-avian-species
#19
Jan Jedlikowski, Mattia Brambilla
BACKGROUND: Habitat selection and its adaptive outcomes are crucial features for animal life-history strategies. Nevertheless, congruence between habitat preferences and breeding success has been rarely demonstrated, which may result from the single-scale evaluation of animal choices. As habitat selection is a complex multi-scale process in many groups of animal species, investigating adaptiveness of habitat selection in a multi-scale framework is crucial. In this study, we explore whether habitat preferences acting at different spatial scales enhance the fitness of bird species, and check the appropriateness of single vs...
2017: PeerJ
https://www.readbyqxmd.com/read/28365571/subclinical-cardiac-dysfunction-in-polymyositis-and-dermatomyositis-a-speckle-tracking-case-control-study
#20
Federico Guerra, Chiara Gelardi, Alessandro Capucci, Armando Gabrielli, Maria Giovanna Danieli
OBJECTIVE: Subclinical heart disease occurs in up to 50% of patients with idiopathic inflammatory myopathies (IIM) and is difficult to detect through conventional imaging. We investigated the usefulness of global longitudinal strain (GLS) measurement to detect a subclinical systolic ventricular dysfunction in patients with IIM. METHODS: We enrolled 28 patients with IIM and 28 matched controls in a 1:1 fashion. Standard variables for the left ventricle (LV) and right ventricle (RV) systolic and diastolic function were measured and compared between cases and controls, along with speckle-tracking GLS of the LV and RV...
April 1, 2017: Journal of Rheumatology
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