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https://www.readbyqxmd.com/read/28087972/lack-of-effect-of-oral-cabotegravir-on-the-pharmacokinetics-of-a-levonorgestrel-ethinyl-estradiol-containing-oral-contraceptive-in-healthy-adult-females
#1
C Trezza, S L Ford, E Gould, Y Lou, C Huang, J M Ritter, A M Buchanan, W Spreen, P Patel
AIM(S): This study aimed to investigate whether cabotegravir (CAB), an integrase inhibitor in development for treatment and prevention of HIV-1, influences the pharmacokinetics (PK) of a levonorgestrel (LNG) and ethinyl estradiol (EE)-containing oral contraceptive (OC) in healthy women. METHODS: In this open-label, fixed-sequence crossover study, healthy female subjects received LNG 0.15 mg/EE 0.03 mg tablet once daily Days 1-10 alone and with oral CAB 30 mg once daily Days 11-21...
January 14, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28072551/assessment-of-subclinical-left-ventricular-changes-in-essential-hypertensive-patients-with-hyperuricemia-a-three-dimensional-speckle-tracking-echocardiography-study
#2
Xiaoyan Fang, Cuizhen Pan, Yongle Chen, Minmin Sun, Zhuojun Zhang, Lindi Jiang, Xiaolin Wang, Xianhong Shu
OBJECTIVE: To evaluate the effect of hyperuricemia (HU) on subclinical changes of left ventricle (LV) function and structure in patients with hypertension (HT) using three-dimensional speckle-tracking echocardiography (3DSTE) and to explore the relationships between serum uric acid (SUA) levels and three-dimensional speckle tracking echocardiography (3DSTE) parameters in hypertensive and nonhypertensive patients with HU. METHODS: Four age- and sex-matched groups were studied: I: healthy controls, HT- HU- (n = 40); II: HT- HU+ (n = 40); III: HT+ HU- (n = 40); IV: HT+ HU+ (n = 44)...
January 10, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28070903/myocardial-deformation-in-pediatric-patients-with-mucopolysaccharidoses-a-two-dimensional-speckle-tracking-echocardiography-study
#3
Francesco Borgia, Enrica Pezzullo, Vincenzo Schiano Lomoriello, Regina Sorrentino, Francesco Lo Iudice, Sara Cocozza, Roberto Della Casa, Giancarlo Parenti, Pietro Strisciuglio, Bruno Trimarco, Maurizio Galderisi
BACKGROUND: Mucopolysaccharidoses (MPS) are inherited lysosomal storage disorders caused by deficiency of required glycosaminoglycans breakdown enzymes, inducing cardiac involvement. Little is known about myocardial deformation involvement in MPS. Our aim was to assess biventricular structure and function in asymptomatic children with MPS using standard echo Doppler and 2D speckle tracking (STE). METHODS: Fifteen MPS children (one type I, six type II, three type III A, one III B, three IV A, one VI), asymptomatic for cardiac symptoms, and 15 age and sex-matched healthy controls underwent echo Doppler and STE...
January 10, 2017: Echocardiography
https://www.readbyqxmd.com/read/28069573/relations-between-aortic-stiffness-and-left-ventricular-mechanical-function-in-the-community
#4
Vanessa Bell, Elizabeth L McCabe, Martin G Larson, Jian Rong, Allison A Merz, Ewa Osypiuk, Birgitta T Lehman, Plamen Stantchev, Jayashri Aragam, Emelia J Benjamin, Naomi M Hamburg, Ramachandran S Vasan, Gary F Mitchell, Susan Cheng
BACKGROUND: Aortic stiffness impairs optimal ventricular-vascular coupling and left ventricular systolic function, particularly in the long axis. Left ventricular global longitudinal strain (GLS) has recently emerged as a sensitive measure of early cardiac dysfunction. In this study, we investigated the relation between aortic stiffness and GLS in a large community-based sample. METHODS AND RESULTS: In 2495 participants (age 39-90 years, 57% women) of the Framingham Offspring and Omni cohorts, free of cardiovascular disease, we performed tonometry to measure arterial hemodynamics and echocardiography to assess cardiac function...
January 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28065584/mechanical-dispersion-by-strain-echocardiography-a-novel-tool-to-diagnose-hypertrophic-cardiomyopathy-in-athletes
#5
Frédéric Schnell, David Matelot, Magalie Daudin, Gaelle Kervio, Philippe Mabo, François Carré, Erwan Donal
BACKGROUND: Previous studies have demonstrated that global longitudinal strain (GLS) is altered in patients with hypertrophic cardiomyopathy (HCM) in comparison with athletes. Nevertheless, these results rely on studies comparing sedentary patients with HCM with healthy athletes. The aims of this study were to confirm these findings in an appropriate group of athletes with HCM and to study the additive value of novel parameters (i.e., mechanical dispersion and exercise GLS). METHODS: Thirty-six athletes with HCM were prospectively included and were compared with 36 sedentary patients with HCM, 36 healthy athletes, and 36 sedentary control subjects of similar age...
January 5, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28065583/left-ventricular-contraction-pattern-in-chronic-aortic-regurgitation-and-preserved-ejection-fraction-simultaneous-stress-strain-analysis-by-three-dimensional-echocardiography
#6
Kaspar Broch, Stefano F de Marchi, Richard Massey, Jonny Hisdal, Svend Aakhus, Lars Gullestad, Stig Urheim
BACKGROUND: The role of speckle-tracking echocardiography in the assessment of chronic aortic regurgitation (AR) is not established. Load dependency may encumber the interpretation of strain measurements in the chronically overloaded left ventricle. The aim of this study was to investigate the mechanisms of left ventricular (LV) contraction patterns in asymptomatic patients with moderate to severe AR and preserved ejection fractions. METHODS: In this prospective, cross-sectional study, 31 patients with moderate to severe AR, 15 elite endurance athletes, and 17 healthy control subjects were examined using three-dimensional speckle-tracking echocardiography...
January 5, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28065448/left-ventricular-dyssynchrony-and-2d-and-3d-global-longitudinal-strain-for-differentiating-physiological-and-pathological-left-ventricular-hypertrophy
#7
Julien Ternacle, Camille Bremont, Thomas d'Humieres, Laureline Faivre, Huy Long Doan, Romain Gallet, Leopold Oliver, Jean-Luc Dubois-Randé, Pascal Lim
BACKGROUND: Diagnosis of hypertrophic cardiomyopathy (HCM) in athletes can be challenging. AIMS: To ascertain parameters that differentiate patients with HCM from athletes with moderate left ventricular (LV) hypertrophy (LVH 13-15mm). METHODS: We retrospectively included 100 men: 50 elite rugby players (25 with moderate LVH and 25 with no LVH), 25 patients with HCM and moderate LVH and 25 controls. LV dyssynchrony was defined as the standard deviation of time to peak 2D longitudinal strain (16-segment model) and global strain components were computed from two- (2D) and three-dimensional (3D) speckle tracking...
January 3, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28064155/assessment-of-global-longitudinal-strain-at-low-dose-anthracycline-based-chemotherapy-for-the-prediction-of-subsequent-cardiotoxicity
#8
Clément Charbonnel, Raphaele Convers-Domart, Sophie Rigaudeau, Anne Laure Taksin, Nicolas Baron, Juliette Lambert, Stéphanie Ghez, Jean-Louis Georges, Hassan Farhat, Jérôme Lambert, Philippe Rousselot, Bernard Livarek
AIMS: We sought to assess whether global longitudinal strain (GLS) measured early during treatment with anthracyclines (at a cumulative dose of 150 mg/m(2)) can predict subsequent alterations in left ventricular ejection fraction. METHODS AND RESULTS: Eighty-six patients with Hodgkin's disease, non-Hodgkin's lymphoma, or acute leukaemia and receiving anthracyclines were prospectively included. Patients underwent complete echocardiography on four occasions: baseline (V1); after reaching a cumulative dose of 150 mg/m(2) (V2); end of treatment (V3); and 1 year follow-up (V4)...
January 6, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28056808/comparison-of-global-myocardial-strain-assessed-by-cardiovascular-magnetic-resonance-tagging-and-feature-tracking-to-infarct-size-at-predicting-remodelling-following-stemi
#9
Abhishek M Shetye, Sheraz A Nazir, Naveed A Razvi, Nathan Price, Jamal N Khan, Florence Y Lai, Iain B Squire, Gerald P McCann, Jayanth R Arnold
BACKGROUND: To determine if global strain parameters measured by cardiovascular magnetic resonance (CMR) acutely following ST-segment Elevation Myocardial Infarction (STEMI) predict adverse left ventricular (LV) remodelling independent of infarct size (IS). METHODS: Sixty-five patients with acute STEMI (mean age 60 ± 11 years) underwent CMR at 1-3 days post-reperfusion (baseline) and at 4 months. Global peak systolic circumferential strain (GCS), measured by tagging and Feature Tracking (FT), and global peak systolic longitudinal strain (GLS), measured by FT, were calculated at baseline, along with IS...
January 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28049552/antiproliferative-cyclodepsipeptides-from-the-marine-actinomycete-streptomyces-sp-p11-23b-downregulating-the-tumor-metabolic-enzymes-of-glycolysis-glutaminolysis-and-lipogenesis
#10
Xuewei Ye, Komal Anjum, Tengfei Song, Wenling Wang, Ying Liang, Mengxuan Chen, Haocai Huang, Xiao-Yuan Lian, Zhizhen Zhang
Two cyclodepsipeptides and a known cyclodepsipeptide valinomycin were isolated from a culture of the marine actinomycete Streptomyces sp. P11-23B. Their structures were established based on NMR, HRESIMS, and MS-MS spectroscopic interpretation as well as by chemical degradation. Both streptodepsipeptides P11A and P11B inhibited proliferation of different glioma cell lines, with IC50 values ranging from 0.1 μM to 1.4 μM. Streptodepsipeptide P11A was found to block the cell cycle at the G0/G1 phase and induce apoptosis in glioma cells...
December 31, 2016: Phytochemistry
https://www.readbyqxmd.com/read/28033254/efficacy-of-an-early-home-based-cardiac-rehabilitation-program-for-patients-after-acute-myocardial-infarction-a-three-dimensional-speckle-tracking-echocardiography-randomized-trial
#11
Lin Xu, Zekun Cai, Meihua Xiong, Yekuo Li, Guoying Li, Yu Deng, William Kongto Hau, Shuo Li, Wenhua Huang, Jian Qiu
BACKGROUND: The effect of an early short-term home-based cardiac rehabilitation (CR) program on ventricular function in acute myocardial infarction (AMI) patients is not yet clear. The purpose of this study was to evaluate the efficacy of our CR program on the improvement of myocardial function using three-dimensional speckle tracking echocardiography (3D-STE) in AMI patients. METHODS: Fifty-two AMI patients were randomly assigned to 2 groups after discharge: the rehabilitation group, which participated in an early, home-based CR program, and the control group, which received only usual care...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28025579/associations-of-childhood-and-adult-obesity-with-left-ventricular-structure-and-function
#12
H Yang, Q L Huynh, A J Venn, T Dwyer, T H Marwick
BACKGROUND: Overweight and obesity are associated with left ventricular (LV) dysfunction. We sought whether echocardiographic evidence of abnormal adult cardiac structure and function was related to childhood or adult adiposity. METHODS: This study included 159 healthy individuals aged 7-15 years and followed until age 36-45 years. Anthropometric measurements were performed both at baseline and follow-up. Cardiac structure (indexed left atrial volume [LAVi], left ventricular mass [LVMi]) and LV function (global longitudinal strain [GLS], mitral e') were assessed using standard echocardiography at follow up...
December 27, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27968773/assessment-of-global-longitudinal-strain-at-low-dose-anthracycline-based-chemotherapy-for-the-prediction-of-subsequent-cardiotoxicity
#13
C Charbonnel, R Convers-Domart, S Rigaudeau, A-L Taksin, N Baron, J Lambert, S Ghez, J-L Georges, H Farhat, J Lambert, P Rousselot, B Livarek
OBJECTIVES: The aim of this study was to assess whether global longitudinal strain (GLS) measured early during treatment with anthracycline (at a cumulative dose of 150mg/m(2)) can predict subsequent alterations in left ventricular ejection fraction (LVEF). METHODS AND RESULTS: Eighty-six patients suffering from Hodgkin's disease, non-Hodgkin's lymphoma or acute leukemia and receiving anthracyclines were prospectively included. They underwent complete echocardiography on four separate occasions: baseline (V1); after reaching a cumulative dose of 150mg/m(2) (V2); end of treatment (V3); one year follow-up (V4)...
November 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27955938/global-and-regional-patterns-of-longitudinal-strain-in-screening-for-chemotherapy-induced-cardiotoxicity
#14
Guilherme Portugal, Luísa Moura Branco, Ana Galrinho, Miguel Mota Carmo, Ana Teresa Timóteo, Joana Feliciano, João Abreu, Sónia Duarte Oliveira, Lurdes Batarda, Rui Cruz Ferreira
INTRODUCTION: Serial echocardiographic assessment of left ventricular ejection fraction (LVEF) is the gold standard in screening for chemotherapy-induced cardiotoxicity (CIC). Measurement of myocardial deformation using speckle tracking enables more detailed assessment of myocardial contractility. The aim of this study was to determine the relationship between global and regional longitudinal strain and CIC. METHODS: This was a prospective study of 158 breast cancer patients undergoing chemotherapy with anthracyclines with or without adjuvant trastuzumab who underwent serial monitoring by transthoracic echocardiography with assessment of myocardial deformation...
January 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27955686/nutrigenomic-effects-of-glucosinolates-on-liver-muscle-and-distal-kidney-in-parasite-free-and-salmon-louse-infected-atlantic-salmon
#15
Stanko Skugor, Helle Jodaa Holm, Anne Kari Bjelland, Jorge Pino, Øystein Evensen, Aleksei Krasnov, Simon Wadsworth
BACKGROUND: Reduction of Lepeophtheirus salmonis infection in Atlantic salmon achieved by glucosinolates (GLs) from Brassica plants was recently reported. However, wider application of functional feeds based on GLs requires better knowledge of their positive and adverse effects. METHODS: Liver, distal kidney and muscle transcriptomes of salmon exposed to the extreme dose of GLs were profiled by microarray, while qPCR analysis followed up selected hepatic and renal responses under the extreme and moderate GLs dose during the L...
December 12, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27931524/blood-pressure-and-lv-remodeling-among-american-style-football-players
#16
Jeffrey Lin, Francis Wang, Rory B Weiner, James R DeLuca, Meagan M Wasfy, Brant Berkstresser, Gregory D Lewis, Adolph M Hutter, Michael H Picard, Aaron L Baggish
OBJECTIVES: This study sought to determine the relationships among American-style football (ASF) participation, acquired left ventricular (LV) hypertrophy, and LV systolic function as assessed using contemporary echocardiographic parameters. BACKGROUND: Participation in ASF has been associated with development of hypertension and LV hypertrophy. To what degree these processes impact LV function is unknown. METHODS: This was a prospective, longitudinal cohort study evaluating National Collegiate Athletic Association Division I football athletes stratified by field position (linemen: n = 30; vs...
December 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27931009/successful-mace-risk-stratification-in-hypertrophic-cardiomyopathy-patients-using-different-2d-speckle-tracking-tte-approaches
#17
Koya Ozawa, Nobusada Funabashi, Hiroyuki Takaoka, Yoshio Kobayashi
PURPOSE: We performed 2D speckle tracking transthoracic-echocardiography (TTE) to compare the ability to predict occurrence of major adverse cardiac events (MACE) between global longitudinal strain (GLS) and circumferential strain (GCS) in left ventricular (LV) myocardium in hypertrophic cardiomyopathy (HCM) patients without obstructed coronary arteries. METHODS: We measured 2D LV GLS and GCS retrospectively by TTE within 13months of performance of cardiac CT in 41 consecutive symptomatic HCM patients (27 males; 60±13years) without obstructed coronary arteries on CT...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27929411/a-robust-range-grating-lobe-suppression-method-based-on-image-contrast-for-stepped-frequency-sar
#18
Wen-Bin Gao, Teng Long, Ze-Gang Ding, Yi-Rong Wu
The magnitude error and phase error (MEPE) in the transfer function of a stepped-frequency synthetic aperture radar (SAR) system results in a periodic MEPE in the synthesized wideband waveform (SWW), which induces the grating lobes in the high-resolution range profile (HRRP). In this paper, a robust data-driven grating lobe suppression (GLS) method is proposed. Based on a contrast-based error estimation method and the grating lobes of the brightest scatterers in the SAR image, the periodic MEPE can be robustly estimated using the proposed method...
December 6, 2016: Sensors
https://www.readbyqxmd.com/read/27919244/surgical-antibiotic-prophylaxis-in-children-a-mixed-method-study-on-healthcare-professionals-attitudes
#19
Angela Giusti, Stefania Spila Alegiani, Marta Luisa Ciofi Degli Atti, Sofia Colaceci, Roberto Raschetti, Pasquale Arace, Raffaele Spiazzi, Massimiliano Raponi
BACKGROUND: Qualitative and quantitative research investigating determinants of adherence to clinical guidelines (GLs) on surgical antibiotic prophylaxis (SAP) are scarce. We conducted a mixed-method study aimed at investigating barriers and at describing attitudes of healthcare professionals (HCPs) regarding SAP in three Italian children's hospitals. METHODS: The study comprised two sequential phases: 1) collection of qualitative data through focus groups; 2) conduction of a survey on HCPs attitudes towards SAP...
December 5, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27910996/speckle-tracking-echocardiography-predicts-early-subclinical-anthracycline-cardiotoxicity-in-patients-with-breast-cancer
#20
Qi Tang, Yan Jiang, Yali Xu, Hongmei Xia
PURPOSE: This study aimed to assess the early changes of left ventricular (LV) and right ventricular (RV) mechanics associated with anthracycline treatment for breast cancer and to determine whether two-dimensional speckle tracking echocardiography (2D-STE) analysis could predict chemotherapy-induced cardiotoxicity. BACKGROUND: Anthracycline generates progressive LV dysfunction associated with a poor prognosis. Early detection of minor change of myocardial mechanics is thus important...
December 2, 2016: Journal of Clinical Ultrasound: JCU
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