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Sodium nitroprusside

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https://www.readbyqxmd.com/read/28068359/docosahexaenoic-acid-supplemented-diet-influences-the-orchidectomy-induced-vascular-dysfunction-in-rat-mesenteric-arteries
#1
Diva M Villalpando, Rocío Navarro, Lara Del Campo, Carlota Largo, David Muñoz, María Tabernero, Ramiro Baeza, Cristina Otero, Hugo S García, Mercedes Ferrer
Over the past few decades, the cardiovascular benefits of a high dietary intake of long-chain polyunsaturated fatty acids (PUFAs), like docosahexaenoic acid (DHA), have been extensively studied. However, many of the molecular mechanisms and effects exerted by PUFAs have yet to be well explained. The lack of sex hormones alters vascular tone, and we have described that a DHA-supplemented diet to orchidectomized rats improve vascular function of the aorta. Based on these data and since the mesenteric artery importantly controls the systemic vascular resistance, the objective of this study was to analyze the effect of a DHA-supplemented diet on the mesenteric vascular function from orchidectomized rats...
2017: PloS One
https://www.readbyqxmd.com/read/28064177/nitric-oxide-acts-upstream-of-ethylene-in-cell-wall-phosphorus-reutilization-in-phosphorus-deficient-rice
#2
Xiao Fang Zhu, Chun Quan Zhu, Chao Wang, Xiao Ying Dong, Ren Fang Shen
Nitric oxide (NO) and ethylene are both involved in cell wall phosphorus (P) reutilization in P-deficient rice; however, the crosstalk between them remains unclear. In the present study using P-deficient 'Nipponbare' (Nip), root NO accumulation significantly increased after 1 h and reached a maximum at 3 h, while ethylene production significantly increased after 3 h and reached a maximum at 6 h, indicating NO responded more quickly than ethylene. Irrespective of P status, addition of the NO donor sodium nitroprusside (SNP) significantly increased while the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (c-PTIO) significantly decreased the production of ethylene, while neither the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) nor the ethylene inhibitor aminoethoxyvinylglycine (AVG) had any influence on NO accumulation, suggesting NO acted upstream of ethylene...
January 7, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28057563/uric-acid-and-endothelial-function-in-elderly-community-dwelling-subjects
#3
Andrea Ticinesi, Fulvio Lauretani, Gian Paolo Ceda, Carmelinda Ruggiero, Luigi Ferrucci, Rosalia Aloe, Anders Larsson, Tommy Cederholm, Lars Lind, Tiziana Meschi, Marcello Maggio
The role of serum uric acid (SUA), an inflammatory agent and potential mediator of cardiovascular diseases, in Endothelial Function (EF) has been tested only in middle-aged subjects affected by specific diseases. Our aim was to assess the relationship between SUA and measures of EF in a cohort of elderly community-dwellers. This study involved 424 males and 426 females aged 70years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), having complete data on SUA and EF assessed by flow-mediated vasodilation (FMD) and by intra-arterial infusion of acetylcholine (endothelium-dependent vasodilation, EDV) and sodium nitroprusside (endothelium-independent vasodilation, EIDV)...
January 2, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28052641/protective-effects-of-melatonin-on-the-activity-of-sod-cat-gsh-px-and-gsh-content-in-organs-of-mice-after-administration-of-snp
#4
Zofia Goc, Waldemar Szaroma, Edyta Kapusta, Karol Dziubek
Sodium nitroprusside (SNP) is an antihypertensive drug with proven dose-dependent toxic effects attributed mainly to the production of cyanide but also excesive nitric oxide (NO) and derived reactive species. The present study evaluated whether melatonin administration would have time-dependent protective effect against SNP−induced toxicity. Male Swiss mice were used in this study. Control mice were treated with 0.9% NaCl; the second group was injected with 10 mg melatonin (MEL)/kg body weight (b.w.); the third group was given SNP at the dose of 3,6 mg/kg b...
28, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28030779/nitric-oxide-improves-s-assimilation-and-gsh-production-to-prevent-inhibitory-effects-of-cadmium-stress-on-photosynthesis-in-mustard-brassica-juncea-l
#5
Tasir S Per, Asim Masood, Nafees A Khan
Nitric oxide (NO) is an important gaseous signalling molecule that participates in many developmental and physiological processes, including defense responses against toxic metals in plants. The role of NO in cadmium (Cd)-induced toxic effects on photosynthesis was examined in mustard (Brassica juncea L.) plants. Exposure of plants to 50 μM Cd significantly enhanced oxidative stress (H2O2 content and lipid peroxidation) and impaired plant growth and photosynthesis, chlorophyll fluorescence and reduced chlorophyll content and stomatal conductance...
December 25, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28024456/thrombospondin-1-mediates-multi-walled-carbon-nanotube-induced-impairment-of-arteriolar-dilation
#6
W Kyle Mandler, Timothy R Nurkiewicz, Dale W Porter, I Mark Olfert
Pulmonary exposure to multi-walled carbon nanotubes (MWCNT) has been shown to disrupt endothelium-dependent arteriolar dilation in the peripheral microcirculation. The molecular mechanisms behind these arteriolar disruptions have yet to be fully elucidated. The secreted matricellular matrix protein thrombospondin-1 (TSP-1) is capable of moderating arteriolar vasodilation by inhibiting soluble guanylate cyclase activity. We hypothesized that TSP-1 may be a link between nanomaterial exposure and observed peripheral microvascular dysfunction...
December 26, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/28018295/combined-whole-cell-high-throughput-functional-screening-for-identification-of-new-nicotinamidases-pyrazinamidases-in-metagenomic-polygenomic-libraries
#7
Rubén Zapata-Pérez, Antonio G García-Saura, Mohamed Jebbar, Peter N Golyshin, Álvaro Sánchez-Ferrer
Nicotinamidases catalyze the hydrolysis of the amide bond in nicotinamide (NAM) to produce ammonia and nicotinic acid (NA). These enzymes are an essential component of the NAD(+) salvage pathway and are implicated in the viability of several pathogenic organisms. Its absence in humans makes them a promising drug target. In addition, although they are key analytical biocatalysts for screening modulators in relevant biomedical enzymes, such as sirtuins and poly-ADP-ribosyltransferases, no commercial sources are available...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28013386/potentiation-of-the-no-cgmp-pathway-and-blood-flow-responses-during-dynamic-exercise-in-healthy-humans
#8
Jacqueline K Limberg, Katherine R Malterer, J Mikhail Kellawan, William G Schrage, Brad W Wilkins, Wayne T Nicholson, John H Eisenach, Michael J Joyner, Timothy B Curry
PURPOSE: Previous work has shown nitric oxide (NO) contributes to ~15% of the hyperemic response to dynamic exercise in healthy humans. This NO-mediated vasodilation occurs, in part, via increases in intracellular cyclic guanosine monophosphate (cGMP), which is catabolized by phosphodiesterase. We sought to examine the effect of phosphodiesterase-5 (PDE-5) inhibition on forearm blood flow (FBF) responses to dynamic handgrip exercise in healthy humans and the role of NO. We hypothesized exercise hyperemia would be augmented by sildenafil citrate (SDF, PDE-5 inhibitor)...
December 24, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28011166/hyperglycemia-and-high-nitric-oxide-level-induced-oxidative-stress-in-the-brain-and-molecular-alteration-in-the-neurons-and-glial-cells-of-laboratory-mouse-mus-musculus
#9
Rashmi Richa, Arun Kumar Yadawa, Chandra Mohini Chaturvedi
Chronic hyperglycemia (glucotoxicity) is reported to have detrimental effects on various brain functions leading to neurodegenerative changes. However, the effect of hyperglycemia in combination with high nitric oxide (NO) level (reported to be increased during glucotoxicity), on brain functions is not clear yet. The present study was designed to investigate the effects of hyperglycemic drug Streptozotocin (STZ) and NO donor Sodium nitroprusside (SNP) on the brain of laboratory mouse, Mus musculus. Effects of these conditions were studied on the markers of oxidative stress, NF-κB signalling and the markers of neuronal and glial cell activation/inflammation...
December 20, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/28008617/n-cadherin-a-novel-and-rapidly-remodelling-site-involved-in-vasoregulation-of-small-cerebral-arteries
#10
Zhe Sun, Min Li, Zhaohui Li, Michael A Hill, Gerald A Meininger
N-cadherin is the major cell-cell adhesion molecule in vascular smooth muscle cells (VSMC). We tested the hypothesis that N-cadherin is part of a novel mechano-sensory mechanism in VSMC and plays an active role in both the arteriolar myogenic response and during changes in vascular tone induced by vasomotor agonists. Intact and pressurized rat superior cerebellar arteries (SCA) were labelled for confocal immunofluorescence imaging. N-cadherin formed punctate adherens junctions (AJ) along the borders between VSMC...
December 23, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/28006941/early-changes-of-brain-perfusion-after-subarachnoid-hemorrhage-the-effect-of-sodium-nitroprusside
#11
M Kolar, K Nohejlova, J Mares, J Pachl
Causes of early hypoperfusion after subarachnoid hemorrhage (SAH) include intracranial hypertension as well as vasoconstriction. The aim of the study was to assess the effect of intracerebroventricular (ICV) administration of sodium nitroprusside (SNP) on early hypoperfusion after SAH. Male Wistar rats (220-240 g) were used, SAH group received 250 microl of fresh autologous arterial blood into the prechiasmatic cistern; sham-operated animals received 250 microl of isotonic solution. Therapeutic intervention: ICV administration of 10 microg SNP; 5 microl 5 % glucose (SNP vehicle) and untreated control...
December 22, 2016: Physiological Research
https://www.readbyqxmd.com/read/28000045/nitrosative-stress-response-in-vibrio-cholerae-role-of-s-nitrosoglutathione-reductase
#12
Sourav Kumar Patra, Prasanta Kumar Bag, Sanjay Ghosh
Vibrio cholerae, the causative agent of cholera, poses serious threats to humans worldwide. V. cholerae faces host inflammatory response and encounters nitrosative stress before establishing successful colonization. It is not clear how V. cholerae combats nitric oxide and reactive nitrogen species. In the present study, we used three clinical strains of V. cholerae and tested their nitrosative stress response pattern towards sodium nitroprusside (SNP) and S-Nitrosoglutathione (GSNO). Among them, V. cholerae, belonging to both O1 and O139 serotypes, showed moderate resistance to SNP and GSNO...
December 20, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27984129/aluminum-exposure-for-one-hour-decreases-vascular-reactivity-in-conductance-and-resistance-arteries-in-rats
#13
Patrícia Medeiros Schmidt, Alyne Goulart Escobar, João Guilherme Dini Torres, Caroline Silveira Martinez, Danize Aparecida Rizzetti, Simone Noremberg Kunz, Dalton Valentim Vassallo, María Jesús Alonso, Franck Maciel Peçanha, Giulia Alessandra Wiggers
AIMS: Aluminum (Al) is an important environmental contaminant; however, there are not enough evidences of Al-induced cardiovascular dysfunction. We investigated the effects of acute exposure to aluminum chloride (AlCl3) on blood pressure, vascular reactivity and oxidative stress. METHODS AND RESULTS: Male Wistar rats were divided into two groups: Untreated: vehicle (ultrapure water, ip) and AlCl3: single dose of AlCl3 (100mg/kg,ip). Concentration-response curves to phenylephrine in the absence and presence of endothelium, the nitric oxide synthase inhibitor L-NAME, the potassium channels blocker tetraethylammonium, and the NADPH oxidase inhibitor apocynin were performed in segments from aortic and mesenteric resistance arteries...
October 27, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27983540/plasma-nitric-oxide-level-is-correlated-with-microvascular-functions-in-the-peripheral-arterial-disease
#14
Muzaffer Akkoca, Suzan Emel Usanmaz, Cuneyt Koksoy, Ugur Bengisun, Emine Demirel-Yilmaz
At present there is no widely accepted biomarker for monitoring of vascular functions. The purpose of this prospective study was to investigate the association of some blood biomarkers with vascular reactivity in patients with peripheral arterial diseases (PAD). A prospective evaluation was made of 3 groups comprising a control group of healthy individuals, and patients with PAD caused by either atherosclerosis or Buerger's disease. Microvascular perfusion was examined using laser Doppler imaging of cutaneous erythrocyte flux after iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP)...
December 14, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27979489/changes-in-cholinergic-and-nitrergic-systems-of-defunctionalized-colons-after-colostomy-in-rabbits
#15
Serdar Moralıoğlu, İsmail Mert Vural, İbrahim Onur Özen, Gökçe Öztürk, Yusuf Sarıoğlu, Abdullah Can Başaklar
BACKGROUND: This study was designed to assess smooth muscle function and motility in defunctionalized colonic segments and subsequent changes in pathways responsible for gastrointestinal motility. METHODS: Two-month-old New Zealand rabbits were randomly allocated into control and study groups. Sigmoid colostomies were performed in the study group. After a 2-month waiting period, colonic segments were harvested in both groups. For the in vitro experiment, the isolated circular muscle strips which were prepared from the harvested distal colon were used...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27956121/cardiovascular-dysfunction-associated-with-neurodegeneration-in-an-experimental-model-of-parkinson-s-disease
#16
Barbara Falquetto, Marina Tuppy, Simone R Potje, Thiago S Moreira, Cristina Antoniali, Ana C Takakura
Patients with Parkinson's disease (PD) exhibit both motor and non-motor symptoms. Among the non-motor symptoms, cardiovascular autonomic dysfunction is frequently observed. Here, we evaluated baroreflex function, vascular reactivity and neuroanatomical changes in brainstem regions involved in the neural control of circulation in the 6-hydroxydopamine (6-OHDA) model of PD. Male Wistar rats received a bilateral injection of 6-OHDA or vehicle into the striatum. After 61 days, baroreflex function and vascular reactivity were assessed...
December 9, 2016: Brain Research
https://www.readbyqxmd.com/read/27940267/nitric-oxide-protects-carbon-assimilation-process-of-watermelon-from-boron-induced-oxidative-injury
#17
Mohamed Farag, Ullah Najeeb, Jinghua Yang, Zhongyuan Hu, Zhang Ming Fang
Nitric oxide (NO) mediates plant response to a variety of abiotic stresses; however, limited information is available on its effect on boron (B)-stressed watermelon plants. The present study investigates the mechanism through which NO protects watermelon seedlings from B deficiency and toxicity stresses. Five days old watermelon seedlings were exposed to B (0, 0.5 and 10 mg L(-1)) alone or with 75 μmole of NO donor sodium nitroprusside (SNP) for 30 days. Both low and high B concentrations in the media altered nutrient accumulation and impaired various physiological processes of watermelon seedlings, leading to a significant reduction in biomass production...
November 30, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27935981/sympathetic-hyperactivity-increased-tyrosine-hydroxylase-and-exaggerated-corpus-cavernosum-relaxations-associated-with-oxidative-stress-plays-a-major-role-in-the-penis-dysfunction-in-townes-sickle-cell-mouse
#18
Fábio H Silva, Mário A Claudino, Fabiano B Calmasini, Eduardo C Alexandre, Carla Franco-Penteado, Arthur L Burnett, Edson Antunes, Fernando F Costa
BACKGROUND: Sickle cell disease patients display priapism that may progress to erectile dysfunction. However, little is known about the pathophysiological alterations of corpus cavernosum in sickle cell disease. OBJECTIVE: Thus, this study aimed to evaluate the functional and molecular alterations of sympathetic machinery and nitric oxide-cyclic guanosine monophosphate signaling pathway in Townes transgenic sickle cell disease mice. METHODS: Concentration-response curves to contractile (phenylephrine) and relaxant agents (acetylcholine and sodium nitroprusside) were obtained in corpus cavernosum strips from sickle and C57BL/6 (control) mice...
2016: PloS One
https://www.readbyqxmd.com/read/27931266/letter-to-the-editor-sodium-nitroprusside-for-schizophrenia-could-methodological-variables-account-for-the-different-results-obtained
#19
J P Maia-de-Oliveira, G B Baker, S M Dursun, J E C Hallak
No abstract text is available yet for this article.
December 9, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27921397/nitric-oxide-induced-by-polyamines-involves-antioxidant-systems-against-chilling-stress-in-tomato-lycopersicon-esculentum-mill-seedling
#20
Qian-Nan Diao, Yong-Jun Song, Dong-Mei Shi, Hong-Yan Qi
Polyamines (PAs) and nitric oxide (NO) are vital signals in modulating plant response to abiotic stress. However, to our knowledge, studies on the relationship between NO and PAs in response to cold stress in tomato are limited. Accordingly, in this study, we investigated the effects of putrescine (Put) and spermidine (Spd) on NO generation and the function of Spd-induced NO in the tolerance of tomato seedling under chilling stress. Spd increased NO release via the nitric oxide synthase (NOS)-like and nitrate reductase (NR) enzymatic pathways in the seedlings, whereas Put had no such effect...
2016: Journal of Zhejiang University. Science. B
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