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Sodium nitroprusside

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https://www.readbyqxmd.com/read/29151069/nitroso-sulfide-coupled-signaling-triggers-specific-vasoactive-effects-in-the-intrarenal-arteries-of-patients-with-arterial-hypertension
#1
S Cacanyiova, A Berenyiova, P Balis, F Kristek, M Grman, K Ondrias, J Breza, J Breza
In normotensive conditions, it has been confirmed that S-nitrosothiols (RSNO), can interact with hydrogen sulfide (H2S) and create new substances with specific vasoactive effects. This interaction could also represent a new regulator signaling pathway in conditions of hypertension. Until now, these effects were studied only in normotensive rats, and they have not been carried out in humans yet. We investigated the vasoactive effects of the products of the H2S/S-nitrosoglutathione (S/GSNO) interaction in lobar arteries (LA) isolated from the nephrectomized kidneys of patients suffering from arterial hypertension and in renal arteries (RA) of spontaneously hypertensive rats (SHR)...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29150514/sinorhizobium-meliloti-glutathione-reductase-is-required-for-both-redox-homeostasis-and-symbiosis
#2
Guirong Tang, Ningning Li, Yumin Liu, Liangliang Yu, Junhui Yan, Li Luo
Glutathione (L-γ-glutamyl-L-cysteinylglycine; GSH), one of the key antioxidants in Sinorhizobium meliloti, is required for the development of alfalfa (Medicago sativa) nitrogen-fixing nodules. Glutathione exists either in a reduced form (GSH) or an oxidized form (GSSG), and its content is regulated by two pathways in S. meliloti The first pathway is the de novo synthesis of glutathione from its constituent amino acids, namely, Glu, Cys, and Gly, catalyzed by γ-glutamyl cysteine synthetase (GshA) and glutathione synthetase (GshB)...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29146864/acute-hypoxia-reoxygenation-and-vascular-oxygen-sensing-in-the-chicken-embryo
#3
Riazuddin Mohammed, Carlos E Salinas, Dino A Giussani, Carlos E Blanco, Angel L Cogolludo, Eduardo Villamor
Fetal/perinatal hypoxia is one of the most common causes of perinatal morbidity and mortality and is frequently accompannied by vascular dysfunction. However, the mechanisms involved have not been fully delineated. We hypothesized that exposure to acute hypoxia-reoxygenation induces alterations in vascular O2 sensing/signaling as well as in endothelial function in the chicken embryo pulmonary artery (PA), mesenteric artery (MA), femoral artery (FA), and ductus arteriosus (DA). Noninternally pipped 19-day embryos were exposed to 10% O2 for 30 min followed by reoxygenation with 21% O2 or 80% O2 Another group was constantly maintained at 21% O2 or at 21% O2 for 30 min and then exposed to 80% O2 Following treatment, responses of isolated blood vessels to hypoxia as well as endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside and forskolin) relaxation were investigated in a wire myograph...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29146157/angiotensin-converting-enzyme-2-activation-ameliorates-pulmonary-endothelial-dysfunction-in-rats-with-pulmonary-arterial-hypertension-through-mediating-phosphorylation-of-endothelial-nitric-oxide-synthase
#4
Gang Li, Han Zhang, Lei Zhao, Yaozhong Zhang, Daole Yan, Yinglong Liu
This study aims to investigate the effect of angiotensin-converting enzyme 2 (ACE2) activation on pulmonary endothelial function in the process of preventing pulmonary arterial hypertension (PAH) in rat models and to explore the underlying mechanisms. Specific pathogen free rats were randomly divided into five groups including control group, PAH group, PAH + Resorcinolnaphthalein (Res) group (ACE2 activation), PAH + Res + MLN4760 group (ACE2 inhibition), and PAH + Res + L-NAME group (endothelial nitric oxide synthase [eNOS] inhibition)...
October 28, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29141949/microvascular-insulin-resistance-in-skeletal-muscle-and-brain-occurs-early-in-the-development-of-juvenile-obesity-in-pigs
#5
T Dylan Olver, Zachary Ian Grunewald, Thomas J Jurrissen, Rebecca Ek MacPherson, Paul J LeBlanc, Teagan R Schnurbusch, Alana M Czajkowski, Maurice Harold Laughlin, R Scott Rector, Shawn B Bender, Eric M Walters, Craig A Emter, Jaume Padilla
BACKGROUND: Impaired microvascular insulin signaling may develop prior to overt indices of microvascular endothelial dysfunction and represent an early pathological feature of adolescent obesity. Using a translational porcine model of juvenile obesity, we tested the hypotheses that in the early stages of obesity development, impaired insulin signaling manifests in skeletal muscle (triceps), brain (prefrontal cortex) and corresponding vasculatures, and that depressed insulin-induced vasodilation is reversible with acute inhibition of protein kinase C beta (PKCβ)...
November 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29122812/nebivolol-but-not-metoprolol-treatment-improves-endothelial-fibrinolytic-capacity-in-adults-with-elevated-blood-pressure
#6
Brian L Stauffer, Caitlin A Dow, Kyle J Diehl, Tyler D Bammert, Jared J Greiner, Christopher A DeSouza
BACKGROUND: Vascular endothelial fibrinolytic function is impaired in adults with prehypertension and hypertension and plays a mechanistic role in the development of atherothrombotic events. The influence of β-blockers on endothelial fibrinolysis is unknown. This study compared the effects of chronic nebivolol and metoprolol treatment on endothelial tissue-type plasminogen activator (t-PA) release in adults with elevated blood pressure (BP). METHODS AND RESULTS: Forty-four middle-aged adults (36% women) with elevated BP completed a 3-month, double-blind, randomized, placebo-controlled trial comparing nebivolol (5 mg/d), metoprolol succinate (100 mg/d), and placebo...
November 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29121802/hispolon-suppresses-lps-or-lta-induced-inos-no-production-and-apoptosis-in-bv-2-microglial-cells
#7
Ming-Shun Wu, Chih-Chiang Chien, Kur-Ta Cheng, Gottumukkala V Subbaraju, Yen-Chou Chen
Hispolon (HIS) is an active polyphenol compound derived from Phellinus linteus (Berkeley & Curtis), and our previous study showed that HIS effectively inhibited inflammatory responses in macrophages (Yang et al., 2014); however, its effect on neuronal inflammation is still undefined. In this study, HIS concentration- and time-dependently inhibited lipopolysaccharide (LPS)- and lipoteichoic acid (LTA)-induced inducible nitric oxide (NO) synthase (iNOS)/NO production with increased heme oxygenase (HO)-1 proteins in BV-2 microglial cells...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29117995/the-role-of-mitochondria-derived-reactive-oxygen-species-in-microvascular-dysfunction-in-chronic-kidney-disease
#8
Danielle L Kirkman, Bryce J Muth, Meghan G Ramick, Raymond R Townsend, David G Edwards
Cardiovascular disease is the leading cause of mortality in Chronic Kidney Disease (CKD). Mitochondrial dysfunction secondary to CKD is a potential source of oxidative stress that may impair vascular function. This study sought to determine if mitochondria derived reactive oxygen species contribute to microvascular dysfunction in Stage 3-5 CKD. Cutaneous vasodilation in response to local heating was assessed in 20 CKD patients (60±13 years; eGFR 46±13ml/kg/1.73m2) and eleven matched healthy participants (58±2 years; eGFR>90ml/kg/1...
November 8, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29101035/surfactant-protein-d-attenuates-nitric-oxide-stimulated-apoptosis-in-rat-chondrocyte-by-suppressing-p38-mapk-signaling
#9
Yan Zhou, Jianghua Ming, Yaming Li, Xianjin Du, Ming Deng, Bin He, Jianlin Zhou, Guirong Wang, Shiqing Liu
Innate immune molecule surfactant protein D (SP-D), a member of the C-type lectin protein family, plays an indispensable role in host defense and the regulation of inflammation in the lung and other tissues. Osteoarthritis (OA) is a degenerative disease of cartilage, with inflammation that causes pathologic changes and tissue damage. However, it is unknown whether there exist SP-D expression and its potential role in the pathogenesis of OA. In this study, we examined SP-D expression and explored its biological function in a sodium nitroprusside (SNP)-stimulated rat chondrocytes and surgically-induced rat OA model...
October 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29097631/chronic-exposure-to-electronic-cigarette-e-cig-results-in-impaired-cardiovascular-function-in-mice
#10
I Mark Olfert, Evan DeVallance, Hannah Hoskinson, Kayla W Branyan, Stuart Clayton, Christopher R Pitzer, David Patrick Sullivan, Matthew J Breit, Zhong-Xin Wu, Powsiri Klinkhachorn, W Kyle Mandler, Brett H Erdreich, Barbara S Ducatman, Randy W Bryner, Piyali Dasgupta, Paul D Chantler
Proponents for electronic cigarettes(E-cigs) claim they are a safe alternative to smoking tobacco-based cigarettes,however little is known about the long-term effects of E-cig vapor exposure on vascular function.The purpose of this study was to determine the cardiovascular consequences of chronic E-cig exposure. Female mice (C57Bl/6 background strain)were randomly assigned to chronic daily exposure of E-cig vapor, standard cigarette smoke(using 3R4F-reference-cigarette), or filtered-air(N=15/group). Respective whole-body exposures consisted of 4 x 1-hour exposure blocks, separated by 30-minute intervals of fresh air breaks, resulting in intermittent daily exposure for a total of 4h/day, 5days/week for 8-months...
November 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29096831/endothelial-function-and-gene-expression-in-perivascular-adipose-tissue-from-internal-mammary-arteries-of-obese-patients-with-coronary-artery-disease
#11
Maria Cybularz, Heike Langbein, Birgit Zatschler, Coy Brunssen, Andreas Deussen, Klaus Matschke, Henning Morawietz
BACKGROUND AND AIMS: Obesity is a risk factor for endothelial dysfunction and atherosclerosis. However, perivascular adipose tissue can release adipokines and other unknown adipose-derived relaxing factors. Therefore, we investigated the impact of obesity on vascular function and expression of genes in perivascular adipose tissue from internal mammary arteries of patients with coronary artery disease undergoing coronary artery bypass grafting. METHODS: The vessel function was compared between groups of patients with a body-mass index (BMI) between 25 and 30 kg/m(2)...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29095915/interaction-of-il-6-and-tnf-%C3%AE-contributes-to-endothelial-dysfunction-in-type-2-diabetic-mouse-hearts
#12
Jonghae Lee, Sewon Lee, Hanrui Zhang, Michael A Hill, Cuihua Zhang, Yoonjung Park
OBJECTIVES: Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), are individually considered as important contributors to endothelial dysfunction in obesity and type 2 diabetes (T2D). However, their interactions in coronary arteriole endothelial dysfunction are uncertain. Therefore, this study aimed to determine the effects of TNF-α and IL-6 interactions on coronary endothelial dysfunction in experimental T2D. METHODS: The studies used wild type (WT), diabetic mice (db/db), db/db null for TNF (dbTNF-/dbTNF-), and db/db mice treated with neutralizing antibody to IL-6 (anti-IL-6)...
2017: PloS One
https://www.readbyqxmd.com/read/29095897/a-novel-experimental-model-of-erectile-dysfunction-in-rats-with-heart-failure-using-volume-overload
#13
Fábio Henrique Silva, Frederico José Reis Veiga, Aline Gonçalves Mora, Rodrigo Sader Heck, Caroline Candida De Oliveira, Alessandra Gambero, Carla Fernanda Franco-Penteado, Edson Antunes, Jason D Gardner, Fernanda Bruschi Marinho Priviero, Mário Angelo Claudino
BACKGROUND: Patients with heart failure (HF) display erectile dysfunction (ED). However, the pathophysiology of ED during HF remains poorly investigated. OBJECTIVE: This study aimed to characterize the aortocaval fistula (ACF) rat model associated with HF as a novel experimental model of ED. We have undertaken molecular and functional studies to evaluate the alterations of the nitric oxide (NO) pathway, autonomic nervous system and oxidative stress in the penis...
2017: PloS One
https://www.readbyqxmd.com/read/29093428/danshen-attenuates-cartilage-injuries-in-osteoarthritis-in-vivo-and-in-vitro-by-activating-jak2-stat3-and-akt-pathways
#14
Xilin Xu, Hang Lv, Xiaodong Li, Hui Su, Xiaofeng Zhang, Jun Yang
Articular cartilage degradation is a main feature of osteoarthritis (OA). The effects of Danshen, a traditional Chinese herb, in mitigating cartilage damage have been reported before. This study was conducted to investigate the effects of Danshen on cartilage injuries in OA. Rabbit OA models were established by surgical destabilization of the medial meniscus and the anterior and posterior cruciate ligaments in the left knee joint. Injection of Danshen into the articular cavity attenuated OA cartilage destruction in vivo...
October 31, 2017: Experimental Animals
https://www.readbyqxmd.com/read/29072344/the-effect-of-sex-and-prematurity-on-the-cardiovascular-baroreflex-response-in-sheep
#15
Beth J Allison, Vivian Nguyen, Stephanie R Yiallourou, Ilias Nitsos, Mary Jane Black, Graeme R Polglase
Very preterm infants have an increased risk of cardiovascular disease, however the effects of a late preterm birth on future cardiovascular function are not known. We hypothesized that well describes impairments in heart rate variability and baroreflex sensitivity would persist into adulthood following a late preterm birth. To test this hypothesis sheep born preterm (0.9 gestation: 9M, 7F) or term (11M, 6F) underwent surgery at 14 months of age for insertion of femoral arterial and venous catheters and femoral flow probe...
October 26, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29071893/-influence-of-electroacupuncture-intervention-on-glutamic-acid-and-ca-2-contents-and-expression-of-nmda-receptor-protein-in-hippocampus-in-vascular-dementia-rats
#16
Qian Zhang, Chuang Zhang, Jia-Yin Zhang, Hui-Zhen Zhang, Xiao-Feng Li, Hong-Ling Xiao, Yan-Hui Sun, Hai-Jiao Xing, Xiao-Kang Xu, Yu-Lei Liang, Xin Zhang, Xiao-Qi Zhang, Ai-Ying Li
OBJECTIVE: To observe the influence of electroacupuncture (EA) intervention on hippocampal glutamate (Glu) and Ca(2+) contents, and expression of Glu-N-methyl-D-aspartic acid receptor(NMDAR) and the learning-memory ability in vascular dementia (VD) rats, so as to reveal its mechanisms underlying improvement of VD. METHODS: SD rats were rando-mized into sham operation (sham) group (n=9), model group (n=11) and EA groups (n=10). The VD model was established by repeated bilateral common carotid arteries occlusion and reperfusion plus intraperitoneal injection of sodium nitroprusside...
December 25, 2016: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29042424/angiotensin-ii-receptor-neprilysin-inhibitor-sacubitril-valsartan-improves-endothelial-dysfunction-in-spontaneously-hypertensive-rats
#17
Takunori Seki, Kenichi Goto, Yasuo Kansui, Toshio Ohtsubo, Kiyoshi Matsumura, Takanari Kitazono
BACKGROUND: We have previously demonstrated that antihypertensive treatment with renin-angiotensin system inhibitors restores the impaired endothelium-dependent hyperpolarization (EDH)-mediated responses in spontaneously hypertensive rats (SHRs). Herein, we investigated whether the angiotensin II receptor-neprilysin inhibitor sacubitril/valsartan (LCZ696) would improve reduced EDH-mediated responses and whether LCZ696 would exert additional effects on endothelium-dependent and endothelium-independent vasorelaxation compared with an angiotensin II type 1 receptor blocker alone during hypertension...
October 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29028538/nitric-oxide-induces-rice-tolerance-to-excessive-nickel-by-regulating-nickel-uptake-reactive-oxygen-species-detoxification-and-defense-related-gene-expression
#18
Muhammad Rizwan, Mohammad Golam Mostofa, Muhammad Zulfiqar Ahmad, Muhammad Imtiaz, Sajid Mehmood, Muhammad Adeel, Zhihua Dai, Zheyong Li, Omar Aziz, Yihui Zhang, Shuxin Tu
Soil contamination with nickel (Ni) is a persistent threat to crop production worldwide. The present study examined the putative roles of nitric oxide (NO) in improving Ni-tolerance in rice. Our findings showed that application of exogenous sodium nitroprusside (SNP), a NO donor, significantly improved the growth performance of rice seedlings when grown under excessive Ni. The enhanced Ni-tolerance of rice prompted by SNP could be ascribed to its ability to regulate Ni uptake, decrease Ni-induced oxidative stress as evidenced by reduced levels of hydrogen peroxide, malondialdehyde, and electrolyte leakage in Ni-stressed plants...
September 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/29027929/procyanidin-b2-protects-neurons-from-oxidative-nitrosative-and-excitotoxic-stress
#19
Taylor C Sutcliffe, Aimee N Winter, Noelle C Punessen, Daniel A Linseman
The aberrant generation of oxygen and nitrogen free radicals can cause severe damage to key cellular components, resulting in cell apoptosis. Similarly, excitotoxicity leads to protease activation and mitochondrial dysfunction, which subsequently causes cell death. Each of these factors play critical roles in the neuronal cell death underlying various neurodegenerative diseases. Procyanidin B2 (PB2) is a naturally occurring polyphenolic compound found in high concentrations in cocoa, apples, and grapes. Here, we examine the neuroprotective effects of PB2 in primary cultures of rat cerebellar granule neurons (CGNs) exposed to various stressors...
October 13, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29027818/effects-of-nesfatin-1-on-atrial-contractility-and-thoracic-aorta-reactivity-in-male-rats
#20
Ayşe Barutcigil, Arda Tasatargil
BACKGROUND: This study aimed to examine the effects of nesfatin-1 on thoracic aorta vasoreactivity and to investigate the inotropic and chronotropic effects of nesfatin-1 on the spontaneous contractions of the isolated rat atria. METHODS: Isolated right atria and thoracic aorta were used in organ baths. The reactivity of the thoracic aorta was evaluated by potassium chloride (KCl), phenylephrine (Phe), acetylcholine (ACh), and sodium nitroprusside (SNP). The effects of nesfatin-1 on the spontaneous contractions of the rat atria were also examined...
October 13, 2017: Clinical and Experimental Hypertension: CHE
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