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Sodium nitroprusside

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https://www.readbyqxmd.com/read/29320529/how-exogenous-nitric-oxide-regulates-nitrogen-assimilation-in-wheat-seedlings-under-different-nitrogen-sources-and-levels
#1
Sadegh Balotf, Shahidul Islam, Gholamreza Kavoosi, Bahman Kholdebarin, Angela Juhasz, Wujun Ma
Nitrogen (N) is one of the most important nutrients for plants and nitric oxide (NO) as a signaling plant growth regulator involved in nitrogen assimilation. Understanding the influence of exogenous NO on nitrogen metabolism at the gene expression and enzyme activity levels under different sources of nitrogen is vitally important for increasing nitrogen use efficiency (NUE). This study investigated the expression of key genes and enzymes in relation to nitrogen assimilation in two Australian wheat cultivars, a popular high NUE cv...
2018: PloS One
https://www.readbyqxmd.com/read/29317251/organoselenium-group-is-critical-for-antioxidant-activity-of-7-chloro-4-phenylselenyl-quinoline
#2
Ane G Vogt, Guilherme T Voss, Renata L de Oliveira, Jaini J Paltian, Luis F B Duarte, Diego Alves, Cristiano R Jesse, Silvane S Roman, Juliano A Roehrs, Ethel A Wilhelm, Cristiane Luchese
The quinolone compounds have been reported for many biological properties, especially as potent antioxidants. This study investigated the antioxidant effect of 7-chloro-4-phenylselenyl-quinoline (PSQ), a quinolone derivative with organoselenium group, against oxidative stress induced by sodium nitroprusside (SNP) in brains of mice. A second objective was to verify the importance of phenylselenyl group presents at position 4 of the quinoline structure to antioxidant effect of compound. So, it was compared the antioxidant effect of PSQ with a quinoline without organoseleniun group (7-chloroquinoline [QN])...
January 6, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29315929/wd40-repeat-5a-represses-root-meristem-growth-by-suppressing-auxin-synthesis-through-changes-of-nitric-oxide-accumulation-in-arabidopsis
#3
Wen-Cheng Liu, Si-Qiu Zheng, Zhen-Dong Yu, Xiang Gao, Ran Shen, Ying-Tang Lu
While nitric oxide (NO) is known to regulate root growth, the factor(s) modulating NO during this process have not yet been elucidated. Here, we identified Arabidopsis WD40-REPEAT 5a (WDR5a) as a novel factor that functions in root growth by modulating NO accumulation. The wdr5a-1 mutant accumulated less NO and produced longer roots than the wild type, while the WDR5a overexpression lines had the opposite phenotype. The role of NO was further supported by our observation that the NO donor sodium nitroprusside (SNP) and the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO) rescued the root meristem growth phenotypes of the wdr5a-1 and WDR5a overexpression lines, respectively...
January 6, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29309132/glutathionylation-inhibits-catalytic-activity-of-arabidopsis-%C3%AE-amylase3-but-not-paralog-%C3%AE-amylase1
#4
Amanda R Storm, Matthew R Kohler, Christopher E Berndsen, Jonathan D Monroe
β-amylase3 (BAM3) is an enzyme essential for starch degradation in plant leaves and is also transcriptionally-induced under cold stress. However, we recently reported that BAM3's enzymatic activity decreased in cold-stressed Arabidopsis leaves, although activity of BAM1, a homologous leaf β-amylase was largely unaffected. This decrease in BAM3 activity may relate to starch accumulation reported in cold-stressed plants. The aim of this study was to explore the disparity between BAM3 transcript and activity levels under cold stress and we present evidence suggesting BAM3 is being inhibited by post-translational modification (PTM)...
January 8, 2018: Biochemistry
https://www.readbyqxmd.com/read/29307093/vasodilator-function-worsens-after-cessation-of-tumour-necrosis-factor-inhibitor-therapy-in-patients-with-rheumatoid-arthritis-only-if-a-flare-occurs
#5
Gerard A Rongen, Iris van Ingen, Marc Kok, Harald Vonkeman, Matthijs Janssen, Tim L Jansen
Vasodilator function is reported to be reduced in rheumatoid arthritis (RA), and is considered an early sign of vascular dysfunction, which is normalised by TNF inhibitors (TNFi). To optimise cost-effectiveness, tapering or interruption of TNFi therapy in established RA patients is advocated. We explored whether cessation of TNFi results in impaired vasodilator function and whether this relates to the development of a Disease Activity Score (DAS28)-based flare. Forty-one patients were assessed for eligibility as RA with at least 12 months of low disease activity (based on 28 joint counts); 35 enrolled into the randomised study: 8 were randomised to continue, 27 to stopping TNFi...
January 7, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29286840/effect-of-different-processing-methods-on-antihypertensive-property-and-antioxidant-activity-of-sandpaper-leaf-ficus-exasperata-extracts
#6
Odunayo Michael Agunloye, Ganiyu Oboh
Sandpaper leaf (Ficus exasperata) is commonly used in folk medicine to manage high blood pressure. However, different methods such as soaking, boiling, hand maceration, and blending have been employed for preparing sandpaper leaf extracts for hypertensive patients. This study sought to investigate and compare the influence of different processing methods on the antihypertensive properties of sandpaper leaf as well as its effect on Fe2+ and sodium nitroprusside- (SNP-) induced lipid peroxidation in rat heart in vitro...
December 29, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29286066/effects-of-erk1-2-s-nitrosylation-on-erk1-2-phosphorylation-and-cell-survival-in-glioma-cells
#7
Lei Jin, Yujia Cao, Tong Zhang, Peng Wang, Daofei Ji, Xuejiao Liu, Hengliang Shi, Lei Hua, Rutong Yu, Shangfeng Gao
Aberrant activation of extracellular signal‑regulated kinase 1/2 (ERK1/2) by phosphorylation modification can trigger tumor cell development in glioma. S‑nitrosylation, which refers to the covalent addition of a nitric oxide (NO) group to a cysteine (Cys) thiol, is an important post‑translational modification that occurs on numerous cancer‑associated proteins. Protein S‑nitrosylation can increase or decrease protein activity and stability, and subsequent signal transduction and cellular processes...
December 20, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29280941/superoxide-anions-and-no-in-the-paraventricular-nucleus-modulate-the-cardiac-sympathetic-afferent-reflex-in-obese-rats
#8
Qing-Bo Lu, Jing Sun, Ying Kang, Hai-Jian Sun, Hui-Shan Wang, Yuan Wang, Guo-Qing Zhu, Ye-Bo Zhou
This study was conducted to explore the hypothesis that the endogenous superoxide anions (O₂-) and nitric oxide (NO) system of the paraventricular nucleus (PVN) regulates the cardiac sympathetic afferent reflex (CSAR) contributing to sympathoexcitation in obese rats induced by a high-fat diet (42% kcal as fat) for 12 weeks. CSAR was evaluated by monitoring the changes of renal sympathetic nerve activity (RSNA) and the mean arterial pressure (MAP) responses to the epicardial application of capsaicin (CAP) in anaesthetized rats...
December 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29277696/oxidative-burst-activity-in-haemocytes-of-the-freshwater-prawn-macrobrachium-rosenbergii
#9
Jian-An Xian, Xiu-Xia Zhang, An-Li Wang, Jun-Tao Li, Pei-Hua Zheng, Yao-Peng Lu, Dong-Mei Wang, Jian-Min Ye
Oxidative burst, release of reactive oxygen species/reactive nitrogen species (ROS/RNS) contributed to microorganisms killing, is a vital immune response of crustacean haemocyte. Three morphologic haemocyte types (hyaline cells, HC; semigranular cells, SGC; granular cells, GC) have been defined in crustaceans, and found to play different roles in immune defense. However, oxidative burst activities of different haemocyte subpopulations in crustaceans are currently not documented. In the present study, we investigated the oxidative burst activities of the three haemocyte types in the freshwater prawn Macrobrachium rosenbergii using the common ROS fluorescent probe dichlorofluorescin-diacetate (DCFH-DA)...
December 22, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29277372/effects-of-chlorogenic-acid-on-carbachol-induced-contraction-of-mouse-urinary-bladder
#10
Takeharu Kaneda, Noriyasu Sasaki, Norimoto Urakawa, Kazumasa Shimizu
Chlorogenic acid (CGA) is a polyphenol found in coffee and medicinal herbs such as Lonicera japonica. In this study, the effect of CGA-induced relaxation on carbachol (CCh)-induced contraction of mouse urinary bladder was investigated. CGA (30-300 μg/ml) inhibited CCh- or U46619-induced contraction in a concentration-dependent manner. SQ22536 (adenylyl cyclase inhibitor) recovered CGA-induced relaxation of CCh-induced contraction; however, ODQ (guanylyl cyclase inhibitor) did not have the same effect. In addition, 3-isobutyl-1-methylxanthine (IBMX) enhanced CGA-induced relaxation; however, forskolin or sodium nitroprusside did not have the same effect...
December 15, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29276280/examining-the-use-of-sodium-nitroprusside-in-coronary-artery-bypass-grafting-is-the-benefit-worth-the-cost
#11
Caitlin M Gibson, Sondra Davis, Darien Bradford
Purpose: Sodium nitroprusside is a vasodilator frequently used in the coronary artery bypass grafting (CABG) setting. However, the price of a 50-mg vial of sodium nitroprusside increased from $5.00 in 2003 to up to $900 in 2016. The purpose of this review is to help health systems balance high-quality patient care with economic responsibility. Methods: A MEDLINE literature search was performed using the search terms "nitroprusside" and "coronary artery bypass." All English-language trials in human subjects assessing the use of sodium nitroprusside in the setting of CABG were evaluated...
July 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29273789/widespread-coronary-dysfunction-in-the-absence-of-hdl-receptor-sr-b1-in-an-ischemic-cardiomyopathy-mouse-model
#12
James T Pearson, Misa Yoshimoto, Yi Ching Chen, Rohullah Sultani, Amanda J Edgley, Hajime Nakaoka, Makoto Nishida, Keiji Umetani, Mark T Waddingham, Hui-Ling Jin, Yuan Zhang, Darren J Kelly, Daryl O Schwenke, Tadakatsu Inagaki, Hirotsugu Tsuchimochi, Issei Komuro, Shizuya Yamashita, Mikiyasu Shirai
Reduced clearance of lipoproteins by HDL scavenger receptor class B1 (SR-B1) plays an important role in occlusive coronary artery disease. However, it is not clear how much microvascular dysfunction contributes to ischemic cardiomyopathy. Our aim was to determine the distribution of vascular dysfunction in vivo in the coronary circulation of male mice after brief exposure to Paigen high fat diet, and whether this vasomotor dysfunction involved nitric oxide (NO) and or endothelium derived hyperpolarization factors (EDHF)...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29251668/perioperative-fluid-accumulation-impairs-intestinal-contractility-to-a-smilar-extent-as-peritonitis-and-endotoxemia
#13
José Gorrasi, Stephan M Jakob, Luis Tovar, Bruno Balsiger, Sebastian Brandt, Lukas E Bruegger, Hendrik Bracht, Jukka Takala
BACKGROUND: Perioperative resuscitation with large amounts of fluid may cause tissue edema, especially in the gut, and thereby impair its functions. This is especially relevant in sepsis where capillaries become leaky and fluid rapidly escapes to the pericapillary tissue. We assessed the effects of endotoxemia and peritonitis, and the use of high and moderate volume fluid resuscitation on jejunal contractility. We hypothesized that both endotoxemia and peritonitis impair jejunum contractility and relaxation, and that this effect is aggravated in peritonitis and with high fluid administration...
December 14, 2017: Shock
https://www.readbyqxmd.com/read/29248109/venous-stent-placement-ameliorates-cutaneous-microvascular-function-in-iliocaval-venous-obstruction
#14
Cüneyt Köksoy, Muzaffer Akkoca, Serhat Tokgöz, Arda Çetinkaya, Yusuf Sevim, Emine Demirel-Yılmaz
BACKGROUND: The role of cutaneous microvascular dysfunction is well known in the development of chronic venous disease. However, the effects of venous obstruction on microcirculation have not been well investigated. The aim of this study was to assess cutaneous microvascular function in patients with iliocaval venous obstruction (ICVO) before and after venous stent placement. METHODS: Endothelium-dependent and endothelium-independent vasodilator responses to iontophoretic administration of incremental doses of acetylcholine (ACh) and sodium nitroprusside (SNP) were evaluated using a laser Doppler scanner in the perimalleolar region in the supine and sitting positions in patients with ICVO (n = 11) and in healthy control subjects (n = 15)...
January 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29247650/increased-circulating-trimethylamine-n-oxide-contributes-to-endothelial-dysfunction-in-a-rat-model-of-chronic-kidney-disease
#15
Tiejun Li, Chaojun Gua, Baogang Wu, Yanli Chen
Chronic kidney disease (CKD) is strongly associated with increased cardiovascular risk. Impaired endothelial function, a key initiating step in the pathogenesis of cardiovascular disease, has been reported in patients with CKD, but the mechanisms responsible for endothelial dysfunction in CKD remain elusive. Emerging evidence reveals that trimethylamine-N-oxide (TMAO), a gut microbiota-generated metabolite, is involved in the pathogenesis of many cardiovascular diseases. Circulating TMAO is elevated in CKD...
December 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29235883/nitric-oxide-modulates-the-responses-of-osteoclast-formation-to-static-magnetic-fields
#16
Jian Zhang, Chong Ding, Xiaofeng Meng, Peng Shang
Nitric oxide (NO) is involved in osteoclast differentiation. Our previous studies showed that static magnetic fields (SMFs) could affect osteoclast differentiation. The inhibitory effects of 16 T of high SMF (HiMF) on osteoclast differentiation was correlated with increased production of NO. We raised the hypothesis that NO mediated the regulatory role of SMFs on osteoclast formation. In this study, 500 nT of hypomagnetic field (HyMF), 0.2 T of moderate SMF (MMF) and 16 T of high SMF (HiMF) were utilized as SMF treatment...
December 13, 2017: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/29234346/involvement-of-sodium-nitroprusside-snp-in-the-mechanism-that-delays-stem-bending-of-different-gerbera-cultivars
#17
Aung H Naing, Kyoungsun Lee, Kyoung-Ook Kim, Trinh N Ai, Chang K Kim
Longevity of cut flowers of many gerbera cultivars (Gerbera jamesonii) is typically short because of stem bending; hence, stem bending that occurs during the early vase life period is a major problem in gerbera. Here, we investigated the effects of sodium nitroprusside (SNP) on the delay of stem bending in the gerbera cultivars, Alliance, Rosalin, and Bintang, by examining relative fresh weight, bacterial density in the vase solution, transcriptional analysis of a lignin biosynthesis gene, antioxidant activity, and xylem blockage...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29234180/role-of-the-nitrergic-system-of-the-cuneiform-nucleus-in-cardiovascular-responses-in-urethane-anesthetized-male-rats
#18
Esmaeil Farrokhi, Mohammad Naser Shafei, Abolfazl Khajavirad, Mahmoud Hosseini, Ali Reza Ebrahimzadeh Bideskan
Background: The presence of nitric oxide (NO) in the cuneiform nucleus (CnF) has been previously shown. In this study, NG-nitro-L-arginine methyl ester (L-NAME) (an inhibitor of NO synthase), L-arginine (L-Arg) (a precursor of NO), and sodium nitroprusside (SNP) (a donor of NO) were microinjected into the CnF and cardiovascular responses were investigated. Methods: Seventy male rats were divided into 7 groups (n=10 each): 1) saline, 2 and 3) L-NAME (30 and 90 nmol), 4 and 5) L-Arg (20 and 60 nmol), and 6 and 7) SNP (9 and 27 nmol)...
September 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29212831/impaired-pulmonary-arterial-vasoconstriction-and-nitric-oxide-mediated-relaxation-underlie-severe-pulmonary-hypertension-in-sugen-hypoxia-rat-model
#19
Helen Christou, Hannes Hudalla, Zoe Michael, Evgenia Filatava, Jun Li, Minglin Zhu, Jose Possomato-Vieira, Carlos Dias-Junior, Stella Kourembanas, Raouf A Khalil
Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and examined the underlying mechanisms, in the sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with sugen (20 mg/kg sc) and exposed to hypoxia (9% O2) for 3 weeks followed by 4 weeks in normoxia (Su/Hx), or treated with sugen alone (Su) or hypoxia alone (Hx) or neither (Nx). After hemodynamic measurements, the heart was assessed for right ventricular hypertrophy (Fulton's Index), the pulmonary artery, aorta and mesenteric arteries were isolated for vascular function studies, and contractile markers were measured in pulmonary artery using quantitative PCR...
December 6, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29210478/type-2-diabetes-specifically-attenuates-purinergic-skin-vasodilatation-without-affecting-muscarinic-and-nicotinic-skin-vasodilatation-and-sweating
#20
Naoto Fujii, Robert D Meade, Brendan D McNeely, Takeshi Nishiyasu, Ronald J Sigal, Glen P Kenny
The present study evaluated whether type 2 diabetes (T2D) attenuates muscarinic and/or nicotinic cutaneous vasodilatation and sweating as well as purinergic cutaneous vasodilatation. Cutaneous vascular conductance and sweat rate were evaluated in 12 healthy nondiabetic older adults (Control, 60 ± 8 years) and 13 older adults with T2D (62 ± 10 years) at three intradermal forearm skin sites perfused with the following: 1) methacholine (muscarinic receptor agonist, 5 doses: 0.0125, 0.25, 5, 100, 2000 mm), 2) nicotine (nicotinic receptor agonist, 5 doses: 1...
December 6, 2017: Experimental Physiology
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