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Sodium nitroprusside

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https://www.readbyqxmd.com/read/28912956/cardiometabolic-effects-of-a-novel-sirt1-activator-srt2104-in-people-with-type-2-diabetes-mellitus
#1
Radzi M Noh, Sowmya Venkatasubramanian, Shruti Daga, Jeremy Langrish, Nicholas L Mills, Ninian N Lang, Ethan Hoffmann, Brian Waterhouse, David E Newby, Brian M Frier
BACKGROUND: The cardiometabolic effects of SRT2104, a novel SIRT1 activator, were investigated in people with type 2 diabetes mellitus (T2DM). METHODS: Fifteen adults with T2DM underwent a randomised, double-blind, placebo-controlled cross-over trial and received 28 days of oral SRT2104 (2.0 g/day) or placebo. Forearm vasodilatation (measured during intrabrachial bradykinin, acetylcholine and sodium nitroprusside infusions) as well as markers of glycaemic control, lipid profile, plasma fibrinolytic factors, and markers of platelet-monocyte activation, were measured at baseline and at the end of each treatment period...
2017: Open Heart
https://www.readbyqxmd.com/read/28912106/vascular-activation-of-k-channels-and-na-k-atpase-activity-of-estrogen-deficient-female-rats
#2
Rogério Faustino Ribeiro, Jonaina Fiorim, Vinicius Bermond Marques, Karoline de Sousa Ronconi, Tatiani Botelho, Marcella D Grando, Lusiane M Bendhack, Dalton Valentim Vassallo, Ivanita Stefanon
The goal of the present study was to evaluate vascular potassium channels and Na(+)-K(+)-ATPase activity in estrogen deficient female rats. Female rats that underwent ovariectomy were assigned to receive daily treatment with placebo (OVX) or estrogen replacement (OVX+E2, 1mg/kg, once a week, i.m.). Aortic rings were used to examine the involvement of K(+) channels and Na(+)-K(+)-ATPase in vascular reactivity. Acetylcholine (ACh)-induced relaxation was analyzed in the presence of L-NAME (100μM) and K(+) channels blockers: tetraethylammonium (TEA, 5mM), 4-aminopyridine (4-AP, 5mM), iberiotoxin (IbTX, 30nM), apamin (0...
September 11, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28900851/tributyltin-chloride-disrupts-aortic-vascular-reactivity-and-increases-reactive-oxygen-species-production-in-female-rats
#3
Carolina Falcão Ximenes, Samya Mere Lima Rodrigues, Priscila Lang Podratz, Eduardo Merlo, Julia Fernandez Puñal de Araújo, Lívia Carla Melo Rodrigues, Juliana Barbosa Coitinho, Dalton Valentim Vassallo, Jones Bernardes Graceli, Ivanita Stefanon
Organotin compounds, such as tributyltin (TBT), are environment contaminants that induce bioaccumulation and have potential toxic effects on marine species and mammals. TBT have been banned by the International Maritime Organization in 2003. However, the assessment of butyltin and metal contents in marine sediments has demonstrated high residual levels of TBT in some cases exceeding 7000 ng Sn g(-1). The acceptable daily intake (ADI) level for TBT established by the World Health Organization is 0.5 μg/kg bw/day is based on genotoxicity, reproduction, teratogenicity, immunotoxicity, and mainly neurotoxicity...
September 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28894506/a-cystine-rich-whey-supplement-immunocal%C3%A2-provides-neuroprotection-from-diverse-oxidative-stress-inducing-agents-in-vitro-by-preserving-cellular-glutathione
#4
Aimee N Winter, Erika K Ross, Vamsi Daliparthi, Whitney A Sumner, Danielle M Kirchhof, Evan Manning, Heather M Wilkins, Daniel A Linseman
Oxidative stress is a principal mechanism underlying the pathophysiology of neurodegeneration. Therefore, nutritional enhancement of endogenous antioxidant defenses may represent a viable treatment option. We investigated the neuroprotective properties of a unique whey protein supplement (Immunocal®) that provides an essential precursor (cystine) for synthesis of the endogenous antioxidant, glutathione (GSH). Primary cultures of rat cerebellar granule neurons (CGNs), NSC34 motor neuronal cells, or HT22 hippocampal cells were preincubated in medium containing Immunocal and then subsequently treated with agents known to induce oxidative stress...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28892640/beneficial-effects-of-rosiglitazone-and-losartan-combination-in-diabetic-rats
#5
Hayam Ateyya, Manar Nader, Nagla Ahmad El-Sherbeeny
Diabetes with vascular complication needs strict interventions to retard possible serious complications. This research estimated the possible interaction of rosiglitazone (RGN) with losartan (Los) in diabetic rats. Male Spraque Dawly rats were randomly divided into: non-diabetic rats, diabetic rats, and diabetic rats received RGN, Los or combination of RGN and Los. Measurement of serum glucose, vascular adhesion molecule-1 (VCAM-1), interleukin (IL)-6, tumor necrosis factor and (TNF)-α levels, and aortic lipid peroxide (MDA), glutathione (GSH), superoxide dismutase (SOD) and total nitrate/nitrite (NOx) levels were done...
September 11, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28891586/poly-n-acryloyl-l-phenylalanine-methyl-ester-hollow-core-nanocapsules-facilitate-sustained-delivery-of-immunomodulatory-drugs-and-exhibit-adjuvant-properties
#6
Anil Kumar Yamala, Vinod Nadella, Yitzhak Mastai, Hridayesh Prakash, Pradip Paik
Polymeric hollow nanocapsules have attracted significant research attention as novel drug carriers and their preparation is of particular concern owing to the feasibility to encapsulate a broad range of drug molecules. This work presents for the first time the synthesis and development of novel poly-N-acryloyl l-phenylalanine methyl ester hollow core nanocapsules (NAPA-HPNs) of avg. size ca. 100-150 nm by the mini-emulsion technique. NAPA-HPNs are biocompatible and capable of encapsulating sodium nitroprusside (SNP) at a rate of ∼1...
September 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28882231/hemodynamic-response-to-nitroprusside-in-patients-with-low-gradient-severe-aortic-stenosis-and-preserved-ejection-fraction
#7
James W Lloyd, Rick A Nishimura, Barry A Borlaug, Mackram F Eleid
BACKGROUND: Low-gradient severe aortic stenosis (LGSAS) with preserved ejection fraction (EF) is incompletely understood. The influence of arterial afterload and diastolic dysfunction on the hemodynamic presentation of LGSAS remains unknown. OBJECTIVES: The authors sought to determine the acute hemodynamic response to sodium nitroprusside in LGSAS with preserved EF. METHODS: Symptomatic patients with LGSAS and preserved EF underwent cardiac catheterization with comparison of hemodynamic measurements before and after nitroprusside...
September 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28879572/diligustilide-releases-h2s-and-stabilizes-s-nitrosothiols-in-ethanol-induced-lesions-on-rat-gastric-mucosa
#8
Josué Arturo Velázquez-Moyado, José Luis Balderas-López, Elizabeth Arlen Pineda-Peña, Brenda Lorena Sánchez-Ortiz, José Carlos Tavares-Carvalho, Andrés Navarrete
(Z,Z')-Diligustilide (DLG) or levistolide A is a dimeric phthalide isolated from Ligusticum porteri (Osha), the roots of which are used in the traditional treatment of many diseases including gastric aches. However, its action has not been completely elucidated. We analyzed the contributions of hydrogen sulfide and S-nitrosothiols to the action of DLG. Animals were pretreated with freshly formed in vitro nitrosothiol using Na2S and sodium nitroprusside to elucidate participation in the action of DLG. We also evaluated the production of H2S in vivo and in real time on the stomach via a specific electrode introduced into the stomachs of anaesthetized animals pretreated with DLG...
September 6, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28875100/development-of-an-advanced-diagnostic-concept-for-intestinal-inflammation-molecular-visualisation-of-nitric-oxide-in-macrophages-by-functional-poly-lactic-co-glycolic-acid-microspheres
#9
Kathleen Lange, Christian Lautenschläger, Maria Wallert, Stefan Lorkowski, Andreas Stallmach, Alexander Schiller
We here describe a new approach to visualise nitric oxide (NO) in living macrophages by fluorescent NO-sensitive microspheres based on poly(lactic-co-glycolic acid) (PLGA). PLGA microspheres loaded with NO550 dye were prepared through a modified solvent-evaporation method. Microparticles were characterized by a mean hydrodynamic diameter of 3000 nm, zeta potential of -26.000 ± 0.351 mV and a PDI of 0.828 ± 0.298. Under abiotic conditions, NO release was triggered through UV radiation (254 nm) of 10 mM sodium nitroprusside dehydrate (SNP)...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28874121/characterization-of-the-role-of-sodium-nitroprusside-snp-involved-in-long-vase-life-of-different-carnation-cultivars
#10
Aung Htay Naing, Kyoungsun Lee, Muthukrishnan Arun, Ki Byung Lim, Chang Kil Kim
BACKGROUND: Sodium nitroprusside (SNP) has been previously shown to extend the vase life of various cut flowers; however, its positive effect on extending vase life of carnations has not been well documented. Moreover, the role of SNP in the mechanisms underlying determination of vase life of cut carnations has also not been well addressed. RESULTS: SNP increased vase life of Tico Viola carnations along with their relative fresh weight (RFW). Among the treatments, the flowers treated with 10 mg L(-1) SNP had the longest vase life and maximum relative fresh weight (RFW)...
September 6, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28870522/poly-i-c-impairs-no-donor-induced-relaxation-by-overexposure-to-no-via-the-nf-kappa-b-inos-pathway-in-rat-superior-mesenteric-arteries
#11
Makoto Ando, Takayuki Matsumoto, Kumiko Taguchi, Tsuneo Kobayashi
Recent studies have suggested a link between vascular dysfunction and innate immune activation including toll-like receptors (TLRs), but the detailed mechanism remains unclear. Here we investigated whether poly (I:C) [a synthetic double-strand RNA recognized by TLR3, melanoma differentiation-associated gene 5 (MDA5), and retinoic acid-inducible gene I (RIG-I)] affected nitric oxide (NO)/cGMP-related vascular relaxation, one of the major cascades of relaxation, in rat superior mesenteric arteries. Using organ-cultured arteries, we found that poly (I:C) (30μg/mL for approximately 1 day) markedly reduced sodium nitroprusside (SNP)-induced relaxation (vs...
September 1, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28862537/signaling-through-reactive-oxygen-and-nitrogen-species-is-differentially-modulated-in-sunflower-seedling-root-and-cotyledon-in-response-to-various-nitric-oxide-donors-and-scavengers
#12
Neha Singh, Satish C Bhatla
Sodium nitroprusside (SNP), diethylenetriamine NONOate (DETA), S-nitroso-n-acetyl-D,L- penicillamine (SNAP), and 4-(p-methoxyphenyl)-1,3,2- Oxathiazolylium-5-olate (CAY) exhibit differential NO releasing ability in aqueous solution and hemoglobin is a more efficient NO quencher than cPTIO in solution. DETA releases 16% more NO compared with SNP in solution. Various NO donors (SNP, DETA, SNAP, and CAY) also bring about a differential but concentration-dependent increase in endogenous NO in seedling cotyledons and roots...
September 1, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28860170/effects-of-vehicle-microdialysis-solutions-on-cutaneous-vascular-responses-to-local-heating
#13
Caroline J Smith, Daniel H Craighead, Lacy M Alexander
Microdialysis is a minimally invasive technique often paired with laser Doppler flowmetry to examine cutaneous microvascular function, yet presents with several challenges, including incompatibility with perfusion of highly lipophilic compounds. The present study addresses this methodological concern, with an emphasis on the independent effects of commonly used vehicle dialysis solutions to improve solubility of pharmacological agents with otherwise low aqueous solubility. Four microdialysis fibers were placed in the ventral forearm of eight subjects (4 men, 4 women; 25 ± 1 years) with sites randomized to serve as 1) control (lactated Ringer's), 2) Sodium carbonate-bicarbonate buffer administered at physiological pH (SCB-HCL; pH 7...
August 31, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28852442/cardiovascular-effects-of-nitrergic-system-of-the-pedunculopontine-tegmental-nucleus-in-anesthetized-rats
#14
Mohammad Naser Shafei, Tahereh Nikyar, Mahmoud Hosseini, Saeed Niazmand, Maryam Paseban
OBJECTIVES: Nitric oxide (NO) is an important neurotransmitter in central nervous system involved in central cardiovascular regulation. The presence of NO in the pedunculopontine tegmental (PPT) nucleus has been shown, but its cardiovascular effect has not been determined. In the present study, the cardiovascular effect of NO in the PPT nucleus was evaluated. MATERIALS AND METHODS: After induction of anesthesia, a polyethylene catheter (PE-50) filled with heparinized saline inserted into the femoral artery, and the blood pressure (BP) and heart rate (HR) were continuously recorded...
July 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28846879/insufficient-sleep-is-associated-with-impaired-nitric-oxide-mediated-endothelium-dependent-vasodilation
#15
Anthony R Bain, Brian R Weil, Kyle J Diehl, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza
BACKGROUND AND AIMS: Habitual short nightly sleep duration is associated with increased atherosclerotic cardiovascular disease risk and morbidity. Vascular endothelial dysfunction represents an important mechanism that may underlie this heightened cardiovascular risk. Impaired endothelium-dependent vasodilation, particularly NO-mediated vasodilation, contributes to the development and progression of atherosclerotic vascular disease and acute vascular events. We tested the hypothesis that chronic insufficient sleep is associated with impaired NO-mediated endothelium-dependent vasodilation in middle-aged adults...
August 18, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28843888/seed-priming-by-sodium-nitroprusside-improves-salt-tolerance-in-wheat-triticum-aestivum-l-by-enhancing-physiological-and-biochemical-parameters
#16
Qasim Ali, M K Daud, Muhammad Zulqurnain Haider, Shafaqat Ali, Muhammad Rizwan, Nosheen Aslam, Ali Noman, Naeem Iqbal, Faisal Shahzad, Farah Deeba, Iftikhar Ali, Shui Jin Zhu
The germination, seedling vigor, crop establishment and yield of agronomically important crops is negatively affected by soil salinity. The current study aimed to investigate the ability of exogenous fertigation by sodium nitroprusside (SNP) to induce salt tolerance in four high yielding wheat cultivars (Sahar-06, Punjab-11, Millat-11 and Galaxy-13) that differ in their response to salt stress in terms of biomass production, oxidative defense mechanisms and grain yield. Three levels of SNP (0, 0.1 and 0.2 mM) were used for seed soaking...
August 18, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28842684/plasmodium-falciparum-gpcr-like-receptor-sr25-mediates-extracellular-k-sensing-coupled-to-ca-2-signaling-and-stress-survival
#17
Miriam S Moraes, Alexandre Budu, Maneesh K Singh, Lucas Borges-Pereira, Julio Levano-Garcia, Chiara Currà, Leonardo Picci, Tomasino Pace, Marta Ponzi, Tullio Pozzan, Célia R S Garcia
The malaria parasite Plasmodium falciparum is exposed, during its development, to major changes of ionic composition in its surrounding medium. We demonstrate that the P. falciparum serpentine-like receptor PfSR25 is a monovalent cation sensor capable of modulating Ca(2+) signaling in the parasites. Changing from high (140 mM) to low (5.4 mM) KCl concentration triggers [Ca(2+)]cyt increase in isolated parasites and this Ca(2+) rise is blocked either by phospholipase C (PLC) inhibition or by depleting the parasite's internal Ca(2+) pools...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28837867/the-inhibition-of-inducible-nitric-oxide-synthase-and-oxidative-stress-by-agmatine-attenuates-vascular-dysfunction-in-rat-acute-endotoxemic-model
#18
Mohammed S El-Awady, Manar A Nader, Maha H Sharawy
Vascular dysfunction leading to hypotension is a major complication in patients with septic shock. Inducible nitric oxide synthase (iNOS) together with oxidative stress play an important role in development of vascular dysfunction in sepsis. Searching for an endogenous, safe and yet effective remedy was the chief goal for this study. The current study investigated the effect of agmatine (AGM), an endogenous metabolite of l-arginine, on sepsis-induced vascular dysfunction induced by lipopolysaccharides (LPS) in rats...
August 16, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28836406/subcellular-distribution-of-s-nitrosylated-h-ras-in-differentiated-and-undifferentiated-pc12-cells-during-hypoxia
#19
Tamar Barbakadze, Galina Goloshvili, Nana Narmania, Elene Zhuravliova, David Mikeladze
OBJECTIVES: Hypoxia or exposure to excessive reactive oxygen or nitrogen species could induce S-nitrosylation of various target proteins, including GTPases of the Ras-superfamily. Under hypoxic conditions, the Ras-protein is translocated to the cytosol and interacts with the Golgi complex, endoplasmic reticulum, mitochondria. The mobility/translocation of Ras depend on the cells oxidative status. However, the importance of relocated Snitrosylated- H-Ras (NO-H-Ras) in proliferation/differentiation processes is not completely understood...
October 2017: Cell Journal
https://www.readbyqxmd.com/read/28836059/posterior-reversible-encephalopathy-syndrome-in-children-with-kidney-disease
#20
REVIEW
Cristina Gavrilovici, Ingrith Miron, Luminiţa Voroneanu, Silvia Bădărau, Magdalena Stârcea
Posterior reversible encephalopathy syndrome (PRES) has been described as a neurological condition observed in a variety of clinical settings and is characterized by focal neurological deficits, seizures, headaches, altered mental status, and visual impairment, associated with transient typical lesions on neuroimaging, predominantly in the posterior part of the brain. The most common risk factors for PRES are hypertension, renal diseases, and the use of calcineurin inhibitors. The incidence of PRES in children with renal disorders varies between 4 and 9%, according to different reports...
August 23, 2017: International Urology and Nephrology
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