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https://www.readbyqxmd.com/read/29031209/relative-value-of-three-whole-body-mr-approaches-for-pet-mr-including-gadofosveset-enhanced-mr-in-comparison-to-pet-ct
#1
Piotr Obara, Andreas Loening, Valentina Taviani, Andrei Iagaru, Brian A Hargreaves, Shreyas Vasanawala
PURPOSE: Evaluate MR protocol for PET-MR including coronal DWI (cDWI), fat-suppressed T2 (T2w), and gadofosveset-enhanced T1 (CE). MATERIALS AND METHODS: 18 patients underwent same-day PET-CT and PET-MR. Image quality and performance of each sequence, and combination of all three sequences, was evaluated with respect to PET-CT. RESULTS: Lesion conspicuity was best on cDWI, while delineation was best on CE. Considering all three sequences combined, both readers showed good sensitivity and specificity (>80%)...
September 29, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29028830/er-stress-and-subsequent-activated-calpain-play-a-pivotal-role-in-skeletal-muscle-wasting-after-severe-burn-injury
#2
Li Ma, Wanli Chu, Jiake Chai, Chuanan Shen, Dawei Li, Xiaoteng Wang
Severe burns are typically followed by hypermetabolism characterized by significant muscle wasting, which causes considerable morbidity and mortality. The aim of the present study was to explore the underlying mechanisms of skeletal muscle damage/wasting post-burn. Rats were randomized to the sham, sham+4-phenylbutyrate (4-PBA, a pharmacological chaperone promoting endoplasmic reticulum (ER) folding/trafficking, commonly considered as an inhibitor of ER), burn (30% total body surface area), and burn+4-PBA groups; and sacrificed at 1, 4, 7, 14 days after the burn injury...
2017: PloS One
https://www.readbyqxmd.com/read/29028790/imaging-factors-that-distinguish-between-patients-with-asymptomatic-and-symptomatic-cervical-spondylotic-myelopathy-with-mild-to-moderate-cervical-spinal-cord-compression
#3
Jun Ming Cao, Jing Tao Zhang, Da Long Yang, Yi Peng Yang, He Huan Xia, Liu Yang
BACKGROUND Not all patients with spinal cord compression due to cervical spondylotic myelopathy (CSM) have clinical symptoms and signs. The aim of this study was to investigate and compare the imaging findings in asymptomatic and symptomatic patients with CSM with mild to moderate cervical spinal cord compression. MATERIAL AND METHODS A retrospective clinical study included 68 patients. Group A (n=30) had no symptoms and signs; group B (n=38) had symptoms and signs of cervical myelopathy. The age, sex, body mass index (BMI), history of steroid treatment, duration of symptoms, number of spondylotic cervical segments, Torg ratio, range of motion (ROM), incidence of cervical segmental instability, overall curvature of the cervical spine, direction of spinal cord compression, and spinal cord magnetic resonance imaging (MRI) signal intensity were compared...
October 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29027724/adsorbed-eutectic-gain-structures-on-a-neoprene-foam-for-stretchable-mri-coils
#4
Matija Varga, Andreas Mehmann, Josip Marjanovic, Jonas Reber, Christian Vogt, Klaas Paul Pruessmann, Gerhard Tröster
Stretchable conductors based on eutectic gallium-indium (eGaIn) alloy are patterned on a polychloroprene substrate (neoprene foam) using stencil printing. By tuning the amount of eGaIn on the neoprene substrate, different strain-sensitivity of electrical resistance is achieved. Conductors with a layer of eGaIn, which adsorbs to the walls of 60-100 µm wide neoprene cells, change their electrical resistance for 5% at 100% strain. When the amount of eGaIn is increased, the cells are filled with eGaIn and the strain-sensitivity of the electrical resistance rises to 300% at 100% strain...
October 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29027115/correlation-between-mri-and-hip-arthroscopy-in-children-with-legg-calve-perthes-disease
#5
V Tiwari, S Gamanagatti, R Mittal, H Nag, S A Khan
BACKGROUND: Most of the information available about Legg-Calve-Perthes disease (LCPD) at present is gained through imaging modalities including plain radiographs and magnetic resonance imaging (MRI). But the accuracy of MRI in this disease and its predictive value to reveal various intra-articular pathologies is not known. We correlated the findings of MRI with those seen on hip arthroscopy in children with active stage of LCPD. METHODS: We conducted a prospective observational study in which MRI findings were correlated with corresponding findings on hip arthroscopy in a cohort of 25 patients of active LCPD below 12 years of age...
October 12, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29027087/the-effect-of-using-a-dielectric-matching-medium-in-focused-microwave-radiometry-an-anatomically-detailed-head-model-study
#6
Maria Koutsoupidou, Evangelos Groumpas, Irene S Karanasiou, Maria Christopoulou, Konstantina Nikita, Nikolaos Uzunoglu
Microwave radiometry is a passive technique used to measure in-depth temperature distributions inside the human body, potentially useful in clinical applications. Experimental data imply that it may provide the capability of detecting in-depth local variations of temperature and/or conductivity of excitable tissues at microwave frequencies. Specifically, microwave radiometry may allow the real-time monitoring of brain temperature and/or conductivity changes, associated with local brain activation. In this paper, recent results of our ongoing research regarding the capabilities of focused microwave radiometry for brain intracranial applications are presented...
October 13, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29026931/imaging-patterns-of-rhino-orbital-cerebral-mucormycosis-in-immunocompromised-patients-when-to-suspect-complicated-mucormycosis
#7
Peter Raab, Ludwig Sedlacek, Stefanie Buchholz, Stefan Stolle, H Lanfermann
PURPOSE: The aim of this study was to describe radiological imaging findings of a complicated sinusitis, which should raise the suspicion of rhino-orbital-cerebral mucormycosis as being the underlying cause. METHODS: In this retrospective analysis, we describe the cases and imaging findings of 8 patients with proven mucormycosis. These patients presented mostly with new facial or orbital swelling and were referred for imaging to our institution. Magnetic resonance imaging and computed tomography images were classified as abnormal or normal with respect to orbital, paranasal and cerebral signal results...
October 12, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29026161/in-vivo-noninvasive-microscopy-of-human-leucocytes
#8
Matan M Winer, Adel Zeidan, Daniella Yeheskely-Hayon, Lior Golan, Limor Minai, Eldad J Dann, Dvir Yelin
Leucocytes play a key role in our immune system, protecting the body against infections using a wide range of biological mechanisms. Effective imaging and identification of leucocytes within the blood stream in patients is challenging, however, because of their low volume fraction in the blood, the high tissue scattering and the rapid blood flow. Spectrally encoded flow cytometry (SEFC) has recently been demonstrated effective for label-free high-resolution in vivo imaging of blood cells using an optical probe that does not require mechanical scanning...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025985/safety-biodistribution-and-radiation-dosimetry-of-68-ga-ops202-68-ga-nodaga-jr11-in-patients-with-gastroenteropancreatic-neuroendocrine-tumors-a-prospective-phase-i-imaging-study
#9
Guillaume P Nicolas, Seval Beykan, Hakim Bouterfa, Jens Kaufmann, Andreas Bauman, Michael Lassmann, Jean Claude Reubi, Jean E F Rivier, Helmut R Maecke, Melpomeni Fani, Damian Wild
Preclinical and preliminary clinical evidence indicates that radiolabeled somatostatin receptor (sst) antagonists perform better than agonists in terms of detecting neuroendocrine tumors (NETs). This prospective phase I/II study is the first to evaluate an sst antagonist, (68)Ga-OPS202 ((68)Ga-NODAGA-JR11; NODAGA=1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid and JR11=Cpa-c(DCys-Aph(Hor)-DAph(Cbm)-Lys-Thr-Cys)-DTyr-NH2)) for PET imaging. Here, we report results of the phase I component of the study...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29025206/nonalcoholic-fatty-liver-disease-in-long-term-survivors-of-childhood-onset-craniopharyngioma
#10
So Yoon Jung, Yun Jeong Lee, Hye Jin Lee, Young Ah Lee, Jin Soo Moon, Jae Sung Ko, Sei Won Yang, Choong Ho Shin
PURPOSE: Hypothalamic obesity in childhood-onset (CO-) craniopharyngioma patients may predispose to nonalcoholic fatty liver disease (NAFLD). This study reviewed the characteristics of NAFLD associated with CO-craniopharyngioma. METHODS: This study retrospectively reviewed 75 patients who underwent surgery for craniopharyngioma while younger than 15 years of age between 2000 and 2016. RESULTS: Elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) above 40 IU/L was observed in 51 of the 75 (68%) CO-craniopharyngioma patients...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29024961/epidural-fat-and-its-association-with-pain-physical-function-and-disability-among-older-adults-with-low-back-pain-and-controls
#11
Jaclyn Megan Sions, Christina Angelica Rodriguez, Ryan Todd Pohlig, Gregory Evan Hicks, Peter Charles Coyle
Objective: To examine epidural fat and its relationship to pain, physical function, and disability among older adults with chronic low back pain, chronic low back pain plus leg pain, and controls. Design: Cross-sectional, comparative study. Setting: Standardized examinations were conducted in a research laboratory, and magnetic resonance images were obtained. Subjects: A total of 93 adults age 60 to 85 years (24 with chronic back pain, 25 with chronic back pain plus leg pain, and 44 controls)...
September 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29024836/performance-of-a-simple-robust-empiric-timing-protocol-for-ct-pulmonary-angiography
#12
Kevin A Hsu, Jeffrey M Levsky, Linda B Haramati, Arash Gohari
OBJECTIVE: We instituted a new, simple CT pulmonary angiography (CTPA) contrast material timing protocol using a standard empiric delay to replace our previous timing bolus method. This study tests the hypothesis that the empiric protocol more consistently produces diagnostic quality images of both the pulmonary arteries and the aorta with lower radiation exposure. MATERIALS AND METHODS: We performed a retrospective review of consecutive CTPAs for 2months both before and after the protocol change...
September 14, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29024791/imaging-microstructure-in-the-living-human-brain-a-viewpoint
#13
REVIEW
Tomáš Paus
This special issue summarizes an impressive body of work concerned with in vivo imaging of brain microstructure. Collectively, papers included here demonstrate the power of multi-modal magnetic resonance imaging (MRI) for mapping various structural properties of brain tissue. In this introduction, I provide a user's perspective vis-à-vis motivations for these efforts, review briefly the cellular composition of grey and white matter in the human brain, and provide a few examples of how we can bridge the gap between ex vivo and in vivo datasets to facilitate interpretation of studies measuring brain macro- and microstructure...
October 9, 2017: NeuroImage
https://www.readbyqxmd.com/read/29024597/significant-chondrocyte-viability-is-present-in-acetabular-chondral-flaps-associated-with-femoroacetabular-impingement
#14
Vonda J Wright, Christopher Laurence McCrum, Hongshuai Li, Michael J Tranovich, Johnny Huard
BACKGROUND: Patients presenting with cam deformity of the femoral head and neck sustain repeated trauma to the articular cartilage of the superior acetabulum, with chondral delamination injuries found during hip arthroscopy. Two previous studies reveal conflicting chondrocyte viability data in these traumatic cartilage injuries. The full-thickness nature of flaps may suggest that chondrocytes residing in the cartilage flap matrix in the joint environment would remain viable despite shear trauma...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29024572/radiological-manifestations-of-immune-related-adverse-effects-observed-in-patients-with-melanoma-undergoing-immunotherapy
#15
Parveen Sidhu, Alexander M Menzies, Georgina Long, Matteo Carlino, Shirleen Lorens, Rony Kapoor
Immunotherapy drugs work by stimulating the patient's own immune system to recognize and destroy cancer cells. This subclass of drugs is increasingly administered to patients with advanced melanoma. They are also commonly incorporated into other cancer therapies such as non-small cell lung cancer, renal cancer, head and neck cancers and Hodgkin lymphoma. The most commonly administered immunotherapeutic agents in the treatment of melanoma include programmed cell death protein 1 (PD-1) inhibitors, cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitors and a subclass of cytokines...
October 11, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29024413/deep-tissue-loads-in-the-seated-buttocks-on-an-off-loading-wheelchair-cushion-versus-air-cell-based-and-foam-cushions-finite-element-studies
#16
Lea Peko Cohen, Amit Gefen
For wheelchair users, a common injury is a sitting-acquired pressure ulcer (PU) which typically onsets near the interface between the ischial tuberosity (IT) and the overlying soft tissues. The risk of developing PUs can be reduced considerably if an adequate cushion is placed on the wheelchair in order to protect tissues from PUs by minimising interface mechanical loads between the body and cushion and also, exposure to internal soft tissue loads. In this work, we studied the biomechanical performances of an off-loading (OL) cushion with limited adjustability, in comparison to a standard foam cushion and a fully adjustable air-cell-based (ACB) cushion...
September 6, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29024279/computed-tomographic-lymphography-as-a-complementary-technique-for-lymph-node-staging-in-dogs-with-malignant-tumors-of-various-sites
#17
Federica Rossi, Maximilian Körner, José Suárez, Gregorio Carozzi, Valeria S Meier, Malgorzata Roos, Carla Rohrer Bley
Locoregional lymph nodes are routinely examined in order to define the spatial extent of neoplastic disease. As draining patterns of certain tumor types can be divergent from expected anatomical distribution, it is critical to sample the lymph nodes truly representing the draining area. The aim of this bicenter prospective pilot study was to describe the technique of computed tomographic (CT)-lymphography for primary draining lymph node mapping in tumor staging in dogs. Forty-five dogs with macro- or microscopic tumors in specified localizations were evaluated...
October 11, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29023633/bdnf-and-bmi-effects-on-brain-structures-of-bipolar-offspring-results-from-the-global-mood-and-brain-science-initiative
#18
R B Mansur, E Brietzke, R S McIntyre, B Cao, Y Lee, L Japiassú, K Chen, R Lu, W Lu, T Li, G Xu, K Lin
OBJECTIVE: To compare brain-derived neurotrophic factor (BDNF) levels between offspring of individuals with bipolar disorders (BD) and healthy controls (HCs) and investigate the effects of BDNF levels and body mass index (BMI) on brain structures. METHOD: Sixty-seven bipolar offspring and 45 HCs were included (ages 8-28). Structural images were acquired using 3.0 Tesla magnetic resonance imaging. Serum BDNF levels were measured using enzyme-linked immunosorbent assay...
October 11, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29022681/body-image-dissatisfaction-and-weight-control-behaviour-in-slovak-adolescents
#19
Martina Bašková, Jana Holubčíková, Tibor Baška
OBJECTIVES: The aim of the study was to examine body-image dissatisfaction in adolescents aged 13-15 years reporting to be on a diet and to assess gender and age differences in weight-reduction behaviour in Slovak adolescents. METHODS: Data on a representative sample of 2,765 adolescents (mean age 14.37 years) from the Slovak part of Health Behaviour in School Aged Children Study carried out in 2014 were analysed. Self-reported body-image dissatisfaction and engagement in weight-reduction behaviour of 13 to 15-year-old adolescents was assessed using multiple logistic regression models...
September 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29022403/developmental-approach-for-behavior-learning-using-primitive-motion-skills
#20
Farhan Dawood, Chu Kiong Loo
Imitation learning through self-exploration is essential in developing sensorimotor skills. Most developmental theories emphasize that social interactions, especially understanding of observed actions, could be first achieved through imitation, yet the discussion on the origin of primitive imitative abilities is often neglected, referring instead to the possibility of its innateness. This paper presents a developmental model of imitation learning based on the hypothesis that humanoid robot acquires imitative abilities as induced by sensorimotor associative learning through self-exploration...
August 6, 2017: International Journal of Neural Systems
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