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https://www.readbyqxmd.com/read/27933369/imaging-mass-spectrometry-in-drug-development-and-toxicology
#1
REVIEW
Oskar Karlsson, Jörg Hanrieder
During the last decades, imaging mass spectrometry has gained significant relevance in biomedical research. Recent advances in imaging mass spectrometry have paved the way for in situ studies on drug development, metabolism and toxicology. In contrast to whole-body autoradiography that images the localization of radiolabeled compounds, imaging mass spectrometry provides the possibility to simultaneously determine the discrete tissue distribution of the parent compound and its metabolites. In addition, imaging mass spectrometry features high molecular specificity and allows comprehensive, multiplexed detection and localization of hundreds of proteins, peptides and lipids directly in tissues...
December 8, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27933280/bone-imaging-in-prostate-cancer-the-evolving-roles-of-nuclear-medicine-and-radiology
#2
REVIEW
Gary J R Cook, Gurdip Azad, Anwar R Padhani
The bone scan continues to be recommended for both the staging and therapy response assessment of skeletal metastases from prostate cancer. However, it is widely recognised that bone scans have limited sensitivity for disease detection and is both insensitive and non-specific for determining treatment response, at an early enough time point to be clinically useful. We, therefore, review the evolving roles of nuclear medicine and radiology for this application. We have reviewed the published literature reporting recent developments in imaging bone metastases in prostate cancer, and provide a balanced synopsis of the state of the art...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27932968/neurobiology-of-anorexia-nervosa-serotonin-dysfunctions-link-self-starvation-with-body-image-disturbances-through-an-impaired-body-memory
#3
REVIEW
Giuseppe Riva
The etiology of anorexia nervosa (AN) is still unclear, despite that it is a critical and potentially mortal illness. A recent neurobiological model considers AN as the outcome of dysfunctions in the neuronal processes related to appetite and emotionality (Kaye et al., 2009, 2013). However, this model still is not able to answer a critical question: What is behind body image disturbances (BIDs) in AN? The article starts its analysis from reviewing some of the studies exploring the effects of the serotonin systems in memory (episodic, working, and spatial) and its dysfunctions...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27932747/-a-rare-case-of-metastatic-brain-tumors-in-the-bilateral-cerebellopontine-angles
#4
Yasuhiro Node, Naoyuki Harada, Hiroyuki Masuda, Kosuke Kondo, Masaaki Nemoto, Nobuo Sugo
We encountered a rare case of metastatic brain tumors in the bilateral cerebellopontine angles. The patient was a 61-year-old man, who visited an otorhinolaryngology clinic with complaints of rapidly progressing bilateral hearing impairment and facial palsy. The patient was referred to our hospital because tumorous lesions were suspected in the bilateral cerebellopontine angles on brain magnetic resonance imaging. Regarding tumor markers, the patient's cancer antigen 19-9 and carcinoembryonic antigen levels were high, which suggested metastasis...
December 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27932687/diabetes-distress-among-persons-with-type-1-diabetes-associations-with-disordered-eating-depression-and-other-psychological-health-concerns
#5
Margaret A Powers, Sara A Richter, Diann M Ackard, Cheryl Craft
PURPOSE: The purpose of this study is to evaluate associations between diabetes distress and a range of psychological health behaviors and concerns among persons with type 1 diabetes for the benefit of enhancing early identification and intervention of at-risk individuals. METHODS: Persons with type 1 diabetes (n = 268; 57.1% female, 91.0% white, 76.8% <18 years of age, average A1C 8.4%) completed the 2-item Diabetes Distress Screening Scale (DDS2) and a battery of psychometrically sound instruments measuring satisfaction with life, self-esteem, self-efficacy, depression, perfectionism, body image satisfaction, dietary restraint and eating, and shape and weight concerns...
December 7, 2016: Diabetes Educator
https://www.readbyqxmd.com/read/27932557/quantitative-parameters-in-psma-targeted-pet-imaging-with-18f-dcfpyl-variability-in-normal-organ-uptake
#6
Xin Li, Steven P Rowe, Jeffrey P Leal, Michael A Gorin, Mohamad E Allaf, Ashley E Ross, Kenneth J Pienta, Martin A Lodge, Martin G Pomper
PURPOSE: (18)F-DCFPyL is a small-molecule inhibitor of the prostate-specific membrane antigen (PSMA) that has shown promise for evaluation of primary and metastatic prostate cancer (PC) using positron emission tomography (PET). Measuring the variability in normal organ uptake of (18)F-DCFPyL is necessary to understand its biodistribution, aid image interpretation, judge the reliability of scan quantification, and to provide a basis for therapeutic monitoring. METHODS: 65 consecutive (18)F-DCFPyL PET/CT scans from 64 patients with a history of PC were analyzed...
December 8, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27930760/body-image-disorders-and-abuse-of-anabolic-androgenic-steroids-among-men
#7
Harrison G Pope, Jag H Khalsa, Shalender Bhasin
No abstract text is available yet for this article.
December 8, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27930593/usefulness-of-3-dimensional-stereotactic-surface-projection-fdg-pet-images-for-the-diagnosis-of-dementia
#8
Jahae Kim, Sang-Geon Cho, Minchul Song, Sae-Ryung Kang, Seong Young Kwon, Kang-Ho Choi, Seong-Min Choi, Byeong-Chae Kim, Ho-Chun Song
To compare diagnostic performance and confidence of a standard visual reading and combined 3-dimensional stereotactic surface projection (3D-SSP) results to discriminate between Alzheimer disease (AD)/mild cognitive impairment (MCI), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD).[F]fluorodeoxyglucose (FDG) PET brain images were obtained from 120 patients (64 AD/MCI, 38 DLB, and 18 FTD) who were clinically confirmed over 2 years follow-up. Three nuclear medicine physicians performed the diagnosis and rated diagnostic confidence twice; once by standard visual methods, and once by adding of 3D-SSP...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929667/optimizing-mri-logistics-focused-process-improvements-can-increase-throughput-in-an-academic-radiology-department
#9
Jeremy J O'Brien, Jeremy Stormann, Kelli Roche, Ines Cabral-Goncalves, Annamarie Monks, Donna Hallett, Koenraad J Mortele
OBJECTIVE: The purpose of this study was to describe and evaluate the effect of focused process improvements on protocol selection and scheduling in the MRI division of a busy academic medical center, as measured by examination and room times, magnet fill rate, and potential revenue increases and cost savings to the department. MATERIALS AND METHODS: Focused process improvements, led by a multidisciplinary team at a large academic medical center, were directed at streamlining MRI protocols and optimizing matching protocol ordering to scheduling while maintaining or improving image quality...
December 8, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27929514/evaluation-of-kidney-motion-and-target-localization-in-abdominal-sbrt-patients
#10
Marcus Sonier, William Chu, Nafisha Lalani, Darby Erler, Patrick Cheung, Renee Korol
The purpose of this study was to evaluate bilateral kidney and target translational/rotational intrafraction motion during stereotactic body radiation therapy treatment delivery of primary renal cell carcinoma and oligometastatic adrenal lesions for patients immobilized in the Elekta BodyFIX system. Bilateral kidney motion was assessed at midplane for 30 patients immobilized in a full-body dual-vacuum-cushion system with two patients immobilized via abdominal compression. Intrafraction motion was assessed for 15 patients using kilovoltage cone-beam computed tomography (kV-CBCT) datasets (n = 151) correlated to the planning CT...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27929507/evaluation-of-digital-radiography-practice-using-exposure-index-tracking
#11
Alexander W Scott, Yifang Zhou, Janet Allahverdian, Jessica L Nute, Christina Lee
Some digital radiography (DR) detectors and software allow for remote download of exam statistics, including image reject status, body part, projection, and exposure index (EI). The ability to have automated data collection from multiple DR units is conducive to a quality control (QC) program monitoring institutional radiographic exposures. We have implemented such a QC program with the goal to identify outliers in machine radiation output and opportunities for improvement in radiation dose levels. We studied the QC records of four digital detectors in greater detail on a monthly basis for one year...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27929474/a-simple-one-step-dissection-protocol-for-whole-mount-preparation-of-adult-drosophila-brains
#12
Antonio J Tito, Shebna Cheema, Mian Jiang, Sheng Zhang
There is an increasing interest in using Drosophila to model human brain degenerative diseases, map neuronal circuitries in adult brains, and study the molecular and cellular basis of higher brain functions. A whole-mount preparation of adult brains with well-preserved morphology is critical for such whole brain-based studies, but can be technically challenging and time-consuming. This protocol describes an easy-to-learn, one-step dissection approach of an adult fly head in less than 10 s, while keeping the intact brain attached to the rest of the body to facilitate subsequent processing steps...
December 1, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27929468/using-linear-agarose-channels-to-study-drosophila-larval-crawling-behavior
#13
Xiao Sun, Ellie S Heckscher
Drosophila larval crawling is emerging as a powerful model to study neural control of sensorimotor behavior. However, larval crawling behavior on flat open surfaces is complex, including: pausing, turning, and meandering. This complexity in the repertoire of movement hinders detailed analysis of the events occurring during a single crawl stride cycle. To overcome this obstacle, linear agarose channels were made that constrain larval behavior to straight, sustained, rhythmic crawling. In principle, because agarose channels and the Drosophila larval body are both optically clear, the movement of larval structures labeled by genetically-encoded fluorescent probes can be monitored in intact, freely-moving larvae...
November 26, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27929179/sub-6-nm-monodisperse-hexagonal-core-shell-nagdf4-nanocrystals-with-enhanced-upconversion-photoluminescence
#14
Jing Liu, Guanying Chen, Shuwei Hao, Chunhui Yang
The ability to fabricate lanthanide-doped upconversion nanocrystals (UCNCs) with tailored size and emission profile has fuelled their uses in a broad spectrum of biological applications. Yet, limited success has been met in the preparation of sub-6 nm UCNCs with efficient upconversion photoluminescence (UCPL), which enable high contrast optical bioimaging with minimized adverse biological effects entailed by size-induced rapid clearance from the body. Here, we present a simple and reproducible approach to synthesize a set of monodispersed hexagonal-phase core NaGdF4:Yb/Ln (Ln = Er, Ho, Tm) of ∼3-4 nm and core/shell NaGdF4:Yb/Ln@NaGdF4 (Ln = Er, Ho, Tm) UCNCs of ∼5-6 nm...
December 8, 2016: Nanoscale
https://www.readbyqxmd.com/read/27928786/-implementation-of-multidisciplinary-team-in-the-diagnosis-and-treatment-of-gastroenteropancreatic-neuroendocrine-neoplasm
#15
Panpan Zhang, Lin Shen
Multidisciplinary team(MDT) has been considered as the best practice in the treatment planning and care for patients with cancer around the world. With the increased range and number of specialists involved, multidisciplinary coordination and communication have been enhanced, and the efficiency and quality of diagnosis and treatment of cancer have been improved. Neuroendocrine neoplasm (NEN) is a heterogeneous group of tumors originating from neuroendocrine cells located throughout the body, most of which is gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN)...
November 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27928228/multi-phase-post-mortem-ct-angiography-a-pathologic-correlation-study-on-cardiovascular-sudden-death
#16
Emanuela Turillazzi, Paola Frati, Natascha Pascale, Cristoforo Pomara, Giampaolo Grilli, Rocco Valerio Viola, Vittorio Fineschi
Multi-phase post-mortem CT-angiography (MPMCTA) has the great potential to increase the quality of the post-mortem investigation, especially in the area of sudden death; however, its role as routine complement to the pathology toolbox is still questioned as it needs to be further standardized. The aim of this study is to investigate the contribution of MPMCTA in cases of sudden unexplained death in adults and in particular in sudden cardiovascular death. Sixty-eight sudden unexpected deaths of adults were investigated at our institution between 2012 and 2013...
October 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27928222/performance-of-dual-source-ct-with-high-pitch-spiral-mode-for-coronary-stent-patency-compared-with-invasive-coronary-angiography
#17
Xia Yang, Qiang Yu, Wei Dong, Zhen-Hong Fu, Jun-Jue Yang, Jun Guo, Yun-Dai Chen
OBJECTIVE: To investigate the performance of dual-source computed tomography (DSCT) using high-pitch spiral (HPS) mode for coronary stents patency. METHODS: We conducted a prospective study on 120 patients with 260 previous stents implanted due to recurred suspicious symptoms of angina scheduled for invasive coronary angiography (ICA), while DSCT were conducted using HPS mode. RESULTS: There was no significant impact of age, body mass index or heat rate (HR) on image quality (P > 0...
October 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27927566/the-development-of-thoracic-vertebral-sagittal-morphology-during-childhood
#18
Ozgur Dede, Kadir Büyükdogan, Halil Gökhan Demirkıran, Erhan Akpınar, Muharrem Yazıcı
STUDY DESIGN: This is a cross-sectional descriptive study objectives to describe normal development of thoracic vertebrae during childhood and document contribution of individual vertebral shape to the sagittal alignment. SUMMARY OF BACKGROUND DATA: Sagittal spinal alignment changes during growth. The changes in sagittal alignment during adolescent growth spurt as well as the individual shapes of thoracic vertebrae have been implicated as factors for the development of adolescent idiopathic scoliosis (AIS)...
November 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927492/investigating-the-universality-of-preoperative-health-related-quality-of%C3%A2-life-hrqol-for-surgically-treated-spinal-deformity-in-young-adults-a-propensity-score-matched-comparison-between-african-and%C3%A2-us-populations
#19
Bradley Y Harris, Matthew F Roth, Bassel G Diebo, Shay Bess, Alexander A Theologis, Justin K Scheer, Frank J Schwab, Virginie Lafage, Christopher P Ames, Richard Hodes, Jennifer Ayamga, Oheneba Boachie-Adjei
STUDY DESIGN: Retrospective analysis of propensity score-matched (PSM) observational cohorts. OBJECTIVES: To evaluate and compare preoperative health-related quality of life (HRQoL) scores and radiographic measurements of young African and US adults with spinal deformity (ASD). SUMMARY OF BACKGROUND DATA: Young ASD patients in the United States are motivated more to correct coronal and sagittal plane deformities than to alleviate pain. Motivations for surgical correction in young ASD patients in Africa have not been previously investigated...
September 2016: Spine Deformity
https://www.readbyqxmd.com/read/27926733/high-resolution-mapping-of-global-surface-water-and-its-long-term-changes
#20
Jean-François Pekel, Andrew Cottam, Noel Gorelick, Alan S Belward
The location and persistence of surface water (inland and coastal) is both affected by climate and human activity and affects climate, biological diversity and human wellbeing. Global data sets documenting surface water location and seasonality have been produced from inventories and national descriptions, statistical extrapolation of regional data and satellite imagery, but measuring long-term changes at high resolution remains a challenge. Here, using three million Landsat satellite images, we quantify changes in global surface water over the past 32 years at 30-metre resolution...
December 7, 2016: Nature
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