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Enthesitis related arthritis

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https://www.readbyqxmd.com/read/27900348/implementation-of-musculoskeletal-ultrasonography-in-detection-of-early-juvenile-idiopathic-arthritis
#1
Ayman F Darwish, Faten M Ismael, Abdou Ell-Laban, Ahmed Hamed, Moustafa Abdel Kader, Ashraf Osman
AIM: To determine whether early clinical, laboratory and musculoskeletal ultrasound (MSUS) characteristics can be used as early detectors of juvenile idiopathic arthritis. PATIENTS AND METHODS: Forty (40) patients with juvenile idiopathic arthritis (JIA) diagnosed according to the ILAR criteria [1] and 20 healthy control children. All patients were subjected to the following assessment at base line and at follow up after 6 months: Clinical evaluation, MSUS examination and laboratory evaluation...
2016: European Journal of Radiology Open
https://www.readbyqxmd.com/read/27882408/-evidence-based-recommendations-on-diagnostics-and-therapy-of-axial-spondyloarthritis-s3-guidelines-of-the-german-society-of-rheumatology-dgrh-in-cooperation-with-the-association-of-the-scientific-medical-societies-in-germany-awmf
#2
REVIEW
U Kiltz, M Rudwaleit, J Sieper, J Braun
The clinical course of axial spondyloarthritis (SpA) is variable and characterized by chronic back pain and extraspinal manifestations, such as asymmetrical arthritis, dactylitis and enthesitis. Extra-articular manifestations in the eyes (anterior uveitis), skin (psoriasis) and intestines (chronic inflammatory bowel disease) are also frequent manifestations in patients with SpA. Due to the heterogeneity of disease manifestations and the partial concentration on structural alterations in the sacroiliac joints visible in X‑ray images, the diagnosis is often delayed for many years...
November 23, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27861762/gut-microbiome-in-children-with-enthesitis-related-arthritis-in-a-developing-country-and-the-effect-of-probiotic-administration
#3
Amita Aggarwal, Aditya N Sarangi, Priyanka Gaur, Anuj Shukla, Rakesh Aggarwal
In Asia, enthesitis-related arthritis (ERA) is the most-frequent category of juvenile idiopathic arthritis. ERA has a strong association with HLA-B27 and subclinical gut inflammation. In a HLA-B27 transgenic rat model, presence of Bacteroides bacteria in the gut appears to cause spondyloarthropathy (SpA). Thus, we studied gut microbiota in children with ERA. Stool specimens from 33 patients with ERA and 14 age-matched healthy controls were studied; none had any gastrointestinal symptom, or had received a drug known to affect gut motility or microbiota in the preceding 6 weeks...
November 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27833598/alteration-of-fecal-microbiota-profiles-in-juvenile-idiopathic-arthritis-associations-with-hla-b27-allele-and-disease-status
#4
Monica Di Paola, Duccio Cavalieri, Davide Albanese, Maddalena Sordo, Massimo Pindo, Claudio Donati, Ilaria Pagnini, Teresa Giani, Gabriele Simonini, Alessia Paladini, Paolo Lionetti, Carlotta De Filippo, Rolando Cimaz
Alteration of gut microbiota is involved in several chronic inflammatory and autoimmune diseases, including rheumatoid arthritis, and gut microbial "pro-arthritogenic" profiles have been hypothesized. Intestinal inflammation may be involved in spondyloarthropathies and in a subset of patients affected by Juvenile Idiopathic Arthritis (JIA), the most common chronic rheumatic disease of childhood. We compared the fecal microbiota composition of JIA patients with healthy subjects (HS), evaluating differences in microbial profiles between sub-categories of JIA, such as enthesitis-related arthritis (JIA-ERA), in which inflammation of entheses occurs, and polyarticular JIA, non-enthesitis related arthritis (JIA-nERA)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27796663/effect-of-ethnicity-on-disease-activity-and-physical-function-in-psoriatic-arthritis-in-a-multiethnic-asian-population
#5
Ying Ying Leung, Warren Fong, Nai Lee Lui, Julian Thumboo
Geographic differences in manifestation of psoriatic arthritis (PsA) could be related to differences in genetic or environmental factors. We aimed to compare the disease activity and functional status using validated outcome measures among patients with PsA of different ethnicities living in the same environment. We performed a cross-sectional study on consecutive patients with PsA classified by the Classification Criteria for Psoriatic Arthritis (CASPAR) criteria from a single center. Sociodemographic data, clinical variables, and patient-reported outcomes were collected using a standardized protocol...
October 30, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27786174/fecal-metabolomics-in-pediatric-spondyloarthritis-implicate-decreased-metabolic-diversity-and-altered-tryptophan-metabolism-as-pathogenic-factors
#6
M L Stoll, R Kumar, E J Lefkowitz, R Q Cron, C D Morrow, S Barnes
We have previously shown alterations in the composition of the gut microbiota in children with enthesitis-related arthritis (ERA). To explore the mechanisms by which an altered microbiota might predispose to arthritis, we performed metabolomic profiling of fecal samples of children with ERA. Fecal samples were collected from two cohorts of children with ERA and healthy control subjects. Nano-liquid chromatography-mass spectroscopy (LC-MS) was performed on the fecal water homogenates with identification based upon mass: charge ratios...
December 2016: Genes and Immunity
https://www.readbyqxmd.com/read/27785924/interleukin-33-as-a-marker-of-disease-activity-in-rheumatoid-factor-positive-polyarticular-juvenile-idiopathic-arthritis
#7
Sayaka Ishikawa, Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yasuo Nakagishi, Akihiro Yachie
OBJECTIVE: To investigate clinical usefulness of serum interleukin (IL)-33 levels as an indicator of disease activity in juvenile idiopathic arthritis (JIA). METHODS: We measured serum levels of IL-33 in 39 patients with JIA, including 7 patients with rheumatoid factor positive poly-JIA (RF + poly-JIA), 8 patients with RF negative poly-JIA (RF-poly-JIA), 20 patients with oligoarticular JIA (Oligo-JIA), 4 patients with enthesitis-related arthritis (ERA) and 30 age-matched healthy controls...
October 27, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27752356/juvenile-idiopathic-arthritis-in-adulthood-fulfilment-of-classification-criteria-for-adult-rheumatic-diseases-long-term-outcomes-and-predictors-of-inactive-disease-functional-status-and-damage
#8
Filipa Oliveira-Ramos, Mónica Eusébio, Fernando M Martins, Ana Filipa Mourão, Carolina Furtado, Raquel Campanilho-Marques, Inês Cordeiro, Joana Ferreira, Marcos Cerqueira, Ricardo Figueira, Iva Brito, Helena Canhão, Maria José Santos, José A Melo-Gomes, João Eurico Fonseca
OBJECTIVES: To determine how adult juvenile idiopathic arthritis (JIA) patients fulfil classification criteria for adult rheumatic diseases, evaluate their outcomes and determine clinical predictors of inactive disease, functional status and damage. METHODS: Patients with JIA registered on the Rheumatic Diseases Portuguese Register (Reuma.pt) older than 18 years and with more than 5 years of disease duration were included. Data regarding sociodemographic features, fulfilment of adult classification criteria, Health Assessment Questionnaire, Juvenile Arthritis Damage Index-articular (JADI-A) and Juvenile Arthritis Damage Index-extra-articular (JADI-E) damage index and disease activity were analysed...
2016: RMD Open
https://www.readbyqxmd.com/read/27750274/predictors-of-response-to-tnf-blockers-in-patients-with-polyarticular-psoriatic-arthritis
#9
Pedro David Carvalho, Cátia Duarte, Elsa Vieira-Sousa, Luís Cunha-Miranda, Pedro Avila-Ribeiro, Helena Santos, Miguel Bernardes, Maria José Santos, Marcos Cerqueira, Margarida Mateus, Patrícia Nero, Ana Águeda, José António Pereira da Silva, Pedro Machado
Psoriatic arthritis (PsA) is a chronic inflammatory rheumatic disease with a broad clinical spectrum. PsA can affect the axial skeleton, peripheral joints, entheses, synovial sheaths of tendons, skin, nails and extra-articular organs. Tumour necrosis factor alpha blockers (TNF blockers) were a breakthrough development in the treatment of PsA. Identifying predictors of response to biological therapies in patients with PsA is of utmost importance, especially in view of the costs and potential side effects of these agents...
August 17, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27738838/elevated-levels-of-serum-mrp8-14-in-ankylosing-spondylitis-associated-with-peripheral-arthritis-and-active-disease
#10
Latika Gupta, Shruti Bhattacharya, Vikas Agarwal, Amita Aggarwal
Monocytes of patients with ankylosing spondylitis (AS) have toll-like receptor 4 (TLR4) overexpression on their monocytes. Myeloid-related protein (MRP) 8/14 protein complexes are calcium-binding proteins, which act as endogenous ligands to TLR4. Thus, we studied the levels of MRP8/14 in adult AS patients. MRP8/14 levels were assessed in 99 adult AS patients satisfying Assessments in Ankylosing Spondylitis International Society 2010 criteria and 71 healthy controls by ELISA. Patient disease parameters like patient and physician global assessment, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), swollen and tender joint count, entheseal count by Maastricht enthesitis index, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were also recorded...
October 13, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27706807/intermediate-monocytes-are-increased-in-enthesitis-related-arthritis-a-category-of-juvenile-idiopathic-arthritis
#11
P Gaur, A Myles, R Misra, A Aggarwal
Microarray of peripheral blood (PB) and synovial fluid mononuclear cells (PBMC, SFMC) of patients with juvenile idiopathic arthritis-enthesitis-related arthritis (JIA-ERA) has shown the involvement of monocytes. On the basis of CD14 and CD16 expression, monocytes are classified as classical, intermediate and non-classical. In response to Toll-like receptor (TLR) stimulation, intermediate monocytes produce proinflammatory cytokines and play a role in inflammatory diseases. Therefore, we have studied the microarray profile of monocytes, the frequency of their subsets and cytokine production...
October 5, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27651193/-serum-levels-of-th1-th2-cytokines-in-children-with-non-systemic-juvenile-idiopathic-arthritis
#12
Jiang Lijiao, L U Meiping, Guo Li, W U Jianqiang, Zou Lixia, X U Yiping
Objective: To investigate the serum levels of Th1/Th2 cytokines in children with non-systemic juvenile onset idiopathic arthritis (non-SOJIA). Methods: Clinical data of 41 children with non-SOJIA, including 11 cases of polyarthritis, 10 cases of oligoarthritis and 20 cases of enthesitis related JIA (ERA), admitted in Children's Hospital of Zhejiang University School of Medicine during November 2012 and May 2015 were retrospectively analyzed. Serum levels of Th1/Th2 cytokines including IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ were measured by flow cytometry in patients with non-SOJIA, and compared with those in patients with SOJIA (SOJIA group, n=85) and healthy children (control group, n=202); their correlations with erythrocyte sedimentation rate and C reactive protein and CRP were analyzed...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/27607572/a-national-survey-on-the-management-of-psoriatic-arthritis-using-the-delphi-method
#13
Ennio Lubrano, Fabrizio Cantini, Alessandro Mathieu, Ignazio Olivieri, Carlo Salvarani, Raffaele Scarpa, Antonio Marchesoni
OBJECTIVES: Accurate diagnosis and appropriate management of psoriatic arthritis (PsA) is essential to avoid unnecessary morbidity. Our aim in this study was to evaluate the current approach to the management of PsA among rheumatologists. METHODS: A 16-item online questionnaire, produced using the Delphi method, was submitted to a panel of rheumatologists who anonymously expressed their opinions on a scale from 1 (maximum disagreement) to 5 (maximum agreement). Positive consensus was defined by ≥66% of the respondents scoring an item 3, 4 or 5...
August 31, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27466726/update-on-enthesitis-related-arthritis
#14
Pamela F Weiss
PURPOSE OF REVIEW: This review provides a detailed update regarding the genetics, pathogenesis, disease phenotype evaluation, therapies and expected outcomes for children with enthesitis-related arthritis (ERA). RECENT FINDINGS: Recent studies evaluated human leukocyte antigen (HLA)-B27 subtypes and non-major histocompatibility complex genes including toll like receptor 4, NLRP3, CXCR4 and PTPN12 in children with ERA. The microbiome and γδ-T cells have also been an area of active investigation...
September 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27464779/ustekinumab-as-a-therapeutic-option-for-children-with-refractory-enthesitis-related-arthritis
#15
Melissa L Mannion, Linda McAllister, Randy Q Cron, Matthew L Stoll
No abstract text is available yet for this article.
August 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27422803/treatment-prescribing-patterns-in-patients-with-juvenile-idiopathic-arthritis-jia-analysis-from-the-uk-childhood-arthritis-prospective-study-caps
#16
Rebecca Davies, Roberto Carrasco, Helen E Foster, Eileen M Baildam, S E Alice Chieng, Joyce E Davidson, Yiannis Ioannou, Lucy R Wedderburn, Wendy Thomson, Kimme L Hyrich
OBJECTIVE: Initial treatment of juvenile idiopathic arthritis (JIA) is largely based on the extent of joint involvement, disease severity and ILAR category. The licensing of biologic therapies for JIA has expanded treatment options. The aims of the study are (1) to describe treatment prescribing patterns in JIA over the first 3 years following first presentation to paediatric rheumatology and (2) to determine whether patterns of treatment have changed as biologics have become more widely available...
October 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27411808/hla-b27-typing-in-511-children-with-juvenile-idiopathic-arthritis-from-india
#17
Rajni Srivastava, Sanat Phatak, Akhilesh Yadav, Preeti Bajpai, Amita Aggarwal
The enthesitis-related arthritis (ERA) category of juvenile idiopathic arthritis (JIA) is the most common category in India. HLA B27 has a high prevalence in ERA, and ILAR classification includes it in exclusion criteria for other categories, but due to its cost, it is not routinely done. We undertook this study to assess the prevalence of HLA B27 in ERA and other groups of juvenile arthritis in India. Consecutive patients of JIA ERA and select patients from other categories were recruited from a single tertiary care hospital over a span of 3 years...
October 2016: Rheumatology International
https://www.readbyqxmd.com/read/27385618/methotrexate-treatment-may-prevent-uveitis-onset-in-patients-with-juvenile-idiopathic-arthritis-experiences-and-subgroup-analysis-in-a-cohort-with-frequent-methotrexate-use
#18
Mikhail M Kostik, Ekaterina V Gaidar, Alla Y Hynnes, Margarita F Dubko, Vera V Masalova, Ludmil S Snegireva, Irina A Chikova, Eugenia A Isupova, Tatiana N Nikitina, Elena D Serogodskaya, Olga V Kalashnikova, Angelo Ravelli, Vyacheslav G Chasnyk
OBJECTIVES: To re-evaluate the ability of methotrexate (MTX) to prevent the onset of uveitis in Russian children with juvenile idiopathic arthritis (JIA). METHODS: The clinical charts for all consecutive patients who received a stable management for at least 2 years with or without MTX were reviewed. Patients who were given systemic medications other than MTX (except NSAID) and patients with systemic arthritis, rheumatoid factor-positive arthritis, or enthesitis-related arthritis were excluded...
July 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27376529/discordant-inflammatory-changes-in-the-apophyseal-and-sacroiliac-joints-serial-observations-in-enthesitis-related-arthritis
#19
Timothy J P Bray, Thomas Amies, Kanimozhi Vendhan, Paul Humphries, Debajit Sen, Yiannis Ioannou, Margaret A Hall-Craggs
OBJECTIVE: To determine the extent to which inflammation of the sacroiliac joints (SIJs) and apophyseal joints (AJs) changes concordantly after treatment in enthesitis-related arthritis (ERA). METHODS: A retrospective study was performed with institutional review board approval. 31 young patients with ERA who had been scanned between March 2009 and November 2014 were included. All patients had post-contrast imaging of the SIJs and lumbar spine and short tau inversion-recovery (STIR) images of the SIJs...
September 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27371647/clinical-usefulness-of-18f-fluorodeoxyglucose-positron-emission-tomography-for-enthesitis-related-arthritis-diagnosis
#20
Natsumi Inoue, Mao Mizuta, Masaki Shimizu
No abstract text is available yet for this article.
July 2016: Journal of Rheumatology
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