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Enthesitis related arthritis

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https://www.readbyqxmd.com/read/28494794/juvenile-idiopathic-arthritis-in-relation-to-perinatal-and-maternal-characteristics-a-case-control-study
#1
Samantha W Bell, Susan Shenoi, J Lee Nelson, Parveen Bhatti, Beth A Mueller
BACKGROUND: Existing data on associations between maternal and early childhood exposures and juvenile idiopathic arthritis (JIA) risk is scant and inconsistent with previous studies showing potential role for prematurity, number of siblings and infections. We explored JIA and International League of Associations for Rheumatology (ILAR) JIA categories in relation to selected infant (birthweight, size-for-gestational-age, gestational age), and maternal (parity, delivery type, prior fetal loss) characteristics that may be markers for exposures related to two pathways (hygiene hypothesis, microchimerism) potentially associated with autoimmune disorder occurrence...
May 11, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28488045/-musculoskeletal-manifestations-of-sarcoidosis
#2
REVIEW
P Korsten, G Chehab
Musculoskeletal manifestations in the context of sarcoidosis are frequently observed. The rheumatologist regularly encounters this disease in clinical practice. In the present review, we aim to give a current overview of the manifestations and treatments relevant to the practicing rheumatologist. The most frequently encountered manifestation is Lofgren's syndrome, which is characterized by bilateral ankle periarthritis, bilateral hilar lymphadenopathy, and erythema nodosum and has an excellent prognosis. Chronic arthropathy most commonly manifests as oligoarthritis, which sometimes hampers its differentiation from spondylarthropathies, especially when sacroiliitis, enthesitis or dactylitis are simultaneously present...
May 9, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28464909/multicenter-inception-cohort-of-enthesitis-related-arthritis-variation-in-disease-characteristics-and-treatment-approaches
#3
Sabrina Gmuca, Rui Xiao, Timothy G Brandon, Ilaria Pagnini, Tracey B Wright, Timothy Beukelman, Esi M Morgan, Pamela F Weiss
BACKGROUND: Enthesitis-related arthritis (ERA) is a specific subtype of juvenile idiopathic arthritis (JIA) defined according to the International League of Associations for Rheumatology (ILAR) criteria. We aimed to characterize the clinical features and treatment regimens in an inception cohort of children with ERA. METHODS: We performed a retrospective, cross-sectional, multicenter cohort study including subjects diagnosed with ERA between 1989 and 2012. Patients all fulfilled the ILAR criteria for ERA within 3 months of initial presentation to the rheumatology clinic...
May 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28426894/characteristics-and-course-of-enthesitis-in-a-juvenile-idiopathic-arthritis-inception-cohort
#4
Dax G Rumsey, Jaime Guzman, Alan M Rosenberg, Adam M Huber, Rosie Scuccimarri, Natalie J Shiff, Alessandra Bruns, Brian M Feldman, Dean T Eurich
Objective To describe the prevalence, associated characteristics, and course of enthesitis in a juvenile idiopathic arthritis (JIA) inception cohort. Methods Canadian children newly diagnosed with JIA between 2005 and 2010 were categorized using ILAR criteria at the 6-month visit and followed in the ReACCh-Out cohort for up to 5 years. The presence of entheseal tenderness on examination at 33 sites shown on a homunculus was recorded at 0, 6, 12, 18, 24, 36, 48 and 60 months after enrolment. Enthesitis was defined as entheseal tenderness at more than one site or on more than one occasion...
April 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28418334/juvenile-idiopathic-arthritis
#5
Kenan Barut, Amra Adrovic, Sezgin Şahin, Özgür Kasapçopur
Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Oligoarticular juvenile idiopathic arthritis, common among young female patients, is usually accompanied by anti-nuclear antibodie positivity and anterior uveitis...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28405472/course-of-patients-with-juvenile-spondyloarthritis-during-4%C3%A2-years-of-observation-juvenile-part-of-gespic
#6
Anja Weiß, Kirsten Minden, Joachim Listing, Ivan Foeldvari, Joachim Sieper, Martin Rudwaleit
OBJECTIVE: To describe the course and the 4-year outcome of juvenile spondyloarthritis (jSpA). METHODS: Patients with a diagnosis of jSpA and an age at onset ≤16 years were included in the German Spondyloarthritis Inception cohort (GESPIC) and followed up prospectively for 4 years. RESULTS: 118 patients (73% men, 66% HLA-B27 positive, mean age 13.5 years, mean symptom duration 2.2 years) were enrolled in 2 study centres: 52% of patients with jSpA were captured by the enthesitis-related arthritis subgroup of the International League of Associations for Rheumatology classification criteria...
2017: RMD Open
https://www.readbyqxmd.com/read/28380667/antibodies-to-citrullinated-peptides-in-patients-with-juvenile-idiopathic-arthritis-and-rheumatoid-arthritis-shared-expression-of-the-inherently-autoreactive-9g4-idiotype
#7
Hannah Peckham, Geraldine Cambridge, Lauren Bourke, Debajit Sen, Anna Radziszewska, Maria Leandro, Yiannis Ioannou
Objective Antibodies to cyclic citrullinated peptides (CCP) in rheumatoid arthritis (RA) can express the inherently autoreactive gene, VH4-34, as detected using the rat monoclonal antibody, 9G4. Patients with the polyarticular sub-type of juvenile idiopathic arthritis (pJIA) share some but not all features of RA in adults. The aim of this study was to profile rheumatoid factor (RF), anti-CCP and 9G4-CCP serology of a large JIA cohort and compare to a cohort of adult RA patients. Methods Serum from 88 pJIA, 29 enthesitis-related arthritis (ERA), 38 extended oligoarthritis (EOA), 31 adolescent controls, 35 RA and 30 adult controls were tested for RF, IgG, IgA and IgM anti-CCP and 9G4+CCP by ELISA...
April 5, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28320454/mitigation-of-disease-and-treatment-related-risks-in-patients-with-psoriatic-arthritis
#8
REVIEW
Martin Bergman, Amy Lundholm
Psoriatic arthritis is a part of the family of diseases referred to as spondyloarthropathies, a diverse group of chronic inflammatory disorders with common clinical, radiographic, and genetic features. Peripheral arthritis is the most common symptom of psoriatic arthritis and patients also frequently experience involvement of the entheses, spine, skin, and nails. Due to the diverse clinical spectrum of disease severity, tissues affected, and associated comorbidities, the treatment of psoriatic arthritis can be challenging and it is necessary to mitigate risks associated with both the disease and its treatment...
March 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28241879/time-to-diagnosis-in-juvenile-idiopathic-arthritis-a-french-perspective
#9
Laura Aoust, Linda Rossi-Semerano, Isabelle Koné-Paut, Perrine Dusser
BACKGROUND: Juvenile idiopathic arthritis (JIA) is a rare disease that is not widely known by paediatricians and general practitioner (GP) leading to diagnostic error and delayed care provision. We aimed to analyse patient's journey and time to diagnosis of JIA (delay from the first symptom to the diagnosis of JIA). We performed a retrospective cohort study of 67 patients diagnosed with JIA and seen in the paediatric rheumatology department of the Kremlin Bicêtre Hospital, between July 2002 and January 2015...
February 28, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28222745/psoriasis-and-associated-variables-in-classification-and-outcome-of-juvenile-idiopathic-arthritis-an-eight-year-follow-up-study
#10
Maria Ekelund, Kristiina Aalto, Anders Fasth, Troels Herlin, Susan Nielsen, Ellen Nordal, Suvi Peltoniemi, Marite Rygg, Marek Zak, Lillemor Berntson
BACKGROUND: To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA). METHODS: In all, 440 children with JIA were followed for a median of 8 years in a prospective Nordic population-based cohort study. Data for remission was available for 427 of these children. The presence of psoriasis, psoriasis-like rash, dactylitis, nail pitting, enthesitis, tenosynovitis and heredity was assessed in relation to ILAR classification and remission...
February 22, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28161768/erap1-rs30187-single-nucleotide-polymorphism-does-not-confer-disease-susceptibility-in-north-indian-children-with-enthesitis-related-arthritis
#11
Rajni Srivastava, Sanat Phatak, Amita Aggarwal
ERAP1 single nucleotide polymorphisms (SNP) are associated with ankylosing spondylitis. Data on ERAP1SNPs in juvenile idiopathic arthritis (JIA) is scarce. ERAP1 rs30187 SNP was shown to confer risk in the enthesitis-related arthritis (ERA) category of JIA. We examined the prevalence and association of this SNP in Indian children with ERA. SNPs in ERAP1 (rs30187) were genotyped in children with ERA (n = 271), ankylosing spondylitis (AS) (n = 213) and healthy controls (n = 101), using Taqman genotyping...
February 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28056736/investigation-of-associations-between-autoimmunity-associated-variants-in-pdcd1-and-juvenile-idiopathic-arthritis
#12
Christina I Tejeda, K Alaine Broadaway, Milton R Brown, Lori A Ponder, Michael J Ombrello, Mina Rohani Pichavant, Gabriel Wang, Sheila T Angeles-Han, Aimee O Hersh, John F Bohnsack, Karen N Conneely, Michael P Epstein, Sampath Prahalad
PURPOSE: Variants in the gene encoding Programmed Cell Death-1 (PDCD1) have been associated with susceptibility to Systemic Lupus Erythematosus and other autoimmune diseases. Given that clinically distinct autoimmune phenotypes share common genetic susceptibility factors, variants in PDCD-1 were tested for a possible association with Juvenile Idiopathic Arthritis (JIA). METHODS: Four single nucleotide polymorphisms (SNPS) in the PDCD1 gene were genotyped and analyzed: rs10204525, rs7568402, rs7421861 and rs11568821 in 834 cases and 855 self-identified Caucasian controls...
January 4, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27994095/diffusion-weighted-imaging-is-a-sensitive-biomarker-of-response-to-biologic-therapy-in-enthesitis-related-arthritis
#13
Timothy J P Bray, Kanimozhi Vendhan, Nicola Ambrose, David Atkinson, Shonit Punwani, Corinne Fisher, Debajit Sen, Yiannis Ioannou, Margaret A Hall-Craggs
OBJECTIVE: The aim was to evaluate diffusion-weighted imaging (DWI) as a tool for measuring treatment response in adolescents with enthesitis-related arthropathy (ERA). METHODS: Twenty-two adolescents with ERA underwent routine MRI and DWI before and after TNF inhibitor therapy. Each patient's images were visually scored by two radiologists using the Spondyloarthritis Research Consortium of Canada system, and sacroiliac joint apparent diffusion coefficient (ADC) and normalized ADC (nADC) were measured for each patient...
December 19, 2016: Rheumatology
https://www.readbyqxmd.com/read/27900348/implementation-of-musculoskeletal-ultrasonography-in-detection-of-early-juvenile-idiopathic-arthritis
#14
Ayman F Darwish, Faten M Ismael, Abdou Ell-Laban, Ahmed Hamed, Moustafa Abdel Kader, Ashraf Osman
AIM: To determine whether early clinical, laboratory and musculoskeletal ultrasound (MSUS) characteristics can be used as early detectors of juvenile idiopathic arthritis. PATIENTS AND METHODS: Forty (40) patients with juvenile idiopathic arthritis (JIA) diagnosed according to the ILAR criteria [1] and 20 healthy control children. All patients were subjected to the following assessment at base line and at follow up after 6 months: Clinical evaluation, MSUS examination and laboratory evaluation...
2016: European Journal of Radiology Open
https://www.readbyqxmd.com/read/27882408/-evidence-based-recommendations-on-diagnostics-and-therapy-of-axial-spondyloarthritis-s3-guidelines-of-the-german-society-of-rheumatology-dgrh-in-cooperation-with-the-association-of-the-scientific-medical-societies-in-germany-awmf
#15
REVIEW
U Kiltz, M Rudwaleit, J Sieper, J Braun
The clinical course of axial spondyloarthritis (SpA) is variable and characterized by chronic back pain and extraspinal manifestations, such as asymmetrical arthritis, dactylitis and enthesitis. Extra-articular manifestations in the eyes (anterior uveitis), skin (psoriasis) and intestines (chronic inflammatory bowel disease) are also frequent manifestations in patients with SpA. Due to the heterogeneity of disease manifestations and the partial concentration on structural alterations in the sacroiliac joints visible in X‑ray images, the diagnosis is often delayed for many years...
November 23, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27861762/gut-microbiome-in-children-with-enthesitis-related-arthritis-in-a-developing-country-and-the-effect-of-probiotic-administration
#16
A Aggarwal, A N Sarangi, P Gaur, A Shukla, R Aggarwal
In Asia, enthesitis-related arthritis (ERA) is the most frequent category of juvenile idiopathic arthritis. ERA has a strong association with human leucocyte antigen (HLA)-B27 and subclinical gut inflammation. In an HLA-B27 transgenic rat model, the presence of Bacteroides bacteria in the gut appears to cause spondyloarthropathy (SpA). Thus, we studied gut microbiota in children with ERA. Stool specimens from 33 patients with ERA and 14 age-matched healthy controls were studied; none had any gastrointestinal symptom, or had received a drug known to affect gut motility or microbiota in the preceding 6 weeks...
March 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27833598/alteration-of-fecal-microbiota-profiles-in-juvenile-idiopathic-arthritis-associations-with-hla-b27-allele-and-disease-status
#17
Monica Di Paola, Duccio Cavalieri, Davide Albanese, Maddalena Sordo, Massimo Pindo, Claudio Donati, Ilaria Pagnini, Teresa Giani, Gabriele Simonini, Alessia Paladini, Paolo Lionetti, Carlotta De Filippo, Rolando Cimaz
Alteration of gut microbiota is involved in several chronic inflammatory and autoimmune diseases, including rheumatoid arthritis, and gut microbial "pro-arthritogenic" profiles have been hypothesized. Intestinal inflammation may be involved in spondyloarthropathies and in a subset of patients affected by Juvenile Idiopathic Arthritis (JIA), the most common chronic rheumatic disease of childhood. We compared the fecal microbiota composition of JIA patients with healthy subjects (HS), evaluating differences in microbial profiles between sub-categories of JIA, such as enthesitis-related arthritis (JIA-ERA), in which inflammation of entheses occurs, and polyarticular JIA, non-enthesitis related arthritis (JIA-nERA)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27796663/effect-of-ethnicity-on-disease-activity-and-physical-function-in-psoriatic-arthritis-in-a-multiethnic-asian-population
#18
Ying Ying Leung, Warren Fong, Nai Lee Lui, Julian Thumboo
Geographic differences in manifestation of psoriatic arthritis (PsA) could be related to differences in genetic or environmental factors. We aimed to compare the disease activity and functional status using validated outcome measures among patients with PsA of different ethnicities living in the same environment. We performed a cross-sectional study on consecutive patients with PsA classified by the Classification Criteria for Psoriatic Arthritis (CASPAR) criteria from a single center. Sociodemographic data, clinical variables, and patient-reported outcomes were collected using a standardized protocol...
January 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/27786174/fecal-metabolomics-in-pediatric-spondyloarthritis-implicate-decreased-metabolic-diversity-and-altered-tryptophan-metabolism-as-pathogenic-factors
#19
M L Stoll, R Kumar, E J Lefkowitz, R Q Cron, C D Morrow, S Barnes
We have previously shown alterations in the composition of the gut microbiota in children with enthesitis-related arthritis (ERA). To explore the mechanisms by which an altered microbiota might predispose to arthritis, we performed metabolomic profiling of fecal samples of children with ERA. Fecal samples were collected from two cohorts of children with ERA and healthy control subjects. Nano-liquid chromatography-mass spectroscopy (LC-MS) was performed on the fecal water homogenates with identification based upon mass: charge ratios...
December 2016: Genes and Immunity
https://www.readbyqxmd.com/read/27785924/interleukin-33-as-a-marker-of-disease-activity-in-rheumatoid-factor-positive-polyarticular-juvenile-idiopathic-arthritis
#20
Sayaka Ishikawa, Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yasuo Nakagishi, Akihiro Yachie
OBJECTIVE: To investigate clinical usefulness of serum interleukin (IL)-33 levels as an indicator of disease activity in juvenile idiopathic arthritis (JIA). METHODS: We measured serum levels of IL-33 in 39 patients with JIA, including 7 patients with rheumatoid factor positive poly-JIA (RF + poly-JIA), 8 patients with RF negative poly-JIA (RF-poly-JIA), 20 patients with oligoarticular JIA (Oligo-JIA), 4 patients with enthesitis-related arthritis (ERA) and 30 age-matched healthy controls...
October 27, 2016: Modern Rheumatology
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