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Ventriculitis

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https://www.readbyqxmd.com/read/28051982/single-neurosurgeon-operative-experience-at-craig-joint-theater-hospital-during-the-afghanistan-surge-november-2010-to-april-2011-part-ii-humanitarian-cases
#1
John Joseph Steele
BACKGROUND: The Afghanistan Surge saw NATO troops working with their Afghan partners to remove Taliban governance and replace it with a more democratic model. As part of this endeavor, medical support for both trauma and humanitarian cases was needed. OBJECTIVE: Identify and discuss disease trends to better prepare for future combat medical treatments. METHODS: Retrospective review of operative experience from a neurosurgeon from November 2010 to April 2011...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28049348/invasive-mrsa-infections-in-neurosurgical-patients-a-decade-of-progress
#2
Mairéad Skally, Caoimhe Finn, David O'Brien, Fidelma Fitzpatrick, Karen Burns, Elaine McFadden, Margaret Fitzpatrick, Edmond Smyth, Hilary Humphreys
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of bloodstream infection (BSI), which is declining in many countries, including Ireland. However, it also causes other invasive infections, such as meningitis in neurosurgical patients. It is unclear whether the decline in MRSA BSI is reflected in other invasive infections and in specialist units. AIM: To investigate trends in the incidence of MRSA invasive infection in a national neurosurgical centre over a 10-year period...
January 3, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28041618/pyogenic-ventriculitis-and-ventricular-empyema-associated-with-staphylococcus-pseudintermedius-in-a-puppy
#3
S A Headley, L G Pretto-Giordano, D F Nóbrega, C S Altrão, L A Villas-Boas, A A Alfieri, A P F R L Bracarense
A 40-day-old male, blue heeler puppy with hindlimb ataxia, nystagmus, apathy, motor incoordination and hyperaesthesia of the forelimbs died 3 days after the onset of clinical signs. Significant gross findings included cerebellar herniation, cerebral oedema and dilation of the third and right lateral cerebral ventricles due to the accumulation of a purulent exudate. Histopathological examination revealed pyogenic ventriculitis and purulent meningoencephalitis. Pure colonies of a coagulase-positive Staphylococcus were isolated from the purulent cerebral exudate...
December 29, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28024977/external-ventricular-drain-related-infection-in-spontaneous-intracerebral-hemorrhage
#4
Samir Cezimbra Dos Santos, Telmo Tiburcio Fortes Lima, Luciano Werle Lunardi, Marco Antonio Stefani
OBJECTIVE: To analyze infection rates in a series of patients with spontaneous intracranial hemorrhage who underwent surgical external ventricular drain (EVD) placement. METHODS: This prospective study included patients who required EVD for spontaneous intracranial hemorrhage at the Neurosurgery Department of Hospital Cristo Redentor (HCR), Porto Alegre, Rio Grande do Sul, Brazil. Overall, 94 consecutive patients were included. RESULTS: The mean duration of EVD use was 7 days...
December 23, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28013184/variables-determining-mortality-in-patients-with-acinetobacter-baumannii-meningitis-ventriculitis-treated-with-intrathecal-colistin
#5
Bahadır Ceylan, Ferhat Arslan, Oguz Resat Sipahi, Mustafa Sunbul, Bahar Ormen, İsmail N Hakyemez, Tuba Turunc, Yeşim Yıldız, Hasan Karsen, Gul Karagoz, Recep Tekin, Burcu Hizarci, Vedat Turhan, Sebnem Senol, Nefise Oztoprak, Mesut Yılmaz, Kevser Ozdemir, Sinan Mermer, Omer F Kokoglu, Ali Mert
AIM: To examine the variables associated with mortality in patients with Acinetobacter baumannii-related central nervous system infections treated with intrathecal colistin. MATERIALS AND METHODS: This multi-centre retrospective case control study included patients from 11 centres in Turkey, as well as cases found during a literature review. Only patients with CNS infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii treated with intrathecal colistin were included in this study...
December 14, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28012890/a-simple-infection-control-protocol-durably-reduces-external-ventricular-drain-infections-to-near-zero-levels
#6
Alexander C Flint, Shahed Toossi, Sheila L Chan, Vivek A Rao, William Sheridan
OBJECTIVE: External ventricular drains (EVDs) historically have a high rate of infection, and EVD infections are a cause of significant morbidity and mortality. We have previously shown that a simple infection control protocol reduced the rate of EVD infections over a 3-year period, and the present study examines whether infection rates were durably reduced over an additional 4 years. METHODS: Retrospective analysis of EVDs placed in the ICU of a tertiary Neurosurgical center over an additional 4 year follow-up period...
December 21, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28004332/clinical-and-laboratory-characteristics-for-the-diagnosis-of-bacterial-ventriculitis-after-aneurysmal-subarachnoid-hemorrhage
#7
J Hoogmoed, D van de Beek, B A Coert, J Horn, W P Vandertop, D Verbaan
BACKGROUND: The diagnosis of nosocomial bacterial ventriculitis in patients with subarachnoid hemorrhage (SAH) can be challenging. METHODS: We performed a retrospective study on the diagnostic accuracy of clinical and laboratory characteristics for the diagnosis of bacterial ventriculitis in 209 consecutive patients with an aneurysmal SAH admitted in a tertiary referral center from 2008 to 2010. Diagnostic value of clinical characteristics and inflammatory indexes in CSF and blood were determined for three diagnostic categories: (1) no suspicion for bacterial ventriculitis; (2) clinical suspicion for bacterial ventriculitis, defined as initiation of empirical antibiotic treatment for ventriculitis, but negative CSF cultures; and (3) CSF culture-positive bacterial ventriculitis...
December 21, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27989973/management-of-pyogenic-cerebral-ventriculitis-by-neuroendoscopic-surgery
#8
Fei Wang, Xiao-Yan Yao, Zhi-Rong Zou, Hua-Lin Yu, Tao Sun
BACKGROUND: Pyogenic cerebral ventriculitis is a debilitating form of intracranial infection with an unfavorable outcome due to lack of experience in surgical management. OBJECTIVE: To study retrospectively a group of pyogenic cerebral ventriculitis patients managed by neuroendoscopic surgery (NES). METHODS: The standard intraventricular protocols of NES to treat this disease included 1 or more of the following: (1) to obliterate debris, (2) to observe evidence of microbial infection, (3) to perform septomy, (4) to incise the septation, or (5) to monitor catheter insertion...
October 27, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27955815/salmonella-meningitis-associated-with-monocyte-infiltration-in-mice
#9
Timothy J Bauler, Tregei Starr, Toni A Nagy, Sushmita Sridhar, Dana Scott, Clayton W Winkler, Olivia Steele-Mortimer, Corrella S Detweiler, Karin E Peterson
In the current study, we examined the ability of Salmonella enterica serovar Typhimurium to infect the central nervous system and cause meningitis following the natural route of infection in mice. C57BL/6J mice are extremely susceptible to systemic infection by Salmonella Typhimurium because of loss-of-function mutations in Nramp1 (SLC11A1), a phagosomal membrane protein that controls iron export from vacuoles and inhibits Salmonella growth in macrophages. Therefore, we assessed the ability of Salmonella to disseminate to the central nervous system (CNS) after oral infection in C57BL/6J mice expressing either wild-type (resistant) or mutant (susceptible) alleles of Nramp1...
January 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/27931942/interleukin-6-in-the-cerebrospinal-fluid-as-biomarker-for-onset-of-vasospasm-and-ventriculitis-after-severe-subarachnoidal-hemorrhage
#10
Markus Lenski, Volker Huge, Josef Briegel, Jörg-Christian Tonn, Christian Schichor, Niklas Thon
OBJECTIVE: Study aim was to investigate the diagnostic potential of Interleukin-6(IL-6) and other soluble biomarkers in serum and cerebrospinal fluid(CSF) for early diagnosis of cerebral vasospasm (cVSSAH) and external ventricular drainage (EVD) associated ventriculitis (VCSAH) and to separate these conditions from aneurysmal subarachnoidal hemorrhage (aSAH) without further complication (SAH(w/o/c)). METHODS: The concentrations of serum biomarkers and markers in the CSF were collected in 63 consecutive patients with aSAH and EVD...
December 5, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27867829/intrathecal-intraventricular-linezolid-in-multidrug-resistant-enterococcus-faecalis-ventriculitis
#11
Brian F Lich, Andrew K Conner, Joshua D Burks, Chad A Glenn, Michael E Sughrue
Background The use of intrathecal antibiotic therapy for the treatment of ventriculitis and/or meningitis has demonstrated efficacy especially when sterilization of the cerebrospinal fluid is not possible with intravenous antibiotics alone. Case Description We describe the successful treatment of Enterococcus faecalis ventriculitis utilizing intrathecal linezolid in a 32-year-old female patient with severe allergy to vancomycin, prohibitive bacterial susceptibilities, and failure of previous attempts to sterilize the cerebrospinal fluid despite multimodal treatment...
October 2016: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/27856824/all-trans-retinoic-acid-augments-the-histopathological-outcome-of-neuroinflammation-and-neurodegeneration-in-lupus-prone-mrl-lpr-mice
#12
Michelle H Theus, Joshua B Sparks, Xiaofeng Liao, Jingjing Ren, Xin M Luo
Recently, we demonstrated that treatment with all-trans-retinoic acid (tRA) induced a paradoxical effect on immune activation during the development of autoimmune lupus. Here, we further describe its negative effects on mediating neuroinflammation and neurodegeneration. Female MRL/lpr mice were orally administered tRA or VARA (retinol mixed with 10% tRA) from 6 to 14 weeks of age. Both treatments had a significant effect on brain weight, which correlated with histopathological evidence of focal astrogliosis, meningitis, and ventriculitis...
November 16, 2016: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/27851453/1818-intracranial-hemorrhage-with-hypertriglyceridemia-mimicking-empyema-and-ventriculitis
#13
Bryan Gough, Diana Greene-Chandos
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27796704/precipitous-neurologic-decline-following-intraventricular-rupture-of-a-cerebral-abscess-classic-imaging-findings-in-ventriculitis-and-pyocephalus
#14
EDITORIAL
Mougnyan Cox, Manisha Patel, Vishal Kukkar, Pranshu Sharma
No abstract text is available yet for this article.
October 27, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27776537/cerebrospinal-fluid-penetration-of-meropenem-in-neurocritical-care-patients-with-proven-or-suspected-ventriculitis-a-prospective-observational-study
#15
Ute Blassmann, Anka C Roehr, Otto R Frey, Cornelia Vetter-Kerkhoff, Niklas Thon, William Hope, Josef Briegel, Volker Huge
BACKGROUND: Ventriculitis is a complication of temporary intraventricular drains. The limited penetration of meropenem into the cerebrospinal fluid (CSF) is well known. However, ventricular CSF pharmacokinetic data in patients with ventriculitis are lacking. The aim of this study was to evaluate meropenem pharmacokinetics in the serum and CSF of neurocritical care patients with proven or suspected ventriculitis. METHODS: We conducted an observational pharmacokinetic study of neurocritical care patients with proven or suspected ventriculitis receiving meropenem...
October 24, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27756489/surveillance-of-infection-associated-with-external-ventricular-drains-proposed-methodology-and-results-from-a-pilot-study
#16
H Humphreys, P Jenks, J Wilson, V Weston, R Bayston, C Waterhouse, A Moore
BACKGROUND: The insertion of external ventricular drains (EVDs) is necessary in some neurosurgical patients, but increases the risk of meningitis/ventriculitis. While there are well-recognized risk factors, the proportion of patients who develop meningitis/ventriculitis varies partly due to differences in definitions. A multi-disciplinary working group was established to agree definitions for EVD-associated meningitis/ventriculitis, and a surveillance system was piloted in four centres in the UK and Ireland...
September 17, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27751614/rates-of-iatrogenic-ventriculitis-before-and-after-the-use-of-an-alcohol-impregnated-external-ventricular-drain-port-cap
#17
Zachary D Levy, David E Ledoux, Martin L Lesser, Timothy White, Jaclyn M Rosenthal, Marguerite Johnson, Gunes A Aygok
Iatrogenic ventriculitis is a potential complication of ventriculostomy drain placement. In this study, an alcohol-impregnated external ventricular drain port cap was added to a standardized ventriculostomy placement bundle. Rates of ventriculitis were reduced postintervention, but this finding did not reach statistical significance.
October 14, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27727033/a-rare-central-nervous-system-fungal-infection-resulting-from-brown-heroin-use
#18
Eric M Melnychuk, David P Sole
BACKGROUND: Fungal nervous system infection can be a difficult diagnosis to make, due to the fact that there are no specific manifestations of the disease and laboratory confirmation is difficult to confirm. CASE REPORT: We report a young male who presented to our emergency department with a variety of unilateral visual field complaints. While he initially denied recent IV drug abuse, his physical examination was highly suggestive of a fungal infection known to result from brown heroin use...
October 8, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27695542/intracranial-abscesses-retrospective-analysis-of-32-patients-and-review-of-literature
#19
David O Udoh, Emmanuel Ibadin, Mojisola O Udoh
BACKGROUND: Intracranial abscess collections, though uncommon, are dreaded complications of head trauma, neurosurgical operations, meningitis, and otogenic, mastoid, and paranasal air sinus infections. Combining surgical evacuation with the appropriate antibiotic therapy is the effective treatment for intracranial abscesses. However, literature on surgical treatment is replete with several procedures which, on their own, may not. OBJECTIVES: To determine the epidemiology and outcomes (of various treatment modalities) of intracranial abscesses in our institution, a major referral center for neurosurgical conditions in the midwestern region of Nigeria...
October 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27680967/ventriculitis-and-multicompartmental-hydrocephalus-a-new-endoscopic-goal
#20
Marianna Luongo, Umberto Godano
No abstract text is available yet for this article.
September 28, 2016: Journal of Neurosurgical Sciences
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