Read by QxMD icon Read


Ute Blassmann, Anka C Roehr, Otto R Frey, Cornelia Vetter-Kerkhoff, Niklas Thon, William Hope, Josef Briegel, Volker Huge
BACKGROUND: Ventriculitis is a complication of temporary intraventricular drains. The limited penetration of meropenem into the cerebrospinal fluid (CSF) is well known. However, ventricular CSF pharmacokinetic data in patients with ventriculitis are lacking. The aim of this study was to evaluate meropenem pharmacokinetics in the serum and CSF of neurocritical care patients with proven or suspected ventriculitis. METHODS: We conducted an observational pharmacokinetic study of neurocritical care patients with proven or suspected ventriculitis receiving meropenem...
October 24, 2016: Critical Care: the Official Journal of the Critical Care Forum
H Humphreys, P Jenks, J Wilson, V Weston, R Bayston, C Waterhouse, A Moore
BACKGROUND: The insertion of external ventricular drains (EVDs) is necessary in some neurosurgical patients, but increases the risk of meningitis/ventriculitis. While there are well-recognized risk factors, the proportion of patients who develop meningitis/ventriculitis varies partly due to differences in definitions. A multi-disciplinary working group was established to agree definitions for EVD-associated meningitis/ventriculitis, and a surveillance system was piloted in four centres in the UK and Ireland...
September 17, 2016: Journal of Hospital Infection
Zachary D Levy, David E Ledoux, Martin L Lesser, Timothy White, Jaclyn M Rosenthal, Marguerite Johnson, Gunes A Aygok
Iatrogenic ventriculitis is a potential complication of ventriculostomy drain placement. In this study, an alcohol-impregnated external ventricular drain port cap was added to a standardized ventriculostomy placement bundle. Rates of ventriculitis were reduced postintervention, but this finding did not reach statistical significance.
October 14, 2016: American Journal of Infection Control
Eric M Melnychuk, David P Sole
BACKGROUND: Fungal nervous system infection can be a difficult diagnosis to make, due to the fact that there are no specific manifestations of the disease and laboratory confirmation is difficult to confirm. CASE REPORT: We report a young male who presented to our emergency department with a variety of unilateral visual field complaints. While he initially denied recent IV drug abuse, his physical examination was highly suggestive of a fungal infection known to result from brown heroin use...
October 8, 2016: Journal of Emergency Medicine
David O Udoh, Emmanuel Ibadin, Mojisola O Udoh
BACKGROUND: Intracranial abscess collections, though uncommon, are dreaded complications of head trauma, neurosurgical operations, meningitis, and otogenic, mastoid, and paranasal air sinus infections. Combining surgical evacuation with the appropriate antibiotic therapy is the effective treatment for intracranial abscesses. However, literature on surgical treatment is replete with several procedures which, on their own, may not. OBJECTIVES: To determine the epidemiology and outcomes (of various treatment modalities) of intracranial abscesses in our institution, a major referral center for neurosurgical conditions in the midwestern region of Nigeria...
October 2016: Asian Journal of Neurosurgery
Marianna Luongo, Umberto Godano
No abstract text is available yet for this article.
September 28, 2016: Journal of Neurosurgical Sciences
Nora Elfiky, Kelly Baldwin
Chronic meningitis and ventriculitis are defined as inflammatory pleocytoses in the cerebrospinal fluid (CSF) and ependyma that persists for at least 1 month without spontaneous resolution. Because the CSF communicates directly with the posterior compartments of the eye, fungal infections in the brain often cause secondary ophthalmologic complications. We report a 23-year-old male who presented to the emergency room with progressive severe headaches associated with insidious monocular vision loss. After extensive workup and a multidisciplinary team effort, the patient was diagnosed with ventriculitis and endogenous endopthalmitis...
May 2016: Case Reports in Neurology
Tulin Demir, Selcuk Kilic
Zika virus (ZIKV) is a single-stranded RNA virus in the Flaviviridae family and transmitted to human through infected mosquitos (Aedes aegypti and Aedes albopictus). Virus is closely related with other flaviviruses; dengue virus, yellow fever virus, West Nile virus, and Japanese encephalitis virus phylogenetically. Due to the possible relationship between virus and clinical features including microcephaly, ventricule, and eye deformities, Guillain-Barre syndrome increases the interest on this virus gradually...
November 2016: Folia Microbiologica
Chanunya Srihawan, Rodrigo Lopez Castelblanco, Lucrecia Salazar, Susan H Wootton, Elizabeth Aguilera, Luis Ostrosky-Zeichner, David I Sandberg, HuiMahn A Choi, Kiwon Lee, Ryan Kitigawa, Nitin Tandon, Rodrigo Hasbun
Background.  Healthcare-associated meningitis or ventriculitis is a serious and life-threatening complication of invasive neurosurgical procedures or penetrating head trauma. Methods.  We performed a retrospective study of adults and children with the diagnosis of healthcare-associated meningitis or ventriculitis, as defined by the 2015 Centers of Disease Control and Prevention case definition, at 2 large tertiary care hospitals in Houston, Texas from July 2003 to November 2014. Patients were identified by infection control practitioners and by screening cerebrospinal fluid samples sent to the central laboratory...
April 2016: Open Forum Infectious Diseases
Bodiabaduge A P Jayasekera, Julie Hall, Simon Pearce, Alistair J Jenkins
We report the case of a 70-year-old man presenting with pituitary apoplexy from a macroprolactinoma and ventriculitis. It was not possible to distinguish a bacterial or chemical origin, on the basis of his clinical presentation, laboratory studies and imaging, highlighting the importance of prompt imaging and attainment of CSF cultures, in making the diagnosis.
July 11, 2016: British Journal of Neurosurgery
Jason W Signorelli, Joshua W Osbun, Eric J Arias, Lauren C Reynolds, Douglas Chyatte, Matthew R Reynolds
Self-injection of household cleaning detergents (more specifically, commercial toilet bowl cleaner) into the reservoir of a ventriculoperitoneal shunt (VPS) has never been reported in the neurosurgical literature. A right-handed 41-year-old female with a past medical history significant for bipolar depression (with multiple prior hospital admissions for suicide attempts) and pseudotumor cerebri (status-post VPS placement from a right frontal approach) successfully injected ∼5 ml of toilet bowl cleaner into her ventricular shunt reservoir during a suicide attempt...
September 2016: Acta Neurochirurgica
Babak Ganjeifar, Samira Zabihyan, Humain Baharvahdat, Aslan Baradaran
No abstract text is available yet for this article.
October 2016: British Journal of Neurosurgery
Takumi Chikuba, Haru Uehara, Shintaro Fumikura, Ken Takahashi, Yoshihisa Suzuki, Kaori Hoshinoo, Yu Yamamoto
The outbreak of Riemerella anatipestifer (RA) infection has been confirmed in meat-type domestic ducks (Anas platyrhynchos) for the first time in 27 years in Japan. In January 2014, increased mortality in a 14- to 21-day-old duck flock was reported to veterinary officials by the owner. The affected ducks exhibited reduced movement, ataxia and dorsal recumbency with leg paddling. Pathological findings were typical for an RA infection. Fibrinous and heterophilic pericarditis, airsacculitis, perihepatitis, ventriculitis and meningitis were observed...
July 2, 2016: Journal of Veterinary Medical Science
Elisabetta Schiaroli, Maria Bruna Pasticci, Elena De Carolis, Enrica Mello, Carlo Pallotto, Christian Leli, Giuseppe Vittorio De Socio, Franco Baldelli, Maurizio Sanguinetti, Antonella Mencacci
Infections by Nocardia spp. are generally regarded as opportunistic diseases in immunocompromised patients, but can also affect immunocompetent subjects. Such infections represent an important diagnostic challenge for clinicians and microbiologists, and diagnosis is frequently delayed or even conducted post mortem. A 54-year-old man was admitted to our hospital because of ventriculitis and relapsing brain abscess. Five months prior, this patient had undergone external ventricular drain and surgery for a cerebellar abscess...
June 1, 2016: Le Infezioni in Medicina
Gentle Sunder Shrestha, Sushil Tamang, Hem Raj Paneru, Pramesh Sunder Shrestha, Niraj Keyal, Subhash Prasad Acharya, Moda Nath Marhatta, Sushil Shilpakar
Acinetobacter baumannii is an important cause of nosocomial ventriculitis associated with external ventricular device (EVD). It is frequently multidrug resistant (MDR), carries a poor outcome, and is difficult to treat. We report a case of MDR Acinetobacter ventriculitis treated with intravenous and intraventricular colistin together with intravenous tigecycline. The patient developed nephrotoxicity and poor neurological outcome despite microbiological cure. Careful implementation of bundle of measures to minimize EVD-associated ventriculitis is valuable...
July 2016: Journal of Neurosciences in Rural Practice
K J Helton, G Maron, E Mamcarz, V Leventaki, Z Patay, Z Sadighi
No abstract text is available yet for this article.
June 27, 2016: Bone Marrow Transplantation
Lars F Westblade, Eileen M Burd
No abstract text is available yet for this article.
July 2016: Journal of Clinical Microbiology
Lars F Westblade, Eileen M Burd
No abstract text is available yet for this article.
July 2016: Journal of Clinical Microbiology
Amandeep Kumar, Deepak Agrawal, Bhawani S Sharma
INTRODUCTION: Ventriculitis is a serious infection associated with high mortality even when both intravenous (IV) and intrathecal (IT) antibiotics are administered. Poor outcome in patients with ventriculitis indicates the need to be more aggressive in our attempts to expeditiously eradicate the infection. The purpose of this study was to evaluate the role of endoscopic lavage (EL) in patients with severe purulent ventriculitis, unresponsive to IV and IT antibiotics. METHODS: All consecutive patients with severe ventriculitis caused by multidrug-resistant gram-negative bacteria, undergoing EL after failure of prolonged courses of IV and IT antibiotics, were included in the study...
September 2016: World Neurosurgery
Christoph Drenckhahn, Claudia Windler, Sebastian Major, Eun-Jeung Kang, Michael Scheel, Peter Vajkoczy, Jed A Hartings, Johannes Woitzik, Jens P Dreier
PURPOSE: Patients with aneurysmal subarachnoid hemorrhage (aSAH) frequently develop secondary noninfectious and infectious complications with an important impact on clinical course and outcome. In this study, we report on the rate of typical extracranial and intracranial complications in 30 prospectively enrolled patients with severe aSAH who received a linear subdural recording strip for continuous electrocorticography to detect ictal epileptiform events and spreading depolarizations...
June 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"