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https://www.readbyqxmd.com/read/29457841/erectile-dysfunction-they-don-t-talk-we-don-t-ask
#1
A Rakovac Tisdall, T F J King, W A W Mahmood, C S Keat, R Ali, R Abdin, C M Koo, M Alali, S Sreenan, J H McDermott
Erectile dysfunction is an under-reported complication of diabetes mellitus affecting over half of male patients [1]. Although many men with diabetes consider that erectile dysfunction has a negative influence on their quality of life, they are reluctant to report it; and while most would like treatment, they prefer physicians to start the conversation [2-4]. Erectile dysfunction predicts future cardiovascular disease, and screening for erectile dysfunction is advocated in several cardiovascular risk assessment algorithms [5]...
February 19, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29457225/aperture-generation-based-on-threshold-segmentation-for-intensity-modulated-radiotherapy-treatment-planning
#2
Jie Yang, Zhiguo Gui, Liyuan Zhang, Pengcheng Zhang
PURPOSE: To reduce computation and decrease planning time with little or no loss in plan quality compared to the column-generation-based (cg) method, a simple method of aperture generation based on threshold segmentation (agts) is proposed. METHODS: The proposed agts strategy consists of two steps. First, a fuzzy controller is used for noise cancellation; then, new apertures are added using the threshold segmentation algorithm. We tested the proposed method on seven prostate tumor cases using the computational environment for radiotherapy research algorithms for the dose calculations and compared the results with those obtained by generating the plan aperture using the cg method...
February 19, 2018: Medical Physics
https://www.readbyqxmd.com/read/29457209/agreement-between-integrated-management-of-childhood-illness-and-final-diagnosis-in-acute-respiratory-tract-infections
#3
Sıddika Songül Yalçın, Beril Özdemir, Sadriye Özdemir, Esra Baskın
OBJECTIVE: To evaluate the agreement between integrated management of childhood illness (IMCI) and final diagnosis in patients presenting with cough at the second and third level health institutions. METHODS: This cross-sectional study included 373 children aged 2-60 mo who presented with cough at the pediatric emergency and outpatient clinics in the Department of Pediatrics. After clinical examination of children, body temperature, respiratory rate, saturation, presence or absence of the chest indrawing, rales, wheezing and laryngeal stridor were recorded...
February 19, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29456922/propensity-scores-in-pharmacoepidemiology-beyond-the-horizon
#4
John W Jackson, Ian Schmid, Elizabeth A Stuart
Purpose of review: Propensity score methods have become commonplace in pharmacoepidemiology over the past decade. Their adoption has confronted formidable obstacles that arise from pharmacoepidemiology's reliance on large healthcare databases of considerable heterogeneity and complexity. These include identifying clinically meaningful samples, defining treatment comparisons, and measuring covariates in ways that respect sound epidemiologic study design. Additional complexities involve correctly modeling treatment decisions in the face of variation in healthcare practice, and dealing with missing information and unmeasured confounding...
December 2017: Current Epidemiology Reports
https://www.readbyqxmd.com/read/29456917/neuromonitoring-in-spinal-deformity-surgery-a-multimodality-approach
#5
REVIEW
Joseph L Laratta, Alex Ha, Jamal N Shillingford, Melvin C Makhni, Joseph M Lombardi, Earl Thuet, Ronald A Lehman, Lawrence G Lenke
Study Design: Literature review. Objective: The aim of this study was to provide an overview of the available intraoperative monitoring techniques and the evidence around their efficacy in vertebral column resection. Methods: The history of neuromonitoring and evolution of the modalities are reviewed and discussed. The authors' specific surgical techniques and preferred methods are outlined in detail. In addition, the authors' experience and the literature regarding vertebral column resection and surgical mitigation of neurologic alarms are discussed at length...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456913/investigating-the-7-year-cost-effectiveness-of-single-level-cervical-disc-replacement-compared-to-anterior-cervical-discectomy-and-fusion
#6
Steven J McAnany, Robert K Merrill, Samuel C Overley, Jun S Kim, Robert L Brochin, Sheeraz A Qureshi
Study Design: Cost-effectiveness analysis. Objectives: To determine the 7-year cost-effectiveness of cervical disc replacement (CDR) and anterior cervical discectomy and fusion (ACDF). Methods: We analyzed 7-year Short Form-36 Health Survey data collected from the Prestige Cervical Disc investigational device exemption study (IDE). The SF-6D algorithm was used to convert this data into health state utilities. Costs were calculated from the payer perspective, and quality adjusted life years (QALYs) were used to represent effectiveness...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456286/examining-thematic-similarity-difference-and-membership-in-three-online-mental-health-communities-from-reddit-a-text-mining-and-visualization-approach
#7
Albert Park, Mike Conway, Annie T Chen
Objectives: Social media, including online health communities, have become popular platforms for individuals to discuss health challenges and exchange social support with others. These platforms can provide support for individuals who are concerned about social stigma and discrimination associated with their illness. Although mental health conditions can share similar symptoms and even co-occur, the extent to which discussion topics in online mental health communities are similar, different, or overlapping is unknown...
January 2018: Computers in Human Behavior
https://www.readbyqxmd.com/read/29455350/analysing-the-accuracy-of-machine-learning-techniques-to-develop-an-integrated-influent-time-series-model-case-study-of-a-sewage-treatment-plant-malaysia
#8
Mozafar Ansari, Faridah Othman, Taher Abunama, Ahmed El-Shafie
The function of a sewage treatment plant is to treat the sewage to acceptable standards before being discharged into the receiving waters. To design and operate such plants, it is necessary to measure and predict the influent flow rate. In this research, the influent flow rate of a sewage treatment plant (STP) was modelled and predicted by autoregressive integrated moving average (ARIMA), nonlinear autoregressive network (NAR) and support vector machine (SVM) regression time series algorithms. To evaluate the models' accuracy, the root mean square error (RMSE) and coefficient of determination (R2 ) were calculated as initial assessment measures, while relative error (RE), peak flow criterion (PFC) and low flow criterion (LFC) were calculated as final evaluation measures to demonstrate the detailed accuracy of the selected models...
February 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29455255/fasting-or-non-fasting-lipids-for-atherosclerotic-cardiovascular-disease-risk-assessment-and-treatment
#9
REVIEW
Faisal Rahman, Roger S Blumenthal, Steven R Jones, Seth S Martin, Tyler J Gluckman, Seamus P Whelton
PURPOSE OF REVIEW: Dyslipidemia is a major modifiable risk factor for atherosclerotic cardiovascular disease (ASCVD); however, lipid testing for risk assessment and treatment surveillance has been underutilized. Several factors likely account for this, including the common practice of measuring lipid levels in the fasting state, which often necessitates that patients return for an additional visit. In this review, we evaluate potential advantages and cautions associated with measuring lipids in the non-fasting state...
February 17, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29454659/predicting-visual-acuity-by-using-machine-learning-in-patients-treated-for-neovascular-age-related-macular-degeneration
#10
Markus Rohm, Volker Tresp, Michael Müller, Christoph Kern, Ilja Manakov, Maximilian Weiss, Dawn A Sim, Siegfried Priglinger, Pearse A Keane, Karsten Kortuem
PURPOSE: To predict, by using machine learning, visual acuity (VA) at 3 and 12 months in patients with neovascular age-related macular degeneration (AMD) after initial upload of 3 anti-vascular endothelial growth factor (VEGF) injections. DESIGN: Database study. PARTICIPANTS: For the 3-month VA forecast, 653 patients (379 female) with 738 eyes and an average age of 74.1 years were included. The baseline VA before the first injection was 0...
February 14, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29454557/development-of-a-risk-scoring-system-to-evaluate-the-serosal-invasion-for-macroscopic-serosal-invasion-positive-gastric-cancer-patients
#11
Peng-Liang Wang, Jin-Yu Huang, Zhi Zhu, Bao-Cheng Gong, Han-Wei Huang, Shi-Jie Duan, Hui-Mian Xu, Fu-Nan Liu
BACKGROUND: The status of serosal invasion is often discordance between pathological and intraoperative evaluation. Our study sought to develop a risk-scoring system (RSS) to predict the probability of pT4a for macroscopic serosal invasion (MSI) positive patients and reevaluate the serosal invasion status. PATIENTS AND METHODS: A total of 1301 pT3/pT4a gastric cancer patients with curative surgery were reviewed. We constructed the RSS to predict the probability of pT4a and assigned MSI-positive patients into different risk groups based on the risk scores...
February 3, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29454493/updating-the-recommendations-for-treatment-of-tardive-syndromes-a-systematic-review-of-new-evidence-and-practical-treatment-algorithm
#12
REVIEW
Roongroj Bhidayasiri, Onanong Jitkritsadakul, Joseph H Friedman, Stanley Fahn
BACKGROUND: Management of tardive syndromes (TS) is challenging, with only a few evidence-based therapeutic algorithms reported in the American Academy of Neurology (AAN) guideline in 2013. OBJECTIVE: To update the evidence-based recommendations and provide a practical treatment algorithm for management of TS by addressing 5 questions: 1) Is withdrawal of dopamine receptor blocking agents (DRBAs) an effective TS treatment? 2) Does switching from typical to atypical DRBAs reduce TS symptoms? 3) What is the efficacy of pharmacologic agents in treating TS? 4) Do patients with TS benefit from chemodenervation with botulinum toxin? 5) Do patients with TS benefit from surgical therapy? METHODS: Systematic reviews were conducted by searching PsycINFO, Ovid MEDLINE, PubMed, EMBASE, Web of Science and Cochrane for articles published between 2012 and 2017 to identify new evidence published after the 2013 AAN guidelines...
February 5, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29453243/peak-perihemorrhagic-edema-correlates-with-functional-outcome-in-intracerebral-hemorrhage
#13
Bastian Volbers, Antje Giede-Jeppe, Stefan T Gerner, Jochen A Sembill, Joji B Kuramatsu, Stefan Lang, Hannes Lücking, Dimitre Staykov, Hagen B Huttner
OBJECTIVE: To evaluate the association of perihemorrhagic edema (PHE) evolution and peak edema extent with day 90 functional outcome in patients with intracerebral hemorrhage (ICH) and identify pathophysiologic factors influencing edema evolution. METHODS: This retrospective cohort study included patients with spontaneous supratentorial ICH between January 2006 and January 2014. ICH and PHE volumes were studied using a validated semiautomatic volumetric algorithm...
February 16, 2018: Neurology
https://www.readbyqxmd.com/read/29452930/mechanism-specific-rehabilitation-management-of-complex-regional-pain-syndrome-proposed-recommendations-from-evidence-synthesis
#14
Tara Packham, Janet Holly
STUDY DESIGN: Narrative review. INTRODUCTION: There are a variety of treatments with demonstrated effectiveness for the management of complex regional pain syndrome (CRPS). However given the variability in symptom presentation in this population, therapists may be unsure what treatments would be most effective for individual clients. PURPOSE OF THE STUDY: To present a brief synthesis of the literature and propose a rehabilitation version of a mechanism-specific management algorithm to guide personalized treatment of CRPS...
February 13, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29452837/dramatically-polarized-opinion-on-the-role-of-brachytherapy-boost-in-management-of-high-risk-prostate-cancer-a-survey-of-north-american-genitourinary-expert-radiation-oncologists
#15
Shearwood McClelland, Kiri A Sandler, Catherine Degnin, Yiyi Chen, Timur Mitin
INTRODUCTION: Three randomized clinical trials have established brachytherapy (BT) boost in combination with external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT) as superior to definitive EBRT and ADT alone in terms of biochemical control (but not overall survival) at the expense of increased toxicity in men with high-risk (HR) prostate cancer (PCa). The current view regarding these 2 treatment algorithms among North American genitourinary (GU) experts is not known...
February 2, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29452298/treatment-and-outcomes-in-patients-with-igg4-related-disease-using-the-igg4-responder-index
#16
Andreu Fernández-Codina, Blanca Pinilla, Iago Pinal-Fernández, Cristina López, Guadalupe Fraile-Rodríguez, Eva Fonseca-Aizpuru, Iago Carballo, Pilar Brito-Zerón, Carlos Feijóo-Massó, Miguel López-Dupla, Maria Cinta Cid, Fernando Martínez-Valle
BACKGROUND: IgG4-related disease (IgG4-RD) is an autoimmune disease triggering an inflammatory cascade that leads to fibrosis. Outcome measures are limited and treatment options remain underexplored. OBJECTIVES: To assess the variation of the IgG4 responder index (IgG4-RI) in a cohort of IgG4-RD patients and to explore their treatments and outcomes. METHODS: We studied the clinical phenotype, severity of the disease and response to treatment in an ambispective multicenter cohort study including 14 different hospitals in Spain...
February 13, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29451938/the-management-of-cerebrospinal-fluid-leak-after-anterior-cervical-decompression-surgery
#17
Jiliang Zhai, Ripul R Panchal, Ye Tian, Shujie Wang, Lijuan Zhao
Cerebrospinal fluid (CSF) leak is a rare but potentially troublesome and occasionally catastrophic complication after anterior cervical decompression surgery. There is limited literature describing this complication, and the management of CSF leak varies. The aim of this study was to retrospectively review the treatment of cases with CSF leak and develop a management algorithm. A series of 14 patients with CSF leak from January 2011 to May 2016 were included in this study. Their characteristics, management of CSF leak, and outcomes were documented...
February 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29451045/modified-release-paracetamol-overdose-a-prospective-observational-study-atom-3
#18
Angela L Chiew, Geoffrey K Isbister, Colin B Page, Katharine A Kirby, Betty S H Chan, Nicholas A Buckley
BACKGROUND: Modified-release (MR) paracetamol is available in many countries as 665 mg tablets of which 69% is MR and 31% is immediate release. There are concerns that MR paracetamol overdose has higher rates of liver injury despite standard treatment algorithms. The objective of this study was to describe the clinical characteristics and outcomes of acute MR paracetamol overdose. METHODS: Prospective observational study, recruiting patients from January 2013 to June 2017, from five clinical toxicology units and calls to two Poisons Information Centres in Australia...
February 16, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29451016/evaluation-of-a-new-noninvasive-glucose-monitoring-device-by-means-of-standardized-meal-experiments
#19
Andreas Pfützner, Stephanie Strobl, Filiz Demircik, Lisa Redert, Johannes Pfützner, Anke H Pfützner, Alexander Lier
BACKGROUND: Frequent blood glucose readings are the most cumbersome aspect of diabetes treatment for many patients. The noninvasive TensorTip Combo Glucometer (CoG) component employs dedicated mathematical algorithms to analyze the collected signal and to predict tissue glucose at the fingertip. This study presents the performance of the CoG (the invasive and the noninvasive components) during a standardized meal experiment. METHODS: Each of the 36 participants (18 females and males each, age: 49 ± 18 years, 14 healthy subjects, 6 type 1 and 16 type 2 patients) received a device for conducting calibration at home...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29450843/detection-of-lung-contour-with-closed-principal-curve-and-machine-learning
#20
Tao Peng, Yihuai Wang, Thomas Canhao Xu, Lianmin Shi, Jianwu Jiang, Shilang Zhu
Radiation therapy plays an essential role in the treatment of cancer. In radiation therapy, the ideal radiation doses are delivered to the observed tumor while not affecting neighboring normal tissues. In three-dimensional computed tomography (3D-CT) scans, the contours of tumors and organs-at-risk (OARs) are often manually delineated by radiologists. The task is complicated and time-consuming, and the manually delineated results will be variable from different radiologists. We propose a semi-supervised contour detection algorithm, which firstly uses a few points of region of interest (ROI) as an approximate initialization...
February 15, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
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