Read by QxMD icon Read

Treatment algorithm

A A Fokin, K A Kireev
The purpose of the study was to elaborate an algorithm of treatment policy for post-puncture false aneurysms of the femoral artery (FAFA). The study was performed on the basis of the clinical material over 2014-2017 at the Regional Vascular Centre whose specialists have since 2017 been using the femoral arterial approach (FAA) only if the radial arteries are inaccessible for puncture or for inserting the endovascular tools and appliances. The obtained findings demonstrated that the number of coronary interventions performed with the use of the femoral arterial approach in patients presenting with acute coronary syndrome decreased from a total of 758 (100...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Kyle Hobbs, Prashanth Krishnamohan, Catherine Legault, Steve Goodman, Josef Parvizi, Kapil Gururangan, Michael Mlynash
BACKGROUND: Patients suffering from non-convulsive seizures experience delays in diagnosis and treatment due to limitations in acquiring and interpreting electroencephalography (EEG) data. The Ceribell EEG System offers rapid EEG acquisition and conversion of EEG signals to sound (sonification) using a proprietary algorithm. This study was designed to test the performance of this EEG system in an intensive care unit (ICU) setting and measure its impact on clinician treatment decision...
June 19, 2018: Neurocritical Care
Prashanth Rawla, Tagore Sunkara, Krishna Chaitanya Thandra, Vinaya Gaduputi
Hypertriglyceridemia (HTG) is an uncommon but well-established cause of acute pancreatitis (AP) comprising up to 7% of the cases. The clinical course of HTG-induced pancreatitis (HTGP) is highly similar to that of AP of other etiologies with HTG being the only distinguishing clinical feature. However, HTGP is often correlated with higher severity and elevated complication rate. At present, no approved treatment guideline for the management of HTGP is available, although different treatment modalities such as insulin, heparin, fibric acids, and omega 3 fatty acids have been successfully implemented to reduce serum triglycerides (TG)...
June 19, 2018: Clinical Journal of Gastroenterology
Fabian Henry Jürgen Elsholtz, Lars-Arne Schaafs, Christoph Erxleben, Bernd Hamm, Stefan Markus Niehues
PURPOSE: Computed tomography (CT)-guided periradicular infiltration therapy has emerged as an effective treatment option for patients with low back pain. Concern about radiation exposure requires approaches allowing significant dose reduction. The purpose of this study is to evaluate the need for iterative reconstruction software in CT-guided periradicular infiltration therapy with an ultra-low-dose protocol. MATERIALS AND METHODS: One hundred patients underwent CT-guided periradicular infiltration therapy of the lumbar spine using an ultra-low-dose protocol with adaptive iterative dose reduction 3D (AIDR 3D) for image reconstruction...
June 19, 2018: La Radiologia Medica
Daniël M C Janssen, Maud Kramer, Jan Geurts, Lodewijk V Rhijn, Geert H I M Walenkamp, Paul C Willems
Background: There is no generally established treatment algorithm for the management of surgical site infection (SSI) and non-union after instrumented spinal surgery. In contrast to infected hip- and knee- arthroplasties, the use of a local gentamicin impregnated carrier in spinal surgery has not been widely reported in literature. Patients and methods: We studied 48 deep SSI and non-union patients after instrumented spine surgery, treated between 1999 and 2016. The minimum follow-up was 1.5 years. All infections were treated with a treatment-regimen consisting of systemic antibiotics and repetitive surgical debridement, supplemented with local gentamicin releasing carriers...
2018: Journal of Bone and Joint Infection
Guirong Wang, Weijie Dong, Tinglong Lan, Jun Fan, Kai Tang, Yuan Li, Guangxuan Yan, Guanglu Jiang, Yifeng Ma, Yuanyuan Shang, Shibing Qin, Hairong Huang
Early diagnosis of spinal tuberculosis (TB) is hampered by the flaws of conventional tests. The aim of this study was to assess the value of new and existing molecular tests in a prospective, head-to-head cohort study. Specimens were consecutively collected from spinal TB suspects in four hospitals in Beijing, China. Smear, culture, histopathology, Xpert MTB/RIF (Xpert), and MeltPro TB assays were performed in parallel using the same specimen from each patient. Drug-susceptibility testing (DST) was conducted on the isolates recovered...
June 20, 2018: Emerging Microbes & Infections
Bo Cao, Raymond Y Cho, Dachun Chen, Meihong Xiu, Li Wang, Jair C Soares, Xiang Yang Zhang
Identifying biomarkers in schizophrenia during the first episode without the confounding effects of treatment has been challenging. Leveraging these biomarkers to establish diagnosis and make individualized predictions of future treatment responses to antipsychotics would be of great value, but there has been limited progress. In this study, by using machine learning algorithms and the functional connections of the superior temporal cortex, we successfully identified the first-episode drug-naive (FEDN) schizophrenia patients (accuracy 78...
June 19, 2018: Molecular Psychiatry
Barbara Strobino, Katja Steinhagen, Wolfgang Meyer, Thomas Scheper, Sandra Saschenbrecker, Wolfgang Schlumberger, Winfried Stöcker, Andrea Gaito, Brian A Fallon
The objective was to examine the prevalence of Borrelia antibodies among symptomatic individuals with recent and past Lyme disease in endemic communities using standard assays and novel assays employing next-generation antigenic substrates. Single- and two-tiered algorithms included different anti- Borrelia ELISAs and immunoblots. Antibody prevalence was examined in sera from 32 individuals with recent erythema migrans (EM), 335 individuals with persistent symptoms following treatment for Lyme disease (PTLS), and 41 community controls without a history of Lyme disease...
June 19, 2018: Healthcare (Basel, Switzerland)
Rebecca Fish, Andrew G Renehan, Grant Punnett, Omer Aziz, Paul Fulford, Chelliah Selvasekar, Malcolm Wilson, Rebecca Halstead, Sarah T O'Dwyer
AIM: Pseudomyxoma peritonei (PMP) is a rare neoplasm of the appendix, which if untreated disseminates throughout the abdominal cavity and generates considerable morbidity. Since 2002 in the UK, patients with PMP have been managed via two nationally commissioned centres. We evaluated referrals and treatment pathways over time at the Manchester centre. METHOD: Data from all patients referred with suspected PMP were prospectively collected (2002-2015). Definitive treatment was cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC)...
June 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Kailynn J DeRonde, Jennifer E Girotto, David P Nicolau
Acute hematogenous osteomyelitis (AHO), often occurring in young children, is the most frequently diagnosed type of osteomyelitis in pediatric patients. Optimizing antibiotics is essential as delays to receipt of appropriate therapy can lead to chronic osteomyelitis, as well as impairments in bone growth and development. Antimicrobial Stewardship Programs (ASPs) are in a key position to help improve the care of patients with AHO as they contain a pharmacist with expertise in antibiotic drug selection, optimization of dosing, and microbiologic test review...
June 19, 2018: Pharmacotherapy
P J Tozer, P Lung, A J Lobo, S Sebastian, S R Brown, A L Hart, N Fearnhead
BACKGROUND: Evidence from groups who have studied fistula aetiology and extrapolation from interventional studies supports a multifactorial hypothesis of Crohn's perianal fistula, with several pathophysiological elements that may contribute to fistula formation, persistence and resistance to treatment. AIM: An evidence synthesis of current understanding of pathophysiological factors underlying Crohn's perianal fistula is presented, exploring the fundamental reasons why some treatments succeed and others fail, as a means of focussing clinical knowledge on improving treatment of Crohn's perianal fistula...
June 19, 2018: Alimentary Pharmacology & Therapeutics
Mira Park, Soon Gyu Hong, Hyun Park, Byeong-Ha Lee, Hyoungseok Lee
Sanionia uncinata is a dominant moss species in the maritime Antarctic. Due to its high adaptability to harsh environments, this extremophile plant has been considered a good target for studying the molecular adaptation mechanisms of plants to a variety of environmental stresses. Despite the importance of S. uncinata as a representative Antarctic plant species for the identification and characterization of genes associated with abiotic stress tolerance, suitable reference genes, which are critical for RT-qPCR analyses, have not yet been identified...
2018: PloS One
Rahim Alhamzawi, Haithem Taha Mohammad Ali
Classical adaptive lasso regression is known to possess the oracle properties; namely, it performs as well as if the correct submodel were known in advance. However, it requires consistent initial estimates of the regression coefficients, which are generally not available in high dimensional settings. In addition, none of the algorithms used to obtain the adaptive lasso estimators provide a valid measure of standard error. To overcome these drawbacks, some Bayesian approaches have been proposed to obtain the adaptive lasso and related estimators...
June 16, 2018: Mathematical Biosciences
Benjamin Leroy-Freschini, Giorgio Treglia, Xavier Argemi, Caroline Bund, Romain Kessler, Raoul Herbrecht, Alessio Imperiale
Background: Opportunistic invasive fungal infections (IFIs) comprise a heterogeneous spectrum of pathogens, whose early diagnosis remains challenging. Candida spp. and Aspergillus spp, the most frequent pathogens in immunocompromised patients, frequently affect lungs, liver, bone and skin. Aim: To evaluate the impact of 18F-FDG PET/CT in the management of immunocompromised patients with IFI. Design: A single-center retrospective study included 51 immunocompromised patients with IFI diagnosis undergoing 83 18F-FDG PET/CTs...
June 18, 2018: QJM: Monthly Journal of the Association of Physicians
Nicole G Campos, Naomi Lince-Deroche, Carla J Chibwesha, Cynthia Firnhaber, Jennifer S Smith, Pam Michelow, Gesine Meyer-Rath, Lise Jamieson, Suzette Jordaan, Monisha Sharma, Catherine Regan, Stephen Sy, Gui Liu, Vivien Tsu, Jose Jeronimo, Jane J Kim
BACKGROUND: Women with HIV face an increased risk of human papillomavirus (HPV) acquisition and persistence, cervical intraepithelial neoplasia, and invasive cervical cancer. Our objective was to determine the cost-effectiveness of different cervical cancer screening strategies among women with HIV in South Africa. METHODS: We modified a mathematical model of HPV infection and cervical disease to reflect co-infection with HIV. The model was calibrated to epidemiologic data from HIV-infected women in South Africa...
June 15, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Bayard C Carlson, Nicholas M Desy, Joshua D Johnson, Robert T Trousdale, Michael Leunig, Reinhold Ganz, Rafael J Sierra
BACKGROUND: Redislocation of the native hip is rare. An anterior fulcrum between the proximal part of the femur and the pelvis must be present for a posterior dislocation to occur. The purpose of this study is to describe the cases of 9 patients with posterior redislocation or recurrent subluxation of the native hip that was treated with hip preservation surgery. METHODS: We retrospectively identified the cases of 9 patients, from 2 institutions, who had undergone hip preservation surgery for the management of posterior redislocation or recurrent subluxation of the native hip after a dislocation...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
Akash A Shah, Paul T Ogink, Mitchel B Harris, Joseph H Schwab
BACKGROUND: Spinal epidural abscess is a high-risk condition that can lead to paralysis or death. It would be of clinical and prognostic utility to identify which subset of patients with spinal epidural abscess is likely to develop a motor deficit or die within 90 days of discharge. METHODS: We identified all patients ≥18 years of age who were admitted to our hospital system with a diagnosis of spinal epidural abscess during the period of 1993 to 2016. Explanatory variables were collected retrospectively...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
Ulrich E Ziegler, Udo Lorenz, Adrien Daigeler, Selina N Ziegler, Philip H Zeplin
BACKGROUND: Pseudogynecomastia is the increased aggregation of fatty tissue in the area of the male breast with resultant female appearance. Two forms can appear: pseudogynecomastia after massive weight loss (pseudogynecomastia obese [PO]) and pseudogynecomastia, which is caused only by adipose tissue (pseudogynecomastia fat). For PO, only the Gusenoff classification with corresponding operative treatment options exists. However, this classification is limited by the fact that it underestimates the extensive variability of residual fat tissue and skin excess, both crucial factors for operative planning...
June 19, 2018: Annals of Plastic Surgery
Carolina Vázquez, María Orlova, Paula Scibona, Bruno L Ferreyro, Victoria Otero, Esteban G Jáuregui, Jorge Arbelbide, Waldo H Belloso
: Coumadin oral anticoagulants are widely used in multiple clinical scenarios. Their narrow therapeutic range and a dosing strategy based on 'a posteriori' algorithms, pose them as an interesting group for prediction modelling research. Extensive literature explaining the association between clinical and genetic variables with the dose of warfarin have been published. Limited information exists regarding these factors and acenocoumarol dosing. The aim of the study is to explain through clinical/genetic variables, the weekly dose of acenocoumarol necessary for achieving stable anticoagulation status...
June 18, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Matheus Roque, Bianca Bianco, Denise M Christofolini, Emerson B Cordts, Fabia L Vilarino, Waldemar Carvalho, Marcello Valle, Marcos Sampaio, Selmo Geber, Sandro C Esteves, Caio P Barbosa
Controlled ovarian stimulation (COS) is crucial for optimizing in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) success. Multiple factors influence the ovarian response to COS, making predictions about oocyte yields not so straightforward. As a result, the ovarian response may be poor or suboptimal, or even excessive, all of which have negative consequences for the affected patient. There is a group of patients that present with a suboptimal response to COS despite normal biomarkers of ovarian reserve, such as AFC and AMH...
June 14, 2018: Panminerva Medica
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"