keyword
MENU ▼
Read by QxMD icon Read
search

New guideline

keyword
https://www.readbyqxmd.com/read/29679728/magnetic-resonance-imaging-of-the-lumbar-spine-determining-clinical-impact-and-potential-harm-from-overuse
#1
Nathan M Wnuk, Tarik K Alkasab, Daniel I Rosenthal
BACKGROUND: Lumbar spine MRI is frequently said to be "overused" in the evaluation of low-back pain, yet data concerning the extent of overuse and on potential harmful effects are lacking. PURPOSE: To determine the proportion of examinations with a detectable impact on patient care (actionable outcomes). STUDY DESIGN: Retrospective cohort study PATIENT SAMPLE: 5,365 outpatient lumbar spine MR examinations OUTCOME MEASURES: Actionable outcomes included: 1) findings leading to an intervention making use of anatomical information such as surgery; 2) new diagnoses of cancer, infection, or fracture; or 3) following known lumbar spine pathology...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679265/focus-groups-and-in-depth-interviews-to-guide-the-development-of-lung-cancer-screening-informational-materials
#2
Anushree Sharma, Richard O'Connor, Paula Celestino, Samantha Killion, Laurie Griswold-Krupski, Maansi Bansal-Travers
Lung cancer is one of the most lethal cancers in the USA. In 2013, new guidelines issued by the United States Preventive Services Task Force recommended lung cancer screening using low-dose computed tomography among a selected group of high-risk individuals. Specifically, lung cancer screening is recommended for heavy smokers between the ages of 55 to 79, with at least 30 pack-year smoking exposure. Former smokers who meet these guidelines and stopped smoking ≤ 15 years ago are also eligible. There is a need to promote lung cancer screening to increase early diagnosis rates and treatment options, thereby decreasing disease-specific mortality...
April 20, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29679141/ethical-considerations-of-researchers-conducting-pediatric-clinical-drug-trials-a-qualitative-survey-in-two-belgian-university-children-s-hospitals
#3
Wannes Van Hoof, Kevin Meesters, Lien Dossche, Daphné Christiaens, Pauline De Bruyne, Johan Vande Walle
There is a general consensus about the underlying theoretical ethical principles that ground the practice of pediatric clinical trials: scientific necessity, good risk/benefit ratio, minimized burden, and parental consent/child assent. However, these principles are so broadly construed that it is not always clear how they should be applied in clinical practice. We conducted a qualitative study at Ghent University Hospital and the hospital of the Dutch-speaking university of Brussels on how researchers weigh ethical principles, assess the risk/benefit balance, estimate patient experience, and experience informed consent procedures in pediatric drug studies...
April 21, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29678987/protocol-for-a-phase-iii-non-inferiority-randomised-comparison-of-a-new-fibrinogen-concentrate-versus-cryoprecipitate-for-treating-acquired-hypofibrinogenaemia-in-bleeding-cardiac-surgical-patients-the-fibres-trial
#4
Keyvan Karkouti, Jeannie Callum, Vivek Rao, Nancy Heddle, Michael E Farkouh, Mark A Crowther, Damon C Scales
INTRODUCTION: Coagulopathic bleeding is a serious complication of cardiac surgery to which an important contributor is acquired hypofibrinogenaemia (plasma fibrinogen <1.5-2.0 g/L). The standard intervention for acquired hypofibrinogenaemia is cryoprecipitate, but purified fibrinogen concentrates are also available. There is little comparative data between the two therapies and randomised trials are needed. METHODS AND ANALYSIS: FIBrinogen REplenishment in Surgery (FIBRES) is a multicentre, randomised (1:1), active-control, single-blinded, phase III trial in adult cardiac surgical patients experiencing clinically significant bleeding related to acquired hypofibrinogenaemia...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678866/gaps-in-guidelines-for-the-management-of-diabetes-in-low-and-middle-income-versus-high-income-countries-a-systematic-review
#5
REVIEW
Mayowa O Owolabi, Joseph O Yaria, Meena Daivadanam, Akintomiwa I Makanjuola, Gary Parker, Brian Oldenburg, Rajesh Vedanthan, Shane Norris, Ayodele R Oguntoye, Morenike A Osundina, Omarys Herasme, Sulaiman Lakoh, Luqman O Ogunjimi, Sarah E Abraham, Paul Olowoyo, Carolyn Jenkins, Wuwei Feng, Hernán Bayona, Sailesh Mohan, Rohina Joshi, Ruth Webster, Andre P Kengne, Antigona Trofor, Lucia Maria Lotrean, Devarsetty Praveen, Jessica H Zafra-Tanaka, Maria Lazo-Porras, Kirsten Bobrow, Michaela A Riddell, Konstantinos Makrilakis, Yannis Manios, Bruce Ovbiagele
OBJECTIVE: The extent to which diabetes (DM) practice guidelines, often based on evidence from high-income countries (HIC), can be implemented to improve outcomes in low- and middle-income countries (LMIC) is a critical challenge. We carried out a systematic review to compare type 2 DM guidelines in individual LMIC versus HIC over the past decade to identify aspects that could be improved to facilitate implementation. RESEARCH DESIGN AND METHODS: Eligible guidelines were sought from online databases and websites of diabetes associations and ministries of health...
May 2018: Diabetes Care
https://www.readbyqxmd.com/read/29678160/the-increasing-burden-and-complexity-of-multi-morbidity-and-polypharmacy-in-geriatric-hiv-patients-a-cross-sectional-study-of-people-aged-65-74-years-and-more-than-75-years
#6
G Guaraldi, A Malagoli, A Calcagno, C Mussi, B M Celesia, F Carli, S Piconi, G V De Socio, A M Cattelan, G Orofino, A Riva, E Focà, S Nozza, G Di Perri
BACKGROUND: Geriatric Patients Living with HIV/AIDS (GEPPO) is a new prospective observational multicentre cohort consisting of all the HIV-positive geriatric patients being treated at 10 clinics in Italy, and HIV-negative controls attending a single geriatric clinic. The aim of this analysis of the GEPPO cohort was to compare prevalence and risk factors of individual non-communicable diseases (NCD), multi-morbidity (MM) and polypharmacy (PP) amongst HIV positive and HIV negative controls at enrolment into the GEPPO cohort...
April 20, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29677310/who-issues-new-guidelines-for-ltbi
#7
M J Friedrich
No abstract text is available yet for this article.
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29677173/what-does-this-mutation-mean-the-tools-and-pitfalls-of-variant-interpretation-in-lymphoid-malignancies
#8
REVIEW
Guillermin Yann, Lopez Jonathan, Chabane Kaddour, Hayette Sandrine, Bardel Claire, Salles Gilles, Sujobert Pierre, Huet Sarah
High throughput sequencing (HTS) is increasingly important in determining cancer diagnoses, with subsequent prognostic and therapeutic implications. The biology of cancer is becoming increasingly deciphered and it is clear that therapy needs to be individually tailored. Whilst translational research plays an important role in lymphoid malignancies, few guidelines exist to guide biologists and routine laboratories through this constantly evolving field. In this article, we review the challenges of interpreting HTS in lymphoid malignancies and provide a toolkit to interpret single nucleotide variants obtained from HTS...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29677170/development-of-the-who-environmental-noise-guidelines-for-the-european-region-an-introduction
#9
Dorota Jarosińska, Marie-Ève Héroux, Poonum Wilkhu, James Creswick, Jos Verbeek, Jördis Wothge, Elizabet Paunović
Following the Parma Declaration on Environment and Health adopted at the Fifth Ministerial Conference (2010), the Ministers and representatives of Member States in the WHO European Region requested the World Health Organization (WHO) to develop updated guidelines on environmental noise, and called upon all stakeholders to reduce children's exposure to noise, including that from personal electronic devices. The WHO Environmental Noise Guidelines for the European Region will provide evidence-based policy guidance to Member States on protecting human health from noise originating from transportation (road traffic, railway and aircraft), wind turbine noise, and leisure noise in settings where people spend the majority of their time...
April 20, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29677052/insights-and-implications-of-new-blood-pressure-guidelines-in-children-and-adolescents
#10
Empar Lurbe, Mieczyslaw Litwin, Denes Pall, Tomas Seeman, Stella Stabouli, Nicholas J A Webb, Elke Wühl
No abstract text is available yet for this article.
April 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29676947/intravenous-chemotherapy-compounding-errors-in-a-follow-up-pan-canadian-observational-study
#11
Rachel E Gilbert, Melissa C Kozak, Roxanne B Dobish, Venetia C Bourrier, Paul M Koke, Vishal Kukreti, Heather A Logan, Anthony C Easty, Patricia L Trbovich
PURPOSE: Intravenous (IV) compounding safety has garnered recent attention as a result of high-profile incidents, awareness efforts from the safety community, and increasingly stringent practice standards. New research with more-sensitive error detection techniques continues to reinforce that error rates with manual IV compounding are unacceptably high. In 2014, our team published an observational study that described three types of previously unrecognized and potentially catastrophic latent chemotherapy preparation errors in Canadian oncology pharmacies that would otherwise be undetectable...
April 20, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29676935/current-and-emerging-two-drug-approaches-for-hiv-1-therapy-in-art-na%C3%A3-ve-and-art-experienced-virologically-suppressed-patients
#12
Barbara Rossetti, Francesca Montagnani, Andrea De Luca
Current guidelines recommend a 2-drug antiretroviral regimen as an alternative to triple antiretroviral therapy (ART) in selected patients to reduce long-term toxicity and costs. Areas covered: This review is intended to provide insight into the efficacy, safety and tolerability of 2-drug versus 3-drug ART in naïve and in treatment-experienced virologically-suppressed patients. Expert opinion: Dual therapy regimens are not feasible in HBV-coinfected individuals and should not be applied during pregnancy. Positive data on 2-drug ART in drug naïve patients are still limited, while, in virologically-suppressed individuals, several regimens have shown non-inferiority as compared to 3-drug regimens...
April 20, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29676896/alkyne-origami-folding-oligoalkynes-into-polyaromatics
#13
Igor V Alabugin, Edgar Gonzalez-Rodriguez
Do not bend the triple bonds! This familiar undergraduate mantra must be disobeyed if the alkyne group is used as a building block in molecular construction. This Account will describe our exploits in "alkyne origami", that is, folding oligoalkynes into new shapes via cyclization cascades. This research stems from a set of guidelines for the cyclizations of alkynes that we suggested in 2011 ( Gilmore Chem. Rev. 2011 , 111 , 6513 ; Alabugin J. Am. Chem. Soc. 2011 , 133 , 12608 ). The guidelines blended critical analysis of ∼40 years of experimental research with computations into the comprehensive predictions of the relative favorability of dig-cyclizations of anions and radicals...
April 20, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29675701/incidental-findings-on-hybrid-spect-ct-and-pet-ct-scanners-is-it-time-for-new-training-and-reporting-guidelines
#14
EDITORIAL
Steven Port
No abstract text is available yet for this article.
April 12, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29675660/rates-of-prevalent-colorectal-cancer-occurrence-in-persons-75-years-of-age-and-older-a-population-based-national-study
#15
Vijit Chouhan, Emad Mansoor, Sravanthi Parasa, Gregory S Cooper
BACKGROUND/AIMS: There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, population-based database as this may impact screening guidelines in this population. METHODS: Utilizing a commercial database (Explorys Inc, Cleveland, OH), we identified a cohort of patients with a first-ever diagnosis of CRC between 2012 and 2017 based on the Systematized Nomenclature of Medicine-Clinical Terms...
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29675642/dutch-guideline-for-clinical-foetal-neonatal-and-paediatric-post-mortem-radiology-including-a-review-of-literature
#16
REVIEW
L J P Sonnemans, M E M Vester, E E M Kolsteren, J J H M Erwich, P G J Nikkels, P A M Kint, R R van Rijn, W M Klein
Clinical post-mortem radiology is a relatively new field of expertise and not common practice in most hospitals yet. With the declining numbers of autopsies and increasing demand for quality control of clinical care, post-mortem radiology can offer a solution, or at least be complementary. A working group consisting of radiologists, pathologists and other clinical medical specialists reviewed and evaluated the literature on the diagnostic value of post-mortem conventional radiography (CR), ultrasonography, computed tomography (PMCT), magnetic resonance imaging (PMMRI), and minimally invasive autopsy (MIA)...
April 19, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29674626/prognostic-significances-of-overexpression-myc-and-or-bcl2-in-r-chop-treated-diffuse-large-b-cell-lymphoma-a-systematic-review-and-meta-analysis
#17
Lu Li, Yanyan Li, Ximei Que, Xue Gao, Qian Gao, Mingxing Yu, Kaili Ma, Yanfeng Xi, Tong Wang
Numerous studies have investigated the prognostic values of MYC and/or BCL2 protein overexpression in diffuse large B-cell lymphoma (DLBCL). However, the results still demonstrate discrepancies among different studies. We aimed to do a systematic review and meta-analysis on the relationships between overexpression MYC and/or BCL2 and DLBCLs treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). This study followed the guidelines of PRISMA and Cochrane handbook. The hazard ratios (HRs) for overall survival (OS) were pooled to estimate the main effect size...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674444/adjuvant-chemotherapy-seemed-not-to-have-survival-benefit-in-rectal-cancer-patients-with-yptis-2n0-after-preoperative-radiotherapy-and-surgery-from-a-population-based-propensity-score-analysis
#18
Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng, San-Jun Cai
BACKGROUND: Adjuvant chemotherapy is currently offered routinely, as standard, after radical resection for patients with rectal cancer receiving neo-adjuvant chemoradiation. However, the efficacy of adjuvant chemotherapy in patients with ypTis-2N0M0 has not been documented to the same extent, and the survival benefit remained controversial. The purpose of this work was to determine the role of chemotherapy in patients with ypTis-2N0M0 classification. MATERIALS AND METHODS: Data were obtained from the Surveillance, Epidemiology, and End Results database ( n  = 4,217)...
April 19, 2018: Oncologist
https://www.readbyqxmd.com/read/29674046/development-of-a-chromatographic-method-with-multi-criteria-decision-making-design-for-simultaneous-determination-of-nifedipine-and-atenolol-in-content-uniformity-testing
#19
Sameh Ahmed, Abdulmalik Alqurshi, Abdel-Maaboud Ismail Mohamed
A new robust and reliable high-performance liquid chromatography (HPLC) method with multi-criteria decision making (MCDM) approach was developed to allow simultaneous quantification of atenolol (ATN) and nifedipine (NFD) in content uniformity testing. Felodipine (FLD) was used as an internal standard (I.S.) in this study. A novel marriage between a new interactive response optimizer and a HPLC method was suggested for multiple response optimizations of target responses. An interactive response optimizer was used as a decision and prediction tool for the optimal settings of target responses, according to specified criteria, based on Derringer's desirability...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673823/carotid-artery-endarterectomy-cea-vs-carotid-artery-stenting-cas-for-restenosis-after-cea-a-systematic-review-and-meta-analysis
#20
REVIEW
Pavlos Texakalidis, Stefanos Giannopoulos, Anil K Jonnalagadda, Damianos G Kokkinidis, Theofilos Machinis, John Reavey-Cantwell, Ehrin J Armstrong, Pascal Jabbour
BACKGROUND: Carotid artery restenosis may occur following ipsilateral carotid endarterectomy (CEA). It remains unclear whether carotid artery stenting (CAS) or a repeat CEA (redoCEA) is the best treatment strategy for carotid artery restenosis. OBJECTIVE: We sought to find whether CAS or redoCEA is the optimal therapy for post-endarterectomy carotid restenosis. METHODS: This study was performed according to the PRISMA and MOOSE guidelines...
April 16, 2018: World Neurosurgery
keyword
keyword
48381
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"