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https://www.readbyqxmd.com/read/29245184/evaluation-of-the-use-of-novel-biomarkers-to-augment-antimicrobial-stewardship-program-activities
#1
Kayla R Stover, Rachel M Kenney, Travis S King, Alan E Gross
As antimicrobial stewardship increasingly receives worldwide attention for improving patient care by optimizing antimicrobial therapy, programs are evaluating new tools that may augment antimicrobial stewardship activities. Biomarkers are objective, accurate, and reproducible measures that provide information about medical conditions. A systematic literature search using PubMed/MEDLINE databases was performed to evaluate the use of novel biomarkers as additions to the antimicrobial stewardship armamentarium...
December 15, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29244491/surface-cluster-catalyst-for-n2-to-nh3-thermal-conversion
#2
Xue-Lu Ma, Jin-Cheng Liu, Hai Xiao, Jun Li
The ammonia synthesis from N2 is of vital importance, with imitating biological nitrogen fixation attracted much interest. Herein, we investigate the catalytic mechanisms of N2-to-NH3 thermal conversion on the singly dispersed bimetallic catalyst Rh1Co3/CoO(011), and find that the preferred pathway is an associative mechanism analogous to the biological process, in which alternating hydrogenations of the N2 occur, with H2 activation on both metal sites. We propose that the singly dispersed bimetallic M1An catalyst, in which the doped metal atom M substitutes an oxygen atom on the oxide surface of metal A, serves as a new surface single-cluster catalyst (SCC) design platform for the biomimetic N2-to-NH3 thermal conversion...
December 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29244250/human-innate-lymphoid-cells-ilcs-towards-a-uniform-immune-phenotyping
#3
REVIEW
Sara Trabanelli, Alejandra Gomez Cadena, Domenico Mavilio, Basile Nicolas Landis, Peter Jandus, Camilla Jandus
Helper Innate Lymphoid Cells (ILCs), the most recently identified population of the Innate Lymphoid Cell family, plays a fundamental role in the restoration of tissue integrity, in the protection against infiltrating pathogens as well as in tumor immune-surveillance. ILCs have been divided into three main subsets, ILC1, ILC2 and ILC3, that can be specifically activated by different signals coming either from pathogens or from other cell populations, including cancer cells. Following activation, ILCs are in turn able to promptly secrete a wide range of soluble mediators that modulate effector cell functions...
December 15, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29243903/update-on-current-care-guideline-psoriasis-skin-and-joints
#4
(no author information available yet)
Psoriasis is a chronic, immune-mediated, inflammatory disorder of the skin and joints. Moderate-to-server cases are associated with an independent risk of comorbidity (cardiovascular diseases and diabetes) even after adjusting for risk factors, known to be more prevalent in psoriatics compared to normal population. The systemic underlying inflammation, analogous to that observed in rheumatoid arthritis, calls for a long-term effective treatment. Screening and treatment of cardiovascular risk factors is highly recommended...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29243483/relative-binding-free-energy-calculations-in-drug-discovery-recent-advances-and-practical-considerations
#5
Zoe Cournia, Bryce Allen, Woody Sherman
Accurate in silico prediction of protein-ligand binding affinities has been a primary objective of structure-based drug design for decades due to the putative value it would bring to the drug discovery process. However, computational methods have historically failed to deliver value in real-world drug discovery applications due to a variety of scientific, technical, and practical challenges. Recently, a family of approaches commonly referred to as relative binding free energy (RBFE) calculations, which rely on physics-based molecular simulations and statistical mechanics, have shown promise in reliably generating accurate predictions in the context of drug discovery projects...
December 15, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29243038/what-performance-analysts-need-to-know-about-research-trends-in-association-football-2012-2016-a-systematic-review
#6
REVIEW
Hugo Sarmento, Filipe Manuel Clemente, Duarte Araújo, Keith Davids, Allistair McRobert, António Figueiredo
BACKGROUND: Evolving patterns of match analysis research need to be systematically reviewed regularly since this area of work is burgeoning rapidly and studies can offer new insights to performance analysts if theoretically and coherently organized. OBJECTIVE: The purpose of this paper was to conduct a systematic review of published articles on match analysis in adult male football, identify and organize common research topics, and synthesize the emerging patterns of work between 2012 and 2016, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines...
December 14, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29241885/cost-effectiveness-of-the-angiotensin-receptor-neprilysin-inhibitor-sacubitril-valsartan-for-patients-with-chronic-heart-failure-and-reduced-ejection-fraction-in-the-netherlands-a-country-adaptation-analysis-under-the-former-and-current-dutch-pharmacoeconomic
#7
Isaac Corro Ramos, Matthijs M Versteegh, Rudolf A de Boer, Jolanda M A Koenders, Gerard C M Linssen, Joan G Meeder, Maureen P M H Rutten-van Mölken
OBJECTIVES: To describe the adaptation of a global health economic model to determine whether treatment with the angiotensin receptor neprilysin inhibitor LCZ696 is cost effective compared with the angiotensin-converting enzyme inhibitor enalapril in adult patients with chronic heart failure with reduced left ventricular ejection fraction in the Netherlands; and to explore the effect of performing the cost-effectiveness analyses according to the new pharmacoeconomic Dutch guidelines (updated during the submission process of LCZ696), which require a value-of-information analysis and the inclusion of indirect medical costs of life-years gained...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241881/ispor-code-of-ethics-2017-4th-edition
#8
Jessica Santos, Francis Palumbo, Elizabeth Molsen-David, Richard J Willke, Louise Binder, Michael Drummond, Anita Ho, William D Marder, Louise Parmenter, Gurmit Sandhu, Asrul A Shafie, David Thompson
As the leading health economics and outcomes research (HEOR) professional society, ISPOR has a responsibility to establish a uniform, harmonized international code for ethical conduct. ISPOR has updated its 2008 Code of Ethics to reflect the current research environment. This code addresses what is acceptable and unacceptable in research, from inception to the dissemination of its results. There are nine chapters: 1 - Introduction; 2 - Ethical Principles respect, beneficence and justice with reference to a non-exhaustive compilation of international, regional, and country-specific guidelines and standards; 3 - Scope HEOR definitions and how HEOR and the Code relate to other research fields; 4 - Research Design Considerations primary and secondary data related issues, e...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241618/appropriateness-of-clinical-severity-classification-of-new-who-childhood-pneumonia-guidance-a-multi-hospital-retrospective-cohort-study
#9
Ambrose Agweyu, Richard J Lilford, Mike English
BACKGROUND: Management of pneumonia in many low-income and middle-income countries is based on WHO guidelines that classify children according to clinical signs that define thresholds of risk. We aimed to establish whether some children categorised as eligible for outpatient treatment might have a risk of death warranting their treatment in hospital. METHODS: We did a retrospective cohort study of children aged 2-59 months admitted to one of 14 hospitals in Kenya with pneumonia between March 1, 2014, and Feb 29, 2016, before revised WHO pneumonia guidelines were adopted in the country...
January 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29240816/the-sociotype-construct-gauging-the-structure-and-dynamics-of-human-sociality
#10
Pedro C Marijuán, Jesús Montero-Marín, Jorge Navarro, Javier García-Campayo, Raquel Del Moral
Exploring the pertinence of a "sociotype" construct, established along the conceptual chain genotype-phenotype-sociotype, is the essential purpose of the present paper. Further, by following the sociotype's conceptual guidelines, a new psychometric indicator has been developed in order to gauge the level of social interaction around each individual-the sociotype questionnaire (SOCQ). A first version of this questionnaire has been elaborated by gathering data about the different classes of social bonds (family, friends, acquaintances, and work/study colleagues) in general population and about the dynamic update of these bonds via face-to-face conversation and other modes of interaction...
2017: PloS One
https://www.readbyqxmd.com/read/29240765/drug-resistance-and-treatment-failure-in-leishmaniasis-a-21st-century-challenge
#11
REVIEW
Alicia Ponte-Sucre, Francisco Gamarro, Jean-Claude Dujardin, Michael P Barrett, Rogelio López-Vélez, Raquel García-Hernández, Andrew W Pountain, Roy Mwenechanya, Barbara Papadopoulou
Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently needed on a global basis because treatment failure is an increasing problem. Drug resistance is a fundamental determinant of treatment failure, although other factors also contribute to this phenomenon, including the global HIV/AIDS epidemic with its accompanying impact on the immune system. Pentavalent antimonials have been used successfully worldwide for the treatment of leishmaniasis since the first half of the 20th century, but the last 10 to 20 years have witnessed an increase in clinical resistance, e...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29240760/novel-linear-motif-filtering-protocol-reveals-the-role-of-the-lc8-dynein-light-chain-in-the-hippo-pathway
#12
Gábor Erdős, Tamás Szaniszló, Mátyás Pajkos, Borbála Hajdu-Soltész, Bence Kiss, Gábor Pál, László Nyitray, Zsuzsanna Dosztányi
Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases. These types of interactions are usually characterized by a specific binding motif that captures the key amino acids shared among the interaction partners. However, the computational proteome-level identification of interaction partners based on the known motif is hindered by the huge number of randomly occurring matches from which biologically relevant motif hits need to be extracted...
December 14, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29240744/an-osteoarthritis-model-of-care-should-be-a-national-priority-for-new-zealand
#13
Jennifer Baldwin, Andrew Briggs, Warwick Bagg, Peter Larmer
Osteoarthritis is highly prevalent, disabling and costly to the person and the community. The burden of this chronic condition is predicted to increase dramatically over the coming decades. Healthcare spending on osteoarthritis is unsustainable and action is needed to improve care delivery. At present, there is an over-emphasis on surgical and pharmacological interventions, despite evidence supporting conservative treatments such as exercise, weight loss and education. While clinical guidelines provide recommendations regarding best practice (ie, what to do), they fail to address how to operationalise these recommendations into clinical practice...
December 15, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29240594/preventive-effect-of-a-microclimate-regulating-system-on-pressure-ulcer-development-a-prospective-randomized-controlled-trial-in-dutch-nursing-homes
#14
Martin van Leen, Ruud Halfens, Jos Schols
OBJECTIVE: Prevention of pressure ulcers (PrUs) is based on relieving pressure, diminishing shear stress, and controlling the skin's microclimate. Based on the recommendations in the most recent guideline for prevention of PrUs, a pressure-relieving, shear stress-diminishing, and microclimate-controlling skin interface multilayer support system (Bedcare; Sense Textile, 's-Hertogenbosch, the Netherlands) has been developed for use on top of a viscoelastic foam mattress (Formafoam, Kabelfabriek Eupen, Belgium)...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29240456/trainees-perceptions-of-feedback-validity-evidence-for-two-feedme-feedback-in-medical-education-instruments
#15
Robert Bing-You, Saradha Ramesh, Victoria Hayes, Kalli Varaklis, Denham Ward, Maria Blanco
Construct: Medical educators consider feedback a core component of the educational process. Effective feedback allows learners to acquire new skills, knowledge, and attitudes. Learners' perceptions of feedback are an important aspect to assess with valid methods in order to improve the feedback skills of educators and the feedback culture. BACKGROUND: Although guidelines for delivering effective feedback have existed for several decades, medical students and residents often indicate that they receive little feedback...
December 14, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/29238196/the-role-of-new-antidepressants-in-clinical-practice-in-canada-a-brief-review-of-vortioxetine-levomilnacipran-er-and-vilazodone
#16
REVIEW
Roger S McIntyre
Although many branded and generic antidepressants are approved for the treatment of major depressive disorder (MDD) in Canada, efficacy and tolerability differ among patients, and new treatment options are needed. Symptom types (eg, fatigue, energy/motivation, cognition, and functioning), medication type, treatment duration, and the need for maintenance therapy are factors that may influence treatment effectiveness. Three antidepressants, vortioxetine, levomilnacipran extended-release (ER), and vilazodone have recently become available in Canada...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29237305/e-a%C3%A2-ratio-a-simple-detector-of-left-ventricular-dysfunction-in-patients-with-decreased-ejection-fraction
#17
Benny Johansson, Fredrik Lundin, Rolf Tegerback, Leif Bojö
OBJECTIVES: Could a diastolic dysfunction and an increased LV-filling pressure according to ASE/EACVI guidelines be detected or ruled out by the E/a´ratio in patients with decreased ejection fraction. DESIGN: We retrospectively evaluated the diastolic function of 113 unselected in-hospital patients, aged 40-84 years, in sinus rhythm and with no or mild valve disease, having a decreased systolic function (EF ≤50%) using the new ASE/EACVI guidelines and compared these results with the E/a´ratio derived from the E wave in the mitral flow and the a´velocity in the tissue Doppler...
December 14, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29236978/impact-of-the-2016-ase-eacvi-recommendations-on-the-prevalence-of-diastolic-dysfunction-in-the-general-population
#18
João G Almeida, Ricardo Fontes-Carvalho, Francisco Sampaio, José Ribeiro, Paulo Bettencourt, Frank A Flachskampf, Adelino Leite-Moreira, Ana Azevedo
Aims: Diastolic dysfunction (DD) is frequent in the general population; however, the assessment of diastolic function remains challenging. We aimed to evaluate the impact of the recent 2016 American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) recommendations in the prevalence and grades of DD compared with the 2009 guidelines and the Canberra Study Criteria (CSC). Methods and results: Within a population-based cohort, a total of 1000 individuals, aged ≥45 years, were evaluated retrospectively...
December 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29236757/high-genetic-structure-and-low-mitochondrial-diversity-in-bottlenose-dolphins-of-the-archipelago-of-bocas-del-toro-panama-a-population-at-risk
#19
Dalia C Barragán-Barrera, Laura J May-Collado, Gabriela Tezanos-Pinto, Valentina Islas-Villanueva, Camilo A Correa-Cárdenas, Susana Caballero
The current conservation status of the bottlenose dolphin (Tursiops truncatus) under the IUCN is 'least concern'. However, in the Caribbean, small and localized populations of the 'inshore form' may be at higher risk of extinction than the 'worldwide distributed form' due to a combination of factors including small population size, high site fidelity, genetic isolation, and range overlap with human activities. Here, we study the population genetic structure of bottlenose dolphins from the Archipelago of Bocas del Toro in Panama...
2017: PloS One
https://www.readbyqxmd.com/read/29236272/medical-malpractice-and-transoral-robotic-surgery-evaluation-and-some-preemptive-thoughts
#20
Daniel D Lydiatt, Ryan Sewell
Medical malpractice is costly and disruptive, and it is important to prevent. We conducted a study with the objective to look at medical malpractice in robotic surgery overall, to evaluate reasons for litigation, and to comment on possible strategies to avoid litigation with transoral robotic surgery. We used the Westlaw computerized database to identify all state and federal verdict summaries in medical malpractice cases. We found 17 cases alleging malpractice that involved the use of robotic surgery. In all, the plaintiffs in 6 cases (35%) contended that an open rather than a robotic approach should have been used, 5 (29%) alleged negligent credentialing, 4 (24%) alleged training deficiencies, 2 (12%) alleged manufacturing problems, and 1 (6%) charged that robotic surgery should have been performed instead of open surgery (1 case involved two of these allegations)...
December 2017: Ear, Nose, & Throat Journal
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