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https://www.readbyqxmd.com/read/29058148/complete-genome-sequence-of-two-tomato-infecting-begomoviruses-in-venezuela-evidence-of-a-putative-novel-species-and-a-novel-recombinant-strain
#1
Gustavo Romay, Dorys T Chirinos, Francis Geraud-Pouey, Annika Gillis, Jacques Mahillon, Claude Bragard
At least six begomovirus species have been reported infecting tomato in Venezuela. In this study the complete genomes of two tomato-infecting begomovirus isolates (referred to as Trujillo-427 and Zulia-1084) were cloned and sequenced. Both isolates showed the typical genome organization of New World bipartite begomoviruses, with DNA-A genomic components displaying 88.8% and 90.3% similarity with established begomoviruses, for isolates Trujillo-427 and Zulia-1084, respectively. In accordance to the guidelines for begomovirus species demarcation, the Trujillo-427 isolate represents a putative new species and the name "Tomato wrinkled mosaic virus" is proposed...
October 20, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29057801/revealing-the-effects-of-nanoscale-membrane-curvature-on-lipid-mobility
#2
Abir Maarouf Kabbani, Xinxin Woodward, Christopher V Kelly
Recent advances in nanoengineering and super-resolution microscopy have enabled new capabilities for creating and observing membrane curvature. However, the effects of curvature on single-lipid diffusion have yet to be revealed. The simulations presented here describe the capabilities of varying experimental methods for revealing the effects of nanoscale curvature on single-molecule mobility. Traditionally, lipid mobility is revealed through fluorescence recovery after photobleaching (FRAP), fluorescence correlation spectroscopy (FCS), and single particle tracking (SPT)...
October 18, 2017: Membranes
https://www.readbyqxmd.com/read/29057642/insulin-therapy-for-adult-patients-with-type-2-diabetes-mellitus-a-position-statement-of-the-korean-diabetes-association-2017
#3
Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi
The Korean Diabetes Association (KDA) has regularly updated its Clinical Practice Guidelines. In 2017, the KDA published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). Growing evidence from new multinational clinical trials using novel and traditional insulin analogues has also been accumulated. Following global trends, many results of clinical trials, especially concerning the clinical efficacy and safety of insulin therapy, have been published about Korean patients with T2DM...
October 23, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29057598/separation-of-structurally-related-primary-aliphatic-amines-using-hydrophilic-interaction-chromatography-with-fluorescence-detection-after-postcolumn-derivatization-with-o-phtaldialdehyde-mercaptoethanol
#4
Michal Douša, Jan Doubský
The retention behavior of primary aliphatic amines (homologous series of aliphatic alkyl amines and cycloalkyl amines) and positional isomers of alkylamines in the hydrophilic interaction chromatography mode was studied. The study was carried out on a TSKgel Amide-80 column followed by post-column derivatization with fluorescence detection to describe the retention mechanism of tested compounds. The effect of chromatographic conditions including column temperature, acetonitrile content in the mobile phase, mobile phase pH (ranging from 3...
October 23, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29057461/clinical-guidelines-for-working-with-stepfamilies-what-family-couple-individual-and-child-therapists-need-to-know
#5
Patricia Papernow
This article draws on four decades of research and clinical practice to delineate guidelines for evidence-informed, clinically sound work with stepfamilies for couple, family, individual adult, and child therapists. Few clinicians receive adequate training in working with the intense and often complex dynamics created by stepfamily structure and history. This is despite the fact that stepfamilies are a fundamentally different family form that occurs world-wide. As a result many clinicians rely on their training in first-time family models...
October 22, 2017: Family Process
https://www.readbyqxmd.com/read/29057006/risk-factors-for-self-report-of-not-receiving-an-hiv-test-among-adolescents-in-nyc-with-a-history-of-sexual-intercourse-2013-yrbs
#6
Tina Y Gao, Chanelle J Howe, Andrew R Zullo, Brandon D L Marshall
The Centers for Disease Control and Prevention (CDC) has previously recommended that all adolescents undergo HIV testing in the United States (US). Despite these recommendations, national HIV testing among US adolescents has remained low. This study estimated the prevalence of and identified risk factors for not receiving an HIV test among adolescents with a history of sexual intercourse in New York City (NYC), an urban area that has been greatly impacted by the HIV epidemic. Cross-sectional data on 1,199 NYC high school students who completed the 2013 NYC Youth Risk Behavior Survey were used...
2017: Vulnerable Children and Youth Studies
https://www.readbyqxmd.com/read/29056979/a-critique-of-the-new-canadian-fetal-alcohol-spectrum-disorder-guideline
#7
John D McLennan, Peter Braunberger
A new Fetal Alcohol Spectrum Disorder (FASD) guideline was published in the Canadian Medical Association Journal in 2016. This is relevant to the mental health field as mental health symptoms and psychiatric disorders are often identified as associated with and/or part of FASD presentations. Unfortunately, the new guideline has not advanced understanding of the interface between FASD and mental health problems; rather it may contribute to additional confusion. For example, a new recommendation to include additional mental health symptoms, such as anxiety and affect dysregulation, as manifestations contributing to a diagnosis of FASD is particularly concerning given the paucity of evidence supporting this assertion and the potential to distort delivery of mental health interventions for mental health problems...
2017: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29056246/diagnostic-yield-from-339-epilepsy-patients-screened-on-a-clinical-gene-panel
#8
Kameryn M Butler, Cristina da Silva, John J Alexander, Madhuri Hegde, Andrew Escayg
BACKGROUND: The contribution of genetic factors to epilepsy has long been recognized and has been estimated to play a role in 70% to 80% of cases. Identification of a pathogenic variant can help families to better cope with the disorder, allows for genetic counseling to determine recurrence risk, and in some cases, can directly influence treatment options. In this study, we determined the diagnostic yield of a clinical gene panel applied to an unselected cohort of epilepsy patients. METHODS: Variant reports from 339 clinically referred epilepsy patients screened using a 110-gene panel were retrospectively reviewed...
September 6, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29056238/value-of-routine-investigations-to-predict-loop-diuretic-down-titration-success-in-stable-heart-failure
#9
Pieter Martens, Frederik H Verbrugge, Levinia Boonen, Petra Nijst, Matthias Dupont, Wilfried Mullens
AIMS: Guidelines advocate down-titration of loop diuretics in chronic heart failure (CHF) when patients have no signs of volume overload. Limited data are available on the expected success rate of this practice or how routine diagnostic tests might help steering this process. METHODS AND RESULTS: Fifty ambulatory CHF-patients on stable neurohumoral blocker/diuretic therapy for at least 3months without any clinical sign of volume overload were prospectively included to undergo loop diuretic down-titration...
October 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29056038/antihyperglycemic-agent-therapy-for-adult-patients-with-type-2-diabetes-mellitus-2017-a-position-statement-of-the-korean-diabetes-association
#10
Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
In 2017, the Korean Diabetes Association (KDA) published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). The KDA regularly updates its Clinical Practice Guidelines, but since the last update in 2015, many results from clinical trials have been introduced, and domestic data from studies performed in Korean patients with T2DM have been published. Recently, evidence from large clinical studies assessing cardiovascular outcomes following the use of sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists in patients with T2DM were incorporated into the recommendations...
October 23, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29056003/-new-advances-in-the-diagnosis-of-liver-fibrosis
#11
S Y Chen, Y M Sun, H You
Various chronic liver diseases may progress to liver fibrosis or liver cirrhosis. Assessment of the degree of liver fibrosis helps with clinical decision-making, prognosis prediction, and evaluation of therapeutic effect, and therefore, accurate diagnosis and evaluation of the degree of liver fibrosis is a research hotspot at present. The advances in the diagnosis of liver fibrosis in recent years include the publication of international consensuses and guidelines, evaluation of the outcome of liver fibrosis after antiviral therapy, development of the diagnosis of liver fibrosis in patients with non-viral hepatitis, and constant update of noninvasive diagnostic techniques...
August 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29055746/atrial-fibrillation-and-arterial-hypertension
#12
REVIEW
M S Kallistratos, L E Poulimenos, A J Manolis
Atrial fibrillation (AF) and arterial hypertension frequently coexist, not only because arterial hypertension increases the incidence of new onset of atrial fibrillation, but also because those two entities share common risk factors and conditions that increase the incidence of both. Thus, in our daily clinical practice we will often have to manage and treat those patients. In order to assess and treat these patients, proper blood pressure (BP) measurement as well as detection of atrial fibrillation is mandatory...
October 18, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29055511/the-relationship-between-causative-microorganisms-and-cardiac-lesions-caused-by-infective-endocarditis-new-perspectives-from-the-contemporary-cohort-of-patients
#13
Danijela Trifunovic, Bosiljka Vujisic-Tesic, Biljana Obrenovic-Kircanski, Branislava Ivanovic, Dimitra Kalimanovska-Ostric, Milan Petrovic, Marija Boricic-Kostic, Snezana Matic, Goran Stevanovic, Jelena Marinkovic, Olga Petrovic, Gordana Draganic, Mirjana Tomic-Dragovic, Svetozar Putnik, Dejan Markovic, Vladimir Tutus, Ivana Jovanovic, Maja Markovic, Ivana M Petrovic, Jelena M Petrovic, Jelena Stepanovic
BACKGROUND: The etiology of infective endocarditis (IE) is changing. More aggressive forms with multiple IE cardiac lesions have become more frequent. This study sought to explore the relationship between contemporary causative microorganisms and IE cardiac lesions and to analyze the impact of multiple lesions on treatment choice. METHODS: In 246 patients hospitalized for IE between 2008 and 2015, cardiac lesions caused by IE were analyzed by echocardiography, classified according to the 2015 European Society of Cardiology guidelines and correlated with microbiological data...
October 18, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29055445/systematic-review-of-depression-in-patients-with-multiple-sclerosis-and-its-relationship-to-interferon%C3%AE-treatment
#14
REVIEW
Leila Alba Palé, Jordi León Caballero, Berta Samsó Buxareu, Purificación Salgado Serrano, Víctor Pérez Solà
BACKGROUND: Multiple sclerosis is a chronic disease considered the major cause of neurological disability in young adults worldwide. While depression is considered a determinant factor of impaired quality of life and poorer prognosis among patients with multiple sclerosis, it is very often dismissed and undertreated by physicians. Depression has been related to treatment with some immunomodulatory drugs, such as IFNβ. Data from patients who committed suicide during the pivotal study of interferon used as a disease modifying treatment in multiple sclerosis support this association...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29054887/introducing-the-new-bts-guideline-management-of-non-tuberculous-mycobacterial-pulmonary-disease-ntm-pd
#15
EDITORIAL
Charles S Haworth, R Andres Floto
The new BTS Guidelines for the management of non-tuberculous mycobacterial pulmonary disease combine the best available evidence with expert consensus to generate a set of pragmatic Guidelines, published as a supplement to this issue of Thorax, to assist in the management of these challenging infections.
November 2017: Thorax
https://www.readbyqxmd.com/read/29054840/contemporary-risk-stratification-after-myocardial-infarction-in-the-community-performance-of-scores-and-incremental-value-of-soluble-suppression-of-tumorigenicity-2
#16
Yariv Gerber, Susan A Weston, Maurice Enriquez-Sarano, Allan S Jaffe, Sheila M Manemann, Ruoxiang Jiang, Véronique L Roger
BACKGROUND: Current American Heart Association/American College of Cardiology guidelines recommend the GRACE (Global Registry of Acute Coronary Events) and TIMI (Thrombolysis in Myocardial Infarction) scores to assess myocardial infarction (MI) prognosis. Changes in the epidemiological characteristics of MI and the availability of new biomarkers warrant an assessment of the performance of these scores in contemporary practice. We assessed the following: (1) the performance of GRACE and TIMI to predict 1-year mortality in a cohort of patients stratified by ST-segment elevation MI (STEMI) and non-STEMI (NSTEMI) and (2) the incremental discriminatory power of soluble suppression of tumorigenicity-2, a myocardial fibrosis biomarker...
October 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29054125/external-validation-of-a-cancer-risk-prediction-model-for-suspected-head-and-neck-cancer-referrals
#17
T Tikka, V Paleri, K MacKenzie
Head and neck cancer (HNC) affects more than 9000 new patients every year in England and Wales with an additional 1200 in Scotland. (1,2) Patients are urgently referred to head and neck clinics for further assessment when a suspicion of cancer is raised in the primary care setting. In England, the referral criteria are based on the NICE recommendations for symptoms associated with HNC. (2) A different combination of symptoms is described in the Scottish cancer referral guidelines. (3) There is currently no unified referral proforma across the different UK cancer networks...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29053734/an-instrument-to-assess-the-statistical-intensity-of-medical-research-papers
#18
Pentti Nieminen, Jorma I Virtanen, Hannu Vähänikkilä
BACKGROUND: There is widespread evidence that statistical methods play an important role in original research articles, especially in medical research. The evaluation of statistical methods and reporting in journals suffers from a lack of standardized methods for assessing the use of statistics. The objective of this study was to develop and evaluate an instrument to assess the statistical intensity in research articles in a standardized way. METHODS: A checklist-type measure scale was developed by selecting and refining items from previous reports about the statistical contents of medical journal articles and from published guidelines for statistical reporting...
2017: PloS One
https://www.readbyqxmd.com/read/29052849/clinical-applications-of-iddsi-framework-for-texture-recommendation-for-dysphagia-patients
#19
Mingsong Su, Gangying Zheng, Yanqiu Chen, Hua Xie, Weijia Han, Qing Yang, Jianqin Sun, Zhihong Lv, Jianshe Chen
Dysphagia is a highly prevalent eating and swallowing disorder among elderly people, impacting negatively on the health and well-being of those afflicted. With increasing populations of elderly people, food industries are under growing pressure to produce appropriately texture-modified food for safe consumption by these vulnerable populations. Recently published IDDSI framework provides a new global guideline on texture modification and standardization for dysphagia patients. This work was designed to test the feasibility of IDDSI framework for clinical applications by assessing the correlation between swallowing capability of dysphagia patients and the IDDSI texture levels...
October 20, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/29052093/emerging-small-molecule-approaches-to-enhance-the-antimyeloma-benefit-of-proteasome-inhibitors
#20
James J Driscoll, Magen Brailey
Multiple myeloma (MM) is a clonal plasma cell malignancy which, despite recent treatment advances, remains incurable in the vast majority of the over 118,000 patients in the USA afflicted with this disease. Treatment of MM has dramatically improved in the past decade with the introduction of new drugs into therapeutic strategies in both the frontline and relapse settings that has led to a significant improvement in the median overall survival (OS). These drugs have been incorporated into clinical guidelines and transformed the treatment approach to MM...
October 19, 2017: Cancer Metastasis Reviews
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