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https://www.readbyqxmd.com/read/28339439/dezocine-antagonizes-morphine-analgesia-upon-simultaneous-administration-in-rodent-models-of-acute-nociception
#1
Na-Na Li, Ya-Qin Huang, Ling-Er Huang, Shao-Hui Guo, Maxwell R Shen, Chen-Ling Guo, Sheng-Mei Zhu, Yong-Xing Yao
BACKGROUND: Dezocine is a powerful analgesic that can be less addictive than morphine, yet how the two drugs interact in vivo is poorly understood. Here we administered dezocine alone or in combination with morphine to different acute nociception paradigms to explore the interactions of the 2 drugs upon co-administration. OBJECTIVE: To evaluate how dezocine interacts with morphine in different acute nociception paradigms. STUDY DESIGN: Laboratory animal study...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28338180/influence-of-dexmedetomidine-to-cognitive-function-during-recovery-period-for-children-with-general-anesthesia
#2
Z-M Jia, H-N Hao, M-L Huang, D-F Ma, X-L Jia, B Ma
OBJECTIVE: We studied the influence of Dexmedetomidine on cognitive function in children during the recovery period of general anesthesia. PATIENTS AND METHODS: Ninety-three children who underwent general anesthesia were selected and randomly divided into (1) the control group, (2) the dexmedetomidine group, and (3) the dezocine group. Fentanyl, propofol, and rocuronium were used in all patients to induce anesthesia, while sevoflurane inhalation and propofol were used to maintain anesthesia...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28230181/dezocine-exhibits-antihypersensitivity-activities-in-neuropathy-through-spinal-%C3%AE-opioid-receptor-activation-and-norepinephrine-reuptake-inhibition
#3
Yong-Xiang Wang, Xiao-Fang Mao, Teng-Fei Li, Nian Gong, Ma-Zhong Zhang
Dezocine is the number one opioid painkiller prescribed and sold in China, occupying 44% of the nation's opioid analgesics market today and far ahead of the gold-standard morphine. We discovered the mechanisms underlying dezocine antihypersensitivity activity and assessed their implications to antihypersensitivity tolerance. Dezocine, given subcutaneously in spinal nerve-ligated neuropathic rats, time- and dose-dependently produced mechanical antiallodynia and thermal antihyperalgesia, significantly increased ipsilateral spinal norepinephrine and serotonin levels, and induced less antiallodynic tolerance than morphine...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230034/effect-of-dezocine-combined-with-propofol-on-painless-gastroscopy-in-patients-with-suspect-gastric-carcinoma
#4
Ji Ma, Peng Zhang, Yixuan Zhang, Zong Chen, Wenqi Xin, Donghang Zhang, Chuangeng Ma
OBJECTIVE: To evaluate the effect of dezocine combined with propofol on painless gastroscopy in patients with suspect gastric carcinoma. METHODS: Forty-three patients with gastric carcinoma who have underwent painless gastroscopy were retrospectively analyzed. For the 43 patients, 21 patients received propofol 1 mg/kg for painless gastroscopy (control group) and other 22 cases received dezocine 20 µg/kg plus propofol 1 mg/kg for painless gastroscopy (experiment group)...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28017828/effect-of-dezocine-on-il-12-and-il-10-secretion-and-lymphocyte-activation-by-culturing-dendritic-cells-from-human-umbilical-cord-blood
#5
Chang Feng, Man Feng, Ran Jiao, Dongyi Liu, Yanwu Jin, Xin Zhao, Ruixue Xiao
Dezocine has been generally utilized for pain therapy and auxiliary anesthesia. Although it has some advantages on the prevention of some anesthesia related complications, its effect on immune responses remains unclear. Our study investigated the effects of Dezocine on IL-10 and IL-12 secretion and lymphocytes activation by culturing dendritic cells (DCs), and revealed the underlying mechanism. Mononuclear cells were divided into negative control group (GN), positive control group (GP), experimental group (GD; GD5, D7, D9)...
December 22, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27766513/risk-factors-for-postoperative-delirium-after-spine-surgery-in-middle-and-old-aged-patients
#6
Xin Jiang, Dong Chen, Yahao Lou, Zhongshi Li
BACKGROUND: Postoperative delirium is a common complication following various operative procedures with an incidence rate of 10-77 %. AIM: To analyze various risk factors for postoperative delirium after spine surgery in the middle- and old-aged patients. METHODS: This study retrospectively reviewed 451 patients (226 males and 225 females, an average age of 65.1 ± 18.3 years) who underwent spinal surgery in our hospital between January 2010 and August 2015...
October 20, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27721247/oxycodone-versus-dezocine-for-postoperative-analgesia-in-patients-with-cervical-cancer-treated-with-radical-surgery
#7
Zhonghua Li, Honglian Wu, Renhong He, Xiaowei Hu, Shaoxiao Liu
OBJECTIVE: The aim of this study was to evaluate oxycodone versus dezocine for postoperative analgesia in patients with cervical cancer treated with radical surgery. MATERIALS AND METHODS: Fifty-one cases of cervical cancer treated with radical surgery were included in the present study and divided into oxycodone group (n = 26) and dezocine group (n = 25). Patients in the oxycodone group were given with oxycodone 1 mg/kg plus tropisetron 0.1 mg/kg diluting to 100 ml by 0...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27687431/different-interventions-in-preventing-opioid-induced-cough-a-meta-analysis
#8
REVIEW
Li Shuying, Li Ping, Ni Juan, Luo Dong
BACKGROUND: Cough is one of the most common complications of opioids. Many studies have evaluated the effect of various drugs in preventing opioid-induced cough (OIC). However, there is existing controversy about those reports. The present study was performed to assess the efficacy of different interventions on OIC. METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and Embase to identify randomized controlled trials on the efficacy of different drugs in the prevention of OIC...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27686642/-random-clinical-study-about-application-value-of-oxycodone-in-radiofrequency-ablation-of-hepatocellular-carcinoma
#9
Y Q Yao, Y H Liu, Z Y Fan, J H Chen, C J Dong
Objective: To evaluate the clinical effect and safety of oxycodone hydrochloride in the anesthesia for percutaneous radiofrequency ablation (PRFA) in hepatocellular carcinoma. Methods: Between March and December 2015, 60 cases of hepatocellular carcinoma patients undergoing percutaneous radiofrequency ablation surgery in Peking University Cancer Hospital were randomly divided into three groups: oxycodone group (group Q), fentanyl group (group F) and dezocine group (group D), 20 cases in each group. Respectively intravenously injection oxycodone 0...
October 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27350739/clinical-study-of-anesthetization-by-dezocine-combined-with-propofol-for-indolent-colonoscopy
#10
Bin-Bin Xu, Xiao-Liang Zhao, Gui-Ping Xu
AIM: To assess the use of dezocine combined with propofol for the anesthetization of patients undergoing indolent colonoscopy. METHODS: A cross-sectional survey of patients undergoing indolent colonoscopy in the Xinjiang People's Hospital was conducted from April 1 to April 30, 2015. The survey collected patient general information and anesthesia data, including overall medical experience and pain management. Thirty minutes after colonoscopy surgery, samples of venous blood were collected and the biochemical indicators of gastrointestinal function were analyzed...
June 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27159624/analgesic-and-sedative-effects-of-dezocine-and-midazolam-during-vitrectomy
#11
Ying Xiang, Weidi Ye, Na Sun, Xiuming Jin
PURPOSE: To evaluate the analgesic and sedative effectiveness of dezocine and midazolam in vitrectomy. METHODS: One hundred and sixty patients undergoing vitrectomy were randomized into four groups. The control group was given local anesthetic in retrobulbar nerve block only, while the other three groups received a single dose of 0.1 mg/kg dezocine or/and 0.05 mg/kg midazolam (groups D, M, DM), respectively, at 10 min before retrobulbar block. Mean arterial pressure (MAP), heart rate (HR), and oxygen saturation (SpO2) were recorded prior to local anesthesia (Tp), at the start of surgery (T0), 5, 15, 30 min during (T1-T3), and at the end of surgery (T4)...
May 9, 2016: Current Eye Research
https://www.readbyqxmd.com/read/26640403/divergent-effect-of-dezocine-morphine-and-sufentanil-on-intestinal-motor-function-in-rats
#12
Xiaocui Bian, Renlong Zhou, Yuting Yang, Peiying Li, Yannan Hang, Youmin Hu, Liqun Yang, Daxiang Wen
BACKGROUND: Opioid induced bowel dysfunction is the most common side effect of preoperatively administrated morphine, fentanyl and its derivative. However, the influence of dezocine on intestinal mobility is rarely reported. This study was designed to investigate the effects of dezocine, morphine and sufentanil on both intestinal smooth muscle contraction and propulsion in rats. METHODS: Contractile tension and frequency of isolated rat small intestine smooth muscle were measured using tension transducer after incubation with different concentrations of dezocine, morphine and sufentanil...
2015: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/26632125/effects-of-dexmedetomidine-for-retrobulbar-anesthesia-in-orbital-ball-implants-after-enucleation-surgery
#13
RANDOMIZED CONTROLLED TRIAL
Weidi Ye, Zhiyong Hu, Xiuming Jin, Pei Wang
BACKGROUND: Dexmedetomidine (DEX) can prolong the duration of local anesthetics, but the use of retrobulbar DEX has not been fully elucidated. This study was designed to determine the effects of adding DEX to lidocaine-bupivacaine for retrobulbar block in orbital ball implants after enucleation surgery. MATERIALS AND METHODS: A total of 200 patients of both sexes aged 30-60 years of American Society of Anesthesiologists I and II, scheduled for orbital ball implants after enucleation surgery, were enrolled for the study...
September 2015: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/26287536/dezocine-for-preventing-postoperative-pain-a-meta-analysis-of-randomized-controlled-trials
#14
Xuelong Zhou, Chenjing Zhang, Min Wang, LiNa Yu, M Yan
BACKGROUND: Dezocine is considered to be an alternative medication for managing postoperative pain. The aim of this study was to assess the efficacy and safety of this drug in this regard. METHODS: Medline, EMBASE and the Cochrane Central Register of Control Trials (CENTRAL) were searched to identify all randomized controlled trials (RCTs) that compare dezocine with placebo or dezocine with morphine on postoperative pain. The data were extracted and pooled using Mantel-Haenszel random effects model...
2015: PloS One
https://www.readbyqxmd.com/read/26170890/dezocine-prevents-postoperative-hyperalgesia-in-patients-undergoing-open-abdominal-surgery
#15
Fang Yu, Jie Zhou, Suyun Xia, Huan Xu, Xiangrui Wang
Objective. Postoperative hyperalgesia is very frequent and hard to treat. Dezocine is widely used and has a modulatory effect for thermal hyperalgesia in animal models. So, this study was designed to investigate the potential role of dezocine in decreasing postoperative hyperalgesia for patients undergoing open abdominal surgery. Methods. This is a randomized, double-blinded, and placebo-controlled trial. 50 patients for elective open gastrectomy were randomly allocated to either a true treatment group (0.15 mg/kg intravenous dezocine at the end of surgery) or a sham treatment group (equivalent volume of saline) in a 1 : 1 ratio...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26131209/dezocine-attenuates-fentanyl-induced-cough-in-a-dose-dependent-manner-a-randomized-controlled-trial
#16
Yajun Xu, Yun Zhu, Shilai Wang, Yu Ren, Changhong Miao
Fentanyl-induced cough (FIC) should be effectively prevented in patients requiring stable induction of general anesthesia. Our study was to evaluate the suppressive effects of different doses of intravenous dezocine on FIC during the induction of general anesthesia. A total of 400 patients of American Society of Anesthesiologists (ASA) physical status I and II were randomized into four groups (n = 100). Right before Fentanyl bolus, the four groups were given intravenously a matching placebo (group I) (equal volume of 0...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26125754/effects-of-intravenous-analgesia-with-combined-dezocine-and-butorphanol-on-postoperative-cognitive-function-in-elderly-patients
#17
B X Ren, J Zong, J C Tang, D P Sun, X Hui, R Q Li, J L Zhang, Y Ji
The aim of this study was to observe the analgesic effects of the combination of dezocine and butorphanol on postoperative cognitive function in elderly patients. Forty elderly patients undergoing upper abdominal surgeries or thoracotomies with general anesthesia were randomly divided into the dezocine and butorphanol group or the butorphanol group (20 patients per group). A visual analog scale was used to evaluate analgesia and the degree of malignant vomiting. The Ramsay scoring method was used to evaluate sedation...
May 25, 2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25972091/opioids-for-agitation-in-dementia
#18
REVIEW
Richard Brown, Robert Howard, Bridget Candy, Elizabeth L Sampson
BACKGROUND: Agitation is a common experience for people living with dementia, particularly as day-to-day function and cognition start to decline more. At the present time there are limited pharmacological options for relieving agitation and little is known about the safety and efficacy of opioid drugs in this setting. OBJECTIVES: To determine the clinical efficacy and safety of opioids for agitation in people with dementia. SEARCH METHODS: We searched ALOIS, the Cochrane Dementia and Cognitive Improvement Group Specialized Register, on 13 June 2014 using the terms: narcotic OR opioid OR opium OR morphine OR buprenorphine OR codeine OR dextromoramide OR diphenoxylate OR dipipanone OR dextropropoxyphene OR propoxyphene OR diamorphine OR dihydrocodeine OR alfentanil OR fentanyl OR remifentanil OR meptazinol OR methadone OR nalbuphine OR oxycodone OR papaveretum OR pentazocine OR meperidine OR pethidine OR phenazocine OR hydrocodone OR hydromorphone OR levorphanol OR oxymorphone OR butorphanol OR dezocine OR sufentanil OR ketobemidone...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25876640/-application-of-patient-controlled-intravenous-analgesia-of-dezocine-combined-with-sufentanil-in-burn-patients-after-surgery
#19
RANDOMIZED CONTROLLED TRIAL
Shangkun Li, Su Min, Bin Wu, Wanbi Tang
OBJECTIVE: To evaluate the efficacy and safety of patient-controlled intravenous analgesia (PCIA) of dezocine combined with sufentanil in burn patients after escharectomy or tangential excision followed by autologous skin grafting. METHODS: Sixty burn patients hospitalized in Department of Burns and Plastic Surgery of our hospital from February 2011 to December 2013, conforming to the study criteria and going to have escharectomy or tangential excision followed by autologous skin grafting, were divided into sufentanil group (S, n = 30) and dezocine+sufentanil group (DS, n = 30) according to the random number table...
February 2015: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/25784792/dezocine-for-anesthesia-and-stress-reduction-in-induced-abortion
#20
Mengliang Zheng, Yanru Guo, Shiqiang Shan, Sen Yang
BACKGROUND: The purpose of this study was to evaluate the efficacy of dezocine with regard to analgesic and stress reduction outcomes in women undergoing induced abortion. METHODS: A total of 126 women in early pregnancy (up to 14 weeks' gestation) who underwent induced abortion at Cangzhou Central Hospital from May 2012 to May 2013 were randomly assigned to a control (propofol) group (n=63) or an intervention (propofol + dezocine) group (n=63). Wake-up time, orientation force recovery time, incidence of adverse reactions, postoperative visual analog scale (VAS) score, analgesic effect, and respiratory and circulatory monitoring before the operation, 5 minutes into the operation, and 5 minutes after the operation were compared between the two groups...
2015: Patient Preference and Adherence
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