Robert Amson, Andrea Senff-Ribeiro, Teele Karafin, Alexandra Lespagnol, Joane Honoré, Virginie Baylot, Josette Banroques, N Kyle Tanner, Nathalie Chamond, Jordan D Dimitrov, Johan Hoebeke, Nathalie M Droin, Bastien Job, Jonathan Piard, Ulrich-Axel Bommer, Kwang-Wook Choi, Sara Abdelfatah, Thomas Efferth, Stephanie B Telerman, Felipe Correa Geyer, Jorge Reis-Filho, Adam Telerman
Oncogenic intercellular signaling is regulated by extracellular vesicles (EVs), but the underlying mechanisms remain mostly unclear. Since TCTP (translationally controlled tumor protein) is an EV component, we investigated whether it has a role in genotoxic stress signaling and malignant transformation. By generating a Tctp-inducible knockout mouse model (Tctp-/f- ), we report that Tctp is required for genotoxic stress-induced apoptosis signaling via small EVs (sEVs). Human breast cancer cells knocked-down for TCTP show impaired spontaneous EV secretion, thereby reducing sEV-dependent malignant growth...
March 28, 2024: EMBO Reports