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https://www.readbyqxmd.com/read/29679653/effects-of-selective-serotonin-reuptake-inhibitors-ssris-on-human-villous-trophoblasts-syncytialization
#1
Hélène Clabault, Denis Flipo, Jean Guibourdenche, Thierry Fournier, Thomas Sanderson, Cathy Vaillancourt
Selective serotonin-reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants during pregnancy. The human placenta is a highly specialized organ supporting normal growth and development of the fetus. Therefore, this study aims to analyze the effects of SSRIs on villous cytotrophoblasts cells, using BeWo cells and human placental trophoblast cells in primary culture. The SSRIs fluoxetine and its metabolite norfluoxetine, sertraline and venlafaxine did not affect BeWo cell proliferation and viability, nor the percentage of M30-positive (apoptotic) primary trophoblast cells...
April 18, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29677603/the-comparative-evidence-basis-for-the-efficacy-of-second-generation-antidepressants-in-the-treatment-of-depression-in-the-us-a-bayesian-meta-analysis-of-food-and-drug-administration-reviews
#2
Rei Monden, Annelieke M Roest, Don van Ravenzwaaij, Eric-Jan Wagenmakers, Richard Morey, Klaas J Wardenaar, Peter de Jonge
BACKGROUND: Studies have shown similar efficacy of different antidepressants in the treatment of depression. METHOD: Data of phase-2 and -3 clinical-trials for 16 antidepressants (levomilnacipran, desvenlafaxine, duloxetine, venlafaxine, paroxetine, escitalopram, vortioxetine, mirtazapine, venlafaxine XR, sertraline, fluoxetine, citalopram, paroxetine CR, nefazodone, bupropion, vilazodone), approved by the FDA for the treatment of depression between 1987 and 2016, were extracted from the FDA reviews that were used to evaluate efficacy prior to marketing approval, which are less liable to reporting biases...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29676811/determination-of-antidepressants-in-human-urine-extracted-by-magnetic-multiwalled-carbon-nanotube-poly-styrene-co-divinylbenzene-composites-and-separation-by-capillary-electrophoresis
#3
Khaled Murtada, Fernando de Andrés, Angel Ríos, Mohammed Zougagh
Poly(styrene-co-divinylbenzene)-coated magnetic multiwalled carbon nanotube composite synthesized by in-situ high temperature combination and precipitation polymerization of styrene-co-divinylbenzene has been employed as a magnetic sorbent for the solid phase extraction of antidepressants in human urine samples. Fluoxetine, venlafaxine, citalopram and sertraline were, afterwards, separated and determined by capillary electrophoresis with diode array detection. The presence of magnetic multiwalled carbon nanotubes in native poly(styrene-co-divinylbenzene) not only simplified sample treatment but also enhanced the adsorption efficiencies, obtaining extraction recoveries higher than 89...
April 20, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29669175/antidepressants-for-preventing-postnatal-depression
#4
REVIEW
Emma Molyneaux, Laurence A Telesia, Carol Henshaw, Elizabeth Boath, Eleanor Bradley, Louise M Howard
BACKGROUND: Depression is common in the postnatal period and can lead to adverse effects on the infant and wider family, in addition to the morbidity for the mother. It is not clear whether antidepressants are effective for the prevention of postnatal depression and little is known about possible adverse effects for the mother and infant, particularly during breastfeeding. This is an update of a Cochrane Review last published in 2005. OBJECTIVES: To assess the effectiveness of antidepressant medication for the prevention of postnatal depression, in comparison with any other treatment, placebo or standard care...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29666372/brain-serotonin-synthesis-capacity-in-obsessive-compulsive-disorder-effects-of-cognitive-behavioral-therapy-and-sertraline
#5
Jennifer I Lissemore, Debbie Sookman, Paul Gravel, Alexandre Berney, Amir Barsoum, Mirko Diksic, Thomas E Nordahl, Gilbert Pinard, Igor Sibon, Jean Cottraux, Marco Leyton, Chawki Benkelfat
Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are both effective treatments for some patients with obsessive-compulsive disorder (OCD), yet little is known about the neurochemical changes related to these treatment modalities. Here, we used positron emission tomography and the α-[11 C]methyl-L-tryptophan tracer to examine the changes in brain regional serotonin synthesis capacity in OCD patients following treatment with CBT or SSRI treatment. Sixteen medication-free OCD patients were randomly assigned to 12 weeks of either CBT or sertraline treatment...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29665098/patterns-of-antidepressant-use-during-pregnancy-a-nationwide-population-based-cohort-study
#6
Anne Bénard-Laribière, Elodie Pambrun, Anne-Laure Sutter-Dallay, Sophie Gautier, Caroline Hurault-Delarue, Christine Damase-Michel, Isabelle Lacroix, Bernard Bégaud, Antoine Pariente
AIMS: We explored the patterns of antidepressant use during pregnancy. METHODS: A cohort of women who started a pregnancy in 2014 was identified using data from the French reimbursement healthcare system (covering approximately 99% of the population). Antidepressant uses (initiated before or during pregnancy) were assessed. Explored changes in antidepressant treatment were: associations, switches, discontinuation, and resumption of antidepressants during pregnancy...
April 17, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29663484/association-between-psychotropic-medications-and-presence-of-sleep-bruxism-a-systematic-review
#7
REVIEW
Gilberto Melo, Kamile Leonardi Dutra, Rubens Rodrigues Filho, Adriana de Oliveira Lira Ortega, André Luís Porporatti, Bruce Dick, Carlos Flores-Mir, Graziela De Luca Canto
The purpose of this study was to systematically review the literature for studies that investigated the association between use of psychotropic medications and presence of sleep bruxism (SB). Observational studies were selected in a two-phase process. Searches were performed on six electronic databases and a grey literature search was conducted on three databases. SB diagnosis was based on questionnaires or clinical examinations; no polysomnography exams were performed. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies...
April 16, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29660637/does-oral-administration-of-ketamine-accelerate-response-to-treatment-in-major-depressive-disorder-results-of-a-double-blind-controlled-trial
#8
Somaye Arabzadeh, Elham Hakkikazazi, Nazila Shahmansouri, Abbas Tafakhori, Alireza Ghajar, Morteza Jafarinia, Shahin Akhondzadeh
BACKGROUND: Major depressive disorder (MDD) exerts a high health and financial burden on society. The conventional pharmacotherapies for MDD are partially effective and the response to medication often starts with some delay. There are recent reports of antidepressant effects for oral ketamine. METHODS: We employed a double-blind controlled trial to examine the time course of the therapeutic effect of ketamine when combined with the conventional administration of sertraline...
February 22, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29660207/a-randomized-double-blind-comparison-of-aripiprazole-sertraline-combination-and-placebo-sertraline-combination-in-patients-with-major-depressive-disorder
#9
Kunitoshi Kamijima, Mahito Kimura, Kazuo Kuwahara, Yuri Kitayama, Yoshihiro Tadori
AIMS: This study compared the efficacy and safety of aripiprazole/sertraline combination (ASC) and placebo/sertraline combination (PSC) in patients with major depressive disorder (MDD) who showed an inadequate response to sertraline 100 mg/day. METHODS: The study comprised a screening period, an 8-week prospective treatment (single-blind sertraline 25-100 mg/day) period, and a 6-week double-blind treatment period. Patients with DSM-5-defined MDD were enrolled. Following the prospective treatment, non-responders were randomly assigned to the ASC group (aripiprazole 3-12 mg/day/sertraline 100 mg/day) or the PSC group (sertraline 100 mg/day)...
April 16, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29642692/noncardiac-chest-pain-a-2018-update
#10
Marilena Durazzo, Giuseppe Gargiulo, Rinaldo Pellicano
Noncardiac chest pain (NCCP) is defined as recurring, angina-like, chest pain of noncardiac origin. Studies have estimated that gastroesophageal reflux disease (GERD) is the most common contributing factor for NCCP. In patients with non-GERD related NCCP, esophageal motility disorders, and functional chest pain (FCP) of presumed esophageal origin are the main underlying mechanisms for symptoms. Epidemiologic studies show a high prevalence of panic disorder, anxiety and major depression in NCCP patients. The diagnostic esophageal workup starts only after that cardiac and pulmonary diseases have been ruled out...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29627920/advances-in-pharmacotherapy-of-late-life-depression
#11
REVIEW
John L Beyer, Kim G Johnson
This paper reviews recent research on late-life depression (LLD) pharmacotherapy, focusing on updated information for monotherapy and augmentation treatments. We then review new research on moderators of clinical response and how to use the information for improved efficacy. RECENT FINDINGS: A recent review shows that sertraline, paroxetine, and duloxetine were superior to placebo for the treatment of LLD. There is concern that paroxetine could have adverse outcomes in the geriatric population due to anticholinergic properties; however, studies show no increases in mortality, dementia risk, or cognitive measures...
April 7, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29622043/aripiprazole-induced-sleep-related-eating-disorder-a-case-report
#12
Nobuyuki Kobayashi, Masahiro Takano
BACKGROUND: Sleep-related eating disorder is characterized by parasomnia with recurrent episodes of nocturnal eating or drinking during the main sleep period. Several drugs, including atypical antipsychotics, induce sleep-related eating disorder. However, aripiprazole has not previously been associated with sleep-related eating disorder. CASE PRESENTATION: A 41-year-old Japanese man visited our clinic complaining of depression. The patient was treated with sertraline, which was titrated up to 100 mg for 4 weeks...
April 5, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29618006/dysfunction-of-serotoninergic-and-dopaminergic-neuronal-systems-in-the-antidepressant-resistant-impairment-of-social-behaviors-induced-by-social-defeat-stress-exposure-as-juveniles
#13
Sho Hasegawa, Yuriko Miyake, Akira Yoshimi, Akihiro Mouri, Hirotake Hida, Kiyofumi Yamada, Norio Ozaki, Toshitaka Nabeshima, Yukihiro Noda
Background: Extensive studies have been performed on the role of monoaminergic neuronal systems in rodents exposed to social defeat stress as adults. In the present study, we investigated the role of monoaminergic neuronal systems in the impairment of social behaviors induced by social defeat stress exposure as juveniles. Methods: Juvenile, male C57BL/6J mice were exposed to social defeat stress for 10 consecutive days. From 1 day after the last stress exposure, desipramine, sertraline, and aripiprazole, were administered for 15 days...
March 29, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29615391/differences-in-rates-of-switchbacks-after-switching-from-branded-to-authorized-generic-and-branded-to-generic-drug-products-cohort-study
#14
Rishi J Desai, Ameet Sarpatwari, Sara Dejene, Nazleen F Khan, Joyce Lii, James R Rogers, Sarah K Dutcher, Saeid Raofi, Justin Bohn, John Connolly, Michael A Fischer, Aaron S Kesselheim, Joshua J Gagne
OBJECTIVES: To compare rates of switchbacks to branded drug products for patients switched from branded to authorized generic drug products, which have the same active ingredients, appearance, and excipients as the branded product, with patients switched from branded to generic drug products, which have the same active ingredients as the branded product but may differ in appearance and excipients. DESIGN: Observational cohort study. SETTING: Private (a large commercial health plan) and public (Medicaid) insurance programs in the US...
April 3, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29607784/sertraline-induced-acute-eosinophilic-pneumonia
#15
Mayssan Muftah, Rama Nassri, Ammar Nassri, Paul Harford
Acute Eosinophilic Pneumonia (AEP) is a rare, potentially fatal disease often characterized by a short febrile illness, hypoxemic respiratory failure, diffuse pulmonary opacities and evidence of pulmonary eosinophilia. AEP can be idiopathic, but has documented associations with multiple drugs. We present the first case highlighting Sertraline specifically as a cause of drug-induced AEP in the English literature.
April 2, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29599988/contraceptives-as-possible-risk-factors-for-postpartum-depression-a-retrospective-study-of-the-food-and-drug-administration-adverse-event-reporting-system-2004-2015
#16
Megumi Horibe, Yuuki Hane, Junko Abe, Toshinobu Matsui, Yamato Kato, Natsumi Ueda, Sayaka Sasaoka, Yumi Motooka, Haruna Hatahira, Shiori Hasegawa, Yasutomi Kinosada, Hideaki Hara, Mitsuhiro Nakamura
Aim: Postpartum depression is a mood disorder that commonly affects women during the early postpartum period. The objective of this study was to analyse the association of postpartum depression with drugs (including contraceptive devices and implants) with spontaneously reported adverse events reported in the US Food and Drug Administration Adverse Event Reporting System database. Design: Retrospective study. Method: Reports of postpartum depression events between 2004-2015 were analysed with a reporting odds ratio (ROR) algorithm...
April 2018: Nursing Open
https://www.readbyqxmd.com/read/29595297/alcohol-cannabis-and-other-drug-use-engagement-and-outcome-in-ptsd-treatment
#17
Michele Bedard-Gilligan, Natalia Garcia, Lori A Zoellner, Norah C Feeny
The co-occurrence of posttraumatic stress disorder (PTSD) and substance use is related to poorer outcome and increased dropout from trauma-focused treatment. Investigating PTSD and substance use can inform the intervention approaches. Exploring cannabis use in particular is especially important because rates of cannabis use have been increasing with recent legalization trends. A better understanding of how substance use is associated with treatment processes and outcome for individuals with PTSD is needed to enhance care...
March 29, 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29588433/sexual-dysfunction-in-patients-with-antidepressant-treated-anxiety-or-depressive-disorders-a-pragmatic-multivariable-longitudinal-study
#18
S Preeti, S D Jayaram, A Chittaranjan
OBJECTIVE: To investigate early evolution, tolerability, and predictors of antidepressant-emergent sexual dysfunction in patients with anxiety or depressive disorder. METHODS: Patients with anxiety or depressive disorders who were prescribed antidepressant monotherapy (mirtazapine, sertraline, desvenlafaxine, escitalopram, or fluoxetine) at the discretion of the treating clinician were recruited from July 2012 to June 2014 from a hospital outpatient service. All were free of psychotropic medication for least 1 month...
March 2018: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/29577822/psychocardiological-disorder-and-brain-serotonin-after-comorbid-myocardial-infarction-and-depression-an-experimental-study
#19
Li-Jun Zhang, Mei-Yan Liu, Radhika Rastogi, Jessie N Ding
Objectives We investigated whether trimetazidine pretreatment can regulate central and peripheral serotonin (5-HT) in rats of myocardial infarction (MI) combined with depression. Methods Forty rats were randomly assigned to a sham operation group (n = 10) and a disease model group (n = 30). The sham operation group was pretreated with normal saline for 4 weeks. The disease model group was randomly assigned further into a negative control subgroup, a positive control subgroup, and a treatment subgroup - the groups received saline, sertraline, and trimetazidine pretreatment, respectively, for 4 weeks, then the rats were subjected to MI combined with depression...
March 26, 2018: Neurological Research
https://www.readbyqxmd.com/read/29570971/phenotypic-assessment-of-drug-metabolic-pathways-and-p-glycoprotein-in-patients-treated-with-antidepressants-in-an-ambulatory-setting
#20
Célia Lloret-Linares, Marija Bosilkovska, Youssef Daali, Marianne Gex-Fabry, Kyle Heron, Victor Bancila, Giorgio Michalopoulos, Nader Perroud, Hélène Richard-Lepouriel, Jean-Michel Aubry, Jules Desmeules, Marie Besson
OBJECTIVE: Drug-metabolizing enzymes (DMEs), such as cytochrome P450 (CYP) enzymes, and transporters have emerged as major determinants of variability in drug metabolism and response. This study investigated the association between CYP and P-glycoprotein activities and plasma antidepressant concentration in an outpatient clinical setting. Secondary outcomes were antidepressant efficacy and tolerance. We also describe phenotypes in patients treated with antidepressants and evaluate the tolerance of a minimally invasive phenotyping approach...
March 20, 2018: Journal of Clinical Psychiatry
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