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Pressure overload

Li Jin, Simei Sun, Yuhee Ryu, Zhe Hao Piao, Bin Liu, Sin Young Choi, Gwi Ran Kim, Hyung-Seok Kim, Hae Jin Kee, Myung Ho Jeong
Gallic acid is a trihydroxybenzoic acid found in tea leaves and some plants. Here, we report the effect of gallic acid on cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure and in primary rat cardiac fibroblasts, and compare the effects of gallic acid with those of drugs used in clinics. Gallic acid reduces cardiac hypertrophy, dysfunction, and fibrosis induced by transverse aortic constriction (TAC) stimuli in vivo and transforming growth factor β1 (TGF-β1) in vitro...
June 18, 2018: Scientific Reports
Martina Nassif, Frank van der Kley, Mohammad Abdelghani, Deborah N Kalkman, Rianne H A C M de Bruin-Bon, Berto J Bouma, Martin J Schalij, David R Koolbergen, Jan G P Tijssen, Barbara J M Mulder, Robbert J de Winter
Aims: Functional tricuspid regurgitation (TR) associated with atrial septal defects (ASDs) is frequently present due to right-sided volume-overload. Tricuspid valve (TV) repair is often considered in candidates for surgical ASD closure, and percutaneous TV repair is currently under clinical investigation. In this study, we develop a prediction model to identify patients with residual moderate/severe TR after percutaneous ASD closure. Methods and results: In this observational study, 172 adult patients (26% male, age 49 ± 17 years) with successful percutaneous ASD closure had pre- and post-procedural echocardiography...
June 13, 2018: European Heart Journal Cardiovascular Imaging
Tobias Dünnwald, Julia Held, Petru Balan, Otto Pecher, Thomas Zeiger, Frank Hartig, Erich Mur, Günter Weiss, Wolfgang Schobersberger
Tissue hypoxia contributes to the pathogenesis of several acute and chronic diseases. Hyperbaric oxygen therapy (HBO) and whole-body warming using low-temperature infrared technology (LIT) are techniques that might improve hypoxemia. Combining HBO and LIT as hyperbaric oxygen therapy combined with low-temperature infrared radiation (HBOIR) might be an approach that results in positive synergistic effects on oxygenation. LIT increases blood flow and could reduce HBO-induced vasoconstriction, and hyperoxia could compensate for the increased metabolic oxygen requirements mediated by LIT...
June 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Catharina Elizabeth Myburgh, Leoné Malan, Annemarie Wentzel, Jacobus De Wet Scheepers, Nicolaas Theodor Malan
BACKGROUND: Defensive coping (DefS) was associated with cardiovascular disease (CVD) susceptibility in Blacks. Whether coping strategies will associate with sub-clinical left ventricular hypertrophy (electrocardiographic-left ventricular hypertrophy [ECG-LVH] or Cornell product), cardiomyocyte injury and blood pressure (BP), is unclear. Therefore, we assessed relationships between ECG-LVH, cardiac troponin T (cTnT) and 24-hour BP in bi-ethnic groups when habitually utilising a certain coping style, and these groups when having a stress-related cTnT cut-point of 4...
May 31, 2018: Heart, Lung & Circulation
Frederik Beckhoff, Brunilda Alushi, Christian Jung, Eliano Navarese, Marcus Franz, Daniel Kretzschmar, Bernhard Wernly, Michael Lichtenauer, Alexander Lauten
Severe tricuspid regurgitation (TR) is a complex condition of the right ventricle (RV) and tricuspid valve apparatus and is frequently associated with symptomatic heart failure and a significant morbidity and mortality. In these patients, left heart pathologies lead to chronic pressure overload of the RV, eventually causing progressive RV dilatation and functional TR. Therefore, TR cannot be considered as isolated heart valve disease pathology but has to be understood and treated as one component of a complex structural RV pathology and is frequently also a marker of an advanced stage of cardiac disease...
2018: Frontiers in Cardiovascular Medicine
Gabriele G Schiattarella, Nicola Boccella, Roberta Paolillo, Fabio Cattaneo, Valentina Trimarco, Anna Franzone, Stefania D'Apice, Giuseppe Giugliano, Laura Rinaldi, Domenica Borzacchiello, Alessandra Gentile, Assunta Lombardi, Antonio Feliciello, Giovanni Esposito, Cinzia Perrino
Left ventricular hypertrophy (LVH) is a major contributor to the development of heart failure (HF). Alterations in cyclic adenosine monophosphate (cAMP)-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction occurring in LVH and HF. cAMP signals are received and integrated by a family of cAMP-dependent protein kinase A (PKA) anchor proteins (AKAPs), tethering PKA to discrete cellular locations. AKAPs encoded by the Akap1 gene (mitoAKAPs) promote PKA mitochondrial targeting, regulating mitochondrial structure and function, reactive oxygen species production, and cell survival...
2018: Frontiers in Physiology
Sujith Dassanayaka, Yuting Zheng, Andrew A Gibb, Timothy D Cummins, Lindsey A McNally, Kenneth R Brittian, Ganapathy Jagatheesan, Timothy N Audam, Bethany W Long, Robert E Brainard, Steven P Jones, Bradford G Hill
Pathological cardiac remodeling during heart failure is associated with higher levels of lipid peroxidation products and lower abundance of several aldehyde detoxification enzymes, including aldehyde dehydrogenase 2 (ALDH2). An emerging idea that could explain these findings concerns the role of electrophilic species in redox signaling, which may be important for adaptive responses to stress or injury. The purpose of this study was to determine whether genetically increasing ALDH2 activity affects pressure overload-induced cardiac dysfunction...
June 1, 2018: Redox Biology
Puneet Agarwal, Renu Agarwal
Disturbances of extracellular matrix (ECM) homeostasis cause increased aqueous outflow resistance leading to elevated intraocular pressure (IOP) in glaucomatous eyes. Therefore, restoration of ECM homeostasis is a rational approach to prevent disease progression. Since renin-angiotensin system (RAS) inhibition positively alters ECM homeostasis in cardiovascular pathologies involving pressure and volume overload, it is likely that RAS inhibitors reduce IOP primarily by restoring ECM homeostasis. Areas covered: Current evidence showing the presence of RAS components in ocular tissue and its role in regulating aqueous humor dynamics is briefly summarized...
June 8, 2018: Expert Opinion on Therapeutic Targets
Tik-Chee Cheng, Jennifer L Philip, Diana Marcela Tabima, Timothy A Hacker, Naomi C Chesler
Right ventricular failure (RVF) is the major cause of death in pulmonary hypertension. Recent studies have characterized changes in RV structure in RVF, including hypertrophy, fibrosis and abnormalities in mitochondria. Few if any studies have explored the relationships between these multi-scale structural changes and functional changes in RVF. Pulmonary artery banding (PAB) was used to induce RVF due to pressure overload in male rats. Eight-weeks post-surgery, terminal invasive measurements demonstrated RVF with decreased ejection fraction (70{plus minus}10% vs 45{plus minus}15%, Sham vs...
June 8, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Felix Wiedmann, Jan S Schulte, Bruna Gomes, Maria-Patapia Zafeiriou, Antonius Ratte, Franziska Rathjens, Edda Fehrmann, Beatrix Scholz, Niels Voigt, Frank Ulrich Müller, Dierk Thomas, Hugo A Katus, Constanze Schmidt
Understanding molecular mechanisms involved in atrial tissue remodeling and arrhythmogenesis in atrial fibrillation (AF) is essential for developing specific therapeutic approaches. Two-pore-domain potassium (K2P ) channels modulate cellular excitability, and TASK-1 (K2P 3.1) currents were recently shown to alter atrial action potential duration in AF and heart failure (HF). Finding animal models of AF that closely resemble pathophysiological alterations in human is a challenging task. This study aimed to analyze murine cardiac expression patterns of K2P channels and to assess modulation of K2P channel expression in murine models of AF and HF...
June 7, 2018: Basic Research in Cardiology
Yasushi Ohashi, Ken Sakai, Hiroki Hase, Nobuhiko Joki
Fluid volume overload is common and is associated with adverse outcomes in hemodialysis patients. Practicing physicians individually manage fluid volume balance in their dialysis patients according to blood pressure, interdialytic weight gain, cardiac function, nutritional status, and other comorbidities. However, accurate assessment of fluid volume status remains a concern. Indicators of dry weight target have been explored further with newer concepts and technologies. In general, total body water comprises approximately 50%-60% of adult body weight (range, 45%-75%), and water comprises 73...
June 6, 2018: Seminars in Dialysis
Qiancheng Wang, Zhenhuan Chen, Xiaobo Huang, Lin Chen, Baihe Chen, Yingqi Zhu, Shiping Cao, Wangjun Liao, Jianping Bin, Masafumi Kitakaze, Yulin Liao
Either angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor 1 blocker (ARB) attenuates cardiac remodeling. However, the overall molecular modulation of the reversing remodeling process in response to the ACEI or ARB treatment is not yet well determined. In this study, we examined whether gene expressions are modulated by ACEI (temocapril), ARB (olmesartan) or both in a murine model with transverse aortic constriction (TAC) and confirm whether periostin is a target gene of olmesartan in mice with myocardial infarction (MI)...
May 15, 2018: Oncotarget
Nathalia Bernardes, Danielle da Silva Dias, Filipe Fernandes Stoyell-Conti, Janaina de Oliveira Brito-Monzani, Christiane Malfitano, Elia Garcia Caldini, Luis Ulloa, Susana Francisca Llesuy, Maria-Cláudia Irigoyen, Kátia De Angelis
This study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7, 15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time...
June 5, 2018: Scientific Reports
Mathew J Platt, Jason S Huber, Nadya Romanova, Keith R Brunt, Jeremy A Simpson
A growing proportion of heart failure (HF) patients present with impairments in both ventricles. Experimental pressure-overload (i.e., transverse aortic constriction, TAC) induces left ventricle (LV) hypertrophy and failure, as well as right ventricle (RV) dysfunction. However, little is known about the coordinated progression of biventricular dysfunction that occurs in TAC. Here we investigated the time course of systolic and diastolic function in both the LV and RV concurrently to improve our understanding of the chronology of events in TAC...
2018: Frontiers in Physiology
José F Ek-Vitorín, Tasha K Pontifex, Janis M Burt
Connexin 43 (Cx43), a gap junction protein seemingly fit to support cardiac impulse propagation and synchronic contraction, is phosphorylated in normoxia by casein kinase 1 (CK1). However, during cardiac ischemia or pressure overload hypertrophy, this phosphorylation fades, Cx43 abundance decreases at intercalated disks and increases at myocytes' lateral borders, and the risk of arrhythmia rises. Studies in wild-type and transgenic mice indicate that enhanced CK1-phosphorylation of Cx43 protects from arrhythmia, while dephosphorylation precedes arrhythmia vulnerability...
June 4, 2018: International Journal of Molecular Sciences
Michael Mutlak, Michal Schlesinger-Laufer, Tali Haas, Rona Shofti, Nimer Ballan, Yair E Lewis, Mor Zuler, Yaniv Zohar, Lilac H Caspi, Izhak Kehat
BACKGROUND: Chronic pressure overload and a variety of mediators induce concentric cardiac hypertrophy. When prolonged, cardiac hypertrophy culminates in decreased myocardial function and heart failure. Activation of the extracellular signal-regulated kinase (ERK) is consistently observed in animal models of hypertrophy and in human patients, but its role in the process is controversial. METHODS: We generated transgenic mouse lines with cardiomyocyte restricted overexpression of intrinsically active ERK1, which similar to the observations in hypertrophy is phosphorylated on both the TEY and the Thr207 motifs and is overexpressed at pathophysiological levels...
May 24, 2018: International Journal of Cardiology
James C Barton, Jackson Clayborn Barton, Ronald T Acton
BACKGROUND: We sought to determine associations with insulin resistance (IR) and metabolic syndrome (MetS) in African Americans. METHODS: We studied African American adults without diabetes in a postscreening examination. Participants included Cases: transferrin saturation (TS) >50% and serum ferritin (SF) >300 μg/L (M), and TS >45% and SF >200 μg/L (F), regardless of HFE genotype; and Controls: TS/SF 25th to 75th percentiles and HFE wt/wt (wild type)...
May 31, 2018: Metabolic Syndrome and related Disorders
Vaia D Raikou, Despina Kyriaki
Background: Intradialytic hypertension was associated with a high mortality risk. We examined the relationship between intradialytic hypertension and metabolic disorders in hemodialysis treatment patients. Methods: We studied 76 patients in online hemodiafiltration. Dialysis adequacy was defined by Kt / V for urea. Normalized protein catabolic rate (nPCR), as a marker of protein intake, was calculated. Sodium removal was determined as percent sodium removal. Metabolic acidosis was determined by serum bicarbonate less than 22 mmol/L...
2018: International Journal of Hypertension
Masaki Kajimoto, Muhammad Nuri, Nancy G Isern, Isabelle Robillard-Frayne, Christine Des Rosiers, Michael A Portman
BACKGROUND: Surgical palliation or repair of complex congenital heart disease in early infancy can produce right ventricular (RV) pressure overload, often leading to acute hemodynamic decompensation. The mechanisms causing this acute RV dysfunction remain unclear. We tested the hypothesis that the immature right ventricle lacks the ability to modify substrate metabolism in order to meet increased energy demands induced by acute pressure overloading. METHODS AND RESULTS: Twenty-two infant male mixed breed Yorkshire piglets were randomized to a sham operation (Control) or pulmonary artery banding yielding >2-fold elevation over baseline RV systolic pressure...
May 30, 2018: Journal of the American Heart Association
Van K Ninh, Elia Ec El Hajj, Alan J Mouton, Milad C El Hajj, Nicholas W Gilpin, Jason D Gardner
BACKGROUND: Alcohol is among the most commonly abused drugs worldwide and affects many organ systems, including the heart. Alcoholic cardiomyopathy is characterized by a dilated cardiac phenotype with extensive hypertrophy and extracellular matrix (ECM) remodeling. We have previously shown that chronic ethanol administration accelerates the progression to heart failure in a rat model of volume overload. However, the mechanism by which this decompensation occurs is unknown. For this study, we hypothesized that chronic ethanol administration would prevent compensatory hypertrophy and cardiac remodeling in a rodent model of pressure overload (PO)...
May 30, 2018: Alcoholism, Clinical and Experimental Research
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