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https://www.readbyqxmd.com/read/29683463/a-closed-chest-model-to-induce-transverse-aortic-constriction-in-mice
#1
Lars Eichhorn, Christina Katharina Weisheit, Christopher Gestrich, Konrad Peukert, Georg Daniel Duerr, Muhammad Ajmal Ayub, Felix Erdfelder, Florian Stöckigt
Research on cardiac hypertrophy and heart failure is frequently based on pressure overload mouse models induced by TAC. The standard procedure is to perform a partial thoracotomy to visualize the transverse aortic arch. However, the surgical trauma caused by the thoracotomy in open-chest models changes the respiratory physiology as the ribs are dissected and left unattached after chest closure. To prevent this, we established a minimally invasive, closed chest approach via lateral thoracotomy. Herein we approach the aortic arch via the 2nd intercostal space without entering the chest cavities, leaving the mouse with a less traumatic injury to recover from...
April 5, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29678661/role-of-heat-shock-transcription-factor-1-hsf1-upregulated-macrophage-in-ameliorating-pressure-overload-induced-heart-failure-in-mice
#2
Peizhao Du, Yaowei Chang, Fangjie Dai, Chunyan Wei, Qi Zhang, Jiming Li
In order to explore the role of macrophages in HSF1-mediated alleviation of heart failure, mice model of pressure overload-induced heart failure was established using transverse aortic constriction (TAC). Changes in cardiac function and morphology were studied in TAC and SHAM groups using ultrasonic device, tissue staining, electron microscopy, real-time quantitative polymerase chain reaction (RT-QPCR), and Western blotting. We found that mice in the TAC group showed evidence of impaired cardiac function and aggravation of fibrosis on ultrasonic and histopathological examination when compared to those in the SHAM group...
April 17, 2018: Gene
https://www.readbyqxmd.com/read/29677206/synergistic-interaction-between-a-pde5-inhibitor-sildenafil-and-a-new-adenosine-a2a-receptor-agonist-lassbio-1359-improves-pulmonary-hypertension-in-rats
#3
Allan K Alencar, Fábio I Carvalho, Ananssa M Silva, Sabrina T Martinez, Jorge A Calasans-Maia, Carlos M Fraga, Eliezer J Barreiro, Gisele Zapata-Sudo, Roberto T Sudo
INTRODUCTION: Pulmonary hypertension (PH) is characterized by enhanced pulmonary vascular resistance, which causes right ventricle (RV) pressure overload and results in right sided heart failure and death. This work investigated the effectiveness of a combined therapy with PDE5 inhibitor (PDE5i) and a new adenosine A2A receptor (A2AR) agonist in mitigating monocrotaline (MCT) induced PH in rats. METHODS: An in vitro isobolographic analysis was performed to identify possible synergistic relaxation effect between sildenafil and LASSBio 1359 in rat pulmonary arteries (PAs)...
2018: PloS One
https://www.readbyqxmd.com/read/29674378/the-caval-sphincter-in-cetaceans-and-its-predicted-role-in-controlling-venous-flow-during-a-dive
#4
Margo A Lillie, A Wayne Vogl, Stephen Raverty, Martin Haulena, William A McLellan, Garry B Stenson, Robert E Shadwick
A sphincter on the inferior vena cava can protect the heart of a diving mammal from overload when elevated abdominal pressures increase venous return, yet sphincters are reported incompetent or absent in some cetacean species. We previously hypothesized that abdominal pressures are elevated and pulsatile in fluking cetaceans, and that collagen is deposited on the diaphragm according to pressure levels to resist deformation. Here we tested the hypothesis that cetaceans generating high abdominal pressures need a more robust sphincter than those generating low pressures...
April 19, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29666587/cardioprotective-effects-of-qishenyiqi-dripping-pills-on-transverse-aortic-constriction-induced-heart-failure-in-mice
#5
Guoran Ruan, Haojin Ren, Chi Zhang, Xiaogang Zhu, Chao Xu, Liyue Wang
QiShenYiQi dripping pills (QSYQ), a traditional Chinese medicine, are commonly used to treat coronary heart disease, and QSYQ was recently approved as a complementary treatment for ischemic heart failure in China. However, only few studies reported on whether QSYQ exerts a protective effect on heart failure induced by pressure overload. In this study, we explored the role of QSYQ in a mouse model of heart failure induced by transverse aortic constriction (TAC). Twenty-eight C57BL/6J mice were divided into four groups: Sham + NS group, Sham + QSYQ group, TAC + NS group, and TAC + QSYQ group...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29666426/cardiac-hypertrophy-limits-infarct-expansion-after-myocardial-infarction-in-mice
#6
Siiri E Iismaa, Ming Li, Scott Kesteven, Jianxin Wu, Andrea Y Chan, Sara R Holman, John W Calvert, Ahtesham Ul Haq, Amy M Nicks, Nawazish Naqvi, Ahsan Husain, Michael P Feneley, Robert M Graham
We have previously demonstrated that adult transgenic C57BL/6J mice with CM-restricted overexpression of the dominant negative W v mutant protein (dn-c-kit-Tg) respond to pressure overload with robust cardiomyocyte (CM) cell cycle entry. Here, we tested if outcomes after myocardial infarction (MI) due to coronary artery ligation are improved in this transgenic model. Compared to non-transgenic littermates (NTLs), adult male dn-c-kit-Tg mice displayed CM hypertrophy and concentric left ventricular (LV) hypertrophy in the absence of an increase in workload...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29664809/microrna-19a-b-3p-protect-the-heart-from-hypertension-induced-pathological-cardiac-hypertrophy-through-pde5a
#7
Kun Liu, Qiongyu Hao, Jie Wei, Gong-Hao Li, Yong Wu, Yun-Feng Zhao
AIM: PDE5A is a leading factor contributing to cGMP signaling and cardiac hypertrophy. However, microRNA-mediated posttranscriptional regulation of PDE5A has not been reported. The aim of this study is to screen the microRNAs that are able to regulate PDE5A and explore the function of the microRNAs in cardiac hypertrophy and remodeling. METHODS AND RESULTS: Although miR-19a/b-3p (microRNA-19a-3p and microRNA-19b-3p) have been reported to be differentially expressed during cardiac hypertrophy, the direct targets and the functions of this microRNA family for regulation of cardiac hypertrophy have not yet been investigated...
April 16, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29663506/new-classification-of-geometric-ventricular-patterns-in-severe-aortic-stenosis-could-it-be-clinically-useful
#8
Concetta Di Nora, Eugenio Cervesato, Iulian Cosei, Andreea Ravasel, Bogdan A Popescu, Concetta Zito, Scipione Carerj, Francesco Antonini-Canterin, Andreea C Popescu
BACKGROUND: In severe aortic stenosis, different left ventricle (LV) remodeling patterns as a response to pressure overload have distinct hemodynamic profiles, cardiac function, and outcomes. The most common classification considers LV relative wall thickness and LV mass index to create 4 different groups. A new classification including also end-diastolic volume index has been recently proposed. AIM: To describe the prevalence of the newly identified remodeling patterns in patients with severe aortic stenosis and to evaluate their clinical relevance according to symptoms...
April 16, 2018: Echocardiography
https://www.readbyqxmd.com/read/29663292/the-potential-role-of-sglt2-inhibitors-in-the-treatment-of-type-1-diabetes-mellitus
#9
Hadi Fattah, Volker Vallon
Type 1 diabetes mellitus is a difficult disease to treat due to the relative paucity of therapeutic options other than injectable insulin. The latter, however, can induce hypoglycemia, which has been linked to enhanced cardiovascular risk. Sodium glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral anti-hyperglycemic medications that do not increase the hypoglycemia risk and are US Food and Drug Administration (FDA) approved in type 2 diabetes mellitus. SGLT2 inhibitors may also be of benefit in type 1 diabetic patients, in addition to insulin, although they have not yet been approved for this indication...
April 16, 2018: Drugs
https://www.readbyqxmd.com/read/29660505/gcn2-deficiency-ameliorates-doxorubicin-induced-cardiotoxicity-by-decreasing-cardiomyocyte-apoptosis-and-myocardial-oxidative-stress
#10
Yue Wang, Tong Lei, Juntao Yuan, Yongguang Wu, Xiyue Shen, Junling Gao, Wei Feng, Zhongbing Lu
The clinical use of doxorubicin for cancer therapy is limited by its cardiotoxicity, which involves cardiomyocyte apoptosis and oxidative stress. Previously, we showed that general control nonderepressible 2 (GCN2), an eukaryotic initiation factor 2α (eIF2α) kinase, impairs the ventricular adaptation to chronic pressure overload by affecting cardiomyocyte apoptosis. However, the impact of GCN2 on Dox-induced cardiotoxicity has not been investigated. In the present study, we treated wild type (WT) and Gcn2-/- mice with four intraperitoneal injections (5 mg/kg/week) to induce cardiomyopathy...
April 7, 2018: Redox Biology
https://www.readbyqxmd.com/read/29657372/targeted-interventions-in-critically-ill-children-with-severe-dengue
#11
Suchitra Ranjit, Gokul Ramanathan, Balasubramaniam Ramakrishnan, Niranjan Kissoon
Background: The World Health Organization guidelines provide suggestions on early recognition and treatment of severe dengue (SD); however, mortality in this group can be high and is related both to disease severity and the treatment complications. Subjects and Methods: In this prospective observational study, we report our results where standard therapy (ST) was enhanced by Intensive Care Unit (ICU) supportive measures that have proven beneficial in other conditions that share similar pathophysiology of capillary leak and fluid overload...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29655822/clinical-spectrum-and-management-of-heart-failure-in-hypertrophic-cardiomyopathy
#12
REVIEW
Barry J Maron, Ethan J Rowin, James E Udelson, Martin S Maron
Heart failure (HF), characterized by excessive exertional dyspnea, is a common complication within the broad clinical spectrum of hypertrophic cardiomyopathy (HCM). HF has become an increasingly prominent management issue with the reduction in sudden deaths due to use of implantable defibrillators in this disease. Exertional dyspnea ranges in severity from mild to severe (New York Heart Association functional classes II to IV) and not uncommonly becomes refractory to medical management, leading to progressive disability, but largely in the absence of pulmonary congestion and volume overload requiring hospitalization...
April 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29655684/protective-role-and-mechanism-of-snakegourd-peel-against-myocardial-infarction-in-rats
#13
Guanlin Yang, Dongyu Min, Junwei Yan, Ming Yang, Guijun Lin
BACKGROUND: Injection of snakegourd peel (SP), an herb used in traditional Chinese medicine, is used to treat coronary artery disease and stable angina in China. However, its therapeutic role and mechanism of action for the treatment of myocardial infarction (MI) is not fully understood. PURPOSE: The present study was designed to investigate the effect of SP on MI-induced cardiac injury and elucidate its underlying molecular mechanisms. METHODS: To create an in vivo model of MI, we ligated the left coronary artery of Wistar rats...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29642696/periprocedural-and-perioperatory-management-of-patients-with-tricuspid-valve-disease
#14
Fabrizio Monaco, Ambra L DI Prima, Monica DE Luca, Gaia Barucco, Alberto Zangrillo
Tricuspid regurgitation (TR) is a common valvular lesion which may affect morbidity and mortality. It can be related to an intrinsic abnormality of the tricuspid valve leaflets (organic) or secondary to annular dilatation (functional). Often organic and functional TR coexist in the same patient. A long standing TR is associated with ascites, congestive hepatopathy, peripheral edema, renal failure, and abdominal fullness which significantly affect the outcome. In particular, the perioperative course may be complicated due to both the presence of comorbidities and the development of a severe postoperative right ventricle (RV) dysfunction...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29627971/how-to-tackle-congestion-in-acute-heart-failure
#15
Pieter Martens, Wilfried Mullens
Acute heart failure is a common complication of chronic heart failure and is associated with a high risk for subsequent mortality and morbidity. In 90% of case acute heart failure is the resultant of congestion, a manifestation of fluid build-up due to increased filling pressures. As residual congestion at discharge following an acute heart failure episodes is one of the strongest predictors of poor outcome, the goal of therapy should be to resolve congestion completely. Important to comprehend is that increased cardiovascular filling pressures are not solely the resultant of intravascular volume excess but can also be induced by a decreased venous capacitance...
April 11, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29627295/deficiency-of-aldose-reductase-exacerbates-early-pressure-overload-induced-cardiac-dysfunction-and-autophagy-in-mice
#16
Shahid P Baba, Deqing Zhang, Mahavir Singh, Sujith Dassanayaka, Zhengzhi Xie, Ganapathy Jagatheesan, Jingjing Zhao, Virginia K Schmidtke, Kenneth R Brittian, Michael L Merchant, Daniel J Conklin, Steven P Jones, Aruni Bhatnagar
Pathological cardiac hypertrophy is associated with the accumulation of lipid peroxidation-derived aldehydes such as 4-hydroxy-trans-2-nonenal (HNE) and acrolein in the heart. These aldehydes are metabolized via several pathways, of which aldose reductase (AR) represents a broad-specificity route for their elimination. We tested the hypothesis that by preventing aldehyde removal, AR deficiency accentuates the pathological effects of transverse aortic constriction (TAC). We found that the levels of AR in the heart were increased in mice subjected to TAC for 2 weeks...
April 5, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29626503/hsf1-deficiency-accelerates-the-transition-from-pressure-overload-induced-cardiac-hypertrophy-to-heart-failure-through-endothelial-mir-195a-3p-mediated-impairment-of-cardiac-angiogenesis
#17
Shijun Wang, Jian Wu, Jieyun You, Hongyu Shi, Xiaoyu Xue, Jiayuan Huang, Lei Xu, Guoliang Jiang, Lingyan Yuan, Xue Gong, Haiyan Luo, Junbo Ge, Zhaoqiang Cui, Yunzeng Zou
Heat shock transcription factor 1 (HSF1) deficiency aggravates cardiac remodeling under pressure overload. However, the mechanism is still unknown. Here we employed microRNA array analysis of the heart tissue of HSF1-knockout (KO) mice to investigate the potential roles of microRNAs in pressure overload-induced cardiac remodeling under HSF-1 deficiency, and the profiles of 478 microRNAs expressed in the heart tissues of adult HSF1-KO mice were determined. We found that the expression of 5 microRNAs was over 2-fold higher expressed in heart tissues of HSF1-KO mice than in those of wild-type (WT) control mice...
April 4, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29621764/right-ventricular-functions-in-pulmonary-thromboembolism
#18
Tarik Yildirim, Fatih Akın, Ibrahim Altun, Seda Yildirim, Ozcan Basaran, Mustafa Soylu
<br><br>this is a letter to editor We have read with great interest the paper entitled 'Subclinical Atherosclerosis in Patients with Prior Pulmonary Thromboembolism' Buyukterzi et al.1 is very important study. We have some suggestions about this trial. Firstly there are several echocardiographic parameters are available to determine right ventricular functions. Fractional area change (FAC), tricuspit annular plane systolic excursion (TAPSE), tissue Doppler derived right ventricular systolic excursion velocity S', strain and strain rate are the major determiner of right ventricular systolic functions...
April 5, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29621314/sildenafil-ameliorates-right-ventricular-early-molecular-derangement-during-left-ventricular-pressure-overload
#19
Yousuke Imai, Taro Kariya, Masaki Iwakiri, Yoshitsugu Yamada, Eiki Takimoto
Right ventricular (RV) dysfunction following left ventricular (LV) failure is associated with poor prognosis. RV remodeling is thought initiated by the increase in the afterload of RV due to secondary pulmonary hypertension (PH) to impaired LV function; however, RV molecular changes might occur in earlier stages of the disease. cGMP (cyclic guanosine monophosphate)-phosphodiesterase 5 (PDE5) inhibitors, widely used to treat PH through their pulmonary vasorelaxation properties, have shown direct cardiac benefits, but their impacts on the RV in LV diseases are not fully determined...
2018: PloS One
https://www.readbyqxmd.com/read/29620626/acupotomy-for-calcaneodynia-a-systematic-review-protocol
#20
Yifeng Shen, Qiaoyin Zhou, Zuyun Qiu, Yan Jia, Shiliang Li
BACKGROUND: Calcaneodynia customarily induces inferior heel pain, specialists believe that the pain is principally caused by acute or chronic injury due to the plantar fascia from accumulative overload pressure. Acupotomy has been widely used to treat calcaneodynia. But its efficiency has not been scientifically and methodically evaluated. The aim of this study is to evaluate the efficacy and safety of the acupotomy treatment in patients with calcaneodynia. METHODS: Relevant randomized controlled trials in 6 databases (PubMed, Embase, and Cochrane Library, Chinese literature databases, Chinese Biomedical Literature Database [CBM], China National Knowledge Infrastructure [CNKI], and Wanfang Database)...
April 2018: Medicine (Baltimore)
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