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Soft tissue filler

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https://www.readbyqxmd.com/read/28715577/device-safety-implications-of-the-clinical-data-leading-to-us-food-and-drug-administration-approval-of-soft-tissue-fillers-a-systematic-review
#1
Mary E Lohman, Comeron W Ghobadi, Shuai Xu
Importance: The US Food and Drug Administration (FDA) recently issued a safety warning regarding soft-tissue fillers (STFs) based on the risk of blindness and facial necrosis. Objective: To examine the quality of evidence leading to FDA approval of STFs. Evidence Review: All original approvals for STFs were mined using the publicly available FDA database. The Cochrane Collaboration's risk of bias assessment tool was applied to all randomized clinical trials (RCTs)...
July 13, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28702968/in-vitro-evaluation-of-collagen-production-on-human-fibroblasts-treated-with-hyaluronic-acid-peg-cross-linked-with-micromolecules-of-calcium-hydroxyapatite-in-low-concentration
#2
N Zerbinati, R Rauso, P Gonzalez, M Cherubino, E D'Este, A Calligaro, S Sommatis, C Maccario, R Mocchi
Neauvia Stimulate® is a biocompatible, injectable hyaluronic acid (HA) filler (26 mg/ml) PEG cross-linked with 1% of calcium hydroxyapatite (CaHA) for facial soft-tissue augmentation that provides volume to tissues, followed by a process of neocollagenesis for improving skin quality. The aim of the present study is to evaluate the possible modulation of collagen synthesis after treating human fibroblasts cultured in vitro with the product (Lot. 160517-26-1/2 PEG). The experimental model proposed, despite being an in vitro system, allows the derivation of useful information to predict the possible activity of the product in further in vivo application...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702187/procedure-applications-and-outcomes-of-autologous-fat-grafting
#3
REVIEW
Francesco Simonacci, Nicolò Bertozzi, Michele Pio Grieco, Eugenio Grignaffini, Edoardo Raposio
OBJECTIVE: To systematically review the procedure, applications, and outcomes of autologous fat grafting, a promising technique with various clinical applications. PATIENTS AND METHODS: Literature review of publications concerning autologous fat grafting. RESULTS: Since its introduction, lipofilling has become increasingly popular; however, its results are variable and unpredictable. Several modifications have been made to the procedures of fat harvesting, processing, and injecting...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28691479/effect-of-platelet-reach-plasma-on-fibroblast-primary-culture-gene-expression-evaluation
#4
V Candotto, A Palmieri, F Cura, F J Silvestre, D Lauritano, R M Gaudio, A Baj, A B Giannì
To correct skin imperfections, aesthetic medicine today makes use of injectable dermal fillers that allow filling skin by increasing the volume of soft tissue. Currently, there are many fillers usable for their excellent biocompatibility and low allergic reactions that ensure good results and good compliance. Among these, the most widely used filler is Human Plasma, obtained by centrifugation from patient blood and processed through cycles of centrifugation and heating, until it becomes a gel. In this work, we evaluated the effect of the Plasma on fibroblasts behavior in terms of cell viability, survival, growth and collagen production...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28665851/demarcative-necrosis-along-previous-laceration-line-after-filler-injection
#5
Jong-Lim Kim, Jin Yong Shin, Si-Gyun Roh, Nae-Ho Lee
In recent years, fillers have been widely used for soft tissue augmentation. Although they are generally considered to be safe, many complications have been reported to date. Nose and nasolabial fold augmentations with fillers can lead to an implementation of nasal skin necrosis, possibly caused by intravascular embolism and/or extravascular compression. Herein, we present a case of a successfully treated patient who experienced skin necrosis after an injection of dermal fillers into the nasolabial fold. Interestingly, we discovered that the patient had experienced a laceration 8 years ago around the area in which the filler was injected...
June 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28657430/tumescent-anesthesia-for-reducing-pain-swelling-and-ecchymosis-during-polycaprolactone-filler-injections-in-the-face
#6
JongSeo Kim
PCL filler can be injected in two major ways to control pain. One is such method involves mixing 0.3cc of PCL filler with lidocaine, and the other is the method introduced in this report, which involves pre-injection with a tumescent solution . It is hard to reduce pain effectively with pre-mixing PCL filler with lidocaine because there may be not enough time to act lidocaine solution effect immediately for pain control. Pre-mixing method change properties of original filler especially the property of CMC portion...
June 28, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28652795/minimal-recovery-time-needed-to-return-to-social-engagement-following-nasolabial-fold-correction-with-hyaluronic-acid-fillers-produced-with-xpreshan-technology
#7
Arthur Swift, Erika von Grote, Brandie Jonas, Alessandra Nogueira
INTRODUCTION: The appeal of hyaluronic acid fillers for facial soft tissue augmentation is attributable to both an immediate aesthetic effect and relatively short recovery time. Although recovery time is an important posttreatment variable, as it impacts comfort with appearance and perceived treatment benefit, it is not routinely evaluated. Natural-looking aesthetic outcomes are also a primary concern for many patients. MATERIALS AND METHODS: A single-center, noncomparative study evaluated the time (in hours) until subjects return to social engagement (RtSE) following correction of moderate and severe nasolabial folds (NLFs) with RR (Restylane(®) Refyne)(®) and RD (Restylane Defyne), respectively...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28643010/discussion-nonsurgical-facial-rejuvenation-outcomes-and-safety-of-neuromodulator-and-soft-tissue-filler-procedures-performed-in-a-resident-cosmetic-clinic
#8
Devra B Becker
No abstract text is available yet for this article.
June 22, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28628686/off-face-usage-of-poly-l-lactic-acid-for-body-rejuvenation
#9
Ahmad Jabbar, Suleima Arruda, Neil Sadick
<p>Injectable soft-tissue augmentation agents have become popular alternatives to surgical procedures for the aging face and body. In contrast to temporary, space-occupying replacement fillers such as collagen-based and hyaluronic acid products, poly-l-lactic acid (PLLA) has been demonstrated to gradually promotes deposition of collagen via a biostimulatory response, with therapeutic effects lasting approximately two years. In 2004, the FDA approved its use for rejuvenation of facial contours secondary to lipoatrophy associated with antiretroviral therapy for HIV infection...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28585321/delayed-onset-filler-complication-two-case-reports-and-literature-review
#10
Hyeree Kim, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
Soft tissue augmentation by fillers has become a popular cosmetic tool to offer rejuvenation and aesthetic improvement. Its results are comparable to those previously achieved only by plastic surgery. However, marked increase of filler procedures is associated with a great number of complications. Complications associated with filler injection might have early onset (within days) or late onset (after weeks to years). Delayed complications include infections, foreign body granulomatous reaction, migration of filler material, persistent discoloration, and scarring...
June 6, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28576053/antibacterial-sno2-nanorods-as-efficient-fillers-of-poly-propylene-fumarate-co-ethylene-glycol-biomaterials
#11
Ana M Díez-Pascual, Angel L Díez-Vicente
Antibacterial and biocompatible SnO2 nanorods have been easily synthesized through a hydrothermal process with the aid of a cationic surfactant, and incorporated as nanoreinforcements in poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) copolymer crosslinked with N-vinyl-pyrrolidone (NVP) by sonication and thermal curing. The nanorods were randomly and individually dispersed inside the P(PF-co-EG) network, and noticeably increased the thermal stability, hydrophilicity, degree of crystallinity, protein absorption capability as well as stiffness and strength of the matrix, whilst decreased its level of porosity and biodegradation rate...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28571065/cheek-and-chin-implants-to-enhance-facelift-results
#12
Russell W H Kridel, Sagar Patel
The traditional rhytidectomy addresses facial and neck aging as it relates to soft tissue laxity. The modern volumetric facelift provides optimal results by addressing not only skin laxity but also the loss of volume secondary to tissue atrophy and bony resorption. While multiple techniques including fat grafting, dermal fillers, and tissue resuspension are used to correct the tissue loss, alloplastic midface augmentation remains the most permanent method. In our practice we often address midface cheek hollowness or atrophy with the placement of submalar implants at the time of rhytidectomy...
June 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28547293/nonsurgical-facial-rejuvenation-outcomes-and-safety-of-neuromodulator-and-soft-tissue-filler-procedures-performed-in-a-resident-cosmetic-clinic
#13
Ali A Qureshi, Rajiv P Parikh, Ketan Sharma, Terence M Myckatyn, Marissa M Tenenbaum
BACKGROUND: The ability to perform nonsurgical facial rejuvenation procedures is a core competency requirement for plastic surgery residents. However, limited data exist on training models to achieve competency in nonsurgical facial rejuvenation and on outcomes of these procedures performed by residents. The purpose here is to evaluate patient-reported outcomes and safety of nonsurgical facial rejuvenation procedures performed by plastic surgery residents. METHODS: We prospectively enrolled 50 patients undergoing neuromodulator and/or soft-tissue filler injections in a resident cosmetic clinic between April and August 2016...
May 25, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28525415/effects-of-collagenase-digestion-and-stromal-vascular-fraction-supplementation-on-volume-retention-of-fat-grafts
#14
Jonathan B Olenczak, Scott A Seaman, Kant Y Lin, Angela Pineros-Fernandez, Catherine E Davis, Lisa S Salopek, Shayn M Peirce, Patrick S Cottler
OBJECTIVE: The use of autologous fat as a soft tissue filler has increased over the past decade in both reconstructive and aesthetic surgeries. Enhancement of autologous fat grafts with the addition of the stromal vascular fraction (SVF) has been reported to improve long-term volume retention. Stromal vascular fraction is most commonly isolated using enzymatic digestion, but it is unknown what effect the digestion process has on the adipocytes and SVF cells that comprise the graft. Some clinicians have reported use of enzymatically digested fat grafts to alter the physical properties of the tissue in specialized applications...
June 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28510696/autologous-adipose-derived-tissue-matrix-part-ii-implantation-biology
#15
Stephen A Schendel
Background: In part 1 of this study it was shown that liposuctioned fat could be a sufficient source of autologous collagen for use as a filler or in reconstruction. The collagen composition in liposuctioned fat was shown to form a cross-linked helical matrix composed of types II, III, and IV. Additionally, viable adipocytes and fibroblasts among other cells were found. Objectives: The purpose of this research was to study the biology of this matrix after subsequent implantation compared to Juvederm (Allergan, Parsippany, NJ) common soft tissue filler...
May 16, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28510634/autologous-adipose-derived-tissue-matrix-part-i-biologic-characteristics
#16
Stephen A Schendel
Background: Autologous collagen is an ideal soft tissue filler and may serve as a matrix for stem cell implantation and growth. Procurement of autologous collagen has been limited, though, secondary to a sufficient source. Liposuction is a widely performed and could be a source of autologous collagen. Objectives: The amount of collagen and its composition in liposuctioned fat remains unknown. The purpose of this research was to characterize an adipose-derived tissue-based product created using ultrasonic cavitation and cryo-grinding...
May 16, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28449190/consensus-statement-on-prevention-and-management-of-adverse-effects-following-rejuvenation-procedures-with-hyaluronic-acid-based-fillers
#17
REVIEW
W G Philipp-Dormston, D Bergfeld, B M Sommer, G Sattler, S Cotofana, P Snozzi, U Wollina, K P J Hoffmann, C Salavastru, K Fritz
Facial fillers play an important role in the correction of facial changes associated with ageing. They offer quick treatments in the outpatient setting with minimal subsequent downtime that provide predictable, natural-looking, long-lasting results. Adverse reactions after hyaluronic acid injections tend to be mild or moderate and rather temporary. However, as with all injected or implanted biomaterials, severe adverse events can occur and patients must be fully informed of potential risks prior to undergoing treatment...
April 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28448315/suggested-injection-zone-for-soft-tissue-fillers-in-the-temple
#18
Jean Carruthers, Shannon Humphrey, Katie Beleznay, Alastair Carruthers
No abstract text is available yet for this article.
April 12, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28445360/facial-danger-zones-techniques-to-maximize-safety-during-soft-tissue-filler-injections
#19
Jack F Scheuer, David A Sieber, Ronnie A Pezeshk, Andrew A Gassman, Carey F Campbell, Rod J Rohrich
Given the short recovery and immediate results, facial fillers have become a popular alternative to surgical rejuvenation of the face. Reported complications arising from facial filler injections include erythema, tissue loss, blindness, stroke, and even death. In this article, the authors describe their anatomically based techniques to minimize risk and maximize safety when injecting in the facial danger zones, including the glabella/brow, temporal region, perioral region, nasolabial fold, nose, and infraorbital region...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28441304/suggested-injection-zone-for-soft-tissue-fillers-in-the-temple
#20
Jean Carruthers, Shannon Humphrey, Katie Beleznay, Alastair Carruthers
No abstract text is available yet for this article.
May 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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