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https://www.readbyqxmd.com/read/28741276/the-use-of-a-biphasic-calcium-phosphate-in-a-maxillary-sinus-floor-elevation-procedure-a-clinical-radiological-histological-and-histomorphometric-evaluation-with-9-and-12-month-healing-times
#1
W F Bouwman, N Bravenboer, J W F H Frenken, C M Ten Bruggenkate, E A J M Schulten
BACKGROUND: This study evaluates the clinical, radiological, histological, and histomorphometric aspects of a fully synthetic biphasic calcium phosphate (BCP) (60% hydroxyapatite and 40% ß-tricalcium phosphate), used in a human maxillary sinus floor elevation (MSFE) procedure with 9- and 12-month healing time. METHODS: A unilateral MSFE procedure, using 100% BCP, was performed in two series of five patients with healing times of 9 and 12 months respectively. Clinical and radiological parameters were measured up to 5 years postoperatively...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28740855/aldose-reductase-inhibitor-protects-against-hyperglycemic-stress-by-activating-nrf2-dependent-antioxidant-proteins
#2
Kirtikar Shukla, Pabitra Bikash Pal, Himangshu Sonowal, Satish K Srivastava, Kota V Ramana
We have shown earlier that pretreatment of cultured cells with aldose reductase (AR) inhibitors prevents hyperglycemia-induced mitogenic and proinflammatory responses. However, the effects of AR inhibitors on Nrf2-mediated anti-inflammatory responses have not been elucidated yet. We have investigated how AR inhibitor fidarestat protects high glucose- (HG-) induced cell viability changes by increasing the expression of Nrf2 and its dependent phase II antioxidant enzymes. Fidarestat pretreatment prevents HG (25 mM)-induced Thp1 monocyte viability...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28739610/silicone-implant-incompatibility-syndrome-siis-in-a-57-year-old-woman-with-unilateral-silicone-breast-implant
#3
Juliane Schierbeck, Jesper Rømhild Davidsen, Sanne Grindsted Nielsen, Camilla Bille
Since the 1960s, silicone implants have been used for breast augmentations, both cosmetically and in reconstructive surgery. Tissue exposed to silicone can react with multiple adverse advents. Autoimmune/inflammatory syndrome induced by adjuvants due to silicone exposure from ruptured silicone implants can lead to different interstitial lung manifestations predominantly with granuloma evolvement, leading to the so-called silicone implant incompatibility syndrome (SIIS). This case describes a 57-year-old woman with multiple lung infiltrations and a left-sided breast implant...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28739500/breast-implant-capsule-associated-squamous-cell-carcinoma-a-report-of-two-cases
#4
Daniel L Olsen, Gary L Keeney, Beiyun Chen, Daniel W Visscher, Jodi M Carter
The use of prosthetic implants for breast augmentation has become commonplace. While implants do not increase the risk of conventional mammary carcinoma, they are rarely associated with anaplastic large cell lymphoma. We report two cases of breast implant capsule-associated squamous cell carcinoma with poor clinical outcomes. Both patients (56-year-old female and 81-year-old female) had long-standing implants (>25years) and presented with acute unilateral breast enlargement. In both cases, squamous cell carcinoma arose in (focally dysplastic) squamous epithelium-lined breast implant capsules, and widely invaded surrounding breast parenchyma or chest wall...
July 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28738773/pro-angiogenic-molecules-for-therapeutic-angiogenesis
#5
Selvaprithiviraj Vignesh, Sankar Deepthi, Amirthalingam Sivashanmugam, Sowmya Srinivasan, Rangasamy Jayakumar
Angiogenesis, the formation of new functional blood vessels from the preexisting vasculature, is a highly orchestrated event, tightly controlled by a convoluted combination of biochemical and biomolecular signals. Therapeutic angiogenesis is a clinical approach to trigger neovascularization, which requires balance of multiple proangiogenic factors. It is of prime importance as it augments neovascularization, thereby enhancing tissue oxygen exchange which is crucial to several ischemia related pathophysiological conditions...
July 24, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28738532/genipin-attenuates-cisplatin-induced-nephrotoxicity-by-counteracting-oxidative-stress-inflammation-and-apoptosis
#6
Eglal Mahgoub, Shanmugam Muthu Kumaraswamy, Kamal Hassan Kader, Balaji Venkataraman, Shreesh Ojha, Ernest Adeghate, Mohanraj Rajesh
Cisplatin (CP) is a potent and widely used chemotherapeutic agent. However, the clinical benefits of CP are compromised because it elicits nephrotoxicity and ototoxicity. In this study, we investigated the nephroprotective effects of the phytochemical genipin (GP) isolated from the gardenia (Gardenia jasminoides) fruit, using a murine model of CP-induced nephropathy. GP pretreatment attenuated the CP-induced renal tissue injury by diminishing the serum blood urea nitrogen, creatinine, and cystatin C levels, as well as those of kidney injury molecule-1...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28737515/cell-biology-of-spinal-cord-injury-and-repair
#7
Timothy M O'Shea, Joshua E Burda, Michael V Sofroniew
Spinal cord injury (SCI) lesions present diverse challenges for repair strategies. Anatomically complete injuries require restoration of neural connectivity across lesions. Anatomically incomplete injuries may benefit from augmentation of spontaneous circuit reorganization. Here, we review SCI cell biology, which varies considerably across three different lesion-related tissue compartments: (a) non-neural lesion core, (b) astrocyte scar border, and (c) surrounding spared but reactive neural tissue. After SCI, axon growth and circuit reorganization are determined by neuron-cell-autonomous mechanisms and by interactions among neurons, glia, and immune and other cells...
July 24, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28736870/alveolar-bone-resorption-after-primary-tooth-loss-has-a-negative-impact-on-straightforward-implant-installation-in-patients-with-agenesis-of-the-lower-second-premolar
#8
Kristina Bertl, Michael H Bertl, Patrick Heimel, Maria Burt, André Gahleitner, Andreas Stavropoulos, Christian Ulm
OBJECTIVES: To compare the alveolar bone dimensions in patients with lower second premolar (P2) agenesis prior to and after primary molar loss on CT scans, and assess the possibility for straightforward implant placement. METHODS: Alveolar bone dimensions were evaluated on 150 mandibular CT scans in three groups: (i) agenesis of P2, with the primary tooth in situ, and regularly erupted first premolar (P1) and molar (M1) (AW); (ii) agenesis of P2, without the primary tooth in situ for ≥3 m, but regularly erupted P1 and M1 (AWO); and (iii) P1, P2, and M1 regularly erupted (CTR)...
July 23, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28736687/tissue-engineered-tendon-for-enthesis-regeneration-in-a-rat-rotator-cuff-model
#9
Michael J Smietana, Pablo Moncada-Larrotiz, Ellen M Arruda, Asheesh Bedi, Lisa M Larkin
Healing of rotator cuff (RC) injuries with current suture or augmented scaffold techniques fails to regenerate the enthesis and instead forms a weaker fibrovascular scar that is prone to subsequent failure. Regeneration of the enthesis is the key to improving clinical outcomes for RC injuries. We hypothesized that the utilization of our tissue-engineered tendon to repair either an acute or a chronic full-thickness supraspinatus tear would regenerate a functional enthesis and return the biomechanics of the tendon back to that found in native tissue...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28736658/3d-reconstruction-of-cystoscopy-videos-for-comprehensive-bladder-records
#10
Kristen L Lurie, Roland Angst, Dimitar V Zlatev, Joseph C Liao, Audrey K Ellerbee Bowden
White light endoscopy is widely used for diagnostic imaging of the interior of organs and body cavities, but the inability to correlate individual 2D images with 3D organ morphology limits its utility for quantitative or longitudinal studies of disease physiology or cancer surveillance. As a result, most endoscopy videos, which carry enormous data potential, are used only for real-time guidance and are discarded after collection. We present a computational method to reconstruct and visualize a 3D model of organs from an endoscopic video that captures the shape and surface appearance of the organ...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28736606/mandibular-bone-regeneration-after-bone-slat-technique
#11
Salvatore D'Amato, Gianpaolo Tartaro, Angelo Itro, Mario Santagata
BACKGROUND: The reconstruction of alveolar ridges for implant placement is still a challenging surgical procedure, especially in the case of extensive vertical and horizontal bone atrophy. OBJECTIVE: The objective of the present study was to evaluate the quantity and quality of newly regenerated bone; clinically by means of direct clinical measuring, ridges augmented by autogenous cortical bone associated with autogenous particulate bone graft in the posterior lower jaw defect...
January 2017: Annali di Stomatologia
https://www.readbyqxmd.com/read/28732690/cromolyn-chitosan-nanoparticles-as-a-novel-protective-approach-for-colorectal-cancer
#12
Tarek K Motawi, Shohda A El-Maraghy, Aliaa Nabil ElMeshad, Omnia M Nady, Olfat A Hammam
Colorectal cancer is the third most common cancer in the world. Cromolyn is a mast cell stabilizer and was proposed as an anticancer agent; however its high polarity limits its bioavailability by rapid washing from the body. We formulated 10 cromolyn chitosan nanoparticles (CCSNPs)(1) following ionic gelation technique to improve its bioavailability and investigated the protective anticancer effect of the optimum formula against colorectal cancer in dimethylhydrazine-induced model in rats. Rats were divided into seven groups, group-1: normal control, group-2: cromolyn control, group-3: CCSNPs control, groups-4 to 7 received dimethylhydrazine for 16 weeks to induce colorectal cancer...
July 18, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28732356/the-circrna-interactome-innovative-hallmarks-of-the-intra-and-extracellular-radiation-response
#13
Valerie Bríd O'Leary, Jan Smida, Martina Matjanovski, Corinna Brockhaus, Klaudia Winkler, Simone Moertl, Saak Victor Ovsepian, Michael John Atkinson
Generated by Quaking (QKI), circular RNAs (circRNAs) are newly recognised non-coding RNA (ncRNA) members characterised by tissue specificity, increased stability and enrichment within exosomes. Studies have shown that ionizing radiation (IR) can influence ncRNA transcription. However, it is unknown whether circRNAs or indeed QKI are regulated by IR. Microarray circRNA profiling and next generation sequencing revealed that circRNA expression was altered by low and medium dose exposure sourced predominantly from genes influencing the p53 pathway...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28731675/sustained-release-of-a-peptide-based-matrix-metalloproteinase-2-inhibitor-to-attenuate-adverse-cardiac-remodeling-and-improve-cardiac-function-following-myocardial-infarction
#14
Zhaobo Fan, Minghuan Fu, Zhaobin Xu, Bo Zhang, Zhihong Li, Haichang Li, Xinyu Zhou, Xuanyou Liu, Yunyan Duan, Pei-Hui Lin, Pu Duann, Xiaoyun Xie, Jianjie Ma, Zhenguo Liu, Jianjun Guan
Following myocardial infarction (MI), degradation of extracellular matrix (ECM) by upregulated matrix metalloproteinases (MMPs) especially MMP-2 decreases tissue mechanical properties, leading to cardiac function deterioration. Attenuation of cardiac ECM degradation at the early stage of MI has the potential to preserve tissue mechanical properties, resulting in cardiac function increase. Yet the strategy for efficiently preventing cardiac ECM degradation remains to be established. Current preclinical approaches have shown limited efficacy due to low drug dosage allocated to the heart tissue, dose-limiting side effects, and cardiac fibrosis...
July 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28731160/adipose%C3%A2-derived-stem-cells-and-hyaluronic-acid-based-gel-compatibility-studied-in-vitro
#15
Jiayan Guo, Shu Guo, Yuxin Wang, Yanqiu Yu
Minimally invasive aesthetic and cosmetic procedures have increased in popularity. Injectable dermal fillers provide soft tissue augmentation, improve facial rejuvenation and wrinkles, and correct tissue defects. To investigate the use of adipose‑derived stem cells integrated with a hyaluronic acid based gel as a dermal filler, the present study used cytotoxicity studies, proliferation studies, adipogenic and osteogenic differentiation, apoptosis assays and scanning electron microscopy. Although hyaluronic acid induced low levels of apoptosis in adipose‑derived stem cells, its significantly promoted proliferation of adipose‑derived stem cells...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28730531/comparing-different-tissue-engineered-repair-materials-for-the-treatment-of-pelvic-organ-prolapse-and-urinary-incontinence-which-material-is-better
#16
Xiaojuan Wang, Yisong Chen, Zhongyong Fan, Keqin Hua
INTRODUCTION AND HYPOTHESIS: Synthetic non-absorbable meshes are widely used to augment surgical repair of pelvic organ prolapse (POP) and stress urinary incontinence (SUI), but these meshes are associated with serious complications. This study compares the attachment and extracellular matrix (ECM) production of adipose-derived stem cells (ADSCs) on different biodegradable nanomaterials to develop tissue engineered repair materials. METHODS: Rat ADSCs were isolated and cultured on electrospun poly-L-lactic acid (PLA) and electrospun poly(L-lactide)-trimethylene carbonate-gycolide (PLTG) terpolymers for 1 and 2 weeks...
July 20, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28728332/skin-necrosis-with-oculomotor-nerve-palsy-due-to-a-hyaluronic-acid-filler-injection
#17
Jae Il Lee, Seok Joo Kang, Hook Sun
Performing rhinoplasty using filler injections, which improve facial wrinkles or soft tissues, is relatively inexpensive. However, intravascular filler injections can cause severe complications, such as skin necrosis and visual loss. We describe a case of blepharoptosis and skin necrosis caused by augmentation rhinoplasty and we discuss the patient's clinical progress. We describe the case of a 25-year-old female patient who experienced severe pain, blepharoptosis, and decreased visual acuity immediately after receiving a filler injection...
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28727998/enrichment-of-endogenous-fractalkine-and-anti-inflammatory-cells-via-aptamer-functionalized-hydrogels
#18
Syed Faaiz Enam, Jack R Krieger, Tarun Saxena, Brian E Watts, Claire E Olingy, Edward A Botchwey, Ravi V Bellamkonda
Early recruitment of non-classical monocytes and their macrophage derivatives is associated with augmented tissue repair and improved integration of biomaterial constructs. A promising therapeutic approach to recruit these subpopulations is by elevating local concentrations of chemoattractants such as fractalkine (FKN, CX3CL1). However, delivering recombinant or purified proteins is not ideal due to their short half-lives, suboptimal efficacy, immunogenic potential, batch variabilities, and cost. Here we report an approach to enrich endogenous FKN, obviating the need for delivery of exogenous proteins...
July 10, 2017: Biomaterials
https://www.readbyqxmd.com/read/28727462/tridimensional-reconstruction-of-a-complex-iatrogenic-defect-using-orthodontic-forced-eruption-and-minimally-invasive-bone-grafting
#19
Ernesto A Lee
As the use of dental implants has become more common, so has the frequency of complications and unforeseen outcomes. This article describes the treatment of a complex iatrogenic defect secondary to a failed implant (No. 7) and multiple bone-grafting attempts in the maxillary anterior region. The patient's revealing smile line and high-risk circumstances demanded the use of an interdisciplinary treatment approach with high potential for predictable esthetic results. Forced eruption was performed to restore the alveolar height deficit and develop the compromised hard and soft tissues around teeth Nos...
July 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28727461/risk-indicators-and-prevention-of-implant-soft-tissue-complications-interproximal-papillae-loss-and-midfacial-implant-mucosal-recessions
#20
James Mailoa, Richard J Miron, Hom-Lay Wang
Achieving a long-term esthetic implant restoration in the maxillary anterior area is sometimes unpredictable. This article reviews several risk indicators of implant mucosal recession and loss of interproximal papillae, and how to prevent these risks. Results obtained from the literature suggest that the following factors are strongly related to implant soft-tissue complications: buccally positioned implant placement, a thin gingival biotype, lack of an adequate amount of keratinized mucosa, implant placement after ridge augmentation procedures, an increased distance of tooth bone peak to the contact point, and an inadequate horizontal implant-tooth distance...
July 2017: Compendium of Continuing Education in Dentistry
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