keyword
https://read.qxmd.com/read/38450747/paliperidone-poisoning-and-measurable-plasma-concentrations-2-5%C3%A2-years-after-last-administered-dose-a-case-report
#21
Mariam Nersesjan, Maria Wagner, Kim Peder Dalhoff, Tonny Studsgaard Petersen, Søren Bøgevig, Henrik Horwitz
We report a poisoning with paliperidone palmitate, a once-monthly, long-acting injectable antipsychotic. The patient suffered from deep sedation and dystonia. She had been treated with extended release intramuscular paliperidone for several years and had received her last injection 8 days prior to admission. The plasma paliperidone was nearly five times higher than the upper reference range. Paliperidone is a substrate of p-glycoprotein and we therefore aimed to increase its elimination by inducing p-glycoprotein through treatment with St John's wort...
March 7, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38449476/pregabalin-adjuventia-helped-risperidone-induced-extrapyramidal-syndrome-and-augmented-antipsychotic-response-in-an-adolescent-with-schizophrenia
#22
Ahmed Naguy, Saxby Pridmore, Bibi Alamiri
Here, authors report on an interesting case of early-onset of schizophrenia where adjunctive pregabalin alleviated risperidone-induced pseudoparkinsonism, helped with insomnia and agitation and boosted antipsychotic response with great tolerability. We wager that gabapentenoids can be a viable option in the niche of psychopharmacotherapy of schizophrenia in CAP population.
March 4, 2024: Psychopharmacology Bulletin
https://read.qxmd.com/read/38449474/new-onset-prolonged-psychosis-following-synthetic-cannabinoid-use-in-an-older-patient-a-case-report
#23
Ahmed Alhassan, Srihari R Prahad, Bradley G Burk, Rachel E Fargason, Badari Birur
Synthetic cannabinoids (SCs), a class of new psychoactive substances (NPS) commonly known as "spice," has rapidly gained popularity and become the most ubiquitous NPS on the illegitimate drug market. SCs, unlike natural cannabis (NC), are not controlled by international drug conventions, posing a significant risk to public health. These substances are easily accessible, relatively inexpensive, and challenging to detect in routine drug screenings. The existing literature provides strong evidence of an association between NC use and psychosis, but there is significantly less data on SC psychosis...
March 4, 2024: Psychopharmacology Bulletin
https://read.qxmd.com/read/38436168/genotoxic-and-genoprotective-effects-of-some-antipsychotic-drugs-methylphenidate-and-atomoxetine-on-human-lymphocytes-and-hepg2-cells
#24
JOURNAL ARTICLE
S K Sezer, S Yuksel, I Ucuz
OBJECTIVE: Aripiprazole, risperidone, atomoxetine, and methylphenidate are drugs commonly prescribed for many psychiatric conditions and can be used alone or in combination in children and adolescents. This study aimed to investigate comparatively the possible genotoxic effects or genoprotective potentials of these drugs on human lymphocytes and HepG2 cells. MATERIALS AND METHODS: Cytotoxicity analysis was performed with the cell viability test on human lymphocytes and HepG2 cells, and half-maximal inhibitory concentration (IC50) values of the drugs were determined, and three different doses (¼ IC50, ½ IC50, and IC50) were applied for genetic analysis...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38428310/gynura-procumbens-and-selected-metabolites-amelioration-of-depressive-like-behaviors-in-mice-and-risperidone-induced-hyperprolactinemia-in-rats
#25
JOURNAL ARTICLE
Si-Yu Zhai, Hong-Wei Gu, Cong Wang, Yu-Sang Li, He-Bin Tang
Gynura procumbens (Lour.) Merr., utilized in traditional Chinese medicine, is known for its liver-protective, liver-soothing, and depression-alleviating properties. This research examines the antidepressant and anti-hyperprolactinemia potentials of an ethanol extract from G. procumbens stems (EEGS) and specific metabolites. To model depression and hyperprolactinemia, chronic unpredictable mild stress (CUMS) was induced in mice and risperidone was administered to rats, respectively. Treatments involved administering low (5 mg/kg), medium (25 mg/kg), and high (125 mg/kg) doses of EEGS and certain metabolites to both models...
February 29, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38421437/the-polymorphisms-of-candidate-pharmacokinetic-and-pharmacodynamic-genes-and-their-pharmacogenetic-impacts-on-the-effectiveness-of-risperidone-maintenance-therapy-among-saudi-children-with-autism
#26
JOURNAL ARTICLE
Sireen Abdul Rahim Shilbayeh, Iman Sharaf Adeen, Ayman Shawqi Alhazmi, Haya Aljurayb, Rana Saad Altokhais, Nourah Alhowaish, Khawlah Essa Aldilaijan, Mostafa Kamal, Anwar Mansour Alnakhli
BACKGROUND: Antipsychotics, including risperidone (RIS), are frequently indicated for various autism spectrum disorder (ASD) manifestations; however, "actionable" PGx testing in psychiatry regarding antipsychotic dosing and selection has limited applications in routine clinical practice because of the lack of standard guidelines, mostly due to the inconsistency and scarcity of genetic variant data. The current study is aimed at examining the association of RIS effectiveness, according to ABC-CV and CGI indexes, with relevant pharmacokinetics (PK) and pharmacodynamics (PD) genes...
February 29, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38418646/neurexin1%C3%AE-knockout-in-rats-causes-aberrant-social-behaviour-relevance-for-autism-and-schizophrenia
#27
JOURNAL ARTICLE
E J Marijke Achterberg, Barbara Biemans, Louk J M J Vanderschuren
RATIONALE: Genetic and environmental factors cause neuropsychiatric disorders through complex interactions that are far from understood. Loss-of-function mutations in synaptic proteins like neurexin1α have been linked to autism spectrum disorders (ASD) and schizophrenia (SCZ), both characterised by problems in social behaviour. Childhood social play behaviour is thought to facilitate social development, and lack of social play may precipitate or exacerbate ASD and SCZ. OBJECTIVE: To test the hypothesis that an environmental insult acts on top of genetic vulnerability to precipitate psychiatric-like phenotypes...
February 29, 2024: Psychopharmacology
https://read.qxmd.com/read/38408281/network-meta-analysis-indicates-superior-effects-of-omega-3-polyunsaturated-fatty-acids-in-preventing-the-transition-to-psychosis-in-individuals-at-clinical-high-risk
#28
JOURNAL ARTICLE
Chengfeng Chen, Yongyan Deng, Yuling Li, Meiting Zhang, Tong Yu, Kun Xie, Wuyou Bao, Peiying Li, Ling Sun, Tianhong Zhang, Yikang Zhu, Bin Zhang
BACKGROUND: The efficacy of pharmacological and nutritional interventions in individuals at clinical high risk for psychosis (CHR-P) remains elusive. This study aims to investigate the efficacy of pharmacological and nutritional interventions in CHR-P and whether these interventions can enhance the efficacy of psychological treatments. METHODS: We systematically reviewed data from five databases until July 24, 2021: PubMed, Web of Science, EMBASE, China National Knowledge Infrastructure, and WanFang Data...
February 26, 2024: International Journal of Neuropsychopharmacology
https://read.qxmd.com/read/38399382/risperidone-decreases-expression-of-serotonin-receptor-2a-5-ht2a-and-serotonin-transporter-sert-but-not-dopamine-receptors-and-dopamine-transporter-dat-in-pbmcs-from-patients-with-schizophrenia
#29
JOURNAL ARTICLE
Samantha Alvarez-Herrera, Mauricio Rosel Vales, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Yvonne Flores-Medina, José Luis Maldonado-García, Ricardo Saracco-Alvarez, Raúl Escamilla, Lenin Pavón
Dopamine and serotonin receptors and transporters play an essential role in the pathophysiology of schizophrenia; changes in their expression have been reported in neurons and leukocytes. Each antipsychotic induces a unique pattern in leukocyte function and phenotype. However, the use of polytherapy to treat schizophrenia makes it challenging to determine the specific effects of risperidone on peripheral blood mononuclear cells (PBMCs). The aim of this study was to evaluate the changes in the expression of D3 , D5 , DAT, 5-HT2A , and SERT in PBMCs from healthy volunteers (HV), drug-naive patients with schizophrenia (PWS), drug-free PWS, and PWS treated with risperidone for up to 40 weeks using quantitative PCR...
January 28, 2024: Pharmaceuticals
https://read.qxmd.com/read/38399366/a-new-intervention-for-implementation-of-pharmacogenetics-in-psychiatry-a-description-of-the-psy-pgx-clinical-study
#30
JOURNAL ARTICLE
Teuntje A D Pelgrim, Alexandra Philipsen, Allan H Young, Mario Juruena, Ester Jimenez, Eduard Vieta, Marin Jukić, Erik Van der Eycken, Urs Heilbronner, Ramona Moldovan, Martien J H Kas, Raj R Jagesar, Markus M Nöthen, Per Hoffmann, Noam Shomron, Laura L Kilarski, Thérèse van Amelsvoort, Bea Campforts, The Psy-PGx Consortium, Roos van Westrhenen
(1) Background Pharmacological treatment for psychiatric disorders has shown to only be effective in about one-third of patients, as it is associated with frequent treatment failure, often because of side effects, and a long process of trial-and-error pharmacotherapy until an effective and tolerable treatment is found. This notion emphasizes the urgency for a personalized medicine approach in psychiatry. (2) Methods This prospective patient- and rater-blinded, randomized, controlled study will investigate the effect of dose-adjustment of antidepressants escitalopram and sertraline or antipsychotics risperidone and aripiprazole according to the latest state-of-the-art international dosing recommendations for CYP2C19 and CYP2D6 metabolizer status in patients with mood, anxiety, and psychotic disorders...
January 23, 2024: Pharmaceuticals
https://read.qxmd.com/read/38399363/population-pharmacodynamic-models-of-risperidone-on-panss-total-scores-and-prolactin-levels-in-schizophrenia
#31
JOURNAL ARTICLE
Zhiwei Huang, Lei Zhang, Yan Li, Yimin Yu, Yifeng Shen, Xiujia Sun, Kun Lou, Hongmei Luo, Zhibin Meng, Huafang Li, Yumei Wei
Currently, research predominantly focuses on evaluating clinical effects at specific time points while neglecting underlying patterns within the treatment process. This study aims to analyze the dynamic alterations in PANSS total scores and prolactin levels in patients with schizophrenia treated with risperidone, along with the influencing covariates. Using data from an 8-week randomized, double-blind, multicenter clinical trial, a population pharmacodynamic model was established for the PANSS total scores of and prolactin levels in patients treated with risperidone...
January 23, 2024: Pharmaceuticals
https://read.qxmd.com/read/38388986/an-open-label-study-to-assess-monthly-risperidone-injections-180-mg-following-switch-from-daily-oral-risperidone-6-mg-in-stable-schizophrenic-patients
#32
JOURNAL ARTICLE
David P Walling, Sunita N Shinde, Janice M Pogoda, Jahnavi Kharidia, Celine M Laffont
BACKGROUND AND OBJECTIVE: Long-acting injectable antipsychotics have shown benefits over oral medications with reduced hospitalization rates and improved health-related quality of life. RBP-7000 (PERSERIS® ) is a monthly risperidone formulation (90 or 120 mg) for the treatment of schizophrenia administered by subcutaneous abdominal injection. The objective of this study was to assess a higher dose of 180 mg RBP-7000 and an alternate injection site. METHODS: Following stabilization on 6 mg/day (3 mg twice daily) oral risperidone, clinically stable schizophrenic participants received 3 monthly doses of 180 mg RBP-7000 in the abdomen followed by a fourth monthly dose of 180 mg RBP-7000 in the upper arm (each dose administered as two 90-mg injections)...
February 22, 2024: Clinical Drug Investigation
https://read.qxmd.com/read/38387714/modulation-of-neuronal-morphology-by-antipsychotic-drug-involvement-of-serotonin-receptor-7
#33
JOURNAL ARTICLE
Luisa Speranza, Marta Molinari, Floriana Volpicelli, Enza Lacivita, Marcello Leopoldo, Salvatore Pulcrano, Gian Carlo Bellenchi, Carla Perrone Capano, Marianna Crispino
Antipsychotic drugs (APDs) are the primary pharmacological treatment for schizophrenia, a complex disorder characterized by altered neuronal connectivity. Atypical or second-generation antipsychotics, such as Risperidone (RSP) and Clozapine (CZP) predominantly block dopaminergic D2 and serotonin receptor 2A (5-HT2A) neurotransmission. Both compounds also exhibit affinity for the 5-HT7R, with RSP acting as an antagonist and CZP as an inverse agonist. Our study aimed to determine whether RSP and CZP can influence neuronal morphology through a 5-HT7R-mediated mechanism...
February 20, 2024: Brain Research
https://read.qxmd.com/read/38387603/unraveling-the-influence-of-age-iq-education-and-negative-symptoms-on-neurocognitive-performance-in-schizophrenia-a-conditional-inference-tree-analysis
#34
JOURNAL ARTICLE
Xenia M Hart, Yasue Mitsukura, Robert R Bies, Hiroyuki Uchida
INTRODUCTION: The complex nature of neurocognitive impairment in schizophrenia has been discussed in light of the mixed effects of antipsychotic drugs, psychotic symptoms, dopamine D2 receptor blockade, and intelligence quotient (IQ). These factors have not been thoroughly examined before. METHODS: This study conducted a comprehensive re-analysis of the CATIE data using machine learning techniques, in particular Conditional Inference Tree (CTREE) analysis, to investigate associations between neurocognitive functions and moderating factors such as estimated trough dopamine D2 receptor blockade with risperidone, olanzapine, or ziprasidone, Positive and Negative Syndrome Scale (PANSS), and baseline IQ in 573 patients with schizophrenia...
February 22, 2024: Pharmacopsychiatry
https://read.qxmd.com/read/38385986/effect-of-the-nfib-rs28379954-t-c-polymorphism-on-cyp2d6-catalyzed-metabolism-of-solanidine
#35
JOURNAL ARTICLE
Robert Løvsletten Smith, Birgit M Wollmann, Elisabet Størset, Hasan Çağın Lenk, Kevin S O'Connell, Marianne Kringen Kristiansen, Magnus Ingelman-Sundberg, Espen Molden
Cytochrome P450 2D6 (CYP2D6) is important for metabolism of 20%-25% of all clinically used drugs. Many known genetic variants contribute to the large interindividual variability in CYP2D6 metabolism, but much is still unexplained. We recently described that nuclear factor 1B (NFIB) regulates hepatic CYP2D6 expression with the minor allele of NFIB rs28379954 T>C significantly increasing CYP2D6-mediated risperidone metabolism. In this study, we investigated the effect of NFIB T>C on metabolism of solanidine, a dietary CYP2D6 substrate...
February 2024: Clinical and Translational Science
https://read.qxmd.com/read/38385262/the-use-of-psychotropic-medications-in-autistic-individuals-21%C3%A2-years-and-younger-in-western-australia-a-preliminary-investigation
#36
JOURNAL ARTICLE
Roselyne Bulonza, Kim Watkins, Richard Parsons, Bruce Sunderland, Andrew Whitehouse, Rima Caccetta
Prescriptions and use of medications to treat mental health conditions in young autistic populations are inconsistent worldwide. This makes it hard to compare findings from international studies to the Australian autistic population, where there are limited relevant studies. Apart from risperidone, there are no other medications specified for direct use in autistic persons. This study aims to gain initial broad understanding of the use of medications, commonly prescribed for mental health conditions, specifically by autistics under the age of 21 years...
February 22, 2024: Autism: the International Journal of Research and Practice
https://read.qxmd.com/read/38380489/-the-value-of-re-evaluation-and-thorough-family-history-taking-for-the-diagnostic-work-up-of-chorea
#37
JOURNAL ARTICLE
J J Luykx, E van Duijn, B Geerdinck, E Burgers, H P H Kremer, R Veenhuizen
The differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease...
2024: Tijdschrift Voor Psychiatrie
https://read.qxmd.com/read/38377522/influence-of-cyp2d6-metabolizer-status-on-risperidone-and-paliperidone-tolerability-in-children-and-adolescents
#38
REVIEW
Amarachi A Kanu, Michelle M Johnston, Ethan A Poweleit, Samuel E Vaughn, Jeffrey R Strawn, Laura B Ramsey
Background: Risperidone and, to a lesser extent, paliperidone are metabolized by CYP2D6; however, there are limited data related to variation in CYP2D6 phenotypes and the tolerability of these medications in children and adolescents. Furthermore, the impact of CYP2D6 on the association of risperidone and paliperidone with hyperprolactinemia in youth is not well understood. Methods: A retrospective chart review was performed in psychiatrically hospitalized children and adolescents prescribed risperidone ( n  = 263, age = 3-18 years, mean age = 13 ± 3 years, 49% female) or paliperidone ( n  = 124, age = 5-18 years, mean age = 15 ± 2 years, 44% female) who had CYP2D6 genotyping performed as part of routine care...
February 2024: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/38375040/exploratory-focused-pharmacogenetic-testing-reveals-novel-markers-associated-with-risperidone-pharmacokinetics-in-saudi-children-with-autism
#39
JOURNAL ARTICLE
Sireen Abdul Rahim Shilbayeh, Iman Sharaf Adeen, Ezzeldeen Hasan Ghanem, Haya Aljurayb, Khawlah Essa Aldilaijan, Fatimah AlDosari, Abeer Fadda
Background: Autism spectrum disorders (ASDs) encompass a broad range of phenotypes characterized by diverse neurological alterations. Genomic studies have revealed considerable overlap between the molecular mechanisms implicated in the etiology of ASD and genes involved in the pharmacokinetic (PK) and pharmacodynamic (PD) pathways of antipsychotic drugs employed in ASD management. Given the conflicting data originating from candidate PK or PD gene association studies in diverse ethnogeographic ASD populations, dosage individualization based on "actionable" pharmacogenetic (PGx) markers has limited application in clinical practice...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38370988/clozapine-withdrawal-catatonia-a-case-report
#40
Amit Jagtiani, Tarika Nagi, Raghu Gandhi, Abid Rizvi
Catatonia, which is associated with gamma-aminobutyric acid (GABA) hypoactivity, often responds robustly to benzodiazepines. It has been reported to be a consequence of abrupt discontinuation of clozapine, an antipsychotic used for treatment-resistant schizophrenia. Clozapine discontinuation, sometimes necessitated by medical concerns, can carry the risk of adverse outcomes, including catatonia. We present the case of a 66-year-old African-American male with schizoaffective disorder (depressive subtype) and a complex medical history...
January 2024: Curēus
keyword
keyword
4837
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.