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https://www.readbyqxmd.com/read/29453686/antipsychotic-prescribing-and-safety-monitoring-practices-in-children-and-youth-a-population-based-study-in-alberta-canada
#1
Wenxin Chen, Monica Cepoiu-Martin, Antonia Stang, Diane Duncan, Chris Symonds, Lara Cooke, Tamara Pringsheim
BACKGROUND AND OBJECTIVE: Antipsychotic medication use has steadily increased in Canada, with an expansion in the profile of users and the diagnoses for which they are used. The use of antipsychotics is associated with a number of adverse effects for which routine monitoring is recommended. The objectives of this study were to determine the most common diagnoses associated with antipsychotic use in children in Alberta, Canada and the proportion who receive recommended laboratory tests for adverse effects...
February 16, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29453005/post-mortem-quetiapine-concentrations-in-hair-segments-of-psychiatric-patients-correlation-between-hair-concentration-dose-and-concentration-in-blood
#2
Kamilla Nyborg Günther, Sys Stybe Johansen, Marie Katrine Klose Nielsen, Petra Wicktor, Jytte Banner, Kristian Linnet
Drug analysis in hair is useful when seeking to establish drug intake over a period of months to years. Segmental hair analysis can also document whether psychiatric patients are receiving a stable intake of antipsychotics. This study describes segmental analysis of the antipsychotic drug quetiapine in post-mortem hair samples from long-term quetiapine users by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analysis. The aim was to obtain more knowledge on quetiapine concentrations in hair and to relate the concentration in hair to the administered dose and the post-mortem concentration in femoral blood...
February 3, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29449054/second-generation-antipsychotic-induced-mitochondrial-alterations-implications-for-increased-risk-of-metabolic-syndrome-in-patients-with-schizophrenia
#3
Giselli Scaini, João Quevedo, Dawn Velligan, David L Roberts, Henriette Raventos, Consuelo Walss-Bass
Metabolic syndrome (MetS) is seen more frequently in persons with schizophrenia than in the general population, and these metabolic abnormalities are further aggravated by second generation antipsychotic (SGA) drugs. Although the underlying mechanisms responsible for the increased prevalence of MetS among patients under SGA treatment are not well understood, alterations in mitochondria function have been implicated. We performed a comprehensive evaluation of the role of mitochondrial dysfunction in the pathophysiology of drug-induced MetS in schizophrenia...
February 12, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29448305/development-and-validation-of-gc-ms-ms-method-for-simultaneous-quantitation-of-several-antipsychotics-in-human-plasma-and-oral-fluid
#4
Tiago Rosado, David Oppolzer, Belinda Cruz, Mário Barroso, Samira Varela, Victor Oliveira, Carlos Leitão, Eugenia Gallardo
RATIONALE: Antipsychotic drugs are prescription medications used to treat psychotic disorders, such as schizophrenia, schizoaffective disorder, or psychotic depression. With several antipsychotic drugs currently available all over the world, this class of drugs has quickly gotten importance in both clinical and forensic context. This work describes the development and validation of a methodology for the determination of seven antipsychotic drugs in plasma and oral fluid samples. METHODS: The antipsychotic drugs (chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, cyamemazine and, levomepromazine) were isolated from 0...
February 15, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29448172/analysis-of-quetiapine-in-human-plasma-using-fluorescence-spectroscopy
#5
Islam M Mostafa, Mahmoud A Omar, Dalia M Nagy, Sayed M Derayea
A simple and sensitive spectrofluorimetric method has been development for the assurance of quetiapine fumarate (QTF). The proposed method was utilized for measuring the fluorescence intensity of the yellow fluorescent product at 510nm (λ ex 470nm). The fluorescent product has resulted from the nucleophilic substitution reaction of QTF with 4-chloro-7-nitrobenzofurazane (NBD-Cl) in Mcllvaine buffer (pH7.0). The diverse variables influencing the development of the reaction product were deliberately changed and optimized...
February 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29446641/persistent-mania-following-cessation-of-corticosteroids
#6
M G Roxanas
OBJECTIVES: The aims of this study are to describe two patients whose manic symptoms persisted for several months after the cessation of corticosteroids, to review the literature and to suggest treatment. METHODS: The presentation of two elderly patients with persistent manic symptoms following cessation of corticosteroids several months previously afforded the author the opportunity to examine them carefully, investigate and treat them. RESULTS: The patients were investigated to rule out other causes and were treated with sodium valproate and quetiapine (in the second patient)...
February 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29441712/effectiveness-of-maintenance-therapy-of-lithium-vs-other-mood-stabilizers-in-monotherapy-and-in-combinations-a-systematic-review-of-evidence-from-observational-studies
#7
REVIEW
Lars Vedel Kessing, Michael Bauer, Willem A Nolen, Emanuel Severus, Guy M Goodwin, John Geddes
OBJECTIVES: For the first time to present a systematic review of observational studies on the efficiency of lithium monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination. METHODS: As part of the International Society for Bipolar Disorders (ISBD) Task Force on Lithium Treatment, we undertook a systematic literature search of non-randomized controlled observational studies on (i) lithium monotherapy vs treatment with another maintenance mood stabilizer in monotherapy and (ii) lithium in combination with other mood stabilizers vs monotherapy...
February 14, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29441189/neuroleptic-malignant-syndrome-a-case-responding-to-electroconvulsive-therapy-plus-bupropion
#8
Quintí Foguet-Boreu, Montse Coll-Negre, Montse Serra-Millàs, Miquel Cavalleria-Verdaguer
Neuroleptic malignant syndrome (NMS) is a severe motor syndrome occurring as a consequence of neuroleptic treatment. We present a case of a 67-year-old Caucasian woman with a history of a major depressive disorder with psychotic features. During her third hospital admission, symptoms of autonomic instability, hyperpyrexia, severe extrapyramidal side effects, and delirium appeared, suggesting NMS due to concomitant treatment with risperidone and quetiapine, among other drugs. Despite several consecutive pharmacological treatments (lorazepam, bromocriptine and amantadine) and prompt initiation of electroconvulsive therapy (ECT), clinical improvement was observed only after combining bupropion with ECT...
January 8, 2018: Clinics and Practice
https://www.readbyqxmd.com/read/29440213/does-industry-sponsored-education-foster-overdiagnosis-and-overtreatment-of-depression-osteoporosis-and-over-active-bladder-syndrome-an-australian-cohort-study
#9
Barbara Mintzes, Swestika Swandari, Alice Fabbri, Quinn Grundy, Ray Moynihan, Lisa Bero
OBJECTIVES: To investigate patterns of industry-sponsored educational events that focus on specific health conditions for which there are concerns about overdiagnosis and overtreatment. DESIGN AND SETTING: This retrospective cohort study examines publicly reported industry-sponsored events in Australia from October 2011 to September 2015 for three conditions potentially subject to overdiagnosis and overtreatment: depression, osteoporosis and overactive bladder. We used a database of transparency reports to identify events with a focus on depression, osteoporosis and overactive bladder and compared these with other sponsored events...
February 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29437023/serum-dhea-s-testosterone-and-cortisol-levels-in-female-patients-with-schizophrenia
#10
Suheyla Dogan Bulut, Serdar Bulut, Ayse G Gundogmus, Cigdem Aydemir
OBJECTIVE: Recent studies have shown that sex hormones play a role in the development of schizophrenia and the severity of disease symptoms. However, study results have been inconsistent. This study compares the relationship between the severity of disease symptoms and levels of testosterone, and DHEA-S and cortisol in premenopausal female patients with schizophrenia and a matched group of healthy controls. METHODS: The study sample included 32 women who were diagnosed as having schizophrenia according to DSM-IV TR criteria, and 32 age- and sex-matched healthy controls...
February 11, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29434130/a-case-of-quetiapine-related-acute-kidney-injury-requiring-transient-continuous-hemodiafiltration
#11
Haruhi Yamada, Yukiko Katsumori, Miki Kawano, Shumpei Mori, Ryo Takeshige, Jun Mukai, Hiroshi Imada, Hiroyuki Shimoura, Hachidai Takahashi, Tadasu Horai, Yutaka Okita, Ken-Ichi Hirata
A 73-year-old man, with congestive heart failure due to combined valvar disease, underwent curative surgery. Although the surgery was successful, his clinical course was eventful because of pulmonary complications, and he began to deteriorate mentally. Quetiapine was prescribed, which appeared to effectively settle his mental status. Following the administration of quetiapine, however, he developed acute kidney injury (AKI) that required continuous hemodiafiltration. Subsequent to discontinuation of quetiapine, his renal function gradually improved...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29432503/therapeutic-drug-monitoring-of-atypical-antipsychotics
#12
REVIEW
Anna Emilia Urban, Wiesław Jerzy Cubała
The paper presents an overview and analysis of the results of research on therapeutic ranges of concentrations and receptor occupancy, mainly D2 receptors, in the treatment with some atypical antipsychotic drugs. Amisulpride, aripiprazole, clozapine, quetiapine, olanzapine, risperidone, paliperidone, sertindole, and ziprasidone were taken into account. The benefits of therapeutic drug monitoring to optimize the effectiveness of treatment and avoid side effects or toxicity were shown. The safety of patients, with the possibility to use the lowest effective dose, is an undoubted profit of TDM...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29429138/qtc-prolongation-in-short-term-treatment-of-schizophrenia-patients-effects-of-different-antipsychotics-and-genetic-factors
#13
Ilja Spellmann, Matthias A Reinhard, Diana Veverka, Peter Zill, Michael Obermeier, Sandra Dehning, Rebecca Schennach, Norbert Müller, Hans-Jürgen Möller, Michael Riedel, Richard Musil
Antipsychotics are effective in treating schizophrenia but may lead to a higher cardiovascular risk due to QTc prolongation. Besides drugs, genetic and clinical factors may contribute to QTc prolongation. The aim of this study is to examine the effect of candidate genes known for QTc prolongation and their interaction with common antipsychotics. Thus, 199 patients were genotyped for nine polymorphisms in KCNQ1, KCNH2, SCN5A, LOC10537879, LOC101927066, NOS1AP and NUBPL. QTc interval duration was measured before treatment and weekly for 5 weeks while being treated with risperidone, quetiapine, olanzapine, amisulpride, aripiprazole and haloperidol in monotherapy...
February 10, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29422132/dried-blood-spots-and-parallel-artificial-liquid-membrane-extraction-a-simple-combination-of-microsampling-and-microextraction
#14
Kristine Skoglund Ask, Elisabeth Leere Øiestad, Stig Pedersen-Bjergaard, Astrid Gjelstad
In this paper, parallel artificial liquid membrane extraction (PALME) was used for the first time to clean-up dried blood spots (DBS) prior to ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Fundamental studies exploring amongst others desorption from the DBS in alkaline or acidic aqueous conditions, total extraction time and absolute recoveries were executed. Desorption and PALME were performed using a set of two 96-well plates, one of them housing the sample and the other comprising the supported liquid membrane (SLM) and the acceptor solution...
June 7, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29417979/facial-and-bilateral-leg-edema-in-a-patient-using-quetiapine
#15
Ebru Şahan, Meliha Zengin Eroğlu
No abstract text is available yet for this article.
January 2018: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29410934/insight-and-treatment-outcomes-in-schizophrenia-post-hoc-analysis-of-a-long-term-double-blind-study-comparing-lurasidone-and-quetiapine-xr
#16
Philip D Harvey, Cynthia O Siu, Antony D Loebel
Objective: The objective of this post-hoc analysis was to evaluate the effect of lurasidone and quetiapine extended-release (XR) on insight and judgment and assess the longitudinal relationships between improvement in insight and cognitive performance, functional capacity, quality of well-being, and depressive symptoms in patients with schizophrenia. Design: Clinically unstable patients with schizophrenia (N=488) were randomized to once-daily, fixed-dose treatment with lurasidone 80mg, lurasidone 160mg, quetiapine XR 600mg, or placebo, followed by a long-term, double-blind, flexible-dose continuation study involving these agents...
December 1, 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29409162/antipsychotic-reduction-and-or-cessation-and-antipsychotics-as-specific-treatments-for-tardive-dyskinesia
#17
REVIEW
Hanna Bergman, John Rathbone, Vivek Agarwal, Karla Soares-Weiser
BACKGROUND: Since the 1950s antipsychotic medication has been extensively used to treat people with chronic mental illnesses such as schizophrenia. These drugs, however, have also been associated with a wide range of adverse effects, including movement disorders such as tardive dyskinesia (TD) - a problem often seen as repetitive involuntary movements around the mouth and face. Various strategies have been examined to reduce a person's cumulative exposure to antipsychotics. These strategies include dose reduction, intermittent dosing strategies such as drug holidays, and antipsychotic cessation...
February 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29403139/quetiapine-induced-diabetic-ketoacidosis
#18
Soumitra Das, Dhanya S Palappallil, Arjun Kartha, Varun Rajan
Psychomotor retardation and extrapyramidal symptoms have limited the conventional antipsychotic use. Atypical antipsychotics though widely prescribed with good tolerability and efficacy, the metabolic complications associated with them are of clinical importance. Diabetic ketoacidosis (DKA) is a fatal complication of atypical antipsychotic use. We report a case of new-onset diabetes presenting as DKA with quetiapine use.
January 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29401113/clozapine-for-treatment-refractory-behavioral-disturbance-in-dementia
#19
Andreea Teodorescu, Lorena Dima, Petru Ifteni, Liliana M Rogozea
BACKGROUND: Behavioral and psychological symptoms in dementia significantly contribute to caregiver burden and impose patient hospitalization. The goal of treatment of admitted patients is the rapid remission of symptoms to allow their return to home as soon as possible. Intervention requires an intrusive approach with parenteral treatment and physical restraints, with a negative emotional impact on patients and their families. Despite the large utilization of antipsychotics for behavioral and psychological symptoms, there is no antipsychotic approved by the Food and Drug Administration for agitation in dementia...
January 31, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29392351/determination-of-plasma-concentration-reference-ranges-for-oral-aripiprazole-olanzapine-and-quetiapine
#20
Julia Korell, Bruce Green, Allan Rae, Bart Remmerie, An Vermeulen
BACKGROUND: Schizophrenia is a common disease which is commonly managed using antipsychotic medications (APS). Inadequate response and lack of adherence often prevent optimal therapeutic effectiveness. Monitoring APS concentrations can be useful to help improve outcomes for the patient. AIMS: The aim of this study was to develop "reference ranges" for oral aripiprazole, olanzapine, and quetiapine to allow clinicians to understand expected variability in patients treated with APS...
February 1, 2018: European Journal of Clinical Pharmacology
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