keyword
MENU ▼
Read by QxMD icon Read
search

Quetiapine

keyword
https://www.readbyqxmd.com/read/29690558/abuse-of-prescription-drugs-in-the-context-of-novel-psychoactive-substances-nps-a-systematic-review
#1
REVIEW
Fabrizio Schifano, Stefania Chiappini, John M Corkery, Amira Guirguis
Recently, a range of prescription and over-the-counter drugs have been reportedly used as Novel Psychoactive Substances (NPS), due to their potential for abuse resulting from their high dosage/idiosyncratic methods of self-administration. This paper provides a systematic review of the topic, focusing on a range of medications which have emerged as being used recreationally, either on their own or in combination with NPS. Among gabapentinoids, pregabalin may present with higher addictive liability levels than gabapentin, with pregabalin being mostly identified in the context of opioid, polydrug intake...
April 22, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29679069/pharmacological-treatment-of-adult-bipolar-disorder
#2
REVIEW
Ross J Baldessarini, Leonardo Tondo, Gustavo H Vázquez
We summarize evidence supporting contemporary pharmacological treatment of phases of BD, including: mania, depression, and long-term recurrences, emphasizing findings from randomized, controlled trials (RCTs). Effective treatment of acute or dysphoric mania is provided by modern antipsychotics, some anticonvulsants (divalproex and carbamazepine), and lithium salts. Treatment of BD-depression remains unsatisfactory but includes some modern antipsychotics (particularly lurasidone, olanzapine + fluoxetine, and quetiapine) and the anticonvulsant lamotrigine; value and safety of antidepressants remain controversial...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29670329/preparation-and-in-vitro-in-vivo-evaluation-of-plga-microspheres-containing-norquetiapine-for-long-acting-injection
#3
Chun-Woong Park, Hyo-Jung Lee, Dong-Won Oh, Ji-Hyun Kang, Chang-Soo Han, Dong-Wook Kim
Background: Norquetiapine ( N -desalkyl quetiapine, NQ) is an active metabolite of quetiapine with stable pharmacokinetic and pharmacological properties. However, its short half-life is a drawback for clinical applications, and long-acting formulations are required. Purpose: The objectives of this study were to prepare improved entrapment efficiency NQ freebase microspheres by the solvent evaporation method with poly(d,l-lactic-co-glycolic acid) (PLGA) as a release modulator and to evaluate their physicochemical and in vitro/in vivo release properties...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29649903/pharmacokinetic-evaluation-of-quetiapine-fumarate-controlled-release-hybrid-hydrogel-a-healthier-treatment-of-schizophrenia
#4
Muhammad Akhlaq, Faiza Maryam, Abdelhamid Elaissari, Hashmat Ullah, Muhammad Adeel, Abid Hussain, Muhammad Ramzan, Obaid Ullah, Muhammad Zeeshan Danish, Shehla Iftikhar, Nighat Aziz
The current study aimed to rationally develop and characterize pH-sensitive controlled release hydrogels by graft polymerization of gelatin (Gel) and hydroxypropyl methyl cellulose (HPMC) in the presence of glutaraldehyde (GA) using quetiapine fumarate for the treatment of schizophrenia. The prepared hydrogels discs were subjected to various physicochemical studies including: swelling, diffusion, porosity, sol-gel analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29644756/quetiapine-for-parkinson-s-disease-psychosis-evidence-based-medicine-versus-expert-belief-a-case-study
#5
Joseph H Friedman
No abstract text is available yet for this article.
April 11, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29642718/psychotropic-pharmacotherapy-associated-with-qt-prolongation-among-veterans-with-posttraumatic-stress-disorder
#6
Eileen M Stock, John E Zeber, Catherine J McNeal, Javier E Banchs, Laurel A Copeland
BACKGROUND: In 2012, the Food and Drug Administration issued Drug Safety Communications on several drugs associated with QT prolongation and fatal ventricular arrhythmias. Among these was citalopram, a selective serotonin reuptake inhibitor (SSRI) approved for depression and commonly used for posttraumatic stress disorder (PTSD). Evaluation of the risk for QT prolongation among other psychotropic drugs for individuals with PTSD remains limited. OBJECTIVE: Explore psychotropic drugs associated with QT prolongation among veterans with PTSD...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29627920/advances-in-pharmacotherapy-of-late-life-depression
#7
REVIEW
John L Beyer, Kim G Johnson
This paper reviews recent research on late-life depression (LLD) pharmacotherapy, focusing on updated information for monotherapy and augmentation treatments. We then review new research on moderators of clinical response and how to use the information for improved efficacy. RECENT FINDINGS: A recent review shows that sertraline, paroxetine, and duloxetine were superior to placebo for the treatment of LLD. There is concern that paroxetine could have adverse outcomes in the geriatric population due to anticholinergic properties; however, studies show no increases in mortality, dementia risk, or cognitive measures...
April 7, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29627379/the-antipsychotic-drug-quetiapine-stimulates-oligodendrocyte-differentiation-by-modulating-the-cell-cycle
#8
Guiyun Mi, Yituo Wang, Enmao Ye, Yunyun Gao, Qiaowei Liu, Pinhong Chen, Yuyang Zhu, Hongju Yang, Zheng Yang
Recent studies have revealed that oligodendrocyte differentiation deficits and de-myelination occur in the brains of schizophrenic patients. Cell cycle proteins play a critical role in modulating oligodendrocyte proliferation and differentiation. In our previous studies, we found that cuprizone, a copper chelant, induces oligodendrocyte loss and demyelination, and this effect can be alleviated by using the atypical antipsychotic drug quetiapine. To explore the mechanisms of quetiapine in oligodendrocyte development, we examined the effects of quetiapine on cell cycle progression...
April 5, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29626263/investigation-of-the-pharmaceutical-care-in-one-elderly-parkinson-s-disease-patient-with-psychotic-symptoms
#9
Chun-Ping Gu, Yue-Liang Xie, Yin-Juan Liao, Cui-Fang Wu, Sheng-Feng Wang, Yu-Lu Zhou, Su-Jie Jia
A 66-year-old male patient with a 10-year course of Parkinson's disease (PD) was admitted for hallucination lasting a half a month. After treatment with levodopa/carbidopa, selegiline, and piribedil, the patient's motor symptoms were improved while no significant effects were observed on psychotic symptoms. A clinical pharmacist analyzed the pharmacologic and pharmacokinetic characteristics of selegiline and piribedil, summarized the scheme of PD with psychotic symptoms in the literature, and discovered that selegiline might potentiate psychotic side effects of piribedil, while the use of levodopa/carbidopa cannot be ruled out either...
April 6, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29625538/hospitalization-risk-in-bipolar-disorder-patients-treated-with-lurasidone-versus-other-atypical-antipsychotics
#10
Daisy Ng-Mak, Rachel Halpern, Krithika Rajagopalan, Antony Loebel
OBJECTIVE: This observational study compared the risk of hospitalization for patients with bipolar disorder when treated with lurasidone versus other oral atypical antipsychotics. METHODS: This U.S. commercial claims analysis (April 4, 2010 through September 24, 2014) used the Optum Research Database to identify adult patients with bipolar disorder treated with oral atypical antipsychotics (N = 11,132). The first claim for an atypical antipsychotic defined the index date, with pre-index and post-index periods of 180 and 360 days, respectively...
April 6, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29618351/hospitalization-outcomes-in-patients-with-schizophrenia-after-switching-to-lurasidone-or-quetiapine-a-us-claims-database-analysis
#11
John W Newcomer, Daisy Ng-Mak, Krithika Rajagopalan, Antony Loebel
BACKGROUND: This study compared hospital admission rates among adult patients with schizophrenia who switched to antipsychotic monotherapy with lurasidone or quetiapine. METHODS: This retrospective cohort study used U.S.-based Truven Health MarketScan® Medicaid Multi-State Database (April 2010 through December 2012) and MarketScan® Commercial Claims and Encounters Database (April 2010 through October 2013). Continuous enrollment for 6-months before and after medication initiation was required...
April 4, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29611249/association-rules-method-and-big-data-evaluating-frequent-medication-combinations-associated-with-fractures-in-older-adults
#12
Prasad S Nishtala, Te-Yuan Chyou, Fabian Held, David G Le Couteur, Danijela Gnjidic
BACKGROUND: The association rules method is a novel methodology to ascertain patterns of medication use and combinations associated with adverse drug events. OBJECTIVES: The aim of this case-crossover study was to apply the association rules method to ascertain medication combinations contributing to the risk of fractures in older adults. METHODS: A nationwide representative sample of New Zealanders aged ≥65 years was sourced from the pharmaceutical collection...
April 2, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29593414/a-low-dose-of-risperidone-resolved-charles-bonnet-syndrome-after-an-unsuccessful-trial-of-quetiapine-a-case-report
#13
Sultan H Alamri
Charles Bonnet syndrome (CBS) is a diagnosis of exclusion. Typical affected patients have impaired visual acuity, vivid recurring visual hallucinations, and no cognitive impairment. Vision loss is most commonly due to macular degeneration, although many other causes exist. Here, we report a case of an 87-year-old woman with CBS and discuss the diagnosis and treatment.
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29592958/use-of-haloperidol-versus-atypical-antipsychotics-and-risk-of-in-hospital-death-in-patients-with-acute-myocardial-infarction-cohort-study
#14
Yoonyoung Park, Brian T Bateman, Dae Hyun Kim, Sonia Hernandez-Diaz, Elisabetta Patorno, Robert J Glynn, Helen Mogun, Krista F Huybrechts
OBJECTIVE: To compare the risk of in-hospital mortality associated with haloperidol compared with atypical antipsychotics in patients admitted to hospital with acute myocardial infarction. DESIGN: Cohort study using a healthcare database. SETTING: Nationwide sample of patient data from more than 700 hospitals across the United States. PARTICIPANTS: 6578 medical patients aged more than 18 years who initiated oral haloperidol or oral atypical antipsychotics (olanzapine, quetiapine, risperidone) during a hospital admission with a primary diagnosis of acute myocardial infarction between 2003 and 2014...
March 28, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29580414/natural-gum-type-biopolymers-as-potential-modified-nonpolar-drug-release-systems
#15
Constain H Salamanca, Cristhian J Yarce, Roger A Moreno, Vanessa Prieto, Juanita Recalde
In this work, the relationship between surface properties and drug release mechanism from binary composition tablets formed by quetiapine fumarate and biopolymer materials was studied. The biopolymers correspond to xanthan and tragacanth gums, which are projected as modified drug release systems. The surface studies were carried out by the sessile drop method, while the surface free energy (SFE) was determinate through Young-Dupree and OWRK semi-empirical models. On the other hand, the drug release studies were performed by in vitro dissolution tests, where the data were analyzed through kinetic models of zero order, first order, Higuchi, and Korsmeyer-Peppas...
June 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29579279/distribution-of-eight-qt-prolonging-drugs-and-their-main-metabolites-between-postmortem-cardiac-tissue-and-blood-reveals-potential-pitfalls-in-toxicological-interpretation
#16
Christian R Mikkelsen, Jakob R Jornil, Ljubica V Andersen, Jytte Banner, Jørgen B Hasselstrøm
Femoral blood concentrations are usually used in postmortem toxicology to assess possible toxic effects of drugs. This includes QT-prolongation and other cardiac dysrhythmia, which could have been the cause of death. However, blood concentration is only a surrogate for the active site concentration, and therefore cardiac tissue concentration may provide a more accurate toxicological interpretation. Thus, cardiac tissue and femoral and cardiac blood concentrations were examined for eight frequently used QT-prolonging drugs (QTD) and their metabolites in a mentally ill population...
March 20, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29575543/identifying-off-label-prescriptions-through-data-mining-in-danish-community-pharmacy-servers-an-exploratory-study-on-desmopressin-diclofenac-fucidin-mirtazapine-and-quetiapine
#17
Monika Andrulyte, Ole Jannik Bjerrum
The term off-label use describes the prescription and administration of medicines outside of the terms for which it officially has been approved, including age, dose and indication. Off-label data can be generated from the Danish National Prescription Registry (DNPR) through combinations with diagnoses, however the community pharmacy servers provide equal, local, albeit less data through a faster and less constrained collection process. The data collection for this exploratory study took place at five community pharmacies in Denmark...
March 25, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29570608/antioxidative-effect-of-quetiapine-on-acute-ultraviolet-b-induced-skin-and-hacat-cell-damage
#18
Pengcheng Xu, Min Zhang, Xueer Wang, Yuan Yan, Yinghua Chen, Wei Wu, Lu Zhang, Lin Zhang
Quetiapine is a new type of antipsychotic drug, with effective protection of pheochromocytoma PC12 cells from oxidative stress-induced apoptosis. Ultraviolet-B radiation can increase reactive oxygen species (ROS) production, resulting in significant inflammatory responses in damaged skin. Thus, the purpose of this study is to explore whether quetiapine protects the skin from intermediate-wave ultraviolet (UVB)-induced damage through antioxidant stress. In vivo, we found quetiapine treatment was able to significantly decrease skin thickness, erythema, and edema, as well as inflammation compared to control group...
March 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29569829/compartment-syndrome-of-the-deltoid-and-pectoralis-major-in-a-young-man-following-quetiapine-use
#19
Gayatri Seewoogoolam, George Miller, Beryl Tan
No abstract text is available yet for this article.
March 23, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29558759/vitamin-b12-in-association-with-antipsychotic-drugs-can-modulate-the-expression-of-pro-anti-inflammatory-cytokines-in-alzheimer-disease-patients
#20
Alireza Vakilian, Seyed Moein Razavi-Nasab, Ali Ravari, Tayebeh Mirzaei, Amir Moghadam-Ahmadi, Nazanin Jalali, Reza Bahramabadi, Mohammadtaghi Rezayati, Amin Yazdanpanah-Ravari, Farhad Bahmaniar, Mohammad Reza Bagheri, Mahmood Sheikh Fathollahi, Gholamreza Asadikaram, Mohammad Kazemi Arababadi
INTRODUCTION: Patients with Alzheimer disease (AD) suffer from psychotic symptoms including pain. The current antipsychotic drugs confer limited effectiveness, and hence new strategies are being designed to decrease pain in order to increase antipsychological effectiveness. Vitamin B12 is a safe supplementary drug to decrease pain. Additionally, cytokines participate in the pathogenesis of immune-related diseases such as AD. Thus, the main aim of this clinical trial study was to determine the effects of treatment with risperidone and quetiapine, as antipsychotic drugs, with and without vitamin B12 on the psychotic symptoms of AD patients and the expression of IL-6, IL-8, tumor growth factor (TGF)-β, tumor necrosis factor (TNF)-α, and endothelin (ET)-1)...
March 20, 2018: Neuroimmunomodulation
keyword
keyword
4836
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"