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Adipocyte and breast cancer

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https://www.readbyqxmd.com/read/29653286/stromal-cell-laden-3d-hydrogel-microwell-arrays-as-tumor-microenvironment-model-for-studying-stiffness-dependent-stromal-cell-cancer-interactions
#1
Xiaoshan Yue, Trung Dung Nguyen, Victoria Zellmer, Siyuan Zhang, Pinar Zorlutuna
Tumor properties such as growth and metastasis are dramatically dependent on the tumor microenvironment (TME). However, the diversity of the TME including the stiffness and the composition of the extracellular matrix (ECM), as well as the involvement of stromal cells, makes it extremely difficult to establish proper in vitro models for studying tumor growth and metastasis. In this research, we fabricated a stromal cell-laden microwell array system with tunable stiffness ranging from 200 Pa up to 3 kPa, which covers the stiffness range of normal and cancerous mammary tissues, to study the effect of ECM stiffness on stromal-cancer interaction...
April 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29652604/an-engineered-human-adipose-collagen-model-for-in-vitro-breast-cancer-cell-migration-studies
#2
Robert David Hume, Lorraine Berry, Stefanie Reichelt, Michael D'Angelo, Jenny Gomm, Ruth Elizabeth Cameron, Christine Watson
Adipocytes are one of the major stromal cell components of the human breast. These cells play a key role in the development of the gland and are implicated in breast tumorigenesis. Frequently, directional stromal collagen I fibres are found surrounding aggressive breast tumours. These fibres enhance breast cancer cell migration and are associated with poor patient prognosis. We sought to recapitulate these stromal components in vitro to provide a 3D model comprising human adipose tissue and anisotropic collagen fibres...
March 8, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29619877/the-estrogen-related-receptors-in-metabolism-and-cancer-newer-insights
#3
Harmit S Ranhotra
The eukaryotic nuclear receptors (NRs) super-family of transcriptional factors include the estrogen-related receptors (ERRs) that have diverse roles in control of cellular energy balance, general metabolism, growth and development, immunity etc. Mouse knock-out models of specific ERR isoforms (ERRα, ERRβ and ERRγ) exhibit defects in several phenotypic traits. Newer findings indicate important roles of ERRs in the regulation of brown adipocyte tissue mitochondrial oxidative functions as well as metabolic control in association with hypoxia-inducible factors during cellular hypoxic state...
April 5, 2018: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/29540614/obesity-promotes-resistance-to-anti-vegf-therapy-in-breast-cancer-by-up-regulating-il-6-and-potentially-fgf-2
#4
Joao Incio, Jennifer A Ligibel, Daniel T McManus, Priya Suboj, Keehoon Jung, Kosuke Kawaguchi, Matthias Pinter, Suboj Babykutty, Shan M Chin, Trupti D Vardam, Yuhui Huang, Nuh N Rahbari, Sylvie Roberge, Dannie Wang, Igor L Gomes-Santos, Stefan B Puchner, Christopher L Schlett, Udo Hoffmman, Marek Ancukiewicz, Sara M Tolaney, Ian E Krop, Dan G Duda, Yves Boucher, Dai Fukumura, Rakesh K Jain
Anti-vascular endothelial growth factor (VEGF) therapy has failed to improve survival in patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy include the up-regulation of alternative angiogenic and proinflammatory factors. Obesity is associated with hypoxic adipose tissues, including those in the breast, resulting in increased production of some of the aforementioned factors. Hence, we hypothesized that obesity could contribute to anti-VEGF therapy's lack of efficacy. We found that BC patients with obesity harbored increased systemic concentrations of interleukin-6 (IL-6) and/or fibroblast growth factor 2 (FGF-2), and their tumor vasculature was less sensitive to anti-VEGF treatment...
March 14, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29481479/a-3-dimensional-biomimetic-platform-to-interrogate-the-safety-of-autologous-fat-transfer-in-the-setting-of-breast-cancer
#5
Yoshiko Toyoda, Karel-Bart Celie, Jonathan T Xu, Justin S Buro, Julia Jin, Alexandra J Lin, Kristy A Brown, Jason A Spector
INTRODUCTION: Obesity is a known risk factor for the development and prognosis of breast cancer. Adipocytes have been identified as a source of exogenous lipids in other cancer types and may similarly provide energy to fuel malignant survival and growth in breast cancer. This relationship is of particular relevance to plastic surgery, because many reconstructions after oncologic mastectomy achieve optimal aesthetics and durability using adjunctive autologous fat transfer (AFT). Despite the increasing ubiquity and promise of AFT, many unanswered questions remain, including safety in the setting of breast cancer...
February 23, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29474925/microrna-221-may-be-involved-in-lipid-metabolism-in-mammary-epithelial-cells
#6
Meiqiang Chu, Yong Zhao, Shuai Yu, Yanan Hao, Pengfei Zhang, Yanni Feng, Hongfu Zhang, Dongxue Ma, Jing Liu, Ming Cheng, Lan Li, Wei Shen, Hongfang Cao, Qiang Li, Lingjiang Min
Milk lipids, important for infant growth and development, are produced and secreted by mammary gland under the regulation of steroid hormones, growth factors, and microRNAs (miRNAs). miR-221 has been identified in milk and adipocytes and it plays important roles in regulating normal mammary epithelial hierarchy and breast cancer stem cells; however, its roles in lipid metabolism in mammary epithelial cells (MECs), the cells of lipid synthesis and secretion, are as yet unknown. Through overexpression or inhibition of miR-221 expression, we found that it regulated lipid metabolism in MECs and was expressed differentially at various stages during murine mammary gland development...
February 20, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29437708/expression-of-adipocyte-macrophage-fatty-acid-binding-protein-in-tumor-associated-macrophages-promotes-breast-cancer-progression
#7
Jiaqing Hao, Fei Yan, Yuwen Zhang, Ashley Triplett, Ying Zhang, Debra A Schultz, Yanwen Sun, Jun Zeng, Kevin A T Silverstein, Qi Zheng, David A Bernlohr, Margot P Cleary, Nejat K Egilmez, Edward Sauter, Shujun Liu, Jill Suttles, Bing Li
Tumor associated macrophages (TAM) play a critical role in cancer development and progression. However, the heterogeneity of TAM presents a major challenge to identify clinically-relevant markers for pro-tumor TAM. Here, we report that expression of adipocyte/macrophage fatty acid binding protein (A-FABP) in TAM promotes breast cancer progression. While upregulation of A-FABP was inversely associated with breast cancer survival, deficiency of A-FABP significantly reduced mammary tumor growth and metastasis...
February 6, 2018: Cancer Research
https://www.readbyqxmd.com/read/29433827/adipocytokines-and-breast-cancer
#8
REVIEW
Jiajia Li, Xianghui Han
A substantial number of studies have revealed that a growing list of cancers might be influenced by obesity. In this regard, one of the most prominent and well-characterized cancers is breast cancer, the leading cause of cancer death among women. Obesity is associated with an increased risk for the occurrence and development of breast cancer particular in postmenopausal women. Moreover, the relationship between adiposity and breast cancer risk is complex, with associations that differ depending on when body size is assessed (eg, premenopausal vs postmenopausal obesity) and when breast cancer is diagnosed (ie, premenopausal vs postmenopausal disease)...
January 8, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29415482/long-chain-omega-3-polyunsaturated-fatty-acid-supplementation-protects-against-adriamycin-and-cyclophosphamide-chemotherapy-induced-bone-marrow-damage-in-female-rats
#9
Chia-Ming Fan, Yu-Wen Su, Peter R Howe, Cory J Xian
Although bone marrow and bone toxicities have been reported in breast cancer survivors, preventative strategies are yet to be developed. Clinical studies suggest consumption of long chain omega-3 polyunsaturated fatty acids (LCn3PUFA) can attenuate age-related bone loss, and recent animal studies also revealed benefits of LCn3PUFA in alleviating bone marrow and bone toxicities associated with methotrexate chemotherapy. Using a female rat model for one of the most commonly used anthracycline-containing breast cancer chemotherapy regimens (adriamycin + cyclophosphamide) (AC) chemotherapy, this study investigated potential effects of daily LCn3PUFA consumption in preserving bone marrow and bone microenvironment during chemotherapy...
February 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29413760/multifaceted-roles-of-interleukin-6-in-adipocyte-breast-cancer-cell-interaction
#10
REVIEW
Jones Gyamfi, Minseob Eom, Ja-Seung Koo, Junjeong Choi
Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged as active participants in breast cancer progression and response to treatment through autocrine and paracrine interaction with the malignant cells. Adipose tissue is abundant in the breast cancer microenvironment; interactions with cancer cells create cancer-associated adipocytes which produce a variety of adipokines that influence breast cancer initiation, metastasis, angiogenesis, and cachexia...
January 30, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29389973/adipocyte-breast-cancer-cell-crosstalk-in-obesity-interferes-with-the-anti-proliferative-efficacy-of-tamoxifen
#11
Lauriane Bougaret, Laetitia Delort, Hermine Billard, Camille Le Huede, Céline Boby, Anne De la Foye, Adrien Rossary, Ali Mojallal, Odile Damour, Céline Auxenfans, Marie Paule Vasson, Florence Caldefie-Chezet
BACKGROUND: Obesity is a well-known risk factor of breast cancer in post-menopausal women that also correlates with a diminished therapeutic response. The influence of adipocytes and their secretome, i.e. adipokines, on the efficacy of hormone therapy has yet to be elucidated. METHODS: We investigated, ex vivo, whether mature adipocytes, differentiated from adipose stem cells of normal-weight (MA20) or obese (MA30) women, and their secretions, were able to counteract the effects of tamoxifen (Tx) which is known to decrease neoplastic cell proliferation...
2018: PloS One
https://www.readbyqxmd.com/read/29357128/contribution-of-adipose-tissue-to-development-of-cancer
#12
Alyssa J Cozzo, Ashley M Fuller, Liza Makowski
Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell-intrinsic anomalies. Due to the ubiquitous nature of adipose tissue, many types of solid tumors grow in proximate or direct contact with adipocytes and adipose-associated stromal and vascular components, such as fibroblasts and other connective tissue cells, stem and progenitor cells, endothelial cells, innate and adaptive immune cells, and extracellular signaling and matrix components...
December 12, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/29339455/high-n-acetyltransferase-1-expression-is-associated-with-estrogen-receptor-expression-in-breast-tumors-but-is-not-under-direct-regulation-by-estradiol-5-%C3%AE-androstane-3-%C3%AE-17-%C3%AE-diol-or-dihydrotestosterone-in-breast-cancer-cells
#13
Xiaoyan Zhang, Samantha M Carlisle, Mark A Doll, Robert C G Martin, J Christopher States, Carolyn M Klinge, David W Hein
N-acetyltransferase 1 (NAT1) is an enzyme that metabolizes carcinogens, which suggests a potential role in breast carcinogenesis. High NAT1 expression in breast tumors is associated with estrogen receptor α (ER α +) and the luminal subtype. We report that NAT1 mRNA transcript, protein, and enzyme activity were higher in human breast tumors with high expression of ER α / ESR1 compared with normal breast tissue. There was a strong correlation between NATb promoter and NAT1 protein expression/enzyme activity...
April 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29312586/glucose-impairs-tamoxifen-responsiveness-modulating-connective-tissue-growth-factor-in-breast-cancer-cells
#14
Maria Rosaria Ambrosio, Vittoria D'Esposito, Valerio Costa, Domenico Liguoro, Francesca Collina, Monica Cantile, Nella Prevete, Carmela Passaro, Giusy Mosca, Michelino De Laurentiis, Maurizio Di Bonito, Gerardo Botti, Renato Franco, Francesco Beguinot, Alfredo Ciccodicola, Pietro Formisano
Type 2 diabetes and obesity are negative prognostic factors in patients with breast cancer (BC). We found that sensitivity to tamoxifen was reduced by 2-fold by 25 mM glucose (High Glucose; HG) compared to 5.5 mM glucose (Low Glucose; LG) in MCF7 BC cells. Shifting from HG to LG ameliorated MCF7 cell responsiveness to tamoxifen. RNA-Sequencing of MCF7 BC cells revealed that cell cycle-related genes were mainly affected by glucose. Connective Tissue Growth Factor (CTGF) was identified as a glucose-induced modulator of cell sensitivity to tamoxifen...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311669/adipocyte-activated-oxidative-and-er-stress-pathways-promote-tumor-survival-in-bone-via-upregulation-of-heme-oxygenase-1-and-survivin
#15
Mackenzie K Herroon, Erandi Rajagurubandara, Jonathan D Diedrich, Elisabeth I Heath, Izabela Podgorski
Metastatic tumor cells engage the local tumor microenvironment and activate specific pro-survival mechanisms to thrive and progress in the harsh bone marrow niche. Here we show that the major contributors to the survival of carcinoma cells that have colonized the bone marrow are the adipocyte-induced oxidative stress and ER stress pathways. We demonstrate that upon exposure to adipocyte-rich environments in vitro or in vivo, bone-trophic prostate and breast tumor cells upregulate the oxidative stress enzyme, HO-1...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29249690/jak-stat3-regulated-fatty-acid-%C3%AE-oxidation-is-critical-for-breast-cancer-stem-cell-self-renewal-and-chemoresistance
#16
Tianyi Wang, Johannes Francois Fahrmann, Heehyoung Lee, Yi-Jia Li, Satyendra C Tripathi, Chanyu Yue, Chunyan Zhang, Veronica Lifshitz, Jieun Song, Yuan Yuan, George Somlo, Rahul Jandial, David Ann, Samir Hanash, Richard Jove, Hua Yu
Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance. How lipid metabolism regulates CSCs and chemoresistance remains elusive. Here, we demonstrate that JAK/STAT3 regulates lipid metabolism, which promotes breast CSCs (BCSCs) and cancer chemoresistance. Inhibiting JAK/STAT3 blocks BCSC self-renewal and expression of diverse lipid metabolic genes, including carnitine palmitoyltransferase 1B (CPT1B), which encodes the critical enzyme for fatty acid β-oxidation (FAO). Moreover, mammary-adipocyte-derived leptin upregulates STAT3-induced CPT1B expression and FAO activity in BCSCs...
January 9, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29222346/adiposity-inflammation-and-breast-cancer-pathogenesis-in-asian-women
#17
Neil M Iyengar, I-Chun Chen, Xi K Zhou, Dilip D Giri, Domenick J Falcone, Lisle A Winston, Hanhan Wang, Samantha Williams, Yen-Shen Lu, Tsu-Hsin Hsueh, Ann-Lii Cheng, Clifford A Hudis, Ching-Hung Lin, Andrew J Dannenberg
Obesity is associated with white adipose tissue (WAT) inflammation in the breast, elevated levels of the estrogen biosynthetic enzyme, aromatase, and systemic changes that predispose to breast cancer development. We examined whether WAT inflammation and its associated systemic effects correlate with body fat levels in an Asian population where body mass index (BMI) is not an accurate assessment of obesity and cancer risk. We also investigated whether biologic differences could account for the greater proportion of premenopausal estrogen receptor (ER)-positive breast cancer in Asian versus Western countries...
December 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29197120/resveratrol-inhibits-obesity-associated-adipose-tissue-dysfunction-and-tumor-growth-in-a-mouse-model-of-postmenopausal-claudin-low-breast-cancer
#18
Emily L Rossi, Subreen A Khatib, Steven S Doerstling, Laura W Bowers, Melissa Pruski, Nikki A Ford, Randolph D Glickman, Mengmeng Niu, Peiying Yang, Zhengrong Cui, John DiGiovanni, Stephen D Hursting
Adipose tissue dysregulation, a hallmark of obesity, contributes to a chronic state of low-grade inflammation and is associated with increased risk and progression of several breast cancer subtypes, including claudin-low breast tumors. Unfortunately, mechanistic targets for breaking the links between obesity-associated adipose tissue dysfunction, inflammation, and claudin-low breast cancer growth have not been elucidated. Ovariectomized female C57BL/6 mice were randomized (n = 15/group) to receive a control diet, a diet-induced obesity (DIO) diet, or a DIO + resveratrol (0...
March 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29193620/morphometric-study-of-adipocytes-on-breast-cancer-by-means-of-photonic-microscopy-and-image-analysis
#19
Luis Eduardo Suárez-Nájera, José Jorge Chanona-Pérez, Alejandra Valdivia-Flores, Daniel Marrero-Rodríguez, Mauricio Salcedo-Vargas, David Israel García-Ruiz, Marco Antonio Castro-Reyes
Worldwide, breast cancer (BrCa) is currently the leading cause of deaths associated to malignant lesions in adult women. Given that some studies have mentioned that peritumoral adipocytes may contribute to breast carcinogenesis, present work sought to quantitative evaluate the morphometry of these cells in a group of adult women. Three thousand six hundred sixty four breast adipocytes, that came from biopsies of a group of adult females with different types of breast carcinomas (ductal, lobular, and mixed) and one with normal tissues, were evaluated through an image analysis (IA) process regarding six morphometric descriptors: area (A), perimeter (P), Feret diameter (FD ), aspect ratio (AR), roundness factor (RF), and fractal dimension of cellular contour (FDC )...
February 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29192217/decreased-mirna-expression-in-klinefelter-syndrome
#20
Laura Cimino, Michele Salemi, Rossella Cannarella, Rosita A Condorelli, Giorgio Giurato, Giovanna Marchese, Sandro La Vignera, Aldo E Calogero
The widelyvariable phenotypic spectrum and the different severity of symptoms in men with Klinefelter syndrome (KS) suggest a role for epigenetic mediators. Therefore, the aim of this study is to evaluate the possible involvement of miRNAs in the clinical manifestations of KS. To accomplish this, we performed a transcriptome analysis in peripheral blood mononuclear cells (PBMCs) of 10 non-mosaic KS patients, 10 aged-matched healthy men and 10 aged-matched healthy female controls with normal karyotype. After RNA extraction from PBMC and the preparation of RNA libraries, the samples were sequenced using next generation high-throughput sequencing technology...
November 30, 2017: Scientific Reports
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