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Adipocyte and breast cancer

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https://www.readbyqxmd.com/read/27909909/obesity-biomarkers-metabolism-and-risk-of-cancer-an-epidemiological-perspective
#1
Katharina Nimptsch, Tobias Pischon
Obesity is associated with metabolic alterations that may pose a biological link between body fatness and risk of cancer. Elucidating the role of obesity-related biomarkers in cancer development is essential for developing targeted strategies aiming at obesity-associated cancer prevention. Molecular epidemiological studies of the past decades have provided evidence that major hormonal pathways linking obesity and cancer risk include the insulin and insulin-like growth factor-1 (IGF-1) axis, sex-steroid hormones, adipokines and chronic low-grade inflammation...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27903155/obesity-and-cancer-mechanisms-tumor-microenvironment-and-inflammation
#2
Neil M Iyengar, Ayca Gucalp, Andrew J Dannenberg, Clifford A Hudis
Purpose There is growing evidence that inflammation is a central and reversible mechanism through which obesity promotes cancer risk and progression. Methods We review recent findings regarding obesity-associated alterations in the microenvironment and the local and systemic mechanisms through which these changes support tumor growth. Results Locally, hyperadiposity is associated with altered adipose tissue function, adipocyte death, and chronic low-grade inflammation. Most individuals who are obese harbor inflamed adipose tissue, which resembles chronically injured tissue, with immune cell infiltration and remodeling...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27895151/high-fat-diet-promotes-mammary-gland-myofibroblast-differentiation-through-mir-140-downregulation
#3
Benjamin Wolfson, Yongshu Zhang, Ramkishore Gernapudi, Nadire Duru, Yuan Yao, Pang-Kuo Lo, Qun Zhou
Human breast adipose tissue is a heterogonous cell population consisting of mature white adipocytes, multipotent mesenchymal stem cells, committed progenitor cells, fibroblasts, endothelial cells, and immune cells. Dependent on external stimulation, adipose derived stem cells differentiate along diverse lineages into adipocytes, chondrocytes, osteoblasts, fibroblasts, and myofibroblasts. It is currently not fully understood how high-fat diet reprograms adipose-derived stem cells into myofibroblasts. In our study, we use regular-diet and high-fat diet induced obesity mouse models to investigate the role of dietary fat on myofibroblast differentiation in the mammary stromal microenvironment...
November 28, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27886379/supernatants-of-adipocytes-from-obese-vs-normal-weight-women-and-breast-cancer-cells-in-vitro-impact-on-angiogenesis
#4
L Bougaret, L Delort, H Billard, C Lequeux, N Goncalves-Mendes, A Mojallal, O Damour, M-P Vasson, F Caldefie-Chezet
Breast cancer is correlated with a higher risk of metastasis in obese postmenopausal women. Adipokines, whose plasma concentrations are modulated in obese subjects, surrounds mammary cells, suggesting that adipocyte secretions affect mammary tumorogenesis. We hypothsesis that matures adipocytes secretions from obese women conditioned or not by breast neoplasic cells, increase changes on the stages of angiogenesis. Supernatants of human matures adipocytes differentiated from stem cells of either adipose tissue of normal weight (MA20) or obese (MA30) women or obtained from co-cultures between MA20 or MA30 and breast cancer cell line MCF-7 were collected...
November 25, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27877077/amelioration-of-estrogen-deficiency-induced-obesity-by-collagen-hydrolysate
#5
Tsay-I Chiang, I-Chang Chang, Hsueh-Hui Lee, Kuang Hui Hsieh, Yung-Wei Chiu, Te-Jen Lai, Jer-Yuh Liu, Li-Sung Hsu, Shao-Hsuan Kao
Objectives: Menopausal transition with declining estrogen levels significantly affects the physiological properties of women and consequently contributes to a series of medical conditions, including obesity. Obesity is a crucial risk factor associated with cardiovascular diseases, diabetes mellitus, and breast cancer. Increasing dietary protein content improves satiety and energy expenditure. Thus, we hypothesize that supplementing with collagen, a common dietary protein, may alleviate menopause-induced obesity...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27876260/editorial-overview-endocrine-and-metabolic-diseases-adipocyte-dysfunction-fuels-signalings-for-breast-cancer-progression
#6
EDITORIAL
Sebastiano Andò
No abstract text is available yet for this article.
November 18, 2016: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/27875786/inflammation-dysregulated-metabolism-and-aromatase-in-obesity-and-breast-cancer
#7
REVIEW
Heba Zahid, Evan R Simpson, Kristy A Brown
Obesity is associated with an increased risk of estrogen-dependent breast cancer after menopause. Adipose tissue undergoes important changes in obesity due to excess storage of lipids, leading to adipocyte cell death and the recruitment of macrophages. The resultant state of chronic low-grade inflammation is associated with the activation of NFkB signaling and elevated levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis. This occurs not only in the visceral and subcutaneous fat, but also in the breast fat...
November 19, 2016: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/27851969/epigenomic-deconvolution-of-breast-tumors-reveals-metabolic-coupling-between-constituent-cell-types
#8
Vitor Onuchic, Ryan J Hartmaier, David N Boone, Michael L Samuels, Ronak Y Patel, Wendy M White, Vesna D Garovic, Steffi Oesterreich, Matt E Roth, Adrian V Lee, Aleksandar Milosavljevic
Cancer progression depends on both cell-intrinsic processes and interactions between different cell types. However, large-scale assessment of cell type composition and molecular profiles of individual cell types within tumors remains challenging. To address this, we developed epigenomic deconvolution (EDec), an in silico method that infers cell type composition of complex tissues as well as DNA methylation and gene transcription profiles of constituent cell types. By applying EDec to The Cancer Genome Atlas (TCGA) breast tumors, we detect changes in immune cell infiltration related to patient prognosis, and a striking change in stromal fibroblast-to-adipocyte ratio across breast cancer subtypes...
November 15, 2016: Cell Reports
https://www.readbyqxmd.com/read/27769315/leptin-promotes-epithelial-mesenchymal-transition-of-breast-cancer-via-the-upregulation-of-pyruvate-kinase-m2
#9
Lan Wei, Kuangfa Li, Xueli Pang, Bianqin Guo, Min Su, Yunxiu Huang, Nian Wang, Feihu Ji, Changli Zhong, Junhong Yang, Zhiqian Zhang, Yulin Jiang, Yifeng Liu, Tingmei Chen
BACKGROUND: Accumulating researches have shown that epithelial-mesenchymal transition (EMT) contributes to tumor metastasis. Leptin, a key adipokine secreted from adipocytes, shapes the tumor microenvironment, potentiates the migration of breast cancer cells and angiogenesis, and is also involved in EMT. However, the potential mechanism remains unknown. This study aims to explore the effect of leptin on EMT in breast cancer cells and the underlying mechanism. METHODS: With the assessment of EMT-associated marker expression in MCF-7, SK-BR-3, and MDA-MB-468 cells, the effect of leptin on breast cancer cells was analyzed...
October 21, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27765922/g-protein-coupled-receptor-81-promotes-a-malignant-phenotype-in-breast-cancer-through-angiogenic-factor-secretion
#10
Yu Jin Lee, Kyeong Jin Shin, Soo-Ah Park, Kyeong Su Park, Seorim Park, Kyun Heo, Young-Kyo Seo, Dong-Young Noh, Sung Ho Ryu, Pann-Ghill Suh
G-protein-coupled receptor 81 (GPR81) functions as a receptor for lactate and plays an important role in the regulation of anti-lipolytic effects in adipocytes. However, to data, a role for GPR81 in the tumor microenvironment has not been clearly defined. Here, GPR81 expression in breast cancer patients and several breast cancer cell lines was significantly increased compared with normal mammary tissues and cells. GPR81 knockdown resulted in impaired breast cancer growth and led to apoptosis both in vitro and in vivo...
September 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27708283/obesity-associated-nlrc4-inflammasome-activation-drives-breast-cancer-progression
#11
Ryan Kolb, Liem Phan, Nicholas Borcherding, Yinghong Liu, Fang Yuan, Ann M Janowski, Qing Xie, Kathleen R Markan, Wei Li, Matthew J Potthoff, Enrique Fuentes-Mattei, Lesley G Ellies, C Michael Knudson, Mong-Hong Lee, Sai-Ching J Yeung, Suzanne L Cassel, Fayyaz S Sutterwala, Weizhou Zhang
Obesity is associated with an increased risk of developing breast cancer and is also associated with worse clinical prognosis. The mechanistic link between obesity and breast cancer progression remains unclear, and there has been no development of specific treatments to improve the outcome of obese cancer patients. Here we show that obesity-associated NLRC4 inflammasome activation/ interleukin (IL)-1 signalling promotes breast cancer progression. The tumour microenvironment in the context of obesity induces an increase in tumour-infiltrating myeloid cells with an activated NLRC4 inflammasome that in turn activates IL-1β, which drives disease progression through adipocyte-mediated vascular endothelial growth factor A (VEGFA) expression and angiogenesis...
October 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27698011/accumulation-of-cd11c-cd163-adipose-tissue-macrophages-through-upregulation-of-intracellular-11%C3%AE-hsd1-in-human-obesity
#12
Shotaro Nakajima, Vivien Koh, Ley-Fang Kua, Jimmy So, Lomanto Davide, Kee Siang Lim, Sven Hans Petersen, Wei-Peng Yong, Asim Shabbir, Koji Kono
Adipose tissue (AT) macrophages (ATMs) are key players for regulation of AT homeostasis and obesity-related metabolic disorders. However, the phenotypes of human ATMs and regulatory mechanisms of their polarization have not been clearly described. In this study, we investigated human ATMs in both abdominal visceral AT and s.c. AT and proposed an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)-glucocorticoid receptor regulatory axis that might dictate M1/M2 polarization in ATMs. The accumulation of CD11c(+)CD163(+) ATMs in both visceral AT and s...
October 3, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27672333/eribulin-in-the-management-of-inoperable-soft-tissue-sarcoma-patient-selection-and-survival
#13
REVIEW
Colin Thomas, Sujana Movva
Patients diagnosed with metastatic soft-tissue sarcoma (STS) have a poor prognosis. Additionally, after failure of first-line therapy, there are relatively few treatment options from which to choose. The novel tubulin-binding drug, eribulin, with a unique mechanism of action from taxanes or vinca alkaloids, has shown clinical activity in several different types of cancers. Eribulin has been approved by the US Food and Drug Administration (FDA) for patients with metastatic breast cancer previously treated with an anthracycline or a taxane and has recently been FDA approved for patients with unresectable or metastatic liposarcoma who have failed a previous anthracycline regimen...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27651367/mycophenolic-acid-potentiates-her2-overexpressing-skbr3-breast-cancer-cell-line-to-induce-apoptosis-involvement-of-akt-foxo1-and-jak2-stat3-pathways
#14
Safiyeh Aghazadeh, Razieh Yazdanparast
Trastuzumab has been successfully used as a first-line therapy specific for HER2-overexressing breast cancer patients. However, despite the effectiveness of trastuzumab, the occurrence of inherent and acquired resistance remains as the main challenge of the therapy. Thus, this has motivated efforts toward finding new therapeutic strategies including combining trastuzumab with other drugs to enhance its therapeutic efficacy. In that line, we investigated the capability of mycophenolic acid (MPA), an inhibitor of de novo guanine nucleotide synthesis with potential anti-cancer activity, on improving the response to trastuzumab among SKBR3 cells as well as trastuzumab resistant SKBR3-TR cells...
November 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27572852/identification-of-hub-genes-and-regulatory-factors-of-glioblastoma-multiforme-subgroups-by-rna-seq-data-analysis
#15
Yanan Li, Weijie Min, Mengmeng Li, Guosheng Han, Dongwei Dai, Lei Zhang, Xin Chen, Xinglai Wang, Yuhui Zhang, Zhijian Yue, Jianmin Liu
Glioblastoma multiforme (GBM) is the most common malignant brain tumor. This study aimed to identify the hub genes and regulatory factors of GBM subgroups by RNA sequencing (RNA-seq) data analysis, in order to explore the possible mechanisms responsbile for the progression of GBM. The dataset RNASeqV2 was downloaded by TCGA-Assembler, containing 169 GBM and 5 normal samples. Gene expression was calculated by the reads per kilobase per million reads measurement, and nor malized with tag count comparison...
October 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27568102/invasive-breast-cancer-preferably-and-predominantly-occurs-at-the-interface-between-fibroglandular-and-adipose-tissue
#16
Wenlian Zhu, Susan Harvey, Katarzyna J Macura, David M Euhus, Dmitri Artemov
BACKGROUND: Increasing evidence suggests adipocyte involvement in malignant breast tumor invasive front or margin. The aim of this study was to evaluate the location of invasive breast tumors in relation to fibroglandular and adipose tissue by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). PATIENTS AND METHODS: Pretreatment breast DCE-MRI images of 294 patients with biopsy-proven invasive breast cancer from 2008 to 2014 were studied. Invasive breast tumors were visualized as enhanced lesions in the postcontrast subtraction images...
July 28, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27471491/bone-marrow-adipose-tissue-a-new-player-in-cancer-metastasis-to-bone
#17
REVIEW
Emma V Morris, Claire M Edwards
The bone marrow is a favored site for a number of cancers, including the hematological malignancy multiple myeloma, and metastasis of breast and prostate cancer. This specialized microenvironment is highly supportive, not only for tumor growth and survival but also for the development of an associated destructive cancer-induced bone disease. The interactions between tumor cells, osteoclasts and osteoblasts are well documented. By contrast, despite occupying a significant proportion of the bone marrow, the importance of bone marrow adipose tissue is only just emerging...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27448965/insulin-like-growth-factor-binding-protein-3-links-obesity-and-breast-cancer-progression
#18
Tiffany Scully, Sue M Firth, Carolyn D Scott, Hasanthi C de Silva, John E Pintar, Tailoi Chan-Ling, Stephen M Twigg, Robert C Baxter
Obesity is associated epidemiologically with poor breast cancer prognosis, but the mechanisms remain unclear. Since IGF binding protein-3 (IGFBP-3) influences both breast cancer growth and adipocyte maturation, it may impact on how obesity promotes breast oncogenesis. This study investigated the role of endogenous IGFBP-3 on the development of obesity and subsequently on breast tumor growth. Wild-type (WT) C57BL/6 or IGFBP-3-null (BP3KO) mice were fed a high-fat diet (HFD) or control chow-diet for 15 weeks before orthotopic injection with syngeneic EO771 murine breast cancer cells...
July 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27337108/one-step-detection-of-major-lipid-components-in-submicroliter-volumes-of-unpurified-liposome-and-cell-suspensions
#19
Ssu-Ying Chen, Ching-Yi Wu, Yu-Chie Chen, Pawel L Urban
Liposomes and cells have high lipid contents, which are the main components of the external and internal membranes. Mass spectrometry (MS) is widely used in the analysis of the lipids present in the biological matrixes. However, MS analysis of liposome and cell suspensions is challenging due to the presence of other high-abundance matrix components (e.g., salts, buffers, and growth media) that cause ion suppression. These interfering species would normally be removed by dialysis or centrifugation. Here we propose a simple and fast method to detect major lipid components in cells and cell suspensions by MS while circumventing dialysis and centrifugation...
July 19, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27283835/breast-cancers-from-black-women-exhibit-higher-numbers-of-immunosuppressive-macrophages-with-proliferative-activity-and-of-crown-like-structures-associated-with-lower-survival-compared-to-non-black-latinas-and-caucasians
#20
Tulay Koru-Sengul, Ana M Santander, Feng Miao, Lidia G Sanchez, Merce Jorda, Stefan Glück, Tan A Ince, Mehrad Nadji, Zhibin Chen, Manuel L Penichet, Margot P Cleary, Marta Torroella-Kouri
Racial disparities in breast cancer incidence and outcome are a major health care challenge. Patients in the black race group more likely present with an early onset and more aggressive disease. The occurrence of high numbers of macrophages is associated with tumor progression and poor prognosis in solid malignancies. Macrophages are observed in adipose tissues surrounding dead adipocytes in "crown-like structures" (CLS). Here we investigated whether the numbers of CD163+ tumor-associated macrophages (TAMs) and/or CD163+ CLS are associated with patient survival and whether there are significant differences across blacks, non-black Latinas, and Caucasians...
July 2016: Breast Cancer Research and Treatment
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