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Fibrosis and hernia

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https://www.readbyqxmd.com/read/27428024/hyperpolarized-gas-magnetic-resonance-lung-imaging-in-children-and-young-adults
#1
Lucia Flors, John P Mugler, Eduard E de Lange, Grady W Miller, Jaime F Mata, Nick Tustison, Iulian C Ruset, F William Hersman, Talissa A Altes
The assessment of early pulmonary disease and its severity can be difficult in young children, as procedures such as spirometry cannot be performed on them. Computed tomography provides detailed structural images of the pulmonary parenchyma, but its major drawback is that the patient is exposed to ionizing radiation. In this context, magnetic resonance imaging (MRI) is a promising technique for the evaluation of pediatric lung disease, especially when serial imaging is needed. Traditionally, MRI played a small role in evaluating the pulmonary parenchyma...
September 2016: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/27381600/development-of-critical-size-abdominal-defects-in-a-rabbit-model-to-mimic-mature-ventral-hernias
#2
Georgios Hilas, Michael Scott Taylor, Joel Corbett
BACKGROUND/AIM: Mesh hernioplasty is one of the most frequently performed procedures in the United States. Abdominal rigidity and chronic inflammation, among other factors, contribute to long-term complications including chronic pain, abdominal wall stiffness and fibrosis. Acute models do not replicate the chronic environment associated with most hernias, limiting the ability to improve products. The present study details development of a critical-size defect in rabbit abdominal wall for maturation into a chronic hernia to enable analysis of hernia repair devices in a realistic environment...
July 2016: In Vivo
https://www.readbyqxmd.com/read/27372030/omental-patch-reinforced-with-polypropylene-mesh-and-split-thickness-skin-grafting-a-new-procedure-to-close-the-open-abdomen
#3
Emilio Muñoz Muñoz, Fernando Pardo-Aranda, Esteban García-Olivares, Sandra Patricia Pontes De Sousa, Pilar Forcada, Enrique Veloso
INTRODUCTION: The "open abdomen" expression widely used to define a full-thickness defect of the abdominal wall intentionally made in some situations like abdominal compartment syndrome, has been replaced by a newest one called "laparostomy". The definitive closure of an open abdomen with a giant full abdominal thickness defect remains a problem. CASE REPORT: We present a 67-year old male with a descompressive laparostomy treated with a greater omentum flap sutured hermetically with interrupted stitches at the edges of the muscle wall, reinforced with large mesh of polypropylene (PP) placed on-lay and sutured to the fascia by two concentric running sutures of polypropylene...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27369286/evaluation-of-a-fully-absorbable-poly-4-hydroxybutyrate-absorbable-barrier-composite-mesh-in-a-porcine-model-of-ventral-hernia-repair
#4
Jeffrey R Scott, Corey R Deeken, Robert G Martindale, Michael J Rosen
BACKGROUND: The objective of this study was to evaluate the mechanical and histological properties of a fully absorbable poly-4-hydroxybutyrate/absorbable barrier composite mesh (Phasix™ ST) compared to partially absorbable (Ventralight™ ST), fully absorbable (Phasix™), and biologically derived (Strattice™) meshes in a porcine model of ventral hernia repair. METHODS: Bilateral abdominal surgical defects were created in twenty-four Yucatan pigs, repaired with intraperitoneal (Phasix™ ST, Ventralight™ ST) or retromuscular (Phasix™, Strattice™) mesh, and evaluated at 12 and 24 weeks (n = 6 mesh/group/time point)...
September 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27186066/hiatal-hernia-repair-with-novel-biological-graft-reinforcement
#5
Kent C Sasse, David L Warner, Ellen Ackerman, Jared Brandt
BACKGROUND AND OBJECTIVES: Hiatal hernias are repaired laparoscopically with increasing use of reinforcement material. Both synthetic and biologically derived materials reduce the recurrence rate compared to primary crural repair. Synthetic mesh introduces complications, such as mesh erosion, fibrosis, and infection. Urinary bladder matrix (UBM) represents a biologically derived material for use in hiatal hernia repair reinforcement with the potential to improve durability of repair without incurring the risks of other reinforcement materials...
April 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/27174889/hiatal-hernia-on-thoracic-computed-tomography-in-pulmonary-fibrosis
#6
Céline Tossier, Clairelyne Dupin, Laurent Plantier, Julie Leger, Thomas Flament, Olivier Favelle, Thierry Lecomte, Patrice Diot, Sylvain Marchand-Adam
Gastro-oesophageal reflux has long been suspected of implication in the genesis and progression of idiopathic pulmonary fibrosis (IPF). We hypothesised that hiatal hernia may be more frequent in IPF than in other interstitial lung disease (ILD), and that hiatal hernia may be associated with more severe clinical characteristics in IPF.We retrospectively compared the prevalence of hiatal hernia on computed tomographic (CT) scans in 79 patients with IPF and 103 patients with other ILD (17 scleroderma, 54 other connective tissue diseases and 32 chronic hypersensitivity pneumonitis)...
September 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27158482/endoscopic-and-histological-evaluations-of-a-newly-designed-inguinal-hernia-mesh-implant-experimental-studies-on-porcine-animal-model-and-human-cadaver
#7
Fabrizio Panaro, Ana Maria Matos-Azevedo, José Antonio Fatas, Juan Marin, Francis Navarro, Cristobal Zaragoza-Fernandez
PURPOSE: Conventional prostheses used for inguinal hernia repair are static and passive. This feasibility-study shows the features of a new 3D tension-free prosthesis in an experimental model. METHODS: This study was divided into two-phases: 1) aimed to test the physics intrinsic features and the anatomical adaptability of a new 3D designed mesh, and 2) aimed to evaluate the inflammatory reaction associated with different materials used. On phase-1 implantations were performed in pigs...
June 2015: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27146503/the-role-of-transforming-growth-factor-beta-1-in-communicating-and-non-communicating-hydrocele
#8
S A Mousavi, L V Larijani, S J Mousavi, S A Kenari, A Darvish
PURPOSE: Repair of inguinal hernia and hydrocele are one of the most common operations performed by surgeons. However, the exact biological mechanism responsible for the closure of processus vaginalis (PV) is not completely understood. Transforming growth factor beta 1 (TGF-β1) is a potent fibrogenic agent and probably stimulate fibrosis and disappearing of PV. METHODS: From September 2012 to December 2014, all boys from 1 to 5 years who were referred for surgery of hydrocele were divided into two groups of communicating (HC) or non-communicating hydrocele (HNC)...
August 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/27126254/biocompatibility-versus-peritoneal-mesothelial-cells-of-polypropylene-prostheses-for-hernia-repair-coated-with-a-thin-silica-silver-layer
#9
Giuliana Muzio, Sergio Perero, Marta Miola, Manuela Oraldi, Sara Ferraris, Enrica Vernè, Federico Festa, Rosa Angela Canuto, Valentino Festa, Monica Ferraris
Hernias are generally repaired using synthetic prostheses. Infection may already be present or develop during implantation. Based on the increasing resistance to antibiotics, and the well-known antimicrobial properties of silver (Ag), the possibility of coating hernia prostheses with a nanostructured layer containing Ag was explored. Prostheses (Clear Mesh Composite [CMC]) made up of two polypropylene layers (macroporous light mesh and thin transparent film) were tested with human mesothelial cells from omentum biopsies...
April 29, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27014698/functional-results-after-repair-of-large-hiatal-hernia-by-use-of-a-biologic-mesh
#10
Filimon Antonakis, Ferdinand Köckerling, Friedrich Kallinowski
BACKGROUND: The aim of this observational study is to analyze the results of patients with large hiatal hernia and upside-down stomach after surgical closure with a biological mesh (Permacol(®), Covidien, Neustadt an der Donau, Germany). Biological mesh is used to prevent long-term detrimental effects of artificial meshes and to reduce recurrence rates. METHODS: A total of 13 patients with a large hiatal hernia and endothoracic stomach, who underwent surgery between 2010 and 2014, were included...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27000660/hydrogel-coated-mesh-decreases-tissue-reaction-resulting-from-polypropylene-mesh-implant-implication-in-hernia-repair
#11
D P Poppas, J J Sung, C M Magro, J Chen, J P Toyohara, B J Ramshaw, D Felsen
PURPOSE: Use of polypropylene mesh (PPM) in hernia repair is associated with tissue reactivity. We examined, in a rat model, a novel non-biodegradable hydrogel coated PPM which may allow for decreased inflammation and a decreased foreign body reaction. METHODS: Through a dorsal midline incision, a 2 cm × 2 cm section of PPM (either coated or uncoated) was placed on the fascial surface 1.5 cm from the incision on the dorsal wall of Sprague-Dawley rats. At 2 and 12 weeks after placement, the PPM and surrounding tissue were harvested...
August 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/26980038/could-prominent-airway-centered-fibroblast-foci-in-lung-biopsies-predict-underlying-chronic-microaspiration-in-idiopathic-pulmonary-fibrosis-patients
#12
Melanie C Bois, Xiaowen Hu, Jay H Ryu, Eunhee S Yi
Chronic occult aspiration of small droplets (microaspiration) due to gastroesophageal reflux disease (GERD) and/or hiatal hernia is postulated to be a contributing factor in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Usual interstitial pneumonia (UIP) is the histopathologic correlate of IPF. We hypothesized that chronic microaspiration may manifest as prominent airway-centered fibroblastic foci (FFs) in IPF. UIP cases diagnosed by wedge biopsies over a 6-year period (2006-2011) were identified and scored (1-3) for the prominence of airway-centered FFs by 2 authors blinded for clinical history...
July 2016: Human Pathology
https://www.readbyqxmd.com/read/26907997/spontaneous-regression-of-herniated-lumbar-discs-report-of-one-illustrative-case-and-review-of-the-literature
#13
REVIEW
Xiaohui Yang, Qin Zhang, Xiaoning Hao, Xinghua Guo, Liping Wang
Lumbar disc herniation (LDH) is a common disease that induces back pain and radicular pain. The most efficient method for the treatment of lumbar disc herniation is still controversial. Spontaneous regression of LDH has been recognized with the advancement of radiological diagnostic tools and can explain the reason of spontaneous relief of symptoms without treatment. The proposed hypotheses are; dehydration, retraction of the disc to the hernia in the annulus fibrosis, enzymatic catabolism and phagocytosis...
April 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/26650726/chronic-pain-after-tep-inguinal-hernia-repair-does-mri-reveal-a-cause
#14
J P J Burgmans, C E H Voorbrood, T Van Dalen, R N Boxhoorn, G J Clevers, F B M Sanders, D B J Naafs, R K J Simmermacher
PURPOSE: Persistent pain is a known side effect after TEP inguinal repair disabling 2-5% of patients. A standardized diagnostic work-up so far is not available. MRI is a diagnostic tool in the work-up of inguinal hernias. In the present study the yield of MRI in evaluating chronic pain after TEP hernia repair is addressed. METHODS: In our database patients receiving an MRI scan for groin pain lasting more than 3 months after TEP inguinal hernia repair were identified...
February 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/26645213/screening-for-helicobacter-pylori-in-idiopathic-pulmonary-fibrosis-lung-biopsies
#15
Michael Kreuter, Detlef Kirsten, Thomas Bahmer, Roland Penzel, Martin Claussen, Svenja Ehlers-Tenenbaum, Thomas Muley, Karin Palmowski, Monika Eichinger, Marta Leider, Felix J F Herth, Klaus F Rabe, Iris Bittmann, Arne Warth
BACKGROUND: Increasing evidence suggests a role of gastro-oesophageal reflux (GER) in idiopathic pulmonary fibrosis (IPF) pathogenesis. Recently, an association between serum Helicobacter pylori (HP) antibody positivity and more severe disease was described, but HP has not been directly analysed in lung tissue so far. OBJECTIVE: To investigate the presence of HP in the lung tissue of IPF patients. METHODS: Two tertiary interstitial lung disease care centre databases were screened for available lung biopsy material from IPF patients...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/26594357/a-randomized-controlled-experimental-study-comparing-chitosan-coated-polypropylene-mesh-and-proceed%C3%A2-mesh-for-abdominal-wall-defect-closure
#16
S T Jayanth, Anna Pulimood, Deepak Abraham, A Rajaram, M J Paul, Aravindan Nair
BACKGROUND: Abdominal wall defects and hernias are commonly repaired with synthetic or biological materials. Adhesions and recurrences are a common problem. A study was conducted to compare Chitosan coated polypropylene mesh and a polypropylene-polydioxanone composite with oxidized cellulose coating mesh (Proceed™) in repair of abdominal wall defect in a Rabbit hernia model. METHODS: A randomized controlled experimental study was done on twelve New Zealand white rabbits...
December 2015: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/26537143/copaiba-oil-influences-ventral-hernia-repair-with-vicryl%C3%A2-mesh
#17
Edson Yuzur Yasojima, Renan Kleber Costa Teixeira, Abdallah de Paula Houat, Felipe Lobato da Silva Costa, Vitor Nagai Yamaki, Denilson José Silva Feitosa-Junior, Carlos Augusto Moreira Silva, Marcus Vinicius Henriques Brito
BACKGROUND: The use of meshes in hernia surgical repair promoted revolution in the surgical area; however, some difficulties had come, such as a large area of fibrosis, greater postoperative pain and risk of infection. The search for new substances that minimize these effects should be encouraged. Medicinal plants stand out due possible active ingredients that can act on these problems. AIM: To check the copaiba oil influence in the repair of abdominal defects in rats corrected with Vicryl(c) mesh...
July 2015: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/26476053/successful-treatment-for-patients-with-chronic-orchialgia-following-inguinal-hernia-repair-by-means-of-meshoma-removal-orchiectomy-and-triple-neurectomy
#18
Masato Narita, Koki Moriyoshi, Keita Hanada, Ryo Matsusue, Hiroaki Hata, Takashi Yamaguchi, Tetsushi Otani, Iwao Ikai
INTRODUCTION: Orchialgia following inguinal hernia repair is rare complication and still challenging since there has been no established surgical treatment because of complexity of nerve innervation to the testicular area. Herein we report a case of postoperative orchialgia following Lichtenstein repair, which was successfully treated by mesh removal, orchiectomy and triple neurectomy. CASE PRESENTATION: A 65-year-old man was referred to our department because of chronic right orchialgia following Lichtenstein hernia repair...
2015: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/26344122/the-effect-of-methylprednisolone-and-tenoxicam-on-the-protection-of-damage-of-the-nerve-physiomorphology-caused-by-prolene-mesh
#19
Zeki Ozsoy, Huseyin Ayhan Kayaoglu, Namık Ozkan, Seyma Ozsoy, Faik Yaylak, Erdinc Yenidogan
INTRODUCTION: Aim was to investigate the effect of methylprednisolone and tenoxicam on the protection of damage of the nerve physiomorphology caused by prolene mesh used in hernia repair. METHODS: Fifty male Wistar-albino rats weighing 250-350 gr, were randomly divided into 5 groups. Sciatic nerve was dissected in all rats after performing EMG on basal neural transport. In group 1, only sciatic nerve manipulation was performed. Other groups received a monofilament polypropylene cuff around the sciatic nerve...
October 2015: International Journal of Surgery
https://www.readbyqxmd.com/read/26284803/-in-process-citation
#20
Laura Bognár, Örs Péter Horváth, Jenő Solt, Gábor Jancsó, András Vereczkei
CASE PRESENTATION: The authors report the case of a 68-year-old patient who presented with dysphagia 4 months after a mesh-reinforced antireflux surgery. Examinations revealed partial penetration of the mesh into the esophagus. During an expedited surgery, the mesh was removed through thoraco-laparotomy. Distal esophagus and proximal gastric resections were carried out due to longitudinal perforation site and esophageal stricture, and the continuity of the alimentary tract was restored with jejunal interposition...
August 2015: Magyar Sebészet
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