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Estrogen and hernia

Alper Sozutek, Oktay Irkorucu, Enver Reyhan, Kemal Yener, Ali Ayberk Besen, Kivilcim Eren Erdogan, Gulfiliz Gonlusen, Figen Doran
Aggressive angiomyxoma (AA) is an uncommon mesenchymal tumor that is mostly derived from the female pelvic and perineal regions. AA is a locally infiltrative slow growing tumor with a marked tendency to local recurrence. Painless swelling located around the genitofemoral region is the common symptom; thus, it is often misdiagnosed as a gynecological malignancy or a groin hernia. A 35-year-old female patient who previously underwent surgery for left femoral hernia operation resulting in surgical failure was reoperated for a giant AA located in the pelvis...
2016: Case Reports in Surgery
Xingzhe Ma, Ying Liu, Qixue Wang, Yuanli Chen, Mengyang Liu, Xiaoju Li, Rong Xiang, Yuquan Wei, Yajun Duan, Jihong Han
Hernia is a disease with defects in collagen synthesis/metabolism. However, the underlying mechanisms for hernia formation have not been fully defined. Tamoxifen is a selective estrogen receptor modulator and used for patients with breast cancer. Tamoxifen also has pleiotropic and side effects. Herein, we report that tamoxifen treatment resulted in an appearance of a large bulge in the low abdomen between the hind legs in male but not in female mice. The autopsy demonstrated that the low abdominal wall was broken and a large amount of intestine herniated out of the abdominal cavity...
May 2015: Biochimica et Biophysica Acta
Fadi I Jabr, Venk Mani
A rare case of abdominal pain secondary to endometriosis in a 52-year-old man with cirrhosis is presented. The patient had a repair of recurrent inguinal hernia 7 months prior to presentation. An exploratory laparotomy revealed a 4.5 cm × 2.5 cm cystic mass attached to the urinary bladder and the inguinal area. The mass pathology showed a cystic lumen of diameter of 1.5 cm filled with old blood and surrounded by thick muscular mass. Microscopically, the lesion consisted of thick smooth muscle fibers that concentrically surround a central lumen that is bordered by endometrium such as glands and stroma...
October 2014: Avicenna Journal of Medicine
Ajay Srivastava, Neel Patel
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of kidney disease. Enlarging cysts within the kidneys are the clinical hallmark of the disease. Renal manifestations include varying degrees of kidney injury, urinary tract infections, kidney stones, and hematuria. Extrarenal manifestations can include pain, hypertension, left ventricular hypertrophy, hepatic cysts, intracranial aneurysm, diverticulosis, and abdominal and inguinal hernias. The progression of ADPKD cannot be reversed with current treatment modalities; therefore, therapies target the resulting clinical manifestations...
September 1, 2014: American Family Physician
Raul S González, Cindy L Vnencak-Jones, Chanjuan Shi, Oluwole Fadare
Male endometriosis and endomyometriosis (also termed "uterus-like mass") are 2 unusual manifestations of endometriosis. We report a case of male endomyometriosis with immunohistochemical and molecular confirmation. A 52-year-old man presented with stabbing pelvic pain. Computed tomography scan showed a mass in the right inguinal area, at the site of prior hernia repair. The lesion was tubular in shape, with a thick muscular wall and a central blood-filled lumen. Microscopically, the tissue showed layers of concentric smooth muscle, with endometrial glands and stroma lining the lumen...
August 2014: International Journal of Surgical Pathology
Janet Chuang, Amy Vallerie, Lesley Breech, Howard M Saal, Shumyle Alam, Peggy Crawford, Meilan M Rutter
BACKGROUND: 17β-Hydroxysteroid dehydrogenase type-3 (17βHSD-3) deficiency is a rare cause of 46,XY disorders of sex development. The enzyme converts androstenedione to testosterone, necessary for masculinization of male genitalia in utero. 17βHSD-3 deficiency is frequently diagnosed late, at puberty, following virilization, with consequent female-to-male gender reassignment in 39-64%. The decision for sex of rearing is difficult, especially if diagnosed in early childhood. Consensus guidelines are equivocal or support male gender assignment...
September 12, 2013: International Journal of Pediatric Endocrinology
Adam Hermanowicz, Ewa Matuszczak, Wojciech Debek, Ewa Dzienis-Koronkiewicz, Marta Komarowska, Marzanna Oksiuta, Jolanta Kowalewska, Robert Milewski
BACKGROUND: The aim of this study was to assess the expression of estrogen receptors alpha and beta in paratesticular tissues in a group of boys with and without cryptorchidism, and evaluation of karyotypes, localization, morphology and the major length of the undescended testes. MATERIAL/METHODS: Fifty boys (1-4 years old) with unilateral cryptorchidism were evaluated. Fifty healthy boys within the same age range, with inguinal hernia, served as a control group...
October 2012: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Cem Dane, Aysegul Karaca, Ender Karaca, Banu Dane
BACKGROUND: 46,XY, or Swyer syndrome, is a complete gonadal dysgenesis. Patients usually presents with primary amenorrhea with underdeveloped secondary sex characteristics. Phenotypes of these patients are female. In this report, a Swyer syndrome case is reported with novel clinical features that are classified as connective tissue disorders. This case and the 2 other previously reported Swyer syndrome cases with ascendant aortic aneurysm and diaphragmatic hernia are suggest that the Y chromosome has an important role in the structure of connective tissue...
February 2013: Journal of Pediatric and Adolescent Gynecology
Brian J Sutton, Jennifer Laudadio
Aggressive angiomyxoma is a rare mesenchymal tumor that most commonly arises in the vulvovaginal region, perineum, and pelvis of women. The term aggressive emphasizes the often infiltrative nature of the tumor and its frequent association with local recurrence. Patients often present with nonspecific symptoms which are frequently misdiagnosed with more common entities, such as a Bartholin cyst, lipoma, or hernia. Histologic examination reveals a hypocellular and highly vascular tumor with a myxoid stroma containing cytologically bland stellate or spindled cells...
February 2012: Archives of Pathology & Laboratory Medicine
Niko Braun, Peter Fritz, Dagmar Biegger, Martin Kimmel, Fabian Reimold, Christoph Ulmer, M Dominik Alscher
OBJECTIVE: Encapsulating peritoneal sclerosis (EPS) is a rare but life-threatening complication of peritoneal dialysis (PD). The optimal management of patients with EPS is uncertain. In the present study, we investigated differences in the expression of nuclear receptors [progesterone (PR), androgen (AR), vitamin D (VDR), and glucocorticoid (GCR)] in the human peritoneum. We also investigated estrogen receptor (ER), matrix metalloproteinase 9 (MMP9), and transforming growth factor β1 (TGFβ1) in the context of their potential role in tamoxifen therapy...
May 2011: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Wei Lin, Nafis A Rahman, Jian Lin, Hua Zhang, Kemian Gou, Wanpeng Yu, Dahai Zhu, Ning Li, Ilpo Huhtaniemi, Xiangdong Li
We investigated the etiology and molecular mechanisms of bladder outlet obstruction (BOO). Transgenic (Tg) male mice overexpressing aromatase (Cyp19a1) under the ubiquitin C promoter in the estrogen-susceptible C57Bl/6J genetic background (AROM+/6J) developed inguinal hernia by 2 months and severe BOO by 9 to 10 months, with 100% penetrance. These mice gradually developed uremia, renal failure, renal retention, and finally died. The BOO bladders were threefold larger than in age-matched wild-type (WT) males and were filled with urine on necropsy...
March 2011: American Journal of Pathology
Gong Chen, Yinli Qiao, Xianmin Xiao, Shan Zheng, Lian Chen
PURPOSE: The study aimed to observe the influence of estradiol on rat models with congenital diaphragmatic hernia (CDH) and understand the potential mechanism. METHODS: Eleven pregnant female Sprague-Dawley rats were randomly divided into 3 groups on day 9.5 of gestation: group C (n = 2) was administered 2 mL of olive oil, whereas group N (n = 3) and group E (n = 6) were administered 200 mg of nitrofen. Antenatal estradiol was given subcutaneously to group E on days 18...
December 2010: Journal of Pediatric Surgery
M Dordevic, B Jovanovic, S Mitrovic, G Dordevic, D Radovanovic, P Sazdanovic
INTRODUCTION: Endometriosis is defined by the presence of functional endometrial tissue outside the uterus, where it is normally located. Endometriosis could has intra and extra pelvic localization. Abdominal endometriosis is the most common localization of extrapelvic endometriosis and is usually developed in the connective tissue surrounding the operation. Very rarely this could be found in the muscle tissue. The mechanical transplantation theory is responsible for the development of scar endometriosis...
2010: Bratislavské Lekárske Listy
Momcilo Dordević, Bozidar Jovanović, Slobodanka Mitrović, Gordana Dordević, Dragce Radovanović, Predrag Sazdanović
Endometriosis is defined by the presence of functional endometrial tissue outside the uterus, where it is normally located. Endometriosis is one of the most common gynecologic entities affecting 8%-18% of menstrual women. Endometriosis can occur at intra- and extrapelvic localizations. The most common intrapelvic localizations are those involving the ovaries, Douglas' area, pelvic peritoneum, uterus, bladder and rectum. Abdominal endometriosis is the most common localization of extrapelvic endometriosis and usually develops in connective tissue...
September 2009: Acta Clinica Croatica
Yves Pirson
Although asymptomatic in most patients, extrarenal manifestations of ADPKD may become more clinically relevant with the increasing life expectancy of affected patients. They mainly encompass cysts in other organs than the kidney (liver: 94%, seminal vesicle: 40%, pancreas: 9%, arachnoid membrane: 8%, and spinal meningeal, 2%) and connective tissue abnormalities (mitral valve prolapse: 25%, intracranial aneurysms: 8%, and abdominal hernia: 10%). Their recognition may spare the patient from other, useless investigations (eg, when an arachnoid cyst is incidentally found) or lead to the implementation of prophylactic or therapeutic measures (eg, screening, sometimes followed by the treatment of an asymptomatic intracranial aneurysm in at-risk patients, or, in the presence of a severe polycystic liver disease, avoidance from estrogens and treatment aimed to slow cyst growth)...
March 2010: Advances in Chronic Kidney Disease
Petra Sulentić, Slaven Abdović, Jaksa Filipović, Davor Tomas
A case of a very rare adipocytic tumor found during corrective surgery for incisional abdominal hernia is presented. Because of uterine leiomyomas the patient underwent total abdominal hysterectomy 14 years before. During surgery of incisional hernia, a part of small intestine along with a pedunculated tumor was found in hernial sac. The tumor was attached to the medial intra-abdominal peritoneum. On examination, the tumor presented as a totally encapsulated dimorphic benign neoplasm composed of mature adipocytes and well-differentiated smooth muscle cells...
June 2009: Acta Clinica Croatica
Tamás Józsa, Andrea Telek, Balázs Kutasy, Mátyás Benyó, Gábor Csanádi, Ilona Kovács, György Balla, Tibor Flaskó, László Csernoch, Csongor Kiss
The purpose of this study was to investigate the effects of an elevated hydrostatic pressure of hydrocele on the structural integrity and steroid receptor expression pattern of the appendix testis in children. Twenty-six testicular appendages were obtained from boys (aged between 13 and 79 months, mean 40 months) who underwent surgical exploration because of hydrocele or congenital inguinal hernia. The tissue sections of testicular appendages were stained with hematoxylin-eosin. Immunohistochemistry and immunofluorescence laser microscopy were performed using monoclonal mouse anti-human receptors against androgen and estrogen receptors...
November 2009: Asian Journal of Andrology
Michael S Hughes, Timothy A Burd, William C Allen
This article presents a unique case of posttraumatic extrapelvic endometriosis presenting as a gluteal mass causing cyclic sciatica. A 38-year-old woman presented with an enlarging right buttock mass over the previous 6 years. She also had symptoms of radicular pain referred to the right leg and foot with sitting and daily activity. Four years prior to noticing the mass, she sustained a gunshot wound through the lower abdomen while 5 months pregnant. Excisional biopsy of the gluteal mass revealed endometrioma...
April 2008: Orthopedics
Zhi-Qiang Du, Xia Zhao, Natascha Vukasinovic, Fernanda Rodriguez, Archie C Clutter, Max F Rothschild
Scrotal hernia in pigs is a complex trait likely affected by genetic and environmental factors. A large-scale association analysis of positional and functional candidate genes was conducted in four previously identified genomic regions linked to hernia susceptibility on Sus scrofa chromosomes 2 and 12, as well as the fifth region around 67 cM on chromosome 2, respectively. In total, 151 out of 416 SNPs discovered were genotyped successfully. Using a family-based analysis we found that four regions surrounding ELF5, KIF18A, COL23A1 on chromosome 2, and NPTX1 on chromosome 12, respectively, may contain the genetic variants important for the development of the scrotal hernia in pigs...
2009: PloS One
R M Paredes Esteban, R J Luque Barona, B Velasco Sánchez, J Rodríguez Vargas, A Lorite, M García Ruiz
INTRODUCTION: The appendices or hidátides of the testicle are structures that are considered an embryonic rest. In testicular hidátide estrogen receivers have been demonstrated but in the epididimys the results vary. Has been theorized that the elevation of the estrogen levels in the puberty can produce an inflammation and torsion of hidátide, nevertheless, in the epididimys in which the estrogen expression is not clear (and also they are twisted) the theory is put in doubt. This controversy takes us to the accomplishment of this work...
July 2008: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
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