Thorhildur Olafsdottir, Gudmar Thorleifsson, Patrick Sulem, Olafur A Stefansson, Helga Medek, Karl Olafsson, Orri Ingthorsson, Valur Gudmundsson, Ingileif Jonsdottir, Gisli H Halldorsson, Ragnar P Kristjansson, Michael L Frigge, Lilja Stefansdottir, Jon K Sigurdsson, Asmundur Oddsson, Asgeir Sigurdsson, Hannes P Eggertsson, Pall Melsted, Bjarni V Halldorsson, Sigrun H Lund, Unnur Styrkarsdottir, Valgerdur Steinthorsdottir, Julius Gudmundsson, Hilma Holm, Vinicius Tragante, Folkert W Asselbergs, Unnur Thorsteinsdottir, Daniel F Gudbjartsson, Kristin Jonsdottir, Thorunn Rafnar, Kari Stefansson
Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs, resulting in a protrusion of the vaginal wall and/or uterus. We performed a genome-wide association study of POP using data from Iceland and the UK Biobank, a total of 15,010 cases with hospital-based diagnosis code and 340,734 female controls, and found eight sequence variants at seven loci associating with POP (P < 5 × 10-8 ); seven common (minor allele frequency >5%) and one with minor allele frequency of 4...
March 17, 2020: Communications Biology