keyword
MENU ▼
Read by QxMD icon Read
search

Obesity and breast cancer

keyword
https://www.readbyqxmd.com/read/28342988/an-anti-inflammatory-dietary-intervention-to-reduce-breast-cancer-recurrence-risk-study-design-and-baseline-data
#1
Amelie G Ramirez, Dorothy Long Parma, Edgar Muñoz, Kristin D Mendoza, Crystel Harb, Alan E C Holden, Michael Wargovich
U.S. breast cancer survivors (BCSs) are expected to increase to 4 million in the next 5-10years. Cancer recurrence risk is highest among obese survivors. Inflammatory (Pro-I) biomarkers including C-reactive protein (CRP), Interleukins -3, -6, and -8 (IL-3, IL-6, IL-8), and Tumor Necrosis Factor (TNF)-α have been associated with cancer recurrence risk. Nutritional interventions aimed at reducing inflammation (INF) may contribute to reduced cancer recurrence risk, but studies have been limited to animal models...
March 22, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28335697/investigation-of-a-lifestyle-intervention-in-women-at-high-risk-of-breast-cancer
#2
Claire J Han, Larissa A Korde, Scott Reding, Kristen Allott, Matt Van Doren, Yvonne Schwarz, Catalina Vaughan, Kerryn W Reding
One fourth of breast cancer can be attributed to sedentary lifestyles and being overweight or obese. This pilot study was conducted to explore whether a 6-month lifestyle intervention affected body composition and obesity-related biomarkers among women at high risk of breast cancer. Overweight/obese women at high risk of breast cancer were randomized to the control group or to the intervention. The intervention was an individually tailored, cognitive-behavioral therapy program that assists women in identifying strategies to improve their nutrition and physical activity habits with the goal of reduced adiposity...
March 1, 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28335515/dehydroepiandrosterone-dhea-feeding-protects-liver-steatosis-in-obese-breast-cancer-rat-model
#3
Reza Hakkak, Andrea Bell, Soheila Korourian
Obesity is a major health problem in the US and globally. Obesity is associated with the risk of cardiovascular disease, type 2 diabetes, cancers, hyperlipidemia, and liver steatosis development. Dehydroepiandrosterone (DHEA) is a dietary supplement used as an anti-obesity supplement. Previously, we reported that DHEA feeding protects 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors. The objectives of this study were to investigate the effects of obesity and DHEA feeding on liver steatosis, body weight gain, and serum DHEA, DHEA sulfate (DHEA-S), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein-3 (IGFBP-3) levels...
March 20, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28330687/adipocyte-tumor-cell-metabolic-crosstalk-in-breast-cancer
#4
REVIEW
Andrew J Hoy, Seher Balaban, Darren N Saunders
The tumor stroma is a heterogeneous ecosystem comprising matrix, fibroblasts, and immune cells and has an important role in cancer progression. Adipocytes constitute a major component of breast stroma, and significant emerging evidence demonstrates a reciprocal metabolic adaptation between stromal adipocytes and breast cancer (BC) cells. Recent observations promote a model where adipocytes respond to cancer cell-derived endocrine and paracrine signaling to provide metabolic substrates, which in turn drive enhanced cancer cell proliferation, invasion, and treatment resistance...
March 19, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28323914/menopause-is-a-determinant-of-breast-aromatase-expression-and-its-associations-with-bmi-inflammation-and-systemic-markers
#5
Kristy A Brown, Neil M Iyengar, Xi Kathy Zhou, Ayca Gucalp, Kotha Subbaramaiah, Hanhan Wang, Dilip D Giri, Monica Morrow, Domenick J Falcone, Nils K Wendel, Lisle A Winston, Michael Pollak, Anneloor Dierickx, Clifford A Hudis, Andrew J Dannenberg
CONTEXT: Most estrogen-dependent breast cancers occur after menopause despite low levels of circulating estrogens. Breast expression of the estrogen-biosynthetic enzyme, aromatase, is proposed to drive breast cancer development after menopause. However, the effects of menopause on breast aromatase expression are unknown. OBJECTIVE: To determine the effect of menopause on breast aromatase expression in relation to body mass index (BMI), white adipose tissue inflammation (WATi) and systemic markers of metabolic dysfunction...
February 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28322524/-nudging-o-educazione-a-scelte-civiche-responsabili-l-esempio-dello-screening-della-mammella
#6
Mariachiara Tallacchini
"Nudge, or nudging, refers to a policy approach inspired by behavioral sciences: it promotes the conducts identified as desirable by regulators without applying prohibition and coercion. This approach has gained a lot of momentum in the domain of health policies. Policy strategies based on behavioral insights appear ideal as to implementing healthier life styles and public health programs while minimizing compliance costs: from organ donation to food choices, from fighting obesity and chronic diseases to screening policies...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28302993/content-analysis-of-news-coverage-on-cancer-prevention-and-screening-in-japanese-newspapers
#7
Rina Miyawaki, Kaori Ishii, Ai Shibata, Koichiro Oka
Objectives The present study investigated articles on cancer prevention published in Japanese newspapers in 2011.Methods A content analysis of news coverage on cancer primary prevention and screening was conducted. Articles which mentioned cancer risk, prevention, and screening were extracted. For all articles on prevention, the newspaper's name, month of publication, and information source were checked. Coding variables for articles on primary prevention included causes of human cancer, risk and/or prevention, and recommended screening criteria...
2017: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://www.readbyqxmd.com/read/28295245/body-mass-index-pam50-subtype-recurrence-and-survival-among-patients-with-nonmetastatic-breast-cancer
#8
Elizabeth M Cespedes Feliciano, Marilyn L Kwan, Lawrence H Kushi, Wendy Y Chen, Erin K Weltzien, Adrienne L Castillo, Carol Sweeney, Philip S Bernard, Bette J Caan
BACKGROUND: Studies of obesity and survival among patients with breast cancer produce conflicting results, possibly because of heterogeneity by molecular subtype. METHODS: This study examined whether the association of body mass index (BMI) at diagnosis with breast cancer recurrence and survival varied across subtypes defined by PAM50 (Prediction Analysis of Microarray 50) gene expression. Included were 1559 Kaiser Permanente Northern California members ages 18 to 79 years who had PAM50 assays and were diagnosed with American Joint Committee on Cancer stage I through III breast cancer from 1996 to 2013...
March 13, 2017: Cancer
https://www.readbyqxmd.com/read/28293912/breast-cancer-subtype-distribution-is-different-in-normal-weight-overweight-and-obese-women
#9
Victoria Gershuni, Yun R Li, Austin D Williams, Alycia So, Laura Steel, Elena Carrigan, Julia Tchou
PURPOSE: Obesity is associated with tumor promoting pathways related to insulin resistance and chronic low-grade inflammation which have been linked to various disease states, including cancer. Many studies have focused on the relationship between obesity and increased estrogen production, which contributes to the pathogenesis of estrogen receptor-positive breast cancers. The link between obesity and other breast cancer subtypes, such as triple-negative breast cancer (TNBC) and Her2/neu+ (Her2+) breast cancer, is less clear...
March 14, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28293621/development-of-the-physical-activity-and-your-nutrition-for-cancer-pync-smartphone-app-for-preventing-breast-cancer-in-women
#10
Steven S Coughlin, Gina M Besenyi, Deborah Bowen, Gianluca De Leo
BACKGROUND: In the U.S., breast cancer accounts for more cancer deaths in women than any site other than lung cancer. Based upon attributable risks, about 30-35% of breast cancers could potentially be prevented by addressing obesity, physical inactivity, increased alcohol consumption, and carcinogenic exposures such as hormone replacement therapy (HRT). We need methods of reducing women's risks of this disease that are attractive and easy to use, widely accessible to diverse women, and able to be easily amended to account for new research...
2017: MHealth
https://www.readbyqxmd.com/read/28292922/the-association-of-the-c-reactive-protein-inflammatory-biomarker-with-breast-cancer-incidence-and-mortality-in-the-women-s-health-initiative
#11
Sandahl H Nelson, Theodore M Brasky, Ruth E Patterson, Gail A Laughlin, Donna Kritz-Silverstein, Beatrice J Edwards, Dorothy Lane, Thomas E Rohan, Gloria Y F Ho, JoAnn E Manson, Andrea Z LaCroix
PURPOSE: To examine associations of pre-diagnosis high-sensitivity C-reactive (hsCRP) with breast cancer incidence and post-diagnosis survival and to assess whether associations are modified by Body Mass Index (BMI). METHODS: A prospective analysis of the Women's Health Initiative was conducted among 17,841 cancer free postmenopausal women with baseline hsCRP measurements. Cox proportional hazards models were used to examine associations between hsCRP concentrations and: 1) breast cancer risk (n cases=1,114) and 2) all-cause mortality after breast cancer diagnosis...
March 14, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28290007/impact-of-urban-neighborhood-disadvantage-on-late-stage-breast-cancer-diagnosis-in-virginia
#12
Pam Baker DeGuzman, Wendy F Cohn, Fabian Camacho, Brandy L Edwards, Vanessa N Sturz, Anneke T Schroen
Research suggests that residents of inner-city urban neighborhoods have higher rates of late stage cancer diagnosis. Identifying urban neighborhoods with high rates of both concentrated disadvantage and late stage cancer diagnosis may assist health care providers to target screening interventions to reduce disparities. The purposes of this study were to (1) create an index to evaluate concentrated disadvantage (CD) using non-racial measures of poverty, (2) determine the impact of neighborhood CD on late stage breast cancer diagnosis in US cities, and (3) to understand the role of obesity on this relationship...
March 13, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28287627/plasma-free-amino-acid-profiles-are-predictors-of-cancer-and-diabetes-development
#13
REVIEW
X Bi, C J Henry
Type 2 diabetes (T2D) and cancers are two major causes of morbidity and mortality worldwide. Nowadays, there is convincing evidence of positive associations between T2D and the incidence or prognosis of a wide spectrum of cancers, for example, breast, colon, liver and pancreas. Many observational studies suggest that certain medications used to treat hyperglycemia (or T2D) may affect cancer cells directly or indirectly. The potential mechanisms of the direct T2D cancer links have been hypothesized to be hyperinsulinemia, hyperglycemia and chronic inflammation; however, the metabolic pathways that lead to T2D and cancers still remain elusive...
March 13, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28283875/prevalence-and-correlates-of-patient-reported-symptoms-and-comorbidities-in-breast-cancer-survivors-at-a-tertiary-center
#14
Moaath Mustafa Ali, Machelle Moeller, Lisa Rybicki, Halle C F Moore
PURPOSE: Survivorship care is an essential component in the management of cancer patients. Optimal delivery of survivorship care requires an understanding of patient concerns and factors associated with treatment-related symptoms and comorbidities. METHODS: We conducted a retrospective cohort study evaluating 34 patient-reported conditions (symptoms and comorbidities) as well as self-reported health habits of stage 0-III breast cancer patients using a questionnaire completed at the time of the initial survivorship visit (SV)...
March 10, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28279068/%C3%AE-catenin-mediates-anti-adipogenic-and-anticancer-effects-of-arctigenin-in-preadipocytes-and-breast-cancer-cells
#15
Jihye Lee, Jee-Young Imm, Seong-Ho Lee
Arctigenin is a lignan abundant in Asteraceae plants and has anti-inflammatory, antiobesity, and anticancer activities. Obesity is one of the leading causes of several types of cancers including breast cancer. The current study was performed to investigate if arctigenin suppresses differentiation of preadipocytes and proliferation of breast cancer cells and to explore potential molecular mechanisms. Treatment of arctigenin reduced lipid accumulation in differentiated 3T3-L1 adipocytes in a dose- and time-dependent manner without toxicity...
March 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28277986/bardoxolone-methyl-inhibits-migration-and-metabolism-in-mcf7-cells
#16
Alaa Refaat, Chathyan Pararasa, Muhammed Arif, James E P Brown, Amtul Carmichael, Sameh S Ali, Hiroaki Sakurai, Helen R Griffiths
Bardoxolone-methyl (BAR) is reported to have anti-inflammatory, anti-proliferative and anti-fibrotic effects. BAR activates Nrf2 and may ameliorate oxidative stress through induction of antioxidant genes. However, off-target effects, probably concentration and NFkB-dependent, have limited the clinical use of BAR. Nrf2 regulates expression of antioxidant and mitochondrial genes and has been proposed as a target for both obesity and breast cancer. Therefore, we explored whether BAR can alter migration and proliferation in the MCF7 cell line and whether metabolic function is affected by BAR...
February 2017: Free Radical Research
https://www.readbyqxmd.com/read/28274935/crown-like-structures-in-breast-adipose-tissue-from-normal-weight-women-significant-impact
#17
Nathan A Berger
Crown-like structures (CLS), composed of macrophages surrounding dead or dying adipocytes, are a histologic hallmark of the pro-inflammatory process by which adipose tissue contributes to the increased risk and worse prognosis of breast cancer in obese, post menopausal patients. In this issue of Cancer Prevention Research, Iyengar et al report the intriguing finding that CLS, can be identified in a significant proportion of normal BMI women undergoing mastectomy for breast cancer risk reduction or therapy (1)...
March 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28270386/metabolic-obesity-adipose-inflammation-and-elevated-breast-aromatase-in-women-with-normal-body-mass-index
#18
Neil M Iyengar, Kristy A Brown, Xi Kathy Zhou, Ayca Gucalp, Kotha Subbaramaiah, Dilip D Giri, Heba Zahid, Priya Bhardwaj, Nils K Wendel, Domenick J Falcone, Hanhan Wang, Samantha Williams, Michael Pollak, Monica Morrow, Clifford A Hudis, Andrew J Dannenberg
Obesity is associated with breast white adipose tissue (WAT) inflammation, elevated levels of the estrogen biosynthetic enzyme, aromatase, and systemic changes that have been linked to the pathogenesis of breast cancer. Here, we determined whether metabolic obesity, including changes in breast biology and systemic effects, occurs in a subset of women with normal body mass index (BMI). Breast WAT and fasting blood were collected from 72 women with normal BMI (<25 kg/m(2)) undergoing mastectomy for breast cancer risk reduction or treatment...
March 7, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28268252/the-association-between-metabolic-health-obesity-phenotype-and-the-risk-of-breast-cancer
#19
Yong-Moon Mark Park, Alexandra J White, Hazel B Nichols, Katie M O'Brien, Clarice R Weinberg, Dale P Sandler
Beyond the current emphasis on body mass index (BMI), it is unknown whether breast cancer risk differs between metabolically healthy and unhealthy normal weight or overweight/obese women. The Sister Study is a nationwide prospective cohort study. Data came from 50,884 cohort participants aged 35 to 74 years enrolled from 2003 through 2009. Cox proportional hazards models were used to estimate multivariable adjusted hazard ratios (HR) and 95% confidence intervals (CIs) for breast cancer risk. Metabolic abnormalities considered included: high waist circumference (≥88 cm); elevated blood pressure (≥130/85 mm Hg or antihypertensive medication); previously diagnosed diabetes or antidiabetic drug treatment; and cholesterol-lowering medication use...
March 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28265721/association-between-type-2-diabetes-and-risk-of-cancer-mortality-a-pooled-analysis-of-over-771-000-individuals-in-the-asia-cohort-consortium
#20
Yu Chen, Fen Wu, Eiko Saito, Yingsong Lin, Minkyo Song, Hung N Luu, Prakash C Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Woon-Puay Koh, Yong-Bing Xiang, Yasutake Tomata, Kemmyo Sugiyama, Sue K Park, Keitaro Matsuo, Chisato Nagata, Yumi Sugawara, You-Lin Qiao, San-Lin You, Renwei Wang, Myung-Hee Shin, Wen-Harn Pan, Mangesh S Pednekar, Shoichiro Tsugane, Hui Cai, Jian-Min Yuan, Yu-Tang Gao, Ichiro Tsuji, Seiki Kanemura, Hidemi Ito, Keiko Wada, Yoon-Ok Ahn, Keun-Young Yoo, Habibul Ahsan, Kee Seng Chia, Paolo Boffetta, Wei Zheng, Manami Inoue, Daehee Kang, John D Potter
AIMS/HYPOTHESIS: The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. METHODS: Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia...
March 7, 2017: Diabetologia
keyword
keyword
48354
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"