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Obesity and breast cancer

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https://www.readbyqxmd.com/read/29235933/faster-ticking-rate-of-the-epigenetic-clock-is-associated-with-faster-pubertal-development-in-girls
#1
Alexandra M Binder, Camila Corvalan, Verónica Mericq, Ana Pereira, José Luis Santos, Steve Horvath, John Shepherd, Karin B Michels
Epigenetic age is an indicator of biological aging, capturing the impact of environmental and behavioral influences across time on cellular function. Deviance between epigenetic age and chronological age (AgeAccel) is a predictor of health. Pubertal timing has similarly been associated with cancer risk and mortality rate among females. We examined the association between AgeAccel and pubertal timing and adolescent breast composition in the longitudinal Growth and Obesity Cohort Study. AgeAccel was estimated in whole blood using the Horvath method at breast Tanner 2 (B2) and 4 (B4)...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29234710/polypoid-endometriosis-mimicking-invasive-cancer-in-an-obese-postmenopausal-tamoxifen-user
#2
William T Jaegle, Jason C Barnett, Bridget R Stralka, Nicole P Chappell
Background: Tamoxifen is a medication often used for the treatment and prevention of breast cancer. It is classically associated with several gynecological side effects to include a thickened endometrial stripe, increased uterine polyp formation, and an increased risk of uterine cancer. Rarely tamoxifen use has been associated with proliferation of endometriosis often severe enough to mimic a late-stage gynecologic malignancy. Case: A 62-year-old Gravida 0 postmenopausal female with a medical history of severe obesity, infertility, and preventative tamoxifen use presented for evaluation of gross hematuria...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29234306/body-mass-index-influences-the-prognostic-impact-of-combined-nuclear-insulin-receptor-and-estrogen-receptor-expression-in-primary-breast-cancer
#3
Sofie Björner, Ann H Rosendahl, Maria Simonsson, Andrea Markkula, Karin Jirström, Signe Borgquist, Carsten Rose, Christian Ingvar, Helena Jernström
The prognostic importance of tumor-specific nuclear insulin receptor (InsR) expression in breast cancer is unclear, while membrane and cytoplasmic localization of InsR is better characterized. The insulin signaling network is influenced by obesity and may interact with the estrogen receptor α (ERα) signaling. The purpose was to investigate the interplay between nuclear InsR, ER, body mass index (BMI), and prognosis. Tumor-specific expression of nuclear InsR was evaluated by immunohistochemistry in tissue microarrays from 900 patients with primary invasive breast cancer without preoperative treatment, included in a population-based cohort in Sweden (2002-2012) in relation to prognosis...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29233548/the-impact-of-actual-body-weight-based-chemotherapy-dosing-and-body-size-on-adverse-events-and-outcome-in-older-patients-with-breast-cancer-results-from-cancer-and-leukemia-group-b-calgb-trial-49907-alliance-a151436
#4
Vicki A Morrison, Linda McCall, Hyman B Muss, Aminah Jatoi, Harvey J Cohen, Constance T Cirrincione, Jennifer A Ligibel, Jacqueline M Lafky, Arti Hurria
OBJECTIVE: Actual weight-based (AWB) chemotherapy dosing is recommended for obese patients in the 2012 ASCO Clinical Practice Guideline. CALGB 49907, which utilized ABW-based adjuvant chemotherapy dosing, was a phase 3 trial in women age≥65years with early stage breast cancer, providing the opportunity to examine impact of such dosing on toxicities and outcome in older patients with breast cancer. MATERIALS AND METHODS: Adverse event data were available for 615 of 633 enrolled patients...
December 7, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29228687/interactions-between-rasa2-cadm1-hif1an-gene-polymorphisms-and-body-fatness-with-breast-cancer-a-population-based-case-control-study-in-china
#5
Zheng Zhu, Zhimei Teng, Fränzel J B van Duijnhoven, Meihua Dong, Yun Qian, Hao Yu, Jie Yang, Renqiang Han, Jian Su, Wencong Du, Xingyu Huang, Jinyi Zhou, Xiaojin Yu, Ellen Kampman, Ming Wu
Genome-wide association studies (GWAS) have indicated that gene polymorphisms in alleles of RAS p21 protein activator 2 (RASA2), cell adhesion molecule 1 (CADM1) and hypoxia inducible factor 1 alpha subunit inhibitor (HIF1AN) are associated with the risk of obesity. In this study, we explored the interactions between candidate SNPs of RASA2 (rs16851483), CADM1 (rs12286929) and HIF1AN (rs17094222) and body fatness for breast cancer risk. Unconditional logistic regression models were applied to measure the associations of related factors with breast cancer by odds ratios (ORs) and 95% confidence intervals (CIs)...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29225112/fisetin-a-bioactive-phytochemical-with-potential-for-cancer-prevention-and-pharmacotherapy
#6
REVIEW
Dharambir Kashyap, Ajay Sharma, Katrin Sak, Hardeep Singh Tuli, Harpal Singh Buttar, Anupam Bishayee
A wide variety of chronic diseases, such as neurodegenerative and cardiovascular disorders, diabetes mellitus, osteoarthtitis, obesity and various cancers, are now being treated with cost effective phytomedicines. Since synthetic medicines are very expensive, concerted efforts are being made in developing and poor countries to discover cost effective medicines for the treatment of non-communicable diseases (NCDs). Understanding the underlying mechanisms of bioactive medicines from natural sources would not only open incipient avenues for the scientific community and pharmaceutical industry to discover new drug molecules for the therapy of NCDs, but also help to garner knowledge for alternative therapeutic approaches for the management of chronic diseases...
December 7, 2017: Life Sciences
https://www.readbyqxmd.com/read/29223303/influence-of-body-habitus-on-dose-parameters-of-nodal-levels-iii-to-iv-irradiation-for-breast-cancer-comparison-of-3-techniques
#7
Sebastia Sabater, Marina Gascon, Manuel Gutierrez-Perez, Roberto Berenguer, Ellen M Donovan, Emma J Harris, Meritxell Arenas
This study aimed to investigate the effect of body habitus on supraclavicular (SC) dose-volume histogram (DVH) parameters among breast cancer patients according to 3 different techniques. Three SC irradiation plans were generated for 24 postoperative breast cancer patients: (1) direct antero-posterior field only (1fieldP), with dose prescribed to a 3-cm depth; (2) 3-cm depth plan (3cmP) using an antero-posterior field plus a posterior boost with the dose prescription defined to 3 cm; and (3) optimized plan (OptP) similar to 3cmP, with dose prescribed depending on the anatomy...
December 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29222346/adiposity-inflammation-and-breast-cancer-pathogenesis-in-asian-women
#8
Neil M Iyengar, I-Chun Chen, Xi K Zhou, Dilip D Giri, Domenick J Falcone, Lisle A Winston, Hanhan Wang, Samantha Williams, Yen-Shen Lu, Tsu-Hsin Hsueh, Ann-Lii Cheng, Clifford A Hudis, Ching-Hung Lin, Andrew J Dannenberg
Obesity is associated with white adipose tissue (WAT) inflammation in the breast, elevated levels of the estrogen biosynthetic enzyme, aromatase, and systemic changes that predispose to breast cancer development. We examined whether WAT inflammation and its associated systemic effects correlate with body fat levels in an Asian population where body mass index (BMI) is not an accurate assessment of obesity and cancer risk. We also investigated whether biologic differences could account for the greater proportion of premenopausal estrogen receptor (ER)-positive breast cancer in Asian versus western countries...
December 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29220587/fto-gene-affects-obesity-and-breast-cancer-through-similar-mechanisms-a-new-insight-into-the-molecular-therapeutic-targets
#9
M E Akbari, M Gholamalizadeh, S Doaei, F Mirsafa
OBJECTIVES: This review focused on the possible mediatory role of the FTO in the association between obesity and breast cancer. METHOD: All articles published in English from June 1990 to January 2017 were studied. The search terms used were FTO gene, FTO polymorphism, breast cancer, and obesity. Inclusion criteria consisted of assessment of the relationship between FTO polymorphisms and/or FTO expression level with obesity and/or breast cancer as a primary outcome...
December 8, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29217518/enhancement-of-mammary-tumor-growth-by-igfbp-3-involves-impaired-t-cell-accumulation
#10
Tiffany Scully, Carolyn Scott, Sue Mei Firth, Lisa M Sedger, John E Pintar, Stephen Twigg, Robert C Baxter
Epidemiological studies show an association between obesity and poor breast cancer prognosis. We previously demonstrated that global IGFBP-3 deficiency, in IGFBP-3-null mice, resulted in a 50% reduction in mammary tumor growth over 3 weeks relative to tumors in wild-type C57BL/6 mice. This growth reduction was ameliorated by high-fat feeding-induced obesity. This study aimed to examine how IGFBP-3 promotes tumor growth by influencing the immune tumor microenvironment in healthy and obese mice. Syngeneic EO771 cells, which lack detectable IGFBP-3 expression, were grown as orthotopic tumors in wild-type and IGFBP-3-null C57BL/6 mice placed on either a control chow or high-fat diet, and examined by quantitative PCR and immunohistochemistry...
December 7, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29216352/identification-of-estrogen-related-receptor-alpha-agonists-in-the-tox21-compound-library
#11
Caitlin Lynch, Jinghua Zhao, Ruili Huang, Noriko Kanaya, Lauren Bernal, Jui-Hua Hsieh, Scott S Auerbach, Kristine L Witt, B Alex Merrick, Shiuan Chen, Christina T Teng, Menghang Xia
The estrogen-related receptor alpha (ERRα) is an orphan nuclear receptor (NR) that plays a role in energy homeostasis and controls mitochondrial oxidative respiration. Increased expression of ERRα in certain ovarian, breast, and colon cancers has a negative prognosis, indicating an important role for ERRα in cancer progression. An interaction between ERRα and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) has also recently been shown to regulate an enzyme in the β-oxidation of free fatty acids, thereby suggesting that ERRα plays an important role in obesity and type 2 diabetes...
December 4, 2017: Endocrinology
https://www.readbyqxmd.com/read/29197994/serum-lipids-and-risk-of-obesity-related-cancers-in-postmenopausal-women
#12
Geoffrey C Kabat, Mimi Y Kim, Rowan T Chlebowski, Mara Z Vitolins, Sylvia Wassertheil-Smoller, Thomas E Rohan
PURPOSE: Obesity, which is commonly accompanied by dyslipidemia, is associated with an increased risk of certain cancers. However, the association of serum lipids with specific obesity-related cancers is unclear. METHODS: We examined the association of baseline lipids (total cholesterol, low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglycerides) with risk of developing seven obesity-related cancers in a subcohort of 24,208 participants in the Women's Health Initiative...
December 2, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29197120/resveratrol-inhibits-obesity-associated-adipose-tissue-dysfunction-and-tumor-growth-in-a-mouse-model-of-postmenopausal-claudin-low-breast-cancer
#13
Emily L Rossi, Subreen A Khatib, Steven S Doerstling, Laura W Bowers, Melissa Pruski, Nikki A Ford, Randolph D Glickman, Mengmeng Niu, Peiying Yang, Zhengrong Cui, John DiGiovanni, Stephen D Hursting
Adipose tissue dysregulation, a hallmark of obesity, contributes to a chronic state of low-grade inflammation and is associated with increased risk and progression of several breast cancer subtypes, including claudin-low breast tumors. Unfortunately, mechanistic targets for breaking the links between obesity-associated adipose tissue dysfunction, inflammation, and claudin-low breast cancer growth have not been elucidated. Ovariectomized female C57BL/6 mice were randomized (n = 15/group) to receive a control diet, a diet-induced obesity (DIO) diet, or a DIO + resveratrol (0...
November 20, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29191261/do-cancer-related-fatigue-and-physical-activity-vary-by-age-for-black-women-with-a-history-of-breast-cancer
#14
Melody Swen, Amandeep Mann, Raheem J Paxton, Lorraine T Dean
INTRODUCTION: Cancer-related fatigue (CRF) is the most uncomfortable symptom among women with a history of breast cancer. Black women are more likely than women of other racial/ethnic groups to have CRF risk factors, such as physical inactivity and obesity, yet CRF studies have not focused on black women. We conducted a cross-sectional analysis to assess CRF and physical activity among black women survivors of breast cancer. METHOD: In May and July of 2012, 267 members (mean age, 54 y) of the Sisters Network, Inc, completed an online survey of sociodemographic characteristics, medical characteristics, and physical activity, and a fatigue instrument (the Functional Assessment of Chronic Illness Therapy [FACIT])...
November 30, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29187227/obesity-reversibly-depletes-the-basal-cell-population-and-enhances-mammary-epithelial-cell-estrogen-receptor-alpha-expression-and-progenitor-activity
#15
Tamara Chamberlin, Joseph V D'Amato, Lisa M Arendt
BACKGROUND: Obesity is correlated with an increased risk for developing postmenopausal breast cancer. Since obesity rates continue to rise worldwide, it is important to understand how the obese microenvironment influences normal mammary tissue to increase breast cancer risk. We hypothesized that obesity increases the proportion of luminal progenitor cells, which are thought to be the cells of origin for the most common types of breast cancer, potentially leading to an increased risk for breast cancer...
November 29, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29181851/life-course-evolution-of-body-size-and-breast-cancer-survival-in-the-e3n-cohort
#16
Mathilde His, Marine Le Guélennec, Sylvie Mesrine, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Guy Fagherazzi, Laure Dossus
Although adult obesity has been associated with poor breast cancer survival, data on adiposity at different periods in life and its lifelong evolution are scarce. Our aims were to assess the associations between breast cancer survival and body size during childhood, puberty, and early adulthood and body size trajectories from childhood to adulthood. Self-assessed body size at age 8, at puberty, at age 20-25, and at age 35-40 and trajectories of body size of 4 662 breast cancer survivors from the prospective E3N cohort were studied in relation to risk of death from any cause, death from breast cancer and second invasive cancer event using multivariate Cox regression models...
November 27, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29181100/kinesin-family-member-11-contributes-to-the-progression-and-prognosis-of-human-breast-cancer
#17
Yuan-Yuan Pei, Gao-Chi Li, Jian Ran, Feng-Xiang Wei
The present study aimed to clarify the association between kinesin family member 11 (KIF11) and human breast cancer, and the effect of KIF11 on breast cancer cell progression. Western blot analysis, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis, retroviral infection, immunohistochemistry staining, MTT assay, anchorage-independent growth ability assay and tumorigenicity assay were all used in the present study. Western blot and RT-qPCR analysis revealed that the expression of KIF11 was markedly increased in malignant cells compared with that in non-tumorous cells at the mRNA and protein level...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29176410/the-impact-of-autologous-breast-reconstruction-on-body-mass-index-patterns-in-breast-cancer-patients-a-propensity-matched-analysis
#18
Eugenia H Cho, Ronnie L Shammas, Adam D Glener, Rachel A Greenup, E Shelley Hwang, Scott T Hollenbeck
BACKGROUND: Weight gain is common in breast cancer patients and increases the risk of recurrence and mortality. The authors assessed the impact of autologous breast reconstruction on body mass index patterns after diagnosis in mastectomy patients. METHODS: Women undergoing therapeutic mastectomy at the authors' institution from 2008 to 2010 were identified. Patients undergoing no breast reconstruction or autologous breast reconstruction were propensity-matched by age at diagnosis, baseline obesity, mastectomy laterality, and adjuvant therapies...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29172285/body-mass-index-and-breast-cancer-risk-among-thai-premenopausal-women-a-case-control-study
#19
Wisit Chaveepojnkamjorn, Rungsinoppadol Thotong, Pratana Sativipawee, Supachai Pitikultang
Background: Breast cancer (BC) is the leading malignancy in women with high incidence and mortality worldwide. Obesity is one of several established risk factors for chronic diseases including cancer. The objective of this research was to determine the association of body mass index (BMI) with BC among Thai premenopausal women (TPW). Materials and Methods: A case-control study was conducted among TPW attending the National Cancer Institute in Bangkok, with 257 cases and 257 controls in 2013-2014. Cases and controls were matched by age (± 5 years), residential area and duration of attending...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29168064/adipose-tissue-inflammation-in-breast-cancer-survivors-effects-of-a-16-week-combined-aerobic-and-resistance-exercise-training-intervention
#20
Christina M Dieli-Conwright, Jean-Hugues Parmentier, Nathalie Sami, Kyuwan Lee, Darcy Spicer, Wendy J Mack, Fred Sattler, Steven D Mittelman
PURPOSE: Obesity is a leading modifiable contributor to breast cancer mortality due to its association with increased recurrence and decreased overall survival rate. Obesity stimulates cancer progression through chronic, low-grade inflammation in white adipose tissue, leading to accumulation of adipose tissue macrophages (ATMs), in particular, the pro-inflammatory M1 phenotype macrophage. Exercise has been shown to reduce M1 ATMs and increase the more anti-inflammatory M2 ATMs in obese adults...
November 22, 2017: Breast Cancer Research and Treatment
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