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Obesity and breast cancer

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https://www.readbyqxmd.com/read/29673794/difference-in-risk-of-breast-and-ovarian-cancer-according-to-putative-functional-domain-regions-in-korean-brca1-2-mutation-carriers
#1
Ji Soo Park, Seung-Tae Lee, Jung Woo Han, Tae Il Kim, Eun Ji Nam, Hyung Seok Park
INTRODUCTION: We investigated the relative risk of breast and ovarian cancers related to the putative functional domain regions, obesity, and parity among Korean BRCA1/2 mutation carriers. PATIENTS AND METHODS: We analyzed the clinical characteristics, cancer history, and mutations according to the putative functional domain of BRCA proteins among 229 women with BRCA1/2 mutations who were treated at Yonsei Cancer Center, Severance Hospital between January 2009 and March 2017...
February 20, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29668675/correlated-metabolomic-genomic-and-histologic-phenotypes-in-histologically-normal-breast-tissue
#2
Xuezheng Sun, Delisha A Stewart, Rupninder Sandhu, Erin L Kirk, Wimal W Pathmasiri, Susan L McRitchie, Robert F Clark, Melissa A Troester, Susan J Sumner
Breast carcinogenesis is a multistep process accompanied by widespread molecular and genomic alterations, both in tumor and in surrounding microenvironment. It is known that tumors have altered metabolism, but the metabolic changes in normal or cancer-adjacent, nonmalignant normal tissues and how these changes relate to alterations in gene expression and histological composition are not well understood. Normal or cancer-adjacent normal breast tissues from 99 women of the Normal Breast Study (NBS) were evaluated...
2018: PloS One
https://www.readbyqxmd.com/read/29664999/randomized-clinical-trial-of-the-effect-of-a-fibrin-sealant-patch-on-pancreatic-fistula-formation-after-pancreatoduodenectomy
#3
M Schindl, R Függer, P Götzinger, F Längle, M Zitt, S Stättner, P Kornprat, K Sahora, D Hlauschek, M Gnant
BACKGROUND: The potential for a fibrin sealant patch to reduce the risk of postoperative pancreatic fistula (POPF) remains uncertain. The aim of this study was to evaluate whether a fibrin sealant patch is able to reduce POPF in patients undergoing pancreatoduodenectomy with pancreatojejunostomy. METHODS: In this multicentre trial, patients undergoing pancreatoduodenectomy were randomized to receive either a fibrin patch (patch group) or no patch (control group), and stratified by gland texture, pancreatic duct size and neoadjuvant treatment...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29662534/obesity-and-outcome-of-post-menopausal-women-receiving-adjuvant-letrozole-for-breast-cancer
#4
Jamal Zekri, Kamel Farag, Ahmed Allithy
Introduction: Aromatase enzyme activity is predominant in adipose tissue. This has led to speculation that aromatase activity is elevated in obese women and subsequently decreased the clinical activity of adjuvant aromatase inhibitors (AIs) in women with estrogen receptor positive (ER+) breast cancer (BC). We investigated the effect of obesity on the outcome of this population. Patients and methods: Records of 320 consecutive post-menopausal (PM) women with ER+ BC starting single agent adjuvant letrozole between years 2005 and 2014 were retrospectively reviewed...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#5
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29644507/the-impact-of-obesity-on-breast-cancer
#6
REVIEW
Daniel F Argolo, Clifford A Hudis, Neil M Iyengar
The rates of obesity are increasing worldwide and this condition is now recognized as a leading preventable cause of cancer. Several diseases are directly related to obesity, including diabetes, hypertension, atherosclerosis, stroke, musculoskeletal disorders, and a diverse range of malignances-such as breast cancer. Obesity is associated with an increased risk of postmenopausal estrogen receptor-positive breast cancer and worse cancer-related outcomes for all breast tumor subtypes. Several mechanisms have been proposed to contribute to the obesity-cancer link, including high levels of circulating and local estrogens, altered amounts of adipokines (leptin and adiponectin), disrupted insulin/IGF signaling, modifications within the microbiome, and local and systemic effects of inflammation...
April 11, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29628981/troglitazone-inhibits-matrix-metalloproteinase-9-expression-and-invasion-of-breast-cancer-cell-through-a-peroxisome-proliferator-activated-receptor-%C3%AE-dependent-mechanism
#7
On-Yu Hong, Hyun Jo Youn, Hye-Yeon Jang, Sung Hoo Jung, Eun-Mi Noh, Hee Suk Chae, Young-Ju Jeong, Won Kim, Cheorl-Ho Kim, Jong-Suk Kim
Purpose: Peroxisome proliferator-activated receptor γ (PPARγ) is involved in the pathology of numerous diseases including atherosclerosis, diabetes, obesity, and cancer. Matrix metalloproteinases (MMPs) play a significant role in tissue remodeling related to various processes such as morphogenesis, angiogenesis, tissue repair, invasion, and metastasis. We investigated the effects of PPARγ on MMP expression and invasion in breast cancer cells. Methods: MCF-7 cells were cultured and then cell viability was monitored in an MTT assay...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29625601/connecting-the-dots-between-breast-cancer-obesity-and-alcohol-consumption-in-middle-aged-women-ecological-and-case-control-studies
#8
E R Miller, C Wilson, J Chapman, I Flight, A-M Nguyen, C Fletcher, Ij Ramsey
BACKGROUND: Breast cancer (BC) incidence in Australian women aged 45 to 64 years ('middle-aged') has tripled in the past 50 years, along with increasing alcohol consumption and obesity in middle-age women. Alcohol and obesity have been individually associated with BC but little is known about how these factors might interact. Chronic psychological stress has been associated with, but not causally linked to, BC. Here, alcohol could represent the 'missing link' - reflecting self-medication...
April 6, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29621874/psychosocial-health-of-disease-free-breast-cancer-survivors-compared-with-matched-non-cancer-controls
#9
Boyoung Park, Moo Hyun Lee, Sun-Young Kong, Eun Sook Lee
Purpose: The present study investigated the psychosocial health of disease-free breast cancer survivors who receive health examinations compared to matched non-cancer controls in a community setting. Materials and Methods: We used baseline data from the Health Examinee cohort, which is composed of subjects participating in health. The disease-free breast cancer survivors were defined as those who were ≥2 years from initial diagnosis of breast cancer who had completed treatment...
April 5, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29621383/obesity-body-composition-and-breast-cancer-an-evolving-science
#10
Elisa V Bandera, Esther M John
No abstract text is available yet for this article.
April 5, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29617707/changes-in-body-mass-index-and-physical-activity-predict-changes-in-vitality-during-a-weight-loss-trial-in-breast-cancer-survivors
#11
Kelly M Kenzik, Wendy Demark-Wahnefried, Patricia A Ganz, Graham Colditz, Cheryl L Rock, Laura Q Rogers
Background: Breast cancer survivors rank fatigue (e.g., decreased vitality) as their number one concern affecting quality of life. Excess adiposity is associated with decreased vitality in breast cancer survivors, yet weight loss intervention trials report inconsistent effects on this parameter. Methods: This is a secondary analysis of the Exercise and Nutrition to Enhance Recovery and Good Health for You trial, in which 692 overweight or obese breast cancer survivors ≤5 years from diagnosis, initiated weight loss interventions, and completed assessments semi-annually for 2 years...
March 29, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29615064/childhood-and-adolescent-phenol-and-phthalate-exposure-and-the-age-of-menarche-in-latina-girls
#12
Alexandra M Binder, Camila Corvalan, Antonia M Calafat, Xiaoyun Ye, Verónica Mericq, Ana Pereira, Karin B Michels
BACKGROUND: The age of menarche has been associated with metabolic and cardiovascular disease, as well as cancer risk. The decline in menarcheal age over the past century may be partially attributable to increased exposure to endocrine disrupting chemicals (EDCs). METHODS: We assessed the influence of 26 phenol and phthalate biomarkers on the timing of menarche in a longitudinal cohort of Chilean girls. These EDCs were quantified in urine collected prior to the onset of breast development (Tanner 1; B1), and during adolescence (Tanner 4; B4)...
April 3, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29610490/breast-cancer-obesity-tipping-the-scales-of-resistance
#13
Conor A Bradley
No abstract text is available yet for this article.
April 6, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29607324/mammographic-breast-density-and-breast-cancer-molecular-subtypes-the-kenyan-african-aspect
#14
Asim Jamal Shaikh, Maeve Mullooly, Shahin Sayed, Rose Ndumia, Innocent Abayo, James Orwa, Ronald Wasike, Zahir Moloo, Gretchen L Gierach
Introduction: Data examining mammographic breast density (MBD) among patients in Sub-Saharan Africa are sparse. We evaluated how MBD relates to breast cancer characteristics in Kenyan women undergoing diagnostic mammography. Methods: This cross-sectional study included women with pathologically confirmed breast cancers ( n = 123). Pretreatment mammograms of the unaffected breast were assessed to estimate absolute dense area (cm2 ), nondense area (cm2 ), and percent density (PD)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29599361/the-clinical-usefulness-of-the-ligasure%C3%A2-small-jaw-in-axillary-lymph-node-dissection-in-patients-with-breast-cancer
#15
Yuka Inoue, Nami Yamashita, Hiroki Ueo, Kimihiro Tanaka, Hiroshi Saeki, Eiji Oki, Eriko Tokunaga, Yoshihiko Maehara
BACKGROUND: The LigaSure™ small jaw (LS-SJ) multifunctional tissue sealing system is mainly used in cervical operations. We aimed to evaluate the clinical efficacy of the LS-SJ in axillary lymph node dissection (ALND) in comparison to the conventional method. PATIENTS AND METHODS: Ninety-two patients with breast cancer who underwent total mastectomy and ALND were included in this study. The patients were divided into the LS-SJ group (n=43) and the conventional-ALND (c-ALND) group (n=49)...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29598955/prognostic-impact-of-weight-change-during-adjuvant-chemotherapy-in-patients-with-high-risk-early-breast-cancer-results-from-the-adebar-study
#16
Nikola S Mutschler, Christoph Scholz, Thomas W P Friedl, Thomas Zwingers, Peter A Fasching, Matthias W Beckmann, Tanja Fehm, Svjetlana Mohrmann, Jessica Salmen, Carola Ziegler, Bernadette Jäger, Peter Widschwendter, Nikolaus de Gregorio, Fabienne Schochter, Sven Mahner, Nadia Harbeck, Tobias Weissenbacher, Julia Jückstock, Wolfgang Janni, Brigitte Rack
BACKGROUND: In addition to established prognostic factors, individual lifestyle-associated factors, such as obesity, physical activity, and diet, seem to modulate the course of breast cancer. The aim of this analysis was to evaluate the influence of weight changes during adjuvant chemotherapy on outcome in a large multicenter prospectively randomized trial. PATIENTS AND METHODS: The ADEBAR trial compares a sequential chemotherapy consisting of epirubicin/cyclophosphamide followed by docetaxel to an epirubicin/5-fluorouracil/cyclophosphamide regimen in patients with lymph node-positive early breast cancer...
April 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29574860/a-dietary-pattern-based-on-estrogen-metabolism-is-associated-with-breast-cancer-risk-in-a-prospective-cohort-of-postmenopausal-women
#17
Mark A Guinter, Alexander C McLain, Anwar T Merchant, Dale P Sandler, Susan E Steck
Increased exposure to estrogen is a risk factor for postmenopausal breast cancer, and dietary factors can influence estrogen metabolism. However, studies of diet and breast cancer have been inconclusive. We developed a dietary pattern associated with levels of unconjugated estradiol and the ratio of 2- and 16-hydroxylated estrogen metabolites in a subsample of Prostate, Lung, Colorectal and Ovarian Screening Trial (PLCO) participants (n=653) using reduced rank regression, and examined its association with postmenopausal breast cancer prospectively in the larger PLCO cohort (n=27,488)...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29572812/the-risk-burden-and-management-of-non-communicable-diseases-in-cerebral-palsy-a-scoping-review
#18
REVIEW
Jennifer M Ryan, Elizabeth Allen, John Gormley, Edward A Hurvitz, Mark D Peterson
AIM: To examine the risk, burden, and management of non-communicable diseases (NCDs) among people with cerebral palsy (CP). METHOD: Databases (Ovid MEDLINE, Embase Ovid, CINAHL Plus) were systematically searched up to August 2017. Data on the prevalence of risk factors for, and the burden and management of, cardiovascular diseases, diabetes, cancers, and respiratory diseases were extracted. RESULTS: Thirty-six studies that examined the prevalence of risk factors among people with CP were identified...
March 24, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29569717/the-effect-of-fasn-inhibition-on-the-growth-and-metabolism-of-a-cisplatin-resistant-ovarian-carcinoma-model
#19
Efthymia Papaevangelou, Gilberto S Almeida, Carol Box, Nandita M deSouza, Yuen-Li Chung
Overexpression of fatty acid synthase (FASN), a key regulator of the de novo synthesis of fatty acids, has been demonstrated in a variety of cancers and is associated with poor prognosis and increased multidrug resistance. Inhibition of FASN with the anti-obesity drug orlistat has been shown to have significant anti-tumorigenic effects in many cancers, notably breast and prostate. In this study, we investigated whether FASN inhibition using orlistat is an effective adjunctive treatment for ovarian cancers that have become platinum resistant using a cisplatin-resistant ovarian tumour xenograft model in mice...
March 23, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29567280/-hepatocellular-carcinoma-increase-in-incidence-or-future-plague
#20
REVIEW
Jean-Luc Raoul, Judith Raimbourg, Sandrine Hiret, Xavier Adhoute, Hélène Senellart
Hepatocellular carcinoma is the third most frequent cause of cancer death worldwide, particularly in Asia and Africa. Most cases complicate an underlying liver cirrhosis due to hepatitis B or C chronic virus infection or alcoholic abuse. But, following the current epidemics of obesity and type 2 diabetes, it appears that these diseases, associated in metabolic syndrome, are responsible for non alcoholic fatty liver disease at risk of HCC frequently before the stage of cirrhosis. Recent hypotheses consider that in the near future, cancer deaths due to HCC will overpass in USA those due to breast or colorectal cancers...
March 19, 2018: Bulletin du Cancer
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