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Obesity and breast cancer

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https://www.readbyqxmd.com/read/28634720/the-financial-impact-and-drivers-of-hospital-charges-in-contralateral-prophylactic-mastectomy-and-reconstruction-a-nationwide-inpatient-sample-hospital-analysis
#1
Alexandra Bucknor, Anmol Chattha, Klaas Ultee, Winona Wu, Parisa Kamali, Patrick Bletsis, Austin Chen, Bernard T Lee, Claire Cronin, Samuel J Lin
PURPOSE: Rates of contralateral prophylactic mastectomy (CPM) have increased over the last decade; it is important for surgeons and hospital systems to understand the economic drivers of increased costs in these patients. This study aims to identify factors affecting charges in those undergoing CPM and reconstruction. METHODS: Analysis of the Healthcare Cost and Utilization Project National Inpatient Sample was undertaken (2009-2012), identifying women aged ≥18 with unilateral breast cancer undergoing unilateral mastectomy with CPM and immediate breast reconstruction (IBR) (CPM group), in addition to unilateral mastectomy and IBR alone (UM group)...
June 20, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28633870/omega-3-free-fatty-acids-attenuate-insulin-promoted-breast-cancer-cell-proliferation
#2
Yang Guo, Sheng-Long Zhu, Yi-Kuan Wu, Zhao He, Yong-Quan Chen
High insulin levels in obese people are considered as a risk factor to induce breast carcinogenesis. And consumption of fish oils which mainly contain omega-3 fatty acids is associated with a reduced risk of breast cancer. However, whether omega-3 free fatty acids (FFAs) modulate insulin signaling pathway to prevent breast cancer is poorly understood. The current study tested the hypothesis that omega-3 FFAs attenuate insulin-induced breast cancer cell proliferation and regulate insulin signaling pathway. We show here that omega-3 FFAs attenuate MCF-7 cell proliferation and Akt and Erk1/2 phosphorylation levels stimulated by insulin...
June 2017: Nutrition Research
https://www.readbyqxmd.com/read/28630279/obesity-and-p16-ink4a-down-regulation-activate-breast-adipocytes-and-promote-their-pro-tumorigenicity
#3
Huda H Al-Khalaf, Mrad Amir, Falah Al-Mohanna, Asma Tulbah, Adher Al-Sayed, Abdelilah Aboussekhra
Obesity is increasingly recognized as a risk factor for breast cancer development. However, the molecular basis of obesity-related breast carcinogenesis remains elusive. In this study, we have shown that obesity reduces the level of the tumor suppressor p16(INK4A) protein in breast adipocytes, which showed active features and strong pro-carcinogenic potential both in vitro and in orthotopic tumor xenografts, as compared to mature adipocytes from lean women. Furthermore, obesity triggered epithelial-to-mesenchymal transition (EMT) in breast ductal epithelial cells...
June 19, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28628363/efficacy-of-a-weight-loss-intervention-for-african-american-breast-cancer-survivors
#4
Melinda Stolley, Patricia Sheean, Ben Gerber, Claudia Arroyo, Linda Schiffer, Anjishnu Banerjee, Alexis Visotcky, Giamila Fantuzzi, Desmona Strahan, Lauren Matthews, Roxanne Dakers, Cynthia Carridine-Andrews, Katya Seligman, Sparkle Springfield, Angela Odoms-Young, Susan Hong, Kent Hoskins, Virginia Kaklamani, Lisa Sharp
Purpose African American women with breast cancer have higher cancer-specific and overall mortality rates. Obesity is common among African American women and contributes to breast cancer progression and numerous chronic conditions. Weight loss interventions among breast cancer survivors positively affect weight, behavior, biomarkers, and psychosocial outcomes, yet few target African Americans. This article examines the effects of Moving Forward, a weight loss intervention for African American breast cancer survivors (AABCS) on weight, body composition, and behavior...
June 19, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28620700/gender-varying-associations-between-physical-activity-intensity-and-mental-quality-of-life-in-older-cancer-survivors
#5
David E Conroy, Kathleen Y Wolin, Cindy K Blair, Wendy Demark-Wahnefried
PURPOSE: Physical activity can enhance quality of life in cancer survivors, but this conclusion is based largely on research linking moderate-to-vigorous physical activity with quality of life. Light-intensity physical activity may be more feasible than more strenuous exercise for many older cancer survivors. This study reports a secondary analysis of baseline data from a lifestyle behavior intervention trial and examines the hypothesis that older cancer survivors who engage in more light-intensity physical activity, independent of moderate-to-vigorous activity, will report better mental quality of life...
June 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28614486/monitoring-modifiable-risk-factors-for-breast-cancer-an-obligation-for-health-professionals
#6
Verónica Guerra Guerrero, Antonieta Fazzi Baez, Carmen Gloria Cofré González, Carmen Gloria Miño González
SYNOPSIS Worldwide, breast cancer is the most common disease in women and constitutes the second leading cause of cancer death in this population. The factors that contribute to the risk of occurrence are divided into nonmodifiable and modifiable factors. Although there are interventions in primary care to prevent the disease, these measures have not produced the desired changes in women's health. This article reviews the major modifiable risk factors for breast cancer and describes how these factors can affect the incidence of cancer in women...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28612231/epsilon-aminocaproic-acid-prevents-high-glucose-and-insulin-induced-invasiveness-in-mda-mb-231-breast-cancer-cells-modulating-the-plasminogen-activator-system
#7
Rubí Viedma-Rodríguez, María Guadalupe Martínez-Hernández, Luis Antonio Flores-López, Luis Arturo Baiza-Gutman
Obesity and type II diabetes mellitus have contributed to the increase of breast cancer incidence worldwide. High glucose concentration promotes the proliferation of metastatic cells, favoring the activation of the plasminogen/plasmin system, thus contributing to tumor progression. The efficient formation of plasmin is dependent on the binding of plasminogen to the cell surface. We studied the effect of ε-aminocaproic acid (EACA), an inhibitor of the binding of plasminogen to cell surface, on proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and plasminogen activation system, in metastatic MDA-MB-231 breast cancer cells grown in a high glucose microenvironment and treated with insulin...
June 13, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28607775/obesity-and-prognostic-variables-in-colombian-breast-cancer-patients-a-cross-sectional-study
#8
Javier Cuello-López, Ana Fidalgo-Zapata, Elsa Vásquez-Trespalacios
INTRODUCTION: Obesity is an established risk factor for cancer and cancer-related deaths, including that of the breast. While the prevalence of female obesity has accelerated over the past decade in many developing countries, such as Colombia, the prevalence of overweight and obesity specifically in breast cancer populations has not been fully described. METHODS: A cross-sectional study including 849 women diagnosed with breast cancer between 2009 and 2014. Based on body mass index, prevalence of overweight (BMI ≥ 25 < 30) and obesity (BMI ≥ 30) and associations of BMI with clinical and tumor histopathological features were analyzed...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28606800/physical-exercise-positively-influences-breast-cancer-evolution
#9
REVIEW
Kalliopi Adraskela, Eleftheria Veisaki, Michael Koutsilieris, Anastassios Philippou
Breast cancer is one of the most commonly diagnosed types of cancer in women. Its pathogenesis involves genetic, hormonal, and environmental factors. A large body of evidence indicates that physical activity has positive effects on every aspect of breast cancer evolution, including prevention, medical treatment, and aftercare clinical settings. Thus, different types of exercise can influence the prevention and progression of the disease through several common mechanisms, such as reduction of insulin resistance and improvement of immunity and cardiovascular function...
May 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28601383/pretreatment-serum-concentration-of-vitamin-d-and-breast-cancer-characteristics-a-prospective-observational-mediterranean-study
#10
Giuseppe Buono, Mario Giuliano, Carmine De Angelis, Rossella Lauria, Valeria Forestieri, Matilde Pensabene, Dario Bruzzese, Sabino De Placido, Grazia Arpino
BACKGROUND: Recent studies of the correlation between breast cancer (BC) and vitamin D yielded contrasting results. Although preclinical and clinical evidence has implicated vitamin D in BC prevention and outcome, little is known about the link between vitamin D and specific BC histologically defined subtypes. In the attempt to clarify this association we correlated vitamin D levels with BC characteristics. PATIENTS AND METHODS: We enrolled 220 pre- and postmenopausal women with early BC in this prospective observational trial...
May 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28600297/the-premenopausal-breast-cancer-collaboration-a-pooling-project-of-studies-participating-in-the-national-cancer-institute-cohort-consortium
#11
Hazel B Nichols, Minouk J Schoemaker, Lauren B Wright, Craig McGowan, Mark N Brook, Kathleen M McClain, Michael E Jones, Hans-Olov Adami, Claudia Agnoli, Laura Baglietto, Leslie Bernstein, Kimberly A Bertrand, William J Blot, Marie-Christine Boutron-Ruault, Lesley Butler, Yu Chen, Michele M Doody, Laure Dossus, A Heather Eliassen, Graham G Giles, Inger T Gram, Susan E Hankinson, Judy Hoffman-Bolton, Rudolf Kaaks, Timothy J Key, Victoria A Kirsh, Cari M Kitahara, Woon-Puay Koh, Susanna C Larsson, Eiliv Lund, Huiyan Ma, Melissa A Merritt, Roger L Milne, Carmen Navarro, Kim Overvad, Kotaro Ozasa, Julie R Palmer, Petra H Peeters, Elio Riboli, Thomas E Rohan, Atsuko Sadakane, Malin Sund, Rulla M Tamimi, Antonia Trichopoulou, Lars Vatten, Kala Visvanathan, Elisabete Weiderpass, Walter C Willett, Alicja Wolk, Anne Zeleniuch-Jacquotte, Wei Zheng, Dale P Sandler, Anthony J Swerdlow
Breast cancer is a leading cancer diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence rates of advanced breast cancer have increased in recent decades for premenopausal women. Progress in identifying contributors to breast cancer risk among premenopausal women has been constrained by the limited numbers of premenopausal breast cancer cases in individual studies and resulting low statistical power to subcategorize exposures or to study specific subtypes. The Premenopausal Breast Cancer Collaborative Group was established to facilitate cohort-based analyses of risk factors for premenopausal breast cancer by pooling individual-level data from studies participating in the United States National Cancer Institute Cohort Consortium...
June 9, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28599470/the-lipid-metabolism-gene-fto-influences-breast-cancer-cell-energy-metabolism-via-the-pi3k-akt-signaling-pathway
#12
Yazhuo Liu, Ruoyu Wang, Lichuan Zhang, Jianhua Li, Keli Lou, Bingyin Shi
The present study assessed the effect of the lipid metabolism, fat mass and the obesity-associated gene (FTO), on energy metabolism of breast cancer cells. The human breast cancer cell lines, MCF-7 and MDA-MB-231, and HCC1937 human breast cells were studied. Real-time PCR was used to measure the levels of FTO mRNA from breast cancer cells and normal breast cells. MDA-MB-231 cells were transfected with miFTO inhibitor or inhibitor control, and cells were assessed for levels of lactic acid, ATP, pyruvate kinase activity, and hexokinase activity assay using specific kits...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28595943/a-role-for-g-protein-coupled-estrogen-receptor-gper-in-estrogen-induced-carcinogenesis-dysregulated-glandular-homeostasis-survival-and-metastasis
#13
REVIEW
Edward J Filardo
Mechanisms of carcinogenesis by estrogen center on its mitogenic and genotoxic potential on tumor target cells. These models suggest that estrogen receptor (ER) signaling promotes expansion of the transformed population and that subsequent accumulation of somatic mutations that drive cancer progression occur via metabolic activation of cathecol estrogens or by epigenetic mechanisms. Recent findings that GPER is linked to obesity, vascular pathology and immunosuppression, key events in the development of metabolic syndrome and intra-tissular estrogen synthesis, provides an alternate view of estrogen-induced carcinogenesis...
June 5, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28594380/effects-of-obesity-on-pro-oxidative-conditions-and-dna-damage-in-liver-of-dmba-induced-mammary-carcinogenesis-models
#14
Stepan Melnyk, Soheila Korourian, Joseph W Levy, Oleksandra Pavliv, Teresa Evans, Reza Hakkak
The prevalence of the overweight and obesity is on the rise worldwide. Obesity can increase the risk of certain cancers and liver steatosis development. Previously, we reported that obesity increased liver steatosis in a mammary tumor model, but little is known about the effects of obesity in the liver in regard to global DNA methylation, DNA damage, and oxidative/nitrosative stress. Using a mammary tumor model, we investigated the effects of obesity on oxidative stress and DNA reaction. Five-week-old lean and obese female rats were used...
June 8, 2017: Metabolites
https://www.readbyqxmd.com/read/28592099/-study-of-the-association-between-polymorphism-of-persistent-obesity-human-leptin-gene-leptin-receptor-gene-and-molecular-subtypes-of-breast-cancer
#15
X L Yuan, Z P Xu, C R Liu, L P Yan, P Tao, P Xiong, Q Li, M Zhou, H Li, M Zhao, J Y Li
Objectives: To explore the association between the polymorphism of persistent obesity and genetic variations in the LEP (human leptin gene, LEP) and LEPR (leptin receptor gene, LEPR) genes and different molecular subtypes of breast cancer. Methods: All 703 female patients of breast cancer diagnosed by histopathology in the Sichuan Cancer Hospital or the West China Hospital, excluding patients with metastatic breast cancer or mental disease, were selected as cases from April 2014 to May 2015. At the same time, 805 healthy women received physical examination in medical examination center of Sichuan People Hospital or Shuangliu maternal and child health care hospital, excluding those with therioma, breast disease, and mental disease, were enrolled in control group...
June 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28591216/modification-effects-of-genetic-polymorphisms-in-fto-il-6-and-hspd1-on-the-associations-of-diabetes-with-breast-cancer-risk-and-survival
#16
Rui-Mei Zhu, Wei Lin, Wei Zhang, Jun-Ting Ren, Yi Su, Jian-Rong He, Ying Lin, Feng-Xi Su, Xiao-Ming Xie, Lu-Ying Tang, Ze-Fang Ren
The contribution of diabetes to breast cancer remains uncertain among Chinese females, which may result from different genetic factors. We evaluated the associations of diabetes, combined with the polymorphisms in the genes of fat mass and obesity-associated gene (FTO), interleukin 6 (IL-6), and heat shock protein 60 (HSPD1), with breast cancer risk and survival in a Chinese Han population. The information on the history of diabetes was collected from 1551 incident breast cancer cases and 1605 age-frequency matched controls in Guangzhou, China...
2017: PloS One
https://www.readbyqxmd.com/read/28585217/obesity-associated-breast-cancer-analysis-of-risk-factors
#17
Atilla Engin
Several studies show that a significantly stronger association is obvious between increased body mass index (BMI) and higher breast cancer incidence. Furthermore, obese women are at higher risk of all-cause and breast cancer specific mortality when compared to non-obese women with breast cancer. In this context, increased levels of estrogens due to excessive aromatization activity of the adipose tissue, overexpression of pro-inflammatory cytokines, insulin resistance, hyperactivation of insulin-like growth factors (IGFs) pathways, adipocyte-derived adipokines, hypercholesterolemia and excessive oxidative stress contribute to the development of breast cancer in obese women...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28579830/effect-of-reduced-dietary-fat-on-estradiol-adiponectin-and-igf-1-levels-in-postmenopausal-women-with-breast-cancer
#18
Blanca Murillo-Ortiz, Sandra Martínez-Garza, Vanessa Cárdenas Landeros, Gerardo Cano Velázquez, David Suárez García
INTRODUCTION: In recent years, epidemiological studies have strongly related obesity with an increased risk of developing postmenopausal breast cancer. The aromatization of fatty tissue increases the levels of estradiol and adiponectin, which is correlated with the body mass index (BMI). It is of interest to investigate the effect of reducing BMI on estradiol, adiponectin, and IGF-1, as reducing BMI could be a new strategy to limit the risk of recurrence during the adjuvant treatment of breast cancer...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28574847/body-mass-index-and-persistent-pain-after-breast-cancer-surgery-findings-from-the-women-s-healthy-eating-and-living-study-and-a-meta-analysis
#19
Yuan-Yuan Ding, Peng Yao, Lang Wu, Zhen-Kai Han, Tao Hong, Yong-Qiang Zhu, Hong-Xi Li
The purpose of this study is to evaluate the association between body mass index (BMI) and persistent pain after breast cancer surgery in a prospective study and synthesize available evidence through a meta-analysis. In the Women's Healthy Eating and Living (WHEL) Study, 3,088 women diagnosed of breast cancer were enrolled and assessed. After 4 years, a subgroup of 2,131 women was re-assessed for the pain information. Logistic regression models were used to assess the associations of baseline BMI and BMI change between baseline and 4 years of follow-up with general pain symptoms at 4 years of follow-up...
May 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28573159/high-fat-diet-induced-breast-cancer-model-in-rat
#20
Meng-Ju Wu, Chun-Ju Chang
Obesity has been linked to breast cancer progression but the underlying mechanisms remain obscure. Being overweight or obese for a woman at the time she is diagnosed with breast cancer is linked to a high risk of recurrence regardless of treatment factors. In rodents, high body weight is also associated with increased incidence of spontaneous and chemically induced tumors. To study the complex interaction between the mammary epithelia and the microenvironment, with a focus on the mechanism underlying the role obesity plays in the regulation of the cancer stem cell traits and the development of mammary cancer in vivo, we have established a diet-induced obesity (DIO) rat model of breast cancer (Chang et al...
July 5, 2016: Bio-protocol
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