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Obesity and breast cancer

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https://www.readbyqxmd.com/read/28416368/nutritional-management-in-women-with-polycystic-ovary-syndrome-a-review-study
#1
REVIEW
Zeinab Faghfoori, Siavash Fazelian, Mahdi Shadnoush, Reza Goodarzi
Polycystic ovary syndrome (PCOS) is endocrine disorder in women of reproductive age, which leads to reproductive, hormonal and metabolic abnormalities. Due to the presence of insulin resistance, PCOS increases the risk of chronic diseases like type 2 diabetes, hypertension, lipid disorders, cardiovascular diseases and malignancies such as breast and endometrial cancer. The actual cause of this syndrome is unknown but environmental factors such as dietary habits play an important role in prevention and treatment and lifestyle modifications are the most important therapeutic strategies in these patients...
April 5, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28416193/lep-rs7799039-lepr-rs1137101-and-adipoq-rs2241766-and-1501299-polymorphisms-are-associated-with-obesity-and-chemotherapy-response-in-mexican-women-with-breast-cancer
#2
Alejandra Méndez-Hernández, Martha Patricia Gallegos-Arreola, Hortensia Moreno-Macías, Jorge Espinosa Fematt, Rebeca Pérez-Morales
BACKGROUND: Obesity plays a major role in the pathogenesis of breast cancer. Leptin (LEP) and adiponectin (ADIPOQ) are important in the regulation of adipose tissue. The response to cancer treatment depends on the histological and molecular tumor type, clinical stage, and genetic variability that might promote carcinogenic development. The aim of this study was to investigate the association between overweight/obesity and polymorphisms in the LEP (rs7799039), LEP receptor (LEPR; rs1137101), and ADIPOQ genes (rs2241766, rs1501299) with the response to breast cancer treatment in Mexican women...
March 22, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28415622/is-fto-gene-variant-related-to-cancer-risk-independently-of-adiposity-an-updated-meta-analysis-of-129-467-cases-and-290-633-controls
#3
Yu Kang, Fang Liu, Yao Liu
Previous studies have examined the association between the fat mass and obesity-associated (FTO) gene variant and risk of cancer in diverse populations. However, the results have been inconsistent. PubMed and Embase databases were searched for the eligible publications in English language by July, 2016. The associations of FTO variants with cancer risk were estimated by calculating the pooled odds ratios and 95% confidence intervals by meta-analyses. A total of 27 publications (129,467 cancer cases and 290,633 normal controls) were included in our meta-analysis...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414093/imbalance-in-leptin-adiponectin-levels-and-leptin-receptor-expression-as-chief-contributors-to-triple-negative-breast-cancer-progression-in-northeast-india
#4
Rizwana Sultana, Amal Ch Kataki, Bibhuti Bhusan Borthakur, Tarun K Basumatary, Sujoy Bose
BACKGROUND: Triple-Negative breast cancer (TNBC), accounts for a large percentage of breast cancer cases in India including Northeast India. TNBC has an unclear molecular aetiology and hence limited targeted therapies. Human breast is comprised of glandular, ductal, connective, and adipose tissues. Adipose tissue is composed of adipocytes. The adipocytes apart from being energy storage depots, are also active sources of adipocytokines and/or adipokines. The role of adipokines in breast cancer including TNBC has been sporadically documented...
April 14, 2017: Gene
https://www.readbyqxmd.com/read/28410181/alcohol-intake-among-breast-cancer-survivors-change-in-alcohol-use-during-a-weight-management-intervention
#5
Tera L Fazzino, Kimberly Fleming, Christie Befort
BACKGROUND: Daily alcohol intake in quantities as small as half a drink/day significantly increases the risk of breast cancer recurrence for postmenopausal survivors. Interventions designed to modify alcohol use among survivors have not been studied; however, lifestyle interventions that target change in dietary intake may affect alcohol intake. OBJECTIVE: To evaluate change in alcohol use during a weight loss intervention for obese, rural-dwelling breast cancer survivors...
November 9, 2016: JMIR Cancer
https://www.readbyqxmd.com/read/28408965/phospholipase-c-related-catalytically-inactive-protein-can-regulate-obesity-a-state-of-peripheral-inflammation
#6
REVIEW
Yosuke Yamawaki, Kana Oue, Satomi Shirawachi, Satoshi Asano, Kae Harada, Takashi Kanematsu
Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with chronic neuropathologic conditions such as depression and Alzheimer's disease. However, there is strong evidence that weight loss reduces these risks, by limiting blood pressure and improving levels of serum triglycerides, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol...
February 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28408379/-obesity-associated-breast-cancer-in-lean-women-metabolism-and-inflammation-as-critical-modifiers-of-risk
#7
EDITORIAL
Gerald V Denis, Julie R Palmer
Why is obesity only weakly associated with certain "obesity-driven" cancers? Recent population studies identify cohorts of high body mass index (BMI) subjects with unexpectedly reduced risk for breast and colon cancer, and normal BMI subjects with unexpectedly elevated risk for breast cancer, provoking hard thinking about cellular and molecular mechanisms that most strongly couple obesity to cancer occurrence or progression. Emerging work suggests that abnormal metabolism and its associated chronic inflammation make the difference...
April 13, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28402277/the-influence-of-tumor-necrosis-factor-%C3%AE-on-the-tumorigenic-wnt-signaling-pathway-in-human-mammary-tissue-from-obese-women
#8
Agathe Roubert, Kelly Gregory, Yuyang Li, Anna C Pfalzer, Jinchao Li, Sallie S Schneider, Richard J Wood, Zhenhua Liu
Epidemiological studies have convincingly suggested that obesity is an important risk factor for postmenopausal breast cancer, but the mechanisms responsible for this relationship are still not fully understood. We hypothesize that obesity creates a low-grade inflammatory microenvironment, which stimulates Wnt-signaling and thereby promotes the development of breast cancer. To test this hypothesis, we evaluated the correlations between expression of multiple inflammatory cytokines and Wnt pathway downstream genes in mammary tissues from women (age ≥ 50) undergoing reduction mammoplasty...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28401024/inhibition-of-stat3-signaling-blocks-obesity-induced-mammary-hyperplasia-in-a-mouse-model
#9
Jeong Won Park, Li Zhao, Mark C Willingham, Sheue-Yann Cheng
Compelling epidemiologic evidence indicates that obesity is a risk factor for human cancers, including breast. However, molecular mechanisms by which obesity could contribute to the development of breast cancer remain unclear. To understand the impact of obesity on breast cancer development, we used a mutant mouse that expresses a mutated thyroid hormone receptor β (denoted as PV) with haplodeficiency of the Pten gene (Thrb(PV/PV)Pten(+/-) mice). We previously showed that adult nulliparous female Thrb(PV/PV)Pten(+/-) mice developed extensive mammary hyperplasia and breast tumors...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28401013/resistin-confers-resistance-to-doxorubicin-induced-apoptosis-in-human-breast-cancer-cells-through-autophagy-induction
#10
Zhenyu Liu, Aiping Shi, Dong Song, Bing Han, Zhiru Zhang, Le Ma, Dongxu Liu, Zhimin Fan
Clear evidence has linked obesity to a high risk of incidence as well as poor clinical outcome of breast cancer. It has been proven that changes in the levels of adipokines caused by obesity are associated with the initiation and progression of breast cancer. Resistin is a novel adipokine that is upregulated in breast cancer patients and promotes breast cancer cell growth, invasion, and migration. The aim of the study was to investigate whether resistin affected the efficacy of doxorubicin (Dox), one of the most effective anthracycline chemotherapeutic agents in the treatment of breast cancer...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28395233/the-effect-of-obesity-on-pathological-complete-response-and-survival-in-breast-cancer-patients-receiving-uncapped-doses-of-neoadjuvant-anthracycline-taxane-based-chemotherapy
#11
Alex Farr, Myriam Stolz, Lukas Baumann, Zsuzsanna Bago-Horvath, Elisabeth Oppolzer, Georg Pfeiler, Michael Seifert, Christian F Singer
PURPOSE: The effect of obesity in breast cancer patients undergoing neoadjuvant chemotherapy (NAC) remains controversial. The aim of this study was to determine the obesity-related effect on pathological complete response (pCR) and survival in women receiving full uncapped doses of NAC. METHODS: We retrospectively analyzed the data of all consecutive women who underwent anthracycline-taxane-based NAC for primary breast cancer between 2005 and 2015 at the Department of Obstetrics and Gynecology, Medical University of Vienna...
April 7, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28392934/evaluation-of-a-web-based-weight-loss-intervention-in-overweight-cancer-survivors-aged-50%C3%A2-years-and-younger
#12
S M Lynch, C T Stricker, J C Brown, J M Berardi, D Vaughn, S Domchek, S Filseth, A Branas, E Weiss-Trainor, K H Schmitz, D B Sarwer
PURPOSE: Half of adult cancer survivors under age 50 years are obese. Excess body weight is associated with cancer recurrence, and effective weight loss interventions for younger cancer survivors are needed. Commercially available, online weight loss programmes are readily accessible, but few have been studied in this population. This study employed a single-arm, pre-post intervention (baseline-6 month/baseline-12 month comparisons) to preliminarily explore feasibility, efficacy and safety of an online, commercially available weight loss programme in breast (n = 30) and testicular (n = 16) cancer survivors under age 50 years...
March 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/28389043/interventions-to-reduce-the-risk-of-ovarian-and-fallopian-tube-cancer-a-european-menopause-and-andropause-society-postition-statement
#13
REVIEW
Faustino R Pérez-López, Iuliana Ceausu, Herman Depypere, Sean Kehoe, Irene Lambrinoudaki, Alfred Mueck, Levent M Senturk, Tommaso Simoncini, John C Stevenson, Petra Stute, Margaret Rees
BACKGROUND: Ovarian cancer is a leading cause of female gynecological cancer-related death, and there are no effective screening procedures or early diagnostic approaches. AIMS: To examine risk factors and risk-reducing strategies for both sporadic and familial tumors. MATERIALS AND METHODS: Literature review and consensus of expert opinion. RESULTS AND CONCLUSIONS: In women with a genetic predisposition to ovarian cancer, salpingo-oophorectomy reduces the risk of ovarian malignancy, and to a lesser degree of breast cancer...
March 15, 2017: Maturitas
https://www.readbyqxmd.com/read/28382922/laser-direct-write-based-fabrication-of-a-spatially-defined-biomimetic-construct-as-a-potential-model-for-breast-cancer-cell-invasion-into-adipose-tissue
#14
Benjamin Tyler Vinson, Theresa Phamduy, Josh Shipman, Brian Riggs, Amy Strong, Walter Murfee, Matthew Burow, Bruce Bunnell, Samuel Sklare, Yong Huang, Douglas Chrisey
Epithelial-adipose interaction is an integral step in breast cancer cell invasion and progression towards lethal metastatic disease.  Understanding the physiological contribution of obesity, a major contributor to breast cancer risk and negative prognosis in post-menopausal patients, on cancer cell invasion requires detailed co-culture constructs that reflect mammary microarchitecture.  Using laser direct-write, a laser-based CAD/CAM bioprinting technique, we have demonstrated the ability to construct breast cancer cell-laden hydrogel microbeads into spatially defined patterns in hydrogel matrices containing differentiated adipocytes...
April 6, 2017: Biofabrication
https://www.readbyqxmd.com/read/28381227/social-determinants-of-breast-cancer-in-the-caribbean-a-systematic-review
#15
REVIEW
Catherine R Brown, Ian R Hambleton, Shawn M Hercules, Miriam Alvarado, Nigel Unwin, Madhuvanti M Murphy, E Nigel Harris, Rainford Wilks, Marlene MacLeish, Louis Sullivan, Natasha Sobers-Grannum
BACKGROUND: Breast cancer is the leading cause of cancer deaths among women in the Caribbean and accounts for >1 million disability adjusted life years. Little is known about the social inequalities of this disease in the Caribbean. In support of the Rio Political Declaration on addressing health inequities, this article presents a systematic review of evidence on the distribution, by social determinants, of breast cancer risk factors, frequency, and adverse outcomes in Caribbean women...
April 5, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28376727/glucose-and-lipoprotein-biomarkers-and-breast-cancer-severity-using-data-from-the-swedish-amoris-cohort
#16
Jennifer C Melvin, Hans Garmo, Lars Holmberg, Niklas Hammar, Göran Walldius, Ingmar Jungner, Mats Lambe, Mieke Van Hemelrijck
BACKGROUND: The lipid and glucose metabolisms are postulated as possible intermediary mechanisms in linking obesity and breast cancer (BC). Links between serum lipid and glucose biomarkers and BC risk has been observed in the Swedish Apolipoprotein MORtality RISk (AMORIS) cohort. We conducted a follow-up analysis including information on tumour characteristics. METHODS: One thousand eight hundred twenty-four women diagnosed with BC, with serum biomarker levels of glucose, triglycerides, cholesterol (total, HDL, and LDL), and apolipoproteins A-1 and B recorded in a routine health check at baseline were included...
April 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28376218/bmi-lifestyle-factors-and-taxane-induced-neuropathy-in-breast-cancer-patients-the-pathways-study
#17
Heather Greenlee, Dawn L Hershman, Zaixing Shi, Marilyn L Kwan, Isaac J Ergas, Janise M Roh, Lawrence H Kushi
Lifestyle factors may be associated with chemotherapy-induced peripheral neuropathy (CIPN). We examined associations between body mass index (BMI) and lifestyle factors with CIPN in the Pathways Study, a prospective cohort of women with invasive breast cancer. Methods: Analyses included 1237 women who received taxane treatment and provided data on neurotoxicity symptoms. Baseline interviews assessed BMI (normal: <25 kg/m 2 ; overweight: 25-29.9 kg/m 2 ; obese: ≥30 kg/m 2 ), moderate-to-vigorous physical activity (MVPA) (low: <2...
February 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28373404/precancer-atlas-to-drive-precision-prevention-trials
#18
Avrum Spira, Matthew B Yurgelun, Ludmil Alexandrov, Anjana Rao, Rafael Bejar, Kornelia Polyak, Marios Giannakis, Ali Shilatifard, Olivera J Finn, Madhav Dhodapkar, Neil E Kay, Esteban Braggio, Eduardo Vilar, Sarah A Mazzilli, Timothy R Rebbeck, Judy E Garber, Victor E Velculescu, Mary L Disis, Douglas C Wallace, Scott M Lippman
Cancer development is a complex process driven by inherited and acquired molecular and cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality will take a fundamental rethinking and deep understanding of premalignant biology. In this Perspective, we propose a national concerted effort to create a Precancer Atlas (PCA), integrating multi-omics and immunity - basic tenets of the neoplastic process. The biology of neoplasia caused by germline mutations has led to paradigm-changing precision prevention efforts, including: tumor testing for mismatch repair (MMR) deficiency in Lynch syndrome establishing a new paradigm, combinatorial chemoprevention efficacy in familial adenomatous polyposis (FAP), signal of benefit from imaging-based early detection research in high-germline risk for pancreatic neoplasia, elucidating early ontogeny in BRCA1-mutation carriers leading to an international breast cancer prevention trial, and insights into the intricate germline-somatic-immunity interaction landscape...
April 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28373182/energy-balance-modulation-impacts-epigenetic-reprogramming-er%C3%AE-and-er%C3%AE-expression-and-mammary-tumor-development-in-mmtv-neu-transgenic-mice
#19
Emily L Rossi, Sarah M Dunlap, Laura W Bowers, Subreen A Khatib, Steven S Doerstling, Laura A Smith, Manu A Sharma, Darcy Holley, Powel H Brown, Marcos R Estecio, Donna F Kusewitt, Linda A deGraffenried, Scott J Bultman, Stephen D Hursting
The association between obesity and breast cancer risk and prognosis is well established in ER-positive disease but less clear in HER2-positive disease. Here, we report preclinical evidence suggesting weight maintenance through calorie restriction may limit risk of HER2-positive breast cancer. In female MMTV-HER2/neu transgenic mice, we found that ERα and ERβ expression, mammary tumorigenesis and survival are energy balance-dependent in association with epigenetic reprogramming. Mice were randomized to receive a calorie restriction (CR), overweight (OW)-inducing, or diet-induced obesity (DIO) regimen (n = 27/group)...
April 3, 2017: Cancer Research
https://www.readbyqxmd.com/read/28370954/citrus-flavonoid-naringenin-reduces-mammary-tumor-cell-viability-adipose-mass-and-adipose-inflammation-in-obese-ovariectomized-mice
#20
Jia-Yu Ke, Taylor Banh, Yung-Hsuan Hsiao, Rachel M Cole, Shana R Straka, Lisa D Yee, Martha A Belury
SCOPE: Obesity-related metabolic dysregulation may be a link between obesity and postmenopausal breast cancer. Naringenin, a flavonoid abundant in grapefruits, displays beneficial effects on metabolic health and tumorigenesis. Here, we assessed the effects of naringenin on mammary tumor cell growth in vitro and in obese ovariectomized mice. METHODS AND RESULTS: Naringenin inhibited cell growth, increased phosphorylation of AMP-activated protein kinase (AMPK), down-regulated CyclinD1 expression, and induced cell death in E0771 mammary tumor cells...
March 30, 2017: Molecular Nutrition & Food Research
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