Jesus Avila, Juan S Jiménez, Carmen L Sayas, Marta Bolós, Juan C Zabala, Germán Rivas, Felix Hernández
Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary, and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers, and larger polymers in physiological and pathological situations.
2016: Frontiers in Aging Neuroscience