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https://www.readbyqxmd.com/read/28646772/prevalence-of-immune-related-systemic-adverse-events-in%C3%A2-patients-treated-with-anti-programmed-cell-death-1-anti-programmed-cell-death-ligand-1-agents-a-single-centre-pharmacovigilance-database-analysis
#1
Sébastien Le Burel, Stéphane Champiat, Christine Mateus, Aurélien Marabelle, Jean-Marie Michot, Caroline Robert, Rakiba Belkhir, Jean-Charles Soria, Salim Laghouati, Anne-Laure Voisin, Olivier Fain, Arsène Mékinian, Laetitia Coutte, Tali-Anne Szwebel, Laetitia Dunogeant, Bertrand Lioger, Cécile Luxembourger, Xavier Mariette, Olivier Lambotte
AIM: The growing use of immune checkpoint inhibitors (ICIs) is associated with the occurrence of immune-related adverse events (irAEs). Few data are published on systemic, immunohaematological and rheumatic irAEs. In a pharmacovigilance database analysis, we screened for these irAEs and calculated their prevalence. PATIENTS AND METHODS: Participants were recruited via Registre des Effets Indésirables Sévères des Anticorps Monoclonaux Immunomodulateurs en Cancérologie (REISAMIC)(1) a French registry of grade ≥2 irAEs occurring in ICI-treated patients...
June 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28643486/comparison-of-intact-pth-and-bio-intact-pth-assays-among-non-dialysis-dependent-chronic-kidney-disease-patients
#2
Yael Einbinder, Sydney Benchetrit, Eliezer Golan, Tali Zitman-Gal
BACKGROUND: The third-generation bio-intact parathyroid hormone (PTH) (1-84) assay was designed to overcome problems associated with the detection of C-terminal fragments by the second-generation intact PTH assay. The two assays have been compared primarily among dialysis populations. The present study evaluated the correlations and differences between these two PTH assays among patients with chronic kidney disease (CKD) stages 3 to 5 not yet on dialysis. METHODS: Blood samples were collected from 98 patients with CKD stages 3 to 5...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28641599/association-between-level-of-exposure-to-death-and-dying-and-professional-quality-of-life-among-palliative-care-workers
#3
Tali Samson, Pesach Shvartzman
BACKGROUND: Exposure to the death and dying of others is an anxiety-provoking condition that can contribute to psychological stress. However, the results of empirical studies that evaluated work-related outcomes among physicians and nurses with repeated exposure to dying patients are not consistent. OBJECTIVE: Our aim was to evaluate whether a high level of exposure to death and dying (LED) can increase the risk for poor professional quality of life (ProQoL) in most healthcare workers, but it can also improve ProQoL in a subset of healthcare workers with specific characteristics...
June 23, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28635542/gene-expression-study-of-mitochondrial-complex-i-in-schizophrenia-and-paranoid-personality-disorder
#4
Arvin Haghighatfard, Sarah Andalib, Mozhdeh Amini Faskhodi, Soha Sadeghi, Amir Hossein Ghaderi, Shadi Moradkhani, Jalal Rostampour, Zeinab Tabrizi, Ali Mahmoodi, Talie Karimi, Zakieh Ghadimi
OBJECTIVES: The aetiology and molecular mechanisms of schizophrenia (SCZ) and paranoid personality disorder (PPD) are not yet clarified. The present study aimed to assess the role of mitochondrial complex I and cell bioenergetic pathways in the aetiology and characteristics of SCZ and PPD. METHODS: mRNA levels of all genomic and mitochondrial genes which encode mitochondrial complex I subunits (44 genes) were assessed in blood in 634 SCZ, 340 PPD patients and 528 non-psychiatric subjects using quantitative real-time PCR, and associated comprehensive psychiatric, neurological and biochemical assessments...
February 20, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28633993/microfluidics-as-a-strategic-player-to-decipher-single-cell-omics
#5
REVIEW
Ouriel Caen, Heng Lu, Philippe Nizard, Valerie Taly
Most cell studies are performed at a population level, relying on the assumption of a normal distribution of the function and fate of a cell among a population. However, technologies allowing single-cell analysis (SCA) have recently arisen and have led to increasing evidence of cell population heterogeneity and its importance. Tremendous amounts of new data could now be uncovered to redefine our understanding of cell omics. Microfluidics has emerged as a major technological player in this new era and is gradually increasing in use among biology laboratories, mainly due to the single-cell high-throughput handling solutions it offers...
June 17, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28632968/perspective-on-precision-medicine-in-oncology
#6
Tali M Johnson
The topic of precision medicine is increasingly more prevalent in the general medical literature with oncology research leading the way. Many factors, such as, availability of targeted drugs, advances in laboratory science, and improved information systems, converged to make precision medicine research possible on a large scale at the National Cancer Institute. The resultant big data will spur new kinds of research in the decades to come, but until then, all clinicians are challenged to make sense of an overabundance of information when managing individual patients...
June 20, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28630842/irreducible-subtalar-dislocation-caused-by-sustentaculum-tali-incarceration
#7
Mourad Zaraa, Ismail Jerbi, Sabri Mahjoub, Heithem Sehli, Mondher Mbarek
INTRODUCTION: Subtalar dislocation is an uncommon lesion in traumatology chiefly when it concerns the lateral form. Surgical treatment is required when a fracture is related or the dislocation is irreducible. Even well treated, these dislocations progress unavoidably to subtalar arthrosis, which stays well tolerated. CASE REPORT: A 46-year-old male with irreducible lateral subtalar dislocation caused sustentaculum tali incarceration confirmed on computed tomography (CT)...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28622598/utilization-of-geant-to-calculation-of-production-yield-for-89-zr-by-charge-particles-interaction-on-89-y-nat-zr-and-nat-sr
#8
Mozhgan Sharifian, Mahdi Sadeghi, Behrouz Alirezapour
The (89)Zr, is one of the radionuclide with near-ideal properties for PET due to its suitable half-life and decay properties. The cross-section of (89)Zr via (89)Y(p,n)(89)Zr, (89)Y(d,2n)(89)Zr, (nat)Sr(α,xn)(89)Zr and (nat)Zr(p,pxn)(89)Zr, were calculated by the TALYS-1.8 code to predict the optimum range of charge particle energy. The Monte Carlo code GEANT4 was used to simulate the formation of (89)Zr in the target body. The simulated (89)Zr yield was in good agreement with published experimental results in the optimum energy range...
June 9, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28612702/genetic-variability-and-population-structure-of-the-new-world-begomovirus-euphorbia-yellow-mosaic-virus
#9
Talita Bernardon Mar, César Augusto Diniz Xavier, Alison Talis Martins Lima, Angélica Maria Nogueira, José Cleydson Ferreira Silva, Roberto Ramos-Sobrinho, Douglas Lau, F Murilo Zerbini
The emergence of begomoviruses (whitefly-transmitted viruses classified in the genus Begomovirus, family Geminiviridae) in Brazil probably occurred by horizontal transfer from non-cultivated plants after the introduction of Bemisia tabaci MEAM1. The centre of diversity of Euphorbia heterophylla (Euphorbiaceae) is located in Brazil and Paraguay, where it is an invasive species in soybean and other crops. Reports of possible begomovirus infection of E. heterophylla in Brazil date back to the 1950s. In 2011, Euphorbia yellow mosaic virus (EuYMV) was described in symptomatic plants collected in the Brazilian state of Goiás...
June 13, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28603281/peripheral-maternal-leukocytes-are-activated-in-response-to-cytokines-secreted-by-uterine-tissues-of-pregnant-women
#10
Tali Farine, Stephen Lye, Oksana Shynlova
No abstract text is available yet for this article.
June 12, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28599227/assessment-and-estimation-of-67-cu-production-yield-via-deuteron-induced-reactions-on-nat-zn-and-70-zn
#11
Seyedeh Fatemeh Hosseini, Mohammadreza Aboudzadeh, Mahdi Sadeghi, Ahmad Ahmadi Teymourlouy, Malihe Rostampour
(67)Cu radioisotope is a beta particle-emitting nuclide used in radioimmunotherapy (RIT) as well as for imaging, tracer kinetic studies and dosimetry. (67)Cu can be produced by bombarding (nat)Zn with deuterons. In this study, the physical yields of (67)Cu via (nat)Zn(d,x)(67)Cu reaction channel as well as via subreactions of (68)Zn(d,2pn)(67)Cu, (67)Zn(d,2p)(67)Cu, (70)Zn(d,2p3n)(67)Cu, (68)Zn(d,x)(67)Ni(T1/2=21s)→(67)Cu and (70)Zn(d,x)(67)Ni(T1/2=21s)→(67)Cu in the (nat)Zn target have been calculated by using the MCNPX-2...
May 31, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28595551/nmr-based-drug-development-and-improvement-against-malignant-melanoma-implications-for-the-mia-protein-family
#12
Oliver Arnolds, Xueyin Zhong, King Tuo Yip, Miriam Schöpel, Bastian Kohl, Stefanie Pütz, Raid Abdel-Jalil, Raphael Stoll
The Melanoma Inhibitory Activity (MIA) protein is strongly expressed and secreted by malignant melanoma cells and was shown to promote melanoma development and invasion. The MIA protein was the first extracellular protein shown to adopt a Src homology 3 (SH3) domain-like fold in solution that can bind to fibronectin type III domains. Together with MIA, the homologous proteins OTOR (or FDP), MIA-2, and TANGO (or MIA-3) constitute a protein family of non-cytoplasmic and - except for full-length TANGO and TANGO1-like (TALI) - extracellular SH3-domain containing proteins...
June 8, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28591632/bread-affects-clinical-parameters-and-induces-gut-microbiome-associated-personal-glycemic-responses
#13
Tal Korem, David Zeevi, Niv Zmora, Omer Weissbrod, Noam Bar, Maya Lotan-Pompan, Tali Avnit-Sagi, Noa Kosower, Gal Malka, Michal Rein, Jotham Suez, Ben Z Goldberg, Adina Weinberger, Avraham A Levy, Eran Elinav, Eran Segal
Bread is consumed daily by billions of people, yet evidence regarding its clinical effects is contradicting. Here, we performed a randomized crossover trial of two 1-week-long dietary interventions comprising consumption of either traditionally made sourdough-leavened whole-grain bread or industrially made white bread. We found no significant differential effects of bread type on multiple clinical parameters. The gut microbiota composition remained person specific throughout this trial and was generally resilient to the intervention...
June 6, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28583609/global-hemostasis-in-healthy-bitches-during-pregnancy-and-at-different-estrous-cycle-stages-evaluation-of-routine-hemostatic-tests-and-thromboelastometry
#14
Sigal Klainbart, Alexandra Slon, Efrat Kelmer, Tali Bdolah-Abram, Tal Raz, Gilad Segev, Itamar Aroch, Smadar Tal
This study assessed the global hemostasis (including prothrombin time [PT], activated partial thromboplastin time [aPTT], antithrombin activity [ATA], fibrinogen and d-Dimer concentrations, platelet count, plateletcrit and thromboelastometry) in healthy pregnant bitches, comparing the results with those of healthy bitches at different estrous cycle stages, and assessed whether hemostatic changes during pregnancy are associated with serum progesterone concentration or the presence of fetuses in utero. The results show that pregnant bitches have higher fibrinogen concentration, platelet count and platelatecrit, and that fibrin and global clot formations occur faster than in non-pregnant bitches at different estrous cycle stages...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28583445/novel-concepts-of-prevention-and-treatment-of-atopic-dermatitis-through-barrier-and-immune-manipulations-with-implications-for-the-atopic-march
#15
REVIEW
Tali Czarnowicki, James G Krueger, Emma Guttman-Yassky
Skin barrier abnormalities have been suggested to play an essential role in initiation of early atopic dermatitis (AD). Antigen penetration through a compromised barrier likely leads to increased innate immune responses, antigen-presenting cell stimulation, and priming of overt cutaneous disease. In a TH2-promoting environment, T-cell/B-cell interactions occurring in regional lymph nodes lead to excessive IgE switch. Concurrent redistribution of memory T cells into the circulation not only leads to exacerbation of AD through T-cell skin infiltration but also spreads beyond the skin to initiate the atopic march, which includes food allergy, asthma, and allergic rhinitis...
June 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28578800/geometric-analysis-of-the-talus-and-development-of-a-generic-talar-prosthetic
#16
Alexandra Trovato, Marwan El-Rich, Samer Adeeb, Suki Dhillon, Nadr Jomha
BACKGROUND: Trauma to the talus can result in fracture, avascular necrosis and structural collapse. Treatment has been limited to surgical fusion and total ankle arthroplasty. Total ankle arthroplasty may not be an appropriate treatment for avascular necrosis while surgical fusion of the joint limits mobility. Custom-made implants have recently been used to address these limitations but have lengthy delays between injury and surgery and higher associated costs. A generic talar prosthesis available in various sizes may serve as a suitable alternative...
June 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28577801/an-update-on-the-pathophysiology-of-atopic-dermatitis
#17
REVIEW
Kunal Malik, Kerry D Heitmiller, Tali Czarnowicki
Atopic dermatitis (AD) is increasingly recognized as a complex, inflammatory skin disease involving interplay of multiple elements. This article notes key advances in understanding of immune dysregulation, skin barrier dysfunction, environmental, genetic, and microbial influences orchestrating disease pathogenesis, and the relevance of therapeutic interventions in each area. Accumulating evidence and the discovery of new T-cell subsets has matured AD as a multiple-cytokine-axes-driven disorder, evolved from the widely held belief of it being a biphasic Th1/Th2 disease...
July 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28576867/early-evaluation-of-circulating-tumor-dna-as-marker-of-therapeutic-efficacy-in-metastatic-colorectal-cancer-patients-placol-study
#18
Fanny Garlan, Pierre Laurent-Puig, David Sefrioui, Nathalie Siauve, Audrey Didelot, Nasrin Sarafan-Vasseur, Pierre Michel, Geraldine Perkins, Claire Mulot, Hélène Blons, Julien Taieb, Frederic Di Fiore, Valerie Taly, Aziz Zaanan
Purpose. Markers of chemotherapy efficacy in metastatic colorectal cancer (mCRC) are essential for optimization of treatment strategies. We evaluated the applicability of early changes in circulating tumor DNA (ctDNA) as a marker of therapeutic efficacy. <p>Experimental design. This prospective study enrolled consecutive mCRC patients receiving a first- or second-line chemotherapy. CtDNA was assessed in plasma collected before the first (C0), second (C1) and/or third (C2) chemotherapy cycle, using picodroplet-digital PCR assays based either on detection of gene mutation (KRAS, BRAF, TP53) or hypermethylation (WIF1, NPY)...
June 2, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28575229/the-relationship-between-the-score-on-a-simple-measure-of-cognitive-function-incident-cvd-in-people-with-diabetes-a-post-hoc-epidemiological-analysis-from-the-accord-mind-study
#19
Tali Cukierman-Yaffe, Hertzel C Gerstein, Michael E Miller, Lenore J Launer, Jeff Williamson, Karen R Horowitz, Faramarz Ismail-Beigi, Ronald M Lazar
Context and Objective: Diabetes is associated with a greater risk for incident cardio-vascular disease and for cognitive dysfunction. This study aimed to investigate, in people with Type 2 diabetes the association of a simple measure of cognitive function to CVD events and mortality. Design, Setting, Participants, Measurements & Outcomes: The ACCORD trial included persons with long-standing T2D. A sub-study of 2977 (MIND) participants age => 55 years aimed to test the effect of the interventions on brain structure and function...
June 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28570916/theoretical-assessment-and-targeted-modeling-of-tio2-in-reactor-towards-the-scandium-radioisotopes-estimation
#20
Seyedeh Fatemeh Hosseini, Mahdi Sadeghi, Mohammad Reza Aboudzadeh
(47)Sc radioisotope with beta particle emission can be used for targeted radionuclide therapy in nuclear medicine and can be produced by nuclear reactor (with high activities) and accelerator. In this work, the specific activity of (47)Sc with the isotopic impurities produced through irradiating the enriched (47)Tio2 and natural TiO2 targets have been calculated by the MCNPX-2.6 and the TALYS-1.8 codes and also theoretical approach in a fast neutron flux 3×10(13)ncm(-2)s(-1) in the reactor. In addition, the cross sections of (46)Ti(n,p)(46)Sc reaction have been interpolated in the 1-10MeV energy range and compared with the corresponding experimental data, as well...
May 23, 2017: Applied Radiation and Isotopes
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