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https://www.readbyqxmd.com/read/29448079/identifying-the-underlying-causes-of-biological-instability-in-a-full-scale-drinking-water-supply-system
#1
Alina Nescerecka, Talis Juhna, Frederik Hammes
Changes in bacterial concentration and composition in drinking water during distribution are often attributed to biological (in)stability. Here we assessed temporal biological stability in a full-scale distribution network (DN) supplied with different types of source water: treated and chlorinated surface water and chlorinated groundwater produced at three water treatment plants (WTP). Monitoring was performed weekly during 12 months in two locations in the DN. Flow cytometric total and intact cell concentration (ICC) measurements showed considerable seasonal fluctuations, which were different for two locations...
February 6, 2018: Water Research
https://www.readbyqxmd.com/read/29438522/ras-mutation-analysis-in-circulating-tumor-dna-from-patients-with-metastatic-colorectal-cancer-the-ageo-rasanc-prospective-multicenter-study
#2
J B Bachet, O Bouché, J Taieb, O Dubreuil, M L Garcia, A Meurisse, C Normand, J M Gornet, P Artru, S Louafi, F Bonnetain, A Thirot-Bidault, I Baumgaertner, R Coriat, D Tougeron, T Lecomte, F Mary, T Aparicio, L Marthey, V Taly, H Blons, D Vernerey, P Laurent-Puig
Background: RAS mutations are currently sought for in tumor samples, which takes a median of almost 3 weeks in western European countries. This creates problems in clinical situations that require urgent treatment and for inclusion in therapeutic trials that need RAS status for randomization. Analysis of circulating tumor DNA might help to shorten the time required to determine RAS mutational status prior to anti-EGFR antibody therapy for metastatic colorectal cancer. Here we compared plasma versus tissue RAS analysis in a large prospective multicenter cohort...
February 9, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29437917/colocalization-and-disposition-of-cellulosomes-in-clostridium-clariflavum-as-revealed-by-correlative-superresolution-imaging
#3
Lior Artzi, Tali Dadosh, Elad Milrot, Sarah Moraïs, Smadar Levin-Zaidman, Ely Morag, Edward A Bayer
Cellulosomes are multienzyme complexes produced by anaerobic, cellulolytic bacteria for highly efficient breakdown of plant cell wall polysaccharides. Clostridium clariflavum is an anaerobic, thermophilic bacterium that produces the largest assembled cellulosome complex in nature to date, comprising three types of scaffoldins: a primary scaffoldin, ScaA; an adaptor scaffoldin, ScaB; and a cell surface anchoring scaffoldin, ScaC. This complex can contain 160 polysaccharide-degrading enzymes. In previous studies, we proposed potential types of cellulosome assemblies in C...
February 6, 2018: MBio
https://www.readbyqxmd.com/read/29429124/brain-metastasis-in-gastroesophageal-adenocarcinoma-and-her2-status
#4
Dror Limon, Omer Gal, Noa Gordon, Lior Katz, Gali Perl, Ofer Purim, Limor Amit, Salomon M Stemmer, Yulia Kundel, Irit Ben-Aharon, Baruch Brenner, Tali Siegal, Shlomit Yust-Katz
The increased survival of patients with gastroesophageal adenocarcinoma (GAD) following improvements in treatment has been accompanied by a rising incidence of secondary brain metastasis. HER2 amplification/overexpression, which has been associated with an increased risk of brain metastasis in breast cancer, is found in about 20% of patients with GAD. The aim of this study was to evaluate the effect of HER2 status on brain metastasis in GAD. The database of a tertiary cancer center was searched for patients with GAD diagnosed in 2011-2015, and data were collected on clinical characteristics, brain metastasis, HER2 status, and outcome...
February 10, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29422499/single-subject-anxiety-treatment-outcome-prediction-using-functional-neuroimaging
#5
Tali M Ball, Murray B Stein, Holly J Ramsawh, Laura Campbell-Sills, Martin P Paulus
This corrects the article DOI: 10.1038/npp.2013.328.
March 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29417305/anti-nmda-receptor-encephalitis-presenting-as-postpartum-psychosis-a-clinical-description-and-review
#6
Mukku Shiva Shanker Reddy, Harish Thippeswamy, Sundarnag Ganjekar, Madhu Nagappa, Anita Mahadevan, H R Arvinda, Prabha S Chandra, Arun B Taly
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is increasingly being recognised to be associated with protean neuropsychiatric manifestations. Anti-NMDAR encephalitis is considered to be the most common amongst the autoimmune-mediated encephalitic disorders. It is caused by the autoantibodies against GluN1 subunits of N-methyl-D-aspartate (NMDA) receptor and manifests with prominent psychiatric symptoms, especially during the initial phase of illness. Literature anti-NMDAR encephalitis presenting with postpartum psychosis is scant...
February 7, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29405815/the-impact-of-breathing-rate-on-the-cardiac-autonomic-dynamics-among-children-with-cerebral-palsy-compared-to-typically-developed-controls
#7
Taly Amichai, Sharon Eylon, Itai Berger, Michal Katz-Leurer
PURPOSE: To describe the immediate effect of breathing rate on heart rate (HR) and heart rate variability (HRV) in children with cerebral palsy (CP) and a control group of typically developed (TD) age and gender-matched children. METHODS: Twenty children with CP at gross motor function classification system levels I-III and 20 TD children aged 6-11 participated in the study. HR was monitored at rest and during paced breathing with biofeedback. Respiratory measures were assessed by KoKo spirometry...
February 6, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29397083/when-proactivity-fails-an-electrophysiological-study-of-establishing-reference-in-schizophrenia
#8
Gina R Kuperberg, Tali Ditman, Arim Choi Perrachione
BACKGROUND: Schizophrenia is characterized by abnormalities in referential communication, which may be linked to more general deficits in proactive cognitive control. We used event-related potentials to probe the timing and nature of the neural mechanisms engaged as people with schizophrenia linked pronouns to their preceding referents during word-by-word sentence comprehension. METHODS: We measured event-related potentials to pronouns in two-clause sentences in 16 people with schizophrenia and 20 demographically matched control participants...
January 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29395280/pediatric-cochlear-implant-soft-failure
#9
David Ulanovski, Joseph Attias, Meirav Sokolov, Tali Greenstein, Eyal Raveh
PURPOSE: Hard cochlear implant failures are diagnosed by objective tests whereas soft failures are suspected on the basis of clinical signs and symptoms. This study reviews our experience with children in tertiary pediatric medical center who underwent revision cochlear implantation, with emphasis on soft failures. MATERIALS AND METHODS: Children (age<18years) who underwent revision cochlear implantation from 2000 to 2012 were identified by database search. Pre- and post-explantation data were collected...
December 19, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29388901/alliance-rupture-and-resolution-in-dialectical-behavior-therapy-for-borderline-personality-disorder
#10
Tali Boritz, Ryan Barnhart, Catherine F Eubanks, Shelley McMain
The aim of this exploratory study was to investigate alliance rupture and resolution processes in the early sessions of a sample of clients who underwent 1 year of standard dialectical behavior therapy (DBT) for borderline personality disorder (BPD). Participants were three recovered and three unrecovered clients drawn from the DBT arm of a randomized controlled trial that compared the clinical and cost-effectiveness of DBT and general psychiatric management. Alliance rupture and resolution processes were coded using the observer-based Rupture Resolution Rating Scale...
January 2018: Journal of Personality Disorders
https://www.readbyqxmd.com/read/29387510/accessory-ossicles-of-the-foot-and-ankle-disorders-and-a-review-of-the-literature
#11
REVIEW
Nigar Keles-Celik, Ozkan Kose, Rahime Sekerci, Gunes Aytac, Adil Turan, Ferhat Güler
Accessory ossicles of the foot and ankle are normal variants of bone development that usually remain asymptomatic. However, they may be involved in various disorders and become a source of pain such as in fractures, dislocations, degenerative changes, osteonecrosis, osteoarthritis, osteochondral lesions, avascular necrosis, and irritation or impingement of adjacent soft tissues. Hence, during the assessment of the situations above, knowledge about these little-known ossicles could be very important to reach the correct diagnosis...
November 26, 2017: Curēus
https://www.readbyqxmd.com/read/29359363/comparison-of-efficiency-of-in-vitro-cloned-sheep-embryo-production-by-conventional-somatic-cell-nuclear-transfer-and-handmade-cloning-technique
#12
S Khan, M Tali, A Khan, S Bhat, A Ashraf, M H Bhat, F Khan, R A Shah
Conventional somatic cell nuclear transfer (SCNT) technique of in vitro production of cloned embryos involves use of costly and complicated micromanipulators. Handmade cloning (HMC) technique has been applied as efficient and cost-effective alternative in many livestock species. The aim of the present study was to compare the efficiency of in vitro production and in vitro development of cloned sheep embryos by the two techniques. Cloned embryos were produced by conventional SCNT using micromanipulator apparatus and by HMC technique...
January 22, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29353736/mitochondrial-leukoencephalopathies-a-border-zone-between-acquired-and-inherited-white-matter-disorders-in-children
#13
Parayil Sankaran Bindu, Kothari Sonam, Shwetha Chiplunkar, Periyasamy Govindaraj, Madhu Nagappa, Chetan Chandrakanth Vekhande, Hanumanthapura R Aravinda, Jn Jessiena Ponmalar, Anita Mahadevan, Narayanappa Gayathri, Mm Srinivas Bharath, Sanjib Sinha, Arun B Taly
BACKGROUND: There is emerging evidence implicating mitochondrial dysfunction in the pathogenesis of acquired demyelinating disorders such as multiple sclerosis. On the other hand, some of the primary mitochondrial disorders such as mitochondrial leukoencephalopathies exhibit evidence of neuroinflammation on MRI. The inter-relationship between mitochondrial disorders and episodic CNS inflammation needs exploration because of the therapeutic implications. OBJECTIVE: We sought to analyze the clinical course and MRI characteristics in a cohort of patients with mitochondrial leukoencephalopathy to determine features, if any, that mimic primary demyelinating disorders...
January 6, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29347832/wire-placement-in-the-sustentaculum-tali-using-a-2d-projection-based-software-application-for-mobile-c-arms-cadaveric-study
#14
Benedict Swartman, Dirk Frere, Wei Wei, Marc Schnetzke, Stephan Grechenig, Amir Matityahu, Nils Beisemann, Holger Keil, Jochen Franke, Paul Alfred Grützner, Sven Yves Vetter
BACKGROUND: Indirect screw fixation of the sustentaculum tali in the lateral-medial direction can be challenging due to the complex calcaneal anatomy. A novel 2-dimensional (2D) projection-based software application detects Kirschner wires (K-wires) and visualizes their intended direction as a colored trajectory. The aim of this prospectively randomized cadaver study was to investigate whether the software would facilitate the indirect K-wire placement in the sustentaculum tali. METHODS: In 20 cadaver foot specimens, K-wires were placed indirectly in the sustentaculum tali by an experienced and an inexperienced surgeon, with and without using the application...
January 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29346803/author-response-penetrance-of-the-lhon-mutation-m-11778g-a-may-depend-on-factors-other-than-haplotype-or-heteroplasmy-rate
#15
Nahid Akhtar Khan, Periyasamy Govindaraj, Nagasamy Soumittra, Sonika Sharma, Sundaramoorthy Srilekha, Selvakumar Ambika, Ayyasamy Vanniarajan, Angamuthu Kanikannan Meena, Megha S Uppin, Challa Sundaram, Parayil Sankaran Bindu, Narayanappa Gayathri, Arun B Taly, Kumarasamy Thangaraj
No abstract text is available yet for this article.
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29343870/-la-legge-italiana-n-24-2017-sulla-responsabilit%C3%A3-penale-del-medico-una-riforma-che-non-risolve-i-problemi-della-pratica-psichiatrica
#16
Gianluca Montanari Vergallo, Simona Zaami, Natale Mario Di Luca, Giuseppe Bersani, Raffaella Rinaldi
RIASSUNTO. Da anni gli psichiatri vivono in maniera pressante il rischio di essere sottoposti a processo penale per responsabilità professionale. Una delle ragioni di questa situazione sta nel fatto che il professionista non può contare su regole di comportamento chiare. Anzi, proprio in psichiatria è possibile che un giudice consideri colposa una condotta che per un altro Tribunale non è sanzionabile, come nei casi di dimissioni ospedaliere. Per rimediare a questa situazione il legislatore italiano ha emanato la legge 8 marzo 2017, n...
November 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29338291/indications-for-surgical-repair-of-type-1-laryngeal-cleft
#17
Craig E Berzofsky, Tali Lando, Sandra Ettema, Jennifer Nelson, Gayle Woodson
OBJECTIVES: Type 1 laryngeal cleft (T1LC) is a congenital deficiency in the posterior glottis, resulting in a communication between the hypopharynx and glottis. No consensus treatment paradigm exists for timing and criteria for patient selection for surgical repair. Our goal is to assess whether patient characteristics can help predict improvement after surgery. METHODS: After Institutional Review Board exemption, a retrospective chart review was performed for patients undergoing surgery to diagnose a T1LC...
January 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29337838/comparison-between-small-and-large-bowel-intussusception-in-children-the-experience-of-a-large-tertiary-care-pediatric-hospital
#18
Hila Levinson, Tali Capua, Dennis Scolnik, Ayelet Rimon, Lotan Salomon, Miguel Glatstein
BACKGROUND: Intussusception is the most common cause of intestinal obstruction in young children, and delayed diagnosis may lead to serious sequelae. The objective of this study was to determine the prevalence of ileoileal intussusception and to document and compare clinical outcomes with ileocolic intussusception. METHODS: A retrospective cohort study of children with an abdominal ultrasound that diagnosed intussusception. Clinical data and diagnostic studies were retrieved, to compare ileoileal with ileocolic intussusception...
January 15, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29337837/accidental-rivaroxaban-intoxication-in-a-boy-some-lessons-in-managing-new-oral-anticoagulants-in-children
#19
Julieta Weirthein, Dennis Scolnik, Nili Yanai Milshtein, Tali Capua, Miguel Glatstein
Novel oral anticoagulants offer equivalent or improved therapeutic profiles compared with warfarin, with less risk of bleeding, no interactions with food, and no need for routine laboratory monitoring. Caution must be exercised in using these drugs in certain patient populations, for example, renal insufficiency, those receiving additional antithrombotic therapy, those with questionable compliance, children, and those with a high risk of gastrointestinal bleeding. One of the novel oral anticoagulants, rivaroxaban, is a direct Factor Xa inhibitor, used to reduce risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, deep vein thrombosis, and pulmonary embolism...
January 15, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29336215/non-invasive-real-time-assessment-of-cell-viability-in-a-three-dimensional-tissue
#20
Seyed Hossein Mahfouzi, Ghassem Amoabediny, Ali Doryab, Seyed Hamid Safiabadi-Tali, Mostafa Ghanei
Maintaining cell viability within 3D tissue engineering scaffolds is an essential step toward a functional tissue or organ. Assessment of cell viability in 3D scaffolds is necessary to control and optimize tissue culture process. Monitoring systems based on respiration activity of cells (e.g., oxygen consumption) have been used in various cell cultures. In this research, an online monitoring system based on respiration activity was developed to monitor cell viability within acellular lung scaffolds. First, acellular lung scaffolds were recellularized with human umbilical cord vein endothelial cells, and then, cell viability was monitored during a 5-day period...
January 16, 2018: Tissue Engineering. Part C, Methods
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