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https://www.readbyqxmd.com/read/29689949/taxonomic-revision-of-israeli-snakes-belonging-to-the-platyceps-rhodorachis-species-complex-reptilia-squamata-colubridae
#1
Guy Sinaiko, Tali Magory-Cohen, Shai Meiri, Roi Dor
The Platyceps rhodorachis species complex encompasses a widespread group of morphologically similar colubrid snakes. The number and identities of species from this complex in Israel have recently been debated. Studies from the previous decade concluded that there are two species in Israel and its vicinity (compared with one previously recognized), but their identity remained contested. We estimated the number of species and their taxonomic identity using morphological and molecular data. We found some evidence for clinal variation in many of the characters used to differentiate the species, and a great overlap in traits of putative species...
February 15, 2018: Zootaxa
https://www.readbyqxmd.com/read/29688643/-fmr1-premutation-carriers-are-they-really-asymptomatic
#2
REVIEW
Shai Elizur, Michal Berkenstadt, Liat Ries-Levavi, Noah Gruber, Orit Pinhas-Hamiel, Sharon Hassin-Baer, Annick Raas-Rothschild, Hila Raanani, Tali Cukierman-Yaffe, Raoul Orvieto, Yoram Cohen, Lidia Gabis
Fragile X Syndrome (FXS), the most common form of inherited mental retardation, is caused by a trinucleotide repeat expansion (CGG) in the 5'-untranslated region of the Fragile X Mental Retardation 1 (FMR1) gene located at Xq27.3. Patients with fragile X -related mental retardation, carry the full mutation CGG-repeat expansions (>200 CGG repeats), which are generally accompanied by hypermethylation of the promoter region, with the consequent transcriptional silencing of the FMR1 gene and absence of the encoded FMR1 protein (FMRP)...
April 2018: Harefuah
https://www.readbyqxmd.com/read/29688177/trans-catheter-aortic-valve-implantation-versus-conservative-treatment-in-chronic-kidney-disease-patients
#3
Tali Steinmetz, Guy Witberg, Avry Chagnac, Hefziba Green, Alexander Sagie, Benaya Rozen-Zvi, Ran Kornowski
AIMS: There are no studies comparing trans-catheter aortic valve implantation to conservative management in patients with chronic kidney disease stage 3-5 and severe aortic stenosis. We saught to compare mortality rate and change in renal function in this patient population. METHODS AND RESULTS: Single center retrospective-cohort study that included all patients with chronic kidney disease stage 3-5 and severe aortic stenosis who underwent TAVI or treated conservatively between 2010-2015...
April 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29686646/therapy-induced-neuroplasticity-in-chronic-aphasia-after-phonological-component-analysis-a-matter-of-intensity
#4
Karine Marcotte, Laura Laird, Tali Bitan, Jed A Meltzer, Simon J Graham, Carol Leonard, Elizabeth Rochon
Despite the growing evidence regarding the importance of intensity and dose in aphasia therapy, few well-controlled studies contrasting the effects of intensive and non-intensive treatment have been conducted to date. Phonological components analysis (PCA) treatment for anomia has been associated with improvements in some patients with chronic aphasia; however, the effect of treatment intensity has not yet been studied with PCA. Thus, the aim of the present study was to identify the effect of intensity on neural processing associated with word retrieval abilities after PCA treatment...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29674593/unexpected-reversal-of-c-3-versus-c-4-grass-response-to-elevated-co-2-during-a-20-year-field-experiment
#5
Peter B Reich, Sarah E Hobbie, Tali D Lee, Melissa A Pastore
Theory predicts and evidence shows that plant species that use the C4 photosynthetic pathway (C4 species) are less responsive to elevated carbon dioxide ( e CO2 ) than species that use only the C3 pathway (C3 species). We document a reversal from this expected C3 -C4 contrast. Over the first 12 years of a 20-year free-air CO2 enrichment experiment with 88 C3 or C4 grassland plots, we found that biomass was markedly enhanced at e CO2 relative to ambient CO2 in C3 but not C4 plots, as expected. During the subsequent 8 years, the pattern reversed: Biomass was markedly enhanced at e CO2 relative to ambient CO2 in C4 but not C3 plots...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29673758/measurements-of-the-talus-in-the-assessment-of-population-affinity
#6
Mubarak A Bidmos, Manisha R Dayal, Oyelola A Adegboye
As part of their routine work, forensic anthropologists are expected to report population affinity as part of the biological profile of an individual. The skull is the most widely used bone for the estimation of population affinity but it is not always present in a forensic case. Thus, other bones that preserve well have been shown to give a good indication of either the sex or population affinity of an individual. In this study, the potential of measurements of the talus was investigated for the purpose of estimating population affinity in South Africans...
March 29, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29660992/next-of-kin-s-notification-of-patient-s-death-a-qualitative-and-quantitative-preliminary-analysis
#7
Sasson Menahem, Tali Samson, Pesach Shvartzman
BACKGROUND: There are no published studies on notification of death by a next of kin to the treating medical staff. AIM: To explore the content and circumstances of death notifications by next of kin to the treating medical staff in a palliative home care unit. DESIGN: A cross-sectional study that combines qualitative and quantitative analysis. SETTING: Assessment of 153 telephone death notifications by a next of kin to the treating medical staff...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29660300/the-major-orphan-forms-of-ichthyosis-are-characterized-by-systemic-t-cell-activation-and-th-17-tc-17-th-22-tc22-polarization-in-blood
#8
Tali Czarnowicki, Helen He, Alexandra Leonard, Kunal Malik, Shai Magidi, Stephanie Rangel, Krishna Patel, Kara Ramsey, Morgan Murphrey, Teresa Song, Yeriel Estrada, Hue-Chi Wen, James G Krueger, Emma Guttman-Yassky, Amy S Paller
The ichthyoses are rare skin disorders with immune and barrier aberrations. Identifying blood phenotypes may advance targeted-therapeutics.We aimed to compare frequencies of skin homing/CLA+ vs. systemic/CLA- "polar" CD4+ /CD8+ and activated T-cell subsets in ichthyosis vs. atopic dermatitis/AD, psoriasis and control blood, with appropriate clinical correlations. Flow cytometry was used to measure IFN-γ, IL-13, IL-9, IL-17, and IL-22 cytokines in CD4+ /CD8+ T-cells, with ICOS and HLA-DR defining mid- and long-term T-cell activation, respectively...
April 13, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29658301/avoiding-pitfalls-of-tibiotalocalcaneal-nail-malposition-with-internal-rotation-axial-heel-view
#9
Ryan Callahan, Paul Juliano, Umur Aydogan, Justin Clayton
BACKGROUND: Tibiotalocalcaneal (TTC) nails are often used for complex hind foot arthrodesis and deformity correction. The natural valgus alignment of the hindfoot creates a challenge to optimum placement of the guidewire and eventual nail with a straight or valgus-curved nail. METHODS: Five fresh frozen cadavers were used for placement of a TTC guidewire with standard anterior-posterior (AP), lateral, and Harris axial heel views as a reference for proper placement...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29656563/factors-affecting-publication-in-peer-reviewed-journals-of-abstracts-presented-from-2008-to-2012-acvo-meetings
#10
Ellison Bentley, Megan Koester, Tali Bdolah-Abram, Nadav Yair, Ron Ofri
PURPOSE: To examine variables that affect publication of ACVO meeting abstracts in peer-reviewed journals and compare results to ECVO publication rate (PR). METHODS: Published papers were identified via online searches for abstracts from 2008 to 2012 ACVO/ECVO meetings. Variables analyzed (via Pearson's chi-Squared test) included the following: oral presentation/poster, type of abstract (clinical/basic science/case report), species, ocular tissue, nationality, funding, first/last/any author a diplomate, resident as first author, and author affiliation (private practice/university)...
April 14, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29655963/abortion-training-in-us-obstetrics-and-gynecology-residency-programs
#11
Jody E Steinauer, Jema K Turk, Tali Pomerantz, Kristin Simonson, Lee A Learman, Uta Landy
BACKGROUND: Nearly 15 years ago, 51% of US obstetrics and gynecology residency training program directors reported that abortion training was routine, 39% reported training was optional, and 10% did not have training. The status of abortion training now is unknown. OBJECTIVE: To determine the current status of abortion training in obstetrics and gynecology residency programs. STUDY DESIGN: Through surveying program directors of US obstetrics and gynecology residency training programs, we conducted a cross-sectional study on the availability and characteristics of abortion training...
April 12, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29653116/asian-atopic-dermatitis-serum-is-characterized-by-th2-th22-activation-highly-correlated-with-non-lesional-skin-measures
#12
Huei-Chi Wen, Tali Czarnowicki, Shinji Noda, Kunal Malik, Ana B Pavel, Saeko Nakajima, Tetsuya Honda, Jung U Shin, Hemin Lee, Margaret Chou, Yeriel Estrada, Xiuzhong Zheng, Hui Xu, James G Krueger, Kwang-Hoon Lee, Kenji Kabashima, Emma Guttman-Yassky
Asian AD serum is characterized by prominent Th2 and Th22 signatures that correlate with the non-lesional skin profile, suggesting that serum phenotyping can serve as a surrogate for assessing disease extent beyond apparent AD lesions.
April 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29629884/aspetti-deontologici-e-giuridici-della-responsabilit%C3%A3-professionale-del-chirurgo-in-italia-evoluzione-storica-a-partire-dal-900
#13
Nicola Picardi
È pleonastico ricordare che ogni individuo raziocinante delle essere responsabile delle sue azioni: deve agire con la coscienza degli scopi che si propone evitando possibili conseguenze negative dei suoi atti. In ambito medico questo tipo di responsabilità è codificata con le norme della "deontologia". Per secoli l'arte terapeutica è stata praticata da individui dotati di una particolare vocazione ed una particolare cultura acquisita da Maestri dell'arte ancor prima che dalla propria esperienza, con nozioni di erboristeria e di elementari conoscenze anatomiche e di fisiologia, circondati da un'aura sacerdotale e da un rispetto derivante dal timore e dall'ammirazione per il coraggio e auspicabilmente dai successi, e facendo riferimento nell'occidente mediterraneo alle regole operative fissate nel Giuramento di Ippocrate, di significato tra il sacro ed il deontologico...
2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29629784/implementing-the-bounce-back-trauma-intervention-in-urban-elementary-schools-a-real-world-replication-trial
#14
Catherine DeCarlo Santiago, Tali Raviv, Anna Maria Ros, Stephanie K Brewer, Laura M L Distel, Stephanie A Torres, Anne K Fuller, Krystal M Lewis, Claire A Coyne, Colleen Cicchetti, Audra K Langley
The current study provides the first replication trial of Bounce Back, a school-based intervention for elementary students exposed to trauma, in a different school district and geographical area. Participants in this study were 52 1st through 4th graders (Mage = 7.76 years; 65% male) who were predominately Latino (82%). Schools were randomly assigned to immediate treatment or waitlist control. Differential treatment effects (Time × Group Interaction) were found for child-reported posttraumatic stress disorder (PTSD) and parent-reported child coping, indicating that the immediate treatment group showed greater reductions in PTSD and improvements in coping compared with the delayed group...
March 2018: School Psychology Quarterly
https://www.readbyqxmd.com/read/29627453/role-of-circulating-tumor-dna-in-the-management-of-patients-with-colorectal-cancer
#15
Emilie Moati, Valérie Taly, Audrey Didelot, Géraldine Perkins, Hélène Blons, Julien Taieb, Pierre Laurent-Puig, Aziz Zaanan
Colorectal cancer is a major health burden with a prognosis that has been improved with the progresses in diagnosis and the advance of chemotherapy and personalized medicine. However, because of intra-tumor heterogeneity, clonal evolution and selection, tumors often develop resistance to treatments. "Liquid biopsy" is a minimally invasive method, based on analysis of tumor-specific material in peripheral blood samples of patients. Analysis of tumor specific genetic or epigenetic alterations in cell-free circulating nucleic acids may reflect the molecular heterogeneity of the underlying disease process and serial testing could allow to monitor its temporal genomic changing without using re-biopsy...
April 4, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29624673/the-bone-marrow-is-patrolled-by-nk-cells-that-are-primed-and-expand-in-response-to-systemic-viral-activation
#16
Idan Milo, Ronnie Blecher-Gonen, Zohar Barnett-Itzhaki, Raz Bar-Ziv, Orna Tal, Irina Gurevich, Tali Feferman, Ingo Drexler, Ido Amit, Philippe Bousso, Guy Shakhar
The bone marrow hosts NK cells whose distribution, motility and response to systemic immune challenge are poorly understood. At steady state, two-photon microscopy of the bone marrow in Ncr1gfp/+ mice captured motile NK cells interacting with dendritic cells. NK cells expressed markers and effector molecules of mature cells. Following poly (I:C) injection, RNA-Seq of NK cells revealed three phases of transcription featuring immune response genes followed by posttranscriptional processes and proliferation. Functionally, poly (I:C) promoted upregulation of granzyme B, enhanced cytotoxicity in vitro and in vivo, and, in the same individual cells, triggered proliferation...
April 6, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29623220/high-prevalence-of-hypertension-in-ethiopian-and-non-ethiopian-hiv-infected-adults
#17
Maya Korem, Tali Wallach, Michael Bursztyn, Shlomo Maayan, Karen Olshtain-Pops
Objectives: Prevalence of hypertension has not been studied in the Ethiopian HIV-infected population, which represents 60% of the patients in our AIDS unit. Our aim was to identify risk factors and characterize the prevalence of hypertension in the population monitored at our unit. Methods: A retrospective chart review categorized subjects according to their blood pressure levels. Hypertension prevalence was determined and stratified according to variables perceived to contribute to elevated blood pressure...
2018: International Journal of Hypertension
https://www.readbyqxmd.com/read/29617673/mitochondrial-complex-i-inhibitors-expose-a-vulnerability-for-selective-killing-of-pten-null-cells
#18
Adam Naguib, Grinu Mathew, Colleen R Reczek, Kaitlin Watrud, Alexandra Ambrico, Tali Herzka, Irene Casanova Salas, Matthew F Lee, Nour El-Amine, Wu Zheng, M Emilia Di Francesco, Joseph R Marszalek, Darryl J Pappin, Navdeep S Chandel, Lloyd C Trotman
A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic compounds on Pten-/- ;Trp53-/- fibroblasts and their Pten-WT reference. Highly selective killing of Pten-null cells can be achieved by deguelin, a natural insecticide. Deguelin eliminates Pten-deficient cells through inhibition of mitochondrial complex I (CI). Five hundred-fold higher drug doses are needed to obtain the same killing of Pten-WT cells, even though deguelin blocks their electron transport chain equally well...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29615047/potent-antiplasmodial-extracts-and-fractions-from-terminalia-mantaly-and-terminalia-superba
#19
Cedric D J Mbouna, Rufin M T Kouipou, Rodrigue Keumoe, Lauve R Y Tchokouaha, Patrick V T Fokou, Brice M T Tali, Dinkar Sahal, Fabrice F Boyom
BACKGROUND: The emergence and spread of malaria parasites resistant to artemisinin-based combination therapy stresses the need for novel drugs against malaria. Investigating plants used in traditional medicine to treat malaria remains a credible option for new anti-malarial drug development. This study was aimed at investigating the antiplasmodial activity and selectivity of extracts and fractions from Terminalia mantaly and Terminalia superba (Combretaceae) that are used in Cameroon to treat malaria...
April 3, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29605591/mutation-and-methylation-analysis-of-circulating-tumor-dna-can-be-used-for-follow-up-of-metastatic-colorectal-cancer-patients
#20
Nele Boeckx, Ken Op de Beeck, Matthias Beyens, Vanessa Deschoolmeester, Christophe Hermans, Peggy De Clercq, Sonia Garrigou, Corinne Normand, Els Monsaert, Konstantinos Papadimitriou, Pierre Laurent-Puig, Patrick Pauwels, Guy Van Camp, Valerie Taly, Marc Peeters
BACKGROUND: Targeted therapies, although contributing to survival improvement in metastatic colorectal cancer (mCRC), are expensive and may cause adverse effects. Therefore, confirming that patients are responding to these therapies is extremely important. Currently, follow-up is performed using radiographic evaluation, which has its limitations. Liquid biopsies, reflecting real-time tumor characteristics, hold great potential in monitoring tumor disease. PATIENTS AND METHODS: Blood samples were collected at different time points during treatment of 24 mCRC patients...
February 22, 2018: Clinical Colorectal Cancer
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