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https://www.readbyqxmd.com/read/27926939/a-bystander-mechanism-explains-the-specific-phenotype-of-a-broadly-expressed-misfolded-protein
#1
Lauren Klabonski, Ji Zha, Lakshana Senthilkumar, Tali Gidalevitz
Misfolded proteins in transgenic models of conformational diseases interfere with proteostasis machinery and compromise the function of many structurally and functionally unrelated metastable proteins. This collateral damage to cellular proteins has been termed 'bystander' mechanism. How a single misfolded protein overwhelms the proteostasis, and how broadly-expressed mutant proteins cause cell type-selective phenotypes in disease are open questions. We tested the gain-of-function mechanism of a R37C folding mutation in an endogenous IGF-like C...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27926628/variants-of-tph2-interact-with-fast-visual-processing-as-assessed-by-metacontrast
#2
Margus Maksimov, Mariliis Vaht, Carolina Murd, Jaanus Harro, Talis Bachmann
Sensitivity to threatening or otherwise unpleasant visual stimuli has become a widely used measure of potential vulnerability/resilience. Basically, experiments using this strategy present brief stimuli, often followed by a mask, and individuals' sensitivity is measured. However, it has not been asked whether the individual differences in threat detection or adaptive resilience associated with genetic variability-related endophenotypes might be just a function of some basic visual functions involved in processing and reporting brief visual stimuli without any emotional content...
December 6, 2016: Neuroreport
https://www.readbyqxmd.com/read/27921340/brain-activation-during-fear-extinction-predicts-exposure-success
#3
Tali Manber Ball, Sarah E Knapp, Martin P Paulus, Murray B Stein
BACKGROUND: Exposure therapy, a gold-standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC) and more amygdala activation, but the relationship between these deficits and exposure outcome is unknown. We tested whether anxious individuals who demonstrate better extinction learning report greater anxiety reduction following brief exposure...
December 6, 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/27921070/accuracy-of-patient-specific-organ-dose-estimates-obtained-using-an-automated-image-segmentation-algorithm
#4
Taly Gilat Schmidt, Adam S Wang, Thomas Coradi, Benjamin Haas, Josh Star-Lack
The overall goal of this work is to develop a rapid, accurate, and automated software tool to estimate patient-specific organ doses from computed tomography (CT) scans using simulations to generate dose maps combined with automated segmentation algorithms. This work quantified the accuracy of organ dose estimates obtained by an automated segmentation algorithm. We hypothesized that the autosegmentation algorithm is sufficiently accurate to provide organ dose estimates, since small errors delineating organ boundaries will have minimal effect when computing mean organ dose...
October 2016: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27918917/activation-cross-sections-of-deuteron-induced-reactions-on-silver-in-the-33-50mev-energy-range
#5
F Ditrói, F Tárkányi, S Takács, A Hermanne, A V Ignatyuk
Excitation functions were measured for the (nat)Ag(d,x)(105,104)Cd, (110)(m,108m,106m,105g,104g)Ag and (101)Pd, (105,101m)Rh reactions over the energy range 33-50MeV by using the stacked foil activation technique and subsequent high-resolution gamma-spectrometry. We present the first experimental cross section data above 40MeV for all of these reactions and the first experimental cross section data for (nat)Ag(d,x)(108m,104g)Ag and (105,103)Rh. The experimental data are compared with results of the model calculations performed with the ALICE-D, EMPIRE-D theoretical nuclear reaction model codes and with the TALYS code results as available in the TENDL-2014 and -2015 on-line libraries...
November 27, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27918258/prolonged-excretion-of-type-2-poliovirus-from-a-primary-immune-deficient-patient-during-the-transition-to-a-type-2-poliovirus-free-world-israel-2016
#6
Merav Weil, Lester M Shulman, Sophia Heiman, Tali Stauber, Jacqueline Alfandari, Leah Weiss, Ilana Silberstein, Viki Indenbaum, Ella Mendelson, Danit Sofer
Wild poliovirus type-2 has been eradicated, use of live type-2 vaccine has been terminated globally, and all type-2 polioviruses are under strict laboratory containment protocols. Re-emergence may arise from prolonged asymptomatic excretion of poliovirus by hospitalised primary immune deficient (PID) patients, as described here, through repeated exposure of close contacts to high titres of infected material. At this transition time, PID patients should be screened and hospital containment protocols updated in parallel with laboratory containment...
November 24, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27909218/erythrocyte-survival-is-controlled-by-microrna-142
#7
Natalia Rivkin, Elik Chapnik, Alexander Mildner, Gregory Barshtein, Ziv Porat, Elena Kartvelishvily, Tali Dadosh, Yehudit Birger, Gail Amir, Saul Yedgar, Shai Izraeli, Steffen Jung, Eran Hornstein
Hematopoietic-specific miR-142 is critical regulator of various blood cell lineages, but its role in erythrocytes is unexplored. Here, we characterize miR-142 impact on erythrocyte physiology and molecular cell biology, using a mouse loss of function allele. We report that miR-142 is required for maintaining the typical erythrocyte biconcave shape and structural resilience, for normal metabolism of reactive oxygen species (ROS) and for overall lifespan. miR-142 further controls actin filament homeostasis and membrane skeleton organization...
December 1, 2016: Haematologica
https://www.readbyqxmd.com/read/27901259/neurological-manifestations-of-chikungunya-and-zika-infections
#8
Talys J Pinheiro, Luis F Guimarães, Marcus Tulius T Silva, Cristiane N Soares
The epidemics of Chikungunya virus (CHIKV) and Zika virus (ZIKV) infections have been considered the most important epidemiological occurrences in the Americas. The clinical picture of CHIKV infection is characterized by high fever, exanthema, myalgia, headaches, and arthralgia. Besides the typical clinical picture of CHIKV, atypical manifestations of neurological complications have been reported: meningo-encephalitis, meningoencephalo-myeloradiculitis, myeloradiculitis, myelitis, myeloneuropathy, Guillain-Barré syndrome and others...
November 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27899880/elbow-matching-accuracy-in-young-and-elderly-humans-under-unusual-mechanical-constraints
#9
Vera L Talis, Yuri S Levik
Experiment was carried out to study the proprioception accuracy of elderly (61-83 years old) and young (22-36 years old) subjects during contralateral elbow matching in sagittal plane. The subjects performed the task under ordinary condition and under experimental condition (matching forearm attached to the rocking cylindrical platform of low (LS), or high (HS) height, so that the elbow flexion was associated with tilting movement of the support and with backward movement of the upper arm). Control matching of young and elderly subjects does not differ significantly in terms of constant and absolute error...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27888956/improving-adherence-in-hospitalized-patients-diagnosed-with-schizophrenia-an-integrative-one-on-one-intervention
#10
Sagit Dahan, Pnina Behrbalk, Tali Stolovy, Chaya Greenberger
OBJECTIVE: This study examined an individualized integrative nursing intervention for improving attitude and adherence. METHODS: The sample included 60 patients, randomly assigned to an experimental or control group. Measures included The Visual Analog Scale for Assessing Treatment Compliance and the Drug Attitude Inventory (DAI- 10). RESULTS: Significant differences were found in attitude and reported adherence for the experimental group, before and after...
December 2016: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/27886031/pertussis-in-north-central-and-northwestern-regions-of-algeria
#11
Nabila Benamrouche, Hassiba Tali Maamar, Malika Lazri, Sonia Hasnaoui, Abdelkarim Radoui, Ourida Lafer, Rachida Boukari, Chawki Kaddache, Zakia Arrada, Kheira Rahal
INTRODUCTION: Pertussis outbreaks continue to occur in many countries despite high vaccination coverage. Under-diagnosed cases in adolescents and adults may result in increased transmission to infants, who are at risk of severe pertussis. Additional measures to protect both groups should be considered. METHODOLOGY: Nasopharyngeal samples and sera were collected from patients and household contacts with clinically suspected pertussis. Diagnoses were confirmed by culture, real-time polymerase chain reaction (PCR), and serology...
November 24, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27871008/production-cross-sections-of-radioisotopes-from-3-he-particle-induced-nuclear-reactions-on-natural-titanium
#12
F Szelecsényi, Z Kovács, K Nagatsu, M-R Zhang, K Suzuki
Excitation functions were measured using the stacked-foil method for the (nat)Ti((3)He,x)(44m)Sc, (46m+g)Sc, (47)Sc, (48)Sc, (48)V and (48)Cr nuclear processes up to 68MeV. Our new cross-section data were compared with the earlier reported values as well as the evaluated theoretical predictions by means of the TALYS 1.6 code as compiled in the TENDL-2015 library. The new data show acceptable agreement with the previous experimental values in the overlapping energy regions, however only a partial agreement was found in the case of the results of the nuclear reaction model code...
January 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27869871/-impatto-dei-congressi-medici-e-come-renderli-utili
#13
Donald Nicolson
Riassunto. I congressi medici hanno finora in gran parte eluso l'esame empirico, nonostante il dispendio di tempo e l'impegno di quanti vi prendono parte. In questo articolo vengono presi in esame alcuni esempi di conferenze, quali il Cochrane Colloquium, dalle quali trarre importanti insegnamenti circa il loro impatto. Il viaggio, il luogo e la data dove si svolgono tali congressi possono costituire un impedimento alla partecipazione dei congressisti, con ripercussioni su quanto verrà presentato e discusso...
November 2016: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/27867725/phase-stretch-transform-for-super-resolution-localization-microscopy
#14
Tali Ilovitsh, Bahram Jalali, Mohammad H Asghari, Zeev Zalevsky
Super-resolution localization microscopy has revolutionized the observation of living structures at the cellular scale, by achieving a spatial resolution that is improved by more than an order of magnitude compared to the diffraction limit. These methods localize single events from isolated sources in repeated cycles in order to achieve super-resolution. The requirement for sparse distribution of simultaneously activated sources in the field of view dictates the acquisition of thousands of frames in order to construct the full super-resolution image...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27861978/circulating-cla-t-cells-in-atopic-dermatitis-and-their-possible-role-as-peripheral-biomarkers
#15
REVIEW
Tali Czarnowicki, Luis F Santamaria-Babí, Emma Guttman-Yassky
Cutaneous lymphocyte-associated antigen (CLA(+) ) T-cells are specialized for skin homing and represent the main T-cell population in atopic dermatitis (AD) lesions. CLA(+) is expressed on the surface of circulating CD45RO(+) memory T-cells and most skin infiltrating T-cells. Mechanistic studies and thus treatment advancements are limited by the need of large number of skin biopsies. Circulating CLA(+) T-cells may be a reliable surrogate marker of the inflammatory events occurring in the skin, and thus the evaluation of CLA(+) T-cells in the blood may eliminate the need for skin biopsies...
November 8, 2016: Allergy
https://www.readbyqxmd.com/read/27854317/modulating-the-gut-micro-environment-in-the-treatment-of-intestinal-parasites
#16
REVIEW
Luis Vitetta, Emma Tali Saltzman, Tessa Nikov, Isabelle Ibrahim, Sean Hall
The interactions of micro-organisms cohabitating with Homo sapiens spans millennia, with microbial communities living in a symbiotic relationship with the host. Interacting to regulate and maintain physiological functions and immunological tolerance, the microbial community is able to exert an influence on host health. An example of micro-organisms contributing to an intestinal disease state is exhibited by a biodiverse range of protozoan and bacterial species that damage the intestinal epithelia and are therefore implicated in the symptoms of diarrhea...
November 16, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27836628/optimistic-update-bias-holds-firm-three-tests-of-robustness-following-shah-et-al
#17
Neil Garrett, Tali Sharot
A diverse body of research has demonstrated that people update their beliefs to a greater extent when receiving good news compared to bad news. Recently, a paper by Shah et al. claimed that this asymmetry does not exist. Here we carefully examine the experiments and simulations described in Shah et al. and follow their analytic approach on our data sets. After correcting for confounds we identify in the experiments of Shah et al., an optimistic update bias for positive life events is revealed. Contrary to claims made by Shah et al...
November 8, 2016: Consciousness and Cognition
https://www.readbyqxmd.com/read/27830187/germline-and-somatic-mutations-in-the-mtor-gene-in-focal-cortical-dysplasia-and-epilepsy
#18
Rikke S Møller, Sarah Weckhuysen, Mathilde Chipaux, Elise Marsan, Valerie Taly, E Martina Bebin, Susan M Hiatt, Jeremy W Prokop, Kevin M Bowling, Davide Mei, Valerio Conti, Pierre de la Grange, Sarah Ferrand-Sorbets, Georg Dorfmüller, Virginie Lambrecq, Line H G Larsen, Eric Leguern, Renzo Guerrini, Guido Rubboli, Gregory M Cooper, Stéphanie Baulac
OBJECTIVE: To assess the prevalence of somatic MTOR mutations in focal cortical dysplasia (FCD) and of germline MTOR mutations in a broad range of epilepsies. METHODS: We collected 20 blood-brain paired samples from patients with FCD and searched for somatic variants using deep-targeted gene panel sequencing. Germline mutations in MTOR were assessed in a French research cohort of 93 probands with focal epilepsies and in a diagnostic Danish cohort of 245 patients with a broad range of epilepsies...
December 2016: Neurology. Genetics
https://www.readbyqxmd.com/read/27826120/mitochondrial-oxidative-phosphorylation-disorders-in-children-phenotypic-genotypic-and-biochemical-correlations-in-85-patients-from-south-india
#19
Kothari Sonam, Parayil Sankaran Bindu, M M Srinivas Bharath, Periyasamy Govindaraj, Narayanappa Gayathri, Hanumanthapura R Arvinda, Shwetha Chiplunkar, Madhu Nagappa, Sanjib Sinha, Nahid Akhtar Khan, Vandana Nunia, Arumugam Paramasivam, Kumarasamy Thangaraj, Arun B Taly
Mitochondrial oxidative phosphorylation (OXPHOS) disorders accounts for a variety of neuromuscular disorders in children. In this study mitochondrial respiratory chain enzymes were assayed in muscle tissue in a large cohort of children with varied neuromuscular presentations from June 2011 to December 2013. The biochemical enzyme deficiencies were correlated with the phenotypes, magnetic resonance imaging, histopathology and genetic findings to reach a final diagnosis. There were 85 children (mean age: 6.9±4...
November 5, 2016: Mitochondrion
https://www.readbyqxmd.com/read/27815810/ankle-foot-orthosis-in-duchenne-muscular-dystrophy-a-4%C3%A2-year-experience-in-a-multidisciplinary-neuromuscular-disorders-clinic
#20
Anupam Gupta, Atchayaram Nalini, Shanti Prakash Arya, Seena Vengalil, Meeka Khanna, Rashmi Krishnan, Arun B Taly
OBJECTIVE: To assess Ankle-Foot-Orthosis (AFO) requirement and ambulation in Duchenne Muscular Dystrophy (DMD) patients seen over a period of 4 y at a multi-disciplinary Neuromuscular disorders clinic (NMD). METHODS: A study was conducted in university quaternary research hospital with DMD patients confirmed by MLPA (multiplex ligation - dependent probe amplification) method and were evaluated between January 2012 and December 2015. Their ambulatory status, detailed neurological and functional status were recorded...
November 5, 2016: Indian Journal of Pediatrics
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